CN111939096B - Moisture-preserving skin-care emulsion containing tetrahydropyrimidine and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of daily cosmetics, and particularly relates to tetrahydropyrimidine-containing moisturizing skin care cream which is prepared from the following raw materials in percentage by weight: 0.5-2.0% of tetrahydropyrimidine, 1.0-3.0% of rape flower honey, 2% -8% of cetearyl glucoside, 0.5-5.0% of glyceryl oleate citrate, 0.5-2.0% of witch hazel extract, 0.5-1.5% of bisabolol, 2-4% of shea butter, 1-3% of nicotinamide, 3-8% of glycerol, 0.1-0.3% of phenoxyethanol and a proper amount of deionized water. The pure natural skin care lotion prepared by the formula has the advantages that the skin moisture rate is improved by at least 10%, meanwhile, the harm of chemical components to human bodies is avoided, and the use safety is improved.

Description

Moisture-preserving skin-care emulsion containing tetrahydropyrimidine and preparation method thereof

Technical Field

The invention belongs to the technical field of daily cosmetics, and particularly relates to a moisturizing skin care emulsion containing tetrahydropyrimidine and a preparation method thereof.

Background

Whitening, moisturizing and anti-aging are always female demands on beauty products and are also permanent subjects in the field of skin care product research. Along with the continuous progress of social economy, the increasing abundance of material life and the gradual enhancement of health consciousness, cosmetics rich in natural functional components are more and more popular with people. At present, skin care products on the market are various in types, different in performance and single in effect orientation, and the requirement of multiple effects of a single product expected by most consumers is difficult to meet; secondly, due to abuse of chemical components in the cosmetics, most of the functional components are chemical synthetic substances, such as hydroquinone, salicylic acid and other whitening components, and the cosmetic can cause secondary damage to the skin after long-term use and is easy to cause anaphylactic reaction; meanwhile, because various problems of mixing, corrosion resistance, oxidation resistance and the like of various natural components are difficult to overcome, and factors such as production cost reduction and the like are solved, most domestic and foreign products in the market still adopt basic materials of the chemical industry era until now, and some natural components are added to form natural cosmetics. Various pure natural skin care products appear on the market, for example, Chinese patent with publication number of CN103301050A discloses an external pure natural skin care product and a preparation method thereof, wherein the product takes the linseed extract prepared from pure natural linseed as a main material and has the functions of caring and moistening skin; for another example, the chinese patent publication No. CN107184519A discloses a skin-care product made of natural Chinese herbs and its application method, wherein the product is made of natural fruits, vegetables and food Chinese herbs, and has certain functions of moistening skin, removing wrinkles, diminishing inflammation, whitening skin, removing speckles, expelling toxin and caring skin, and has good skin-care effect and safe use. For another example, the chinese patent publication No. CN106137939A discloses a pure natural skin care lotion, which is prepared by mixing and decocting a plurality of traditional Chinese medicines, is pure natural without side effects, can gradually whiten and whiten the skin after long-term use, and can gradually lighten the chloasma, freckles and the like of the skin after continuous use for more than two months. Although the skin care health products developed by various natural raw materials adopt pure natural substances or pure natural substances as main components, the formula is unstable and cannot be stored for a long time due to the fact that no emulsifier is used, or the used emulsifier is not pure natural substances and has certain damage to the skin after long-term use; secondly, the skin care product cannot be stored for a long time because a part of the skin care product is not used with preservatives or the used preservatives are chemical substances, so that the skin can be damaged for the second time, and certain safety problems exist.

Disclosure of Invention

Aiming at the problems, the invention provides the moisture-keeping skin care cream containing the tetrahydropyrimidine, which is prepared from pure natural raw materials, mainly relates to the use of components such as an emulsifier, a humectant, an antioxidant, a preservative and the like, avoids the preparation of excessive chemical preparations, and effectively reduces the secondary damage to the skin in the long-term use process.

Meanwhile, the invention also provides a preparation method of the moisturizing and skin-care emulsion, which is prepared by mixing and emulsifying the water-phase raw material and the oil-phase raw material and then adding other auxiliary materials.

In order to achieve the purpose, the invention adopts the technical scheme that:

the moisture-preserving skin care cream containing tetrahydropyrimidine comprises the following raw materials in percentage by weight: 0.5-2.0% of tetrahydropyrimidine, 1.0-3.0% of rape flower honey, 2% -8% of cetearyl glucoside, 0.5-5.0% of glyceryl oleate citrate, 0.5-2.0% of witch hazel extract, 0.5-1.5% of bisabolol, 2-4% of shea butter, 1-3% of nicotinamide, 3-8% of glycerol, 0.1-0.3% of phenoxyethanol and a proper amount of deionized water.

