CN104188859A - Anti-wrinkle skin-tendering emulsion containing natural component extracts and preparation method thereof - Google Patents
Anti-wrinkle skin-tendering emulsion containing natural component extracts and preparation method thereof Download PDFInfo
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- CN104188859A CN104188859A CN201410424269.2A CN201410424269A CN104188859A CN 104188859 A CN104188859 A CN 104188859A CN 201410424269 A CN201410424269 A CN 201410424269A CN 104188859 A CN104188859 A CN 104188859A
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Abstract
The invention discloses an anti-wrinkle skin-tendering emulsion containing natural component extracts and a preparation method thereof. The emulsion is prepared from the following substances: grape seed oil, wheat-germ oil, broccoli juice, pea shoot juice, nicotinamide, vitamin C, synthetic squalane, sodium alginate, carbomer, poloxamer, a self-emulsified compound emulsifier, glycerol, triethanolamine, a 10% ethylenediamine tetraacetic acid disodium solution, a 20% methylparaben alcoholic solution and distilled water. Compared with the prior art, the emulsion has the characteristics of mild property and high safety, O/W type emulsion with uniform and fine texture, freshness without greasy feeling can be prepared by adopting a method of combining natural component extracts and plant essential oil. The emulsion is capable of firming skin and smoothing wrinkles, and exerting certain effects of removing spots, whitening and nourishing, so that the tender and moistened activity of skin can be rejuvenized.
Description
Technical field
The present invention relates to face beautifying medicine and learn field, be specifically related to a kind of crease-resistant skin care emulsion and preparation method thereof.
Background technology
Skin aging is a kind of progressive physiological process, direct cutaneous outward appearance and function of continuing.Wrinkle is a kind of sign of skin aging, is called as " annual ring of life ".People in the modern life are experiencing for a long time intensive work, are being exposed to the contour radiation of computer cell phone and ultraviolet radiation environment, make originally, with age growth dim skin aging more obvious day by day, to form little microgroove, wrinkle.
The generation of wrinkle is summed up four reasons: natural aging, centrifugal force, photoaging and photic damage, the too much contraction of facial expression muscle.Wherein the most key factor is natural aging and two kinds of forms of photoaging, and the former mainly refers to advancing age, the irresistible factor existing in body, as heredity, gravity, endocrine and immunologic function etc. cause aging; The latter, mainly due to ultraviolet effect, has increased the weight of the process of naturally-aged.Relaxing day by day appears in skin, attenuation, water content decline, and seems dry, has squama, tarnishes; Elasticity and consolidation also decline thereupon; Wrinkle forms, and increases gradually, deepens.In addition, the sensitivity of skin increases, and pigment also increases.The inherence of skin aging shows as skin cell proliferation ability and declines, and epidermal renewal speed slows down, and skin reconstruction ability weakens, and skin collagen is synthetic to slow down, and skin immunization power declines, pigment skewness etc.
Along with the raising of quality of life, people pursue beautiful desire to be increased day by day, anti-agingly dispels wrinkle, returns to the hot topic that the youth has become the vast women of liking to be beautiful.Defying age will be accomplished " preventing trouble before it happens ", promoting the various environmental stimuli effects limit that wrinkle occurs to arrive floor level, is only the effective way that prevents and smooth away wrinkles.First the Diet lifestyle that yes keeps fit, keeps happy mood, guarantees sufficient sleep, and body and mind relaxing, slows down pressure, could keep skin health.In addition, choose dexterously the emulsion of a applicable skin and adhere to that daily nursing is the requisite key of beautiful skin.
On market, in more existing emulsions, add the chemosynthesis material that is harmful to skin, temporary transient bright and new beautiful but giving left huge skin hidden danger later.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of crease-resistant skin care emulsion containing natural component extract, add natural extract composition, not containing any hormone and harmful chemical, to skin zero damage, non-stimulated, alleviate skin aging effect more obvious.
The present invention also provides a kind of preparation method of the crease-resistant skin care emulsion containing natural component extract.
A kind of crease-resistant skin care emulsion containing natural component extract provided by the invention, contains following material in the crease-resistant skin care emulsion of 150g:
Described Sucus Caulis et Folium Brassicae capitatae is prepared by the following method:
Choose fresh Caulis et Folium Brassicae capitatae, with distilled water, clean, be cut into little, with gradation after distilled water immersion 0.3-0.5h, squeeze the juice, get Caulis et Folium Brassicae capitatae appropriate and add 3-6 doubly to measure distilled water to squeeze at every turn, merge the Sucus Caulis et Folium Brassicae capitatae that gradation is squeezed, with clean double gauze filter 23-5 time, to remove the residue in juice, clear filtrate after filtering is merged, and volume is concentrated into 3-5 times of g/ml of Caulis et Folium Brassicae capitatae weight, then uses double gauze filter 23-5 time, remove the residue of separating out in concentrated juice, make Sucus Caulis et Folium Brassicae capitatae standby.
