CN108434021B - Hump fat hand cream with skin moistening and anti-cracking effects and preparation method thereof - Google Patents
Hump fat hand cream with skin moistening and anti-cracking effects and preparation method thereof Download PDFInfo
- Publication number
- CN108434021B CN108434021B CN201810561313.2A CN201810561313A CN108434021B CN 108434021 B CN108434021 B CN 108434021B CN 201810561313 A CN201810561313 A CN 201810561313A CN 108434021 B CN108434021 B CN 108434021B
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- skin
- hand cream
- stirring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/12—Production of fats or fatty oils from raw materials by melting out
- C11B1/14—Production of fats or fatty oils from raw materials by melting out with hot water or aqueous solutions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/001—Refining fats or fatty oils by a combination of two or more of the means hereafter
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a skin-moistening anti-cracking hand cream and a preparation method thereof, wherein the skin-moistening anti-cracking hand cream contains camel oil, lanoline, an emulsifier, an emollient, a humectant, a preservative, a thickener, essence and other components. The skin moistening and anti-cracking hand cream disclosed by the invention is yellowish and bright in cream color, fine and smooth in texture, free of stimulation to skin, good in appearance, appropriate in viscosity, fine and uniform in cream body, good in spreadability, very fine and smooth in skin luster after being applied, very good in moistening effect and the like.
Description
[ technical field ] A method for producing a semiconductor device
The invention belongs to the technical field of cosmetics. More specifically, the invention relates to a hump fat hand cream with skin moistening and anti-cracking effects, and also relates to a preparation method of the hump fat hand cream with skin moistening and anti-cracking effects.
[ background of the invention ]
Some research works find that natural, pollution-free and multifunctional cosmetics are the main development trend of beauty products along with diversification of living elements, and the development situation and the consumption psychology of the beauty products are constantly changed. According to the records of materia medica gang mu, hump fat has the efficacy of mainly treating obstinate arthralgia, malignant sore, swelling, muscle stiffness and the like. The hump fat is mainly derived from hump fat and is obtained by boiling, dissolving and purifying hump fat with water. Therefore, the development of more updated functional products by utilizing the camel fat has important significance.
The hump fat contains rich natural nutrients, highly unsaturated fatty acid and rich vitamin E, and has small diameter of fat ball, strong permeability and easy absorption by skin, and is rich in immunocompetent substances which can promote the self-healing ability and metabolism of human body, promote the regeneration of new cells, relieve pain, resist bacteria and diminish inflammation. The results of the study show that the crude fat content in the bactrian camel peak is about 90 percent. Camel fat was detected to contain 14 fatty acids with the highest oleic acid content (about 31%), followed by stearic acid content (about 26%) and palmitic acid content (about 21%). Research shows that oleic acid and palmitic acid can be used as emollients in cosmetics, and can form a thin protective layer on the surface of skin, so that the skin can enjoy the benefits similar to sebum per se, and simultaneously, the water loss can be prevented, and the moisturizing required by dry skin can be provided. Stearic acid can be used as a softening agent, a surfactant and a stabilizer in cosmetics, can improve the emulsifying capacity of the components, enables the components to be better mixed with each other, controls the system to have proper surface tension in the foaming process, generates a good bubble network structure and enhances the stability of the system. In conclusion, the camel peak fat applied to the hand cream can moisten hand skin, keep moisture for a long time, has good stability and effectively improves the condition of skin chapping. The skin care product has the great characteristic of wide attention, good permeation effect and better absorption by skin. Most skin care products, especially hand cream, lose a large part of the skin due to friction after being applied and people frequently wash hands, and the hand cream is also a loss reason, so that the rapid penetration into the skin is also the focus of the invention.
Due to the lagging processing technology, the deep processing rate of the animal oil is very low, so that a large amount of animal oil is wasted in China every year. In recent years, studies on refining animal fats and oils have been receiving attention. At present, camel milk soap, camel milk facial mask and the like are researched to a certain extent, but the utilization of camel oil is very little, the manufacture of camel oil hand cream is still in a primary stage, researchers think that the development and research of camel oil hand cream can increase the types of hand cream and camel oil products, and the camel oil hand cream has great market potential and development prospect, and can improve the economic benefit of herdsmen. In addition, the research on the processing technology of the hump oil hand cream can also provide a certain basis for the processing technology and the improvement of the quality of hump oil ointments in the future.
[ summary of the invention ]
[ problem to be solved ]
The invention aims to provide hump fat hand cream with skin moistening and anti-cracking effects.
The invention also aims to provide a preparation method of the hump fat hand cream with the effects of moisturizing skin and preventing chapping.
[ solution ]
The invention is realized by the following technical scheme.
The invention relates to a hump fat hand cream with skin moistening and anti-cracking effects.
The camel hair fat skin-moistening anti-cracking hand cream comprises the following components: in parts by weight
Deionized water was made up to 100 parts.
According to a preferred embodiment of the invention, the moisturizer is one or more moisturizers selected from the group consisting of glycerol, propylene glycol, hyaluronic acid, petrolatum or caprylic/capric triglyceride.
According to another preferred embodiment of the invention, said emulsifier is one or more emulsifiers selected from the group consisting of glyceryl monostearate, tween 80 and span 80.
According to another preferred embodiment of the present invention, the emollient is one or more selected from the group consisting of dimethicone, ethylhexyl glycerin, cetyl alcohol, and jojoba oil.
According to another preferred embodiment of the present invention, the thickener is one or more thickeners selected from carbomers, xanthan gum, stearic acid or hydroxyethyl acrylate acrylamide sodium taurate copolymers.
