CN111773151A - Whitening and freckle-removing antioxidant emulsion and preparation method thereof - Google Patents
Whitening and freckle-removing antioxidant emulsion and preparation method thereof Download PDFInfo
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- CN111773151A CN111773151A CN202010641611.XA CN202010641611A CN111773151A CN 111773151 A CN111773151 A CN 111773151A CN 202010641611 A CN202010641611 A CN 202010641611A CN 111773151 A CN111773151 A CN 111773151A
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- 239000000839 emulsion Substances 0.000 title claims abstract description 72
- 230000002087 whitening effect Effects 0.000 title claims abstract description 49
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 42
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 41
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 238000004945 emulsification Methods 0.000 title description 4
- 239000000284 extract Substances 0.000 claims abstract description 30
- 239000003755 preservative agent Substances 0.000 claims abstract description 29
- 230000002335 preservative effect Effects 0.000 claims abstract description 29
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- 239000002994 raw material Substances 0.000 claims abstract description 18
- -1 E10Liposome Substances 0.000 claims abstract description 14
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims abstract description 13
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims description 113
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 85
- 238000002156 mixing Methods 0.000 claims description 85
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 48
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- 229910021641 deionized water Inorganic materials 0.000 claims description 45
- 235000006708 antioxidants Nutrition 0.000 claims description 36
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 36
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 19
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Abstract
The invention provides a whitening and freckle-removing antioxidant emulsion and a preparation method thereof, and the raw materials comprise: glycyrrhiza glabra root extract, hydrogenated lecithin, E10Liposome, emulsifier and preservative. The emulsion disclosed by the invention has the effects of whitening and moisturizing the skin, is also beneficial to providing skin nutrition, has the effects of resisting wrinkles and aging, is mild in property, high in safety, free of side effects on the skin, and is suitable for long-term use.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a whitening and freckle-removing antioxidant emulsion and a preparation method thereof.
Background
With the increasing interest in beauty and skin health, the demand for cosmetics is rapidly increasing. Relevant data show that the number of the 'cosmetic population' in China is increased from 2200 million in 2005 to 1 hundred million in 2015, and the number of the 'cosmetic population' in China is estimated to be as high as 4 hundred million in 2025, which indicates that the cosmetic market in China has huge development potential. According to the statistics of the product structure in the global cosmetic industry in 2017, the skin care product accounts for 27%, the technical content of the product is continuously improved, and the mass consumption of the cosmetics is advanced to medium and high. Due to the continuous improvement of living standard and the acceleration of living rhythm of people, people put forward multiple requirements on individuation, convenience, high quality, high efficiency, natural health and the like on skin care products, so the skin care product market is one of the fastest-developing markets in the cosmetic industry.
The lotion contains a certain amount of water to supplement water for skin, and a small amount of oil to moisten skin. Traditional emulsion generally is the grease that uses the chemical synthesis, the grease content is unreasonable, be difficult to by skin absorption, lack the nourishing composition, it is not obvious to whiten the effect, and because the continuous improvement of people's living standard and the acceleration of life rhythm, people propose the multiple requirement of individuation, it is convenient, high-quality high efficiency, natural health etc. to skin care products, many whitening compositions, it has good effects to be confirmed, but the composition is unstable, and the antiseptic that adds has irritability to the skin, more and more women need safety, it is convenient to use, simplify the skin care product of skin care flow, consequently need one kind simultaneously have whiten, remove the macula, anti-aging, the skin care products of multiple efficiency such as nonirritant in order to solve above-mentioned problem urgently.
Disclosure of Invention
The invention aims to provide a whitening and freckle-removing antioxidant emulsion and a preparation method thereof, which are used for solving one or more technical problems in the prior art and at least providing a beneficial choice or creating conditions.
In order to realize the purpose, the technical scheme is as follows:
a whitening and freckle-removing antioxidant emulsion comprises the following raw materials: glycyrrhiza glabra root extract, hydrogenated lecithin, E10Liposome, emulsifier and preservative.
The emulsifiers were MONTANOV82 (cetearyl alcohol (and) cocoyl glucoside) and cetostearyl alcohol.
The preservative is a composition of at least two of caprylhydroxamic acid, 1, 2-hexanediol, caprylyl glycol and ethylhexyl glycerin.
The raw materials of the whitening and freckle-removing antioxidant emulsion comprise, by weight, 0.01-3 parts of glycyrrhiza glabra root extract, 0.1-1 part of hydrogenated lecithin, 0.2-1.6 parts of an emulsifier and 0.1-2.5 parts of a preservative.
The whitening and freckle-removing antioxidant emulsion also comprises the following raw materials: glycerin, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid, an amino acid humectant, dioctyl carbonate, plant squalane, tocopherol, acrylic acid/C10-30 alkanol acrylate crosspolymer, L-ascorbic acid 2-glucoside, potassium hydroxide, palmitoyl tetrapeptide-7, sodium hyaluronate, rose hydrosol, tris (hydroxymethyl) aminomethane, and sodium acrylate/sodium acryloyldimethyl taurate copolymer.