Described pea seedlings juice is prepared by the following method:
Choose fresh pea seedlings, with distilled water, clean, be cut into segment, with after distilled water immersion 0.3-0.5h, gradation is squeezed the juice, get pea seedlings appropriate and add 2-4 doubly to measure distilled water to squeeze at every turn, merge the pea seedlings juice that gradation is squeezed, with clean double gauze filter 23-5 time, to remove the residue in juice, clear filtrate after filtering is merged, volume is concentrated into 2-4 times of g/ml of pea seedlings weight, then uses double gauze filter 23-5 time, removes the residue of separating out in concentrated juice, make pea seedlings juice, standby.
The preparation method of a kind of crease-resistant skin care emulsion containing natural component extract provided by the invention, comprises the following steps:
A) take sodium alginate 1.5-4.5g, add distilled water 30-70ml, heating in water bath, to 60-80 ℃, heats while stirring, and after mix homogeneously, standing its abundant swelling that allows, is clear gel, standby;
B) take carbomer 1.0-2.0g, add distilled water 60-100ml, heating in water bath is to 60-80 ℃, and limit heating edge stirs rapidly, standing allowing after its abundant swelling, dropwise adds the neutralization of 1.0-2.0g triethanolamine, and limit adds surveys pH value while stirring, when PH=7, be clear gel, standby;
C) get respectively Oleum Vitis viniferae 1.0-5.0ml, Semen Tritici aestivi germ oil 1.0-5.0ml, synthetic squalane 0.5-3.0ml, three is uniformly mixed, add again self emulsifying mixed emulsifier 0.5-7.5g, heating in water bath in 70-80 ℃, heat while stirring and make its mix homogeneously, obtain the oil phase of O/W type emulsion;
D) take poloxamer 0.5-5.0g, add 15-30ml distilled water, heating in water bath in 70-80 ℃, heats while stirring, and it is dissolved completely, obtains the water in O/W type emulsion;
E) measure respectively Sucus Caulis et Folium Brassicae capitatae and the pea seedlings juice 1.0-5.0ml of preparation, stirred, as the main composition of emulsion;
F) take respectively 10% disodium ethylene diamine tetra-acetic acid solution 0.01-0.5g, 20% methyl hydroxybenzoate alcoholic solution 0.01-0.5mg, add glycerol 1.0-8.0ml, stir and make its mix homogeneously, as the antiseptic in emulsion and wetting agent;
G) in 70-80 ℃ of water-bath, Deng oil phase, when water reaches uniform temp, by step c) oil phase prepared is thread shape and slowly joins steps d along walls of beaker) in the water prepared, limit heating edge at the uniform velocity stirs along same side, after 15-30min, emulsifying completes, obtain O/W type emulsion, until emulsion, stir and be cooled to after room temperature, add each 0.1-0.5g of vitamin C and nicotiamide, step e) Sucus Caulis et Folium Brassicae capitatae mixing of preparing and pea seedlings juice, step f) antiseptic of preparing and wetting agent, the sodium alginate gel that step a) is prepared and step b) carbomer gel prepared stirs.
In the present invention, each composition is as follows:
Caulis et Folium Brassicae capitatae contains abundant vitamin C, A, K, and as a kind of free radical scavenger, vitamin C can be brought into play anti-oxidation function, thereby strengthen the skin stress ability of environment to external world, strengthen skin immunization power, improve the resistivity of skin to hostile environment, also can remove the toxicity of noxious substance.Vitamin A can make skin keep elasticity, and can make skin have anti-damage ability, can delay skin aging, there is stronger beautification function.The basic reason of skin-cell aging be cell through the oxidative damage of metabolic process, Caulis et Folium Brassicae capitatae has the ability of removing more by force DPPH free radical, and its water-soluble extracting liquid to remove the fat-soluble extracting solution ability of energy force rate of free radical stronger.
Pea seedlings can be treated tanned skin, makes the salubrious non-greasy of skin.Pea seedlings contains the nutrient substance such as carotene, ascorbic acid, riboflavin.In the tender leaf of pea seedlings, be rich in vitamin C and can decomposer in the enzyme of nitrosamine, can decomposing nitrosamine, there is the effect of anti-cancer and cancer-preventing.The materials such as the acid of only wooden fork, gibberellins and the solidifying element of plant that Semen Pisi sativi is contained, have anti-inflammation, strengthen the function of skin metabolism.The vitamin E that pea seedlings is contained and Semen Pisi sativi polysaccharide all have antioxidation, anti-aging obvious effect, and the vitamin B containing can be used as the use of Glycerin.
