CN110051614A - A kind of crease-resistant tender skin essence - Google Patents

A kind of crease-resistant tender skin essence Download PDF

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Publication number
CN110051614A
CN110051614A CN201910446650.1A CN201910446650A CN110051614A CN 110051614 A CN110051614 A CN 110051614A CN 201910446650 A CN201910446650 A CN 201910446650A CN 110051614 A CN110051614 A CN 110051614A
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parts
skin
essence
weight
crease
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金龙
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Bader's (shanghai) Polytron Technologies Inc
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Bader's (shanghai) Polytron Technologies Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

Abstract

The present invention relates to cosmetic technical fields, more particularly to a kind of crease-resistant tender skin essence cream.The crease-resistant tender skin essence includes millet polypeptide powder, Nano pearl powder, chlorella extract, tremella polysaccharides, natural plants essence, Cer NP, olive oil, saualane, Sodium Hyaluronate, glycerol, sodium lactate, pyrrolidone sodium carboxylate, antioxidant, polysorbate -20, mountain spring appropriate amount of water.The present invention easily absorbs, skin-moisturizing, skin according to skin biological rhythm, good penetrability, effectively reparation wrinkle of skin, inhibits wrinkle regeneration, and delay skin aging is high with skin biology fitness.

Description

A kind of crease-resistant tender skin essence
Technical field
The present invention relates to cosmetic technical field, more particularly to a kind of crease-resistant tender skin essence cream, the crease-resistant tender skin essence creams Moisturizing maintenance composition is for body skin nursing, nourishing skin.
Background technique
Skin is generally divided into epidermis, corium, subcutaneous tissue three parts, and containing accessory organ (sweat gland, sebaceous glands, nail, Toenail) and blood vessel, lymphatic vessel, nerves and muscles etc..Its mesocuticle is divided into cuticula again, and stratum granulosum has spinous layer, basal layer four Part.Cuticula is skin outermost layer, is an important barrier of epidermis, can prevent extraneous bacterium, virus etc. from invading, protection Skin and the effect for preventing skin moisture from being lost.
Wherein, sebaceous glands can form on the skin a tunic, this tunic with sebum secreted, the sebum of smegma It is weakly acidic, it is natural face cream for skin, regulates and controls the balance of moisture of skin, maintenance natural barrier effect has profit Sliding skin makes skin bright and new bright, skin surface is helped to have flexibility, mitigates the stimulation that friction generates, prevent skin itself Natural moisturizing factor and moisture content scatter and disappear, prevent from having dry skin, protect invasion of the skin not by bacterium or foreign substance.
There are substantial connection at the secretory activity of sebaceous glands and age, and from pubarche, smegma activity is increasingly vigorous, As long as about 10-15 being continued.Generally sebum gradually decreased since 30 years old or so, and skin starts aging, and above-mentioned protection is made With weakening, in order to avoid these phenomenons, it is important to protect sebum.
Skin aging refers to that skin function Aging damages, and makes skin to the protective capacities of body, and regulating power etc. declines, Thus skin does not adapt to the variation of internal and external environment, the change of the appearances integral status such as color, color, form, texture occurs.Skin The aging of skin is divided into intrinsic aging and extrinsic aging.Intrinsic aging refers to the natural aging that skin increases with the age.Table It is now whiteness of skin, fine wrinkles, flexibility decrease, cutis laxa etc. occurs.Extrinsic aging is main the reason is that solarization institute The light aging of cause.Show as wrinkle, cutis laxa, coarse, Beige color dermatodyschroia, telangiectasis, pigment Spot is formed.
Ceramide (ceramide) is also known as sphingolipid, is naturally occurring a kind of lipid in skin, cuticula The sebum of middle 40%-50% is made of ceramide, and ceramide is the major part of intercellular matrix, is keeping cuticlar water It plays an important role in the balance divided.In simple terms, cuticula is one of city wall for protecting skin, and ceramide is exactly to form " brick " of this road city wall.With advancing age, the water loss of skin is more serious, and the ceramide in skin is reduced, skin The keratinocyte adhesion strength of skin also declines therewith, can become obscure drying.When drying, furfur, cracking phenomena, screen occurs in skin When barrier function is substantially reduced, skin supplement ceramide can restore rapidly moisturizing and barrier function.The type of ceramide is more, The ceramide ingredient for uniquely meeting human epidermal layer reparation is exactly the Cer NP of neutral type, the reparation effect of its Stratum Corneum Fruit can achieve 93.1%.But ceramide percutaneous absorbability is poor, and it is unsatisfactory that moistening effect is used alone.Moreover, existing Cosmetics lack the good contact with human skin, and air-moisture-permeable effect is unobvious, therefore, solve ceramide infiltration and inhale It receives, it is particularly important to develop the green natural cosmetics high with skin biology fitness.
