CN111773151B - Whitening and freckle-removing antioxidant emulsion and preparation method thereof - Google Patents
Whitening and freckle-removing antioxidant emulsion and preparation method thereof Download PDFInfo
- Publication number
- CN111773151B CN111773151B CN202010641611.XA CN202010641611A CN111773151B CN 111773151 B CN111773151 B CN 111773151B CN 202010641611 A CN202010641611 A CN 202010641611A CN 111773151 B CN111773151 B CN 111773151B
- Authority
- CN
- China
- Prior art keywords
- phase
- homogenizing
- parts
- heating
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000839 emulsion Substances 0.000 title claims abstract description 67
- 230000002087 whitening effect Effects 0.000 title claims abstract description 44
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 38
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 36
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000004945 emulsification Methods 0.000 title description 4
- 239000000284 extract Substances 0.000 claims abstract description 28
- 239000003755 preservative agent Substances 0.000 claims abstract description 26
- 230000002335 preservative effect Effects 0.000 claims abstract description 26
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims abstract description 11
- 238000010438 heat treatment Methods 0.000 claims description 114
- 238000002156 mixing Methods 0.000 claims description 86
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 83
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 48
- 239000008367 deionised water Substances 0.000 claims description 47
- 229910021641 deionized water Inorganic materials 0.000 claims description 47
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 34
- 235000006708 antioxidants Nutrition 0.000 claims description 31
- 235000011187 glycerol Nutrition 0.000 claims description 31
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 30
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 18
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 18
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 18
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 18
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 claims description 17
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 17
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 17
- 229940032094 squalane Drugs 0.000 claims description 17
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 16
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 16
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 16
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 16
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 16
- 229930003799 tocopherol Natural products 0.000 claims description 16
- 229960001295 tocopherol Drugs 0.000 claims description 16
- 239000011732 tocopherol Substances 0.000 claims description 16
- 235000010384 tocopherol Nutrition 0.000 claims description 16
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 16
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 15
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 15
- 241000196324 Embryophyta Species 0.000 claims description 15
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 15
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 15
- 229940048053 acrylate Drugs 0.000 claims description 15
- 229960000458 allantoin Drugs 0.000 claims description 15
- 150000001413 amino acids Chemical class 0.000 claims description 15
- 229920006037 cross link polymer Polymers 0.000 claims description 15
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 15
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 15
- 239000003906 humectant Substances 0.000 claims description 15
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims description 15
- 229960000401 tranexamic acid Drugs 0.000 claims description 15
- IHRKJQSLKLYWBQ-QKDODKLFSA-N (2s)-2-[[(2s)-1-[(2s)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical group CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O IHRKJQSLKLYWBQ-QKDODKLFSA-N 0.000 claims description 14
- 229940024606 amino acid Drugs 0.000 claims description 14
- 229920001577 copolymer Polymers 0.000 claims description 14
- 229940047670 sodium acrylate Drugs 0.000 claims description 14
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 claims description 13
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 13
- 241000220317 Rosa Species 0.000 claims description 13
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 13
- 229940094946 palmitoyl tetrapeptide-7 Drugs 0.000 claims description 12
- 150000002148 esters Chemical class 0.000 claims description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical compound CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 2
- 235000010987 pectin Nutrition 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 239000003995 emulsifying agent Substances 0.000 abstract description 7
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 2
- 235000016709 nutrition Nutrition 0.000 abstract description 2
- 230000035764 nutrition Effects 0.000 abstract description 2
- 230000032683 aging Effects 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 26
- 239000000243 solution Substances 0.000 description 14
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- -1 caprylyl hydroxamic Chemical compound 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 7
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 7
- 229940015975 1,2-hexanediol Drugs 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 230000016615 flocculation Effects 0.000 description 4
- 238000005189 flocculation Methods 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 244000068988 Glycine max Species 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 3
- 230000032798 delamination Effects 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 2
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 2
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- 229920002498 Beta-glucan Polymers 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 235000017788 Cydonia oblonga Nutrition 0.000 description 2
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 2
- LOXVSKUQULMRNO-HVDRVSQOSA-N N[C@@H](CCC(N)=O)C(=O)O.C(CCCCCCCCCCC)(=O)N Chemical compound N[C@@H](CCC(N)=O)C(=O)O.C(CCCCCCCCCCC)(=O)N LOXVSKUQULMRNO-HVDRVSQOSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 206010034018 Parosmia Diseases 0.000 description 2
- 235000000539 Rosa canina Nutrition 0.000 description 2
- 240000008530 Rosa canina Species 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- FOLJTMYCYXSPFQ-CJKAUBRRSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-(octadecanoyloxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl octadecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)O[C@@H]1O[C@@]1(COC(=O)CCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@@H](CO)O1 FOLJTMYCYXSPFQ-CJKAUBRRSA-N 0.000 description 2
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 239000004064 cosurfactant Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- VWTINHYPRWEBQY-UHFFFAOYSA-N denatonium Chemical compound [O-]C(=O)C1=CC=CC=C1.C=1C=CC=CC=1C[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C VWTINHYPRWEBQY-UHFFFAOYSA-N 0.000 description 2
- 229960001610 denatonium benzoate Drugs 0.000 description 2
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 2
- 229940100524 ethylhexylglycerin Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 229940100554 isononyl isononanoate Drugs 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- MFYAQFYIDXXKQG-MLCQCVOFSA-N (2s)-2-[[(2s)-4-amino-2-[[(2s)-2-[[(2s)-2-(hexadecanoylamino)-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]propanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(O)=O MFYAQFYIDXXKQG-MLCQCVOFSA-N 0.000 description 1
- BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 1
- KZEVSDGEBAJOTK-UHFFFAOYSA-N 1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-2-[5-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]ethanone Chemical compound N1N=NC=2CN(CCC=21)C(CC=1OC(=NN=1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)=O KZEVSDGEBAJOTK-UHFFFAOYSA-N 0.000 description 1
- LDXJRKWFNNFDSA-UHFFFAOYSA-N 2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound C1CN(CC2=NNN=C21)CC(=O)N3CCN(CC3)C4=CN=C(N=C4)NCC5=CC(=CC=C5)OC(F)(F)F LDXJRKWFNNFDSA-UHFFFAOYSA-N 0.000 description 1
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 235000016425 Arthrospira platensis Nutrition 0.000 description 1
- 240000002900 Arthrospira platensis Species 0.000 description 1
- 241000195649 Chlorella <Chlorellales> Species 0.000 description 1
- 244000236931 Cydonia oblonga Species 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000003935 Hippophae Nutrition 0.000 description 1
- 241000229143 Hippophae Species 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000208467 Macadamia Species 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 108010075308 N-palmitoyl-seryl-seryl-asparaginyl-alanine Proteins 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- OTXYHRWHQCDKOS-UHFFFAOYSA-N [Na].CC(C=CC)=O Chemical group [Na].CC(C=CC)=O OTXYHRWHQCDKOS-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229940114077 acrylic acid Drugs 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940067599 ascorbyl glucoside Drugs 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosanyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 229940049294 glyceryl stearate se Drugs 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical group CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229940093932 potassium hydroxide Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- LWBVAHQZGAKXPU-BOXHHOBZSA-M sodium;(4s)-4-amino-5-octadecoxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOC(=O)[C@@H](N)CCC([O-])=O LWBVAHQZGAKXPU-BOXHHOBZSA-M 0.000 description 1
- 229940082787 spirulina Drugs 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a whitening and freckle-removing antioxidant emulsion and a preparation method thereof, and the raw materials comprise: glycyrrhiza glabra root extract, hydrogenated lecithin, E10Liposome, an emulsifier and a preservative. The emulsion disclosed by the invention has the effects of whitening and moisturizing the skin, is also beneficial to providing skin nutrition, has the effects of resisting wrinkles and aging, is mild in property, high in safety, free of side effects on the skin, and is suitable for long-term use.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a whitening and freckle-removing antioxidant emulsion and a preparation method thereof.
Background
With the increasing interest in beauty and skin health, the demand for cosmetics is rapidly increasing. Relevant data show that the number of 'cosmetic population' in China is as high as 4 billion from 2200 million in 2005 to 1 billion in 2015, and is predicted to be 2025, which indicates that the cosmetic market in China has huge development potential. According to the statistics of the product structure in the global cosmetic industry in 2017, the skin care product accounts for 27%, the technical content of the product is continuously improved, and the mass consumption of the cosmetics is advanced to medium and high. Due to the continuous improvement of living standard and the acceleration of living rhythm of people, people put forward multiple requirements on individuation, convenience, high quality, high efficiency, natural health and the like on skin care products, so the skin care product market is one of the fastest-developing markets in the cosmetic industry.
The lotion contains a certain amount of water to supplement water for skin, and a small amount of oil to moisten skin. Traditional emulsion generally is the grease that uses the chemical synthesis, the grease content is unreasonable, be difficult to by skin absorption, lack the nourishing composition, it is not obvious to whiten the effect, and because the continuous improvement of people's living standard and the acceleration of life rhythm, people propose the multiple requirement of individuation, it is convenient, high-quality high efficiency, natural health etc. to skin care products, many whitening compositions, it has good effects to be confirmed, but the composition is unstable, and the antiseptic that adds has irritability to the skin, more and more women need safety, it is convenient to use, simplify the skin care product of skin care flow, consequently need one kind simultaneously have whiten, remove the macula, anti-aging, the skin care products of multiple efficiency such as nonirritant in order to solve above-mentioned problem urgently.
Disclosure of Invention
The invention aims to provide a whitening and freckle-removing antioxidant emulsion and a preparation method thereof, which are used for solving one or more technical problems in the prior art and at least providing a beneficial choice or creating conditions.
In order to realize the purpose, the technical scheme is as follows:
a whitening and freckle-removing antioxidant emulsion comprises the following raw materials: glycyrrhiza glabra root extract, hydrogenated lecithin, E10Liposome, an emulsifier and a preservative.
The emulsifiers are MONTANOV82 (cetearyl alcohol (and) cocoyl glucoside) and cetostearyl alcohol.
The preservative is a composition of at least two of caprylyl hydroximic acid, 1, 2-hexanediol, caprylyl glycol and ethylhexyl glycerin.
The raw materials of the whitening and freckle-removing antioxidant emulsion comprise, by weight, 0.01-3 parts of glycyrrhiza glabra root extract, 0.1-1 part of hydrogenated lecithin, 0.2-1.6 parts of an emulsifier and 0.1-2.5 parts of a preservative.
The whitening and freckle-removing antioxidant emulsion also comprises the following raw materials: glycerin, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid, an amino acid humectant, dioctyl carbonate, plant squalane, tocopherol, acrylic acid/C10-30 alkanol acrylate crosspolymer, L-ascorbic acid 2-glucoside, potassium hydroxide, palmitoyl tetrapeptide-7, sodium hyaluronate, rose hydrosol, tris (hydroxymethyl) aminomethane, and a sodium acrylate/sodium acryloyldimethyl taurate copolymer.
Wherein the sodium hyaluronate is 1% sodium hyaluronate solution.
The whitening and freckle-removing antioxidant emulsion comprises the following raw materials in parts by weight: 0.01-3 parts of glycyrrhiza glabra root extract, 1.1-35 parts of glycerol, 0.1-1 part of hydrogenated lecithin, 0.01-0.04 part of ethylene diamine tetraacetic acid disodium, 0.01-0.1 part of dipotassium glycyrrhizinate, 0.1-0.5 part of allantoin, 1-5 parts of nicotinamide, 1-3 parts of tranexamate, 0.5-2 parts of amino acid humectant, 0.1-0.6 part of MONTANOV82, 0.1-1 part of cetostearyl alcohol, 1-6 parts of dioctyl carbonate, 0.5-2 parts of plant squalane, 0.1-0.5 part of tocopherol, 0.1-0.3 part of acrylic acid (ester) class/C10-30 alkanol acrylate cross-linked polymer, 0.1-1 part of L-ascorbic acid 2-glucoside, 0.01-0.05 part of potassium hydroxide, 0.1-1 part of palmitoyl tetrapeptide-7 parts of sodium hyaluronate solution, 0.1-2.5 parts of E10-lipome preservative, 0.1-1.5 parts of Lipomme, 0.1-1 part of sodium hydroxide, 0.5-1 part of pure acrylamide and 0.5-1 part of sodium methylacryloylmethane/1-1 part of sodium polyacrylate.