Oleum Vitis viniferae, as good base oil, is easily absorbed by the skin.It has gentle astringency, can help to tighten and nursing skin.It is rich in linoleic acid, is a kind of essential fatty acid, extremely important to skin and cell membrane.Oleum Vitis viniferae has regeneration and the effect of making contributions again, and skin is had to very strong moisture-keeping function.As one of the most efficient antioxidant, there is the powerful effect of removing free radical, improving body immunity.It is containing enriching bioflavonoids, being powerful elite molecule, for resisting freedom and the health of safeguarding microfilament blood vessel.Its contained a large amount of oligomeric proanthocyanidin OPC, energy protecting human bodies skin, avoids free radical invasion and attack; This function makes skin increase elasticity, not encroached on by adverse circumstances.Semen Vitis viniferae extract not only has the effect of slow down aging, or natural sunlight overcover, can encroach on skin by shielding of ultraviolet, can also repair injured collagen protein and elastic fiber.Semen Vitis viniferae extract has astriction, tightens up skin, prevents occurring ahead of time of wrinkle of skin, and life-time service can make skin smooth, and high resilience has the effect of looks improving and the skin nourishing.
Semen Tritici aestivi germ oil has been concentrated the nutrition elite of Semen Tritici aestivi, and rich in vitamin E, linoleic acid, linolenic acid and multiple physiologically active component, have very high nutritive value.The hat that particularly content of vitamin E is vegetable oil, has been acknowledged as a kind of functional grease that has much nutrition health-care functions.Its physiologically active usefulness is 30 times of synthesising complex E, is natural antioxidant, and is easily absorbed by the body.Prevent in vivo the generation of lipid oxide, Cell protection film, suppresses free radical, promotes human body metabolism, delays body aging, can strengthen the connective tissue of skin, promotes blood circulation and keeps skin elasticity, is best suited for old and feeble and ripe skin.The characteristic of its free radical resisting, can delay skin aging; Moistness is strong, can desalinate microgroove, striae gravidarum, cicatrix, increases skin wetting power, to dry, hydropenia, aging, wrinkle skin is extremely helpful.Can reduce the left vestige of long comedo on the face.Be applicable to various skin quality, black speck, chronic eczema, eczema are had to certain effect, also there is sun-screening function, can be used for antitan agent.
Squalane is that rare chemical stability is high, and the animal oil that use sense is splendid has good affinity to skin, can not cause allergy and stimulation, and can accelerate other active component in formula and permeate in skin; There is lower polarity and medium spreadability, and pure, colourless, free from extraneous odour; Growth that also can mould fungus inhibition.As a kind of lipid that approaches most human body sebum, can combine together with mankind itself's sebum film, at skin surface, form the natural barrier of one deck.It can suppress the peroxidating of skin lipid, can effectively infiltrate through skin, and promotes the propagation of skin base cell, and to delay skin aging, improving and eliminating chloasma all has obvious physiologic effect.Having the different physiological roles such as the interior superoxide dismutase activity of the body of raising, enhancing human body immunity ability, defying age, resisting fatigue, antitumor, is a kind of avirulent marine bioactivity material with the effect of preventing and curing diseases.Squalane also can make skin pore open, and promotes blood microcirculation, promotes the metabolism of cell, helps to repair damaged cell.Give the fabulous brightness of product and combing sensation, moisten and non-greasy.
Nicotiamide is also vitamin B
3, be the stable small molecular weight material of a kind of water solublity, can pass rapidly horny layer.It can improve the barrier action of skin, reduces transepidermal water loss rate; Suppress melanosome and transfer to keratinocyte from pigment cell, suppress melanocyte transport way, reduce face red spot, pigmentation; Stop nonenzymatic glycosylation of protein, improve the situation of face jaundice; The content that promotes mucopolysaccharide in dermal collagen and adjusting corium, reduces wrinkle; By reducing the secretion of oils and fats, reduce pore, make skin texture moist.Its freckle removing and whitening effect shows as: accelerate metabolism, promote to come off containing melanic horn cell; Act on the melanin having produced, reduce it and shift to cells of superficial layer; Promote the synthetic of epidermal area protein, improve skin quality.
Vitamin C can be restrained chromoplast deposition, not only can effectively prevent black speck and freckle, unnecessary pigment can also be excreted, and thoroughly improves the low and deep colour of skin, makes skin again become pale bright.Vitamin C has the oily effect of control, gives in time skin vitimin supplement C, can improve greasy, the dim Huang of skin, the dry also general red blood streak of two cheeks, and the colour of skin is inhomogeneous etc.Or natural antioxidant, can effectively control intracellular oxidation reaction, help the quick toxin expelling of human body, allow the skin vigor of remaining youthful forever.