Further, the moisture-preserving skin care cream containing tetrahydropyrimidine comprises the following raw materials in percentage by weight: 1.5% of tetrahydropyrimidine, 2.4% of rape flower honey and 7.6% of cetearyl glucoside; 0.85% of glyceryl oleate citrate, 1.04% of witch hazel extract, 0.25% of bisabolol, 2.69% of shea butter, 2.75% of nicotinamide, 4.98% of glycerol, 0.26% of phenoxyethanol and a proper amount of deionized water.

Further, the witch hazel extract is prepared by the following method: cleaning and crushing witch hazel, weighing 10-15 g of witch hazel, adding 200mL of water, soaking for 12h, heating in a water bath, performing reflux extraction at 80-90 ℃, performing reflux extraction for 2h each time, performing suction filtration while hot, combining filtrates, adding 95% ethanol into the filtrate for ethanol precipitation, standing for 24h, performing filtration to obtain a supernatant, concentrating and recovering ethanol, and fixing the volume for later use.

Meanwhile, the invention provides a preparation method of the moisturizing and skin-care emulsion containing tetrahydropyrimidine, which comprises the following steps:

(1) preparation of the aqueous phase: weighing deionized water, glycerol and witch hazel extract according to the weight parts, placing the deionized water, the glycerol and the witch hazel extract in a super constant temperature water bath tank at 85-90 ℃, and stirring until the deionized water, the glycerol and the witch hazel extract are dissolved;

(2) preparation of oil phase: weighing cetearyl glucoside, glyceryl oleate citrate and shea butter according to the weight parts, placing in a constant temperature water bath box at 90 ℃, and stirring until the cetearyl glucoside, the glyceryl oleate citrate and the shea butter are dissolved;

(3) mixing: slowly adding the oil phase into the water phase along the glass rod and continuously stirring along the same direction until the oil phase is uniformly mixed;

(4) when the temperature is lower than 45 ℃, adding tetrahydropyrimidine, rape flower honey, bisabolol, nicotinamide and phenoxyethanol, and emulsifying for 20-30 min in a high-speed homogenizer at the rotating speed of 10000r/min until the temperature is lower than 38 ℃ to obtain the emulsion.

The tetrahydropyrimidine is a compatible solute which is synthesized in halophilic or halotolerant bacteria cells and can resist external high-salt stress, can be used as a cell protective agent and a stabilizing agent to resist various harmful environmental influences, for example, the tetrahydropyrimidine can be used as a water binding agent to help to recombine skin cell membranes, protect the skin from being damaged by ultraviolet rays, moisten the skin and inhibit the generation of melanin, thereby delaying the premature aging of the skin and the like. In addition to skin protection, it can be used for treating atopic dermatitis, Alzheimer's disease, and inhibiting HIV replication and liver cirrhosis. Ectoine has important application in the fields of enzyme preparations, genetic engineering, medical treatment, cosmetics and the like as an important secondary metabolite of microorganisms, and becomes a hotspot of research and development of biological preparations and fine chemical engineering.

The rape flower honey is rich in plant polyphenol (such as flavonoid and phenolic acid compounds), and is derived from honeydew, pollen and the like in plants collected by bees. The polyphenol substance has a phenolic hydroxyl structure, and can terminate the chain reaction of free radicals by generating a more stable semiquinone free radical, thereby having antioxidant activity. Meanwhile, the honey also has the biological activity functions of resisting bacteria and radiation, reducing blood fat, improving the immunity of the organism and the like. The green sea rape flower honey is single flower honey derived from rape flower, and has light amber color, milky white crystal, or semi-crystalline state, high purity and delicate fragrance. Because of high Qinghai altitude, fresh air, little pollution, strong sunlight radiation, long illumination time and dry climate, the Qinghai rape flower honey has low water content and the special quality is superior to various indexes of similar products in China. For example, green sea rape flower honey does not contain the carboxymethylfurfural component (5-hydroxymethyfurfurfural HMF) compared to other types of honey, is non-irritating to eyes, mucous membranes or skin, does not cause skin poisoning after being ingested, and has low or no heavy metals content which is much lower than other types of honey. Secondly, compared with other types of honey, the green sea rape flower honey is rich in higher content of honey protein (amino acid), vitamins (table 1), trace elements and the like, and has important effects on metabolism, growth and development, skin care and nutrition of body cells. In addition, the green sea rape flower honey is rich in vitamin A, vitamin E, vitamin C, unsaturated fatty acid and vitamin B2, and plays important roles of metabolism regulation and antioxidation. For example, vitamin E hydrolysate is tocopherol, one of the most important antioxidants, preventing free radicals from harming the human body; vitamin C has antioxidant effect and can protect other antioxidants such as vitamin A and vitamin E; vitamin A has effects of regulating metabolism of epidermis and stratum corneum, resisting aging, and removing wrinkle; vitamin B2 has effects in promoting skin, nail and hair growth, and resisting oxidation.