According to another preferred embodiment of the present invention, the preservative is one or more preservatives selected from isothiazolidinone, phenoxyethanol, methylparaben or propylparaben.
According to another preferred embodiment of the present invention, the essence is papaya essence or lavender essence.
According to another preferred embodiment of the invention, the antioxidant is tocopheryl acetate.
The invention also relates to a preparation method of the hump fat hand cream.
The method comprises the following steps:
A. preparation of an oil phase mixture
Mixing 4-10 parts by weight of camel oil, 0.1-3.0 parts by weight of lanolin, 1-3 parts by weight of emulsifier, 2-5 parts by weight of emollient, 0.8-3.6 parts by weight of humectant and 0.06-0.15 part by weight of preservative, and stirring at 75-80 ℃ until the raw materials are completely dissolved to obtain the oil phase mixture;
B. preparation of an aqueous mixture
Mixing 1-3 parts by weight of emulsifier, 0-1 part by weight of emollient, 3-7 parts by weight of humectant and 100 parts by weight of deionized water, and stirring at 75-80 ℃ until the raw materials are completely dissolved to obtain the water phase mixture;
C. mixing
Pouring the oil phase mixture obtained in the step A into the water phase mixture obtained in the step B under the condition of stirring, continuously stirring for 2-5 minutes at the stirring speed of 15-25 r/min, and then homogenizing for 6-8 minutes at the homogenizing speed of 8000-12000 r/min and the temperature of 60-70 ℃ to obtain a mixture;
D. charging of
And C, continuously stirring the mixture obtained in the step C for 5-10 min, then reducing the temperature to 45-50 ℃, adding 0.1-0.3 part by weight of thickening agent, 0.2-0.4 part by weight of humectant, 0.1-0.3 part by weight of antioxidant, 0.1-0.5 part by weight of triethanolamine and 0.1-0.3 part by weight of essence, uniformly stirring and mixing, and reducing the temperature to room temperature to obtain the skin-moistening and anti-cracking hand cream.
According to another preferred embodiment of the invention, in step a, the camel fat is prepared according to the following method: adding the minced hump subcutaneous fat into a water boiling tank with a stirring device, wherein the weight ratio of the hump subcutaneous fat to water is 1: boiling in water for 5-6 h for 3-5 h to obtain crude camel peak grease, standing in a boiling tank for oil-water layering, draining off the water phase, adding a 10% NaOH aqueous solution by weight into the oil phase, and neutralizing to pH 7; adding water which is 5 times of the volume of the oil phase, heating at 55-65 ℃ for 35-45 min under stirring, standing for layering, repeating the oil phase for 2-3 times in the same manner, and stirring the powdered activated carbon, the activated clay and the diatomite in a weight ratio of 5: 5: adding powdered activated carbon, activated clay and diatomite into the obtained oil phase, heating for 0.5-l.0 h at the temperature of 60-70 ℃, and centrifuging while the mixture is hot, thus obtaining the camel peak fat.
The present invention will be described in more detail below.
The invention relates to a hump fat hand cream with skin moistening and anti-cracking effects.
The inventor researches and discovers that most unsaturated fatty acids contained in the camel peak fat are long-chain fatty acids (palmitoleic acid), are easily oxidized and rancid, have heavy fishy smell substances, have melting points of about 48 ℃, are in a semisolid solidification state at room temperature, have strong greasy feeling and poor hydrophilicity, and are difficult to directly apply to external application. Therefore, when the hand cream is prepared, the effective emulsifier component is added, the stability of the hand cream is improved through high-speed homogenization, the skin moistening agent is added to promote the hand cream to be better absorbed by the skin, and other skin refreshing components are added to neutralize the greasy feeling of the hand cream, so that the hand cream is capable of moistening the hand skin and is bright and moist. The invention provides a new idea for functional development and utilization of the camel peak fat.
The camel hair fat skin-moistening anti-cracking hand cream comprises the following components: in parts by weight
Deionized water was made up to 100 parts.
The camel peak fat used by the invention is extracted by the following extraction method:
after being slaughtered, healthy adult camels respectively collect fresh, clean and intact camel skin fat, and the fat tissues have no bone, broken skin, viscera, thyroid gland, adrenal gland, lymph node, trachea, crude blood vessel, sinking and clarifying, pressed material and the like, and contain no muscle tissue and blood vessel as far as possible.
The specific extraction method comprises the following steps of adding minced hump subcutaneous fat into a water boiling tank with a stirring device according to the weight ratio of the hump subcutaneous fat to water of 1: boiling in water for 5-6 h for 3-5 h to obtain crude camel peak grease, standing in a boiling tank for oil-water layering, draining off the water phase, adding a 10% NaOH aqueous solution by weight into the oil phase, and neutralizing to pH 7; adding water which is 5 times of the volume of the oil phase, heating at 55-65 ℃ for 35-45 min under stirring, standing for layering, repeating the oil phase for 2-3 times in the same manner, and stirring the powdered activated carbon, the activated clay and the diatomite in a weight ratio of 5: 5: adding powdered activated carbon, activated clay and diatomite into the obtained oil phase, heating for 0.5-l.0 h at the temperature of 60-70 ℃, and centrifuging while the mixture is hot, thus obtaining the camel peak fat. They are colorless and transparent oil-like in color and have no peculiar smell.
In the invention, when other components are in the content range, if the content of the hump fat is less than 4 parts by weight, the prepared hand cream has poor moisturizing effect and moistening effect; if the content of the camel peak fat is higher than 10 parts by weight, the prepared hand cream is too greasy and is not easy to absorb; therefore, it is reasonable that the content of the camel back is 4 to 10 parts by weight, preferably 5 to 8 parts by weight, and more preferably 5 to 6 parts by weight.