Sodium alginate, as thickening agent and stabilizing agent, improves the stability of emulsion, keeps the good stable form of emulsion, reduces liquid and oozes out or shrink.It can improve homogeneity and the water holding effect of emulsion inside, plays skin moisture-keeping function.
Carbomer has efficient thickening effect, can produce as clear as crystal water or alcohol-water gel rubber system, is applicable to various cosmetics.Carbomer after neutralization (conventional amount used 0.25-0.5%) under very low consumption just can produce efficient thickening power, thereby prepares the very preparation of wide range of viscosities and various flows degeneration.
Poloxamer is the novel macromolecule non-ionic surface active agent of a class, and it is soluble in water, thus in the water of emulsion as emulsifying agent; Self emulsifying mixed emulsifier is soluble in lipid and is insoluble in water, thus in the oil phase of emulsion as emulsifying agent; Two kinds of emulsifying agents are composite by a certain percentage in biphase at oil, water respectively, form the better emulsifying agent of emulsifying effectiveness.
Glycerol has another name called " glycerol ", has water absorption, puts on the skin on skin and can form thin film, has isolated air and prevents the effect that moisture evaporates, and can also absorb airborne moisture.It can make skin keep soft, and high resilience, is not subject to the infringements such as dust, weather and is dried, play prevent skin frostbite effect.In various cosmetics, through conventional glycerol, do wetting agent and softening agent.
The methyl hydroxybenzoate of low concentration just has efficient sterilization and anticorrosion effect, prevents and treats emulsion putrid and deteriorated.The disodiumedetate of low concentration is good metal-chelator, can, in conjunction with metal ion free in emulsion, improve emulsion quality.
Its anti crease and anti senile prepared old effect shows as: the multivitamin being rich in Caulis et Folium Brassicae capitatae and pea seedlings extract, and vitamin C can be brought into play anti-oxidation function, thereby strengthens the skin stress ability of environment to external world, strengthens skin immunization power; Vitamin A can make skin keep elasticity, and can make skin have anti-damage ability, can delay skin aging, there is stronger beautification function; Oleum Vitis viniferae and Fructus Tritici aestivi have pair skin to have good affinity, are easy to absorb, and make skin moisturizing and by gloss.A large amount of oligomeric proanthocyanidin OPC in Semen Vitis viniferae extract, can protecting human bodies skin, avoids free radical invasion and attack, and this function makes skin increase elasticity.Semen Vitis viniferae extract has astriction, tightens up skin, prevents occurring ahead of time of wrinkle of skin.It or natural sunlight overcover, can shielding of ultraviolet infringement skin, can also repair injured collagen protein and elastic fiber.Active skull cap components moistness in Semen Tritici aestivi germ oil is strong, can desalinate microgroove, striae gravidarum, cicatrix, increases skin wetting power, to dry, hydropenia, aging, wrinkle skin is extremely helpful.
Its freckle removing and whitening effect shows as: nicotiamide can pass rapidly horny layer, suppresses melanosome and transfers to keratinocyte from pigment cell, suppresses melanocyte transport way, reduces face red spot, pigmentation; Stop nonenzymatic glycosylation of protein, improve the situation of face jaundice; The content that promotes mucopolysaccharide in dermal collagen and adjusting corium, reduces wrinkle; By reducing the secretion of oils and fats, reduce pore and make skin texture moist.Squalane can effectively infiltrate through skin, and promotes the propagation of skin base cell, and to delay skin aging, improving and eliminating chloasma all has obvious physiologic effect.Vitamin C can be restrained chromoplast deposition, not only can effectively prevent black speck and freckle, unnecessary pigment can also be excreted, and thoroughly improves the low and deep colour of skin, makes skin again become pale bright.
Its correcting and skin moisturizing and rejuvenating effect shows as: pea seedlings can be dispelled the too much oils and fats of skin secretion, improves the water oil balance of skin, is skin refreshing and non-greasy.Vitamin C also has the oily effect of control, gives in time skin vitimin supplement C, can improve greasy, the dim Huang of skin, the dry also general red blood streak of two cheeks, and the colour of skin is inhomogeneous etc.Nicotiamide can be brought into play skin barrier effect, keeps epidermis moisture full.Squalane, as a kind of lipid that approaches most human body sebum, can effectively infiltrate through skin, promotes blood microcirculation, promotes the metabolism of cell, helps to repair damaged cell.Sodium alginate has hydrophilic, can make skin lock lastingly water moisturizing.