The invention has the following advantages:

the invention selects the cetearyl glucoside and the glyceryl oleate citrate as two natural emulsifiers of natural plant sources, has high purity, no adverse impurities, safety, excellent skin feel after use, quick absorption, light weight and moisture, and is particularly suitable for sensitive skin. Ectoine and green sea rape flower honey which is rich in amino acid, vitamins (B1, B2, VC, VE, VA, D3, B6, nicotinic acid, folic acid and inositol) and trace elements are used as main effective components, and tetrahydropyrimidine Ectoine is a natural protective molecule for maintaining water, has the effects of protecting cells and resisting inflammation, and can moisten the skin, prevent the skin from being damaged by ultraviolet rays, inhibit the generation of melanin, further delay the premature aging of the skin and the like. Secondly, the green sea rape flower honey rich in amino acid, multiple vitamins and trace elements is supplemented, so that the moisturizing effect is better, and the trend of returning cosmetics to nature is met; meanwhile, the pure natural skin care lotion is prepared by taking bisabolol and witch hazel extract which have the functions of resisting inflammation, spasm, broad-spectrum bacteria, oxidation and the like as main preservatives, so that the harm of chemical components to human bodies is avoided, and the use safety is improved. The prepared pure natural skin care lotion has the advantages that the skin moisture rate is improved by at least 10%, meanwhile, the harm of chemical components to human bodies is avoided, and the use safety is improved.

Detailed Description

In order to make the technical solutions of the present invention better understood by those skilled in the art, the present invention is further illustrated below with reference to examples.

The invention provides a tetrahydropyrimidine-containing moisturizing skin care lotion which is prepared from the following raw materials in percentage by weight: 0.5-2.0% of tetrahydropyrimidine, 1.0-3.0% of rape flower honey, 2% -8% of cetearyl glucoside, 0.5-5.0% of glyceryl oleate citrate, 0.5-2.0% of witch hazel extract, 0.5-1.5% of bisabolol, 2-4% of shea butter, 1-3% of nicotinamide, 3-8% of glycerol, 0.1-0.3% of phenoxyethanol and a proper amount of deionized water.

Example 1

The embodiment provides a moisturizing skin care lotion containing tetrahydropyrimidine, which consists of the following raw materials in percentage by weight: 1.50% of tetrahydropyrimidine, 2.40% of rape flower honey and 7.60% of cetearyl glucoside; 0.85% of glyceryl oleate citrate, 1.04% of witch hazel extract, 0.25% of bisabolol, 2.69% of shea butter, 2.75% of nicotinamide, 4.98% of glycerol, 0.26% of phenoxyethanol and 75.68% of deionized water.

Example 2

The embodiment provides a moisturizing skin care lotion containing tetrahydropyrimidine, which consists of the following raw materials in percentage by weight: 1.00 percent of tetrahydropyrimidine, 2.30 percent of rape flower honey and 7.54 percent of cetearyl glucoside; 0.85% of glyceryl oleate citrate, 1.04% of witch hazel extract, 0.20% of bisabolol, 2.69% of shea butter, 2.53% of nicotinamide, 5.20% of glycerol, 0.15% of phenoxyethanol and 76.50% of deionized water.

Example 3

The embodiment provides a moisturizing skin care lotion containing tetrahydropyrimidine, which consists of the following raw materials in percentage by weight: 1.5% of tetrahydropyrimidine, 2.3% of rape flower honey and 7.55% of cetearyl glucoside; 0.85% of glyceryl oleate citrate, 1.04% of witch hazel extract, 0.18% of bisabolol, 2.69% of shea butter, 3.86% of nicotinamide, 4.98% of glycerol, 0.2% of phenoxyethanol and 74.83% of deionized water.