Summary of the invention
The present invention provides a kind of crease-resistant tender skin essence, and good penetrability easily absorbs, skin-moisturizing, skin, effectively repairs skin wrinkle Line, inhibits wrinkle regeneration, and delay skin aging is high with skin biology fitness.
In order to achieve the purpose that invention, the present invention provides a kind of crease-resistant tender skin essence, which is characterized in that wraps by weight Contain:
Preferably,
The mountain spring water passes through karst lava stratum permeation filtration layer by layer, is rich in several mineral materials and microelement, PH Value is in alkalescent, is the natural nano grade small-micelle water being easily absorbed by the human body.
Preferably,
The natural plants essence is selected from jasmine essential oil, rose ethereal oil, cape jasmine flower essential oil, osmanthus essential oil, lavender One of essential oil, Jojoba essential oil.
Preferably,
The antioxidant is selected from least one of vitamin E, reduced glutathione, Co-Q10.
Preferably,
The chlorella extract the preparation method comprises the following steps: chlorella powder and water is added with the amount that volume ratio is 1:1, in 55- Ultrasound homogenizes at 65 DEG C, chlorella aqueous solution and ethanol solution is added for the amount of 1:3 with volume ratio, after mixing evenly static 5h, Extraction filtering is to get chlorella extract.
Preferably,
The crease-resistant tender skin essence is essence lotion, essence cream, essence cream, essence hydrosol.
A kind of crease-resistant tender skin essence cream, which is characterized in that
Include by weight:
A kind of preparation method of crease-resistant tender skin essence cream, raw material used is by weight, it is characterised in that including following Step:
(1) 3-5 parts of Sodium Hyaluronate, 3-5 parts of glycerol, 3-5 parts of sodium lactate, 4-6 parts of pyrrolidone sodium carboxylate are being stirred Under be slowly added to be uniformly dispersed in appropriate 60-80 DEG C of mountain spring water, standing is cooled to 40 DEG C, be added olive oil 6-10 part, it is neural 3 3-5 parts of amide, 5-8 parts of saualane 8min is stirred in homogenizer；
(2) by 8-10 parts of millet polypeptide powder, 6-8 parts of Nano pearl powder, 3-5 parts of chlorella extract, 3-5 parts of tremella polysaccharides Appropriate mountain spring water is added to stir evenly；
(3) it is heated to 70-75 DEG C by -20 2-3 parts of polysorbate, after carrying out emulsifying 5min with ultrasonic machine, stood 40 DEG C are cooled to, then the substance in step (2) is added, stirring 5min makes it uniformly；
(4) by the material mixing in step (1), (3), antioxidant 5-8 parts, 5-7 parts of natural plants essence is added, in right amount Mountain spring water is stood after mixing evenly, obtains the essence cream.
The olive oil that the present invention uses is the not heated and chemical place as made of the fresh direct cold press of olive fruit Reason, remains natural nutrient component.Olive oil is considered as the grease that human nutrition is most suitable in the grease found so far.Olive Olive oil be rich in the squalene and essential fatty acid splendid with skin affinity, absorb rapidly, effectively keep skin elasticity and It is moist；Contained monounsaturated fatty acids abundant and vitamin E, K, A, D etc. and phenols antioxidant, can eliminate in olive oil Facial wrinkles prevent skin aging, effectively enhance skin elasticity, have skin or hair care and prevention and treatment hand and foot from chapping and other effects, being can With the cosmetics and skincare product of " eating ", in addition can resist ultraviolet light with olive oil smearing skin prevents cutaneum carcinoma.Carrot in olive oil Element and chlorophyll assign olive oil yellow green, and chlorophyll plays metabolism, promote cell growth, accelerating wound healing. The appearance for additionally aiding beautification people, reduces the generation of wrinkle.The antioxidant that olive oil contains can eliminate interior free yl, extensive The health status of multiple viscera organ, can prevent brain aging, and can promote longevity.