Emulsion abnormal smells from the patient prepared by the present invention is fresh and clean, and homogeneous exquisiteness is applied to the comfortable slim and graceful easily absorption of skin refreshing.Bring into play the skin that compacts, repair the effect of microgroove, whitening Glycerin when dispelling pigmented spots, the moisturizing of lock water, makes the tender light of skin beauty water, is a kind of splendid natural crease-resistant skin care emulsion.With prior art, compare, emulsion of the present invention has been added multiple crude vegetable extract and various plants essential oils, has the microgroove that compacts, promotes newborn, the effective crease-resistant effect of skin.Other active substances in emulsion, to dispelling pigmentation, improve skin dimness and have good effect; Glycerin, makes skin children tender fine and smooth.And the natural fresh vegetable juice of institute's adding ingredient for directly squeezing, abnormal smells from the patient is pure and fresh, without adding any essence again.
The specific embodiment
Below in conjunction with specific embodiments, this invention is described further.
The Oleum Vitis viniferae that the present invention is used and Semen Tritici aestivi germ oil are commercially available.
Embodiment 1
The preparation of 1.1 Sucus Caulis et Folium Brassicae capitataes
Choose fresh Caulis et Folium Brassicae capitatae, with distilled water, clean, be cut into little, with gradation after distilled water immersion 0.4h, squeeze the juice, get Caulis et Folium Brassicae capitatae in right amount at every turn and add 4 times of amount distilled water to squeeze, merge the Sucus Caulis et Folium Brassicae capitatae that gradation is squeezed, with clean double gauze filter 23, to remove the residue in juice, the clear filtrate after filtering is merged, volume is concentrated into 3 times of g/ml of Caulis et Folium Brassicae capitatae weight, more obtains the required Sucus Caulis et Folium Brassicae capitatae of preparation with the inferior residue of separating out in concentrated juice of removing of double gauze filter 23.
The preparation of 1.2 pea seedlings juice
Choose fresh tender leaf pea seedlings, with distilled water, clean, be cut into segment, with gradation after distilled water immersion 0.5h, squeeze the juice, get pea seedlings appropriate and add 4 times of amount distilled water to squeeze at every turn, merge the pea seedlings juice that gradation is squeezed, with clean double gauze filter 23, to remove the residue in juice, clear filtrate after filtering is merged, volume is concentrated into 3 times of g/ml of pea seedlings weight, more obtains the required pea seedlings juice of preparation with the inferior residue of separating out in concentrated juice of removing of double gauze filter 23.
The preparation of 1.3 sodium alginate gel
Take sodium alginate 1.5g, add distilled water 50ml, first it is heated to 80 ℃ with water-bath, heat while stirring, sodium alginate is dissolved completely, after mix homogeneously, standing its abundant swelling that allows, obtains the transparent gel of stable homogeneous.
The preparation of 1.4 carbomer gels
Take Acritamer 940 1.0g, add distilled water 100ml, heating in water bath to 80 ℃, limit heating edge stirs rapidly, and standing allowing after its abundant swelling, with the neutralization of 1.0g triethanolamine, slow one after another drop of adding, limit adds surveys pH value while stirring, when PH=7, obtains the clear gel that viscosity and denseness are suitable.
The preparation of 1.5 emulsions
A) get respectively Oleum Vitis viniferae 1.0ml, Semen Tritici aestivi germ oil 1.0ml, synthetic squalane 0.5ml, in small beaker, three is stirred, add again self emulsifying mixed emulsifier AC-4021.5g, heating in water bath in 80 ℃, heat while stirring it is dissolved completely, obtain the oil phase in O/W type emulsion;
B) take poloxamer 0.5g, add 15ml distilled water, heating in water bath in 80 ℃, heats while stirring, and it is dissolved completely, obtains the water in O/W type emulsion;
C) oil phase and water heat after 15min in 80 ℃ of water-baths simultaneously, and oil phase is slowly joined to water and constantly stirs in the same direction along walls of beaker with thread shape, and speed is unsuitable too fast.After 20min, emulsifying completes and obtains O/W type emulsion;
D) Sucus Caulis et Folium Brassicae capitatae and each 1.0ml of pea seedlings juice, mix, and the standing room temperature that is cooled to of above-mentioned emulsion, adds each 0.2g of vitamin C and nicotiamide, then add Sucus Caulis et Folium Brassicae capitatae and the pea seedlings juice mixing;
E) take 10% disodiumedetate 0.1g, 20% methyl hydroxybenzoate alcoholic solution 0.01mg, measure glycerol 3.0ml, mix homogeneously, adds in above-mentioned emulsion, constantly stirs and makes mix homogeneously;
F) in the emulsion making, add the above-mentioned carbomer gel having prepared, sodium alginate gel, constantly stir, make the emulsion that viscosity and denseness are suitable.