Wherein the sodium hyaluronate is 1% sodium hyaluronate solution.
The whitening and freckle-removing antioxidant emulsion comprises the following raw materials in parts by weight: 0.01-3 parts of glycyrrhiza glabra root extract, 1.1-35 parts of glycerol, 0.1-1 part of hydrogenated lecithin, 0.01-0.04 part of disodium ethylene diamine tetraacetate, 0.01-0.1 part of dipotassium glycyrrhizinate, 0.1-0.5 part of allantoin, 1-5 parts of nicotinamide, 1-3 parts of tranexamic acid, 0.5-2 parts of amino acid humectant, 0-0.6 part of MONTANOV820.1, 0.1-1 part of cetostearyl alcohol, 1-6 parts of dioctyl carbonate, 0.5-2 parts of plant squalane, 0.1-0.5 part of tocopherol, 0.1-0.3 part of acrylic acid (ester)/C10-30 parts of alkanol acrylate cross-linked polymer, 0.1-1 part of L-ascorbic acid 2-glucoside, 0.01-0.05 part of potassium hydroxide, 70.1-1 part of palmitoyl tetrapeptide, 0.1-2.5 parts of sodium hyaluronate solution, 10-1 part of Limepo, 0.1-2.5 parts of preservative, 1-3 parts of rose hydrosol, 0.05-0.5 part of tris (hydroxymethyl) aminomethane and 0.1-1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer.
The preparation method of the whitening and freckle-removing antioxidant emulsion is characterized by comprising the following specific steps:
(1) mixing Glycyrrhrizae radix extract with part of glycerol to obtain phase A;
(2) mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and amino acid humectant, and homogenizing to obtain phase C;
(4) adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1;
(5) mixing MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, heating for dissolving, and homogenizing to obtain phase D;
(6) heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E;
(7) heating, mixing and dissolving L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, and homogenizing to obtain an F phase;
(8) adding the mixed phase 1 into the phase D, mixing, heating and dissolving, adding the phase E and the phase F in sequence after homogenizing, then mixing, heating and homogenizing to obtain a mixed phase 2;
(9) mixing palmitoyl tetrapeptide-7, a sodium hyaluronate solution, E10Liposome, a preservative and rose hydrosol, heating and dissolving, and homogenizing to obtain a G phase;
(10) mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain an H phase;
(11) and respectively adding the phase G and the phase H into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion.
The ratio of the glycyrrhiza glabra rhizome extract to the glycerol in the step (1) is 1: 10.
the weight part of the deionized water added in the step (3) is 88-100 parts.
And (3) adding 1-3 parts of deionized water in the step (6).
The weight part of deionized water added in the step (7) is 1-3 parts.
The weight part of the deionized water added in the step (10) is 1-3 parts.
The heating and dissolving temperature in the step (3) is 60-75 ℃, the homogenizing speed is 2000-2500r/min, and the homogenizing time is 3-5 min.
The heating and dissolving temperature in the step (4) is 60-75 ℃, the homogenizing speed is 2000-2500r/min, and the homogenizing time is 3-5 min.
The heating and dissolving temperature in the step (5) is 60-75 ℃, the homogenizing speed is 4500-5200r/min, and the homogenizing time is 3-5 min.
The heating and dissolving temperature in the step (6) is 60-75 ℃, the homogenizing speed is 4500-5200r/min, and the homogenizing time is 1-3 min.
The heating and dissolving temperature in the step (7) is 50 ℃, the homogenizing speed is 4500-.
The temperature of the first mixing and heating in the step (8) is 70 ℃, the speed of the first homogenizing is 4500-.
The heating and dissolving temperature in the step (9) is 50 ℃, the homogenizing speed is 4500-.
The heating and dissolving temperature in the step (10) is 50 ℃, the homogenizing speed is 4500-.
The heating and dissolving temperature in the step (11) is 50 ℃, the homogenizing speed is 4500-.
The E10Liposome in the raw materials of the whitening and freckle-removing antioxidant emulsion can assist penetration of functional components by hydrogenated lecithin, reduce the problem that the functional components are difficult to absorb, and simultaneously has strong antioxidant effect, and the glycyrrhiza glabra rhizome extract has the whitening effect.
According to the invention, MONTANOV82 and cetostearyl alcohol are used as emulsifiers, a micro-emulsification system of a thermodynamically stable oil-water-surfactant-cosurfactant homogeneous system can be formed in the emulsion, and the stability of the emulsion is improved.
The emulsion disclosed by the invention is prepared by compounding the glycyrrhiza glabra rhizome extract, E10Liposome, hydrogenated lecithin, tranexamic acid, nicotinamide and L-ascorbic acid 2-glucoside, so that the skin whitening and moisturizing effect is achieved, meanwhile, the skin nutrition is provided, the anti-aging and freckle removing effects are achieved, the emulsion is mild in property, high in safety, free of side effects and stimulation on skin, and suitable for long-term use.