Saualane (Squalane) is that the hydrogenated obtained one kind of squalene extracted from hydrogenated hydro carbons grease is had excellent performance Squalene extracting, it is also known as eepwater shark liver oils.Saualane is that rare chemical stability is high, the splendid animal oil of use feeling Rouge has preferable compatibility to skin, will not cause allergy and stimulation, and can accelerate formula in other active components into skin Infiltration；With lower polarity and medium spreadability, and pure, colourless, free from extraneous odour；It may also suppress the growth of mould.
Sodium lactate can effectively treat skin disorders.As: extremely dry symptom caused by dermatoxerasia etc.. It is usually used in combination with many other effective components, generates synergy.Pfansteihl sodium is also widely used as skin care item simultaneously Moisturizing agent, can make skin keep moisture content, reduce wrinkle.Sodium lactate is natural moisturizing factor, four points in the keratoderma of people One of ingredient be sodium lactate.Sodium lactate prevents moisture of skin for that can form hydration shell with other chemical analysis in cosmetics Volatilization, makes the high-quality light moisture state of skin, prevents wrinkle from generating, be widely used as the moisturizing agent of skin care item.Lactic acid can be used as Skin whitener of new generation can produce synergy when being used cooperatively with other skin whiteners.
Pyrrolidones carboxylic sodium is water-soluble, and under synthermal and concentration, L- pyrrolidones carboxylic sodium viscosity is more than other moisturizings Agent is low, that sticky thick and heavy feeling without glycerol, and highly-safe, to skin, eye mucosa almost without irritation, while with There are also good concertednesses for other moisturizer, and mixing use has good effect.
Chlorella extract is taken from rich in a variety of nutrition such as protein, lipid, carbohydrate, vitamin, minerals The chlorella of substance.Chlorella is under the jurisdiction of Chlorella cell Chlorophyceae, contained by biological active agents have acceleration thin The effect that bacterium, animal and plant are grown.The main component of chlorella extract is chlorella growth factor, chlorella growth factor Nucleic acid and nucleoprotein rich in can repair human body cell and have the function of anti-aging, and there are also the works of immune cell activated With having very strong binding force with toxin and toxin can be excluded external.Therefore, chlorella growth factor has good work to skin With.
Mountain spring water used in the present invention be by karst lava stratum permeation filtration layer by layer, rich in several mineral materials and Microelement, pH value are in alkalescent, the natural nano grade small-micelle water being easily absorbed by the human body.Nanoscale subset water energy is fast Speed fusion nutriment infiltrates into deep skin, can penetrating cell centre bore, into nucleus, be cell inner layer in a steady stream not Disconnected conveying water source, is the abundant moisturizing of human body cell, and be not lost, and enables skin moment water profit full.Mountain spring used in the present invention Water while entering intracellular, sweat by movable because of human body, and the rubbish of intracellular metabolism is taken out of external.No It only as the delivery vehicles of nutriment, and is the motive force of skin metabolism.
The millet polypeptide powder that the present invention uses radicals scavenging function with higher, stronger bacteriostasis and antioxygen Change, antibacterial activity, there is facilitation to cellular immunity.Millet polypeptide molecular weight is small, and activity is strong, and free radical with higher is clear Except function, stronger bacteriostasis and anti-oxidant, antibacterial activity.Also have mitigation wrinkle, color spot, pigment heavy with spot-eliminating beauty treatment The effect of.
The present invention has found Cer NP and olive oil and spiny dogfish during solving the problems, such as the osmotic absorption of ceramide Alkane three is used in compounding, and has synergistic effect, not only optimizes the permeability of ceramide and both effectiveness, also solves neural acyl The generality problem of amine usability.
When Cer NP, olive oil and saualane three are used in compounding in the preparation process, by testing autonomous learning Determine the parts by weight between the Cer NP and olive oil and saualane, wherein the step of autonomous learning is as described below:
The Cer NP and olive oil and the triangular compounding of saualane of P different weight part are carried out first, described in record The value of the respective parts by weight of three when P three's compounding forms deal matrix X, and the X includes the column of P row 3, meanwhile, pass through Transdermal penetration experiment detect the three compounding when ceramide permeability, save as vector Y, by the matrix X and to Amount Y brings formula (1) into and obtains the permeability through amide and the relationship expression between Cer NP and olive oil and saualane Formula；
Wherein, L is relational expression,For the coefficient of relationship of required solution, Xi, 1 is The parts by weight of the Cer NP of the i-th data of matrix X, Xi,2For the parts by weight of the olive oil of the i-th data of matrix X, Xi,3 For the parts by weight of the saualane of the i-th data of matrix X, Π is pi, YiFor i-th of value of vector Y, i=1,2,3 ... P calculates the coefficient of relationship using formula (2)Value；
Wherein, e is natural constant, is contained in the formula (2)6 unknown numbers, together When formula (2) in contain 6 equation groups, then the coefficient of relationship can be obtained using formula (2)By the coefficient of relationship bring into formula (3) solve the Cer NP and olive oil and The optimal parts by weight of saualane；
Wherein, X1For the optimal parts by weight for solving obtained Cer NP, X2For the optimal parts by weight of olive oil, X3 is angle The optimal parts by weight of shark alkane, ln are the logarithm using e the bottom of as.