In the invention, the lanolin has the basic function of changing the color of the ointment and assisting camel peak fat to achieve better absorption treatment effect, and is an excellent moisturizing substance.
In the present invention, when the other components are within the content range, if the lanolin content is less than 0.1 part by weight, the effect is not significant, and the color of the paste is too light; if the content of lanolin is higher than 3.0 parts by weight, the cost is high and the efficacy of camel's fat cannot be highlighted; accordingly, the lanolin is preferably contained in an amount of 0.1 to 3.0 parts by weight, more preferably 0.8 to 2.6 parts by weight, and still more preferably 1.2 to 2.2 parts by weight.
Lanolin used in the present invention is a product currently marketed, for example, by Spanish Designeous company under the trade name "lanolin".
In the invention, the emulsifier has the basic function of reducing the interfacial surface tension of the emulsion in the oil phase mixture so as to reduce the potential energy of a dispersion system, increase the stability of the paste and be not suitable for water analysis.
The emulsifier used in the present invention is one or more emulsifiers selected from the group consisting of glyceryl monostearate, tween 80 or span 80.
The glyceryl monostearate, tween 80 or span 80 emulsifier is a product currently sold in the market, for example, a product sold under the tradenames "glyceryl monostearate", "tween 80" and "span 80" by the chemical technology ltd.
In the invention, when other components are in the content range, if the content of the emulsifier is less than 2 parts by weight, the camel fat hand cream is unstable, and water and oil are easily separated; if the emulsifier content is more than 6 parts by weight, the cost is high and the method is not economical; therefore, the emulsifier is suitably contained in an amount of 2 to 6 parts by weight, preferably 3 to 5 parts by weight, more preferably 3.8 to 4.2 parts by weight.
In the present invention, the essential function of the emollient is to increase the lubricating properties of the hump fat hand cream.
The emollient used in the present invention is one or more emollients selected from the group consisting of dimethicone, ethylhexylglycerin, cetyl alcohol or jojoba oil.
The dimethicone, ethylhexyl glycerin, cetyl alcohol, or jojoba oil emollients are all currently marketed products, such as dimethicone sold under the trade name "dimethicone" by youson chemical technology co.
In the present invention, when the other components are within the content range, if the emollient content is less than 3 parts by weight, the paste absorption effect is not optimal; if the content of the emollient is higher than 6 parts by weight, the ointment is greasy and airtight, and the cost is high; accordingly, it is appropriate that the emollient is present in an amount of 3 to 6 parts by weight, preferably 3.4 to 5.2 parts by weight, more preferably 4.0 to 4.6 parts by weight.
In the invention, the essential function of the moisturizer in the hump fat hand cream is to help the skin absorb moisture and prevent moisture in the skin from losing.
The moisturizer used in the present invention is one or more moisturizers selected from the group consisting of glycerin, propylene glycol, hyaluronic acid, petrolatum, cetyl alcohol, and vitamin E.
The glycerin, propylene glycol, hyaluronic acid, petrolatum, cetyl alcohol or caprylic/capric triglyceride moisturizer are all products currently marketed, for example, by Qingdao Yosso chemical technology, Inc. under the trade names "hyaluronic acid", "cetyl alcohol", "propylene glycol".
In the invention, when other components are in the content range, if the content of the humectant is less than 4 parts by weight, the camel fat hand cream has no obvious moisturizing effect; if the content of the humectant is higher than 11 parts by weight, the hump fat hand cream is too greasy and has poor air permeability; therefore, it is reasonable that the content of the humectant is 4 to 11 parts by weight, preferably 5.4 to 8.2 parts by weight, more preferably 6 to 7 parts by weight.
In the present invention, the essential role of the preservative in the inventive camel fat hand cream is to render the product microbiologically stable and of sufficient shelf life.
The preservative used in the present invention is one or more preservatives selected from isothiazolinone, phenoxyethanol, methylparaben or propylparaben.
The isothiazolidones, phenoxyethanol, methylparaben, or propylparaben preservatives are currently marketed products, such as those sold under the trade names "isothiazolidones", "phenoxyethanol", "methylparaben", "propylparaben" by youdao chemical technology limited.
In the invention, when other components are in the content range, if the content of the preservative is less than 0.06 part by weight, the anti-corrosion effect of the camel fat hand cream is not obvious; if the content of the preservative is more than 0.15 parts by weight, there is a side effect on the skin; therefore, it is feasible that the content of the preservative is 0.06 to 0.15 parts by weight, preferably 0.08 to 0.12 parts by weight.
In the invention, the thickening agent has the basic function of making the cream body of the hump fat hand cream be pasty liquid.
The thickener used in the present invention is one or more thickeners selected from carbomers, xanthan gum, stearic acid or hydroxyethyl acrylate acrylamide sodium taurate copolymers.
The thickeners described are carbomers, xanthan gum, stearic acid or sodium hydroxyethyl acrylate acrylamide taurate copolymers which are currently marketed, for example, by Qingdao Youso chemical technology, Inc. under the trade designation "carbomer 540".
In the invention, when other components are in the content range, if the content of the thickening agent is less than 0.1 part by weight, the hump fat hand cream is thinner and does not form a paste; if the content of the thickener is higher than 0.3 part by weight, the paste is too thick, cannot spread and has uneven texture; therefore, the thickener is preferably contained in an amount of 0.1 to 0.3 part by weight.
The essence used in the invention is papaya essence or lavender essence. They are all products currently marketed, for example, by Qingdao Youso chemical technology, Inc. under the trade names "papaya essence" and "lavender essence".