Example 4

The embodiment provides a moisturizing skin care lotion containing tetrahydropyrimidine, which consists of the following raw materials in percentage by weight: tetrahydropyrimidine 0.5%, rape flower honey 2.4%, cetearyl glucoside 7.55%; 0.85% of glyceryl oleate citrate, 1.04% of witch hazel extract, 0.18% of bisabolol, 2.69% of shea butter, 4.25% of nicotinamide, 4.93% of glycerol, 0.11% of phenoxyethanol and 75.65% of deionized water.

The skin care emulsion takes witch hazel extract and bisabolol as main preservatives, and the components have antioxidant function and broad-spectrum antibacterial effect, and can effectively inhibit the growth of bacteria causing peculiar smell. Replaces the traditional preservative, can naturally preserve the quality of the moisturizing milk, avoids potential harm to human body caused by excessive addition of chemical preservative, and improves the use safety.

The skin care emulsion adopts natural plant source as emulsifier, has high purity, no adverse impurity, light weight, safety, rapid absorption, and excellent skin feeling, and is suitable for sensitive skin. Meets the safe use standard of cosmetics, especially the selection and compatibility of the emulsifier.

Example 5

The embodiment provides a preparation method of the moisturizing and skin-care milk, which comprises the following steps:

(1) preparation of the aqueous phase: weighing deionized water, glycerol and witch hazel extract according to the weight parts in the embodiments, placing the deionized water, the glycerol and the witch hazel extract in a super constant temperature water bath box at 85-90 ℃ and stirring until the deionized water, the glycerol and the witch hazel extract are dissolved;

(2) preparation of oil phase: weighing cetearyl glucoside, glyceryl oleate citrate and shea butter according to the weight parts, placing in a constant temperature water bath box at 90 ℃, and stirring until the cetearyl glucoside, the glyceryl oleate citrate and the shea butter are dissolved;

(3) mixing: slowly adding the oil phase into the water phase along the glass rod and continuously stirring along the same direction until the oil phase is uniformly mixed;

(4) when the temperature is lower than 45 deg.C, adding tetrahydropyrimidine, rape flower honey, bisabolol, nicotinamide, and phenoxyethanol, and emulsifying in a high-speed homogenizer at 10000r/min for 20 min.

The industrial mass and large-scale production is carried out, and the components are amplified, homogenized and aseptically packaged according to the proportion.

Example 6 tetrahydropyrimidine moisture retention assay

The Ectoine mass fraction gradients were set at 0%, 0.5%, 1%, 1.5% and 2%. Adopting glass slide and medical permeable adhesive tape, simulating cuticle and epidermis to make into 2cm × 3cm simulation device, smearing 0.5g sample, placing into 25 deg.C electrothermal blowing dry box, precisely weighing the mass M of the simulation device sample before placing₁And a post-placement mass M₂(4 times at 5 min/time intervals), and the moisture retention rate (M) was calculated₂/M₁X 100%) and the results are given in table 1 below.

TABLE 1 moisturizing ratio of different mass fractions of tetrahydropyrimidines moisturizing skin care creams

In the formula of the invention, the optimal proportion of Ectoine is 1.5%, the moisturizing effect is optimal, and the average value of the moisturizing rate is 99.6%. Analysis of the concentration and the moisturizing effect of Ectoine shows that the moisturizing effect is reduced to some extent when the Ectoine is lower than 1.5%, the moisturizing rate is 86.9-97.9%, and after the Ectoine is higher than 1.5%, the moisturizing effect is not obviously different, and the moisturizing rate is 97.9-99.6%.

Example 7 population testing

20 test volunteers with healthy skin, male and female proportion of 50%, age 22-25 years, were selected for the following tests (glucocorticoid, antihistamine medication was avoided 2 weeks before the test).

Spot test: folding several layers of gauze into a certain size (1 cm on each side of square, 1cm in diameter of circle), sticking the gauze with the test solution on the inner skin of forearm, covering with a plastic film, and fixing with bandage. The skin changes of the applied part were observed after 24h and 48h, respectively. The absence of any reaction at the test site is (-); the skin of the tested part has slight pruritus and redness (+); the skin of the tested part has simple erythema and pruritus (+/-); edema erythema and pimple (++) appear on the skin of the tested part; the skin at the test site showed marked erythema, papules and blisters (+++).