French seebeck emulsifiers of the invention: MONTANOV82, purchased from Kango corporation of July, Guangzhou.
The E10Liposome is purchased from Guangzhou Curie chemical technology, Inc., the E10Liposome is lecithin-wrapped product of 11 plant extracts, and the 11 plant extracts are respectively: bolinate Spirulina, Chlorella, rice germ, fructus Hordei vulgaris, fructus Hordei Germinatus, wild soybean sprout, semen Sesami sprout, fructus Hippophae, fructus Lycopersici Esculenti, fructus Punicae Granati, and folium Vaccinii Vitis-idaeae extract.
The invention has the beneficial effects that: the skin care lotion has multiple effects, simplifies the skin care process, adopts the emulsion state as a reference in the formula design, can achieve the multifunctional effects of toner, essence, emulsion, sleep mask and the like by taking the comfortable skin feeling and efficacy, selects a novel formula technology to ensure that the components can better permeate into the skin to play a role, selects the alcohol preservative to replace the conventional preservative to ensure the mildness of the product, selects the raw materials with relatively high stability, solves the problem of stability by compounding with other components, and greatly reduces the irritation to the skin.
Detailed Description
The following steps are only used for illustrating the technical scheme of the invention and are not limited; although the present invention has been described in detail with reference to the foregoing steps, it will be understood by those of ordinary skill in the art that: the technical solutions recorded in the foregoing steps may still be modified, or some or all of the technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the present invention in its various steps.
Example 1
The whitening and freckle-removing antioxidant emulsion comprises the following raw materials in percentage by weight: 0.01 part of glycyrrhiza glabra root extract, 1.1 part of glycerol, 0.1 part of hydrogenated lecithin, 0.01 part of ethylene diamine tetraacetic acid disodium, 0.01 part of dipotassium glycyrrhizinate, 0.1 part of allantoin, 1 part of nicotinamide, 1 part of tranexamic acid, 0.5 part of amino acid humectant, 820.1 parts of MONTANOV820.1 parts, 0.1 part of cetostearyl alcohol and 1 part of dioctyl carbonate, 0.5 part of plant squalane, 0.1 part of tocopherol, 0.1 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.1 part of L-ascorbic acid 2-glucoside, 0.01 part of potassium hydroxide, 70.1 parts of palmitoyl tetrapeptide, 0.1 part of 1% sodium hyaluronate solution, 0.1 part of E10Liposome, 0.1 part of preservative, 1 part of rose hydrosol, 0.05 part of tris (hydroxymethyl) aminomethane and 0.1 part of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of octyl glycol and ethylhexyl glycerol.
According to the raw materials and the addition amount, the preparation method of the whitening and freckle-removing antioxidant emulsion comprises the following specific steps:
(1) mixing the Glycyrrhiza glabra rhizome extract with partial glycerin to obtain phase A, wherein the ratio of the Glycyrrhiza glabra rhizome extract to the glycerin is 1: 10;
(2) mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and an amino acid humectant, and homogenizing to obtain a phase C, wherein the added weight part of the deionized water is 88 parts, the heating and dissolving temperature is 60 ℃, the homogenizing speed is 2000r/min, and the homogenizing time is 5 min;
(4) adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1, wherein the heating and dissolving temperature is 60 ℃, the homogenizing speed is 2000r/min, and the homogenizing time is 5 min;
(5) mixing, heating and dissolving MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, and homogenizing to obtain phase D, wherein the heating and dissolving temperature is 60 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 5 min;
(6) heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E, wherein the deionized water is added in 1 part by weight, the heating and dissolving temperature is 60 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 3 min;
(7) mixing L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, heating for dissolving, and homogenizing to obtain phase F, wherein the deionized water is added in 1 part by weight, the heating and dissolving temperature is 50 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 1 min;
(8) adding the mixed phase 1 into the phase D, mixing and heating at 70 ℃ for dissolving, homogenizing at 4500r/min, sequentially adding the phase E and the phase F, mixing and heating at 50 ℃, and homogenizing at 4800r/min for 1min to obtain a mixed phase 2;
(9) mixing, heating and dissolving palmitoyl tetrapeptide-7, a sodium hyaluronate solution, E10Liposome, a preservative and rose hydrosol, and homogenizing to obtain a G phase, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 1 min;
(10) mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain H phase, wherein the weight part of deionized water is 1 part, the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 2 min;
(11) and sequentially adding the G phase and the H phase into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4500r/min, and the homogenizing time is 2 min.