Embodiment 2
The preparation of 2.1 Sucus Caulis et Folium Brassicae capitataes
Choose fresh Caulis et Folium Brassicae capitatae, with distilled water, clean, be cut into little, with gradation after distilled water immersion 0.4h, squeeze the juice, get Caulis et Folium Brassicae capitatae appropriate and add at every turn, 6 times of amount distilled water squeeze, and merge the Sucus Caulis et Folium Brassicae capitatae that gradation is squeezed, and with clean double gauze, filter 5 times, to remove the residue in juice, clear filtrate after filtering is merged, and volume is concentrated into 5 times of g/ml of Caulis et Folium Brassicae capitatae weight, then filters and remove the residue of separating out in concentrated juice for 5 times and obtain the required Sucus Caulis et Folium Brassicae capitatae of preparation with double gauze.
The preparation of 2.2 pea seedlings juice
Choose fresh tender leaf pea seedlings, with distilled water, clean, be cut into segment, with gradation after distilled water immersion 0.5h, squeeze the juice, get pea seedlings appropriate and add 6 times of amount distilled water to squeeze at every turn, merge the pea seedlings juice that gradation is squeezed, with clean double gauze, filter 5 times, to remove the residue in juice, clear filtrate after filtering is merged, volume is concentrated into 5 times of g/ml of pea seedlings weight, then filters and to remove the residue of separating out in concentrated juice for 5 times and obtain the required pea seedlings juice of preparation with double gauze.
The preparation of 2.3 sodium alginate gel
Take sodium alginate 4.5g, add distilled water 60ml, first it is heated to 75 ℃ with water-bath, heat while stirring, sodium alginate is dissolved completely, after mix homogeneously, standing its abundant swelling that allows, beaker bottom, without in bulk sodium alginate, obtains the transparent gel of stable homogeneous.
The preparation of 2.4 carbomer gels
Take Acritamer 940 2.0g, add distilled water 100ml, heating in water bath to 75 ℃, limit heating edge stirs rapidly, standing allowing after its abundant swelling, with the neutralization of 2.0g triethanolamine, slowly one after another drop of adding, limit adds surveys pH value while stirring.When PH=7, obtain the clear gel that viscosity and denseness are suitable.
The preparation of 2.5 emulsions
A) get respectively Oleum Vitis viniferae 5.0ml, Semen Tritici aestivi germ oil 5.0ml, synthetic squalane 3.0ml, in small beaker, three is stirred, add again self emulsifying mixed emulsifier (AC-402) 3g, heating in water bath in 75 ℃, heat while stirring it is dissolved completely, obtain the oil phase in O/W type emulsion;
B) take poloxamer 3.0g, add 30ml distilled water, heating in water bath in 70-80 ℃, heats while stirring, and it is dissolved completely, obtains the water in O/W type emulsion;
C) oil phase and water heat after 20min in 75 ℃ of water-baths simultaneously, and oil phase is slowly joined to water and constantly stirs in the same direction along walls of beaker with thread shape, and speed is unsuitable too fast.After about 30min, emulsifying completes and obtains O/W type emulsion;
D) Sucus Caulis et Folium Brassicae capitatae and each 5.0ml of pea seedlings juice mix, and the standing room temperature that is cooled to of above-mentioned emulsion adds each 0.5g of vitamin C and nicotiamide, adds Sucus Caulis et Folium Brassicae capitatae and the pea seedlings juice mixing again;
E) take 10% disodium ethylene diamine tetra-acetic acid solution 0.2g, 20% methyl hydroxybenzoate alcoholic solution 0.02mg, measure glycerol 5.0ml, mix homogeneously, adds in above-mentioned emulsion, constantly stirs and makes mix homogeneously;
F) in the emulsion making, add the above-mentioned carbomer gel having prepared and sodium alginate gel, constantly stir, make the emulsion that viscosity and denseness are suitable.
Embodiment 3
The physical and chemical index of embodiment 1,2 is as follows:
3.1 character
This product is that abnormal smells from the patient is fresh and clean, homogeneous exquisiteness, and viscosity is suitable, the light green emulsion that stretchability is good and salubrious.
3.2PH value checks
With Glass rod, dip a small amount of emulsion in moistening PH reagent paper, with standard color comparison card contrast, PH is 6-7.
3.3 caloric test
Emulsion is packaged in transparent dressing product bottle, in the refrigerator cold-storages of 4 ℃, within one month, observes without lamination.24h in the calorstat of 55 ℃, emulsion is without layering, the phenomenon such as spoiled.
3.4 centrifugal test
Emulsion is packaged in to 3000r/min in tool plug test tube, and centrifugal 20min, without breakdown of emulsion lamination.