By above-mentioned technology, the Cer NP and olive oil and angle can be determined by multiple experiment autonomous learning Parts by weight between shark alkane, under the experiment autonomous learning between obtained Cer NP and olive oil and saualane Parts by weight can make the permeability of the ceramide after three's compounding most strong, and because be in carrying out to the result of many experiments In the analysis of relationship, obtained internal relation, so that the parts by weight calculated have objectivity, non-artificial subjective control Or experimental situation difference and caused by, with more science.
Beneficial effect
1, product of the present invention easily absorbs, skin-moisturizing, skin, effectively reparation wrinkle of skin, inhibits wrinkle regeneration, and delaying skin declines Always, high with skin biology fitness.
2, the millet polypeptide powder radicals scavenging function with higher that the present invention that the present invention uses uses, stronger suppression Bacterium ability and anti-oxidant, antibacterial activity have facilitation to cellular immunity.Millet polypeptide molecular weight is small, and activity is strong, have compared with High radicals scavenging function, stronger bacteriostasis and anti-oxidant, antibacterial activity.Also have with spot-eliminating beauty treatment and mitigates wrinkle The effect of line, color spot, pigmentation.
3, the present invention can promote the transdermal suction of ceramide using ceramide by acting synergistically with olive oil, saualane It receives, moistening effect is good.
4, present invention uses natural plant essence, facilitate skin benign development.
5, present invention addition Nano pearl powder, natural whiting is sun-proof, carries out prevention maintenance from the sun-proof angle of skin aging.
6, present invention addition antioxidant vitamin E, reduced glutathione, Co-Q10 resist radical damage, prevent Wrinkle generates.
Specific embodiment
The preparation of chlorella extract:
Chlorella powder and water is added for the amount of 1:1 with volume ratio, ultrasound homogenizes at 60 DEG C, is the amount of 1:3 with volume ratio Chlorella aqueous solution and ethanol solution is added, after mixing evenly static 5h, extraction filtering is to get chlorella extract.
Embodiment 1
Raw material used by weight,
(1) 3 parts of Sodium Hyaluronate, 3 parts of glycerol, 3 parts of sodium lactate, 4 parts of pyrrolidone sodium carboxylate are slowly added under stiring Enter in 60 DEG C 25 parts of mountain spring water and be uniformly dispersed, standing is cooled to 40 DEG C, and 6 parts of olive oil, 3 parts of Cer NP, spiny dogfish is added 5 parts of alkane are stirred 8min in homogenizer；
(2) by 3 parts of 8 parts of millet polypeptide powder, 6 parts of Nano pearl powder, 3 parts of chlorella extract, tremella polysaccharides addition mountain springs 30 parts of water stir evenly；
(3) 70 DEG C are heated to by 2 parts of polysorbate -20, after carrying out emulsifying 5min with ultrasonic machine, stand cooling It is added to 40 DEG C, then by the substance in step (2), stirring 5min makes it uniformly；
(4) by the material mixing in step (1), (3), 5 parts of reduced glutathione, 2 parts of Co-Q10, rose is added It 5 parts of essential oil, 15 parts of mountain spring water, stands after mixing evenly, obtains the essence cream.