The amount of essence used in the invention is 0.1-0.3 parts by weight, and obviously, too much or too little essence is not favorable.
In the invention, the basic functions of the antioxidant in the hump fat hand cream are to eliminate free radicals in vivo and reduce the damage of ultraviolet rays to human bodies.
The antioxidant used in the present invention is tocopherol acetate, which is a product currently marketed, for example, by the Qingdao Yosso chemical technology Co., Ltd under the trade name "tocopherol acetate".
In the invention, when other components are in the content range, if the content of the antioxidant is less than 0.1 part by weight, the oxidation resistance of the camel fat hand cream is poor; if the antioxidant content is more than 0.3 parts by weight, unnecessary waste may be caused; therefore, the antioxidant is preferably contained in an amount of 0.1 to 0.3 parts by weight.
In the present invention, the essential role of triethanolamine in the inventive camel hair cream is to adjust the pH of the hand cream.
The triethanolamine used in the present invention is a product currently marketed, for example, by Yousso chemical Co., Ltd. in Qingdao under the trade name "triethanolamine".
In the invention, when other components are in the content range, if the content of triethanolamine is less than 0.1 part by weight, the pH value of the hump fat hand cream is larger; if the content of the antioxidant is higher than 0.3 part by weight, the pH value of the hump fat hand cream is too small; therefore, an antioxidant content of 0.1 to 0.3 parts by weight is feasible, preferably 0.13 to 0.18.
The invention also relates to a preparation method of the skin-moistening anti-cracking hand cream.
The preparation method comprises the following steps:
A. preparing an oil phase mixture:
mixing 4-10 parts by weight of camel hair fat, 0.1-3.0 parts by weight of lanolin, 1-3 parts by weight of emulsifier, 2-5 parts by weight of emollient, 0-4 parts by weight of humectant and 0.06-0.15 part by weight of preservative, and stirring at 75-80 ℃ until the raw materials are completely dissolved;
B. preparation of an aqueous mixture
Mixing 1-3 parts by weight of emulsifier, 0-1 part by weight of emollient, 3-7 parts by weight of humectant and 100 parts by weight of deionized water, and stirring at 75-80 ℃ until the raw materials are completely dissolved;
C. mixing
Pouring the oil phase mixture obtained in the step A into the water phase mixture obtained in the step B under the condition of stirring, continuously stirring for 2-5 minutes at the stirring speed of 15-25 r/min, and then homogenizing for 6-8 minutes at the homogenizing speed of 8000-12000 r/min and the temperature of 60-70 ℃ to obtain a mixture;
D. charging of
And C, continuously stirring the mixture obtained in the step C for 5-l 0min, then reducing the temperature to 45-50 ℃, adding 0.1-0.3 part by weight of thickening agent, 0.2-0.4 part by weight of humectant, 0.1-0.3 part by weight of antioxidant, 0.1-0.3 part by weight of triethanolamine and 0.1-0.3 part by weight of essence, uniformly stirring and mixing, and reducing the temperature to room temperature to obtain the skin-moistening and anti-cracking hand cream.
The conditions of camel fat, lanolin, emulsifier, emollient, humectant, preservative, triethanolamine, antioxidant, thickener and perfume have been described above and will not be described further herein.
The equipment used for preparing the skin-moistening anti-cracking hand cream is equipment which is commonly used in the technical field and sold in the market at present.
The application method of the skin-moistening anti-cracking hand cream is that after hands are cleaned with clear water, a proper amount of the skin-moistening anti-cracking hand cream is smeared on the back of the hands and is rubbed and permeated.
[ advantageous effects ]
The invention has the beneficial effects that:
the camel hair fat moisturizing and anti-cracking hand cream disclosed by the invention is fresh and comfortable after use, good in stability, fresh and comfortable in smell, glossy and moist in skin after being smeared, very fine and smooth, and has good moisturizing and moisturizing effects and the like. The skin moistening and anti-cracking hand cream disclosed by the invention has the advantages of obvious moistening and moisturizing effects, fresh and cool skin feeling without greasiness, and simultaneously has a good effect of brightening skin color. The skin-moistening anti-cracking hand cream disclosed by the invention is stable in preparation process, the cream is yellowish and bright in color, fine and smooth in texture and free of stimulation to skin, and the good effects of moistening and caring skin are achieved.
[ description of the drawings ]
FIG. 1 is a graph of the cumulative permeation quantity of hump oil in the skin moistening and anti-cracking hand cream through in vitro skin, which changes along with time.
FIG. 2 is a photograph of ear dermatitis sections from Balb/c mice.
[ detailed description ] embodiments
The invention will be better understood from the following examples.