The preparation method of the whitening and freckle-removing antioxidant emulsion is characterized by comprising the following specific steps:
(1) Mixing Glycyrrhrizae radix extract with part of glycerol to obtain phase A;
(2) Mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) Heating deionized water, disodium edetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and amino acid humectant for dissolving, and homogenizing to obtain phase C;
(4) Adding phase B into phase C, mixing and heating, then adding phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1;
(5) Mixing MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, heating for dissolving, and homogenizing to obtain phase D;
(6) Heating, mixing and dissolving the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain an E phase;
(7) Heating, mixing and dissolving L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, and homogenizing to obtain an F phase;
(8) Adding the mixed phase 1 into the phase D, mixing, heating and dissolving, adding the phase E and the phase F in sequence after homogenizing, then mixing, heating and homogenizing to obtain a mixed phase 2;
(9) Mixing, heating and dissolving palmitoyl tetrapeptide-7, a sodium hyaluronate solution, E10Liposome, a preservative and rose hydrosol, and then homogenizing to obtain a G phase;
(10) Mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain an H phase;
(11) And respectively adding the phase G and the phase H into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion.
In the step (1), the ratio of the glycyrrhiza glabra rhizome extract to the glycerol is 1:10.
the weight part of the deionized water added in the step (3) is 88-100 parts.
And (3) adding 1-3 parts of deionized water in the step (6).
The weight part of deionized water added in the step (7) is 1-3 parts.
The weight part of the deionized water added in the step (10) is 1-3 parts.
The heating and dissolving temperature in the step (3) is 60-75 ℃, the homogenizing speed is 2000-2500r/min, and the homogenizing time is 3-5min.
The heating and dissolving temperature in the step (4) is 60-75 ℃, the homogenizing speed is 2000-2500r/min, and the homogenizing time is 3-5min.
The heating and dissolving temperature in the step (5) is 60-75 ℃, the homogenizing speed is 4500-5200r/min, and the homogenizing time is 3-5min.
The heating and dissolving temperature in the step (6) is 60-75 ℃, the homogenizing speed is 4500-5200r/min, and the homogenizing time is 1-3min.
The heating and dissolving temperature in the step (7) is 50 ℃, the homogenizing speed is 4500-5200r/min, and the homogenizing time is 1min.
In the step (8), the temperature of the first mixing and heating is 70 ℃, the speed of the first homogenizing is 4500-5200r/min, the temperature of the second mixing and heating is 50 ℃, the speed of the second homogenizing is 4800-5000r/min, and the homogenizing time is 1min.
The heating and dissolving temperature in the step (9) is 50 ℃, the homogenizing speed is 4500-5200r/min, and the homogenizing time is 1min.
The heating and dissolving temperature in the step (10) is 50 ℃, the homogenizing speed is 4500-5200r/min, and the homogenizing time is 1-2min.
The heating and dissolving temperature in the step (11) is 50 ℃, the homogenizing speed is 4500-5200r/min, and the homogenizing time is 1-2min.
The E10Liposome in the raw materials of the whitening and freckle-removing antioxidant emulsion can assist penetration of functional components on hydrogenated lecithin, reduce the problem that the functional components are difficult to absorb, and simultaneously has strong antioxidant effect, and the glycyrrhiza glabra rhizome extract has the whitening effect.
According to the invention, MONTANOV82 and cetostearyl alcohol are used as emulsifiers, a micro-emulsification system of a thermodynamically stable oil-water-surfactant-cosurfactant homogeneous system can be formed in the emulsion, and the stability of the emulsion is improved.
The emulsion disclosed by the invention is prepared by compounding the glycyrrhiza glabra rhizome extract, E10Liposome, hydrogenated lecithin, tranexamic acid, nicotinamide and L-ascorbic acid 2-glucoside, so that the skin whitening and moisturizing effect is achieved, meanwhile, the skin nutrition is favorably provided, the anti-aging and freckle removing effects are achieved, the emulsion is mild in property, high in safety, free of side effects and stimulation on skin, and is suitable for long-term use.
French seebeck emulsifiers of the invention: MONTANOV82, purchased from Kango corporation of July, guangzhou.
The E10Liposome is purchased from Guangzhou Curie chemical science and technology Limited, the E10Liposome is a lecithin-wrapped product of 11 plant extracts, and the 11 plant extracts are respectively as follows: bonnet spirulina, chlorella, rice germ, fructus Hordei vulgaris, fructus Hordei Germinatus, wild soybean sprout, semen Sesami sprout, fructus Hippophae, fructus Lycopersici Esculenti, fructus Punicae Granati, and folium Vaccinii Vitis-idaeae extract.
The invention has the beneficial effects that: the skin care lotion has multiple effects, simplifies the skin care process, adopts the emulsion state as a reference in the formula design, can achieve the multifunctional effects of toner, essence, emulsion, sleep mask and the like by taking the comfortable skin feeling and efficacy, selects a novel formula technology to ensure that the components can better permeate into the skin to play a role, selects the alcohol preservative to replace the conventional preservative to ensure the mildness of the product, selects the raw materials with relatively high stability, solves the problem of stability by compounding with other components, and greatly reduces the irritation to the skin.
Detailed Description
The following steps are only used for illustrating the technical scheme of the invention and are not limited; although the present invention has been described in detail with reference to the foregoing steps, it will be understood by those of ordinary skill in the art that: the technical solutions recorded in the foregoing steps may still be modified, or some or all of the technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the present invention in its steps.