Embodiment 2
Raw material used by weight,
(1) 5 parts of Sodium Hyaluronate, 4 parts of glycerol, 5 parts of sodium lactate, 5 parts of pyrrolidone sodium carboxylate are slowly added under stiring Enter in 80 DEG C 30 parts of mountain spring water and be uniformly dispersed, standing is cooled to 40 DEG C, and 9 parts of olive oil, 5 parts of Cer NP, spiny dogfish is added 8 parts of alkane are stirred 8min in homogenizer；
(2) by 5 parts of 10 parts of millet polypeptide powder, 8 parts of Nano pearl powder, 5 parts of chlorella extract, tremella polysaccharides addition mountain springs 35 parts of water stir evenly；
(3) 75 DEG C are heated to by 2 parts of polysorbate -20, after carrying out emulsifying 5min with ultrasonic machine, stand cooling It is added to 40 DEG C, then by the substance in step (2), stirring 5min makes it uniformly；
(4) by the material mixing in step (1), (3), 6 parts of vitamin E, 6 parts of Lavender, appropriate mountain spring water is added It 15 parts, stands after mixing evenly, obtains the essence cream.
Embodiment 3
Raw material used by weight,
(1) 4 parts of Sodium Hyaluronate, 4 parts of glycerol, 4 parts of sodium lactate, 4 parts of pyrrolidone sodium carboxylate are slowly added under stiring Enter in 70 DEG C 30 parts of mountain spring water and be uniformly dispersed, standing is cooled to 40 DEG C, and 10 parts of olive oil, 4 parts of Cer NP, spiny dogfish is added 6 parts of alkane are stirred 8min in homogenizer；
(2) by 4 parts of 9 parts of millet polypeptide powder, 7 parts of Nano pearl powder, 4 parts of chlorella extract, tremella polysaccharides addition mountain springs 30 parts of water stir evenly；
(3) 73 DEG C are heated to by 3 parts of polysorbate -20, after carrying out emulsifying 5min with ultrasonic machine, stand cooling It is added to 40 DEG C, then by the substance in step (2), stirring 5min makes it uniformly；
(4) by the material mixing in step (1), (3), 7 parts of Co-Q10,6 parts of Jojoba essential oil, mountain spring water 25 is added Part, it stands after mixing evenly, obtains the essence cream；
When Cer NP, olive oil and saualane three are used in compounding in the preparation process, by testing autonomous learning Determine the parts by weight between the Cer NP and olive oil and saualane, wherein the step of autonomous learning is as described below:
The Cer NP and olive oil and the triangular compounding of saualane of P different weight part are carried out first, described in record The value of the respective parts by weight of three when P three's compounding forms deal matrix X, and the X includes the column of P row 3, meanwhile, pass through Transdermal penetration experiment detect the three compounding when ceramide permeability, save as vector Y, by the matrix X and to Amount Y brings formula (1) into and obtains the permeability through amide and the relationship expression between Cer NP and olive oil and saualane Formula；
Wherein, L is relational expression,For the coefficient of relationship of required solution, Xi,1For square The parts by weight of the Cer NP of the i-th data of battle array X, Xi,2For the parts by weight of the olive oil of the i-th data of matrix X, Xi,3For The parts by weight of the saualane of the i-th data of matrix X, Π are pi, YiFor i-th of value of vector Y, the P of i=1,2,3 ..., The coefficient of relationship is calculated using formula (2)Value；
Wherein, e is natural constant, is contained in the formula (2)6 unknown numbers, together When formula (2) in contain 6 equation groups, then the coefficient of relationship can be obtained using formula (2)The coefficient of relationship is brought into formula (3) to ask
Solve the optimal parts by weight of the Cer NP and olive oil and saualane；
Wherein, X1For the optimal parts by weight for solving obtained Cer NP, X2For the optimal parts by weight of olive oil, X3 is angle The optimal parts by weight of shark alkane, ln are the logarithm using e the bottom of as.
Comparative example 1
Preparation process is free of olive oil, Cer NP, saualane with embodiment 2, essence cream.
Comparative example 2
Preparation process is free of olive oil, saualane with embodiment 2, essence cream.
Comparative example 3
Preparation process is free of small mpd polypeptide with embodiment 2, essence cream.
Comparative example 4
Preparation process is with embodiment 2, essence cream not chlorella extract-containing.
Properties of product test
1, stability test:
Embodiment 1-3:
Heat-resistant stability investigates (48 DEG C × 40d): qualified
Cold-resistant study on the stability (- 15 DEG C × 40d): qualified
(4000r/min, 30min) is investigated in centrifugation: qualified
2, hygienic requirements:
Essence made from embodiment 1-3 meets the relevant regulations of " cosmetics health specification " (version in 2007).
3, human safety is tested:
Tested crowd's number: 60 people, the age: between 20-40 years old,
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
It is divided into 3 groups, every group of 20 people respectively test the product of embodiment 1-3.