Example 1: the skin-moistening anti-cracking hand cream is prepared
The implementation steps of this example are as follows:
A. preparation of an oil phase mixture
Mixing 8 parts by weight of camel oil, 1.5 parts by weight of lanolin, 2.0 parts by weight of glyceryl monostearate emulsifier, 2.8 parts by weight of polydimethylsiloxane emollient, 3.0 parts by weight of glycerin humectant and 0.08 part by weight of isothiazolinone preservative, and stirring at 75 ℃ until the raw materials are completely dissolved to obtain the oil phase mixture;
the camel hair fat is prepared by the following steps:
adding the minced hump subcutaneous fat into a water boiling tank with a stirring device, wherein the weight ratio of the hump subcutaneous fat to water is 1: boiling in water for 6h to obtain crude camel peak fat, standing in a boiling tank for oil-water stratification, draining off the water phase, adding 10% by weight NaOH aqueous solution into the oil phase, and neutralizing to pH 7; then adding water 5 times the volume of the oil phase, heating at 55 deg.C under stirring for 35min, standing for layering, repeating the oil phase for 2 times in the same manner, and stirring powdered activated carbon, activated clay and diatomite at a weight ratio of 5: 5: 1, adding powdered activated carbon, activated clay and diatomite into the obtained oil phase, heating for l.0h at the temperature of 60 ℃, and centrifuging and separating while hot to obtain the camel peak fat;
B. preparation of an aqueous mixture
Mixing 2.0 parts by weight of glyceryl monostearate emulsifier, 0.5 part by weight of polydimethylsiloxane emollient, 4 parts by weight of glycerin humectant and 100 parts by weight of deionized water, and stirring at 75 ℃ until the raw materials are completely dissolved to obtain the water phase mixture;
C. mixing
Pouring the oil phase mixture obtained in step A into the aqueous phase mixture obtained in step B with stirring, and stirring at a stirring speed of 15r/min for 2 minutes, followed by homogenization for 6 minutes at a homogenization speed of 10000r/min and a temperature of 60 ℃ using a homogenizer sold under the trade name FLUKO Frouk by Shanghai Frouk fluid machines manufacturing Co., Ltd, to obtain a mixture;
D. charging of
And C, continuously stirring the mixture obtained in the step C for 5min, then reducing the temperature to 45 ℃, adding 0.1 part by weight of carbomer thickening agent, 0.3 part by weight of glycerin humectant, 0.2 part by weight of tocopherol acetate antioxidant, 0.4 part by weight of triethanolamine and 0.1 part by weight of papaya essence, stirring and mixing uniformly, and reducing the temperature to room temperature to obtain the skin-moistening and anti-cracking hand cream.
In the example, the results of in vitro transdermal test, mouse ear dermatitis section test, physical and chemical index test and skin feel test of the skin moisturizing and anti-cracking hand cream prepared by the method are shown in the following test examples.
Example 2: the skin-moistening anti-cracking hand cream is prepared
The implementation steps of this example are as follows:
A. preparation of an oil phase mixture
Mixing 4 parts by weight of camel oil, 0.8 part by weight of lanolin, 2.5 parts by weight of an emulsifier (1 part by weight of glyceryl monostearate +0.7 part by weight of tween 80+0.8 part by weight of span 80), 3.6 parts by weight of an emollient (0.8 part by weight of dimethicone +0.4 part by weight of ethylhexylglycerin +0.6 part by weight of cetyl alcohol +1.8 parts by weight of jojoba oil), 3.6 parts by weight of a humectant (1.0 part by weight of glycerin +1.2 part by weight of propylene glycol +0.4 part by weight of hyaluronic acid +0.6 part by weight of petrolatum +0.4 part by weight of caprylic/capric triglyceride), and 0.10 parts by weight of a preservative (0.2 part by weight of isothiazolinone +0.1 part by weight of phenoxyethanol +0.3 part by weight of methylparaben +0.4 part by weight of propylparaben), stirring at a temperature of 78 ℃ until these raw materials are completely dissolved to obtain said oil phase mixture;
the camel hair fat is prepared by the method described in the example 1, and only the ground camel hair subcutaneous fat is added according to the weight ratio of the ground camel hair subcutaneous fat to water of 1: 4 boiling in water for 5.5 h; heating the oil phase with water at 60 deg.C under stirring for 45 min; adding powdered activated carbon, activated clay and diatomite into the oil phase, and heating at 65 ℃ for 0.5 h;
B. preparation of an aqueous mixture
Mixing 2.5 parts by weight of an emulsifier (1.2 parts by weight of glyceryl monostearate +0.5 part by weight of tween 80+0.8 part by weight of span 80), 0 part by weight of an emollient, 7 parts by weight of a humectant (1 part by weight of glycerin +0.5 part by weight of propylene glycol +0.8 part by weight of hyaluronic acid +4 parts by weight of petrolatum +0.7 part by weight of caprylic/capric triglyceride) with deionized water supplemented to 100 parts by weight, and stirring at a temperature of 78 ℃ until all the raw materials are dissolved to obtain the aqueous phase mixture;
C. mixing
Pouring the oil phase mixture obtained in step A into the aqueous phase mixture obtained in step B with stirring, and stirring at a stirring speed of 20r/min for 5 minutes, followed by homogenizing for 8 minutes at a homogenizing speed of 8000r/min and a temperature of 65 ℃ using a homogenizer sold under the trade name FLUKO Frouk by Shanghai Frouk fluid machines, Ltd, to obtain a mixture;
D. charging of
And C, continuously stirring the mixture obtained in the step C for 6min, then reducing the temperature to 48 ℃, adding 0.3 part by weight of a thickening agent (0.1 part by weight of carbomer +0.1 part by weight of xanthan gum +0.05 part by weight of stearic acid +0.05 part by weight of hydroxyethyl acrylate acrylamide sodium taurate copolymer), 0.4 part by weight of a humectant (0.1 part by weight of glycerol +0.1 part by weight of propylene glycol +0.06 part by weight of hyaluronic acid +0.1 part by weight of vaseline +0.04 part by weight of caprylic/capric triglyceride), 0.3 part by weight of antioxidant tocopheryl acetate, 0.2 part by weight of triethanolamine and 0.2 part by weight of essence (0.1 part by weight of papaya essence +0.1 part by weight of lavender essence), stirring and mixing uniformly, and reducing the temperature to room temperature to obtain the skin moisturizing and anti-cracking hand cream.
In the example, the results of in vitro transdermal test, mouse ear dermatitis section test, physical and chemical index test and skin feel test of the skin moisturizing and anti-cracking hand cream prepared by the method are shown in the following test examples.