Example 1
The whitening and freckle-removing antioxidant emulsion comprises the following raw materials in percentage by weight: 0.01 part of glycyrrhiza glabra root extract, 1.1 part of glycerol, 0.1 part of hydrogenated lecithin, 0.01 part of disodium ethylene diamine tetraacetate, 0.01 part of dipotassium glycyrrhizinate, 0.1 part of allantoin, 1 part of nicotinamide, 1 part of tranexamic acid, 0.5 part of amino acid humectant, 0.1 part of MONTANOV82, 0.1 part of cetostearyl alcohol, 1 part of dioctyl carbonate, 0.5 part of plant squalane, 0.1 part of tocopherol, 0.1 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.1 part of L-ascorbic acid 2-glucoside, 0.01 part of potassium hydroxide, 0.1 part of palmitoyl tetrapeptide-7, 0.1 part of 1% sodium hyaluronate solution, 0.1 part of E10Liposome, 0.1 part of preservative, 1 part of rose hydrosol, 0.05 part of tris (hydroxymethyl) aminomethane and 0.1 part of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a combination of caprylyl glycol and ethylhexyl glycerin.
According to the raw materials and the addition amount, the preparation method of the whitening and freckle-removing antioxidant emulsion comprises the following specific steps:
(1) Mixing the glycyrrhiza glabra rhizome extract with partial glycerin to obtain phase A, wherein the ratio of glycyrrhiza glabra rhizome extract to glycerin is 1:10;
(2) Mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) Heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and an amino acid humectant, and homogenizing to obtain a phase C, wherein the added weight part of the deionized water is 88 parts, the heating and dissolving temperature is 60 ℃, the homogenizing speed is 2000r/min, and the homogenizing time is 5min;
(4) Adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1, wherein the heating and dissolving temperature is 60 ℃, the homogenizing speed is 2000r/min, and the homogenizing time is 5min;
(5) Mixing, heating and dissolving MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, and homogenizing to obtain phase D, wherein the heating and dissolving temperature is 60 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 5min;
(6) Heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E, wherein the added weight part of the deionized water is 1 part, the heating and dissolving temperature is 60 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 3min;
(7) Mixing L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, heating for dissolving, and homogenizing to obtain phase F, wherein the deionized water is added in 1 part by weight, the heating and dissolving temperature is 50 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 1min;
(8) Adding the mixed phase 1 into the phase D, mixing and heating at 70 ℃ for dissolving, homogenizing at 4500r/min, then sequentially adding the phase E and the phase F, mixing and heating at 50 ℃, and homogenizing at 4800r/min for 1min to obtain a mixed phase 2;
(9) Mixing, heating and dissolving palmitoyl tetrapeptide-7, a sodium hyaluronate solution, E10Liposome, a preservative and rose hydrosol, and homogenizing to obtain a G phase, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 1min;
(10) Mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain H phase, wherein the weight part of deionized water is 1 part, the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 2min;
(11) And sequentially adding the G phase and the H phase into the mixed phase 2, mixing, heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing, heating and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 2min.
Example 2
The skin whitening, freckle removing and antioxidant emulsion comprises the following raw materials in percentage by weight: 3 parts of glycyrrhiza glabra root extract, 35 parts of glycerol, 1 part of hydrogenated lecithin, 0.04 part of disodium ethylene diamine tetraacetate, 0.1 part of dipotassium glycyrrhizinate, 0.5 part of allantoin, 5 parts of nicotinamide, 3 parts of tranexamic acid, 2 parts of amino acid humectant, 0.6 part of MONTANOV82, 1 part of cetostearyl alcohol, 6 parts of dioctyl carbonate, 2 parts of plant squalane, 0.5 part of tocopherol, 0.3 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 1 part of L-ascorbic acid 2-glucoside, 0.05 part of potassium hydroxide, 71 parts of palmitoyl tetrapeptide, 2.5 parts of 1% sodium hyaluronate solution, 1 part of E10Liposome, 2.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylyl hydroxamic acid, 1, 2-hexanediol, caprylyl glycol and ethylhexyl glycerol.
According to the raw materials and the addition amount, the preparation method of the whitening and freckle-removing antioxidant emulsion comprises the following specific steps:
(1) Mixing the Glycyrrhiza glabra rhizome extract with partial glycerin to obtain phase A, wherein the ratio of the Glycyrrhiza glabra rhizome extract to the glycerin is 1:10;
(2) Mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) Heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and amino acid humectant, and homogenizing to obtain phase C, wherein the weight part of deionized water is 100 parts, the heating and dissolving temperature is 75 ℃, the homogenizing speed is 2500r/min, and the homogenizing time is 3min;
(4) Adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1, wherein the heating and dissolving temperature is 75 ℃, the homogenizing speed is 2000r/min, and the homogenizing time is 5min;
(5) Mixing, heating and dissolving MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, and homogenizing to obtain phase D, wherein the heating and dissolving temperature is 75 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 3min;
(6) Heating, mixing and dissolving the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E, wherein the deionized water is added in 3 parts by weight, the heating and dissolving temperature is 75 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1min;
(7) Mixing, heating and dissolving L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, and homogenizing to obtain phase F, wherein the weight part of deionized water is 3, the heating and dissolving temperature is 50 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1min;
(8) Adding the mixed phase 1 into the phase D, mixing and heating at 70 ℃ for dissolution, homogenizing at 5200r/min, sequentially adding the phase E and the phase F, mixing and heating at 50 ℃, and homogenizing at 5000r/min for 1min to obtain a mixed phase 2;
(9) Mixing, heating and dissolving palmitoyl tetrapeptide-7, 1% sodium hyaluronate solution, E10Liposome, preservative and rose hydrosol, and homogenizing to obtain a G phase, wherein the temperature for mixing, heating and dissolving is 50 ℃, the speed for homogenizing is 5200r/min, and the time for homogenizing is 1min;
(10) Mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain H phase, wherein the weight part of deionized water is 1 part, the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1min;
(11) Sequentially adding the G phase and the H phase into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1min.