3.5 room temperatures are placed test
Above-mentioned made emulsion is placed in to bottle for cosmetics, the standing investigation of room temperature 6 months, without lamination, use aftersensation is unchanged, abnormal smells from the patient is unchanged.
3.6 irritation tests, anaphylaxis experiment
White mice back cuts off hair, smears the emulsion of above-mentioned preparation in cutting plucked position, and is not coated with position and compares, and result does not have zest and anaphylaxis.
The emulsion of getting above-mentioned preparation is applied in volunteer (25-65 year, 60 people) gesture and facial expression, observes after spending 30 minutes, all do not occur rubescent, dermexanthesis, foaming phenomenon.
Superoxide dismutase (SOD), glutathion peroxidase (GPX), malonaldehyde (MDA) horizontal detection in 3.7 mouse skin tissues
The significance of SOD effect is to remove H
2o
2with predecessor's superoxide ion of OH, thereby Cell protection is not subject to the damage of toxicity oxygen-derived free radicals.By detecting its active reaction cell oxidation resistance; GPX can become GSSG by catalysis GSH, make poisonous peroxide be reduced into nontoxic hydroxy compounds, thereby the structure of Cell protection film and function is not subject to interference and the infringement of peroxide; MDA is a kind of aldehyde material generating in the lipid peroxidation process that causes of free radical, by detecting its content, can reflect the snperoxiaized degree of cytolipin.
20 mices are divided into two groups at random, each 10 of experimental group, matched groups.The processing of matched group: mouse back left side hair is rejected, raise after two months, get left part skin histology and be prepared into 10% homogenate, 2500r/min with 0.86% cold saline machinery homogenate, after 4 ℃ of centrifugal 10min, get supernatant and record SOD, GPX and MDA level wherein; The processing of experimental group: mouse back left side hair is rejected, emulsion is evenly spread upon on skin of unhairing, smear continuously after two months for twice every day sooner or later, with matched group same treatment comparative result.Testing result sees the following form 1.
Each index testing result of table 1
| ? | SOD | GPX | MDA |
| Experimental group | +++ | +++ | -- |
| Matched group | -- | -- | ++ |
+ the positive: the activity that represents enzyme raises or content increase;
-feminine gender: represent that the activity decreased of enzyme or content reduce.
Experiment shows, this emulsion significantly improves SOD, the GPX level of Skin Cell and reduces MDA content, and its obvious anti oxidative damage illustrates that this emulsion has good crease-resistant effect.
3.8 anti-wrinkle effect experiments
By experiment on probation, evaluate the anti-wrinkle effect of above-mentioned made emulsion.Utilize emulsion and the commercially available crease-resistant emulsion that preparation technology of the present invention produces to carry out contrast experiment.Choose 160 of 25-55 year women, according to the depth degree of facial microgroove, they are divided into arbitrarily to 4 groups, every group of 40 people, every day, each twice use emulsion was coated with face sooner or later, experimental group 1 is young group (25-35 year), experimental group 2 is young group (25-35 year), and experimental group 3 is middle aged group (35-45 year), and experimental group 4 is old group (45-55 year), matched group is smeared commercially available moisture-keeping crease-shedding emulsion, uses continuously two months.The improvement situation of skin of detecting by an unaided eye is evaluated the crease-resistant skin care effect of above-mentioned prepared emulsion, and result is as following table 2.
Table 2 result of use
| Experimental group | Efficiently individual quantity | Efficiently individual quantity slightly | Invalid number |
| 1 | 35 | 4 | 1 |
| 2 | 33 | 5 | 2 |
| 3 | 27 | 8 | 5 |
| 4 | 23 | 10 | 7 |
3.9 these emulsion resultant effects are evaluated
Below utilize the effect of feeling to evaluate the emulsion producing on probation.Adopt public-opinion poll point system, the women who randomly draws 80 25-55 year age bracket is object on probation, according to different skin quality groupings, investigates, and puts the emulsion of above-mentioned preparation on the skin arm.Use twice every day, two months service time.Every result of use total points is 5 minutes: five are divided into best result, represents fine, very satisfied; 4 are divided into better; 3 are divided into and can accept; 3 minutes is bad below, can not accept.It is below every average.Experimental result is in Table 3
Table 3 comprehensive evaluation result
In sum, the emulsion that the present invention develops all has good moisturizing, moist, anti-wrinkle effect to various skin quality, comfortable salubrious after using, make skin-tightening water tender, in addition the effect of necessarily dispelling in addition pigmented spots, whitening nourishing is a kind of crease-resistant emulsion that is particularly suitable for younger and female middle-aged skin nursing and reparation.