Example 3: the skin-moistening anti-cracking hand cream is prepared
The implementation steps of this example are as follows:
A. preparation of an oil phase mixture
Mixing 10 parts by weight of camel oil, 0.1 part by weight of lanolin, 1.0 part by weight of an emulsifier (0.2 part by weight of glyceryl monostearate +0.5 part by weight of tween 80+0.3 part by weight of span 80), 2.0 parts by weight of an emollient (0.5 part by weight of polydimethylsiloxane +0.8 part by weight of ethylhexylglycerin +0.7 part by weight of cetyl alcohol), 0.8 parts by weight of a humectant (0.2 part by weight of propylene glycol +0.3 part by weight of hyaluronic acid +0.3 part by weight of petrolatum) and 0.06 part by weight of a preservative (0.2 part by weight of phenoxyethanol +0.2 part by weight of methylparaben +0.2 part by weight of propylparaben), stirring at a temperature of 80 ℃ until these raw materials are completely dissolved to obtain the oil phase mixture;
wherein, the hump fat is prepared according to the method described in the example 1, and only the ground hump subcutaneous fat is added according to the weight ratio of the hump subcutaneous fat to the water of 1: 5 boiling in water for 5.0 h; heating the oil phase with water at 65 deg.C under stirring for 38 min; adding powdered activated carbon, activated clay and diatomite into the oil phase, and heating at 68 ℃ for 0.6 h;
B. preparation of an aqueous mixture
Mixing 1.0 part by weight of an emulsifier (0.4 part by weight of glyceryl monostearate +0.4 part by weight of tween 80 and 0.2 part by weight of span 80), 0.8 part by weight of an emollient (0.2 part by weight of polydimethylsiloxane +0.2 part by weight of cetyl alcohol +0.4 part by weight of jojoba oil), 3 parts by weight of a humectant (1.2 parts by weight of propylene glycol +1 part by weight of hyaluronic acid +0.8 part by weight of caprylic/capric triglyceride) and 100 parts by weight of deionized water, stirring at 80 ℃ until all the raw materials are dissolved to obtain the aqueous phase mixture;
C. mixing
Pouring the oil phase mixture obtained in step A into the aqueous phase mixture obtained in step B with stirring, and stirring at a stirring speed of 25r/min for 3 minutes, followed by homogenization for 7 minutes at a homogenization speed of 12000r/min and a temperature of 68 ℃ using a homogenizer sold under the trade name FLUKO Frouk by Shanghai Frouk fluid machines manufacturing Ltd;
D. charging of
And C, continuously stirring the mixture obtained in the step C for 8min, then reducing the temperature to 50 ℃, adding 0.2 part by weight of thickening agent (0.1 part by weight of carbomer +0.05 part by weight of xanthan gum +0.05 part by weight of stearic acid), 0.2 part by weight of humectant (0.1 part by weight of glycerol +0.05 part by weight of propylene glycol +0.05 part by weight of hyaluronic acid), 0.1 part by weight of antioxidant tocopherol acetate, 0.1 part by weight of triethanolamine and 0.3 part by weight of essence (0.2 part by weight of papaya essence +0.1 part by weight of lavender essence), stirring and uniformly mixing, and reducing the temperature to room temperature to obtain the skin-moistening and anti-cracking hand cream.
In the example, the results of in vitro transdermal test, mouse ear dermatitis section test, physical and chemical index test and skin feel test of the skin moisturizing and anti-cracking hand cream prepared by the method are shown in the following test examples.
Example 4: the skin-moistening anti-cracking hand cream is prepared
The implementation steps of this example are as follows:
A. preparation of an oil phase mixture
Mixing 6 parts by weight of camel oil, 3.0 parts by weight of lanolin, 1.5 parts by weight of emulsifier (0.2 part by weight of glyceryl monostearate +0.8 part by weight of tween 80+0.5 part by weight of span 80), 4.2 parts by weight of emollient (1.2 parts by weight of dimethicone +0.8 part by weight of ethylhexyl glycerin +0.6 part by weight of cetyl alcohol +1.6 parts by weight of jojoba oil), 1.5 parts by weight of humectant (0.4 part by weight of propylene glycol +0.2 part by weight of hyaluronic acid +0.6 part by weight of petrolatum +0.3 part by weight of caprylic/capric triglyceride) and 0.15 parts by weight of preservative (0.4 part by weight of isothiazolinone +0.5 part by weight of phenoxyethanol +0.4 part by weight of methyl hydroxybenzoate +0.2 part by weight of propyl hydroxybenzoate), stirring at a temperature of 76 ℃ until all of these raw materials are dissolved to give said oil phase mixture;
wherein, the hump fat is prepared according to the method described in the example 1, and only the ground hump subcutaneous fat is added according to the weight ratio of the hump subcutaneous fat to the water of 1: 4 boiling in water for 5.5 h; heating the oil phase with water at 58 deg.C under stirring for 40 min; adding powdered activated carbon, activated clay and diatomite into the oil phase, and heating at 70 ℃ for 0.8 h;
B. preparation of an aqueous mixture
Mixing 1.5 parts by weight of an emulsifier (0.8 part by weight of glyceryl monostearate +0.2 part by weight of tween 80+0.5 part by weight of span 80), 0.8 part by weight of an emollient (0.2 part by weight of polydimethylsiloxane +0.2 part by weight of ethylhexylglycerin +0.2 part by weight of cetyl alcohol +0.2 part by weight of jojoba oil), 5 parts by weight of a humectant (1.4 parts by weight of glycerin +1.6 parts by weight of propylene glycol +1.0 part by weight of hyaluronic acid +1.0 part by weight of petrolatum) with deionized water supplemented to 100 parts by weight, stirring at a temperature of 75 ℃ until all the raw materials are dissolved to obtain the aqueous phase mixture;
C. mixing
Pouring the oil phase mixture obtained in step A into the aqueous phase mixture obtained in step B with stirring, and stirring at a stirring speed of 20r/min for 4 minutes, followed by homogenization for 8 minutes at a homogenization speed of 11000r/min and a temperature of 70 ℃ using a homogenizer sold under the trade name FLUKO Frank by Shanghai Frank fluid machines Ltd, to obtain a mixture;
D. charging of
And C, continuously stirring the mixture obtained in the step C for 7min, then reducing the temperature to 48 ℃, adding 0.2 part by weight of a thickening agent (0.05 part by weight of carbomer +0.05 part by weight of xanthan gum +0.05 part by weight of stearic acid +0.05 part by weight of hydroxyethyl acrylate acrylamide sodium taurate copolymer), 0.3 part by weight of a humectant (0.05 part by weight of glycerol +0.05 part by weight of propylene glycol +0.12 part by weight of hyaluronic acid +0.08 part by weight of caprylic/capric triglyceride), 0.3 part by weight of antioxidant tocopheryl acetate, 0.5 part by weight of triethanolamine and 0.2 part by weight of essence (0.1 part by weight of papaya essence +0.1 part by weight of lavender essence), stirring and uniformly mixing, and reducing the temperature to room temperature to obtain the skin-moistening and anti-cracking hand cream.