Example 3
The whitening and freckle-removing antioxidant emulsion comprises the following raw materials in percentage by weight: 2 parts of glycyrrhiza glabra root extract, 25 parts of glycerol, 0.5 part of hydrogenated lecithin, 0.03 part of disodium ethylene diamine tetraacetate, 0.06 part of dipotassium glycyrrhizinate, 0.3 part of allantoin, 3 parts of nicotinamide, 2 parts of tranexamic acid, 1.5 parts of amino acid humectant, 0.4 part of MONTANOV82, 0.5 part of cetostearyl alcohol, 4 parts of dioctyl carbonate, 1.5 parts of plant squalane, 0.3 part of tocopherol, 0.2 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.6 part of L-ascorbic acid 2-glucoside, 0.03 part of potassium hydroxide, 0.6 part of palmitoyl tetrapeptide-7, 1.8 parts of 1% sodium hyaluronate solution, 0.5 part of E10Liposome, 1.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylyl hydroxamic acid and 1, 2-hexanediol.
According to the raw materials and the addition amount, the preparation method of the whitening and freckle-removing antioxidant emulsion comprises the following specific steps:
(1) Mixing the Glycyrrhiza glabra rhizome extract with partial glycerin to obtain phase A, wherein the ratio of the Glycyrrhiza glabra rhizome extract to the glycerin is 1:10;
(2) Mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) Heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and an amino acid humectant, and homogenizing to obtain a phase C, wherein the adding weight part of the deionized water is 95 parts, the heating and dissolving temperature is 70 ℃, the homogenizing speed is 2300r/min, and the homogenizing time is 4min;
(4) Adding phase B into phase C, mixing and heating, then adding phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1, wherein the heating and dissolving temperature is 70 ℃, the homogenizing speed is 2300r/min, and the homogenizing time is 4min;
(5) Mixing MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, heating for dissolving, and homogenizing to obtain phase D, wherein the heating and dissolving temperature is 70 deg.C, the homogenizing speed is 5000r/min, and the homogenizing time is 4min;
(6) Heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E, wherein the added weight part of the deionized water is 2 parts, the heating and dissolving temperature is 70 ℃, the homogenizing speed is 4900r/min, and the homogenizing time is 2min;
(7) Mixing, heating and dissolving L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, and homogenizing to obtain phase F, wherein the weight part of deionized water is 2, the heating and dissolving temperature is 50 ℃, the homogenizing speed is 5100r/min, and the homogenizing time is 1min;
(8) Adding the mixed phase 1 into the phase D, mixing and heating at 70 ℃ for dissolving, homogenizing at 4800r/min, sequentially adding the phase E and the phase F, mixing and heating at 50 ℃, and homogenizing at 4900r/min for 1min to obtain a mixed phase 2;
(9) Mixing, heating and dissolving palmitoyl tetrapeptide-7, a 1% sodium hyaluronate solution, E10Liposome, a preservative and rose hydrosol, and then homogenizing to obtain a G phase, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4700r/min, and the homogenizing time is 1min;
(10) Mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain H phase, wherein the added weight part of deionized water is 2 parts, the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5000r/min, and the homogenizing time is 2min;
(11) And sequentially adding the G phase and the H phase into the mixed phase 2, mixing, heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing, heating and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4800r/min, and the homogenizing time is 2min.
Further effect tests were conducted on the above examples 1 to 3.
1. Stability detection
The emulsion is a thermodynamically unstable system, and an over-acceleration test, a real-time test and a rheological measurement are carried out to ensure that the product is stable and safe within the shelf life.
Comparative example 1: an emulsion, comprising: 2 parts of glycyrrhiza glabra root extract, 25 parts of glycerol, 0.5 part of hydrogenated lecithin, 0.03 part of disodium ethylenediamine tetraacetate, 0.06 part of dipotassium glycyrrhizinate, 0.3 part of allantoin, 3 parts of nicotinamide, 2 parts of tranexamic acid, 1.5 parts of an amino acid humectant, 4 parts of dioctyl carbonate, 1.5 parts of plant squalane, 0.3 part of tocopherol, 0.2 part of acrylic acid/C10-30 alkanol acrylate cross-linked polymer, 0.6 part of L-ascorbic acid 2-glucoside, 0.03 part of potassium hydroxide, 0.6 part of palmitoyl tetrapeptide-7, 1.8 parts of 1% sodium hyaluronate solution, 0.5 part of E10 lipome, 1.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylhydroxamic acid and 1, 2-hexanediol.
Comparative example 2: an emulsion, comprising: 2 parts of glycyrrhiza glabra root extract, 25 parts of glycerol, 0.5 part of hydrogenated lecithin, 0.03 part of disodium ethylene diamine tetraacetate, 0.06 part of dipotassium glycyrrhizinate, 0.3 part of allantoin, 3 parts of nicotinamide, 2 parts of tranexamic acid, 1.5 parts of amino acid humectant, 0.5 part of cetostearyl alcohol, 4 parts of dioctyl carbonate, 1.5 parts of plant squalane, 0.3 part of tocopherol, 0.2 part of acrylic acid/C10-30 alkanol acrylate cross-linked polymer, 0.6 part of L-ascorbic acid 2-glucoside, 0.03 part of potassium hydroxide, 0.6 part of palmitoyl tetrapeptide-7, 1.8 parts of 1% sodium hyaluronate solution, 0.5 part of E10Liposome, 1.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylyl hydroxamic acid and 1, 2-hexanediol
Comparative example 3: an emulsion, comprising: 2 parts of glycyrrhiza glabra root extract, 25 parts of glycerol, 0.5 part of hydrogenated lecithin, 0.03 part of ethylene diamine tetraacetic acid, 0.06 part of dipotassium glycyrrhizinate, 0.3 part of allantoin, 3 parts of nicotinamide, 2 parts of tranexamic acid, 1.5 parts of amino acid humectant, 0.4 part of MONTANOV82, 4 parts of dioctyl carbonate, 1.5 parts of plant squalane, 0.3 part of tocopherol, 0.2 part of acrylic acid/C10-30 alkanol acrylate cross-linked polymer, 0.6 part of L-ascorbic acid 2-glucoside, 0.03 part of potassium hydroxide, 0.6 part of palmitoyl tetrapeptide-7, 1.8 parts of 1% sodium hyaluronate solution, 0.5 part of E10 lipome, 1.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylyl hydroxamic acid and 1, 2-hexanediol.