Example 2
The whitening and freckle-removing antioxidant emulsion comprises the following raw materials in percentage by weight: 3 parts of glycyrrhiza glabra root extract, 35 parts of glycerol, 1 part of hydrogenated lecithin, 0.04 part of ethylene diamine tetraacetic acid disodium, 0.1 part of dipotassium glycyrrhizinate, 0.5 part of allantoin, 5 parts of nicotinamide, 3 parts of tranexamic acid, 2 parts of amino acid humectant, 0 part of MONTANOV 820.6, 1 part of hexadecanol, 6 parts of dioctyl carbonate, 2 parts of plant squalane, 0.5 part of tocopherol, 0.3 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 1 part of L-ascorbic acid 2-glucoside, 0.05 part of potassium hydroxide, 71 parts of palmitoyl tetrapeptide, 2.5 parts of 1% sodium hyaluronate solution, 1 part of E10Liposome, 2.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a combination of caprylhydroxamic acid, 1, 2-hexanediol, caprylyl glycol and ethylhexylglycerin.
According to the raw materials and the addition amount, the preparation method of the whitening and freckle-removing antioxidant emulsion comprises the following specific steps:
(1) mixing the Glycyrrhiza glabra rhizome extract with partial glycerin to obtain phase A, wherein the ratio of the Glycyrrhiza glabra rhizome extract to the glycerin is 1: 10;
(2) mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and amino acid humectant, and homogenizing to obtain phase C, wherein the weight part of deionized water is 100 parts, the heating and dissolving temperature is 75 ℃, the homogenizing speed is 2500r/min, and the homogenizing time is 3 min;
(4) adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1, wherein the heating and dissolving temperature is 75 ℃, the homogenizing speed is 2000r/min, and the homogenizing time is 5 min;
(5) mixing, heating and dissolving MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, and homogenizing to obtain phase D, wherein the heating and dissolving temperature is 75 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 3 min;
(6) heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E, wherein the deionized water is added in 3 parts by weight, the heating and dissolving temperature is 75 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1 min;
(7) mixing L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, heating for dissolving, and homogenizing to obtain phase F, wherein the deionized water is added in 3 parts by weight, the heating and dissolving temperature is 50 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1 min;
(8) adding the mixed phase 1 into the phase D, mixing and heating at 70 ℃ for dissolution, homogenizing at 5200r/min, sequentially adding the phase E and the phase F, mixing and heating at 50 ℃, and homogenizing at 5000r/min for 1min to obtain a mixed phase 2;
(9) mixing, heating and dissolving palmitoyl tetrapeptide-7, 1% sodium hyaluronate solution, E10Liposome, preservative and rose hydrosol, and homogenizing to obtain G phase, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1 min;
(10) mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain H phase, wherein the added weight part of deionized water is 1 part, the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1 min;
(11) sequentially adding the G phase and the H phase into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5200r/min, and the homogenizing time is 1 min.
Example 3
The whitening and freckle-removing antioxidant emulsion comprises the following raw materials in percentage by weight: 2 parts of glycyrrhiza glabra root extract, 25 parts of glycerol, 0.5 part of hydrogenated lecithin, 0.03 part of ethylene diamine tetraacetic acid, 0.06 part of dipotassium glycyrrhizinate, 0.3 part of allantoin, 3 parts of nicotinamide, 2 parts of tranexamic acid, 1.5 parts of amino acid humectant, 0.5 part of MONTANOV 820.4 part, 0.5 part of cetostearyl alcohol and 4 parts of dioctyl carbonate, 1.5 parts of plant squalane, 0.3 part of tocopherol, 0.2 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.6 part of L-ascorbic acid 2-glucoside, 0.03 part of potassium hydroxide, 70.6 parts of palmitoyl tetrapeptide, 1.8 parts of 1% sodium hyaluronate solution, 0.5 part of E10Liposome, 1.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylyl hydroximic acid and 1, 2-hexanediol.
According to the raw materials and the addition amount, the preparation method of the whitening and freckle-removing antioxidant emulsion comprises the following specific steps:
(1) mixing the Glycyrrhiza glabra rhizome extract with partial glycerin to obtain phase A, wherein the ratio of the Glycyrrhiza glabra rhizome extract to the glycerin is 1: 10;
(2) mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and an amino acid humectant, and homogenizing to obtain a phase C, wherein the added weight part of the deionized water is 95 parts, the heating and dissolving temperature is 70 ℃, the homogenizing speed is 2300r/min, and the homogenizing time is 4 min;
(4) adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1, wherein the heating and dissolving temperature is 70 ℃, the homogenizing speed is 2300r/min, and the homogenizing time is 4 min;
(5) mixing MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, heating for dissolving, and homogenizing to obtain phase D, wherein the heating and dissolving temperature is 70 deg.C, the homogenizing speed is 5000r/min, and the homogenizing time is 4 min;
(6) heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E, wherein the deionized water is added in 2 parts by weight, the heating and dissolving temperature is 70 ℃, the homogenizing speed is 4900r/min, and the homogenizing time is 2 min;
(7) mixing L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, heating for dissolving, and homogenizing to obtain phase F, wherein the deionized water is added in 2 parts by weight, the heating and dissolving temperature is 50 ℃, the homogenizing speed is 5100r/min, and the homogenizing time is 1 min;
(8) adding the mixed phase 1 into the phase D, mixing and heating at 70 ℃ for dissolving, homogenizing at 4800r/min, sequentially adding the phase E and the phase F, mixing and heating at 50 ℃, and homogenizing at 4900r/min for 1min to obtain a mixed phase 2;
(9) mixing, heating and dissolving palmitoyl tetrapeptide-7, 1% sodium hyaluronate solution, E10Liposome, preservative and rose hydrosol, and homogenizing to obtain a G phase, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4700r/min, and the homogenizing time is 1 min;
(10) mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain H phase, wherein the added weight part of deionized water is 2 parts, the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5000r/min, and the homogenizing time is 2 min;
(11) and sequentially adding the phase G and the phase H into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4800r/min, and the homogenizing time is 2 min.