And (4) testing the moisture retention degree: the moisture values of the skin of the test person before, after and 30min and 1h after smearing are respectively tested, and the difference value of the moisture values is analyzed to evaluate whether the moisture retention of the product is excellent or not. The difference of the skin moisture values before and after the product is applied reflects the instant water replenishing capacity of the product, and the skin moisture value after 1h reflects the continuous shrinkage capacity of the product. Statistical analysis of variance showed that: the moisture content of the groups after being smeared is obviously increased compared with that before being smeared, the obvious difference p is less than 0.05, the moisture content of the groups after being smeared for 30min is not obviously changed compared with that of the groups after 1h, and the moisture retention rate of the experimental group is improved by more than 10% after 1h, which indicates that the skin care milk has good moisture retention effect.

TABLE 2 skin moisture test and Patch test results

TABLE 3 statistical analysis of skin moisture content

P <0.05, compared to pre-application group

In conclusion, the invention provides a stable system of emulsifier and the combination of functional components such as moisturizing, whitening, antioxidation and the like, and the emulsifier is mild in property and free of stimulation. After the skin care lotion is used by volunteer people, the moisture retention is improved by at least 10 percent, and the effect is good.

The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various changes may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are included in the protective scope of the present invention.

It should be noted that, in the foregoing embodiments, various specific technical features and steps described in the above embodiments can be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations of the features and steps are not described separately.

In addition, any combination of the various embodiments of the present invention is also possible, and the same should be considered as the disclosure of the present invention as long as it does not depart from the spirit of the present invention.

Claims (4)

1. The moisture-preserving skin care cream containing tetrahydropyrimidine is characterized in that: the composite material consists of the following raw materials in percentage by weight: 0.5-2.0% of tetrahydropyrimidine, 1.0-3.0% of rape flower honey, 2% -8% of cetearyl glucoside, 0.5-5.0% of glyceryl oleate citrate, 0.5-2.0% of witch hazel extract, 0.5-1.5% of bisabolol, 2-4% of shea butter, 1-3% of nicotinamide, 3-8% of glycerol, 0.1-0.3% of phenoxyethanol and a proper amount of deionized water.

2. The tetrahydropyrimidine-containing moisturizing skin care emulsion according to claim 1, wherein: the composite material consists of the following raw materials in percentage by weight: 1.5% of tetrahydropyrimidine, 2.4% of rape flower honey and 7.6% of cetearyl glucoside; 0.85% of glyceryl oleate citrate, 1.04% of witch hazel extract, 0.25% of bisabolol, 2.69% of shea butter, 2.75% of nicotinamide, 4.98% of glycerol, 0.26% of phenoxyethanol and a proper amount of deionized water.

3. The tetrahydropyrimidine-containing moisturizing skin care emulsion according to claim 1, wherein: the witch hazel extract is prepared by the following method: cleaning and crushing witch hazel, weighing 10-15 g of witch hazel, adding 200mL of water, soaking for 12h, heating in a water bath, performing reflux extraction at 80-90 ℃, performing reflux extraction for 2h each time, performing suction filtration while hot, combining filtrates, adding 95% ethanol into the filtrate for ethanol precipitation, standing for 24h, filtering to obtain a supernatant, concentrating and recovering ethanol, and fixing the volume.

4. A method for preparing moisturizing skin care cream containing tetrahydropyrimidine according to any one of claims 1 to 3, comprising the following steps:

(1) preparation of the aqueous phase: weighing deionized water, glycerol and witch hazel extract according to the weight parts, placing the deionized water, the glycerol and the witch hazel extract in a super constant temperature water bath tank at 85-90 ℃, and stirring until the deionized water, the glycerol and the witch hazel extract are dissolved;

(2) preparation of oil phase: weighing cetearyl glucoside, glyceryl oleate citrate and shea butter according to the weight parts, placing in a constant temperature water bath box at 90 ℃, and stirring until the cetearyl glucoside, the glyceryl oleate citrate and the shea butter are dissolved;

(3) mixing: slowly adding the oil phase into the water phase along the glass rod and continuously stirring along the same direction until the oil phase is uniformly mixed;

(4) when the temperature is lower than 45 ℃, adding tetrahydropyrimidine, rape flower honey, bisabolol, nicotinamide and phenoxyethanol, and emulsifying for 20-30 min in a high-speed homogenizer at the rotating speed of 10000r/min until the temperature is lower than 38 ℃ to obtain the emulsion.