The preparation method of the emulsion described in the above comparative examples 1 to 3 specifically comprises the steps of:
(1) Mixing the Glycyrrhiza glabra rhizome extract with partial glycerin to obtain phase A, wherein the ratio of the Glycyrrhiza glabra rhizome extract to the glycerin is 1:10;
(2) Mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) Heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and an amino acid humectant, and homogenizing to obtain a phase C, wherein the added weight part of the deionized water is 95 parts, the heating and dissolving temperature is 70 ℃, the homogenizing speed is 2300r/min, and the homogenizing time is 4min;
(4) Adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1, wherein the heating and dissolving temperature is 70 ℃, the homogenizing speed is 2300r/min, and the homogenizing time is 4min;
(5) Mixing, heating and dissolving dioctyl carbonate, plant squalane and tocopherol (hexadecanol with the corresponding addition amount is added in the preparation of comparative example 2, MONTANOV82 with the corresponding addition amount is added in the preparation of comparative example 3), and homogenizing to obtain phase D, wherein the heating and dissolving temperature is 70 ℃, the homogenizing speed is 5000r/min, and the homogenizing time is 4min;
(6) Heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E, wherein the added weight part of the deionized water is 2 parts, the heating and dissolving temperature is 70 ℃, the homogenizing speed is 4900r/min, and the homogenizing time is 2min;
(7) Mixing, heating and dissolving L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, and homogenizing to obtain phase F, wherein the weight part of deionized water is 2, the heating and dissolving temperature is 50 ℃, the homogenizing speed is 5100r/min, and the homogenizing time is 1min;
(8) Adding the mixed phase 1 into the phase D, mixing and heating at 70 ℃ for dissolving, homogenizing at 4800r/min, sequentially adding the phase E and the phase F, mixing and heating at 50 ℃, and homogenizing at 4900r/min for 1min to obtain a mixed phase 2;
(9) Mixing, heating and dissolving palmitoyl tetrapeptide-7, a 1% sodium hyaluronate solution, E10Liposome, a preservative and rose hydrosol, and then homogenizing to obtain a G phase, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4700r/min, and the homogenizing time is 1min;
(10) Mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain H phase, wherein the added weight part of deionized water is 2 parts, the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5000r/min, and the homogenizing time is 2min;
(11) And sequentially adding the phase G and the phase H into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4800r/min, and the homogenizing time is 2min.
Comparative example 4: an emulsion, comprising: 7 parts of 1, 3-butanediol, 5 parts of betaine, 3 parts of 1, 2-pentanediol, 3 parts of squalane, 3 parts of polydimethylsiloxane, 2.5 parts of cetostearyl alcohol, 2 parts of glycerol, 1 part of sucrose stearate, 1 part of sucrose distearate, 0.6 part of isononyl isononanoate, 0.05 part of sodium bis (lauramide glutamine) lysine, 0.5 part of bis-diglycerol polyacyladipate, 0.3 part of PEG-45 stearate, 0.0015 part of beta-glucan, 0.2 part of arginine, 0.2 part of polyacrylic acid, 0.0025 part of hydrolyzed vegetable protein, 0.0025 part of adenosine triphosphate, 0.0025 part of sodium chondroitin sulfate, 0.4 part of MONNOV 820.4 part of hexadecadecanol, 0.01 part of sodium citrate, 0.003 part of citric acid, 0.00002 part of denatonium benzoate and 1 part of macadamia nut oil.
Comparative example 5: an emulsion, comprising: 7 parts of 1, 3-butanediol, 5 parts of betaine, 3 parts of 1, 2-pentanediol, 3 parts of squalane, 3 parts of polydimethylsiloxane, 2.5 parts of cetostearyl alcohol, 2 parts of glycerol, 1 part of sucrose stearate, 1 part of sucrose distearate, 0.6 part of isononyl isononanoate, 0.05 part of sodium bis (lauramide glutamine) lysine, 0.5 part of bis-diglycerol polyacyladipate, 0.3 part of PEG-45 stearate, 0.0015 part of beta-glucan, 0.2 part of arginine, 0.2 part of polyacrylic acid, 0.0025 part of hydrolyzed vegetable protein, 0.0025 part of adenosine triphosphate, 0.0025 part of sodium chondroitin sulfate, 0.01 part of sodium citrate, 0.003 part of citric acid, 0.00002 part of denatonium benzoate and 1 part of macadamia seed oil.
Accelerated testing: experimental groups: respectively storing the emulsions of the examples 1-3 and the comparative examples 1-5 at 50 ℃ for 24h and at room temperature for 24h; control group: the emulsions prepared in examples 1 to 3 and comparative example 1 were stored at room temperature for 48 hours, and changes in aggregation and flocculation, appearance and viscosity were observed by light reflection.
And (3) real-time experiment: the emulsions described in examples 1 to 3 and comparative examples 1 to 5 above were observed for changes in appearance, odor, and the like at different times without applying a load to the emulsions and stored for a long period of time depending on the initial characteristics.
And (3) centrifugal experiment: the emulsions of examples 1 to 3 and comparative examples 1 to 5 were placed in a centrifuge, respectively, and tested at a rotation speed of 4000r/min for 30min to observe the separation and delamination of the emulsions of examples 1 to 3 and comparative examples 1 to 5.
The results are shown in table 1, the whitening, freckle removing and antioxidant emulsions prepared in examples 1,2 and 3 have no abnormality and no obvious change when compared with a control group through an accelerated test, while the emulsions described in comparative example 1 have reduced viscosity and flocculation, the emulsions described in comparative example 2 have reduced viscosity but no flocculation, and the emulsions described in comparative examples 3 and 4 have no abnormality and the emulsions described in comparative example 5 have reduced viscosity and flocculation; the whitening and freckle-removing antioxidant emulsions prepared in the examples 1,2 and 3 have no abnormal appearance, smell and layering phenomenon after the implementation test and the centrifugal test, while the emulsion in the comparative example 1 has changed smell after two months and has layering phenomenon after the centrifugal test; in comparative example 2, the smell changes after 4 months, and in comparative example 3, the smell changes after five months, and the layering phenomenon occurs; comparative example 4 smell changed over three months, delamination occurred; comparative example 5 changed odor over a period of one month and delamination occurred. Therefore, MONTANOV82 and hexadecanol are used as emulsifying agents, a micro-emulsification system of a thermodynamically stable oil-water-surfactant-cosurfactant homogeneous system can be formed in the emulsion, and the stability of the emulsion is improved, so that the whitening and freckle-removing antioxidant emulsion has good stability.