Claims (4)
1. containing a crease-resistant skin care emulsion for natural component extract, it is characterized in that, in the crease-resistant skin care emulsion of 150g, contain following material:
2. crease-resistant skin care emulsion according to claim 1, is characterized in that, described Sucus Caulis et Folium Brassicae capitatae is prepared by the following method:
Choose fresh Caulis et Folium Brassicae capitatae, with distilled water, clean, be cut into little, with gradation after distilled water immersion 0.3-0.5h, squeeze the juice, get Caulis et Folium Brassicae capitatae appropriate and add 3-6 doubly to measure distilled water to squeeze at every turn, merge the Sucus Caulis et Folium Brassicae capitatae that gradation is squeezed, with clean double gauze filter 23-5 time, to remove the residue in juice, clear filtrate after filtering is merged, and volume is concentrated into 3-5 times of g/ml of Caulis et Folium Brassicae capitatae weight, then uses double gauze filter 23-5 time, remove the residue of separating out in concentrated juice, make Sucus Caulis et Folium Brassicae capitatae standby.
3. crease-resistant skin care emulsion according to claim 1, is characterized in that, described pea seedlings juice is prepared by the following method:
Choose fresh pea seedlings, with distilled water, clean, be cut into segment, with after distilled water immersion 0.3-0.5h, gradation is squeezed the juice, get pea seedlings appropriate and add 2-4 doubly to measure distilled water to squeeze at every turn, merge the pea seedlings juice that gradation is squeezed, with clean double gauze filter 23-5 time, to remove the residue in juice, clear filtrate after filtering is merged, volume is concentrated into 2-4 times of g/ml of pea seedlings weight, then uses double gauze filter 23-5 time, removes the residue of separating out in concentrated juice, make pea seedlings juice, standby.
4. a preparation method for the crease-resistant skin care emulsion containing natural component extract claimed in claim 1, is characterized in that, described preparation method comprises the following steps:
A) take sodium alginate 1.5-4.5g, add distilled water 30-70ml, heating in water bath, to 60-80 ℃, heats while stirring, and after mix homogeneously, standing its abundant swelling that allows, is clear gel, standby;
B) take carbomer 1.0-2.0g, add distilled water 60-100ml, heating in water bath is to 60-80 ℃, and limit heating edge stirs rapidly, standing allowing after its abundant swelling, dropwise adds the neutralization of 1.0-2.0g triethanolamine, and limit adds surveys pH value while stirring, when PH=7, be clear gel, standby;
C) get respectively Oleum Vitis viniferae 1.0-5.0ml, Semen Tritici aestivi germ oil 1.0-5.0ml, synthetic squalane 0.5-3.0ml, three is uniformly mixed, add again self emulsifying mixed emulsifier 0.5-7.5g, heating in water bath in 70-80 ℃, heat while stirring and make its mix homogeneously, obtain the oil phase of O/W type emulsion;
D) take poloxamer 0.5-5.0g, add 15-30ml distilled water, heating in water bath in 70-80 ℃, heats while stirring, and it is dissolved completely, obtains the water in O/W type emulsion;
E) measure respectively Sucus Caulis et Folium Brassicae capitatae and the pea seedlings juice 1.0-5.0ml of preparation, stirred, as the main composition of emulsion;
F) take respectively 10% disodium ethylene diamine tetra-acetic acid solution 0.01-0.5g, 20% methyl hydroxybenzoate alcoholic solution 0.01-0.5mg, add glycerol 1.0-8.0ml, stir and make its mix homogeneously, as the antiseptic in emulsion and wetting agent;
G) in 70-80 ℃ of water-bath, Deng oil phase, when water reaches uniform temp, by step c) oil phase prepared is thread shape and slowly joins steps d along walls of beaker) in the water prepared, limit heating edge at the uniform velocity stirs along same side, after 15-30min, emulsifying completes, obtain O/W type emulsion, until emulsion, stir and be cooled to after room temperature, add each 0.1-0.5g of vitamin C and nicotiamide, step e) Sucus Caulis et Folium Brassicae capitatae mixing of preparing and pea seedlings juice, step f) antiseptic of preparing and wetting agent, the sodium alginate gel that step a) is prepared and step b) carbomer gel prepared stirs.
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| CN106309166A (en) * | 2016-08-30 | 2017-01-11 | 闫涛 | Moisturizing skin care lotion containing grape seed oil and preparation method of moisturizing skin care lotion |
| CN111449995A (en) * | 2020-05-14 | 2020-07-28 | 姜惠琴 | Water-in-oil type whitening skin care emulsion and preparation method thereof |
| CN114984070A (en) * | 2022-07-21 | 2022-09-02 | 广州盛欣化妆品有限公司 | Skin-tendering emulsion |
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| CN114984070A (en) * | 2022-07-21 | 2022-09-02 | 广州盛欣化妆品有限公司 | Skin-tendering emulsion |
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