Patch spot method: qualified spot tester is selected, with closed patch experiment method, by tested material about 0.02g-0.03g It drips in spot tester, external application special adhesive tape is covered on subject back, 0.5,6,12,24,48 hour observation skin after removing respectively Skin reaction, records its result according to dermoreaction grade scale in " cosmetics health specification " (version in 2007).
Test result:
Human skin patch test result is shown: each group subject by the patch test of embodiment 1-3,0.5,6, 12, it is safe to illustrate that product of the invention uses wherein 0 skin adverse reaction occurs for observation dermoreaction in 24,48 hours.
4, moistening effect is tested
It is tested using Corneometer- capacitance method, instrument used is Corneometer CM825.
The test of keratoderma hydration rate: working principle is using capacitor as instrument probe, since water is medium on skin The maximum substance of constant, when skin moisture content changes, the capacitance of skin also changes, it is possible to pass through survey Determine skin pricktest capacitance, analyzing skin surface moisture content.By measuring the variation using keratoderma capacitance before and after product The variation of water content of stratum corneum is measured, thus to evaluate the moisture-keeping efficacy of product, moisture of such method to keratoderma Content carries out quantification, can delicately react the variation of skin moisture content, and favorable reproducibility.
Tested crowd's number: 70 people, the age: between 20-40 years old,
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
It is divided into 7 groups, every group of 10 people respectively test embodiment 1-3, comparative example 1-4.
Experimental method: side is bent in candidate or so forearm and marks 3 × 3cm2The square Experimental Area of size, is made with right arm For the test zone of moisturizer, uniform smearing 0.1g every square centimeter, the corresponding symmetrical region of left arm is blank control, is then examined Result is found out average value by the moisture content for surveying everyone experiment position.With formula (1) calculated hydration rate.
Hydration rate=(test value-blank value)/blank value × 100% formula (1)
The results are shown in Table 1:
Table 1
The moistening effect of essence cream of the present invention is good, and skin moisture content can be effectively improved after use, can be reduced the dry line of face, Microgroove keeps skin moist.
5, product effect assessment
Tested crowd's number: 140 people, the age: between 20-40 years old,
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
It is divided into 7 groups, every group of 20 people respectively test embodiment 1-3, comparative example 1-4.
Test method: example 1-3 and comparative example 1-3 is used respectively, observes and experience using effect.
Application method: after subject cleans face, take suitable essence cream in the palm of the hand, uniformly point is applied to face skin, gently Forlement is until fully absorb, and comparative example 3 is each using once daily morning and evening, and embodiment 1-5, comparative example 1, comparative example 2 are early Upper daily essence cream, is adhered to ight essence cream using one month at night, at least checks that once whether there is or not whole bodies to understand weekly And local adverse reaction, and record in detail is as a result, examination assessment result such as table 2.
Table 2
Essence of the present invention cream easily absorbs, skin sense is salubrious, can repair microgroove, dry line, wrinkle, and whole cosmetic result is good, and right Ratio is compared, without containing olive oil, Cer NP, saualane ingredient product effect can be weaker, do not contain olive oil, angle The product of shark alkane ingredient is also without the effect significant change because of increase Cer NP.Small mpd polypeptide and chlorella extract energy Play the role of mitigating wrinkle, beautifying and antisenility.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies Within, then the present invention is also intended to include these modifications and variations.

Claims (9)

1. a kind of crease-resistant tender skin essence, which is characterized in that include by weight:
2. the crease-resistant tender skin essence of one kind according to claim 1, which is characterized in that
The mountain spring water passes through karst lava stratum permeation filtration layer by layer, is rich in several mineral materials and microelement, and pH value is in Alkalescent is the natural nano grade small-micelle water being easily absorbed by the human body.
3. the crease-resistant tender skin essence of one kind according to claim 2, which is characterized in that
The natural plants essence be selected from jasmine essential oil, rose ethereal oil, cape jasmine flower essential oil, osmanthus essential oil, Lavender, One of Jojoba essential oil.
4. the crease-resistant tender skin essence of one kind according to claim 3, which is characterized in that
The antioxidant is selected from least one of vitamin E, reduced glutathione, Co-Q10.
5. the crease-resistant tender skin essence of one kind according to claim 1, which is characterized in that
The chlorella extract the preparation method comprises the following steps: chlorella powder and water is added with the amount that volume ratio is 1:1, at 55-65 DEG C Lower ultrasound homogenizes, and chlorella aqueous solution and ethanol solution is added for the amount of 1:3 with volume ratio, after mixing evenly static 5h, extraction Filtering is to get chlorella extract.