TABLE 1 stability test results
2. Sensory evaluation
60 persons were selected and divided into 3 groups on average, and the whitening and spot-removing antioxidant emulsions prepared in example 1, example 2 and example 3 were subjected to sensory evaluation from sampling, painting and after-use feeling, respectively.
Sampling: the sensory properties evaluated were consistency, perceived ease of removal, which can be divided into three grades: low consistency, medium consistency and high consistency.
Smearing: the effect was evaluated by gently moving the skin in a circular motion at a rate of two revolutions per second, followed by rubbing the skin for a further period of time. Mainly including dispersibility and absorbency.
Feeling after use: after the product was applied to the skin, the type of residue on the skin and a description of the skin feel of the product were judged.
The results are shown in table 2, and it can be seen that the whitening and freckle-removing antioxidant emulsion of the invention is mild and non-irritating after being used, is relatively refreshing and light and thin when being used, and is fast to absorb and non-sticky.
TABLE 2 sensory evaluation
3. Efficacy test
Comparative example 6: the commercially available whitening and freckle-removing emulsion containing glycyrrhiza glabra rhizomes comprises the following raw materials: water, butylene glycol, glycerol tri (ethylhexanoate), glycerol, neopentyl glycol dicaprate, ascorbyl glucoside, glyceryl stearate SE, sodium hyaluronate, phenoxyethanol, methylparaben, polyglyceryl-10 myristate, cetostearyl alcohol, cetostearyl glucoside, quince (PYRUS CYDONIA) seed extract, sodium citrate, behenyl alcohol hydrogenated lecithin, sorbitan polyether-60 tetraoleate, xanthan gum, potassium hydroxide, polydimethylsiloxane, serine, sodium stearyl glutamate, propylparaben, trehalose, disodium EDTA, stearyl glycyrrhetate, tocopheryl acetate, GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root extract, tocopherol (vitamin E) soyabean (GLYCINE SOJA) oil, citric acid, rosa canina (rosa canina) fruit oil.
The performance of the whitening and freckle-removing antioxidant emulsion described in the embodiment 1, the embodiment 2 and the embodiment 3 and the performance of the comparative example 6 are respectively measured, and 80 testers with darker skin colors are selected, wherein the testers comprise half of each of a man and a woman. Groups were randomized into 4 groups of 10 males and 10 females. 4 groups of 4 used were the emulsion described in example 1, the emulsion described in example 2, the emulsion described in example 3 and the emulsion described in comparative example 6, respectively. The application method is that the skin whitening and freckle removing cream is used after face cleaning every day, once a day, the experimental period is 30 days, and a trial evaluation table is filled according to the whitening and freckle removing antioxidant effects of the cream (wherein an experimenter adopts a grading system, the highest score is 10, the representation effect is obvious, 5 represents that the effect is general, and the lowest score is 1, the representation effect is not effective). The administration was counted once on each of day 5, 10, 15, 20, 25 and 30.
The evaluation results are shown in table 3, and it can be seen that the whitening and freckle-removing antioxidant emulsion has a remarkable whitening and freckle-removing antioxidant effect, and has a more remarkable effect than the commercially available whitening and freckle-removing emulsion containing glycyrrhiza glabra rhizomes. The whitening and freckle-removing antioxidant emulsion disclosed by the invention is comfortable in skin feel in use, free of irritation, remarkable in whitening effect, and healthy and clear in skin after whitening.
TABLE 3 evaluation statistics
| Day 5 | Day 10 | Day 15 | Day 20 | Day 25 | Day 30 | |
| Example 1 | 2 | 3 | 5 | 6 | 7 | 7 |
| Example 2 | 2 | 4 | 6 | 7 | 8 | 8 |
| Example 3 | 2 | 4 | 6 | 8 | 8 | 9 |
| Comparative example 6 | 2 | 4 | 5 | 7 | 7 | 7 |
Claims (4)
1. The whitening and freckle-removing antioxidant emulsion is characterized by comprising the following raw materials in parts by weight: 0.01-3 parts of glycyrrhiza glabra root extract, 1.1-35 parts of glycerol, 0.1-1 part of hydrogenated lecithin, 0.01-0.04 part of disodium ethylene diamine tetraacetate, 0.01-0.1 part of dipotassium glycyrrhizinate, 0.1-0.5 part of allantoin, 1-5 parts of nicotinamide, 1-3 parts of tranexamic acid, 0.5-2 parts of amino acid humectant, 0.1-0.6 part of MONTANOV82, 0.1-1 part of cetostearyl alcohol, 1-6 parts of dioctyl carbonate, 0.5-2 parts of plant squalane, 0.1-0.5 part of tocopherol, 0.1-0.3 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.1-1 part of L-ascorbic acid 2-glucoside, 0.01-0.05 part of potassium hydroxide, 0.1-1 part of palmitoyl tetrapeptide-7 parts, 0.1-2.5 parts of sodium hyaluronate, 0.1-2.5 parts of E10-1 part of pectin, 0.1-1 part of sodium hydroxide, 0.05 part of preservative, 0.1-1 part of pure acrylic acid/1 part of sodium acrylate copolymer, 0.5-1-1.5 parts of deionized water and 0.5 parts of deionized water.