Further effect tests were conducted on the above examples 1 to 3.
First, stability detection
The emulsion is a thermodynamically unstable system, and an over-acceleration test, a real-time test and a rheological measurement are carried out to ensure that the product is stable and safe within the shelf life.
Comparative example 1: an emulsion, comprising: 2 parts of glycyrrhiza glabra root extract, 25 parts of glycerol, 0.5 part of hydrogenated lecithin, 0.03 part of ethylene diamine tetraacetic acid, 0.06 part of dipotassium glycyrrhizinate, 0.3 part of allantoin, 3 parts of nicotinamide, 2 parts of tranexamic acid, 1.5 parts of an amino acid humectant, 4 parts of dioctyl carbonate, 1.5 parts of plant squalane, 0.3 part of tocopherol, 0.2 part of acrylic acid/C10-30 alkanol acrylate cross-linked polymer, 0.6 part of L-ascorbic acid 2-glucoside, 0.03 part of potassium hydroxide, 70.6 parts of palmitoyl tetrapeptide, 1% sodium hyaluronate solution 1.8 parts, 0.5 part of E10Liposome, 1.5 parts of a preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylyl hydroxamic acid and 1, 2-hexanediol.
Comparative example 2: an emulsion, comprising: 2 parts of glycyrrhiza glabra root extract, 25 parts of glycerol, 0.5 part of hydrogenated lecithin, 0.03 part of ethylene diamine tetraacetic acid, 0.06 part of dipotassium glycyrrhizinate, 0.3 part of allantoin, 3 parts of nicotinamide, 2 parts of tranexamic acid, 1.5 parts of amino acid humectant, 0.5 part of cetostearyl alcohol and 4 parts of dioctyl carbonate, 1.5 parts of plant squalane, 0.3 part of tocopherol, 0.2 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.6 part of L-ascorbic acid 2-glucoside, 0.03 part of potassium hydroxide, 70.6 parts of palmitoyl tetrapeptide, 1.8 parts of 1% sodium hyaluronate solution, 0.5 part of E10Liposome, 1.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylyl hydroximic acid and 1, 2-hexanediol.
Comparative example 3: an emulsion, comprising: 2 parts of glycyrrhiza glabra root extract, 25 parts of glycerol, 0.5 part of hydrogenated lecithin, 0.03 part of ethylene diamine tetraacetic acid, 0.06 part of dipotassium glycyrrhizinate, 0.3 part of allantoin, 3 parts of nicotinamide, 2 parts of tranexamic acid, 1.5 parts of amino acid humectant, 0.2 part of MONTANOV 820.4, 4 parts of dioctyl carbonate, 1.5 parts of plant squalane, 0.3 part of tocopherol, 0.2 part of acrylic acid/C10-30 alkanol acrylate cross-linked polymer, 0.6 part of L-ascorbic acid 2-glucoside, 0.03 part of potassium hydroxide, 70.6 parts of palmitoyl tetrapeptide-1, 1% sodium hyaluronate solution 1.8 parts, 0.5 part of E10Liposome, 1.5 parts of preservative, 3 parts of rose hydrosol, 0.5 part of tris (hydroxymethyl) aminomethane and 1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer, wherein the preservative is a composition of caprylyl hydroxamic acid and 1, 2-hexanediol.