6. -5 any one crease-resistant tender skin essence according to claim 1, it is characterised in that:
The crease-resistant tender skin essence is one of essence lotion, essence cream, essence cream, essence hydrosol.
7. the crease-resistant tender skin essence cream of one kind according to claim 4, which is characterized in that
Include by weight:
8. a kind of preparation method of crease-resistant tender skin essence cream, raw material used is by weight, it is characterised in that including following step It is rapid:
(1) by 3-5 parts of Sodium Hyaluronate, 3-5 parts of glycerol, 3-5 parts of sodium lactate, 4-6 parts of pyrrolidone sodium carboxylate it is slow under stiring Slowly it is added in appropriate 60-80 DEG C of mountain spring water and is uniformly dispersed, standing is cooled to 40 DEG C, and olive oil 6-10 parts, Cer NP is added 3-5 parts, 5-8 parts of saualane are stirred 8min in homogenizer；
(2) by 8-10 parts of millet polypeptide powder, 6-8 parts of Nano pearl powder, 3-5 parts of chlorella extract, 3-5 parts of tremella polysaccharides additions Appropriate mountain spring water stirs evenly；
(3) it is heated to 70-75 DEG C by -20 2-3 parts of polysorbate, after carrying out emulsifying 5min with ultrasonic machine, stands cooling It is added to 40 DEG C, then by the substance in step (2), stirring 5min makes it uniformly；
(4) by the material mixing in step (1), (3), antioxidant 5-8 parts, 5-7 parts of natural plants essence, appropriate mountain spring is added Water is stood after mixing evenly, obtains the essence cream.
9. the preparation method of the crease-resistant tender skin essence cream of one kind according to claim 8, which is characterized in that
When Cer NP, olive oil and saualane three are used in compounding in the preparation process, determined by experiment autonomous learning Parts by weight between the Cer NP and olive oil and saualane, wherein the step of autonomous learning is as described below:
The Cer NP and olive oil and the triangular compounding of saualane of P different weight part of progress first, records P times described Three compound when the respective parts by weight of three value, formed deal matrix X, the X include P row 3 arrange, meanwhile, pass through through Skin permeability test detects the permeability of the ceramide when three compounds, and vector Y is saved as, by the matrix X and vector Y It brings formula (1) into and obtains the permeability through amide and the relational expression between Cer NP and olive oil and saualane；
Wherein, L is relational expression,β1、β2、β3For the coefficient of relationship of required solution, Xi,1It is i-th of matrix X The parts by weight of the Cer NP of data, Xi,2For the parts by weight of the olive oil of the i-th data of matrix X, Xi,3It is the i-th of matrix X The parts by weight of the saualane of data, Π are pi, YiFor i-th of value of vector Y, the P of i=1,2,3 ... utilizes formula (2) coefficient of relationship is calculatedβ1、β2、β3Value；
Wherein, e is natural constant, is contained in the formula (2)β1、β2、β3, 6 unknown numbers, while formula (2) In contain 6 equation groups, then can obtain the coefficient of relationship using formula (2)β1、β2、β3, by the relationship Coefficient brings the optimal parts by weight that formula (3) solves the Cer NP and olive oil and saualane into:
Wherein, X1For the optimal parts by weight for solving obtained Cer NP, X2For the optimal parts by weight of olive oil, X3 is saualane Optimal parts by weight, ln is logarithm using e the bottom of as.