2. The preparation method of the whitening and freckle-removing antioxidant emulsion according to claim 1, which is characterized by comprising the following specific steps:
(1) Mixing Glycyrrhrizae radix extract with part of glycerol to obtain phase A;
(2) Mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) Heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and amino acid humectant, and homogenizing to obtain phase C;
(4) Adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1;
(5) Mixing MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, heating for dissolving, and homogenizing to obtain phase D;
(6) Heating, mixing and dissolving the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain an E phase;
(7) Heating, mixing and dissolving L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, and homogenizing to obtain an F phase;
(8) Adding the mixed phase 1 into the phase D, mixing, heating and dissolving, adding the phase E and the phase F in sequence after homogenizing, then mixing, heating and homogenizing to obtain a mixed phase 2;
(9) Mixing, heating and dissolving palmitoyl tetrapeptide-7, sodium hyaluronate, E10Liposome, preservative and rose hydrosol, and homogenizing to obtain a G phase;
(10) Mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain an H phase;
(11) And respectively adding the phase G and the phase H into the mixed phase 2, mixing, heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing, heating and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion.
3. The method according to claim 2, wherein the ratio of the glycyrrhiza glabra rhizome extract to the glycerin added in the step (1) is 1:10.
4. the method according to claim 2, wherein the deionized water is added in the step (3) in an amount of 88 to 100 parts by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010641611.XA CN111773151B (en) | 2020-07-06 | 2020-07-06 | Whitening and freckle-removing antioxidant emulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010641611.XA CN111773151B (en) | 2020-07-06 | 2020-07-06 | Whitening and freckle-removing antioxidant emulsion and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111773151A CN111773151A (en) | 2020-10-16 |
| CN111773151B true CN111773151B (en) | 2023-01-10 |
Family
ID=72759209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010641611.XA Active CN111773151B (en) | 2020-07-06 | 2020-07-06 | Whitening and freckle-removing antioxidant emulsion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111773151B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315843A (en) * | 2020-12-03 | 2021-02-05 | 广东嘉丹婷日用品有限公司 | Whitening and freckle removing essence and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596273A (en) * | 2015-11-24 | 2016-05-25 | 广州市花安堂生物科技有限公司 | Soothing, moistening, brightening and whitening emulsion and preparation method thereof |
| CN109893464A (en) * | 2019-02-23 | 2019-06-18 | 中美杜克(广州)护肤研究中心(普通合伙) | It is a kind of to block the whitening spot-removing skin care item and preparation method thereof for inhibiting reduction melanin |
| CN109984957A (en) * | 2019-04-17 | 2019-07-09 | 李熙平 | A kind of facial masks for whitening faces and removing spots liquid and preparation method thereof |
| CN111249209A (en) * | 2020-03-30 | 2020-06-09 | 广东芭薇生物科技股份有限公司 | Moisturizing repair cream and preparation method thereof |
-
2020
- 2020-07-06 CN CN202010641611.XA patent/CN111773151B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596273A (en) * | 2015-11-24 | 2016-05-25 | 广州市花安堂生物科技有限公司 | Soothing, moistening, brightening and whitening emulsion and preparation method thereof |
| CN109893464A (en) * | 2019-02-23 | 2019-06-18 | 中美杜克(广州)护肤研究中心(普通合伙) | It is a kind of to block the whitening spot-removing skin care item and preparation method thereof for inhibiting reduction melanin |
| CN109984957A (en) * | 2019-04-17 | 2019-07-09 | 李熙平 | A kind of facial masks for whitening faces and removing spots liquid and preparation method thereof |
| CN111249209A (en) * | 2020-03-30 | 2020-06-09 | 广东芭薇生物科技股份有限公司 | Moisturizing repair cream and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| "素晴茜臻萃卓颜晚安面膜";佚名;《http://cosdna.com/chs/cosmetic_f0e3150029.html》;20140707;第1-3页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111773151A (en) | 2020-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2018196482A1 (en) | Skin care cosmetic composition | |
| CN108969444B (en) | Black eye removing, anti-wrinkle firming and repairing eye cream and preparation method thereof | |
| CN108969446B (en) | Infant anti-chap skin care composition for enhancing skin barrier function and preparation method thereof | |
| CN109453087B (en) | Whitening skin-penetrating lotion, preparation method thereof and whitening cosmetic additive | |
| CN110638709A (en) | Anti-blue-light multi-effect repair eye cream and preparation method thereof | |
| CN110731974B (en) | Skin external composition with enhanced anti-inflammatory efficacy | |
| CN113197836A (en) | Moisturizing, relieving, itching-relieving and skin-protecting cream and preparation method thereof | |
| CN112120986A (en) | Eye repair composition and eye cream containing same | |
| CN109431908B (en) | Whitening and moisturizing cream, preparation method thereof and whitening cosmetic additive | |
| CN109453059B (en) | Whitening cosmetic additive, whitening sleep mask and preparation method of whitening cosmetic additive | |
| CN111686068A (en) | Anti-wrinkle skin-activating cream and preparation method thereof | |
| CN113244144B (en) | Face cream for brightening skin color | |
| CN115364000B (en) | Cosmetic composition with soothing and repairing effects, freeze-dried mask and preparation method | |
| CN110946784A (en) | Skin care composition with functions of improving skin barrier function and enhancing skin health | |
| CN109363991A (en) | A kind of skin care compositions of the plant extracts containing antiallergy | |
| CN115252516A (en) | Water-feeling blush and preparation method thereof | |
| CN111184653A (en) | Vegetable oil skin care composition and preparation method thereof | |
| CN111773151B (en) | Whitening and freckle-removing antioxidant emulsion and preparation method thereof | |
| CN112294739A (en) | Multi-effect whitening composition and application thereof in moisturizer | |
| CN115778870B (en) | Anti-wrinkle anti-aging composition, and preparation method and application thereof | |
| CN114288201B (en) | Composition for removing pouch and fading black eye, and preparation method and application thereof | |
| CN115227620B (en) | Nourishing, moisturizing and skin brightening lotion and preparation method thereof | |
| CN115068389A (en) | Multi-effect composition, essence cream and preparation method thereof | |
| JP7305161B2 (en) | skin cosmetics | |
| CN112315866A (en) | Black plant extract and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231027 Address after: 510080 Room 502, building A3, No. 83, xueshantang street, Yongping street, Baiyun District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Lingkang Cosmetics Co.,Ltd. Address before: 528041 Guangdong city of Foshan province Chancheng Lanshi Stone Road No. 20 Patentee before: GUANGDONG VOCATIONAL AND TECHNICAL College |