The preparation method of the emulsion described in the above comparative examples 1 to 3 specifically comprises the steps of:
(1) mixing the Glycyrrhiza glabra rhizome extract with partial glycerin to obtain phase A, wherein the ratio of the Glycyrrhiza glabra rhizome extract to the glycerin is 1: 10;
(2) mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and an amino acid humectant, and homogenizing to obtain a phase C, wherein the added weight part of the deionized water is 95 parts, the heating and dissolving temperature is 70 ℃, the homogenizing speed is 2300r/min, and the homogenizing time is 4 min;
(4) adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1, wherein the heating and dissolving temperature is 70 ℃, the homogenizing speed is 2300r/min, and the homogenizing time is 4 min;
(5) mixing, heating and dissolving dioctyl carbonate, plant squalane and tocopherol (hexadecanol with the corresponding addition amount is added in the preparation of comparative example 2, MONTANOV82 with the corresponding addition amount is added in the preparation of comparative example 3), and homogenizing to obtain a D phase, wherein the heating and dissolving temperature is 70 ℃, the homogenizing speed is 5000r/min, and the homogenizing time is 4 min;
(6) heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E, wherein the deionized water is added in 2 parts by weight, the heating and dissolving temperature is 70 ℃, the homogenizing speed is 4900r/min, and the homogenizing time is 2 min;
(7) mixing L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, heating for dissolving, and homogenizing to obtain phase F, wherein the deionized water is added in 2 parts by weight, the heating and dissolving temperature is 50 ℃, the homogenizing speed is 5100r/min, and the homogenizing time is 1 min;
(8) adding the mixed phase 1 into the phase D, mixing and heating at 70 ℃ for dissolving, homogenizing at 4800r/min, sequentially adding the phase E and the phase F, mixing and heating at 50 ℃, and homogenizing at 4900r/min for 1min to obtain a mixed phase 2;
(9) mixing, heating and dissolving palmitoyl tetrapeptide-7, 1% sodium hyaluronate solution, E10Liposome, preservative and rose hydrosol, and homogenizing to obtain a G phase, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4700r/min, and the homogenizing time is 1 min;
(10) mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain H phase, wherein the added weight part of deionized water is 2 parts, the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 5000r/min, and the homogenizing time is 2 min;
(11) and sequentially adding the phase G and the phase H into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion, wherein the mixing, heating and dissolving temperature is 50 ℃, the homogenizing speed is 4800r/min, and the homogenizing time is 2 min.
Comparative example 4: an emulsion, comprising: 7 parts of 1, 3-butanediol, 5 parts of betaine, 3 parts of 1, 2-pentanediol, 3 parts of squalane, 3 parts of polydimethylsiloxane, 2.5 parts of cetostearyl alcohol, 2 parts of glycerol, 1 part of sucrose stearate, 1 part of sucrose distearate, 0.6 part of isononyl isononanoate, 0.05 part of sodium bis (lauramide glutamine) lysine, 20.5 parts of bis-diglycerol polyacyladipate, 0.3 part of PEG-45 stearate, 0.0015 part of beta-glucan, 0.2 part of arginine, 0.2 part of polyacrylic acid, 0.0025 part of hydrolyzed vegetable protein, 0.0025 part of adenosine triphosphate, 0.0025 part of sodium chondroitin sulfate, 0.8978 part of MONTANOV 820.4 part, 0.5 part of hexadecanol, 0.01 part of sodium citrate, 0.003 part of citric acid, 0.00002 part of denatonium benzoate and 1 part of macadamia seed oil.
Comparative example 5: an emulsion, comprising: 7 parts of 1, 3-butanediol, 5 parts of betaine, 3 parts of 1, 2-pentanediol, 3 parts of squalane, 3 parts of polydimethylsiloxane, 2.5 parts of cetostearyl alcohol, 2 parts of glycerol, 1 part of sucrose stearate, 1 part of sucrose distearate, 0.6 part of isononyl isononanoate, 0.05 part of sodium bis (lauramide glutamine) lysine, 20.5 parts of bis-diglycerol polyacyladipate, 0.3 part of PEG-45 stearate, 0.0015 part of beta-glucan, 0.2 part of arginine, 0.2 part of polyacrylic acid, 0.0025 part of hydrolyzed vegetable protein, 0.0025 part of adenosine triphosphate, 0.0025 part of sodium chondroitin sulfate, 0.01 part of sodium citrate, 0.003 part of citric acid, 0.00002 part of denatonium benzoate and 1 part of macadamia nut oil.
Accelerated testing: experimental groups: the emulsions described in examples 1 to 3 and comparative examples 1 to 5 were stored at 50 ℃ for 24 hours and at room temperature for 24 hours, respectively; control group: the emulsions prepared in examples 1 to 3 and comparative example 1 were stored at room temperature for 48 hours, and changes in aggregation and flocculation, appearance and viscosity were observed by light reflection.
And (3) real-time experiment: the emulsions described in examples 1 to 3 and comparative examples 1 to 5 above were observed for changes in appearance, odor, and the like at different times depending on the initial characteristics upon long-term storage without applying a load to the emulsions.
And (3) centrifugal experiment: the emulsions of examples 1 to 3 and comparative examples 1 to 5 were placed in a centrifuge, respectively, and tested at a rotation speed of 4000r/min for 30min to observe the separation and delamination of the emulsions of examples 1 to 3 and comparative examples 1 to 5.