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110680760A (en) * 2019-10-18 2020-01-14 广州睿森生物科技有限公司 Composition containing composite peptide nanoemulsion and application of composition in preparation of cosmetics
CN111467286A (en) * 2020-05-15 2020-07-31 万京创科(山东)生物科技有限公司 Millet compound fermentation product and preparation method and application thereof
CN111658554A (en) * 2019-11-19 2020-09-15 深圳市婵小君化妆品有限公司 Cosmetic based on small molecular group water and preparation method thereof
CN112391433A (en) * 2020-11-09 2021-02-23 山东发现生物技术有限公司 Human cell polypeptide extraction and application method
CN113181085A (en) * 2021-04-29 2021-07-30 广州睿森生物科技有限公司 Composition matrix for improving skin problems after makeup and application of composition matrix in cosmetics
CN114762663A (en) * 2021-10-14 2022-07-19 广州极男化妆品有限公司 Moisturizing composition and preparation method and application thereof
CN115089502A (en) * 2022-08-15 2022-09-23 李瑶 Moisturizing essence milk and preparation method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05922A (en) * 1991-06-26 1993-01-08 Kurooda Japan Kk Cosmetic composition
JPH05117129A (en) * 1991-10-24 1993-05-14 Kurooda Japan Kk Skin external agent
FR2941376A1 (en) * 2009-01-28 2010-07-30 Limousine D Applic Biolog Dite Cosmetic use of an active ingredient obtained from Panicum miliaceum having oligopeptides, as antistress and/or antiaging ingredient in a composition
KR20110013147A (en) * 2009-07-31 2011-02-09 (주)아모레퍼시픽 Cosmetic composition containing polymersomes encapsulated peptides or hydrolyzed millet
CN102176894A (en) * 2008-10-10 2011-09-07 强生消费者公司 Shine control cleanser
CN104203207A (en) * 2012-03-26 2014-12-10 Otc有限责任公司 Hair conditioning composition for permanent and semi-permanent hair coloration applications
CN108420767A (en) * 2018-05-15 2018-08-21 上海东晟源日化有限公司 It is a kind of that there are the crease-resistant skin care item to compact with U.S. face moisture-keeping efficacy

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05922A (en) * 1991-06-26 1993-01-08 Kurooda Japan Kk Cosmetic composition
JPH05117129A (en) * 1991-10-24 1993-05-14 Kurooda Japan Kk Skin external agent
CN102176894A (en) * 2008-10-10 2011-09-07 强生消费者公司 Shine control cleanser
FR2941376A1 (en) * 2009-01-28 2010-07-30 Limousine D Applic Biolog Dite Cosmetic use of an active ingredient obtained from Panicum miliaceum having oligopeptides, as antistress and/or antiaging ingredient in a composition
KR20110013147A (en) * 2009-07-31 2011-02-09 (주)아모레퍼시픽 Cosmetic composition containing polymersomes encapsulated peptides or hydrolyzed millet
CN104203207A (en) * 2012-03-26 2014-12-10 Otc有限责任公司 Hair conditioning composition for permanent and semi-permanent hair coloration applications
CN108420767A (en) * 2018-05-15 2018-08-21 上海东晟源日化有限公司 It is a kind of that there are the crease-resistant skin care item to compact with U.S. face moisture-keeping efficacy

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
吴练军: "方便杂粮粥配方设计及其工艺优化", 《中国优秀博硕士学位论文全文数据库(硕士)工程科技Ⅰ辑》 *
宋晓秋: "《化妆品原料学》", 31 July 2018, 中国轻工业出版社 *
张卓敏: "黑龙江省小米主栽品种理化特性与感官品质的相关性研究", 《中国优秀博硕士学位论文全文数据库(硕士)工程科技Ⅰ辑》 *
王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 *
田广林等: "《红山文化论著粹编.综合研究卷》", 31 December 2015, 辽宁师范大学出版社 *
郭宪: "《说说作物》", 31 August 2013, 重庆大学出版社 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110680760A (en) * 2019-10-18 2020-01-14 广州睿森生物科技有限公司 Composition containing composite peptide nanoemulsion and application of composition in preparation of cosmetics
CN110680760B (en) * 2019-10-18 2022-04-05 广州睿森生物科技有限公司 Composition containing composite peptide nanoemulsion and application of composition in preparation of cosmetics
CN111658554A (en) * 2019-11-19 2020-09-15 深圳市婵小君化妆品有限公司 Cosmetic based on small molecular group water and preparation method thereof
CN111467286A (en) * 2020-05-15 2020-07-31 万京创科(山东)生物科技有限公司 Millet compound fermentation product and preparation method and application thereof
CN112391433A (en) * 2020-11-09 2021-02-23 山东发现生物技术有限公司 Human cell polypeptide extraction and application method
CN113181085A (en) * 2021-04-29 2021-07-30 广州睿森生物科技有限公司 Composition matrix for improving skin problems after makeup and application of composition matrix in cosmetics
CN114762663A (en) * 2021-10-14 2022-07-19 广州极男化妆品有限公司 Moisturizing composition and preparation method and application thereof
CN115089502A (en) * 2022-08-15 2022-09-23 李瑶 Moisturizing essence milk and preparation method thereof

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Application publication date: 20190726