In the example, the results of in vitro transdermal test, mouse ear dermatitis section test, physical and chemical index test and skin feel test of the skin moisturizing and anti-cracking hand cream prepared by the method are shown in the following test examples.
Example 5: the skin-moistening anti-cracking hand cream is prepared
The implementation steps of this example are as follows:
A. preparation of an oil phase mixture
Mixing 5 parts by weight of camel oil, 2.2 parts by weight of lanolin, 3.0 parts by weight of an emulsifier (2.0 parts by weight of glyceryl monostearate +1.0 part by weight of span 80), 5.0 parts by weight of an emollient (1.8 parts by weight of ethylhexyl glycerin +3.2 parts by weight of jojoba oil), 2.2 parts by weight of a humectant (1.6 parts by weight of hyaluronic acid +0.6 part by weight of caprylic/capric triglyceride), and 0.12 parts by weight of a preservative (0.5 part by weight of phenoxyethanol +0.7 part by weight of propylparaben), and stirring at 78 ℃ until all the raw materials are dissolved to obtain the oil phase mixture;
wherein, the hump fat is prepared according to the method described in the example 1, and only the ground hump subcutaneous fat is added according to the weight ratio of the hump subcutaneous fat to the water of 1: 5 boiling in water for 5.0 h; heating the oil phase with water at 62 deg.C under stirring for 42 min; adding powdered activated carbon, activated clay and diatomite into the oil phase, and heating at 63 ℃ for 0.9 h;
B. preparation of an aqueous mixture
Mixing 3.0 parts by weight of an emulsifier (2.0 parts by weight of glyceryl monostearate +1.0 part by weight of span 80), 1.0 part by weight of an emollient (0.4 parts by weight of ethylhexyl glycerin +0.6 part by weight of jojoba oil), 6 parts by weight of a humectant (2.2 parts by weight of hyaluronic acid +3.8 parts by weight of caprylic/capric triglyceride), and deionized water supplemented to 100 parts by weight, and stirring at 78 ℃ until all the raw materials are dissolved to obtain the aqueous phase mixture;
C. mixing
Pouring the oil phase mixture obtained in step A into the aqueous phase mixture obtained in step B with stirring, and stirring at a stirring speed of 18r/min for 3 minutes, followed by homogenization for 6 minutes at a homogenization speed of 10000r/min and a temperature of 63 ℃ using a homogenizer sold under the trade name FLUKO Frouk by Shanghai Frouk fluid machines manufacturing Co., Ltd, to obtain a mixture;
D. charging of
And C, continuously stirring the mixture obtained in the step C for 10min, then reducing the temperature to 48 ℃, adding 0.1 part by weight of thickening agent (0.04 part by weight of stearic acid and 0.06 part by weight of hydroxyethyl acrylate acrylamide sodium taurate copolymer), 0.2 part by weight of humectant (0.08 part by weight of hyaluronic acid and 0.12 part by weight of caprylic/capric triglyceride), 0.2 part by weight of antioxidant tocopheryl acetate, 0.3 part by weight of triethanolamine and 0.2 part by weight of essence (0.1 part by weight of papaya essence and 0.1 part by weight of lavender essence), stirring and uniformly mixing, and reducing the temperature to room temperature to obtain the skin moisturizing and anti-cracking hand cream.
In the example, the results of in vitro transdermal test, mouse ear dermatitis section test, physical and chemical index test and skin feel test of the skin moisturizing and anti-cracking hand cream prepared by the method are shown in the following test examples.
Test example 1: in-vitro transdermal test of hump oil in skin moistening and anti-cracking hand cream
The in vitro transdermal test set test group, blank control group, lanolin, horse oil and azone positive control group, wherein lanolin is sold under the trade name "lanolin" by Qingdao Youso chemical technology Co., Ltd, horse oil is sold under the trade name "horse oil" by Hoheohastemi Zelkova Biotech Limited, and azone is sold under the trade name "azone" by Qingdao Youso chemical technology Co., Ltd.