The results are shown in table 1, the whitening, freckle removing and antioxidant emulsions prepared in examples 1, 2 and 3 have no abnormality and no obvious change when compared with a control group through an accelerated test, while the emulsions described in comparative example 1 have reduced viscosity and flocculation, the emulsions described in comparative example 2 have reduced viscosity but no flocculation, and the emulsions described in comparative examples 3 and 4 have no abnormality and the emulsions described in comparative example 5 have reduced viscosity and flocculation; the whitening and freckle-removing antioxidant emulsions prepared in examples 1, 2 and 3 have no abnormal appearance, smell and layering phenomenon after the implementation test and the centrifugation test, while the emulsion described in comparative example 1 has changed smell after two months and has layering phenomenon after the centrifugation test; the odor of the comparative example 2 changes after 4 months, and the odor of the comparative example 3 changes after five months, so that the layering phenomenon occurs; comparative example 4 smell changed over three months, delamination occurred; comparative example 5 changed odor over a period of one month and delamination occurred. Therefore, MONTANOV82 and hexadecanol are used as emulsifying agents, a micro-emulsification system of a thermodynamically stable oil-water-surfactant-cosurfactant homogeneous system can be formed in the emulsion, and the stability of the emulsion is improved, so that the whitening and freckle-removing antioxidant emulsion has good stability.
TABLE 1 stability test results
Second, sensory evaluation
60 persons were selected and divided into 3 groups on average, and the whitening and spot-removing antioxidant emulsions prepared in example 1, example 2 and example 3 were subjected to sensory evaluation from sampling, painting and after-use feeling, respectively.
Sampling: the sensory properties evaluated were consistency, perceived ease of removal, which can be divided into three grades: low consistency, medium consistency and high consistency.
Smearing: the effect was evaluated by gently moving the skin in a circular motion at a rate of two revolutions per second, followed by rubbing the skin for a further period of time. Mainly including dispersibility and absorbability.
Feeling after use: after the product was applied to the skin, the type of residue on the skin and a description of the skin feel of the product were judged.
The results are shown in table 2, and it can be seen that the whitening and freckle-removing antioxidant emulsion of the invention is mild and non-irritating after being used, is relatively refreshing and light and thin when being used, and is fast to absorb and non-sticky.
TABLE 2 sensory evaluation
Third, efficacy test
Comparative example 6: the commercially available whitening and freckle-removing emulsion containing glycyrrhiza glabra rhizomes comprises the following raw materials: water, butylene glycol, glycerol tri (ethylhexanoate), glycerol, neopentyl glycol dicaprate, ascorbyl glucoside, glyceryl stearate SE, sodium hyaluronate, phenoxyethanol, methylparaben, polyglyceryl-10 myristate, cetostearyl alcohol, cetostearyl glucoside, quince (PYRUS CYDONIA) seed extract, sodium citrate, behenyl alcohol hydrogenated lecithin, sorbitan polyether-60 tetraoleate, xanthan gum, potassium hydroxide, polydimethylsiloxane, serine, sodium stearyl glutamate, propylparaben, trehalose, disodium EDTA, stearyl glycyrrhetate, tocopheryl acetate, GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root extract, tocopherol (vitamin E) soyabean (GLYCINE SOJA) oil, citric acid, rosa canina (rosa canina) fruit oil.
The whitening and freckle-removing antioxidant emulsion described in example 1, example 2 and example 3 and comparative example 6 were subjected to performance measurement, and 80 testers with darker skin colors were selected, and the testers were half of each male and female. Groups were randomized into 4 groups of 10 males and 10 females. 4 groups of the emulsion described in example 1, the emulsion described in example 2, the emulsion described in example 3 and the emulsion described in comparative example 6 were used, respectively. The application method is that the skin whitening and freckle removing cream is used after face cleaning every day, once a day, the experimental period is 30 days, and a trial evaluation table is filled according to the whitening and freckle removing antioxidant effects of the cream (wherein an experimenter adopts a grading system, the highest score is 10, the representation effect is obvious, 5 represents that the effect is general, and the lowest score is 1, the representation effect is not effective). The administration was counted once on each of day 5, 10, 15, 20, 25 and 30.
The evaluation result statistics are shown in table 3, and it can be seen that the whitening and freckle removing antioxidant emulsion has a remarkable whitening and freckle removing antioxidant effect, and has a remarkable effect compared with the commercially available whitening and freckle removing emulsion containing glycyrrhiza glabra rhizomes. The whitening and freckle-removing antioxidant emulsion disclosed by the invention is comfortable in skin feel, free of irritation, remarkable in whitening effect and healthy and clear in skin after whitening.
TABLE 3 evaluation statistics
| Day 5 | Day 10 | Day 15 | Day 20 | Day 25 | Day 30 | |
| Example 1 | 2 | 3 | 5 | 6 | 7 | 7 |
| Example 2 | 2 | 4 | 6 | 7 | 8 | 8 |
| Example 3 | 2 | 4 | 6 | 8 | 8 | 9 |
| Comparative example 6 | 2 | 4 | 5 | 7 | 7 | 7 |
Claims (9)
1. The whitening and freckle-removing antioxidant emulsion is characterized by comprising the following raw materials: glycyrrhiza glabra root extract, hydrogenated lecithin, E10Liposome, emulsifier and preservative.
2. The whitening spot-removing antioxidant emulsion of claim 1, wherein the emulsifier is MONTANOV82 and cetostearyl alcohol.
3. The whitening and freckle-removing antioxidant emulsion according to claim 1, wherein the preservative is a combination of at least two of caprylhydroxamic acid, 1, 2-hexanediol, caprylyl glycol and ethylhexyl glycerin.
4. The whitening and freckle-removing antioxidant emulsion as claimed in claim 1, wherein the raw materials comprise, by weight, 0.01-3 parts of glycyrrhiza glabra root extract, 0.1-1 parts of hydrogenated lecithin, 0.6-0.78 parts of MONTANOV820.1, 0.1-1 parts of cetostearyl alcohol and 0.1-2.5 parts of preservative.
5. The whitening and freckle-removing antioxidant emulsion according to claim 1, wherein the raw materials further comprise: glycerin, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid, an amino acid humectant, dioctyl carbonate, plant squalane, tocopherol, acrylic acid/C10-30 alkanol acrylate crosspolymer, L-ascorbic acid 2-glucoside, potassium hydroxide, palmitoyl tetrapeptide-7, sodium hyaluronate, rose hydrosol, tris (hydroxymethyl) aminomethane, and sodium acrylate/sodium acryloyldimethyl taurate copolymer.
6. The whitening and freckle-removing antioxidant emulsion according to claim 1 is characterized by comprising the following raw materials in parts by weight: 0.01-3 parts of glycyrrhiza glabra root extract, 1.1-35 parts of glycerol, 0.1-1 part of hydrogenated lecithin, 0.01-0.04 part of disodium ethylene diamine tetraacetate, 0.01-0.1 part of dipotassium glycyrrhizinate, 0.1-0.5 part of allantoin, 1-5 parts of nicotinamide, 1-3 parts of tranexamic acid, 0.5-2 parts of amino acid humectant, 0-0.6 part of MONTANOV820.1, 0.1-1 part of cetostearyl alcohol, 1-6 parts of dioctyl carbonate, 0.5-2 parts of plant squalane, 0.1-0.5 part of tocopherol, 0.1-0.3 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.1-1 part of L-ascorbic acid 2-glucoside, 0.01-0.05 part of potassium hydroxide, 70.1-1 part of palmitoyl tetrapeptide, 0.1-2.5 parts of sodium hyaluronate, 10-1.1 part of Lipome, 0.1-2.5 parts of preservative, 1-3 parts of rose hydrosol, 0.05-0.5 part of tris (hydroxymethyl) aminomethane and 0.1-1.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer.
7. The preparation method of the whitening and freckle-removing antioxidant emulsion according to any one of claims 1 to 6, wherein the preparation method comprises the following specific steps:
(1) mixing Glycyrrhrizae radix extract with part of glycerol to obtain phase A;
(2) mixing the rest glycerol with hydrogenated lecithin to obtain phase B;
(3) heating and dissolving deionized water, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, allantoin, nicotinamide, tranexamic acid and amino acid humectant, and homogenizing to obtain phase C;
(4) adding the phase B into the phase C, mixing and heating, then adding the phase A, heating for dissolving, and homogenizing; obtaining a mixed phase 1;
(5) mixing MONTANOV82, cetostearyl alcohol, dioctyl carbonate, plant squalane and tocopherol, heating for dissolving, and homogenizing to obtain phase D;
(6) heating, mixing and dissolving acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and deionized water, and homogenizing to obtain phase E;
(7) heating, mixing and dissolving L-ascorbic acid 2-glucoside, potassium hydroxide and deionized water, and homogenizing to obtain an F phase;
(8) adding the mixed phase 1 into the phase D, mixing, heating and dissolving, adding the phase E and the phase F in sequence after homogenizing, then mixing, heating and homogenizing to obtain a mixed phase 2;
(9) mixing palmitoyl tetrapeptide-7, sodium hyaluronate, E10Liposome, preservative and rose hydrosol, heating for dissolving, and homogenizing to obtain a G phase;
(10) mixing, heating and dissolving trihydroxymethyl aminomethane and deionized water, and homogenizing to obtain an H phase;
(11) and respectively adding the phase G and the phase H into the mixed phase 2, mixing and heating, homogenizing, then adding the sodium acrylate/sodium acryloyldimethyl taurate copolymer, mixing and heating, and finally homogenizing to obtain the whitening and freckle-removing antioxidant emulsion.
8. The method according to claim 7, wherein the ratio of the glycyrrhiza glabra rhizome extract to the glycerin added in the step (1) is 1: 10.
9. the method according to claim 7, wherein the deionized water is added in the step (3) in an amount of 88 to 100 parts by weight.
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