Test groups the test methods were as follows:
the method for obtaining the receiving liquid comprises the following steps: fixing rat skin with a proper size between a drug supply pool and a receiving pool by using an intelligent transdermal machine, enabling one side of the dermis to be in contact with receiving liquid (normal hexane) to exhaust bubbles, enabling a horny layer to face the drug supply pool, adding grease to be detected into the drug supply pool, starting an electromagnetic constant-temperature stirrer, setting the water bath temperature to be 36.5 ℃, simulating the normal human body temperature, exhausting bubbles in the receiving pool, enabling the receiving liquid to be in contact with the skin, recording the starting time, accurately sucking 3mL of the receiving liquid when 2, 4, 6, 8 and 10 hours respectively, and simultaneously supplementing the receiving liquid with the same volume;
measuring by an ultraviolet spectrophotometry, namely measuring the absorbance of a receiving solution under a fixed wavelength by using an enzyme-labeling instrument at normal temperature to calculate the content of the hump oil in the receiving solution, wherein the calculation formula is a linear equation obtained by linearly regressing the absorbance by the concentration of the hump oil;
when the skin-moistening anti-cracking hand cream is applied for 2, 4, 6, 8 and 10 hours, the absorbance of the hump oil in the receiving liquid is measured by adopting an ultraviolet spectrophotometry according to Qn＝(CnVGeneral assembly+∑Cn-1VGet) The formula isAnd (3) calculating the accumulated permeation quantity and the permeation rate by using a hump oil absorptiometer, simultaneously performing tissue homogenization on the rat skin at the 10 th hour by using a tissue homogenizer, and performing ultrasonic extraction for 30min at normal temperature by using an n-hexane solvent. The obtained extract is measured by the ultraviolet spectrophotometry to obtain the content of hump oil in the extract, namely the retention amount in the skin at 10 h.
The test results of the test group, the blank control group, the lanolin, the horse oil and the azone positive control group are shown in the attached figure 1, the table 1 and the table 2.
Table 1: osmotic equation and osmotic rate of different oils and azones
From the results of FIG. 1 and Table 1, it can be seen that the initial permeation rates of the four substances are low, mainly because the substances need to completely permeate the rat skin to form a permeation pathway. The cumulative permeation amount of the hump oil is slightly higher than that of the horse oil in 0-4 h, the cumulative permeation amount of the hump oil is basically equal to that of the horse oil in 6-8 h, and the cumulative permeation amount of the hump oil is slightly lower than that of the horse oil in 8-10 h. The total amount of the natural hump oil and the horse oil is similar to the accumulated permeation amount within 10h and is much higher than that of lanolin, and the accumulated permeation amount is 19 times of that of the lanolin; according to the Q-T equation, the permeation rate of the natural camel oil is similar to that of horse oil and is 22 times of that of lanolin.
TABLE 2 skin retention at 10 hours for different oils and ketones
Note: a shows that the difference of the skin retention of each group of the same oil is not obvious, b shows that the difference of the skin retention of each group of the same oil is obvious; the same capital letters indicate no significant difference between groups, and different capital letters indicate significant difference between groups.
The skin retention (attached table 2) is subjected to significance analysis (P <0.05), and then the azone group is found to have significant difference with the hump oil group, the horse oil group and the lanolin group; the difference between the hump oil group and the horse oil group is not obvious, and the difference between the hump oil group and the lanolin group is obvious; the difference between the horse oil group and the lanolin group is significant. Skin retentate is ultimately absorbed by the skin and therefore skin retention is an important indicator of skin absorption. Azone as positive control, with skin retention 3.2 times of natural hump oil, 2.9 times of horse oil, and 6.9 times of lanolin; the skin retention of hump oil and horse oil is similar to that of lanolin and is 2 times as high as that of lanolin.
Test example 2 Balb/c mouse ear dermatitis slice test of the skin moisturizing and anti-cracking hand cream
In order to verify that the skin-moistening anti-cracking hand cream has the effects of diminishing inflammation, cracking and the like, the hand cream is applied to the ear of a Balb/c mouse suffering from chronic dermatitis twice a day, the application amount is the same for each time, the hand cream is applied for 20 days, and the action effect and the pathological change of the skin tissue of the ear of the mouse are observed.
The test is provided with a normal group, a model building group and a treatment group. The normal group is the mice without molding and treatment groups, the molding group is the mice suffering from chronic dermatitis without any treatment group, the treatment group is the mice suffering from chronic dermatitis coated with the skin moistening and anti-cracking hand cream and the vaseline group, and the obtained results are shown in the attached figure 2.
As can be seen from the attached figure 2, the ear skin histology of the normal mice is clear, the layers are distinct, the epidermis thickness is normal, no edema exists in cells and between cells, and no obvious lymphocyte infiltration exists. After modeling, the mouse ear epidermis is thickened, and intracellular and intercellular edema and a large amount of lymphocyte infiltration in the dermis superficial layer can be seen. The skin-moistening anti-cracking hand cream has the advantages that the thickening degree of the epidermis of the ear tissue is reduced, and the edema of the epidermis and the dermis of a mouse treated by the hand cream is obviously relieved.
Test example 3: physical and chemical index inspection
This test example carried out the following tests:
1. trait detection
The skin-moistening anti-cracking hand cream disclosed by the invention is light yellow, moderate in viscosity and hardness, fine and uniform in cream body, good in spreadability, cool and comfortable after use, not greasy, good in stability, and fresh and comfortable in smell.
2. Cold and hot test
The skin-moistening anti-cracking hand cream is sealed in a transparent cosmetic bottle and is refrigerated in a refrigerator at the temperature of-15 ℃ for 24 hours, and no layering phenomenon is observed. The skin-moistening anti-cracking hand cream has no phenomena of layering, emulsification, off-flavor and the like in a constant temperature box at the temperature of 45 ℃ for 24 hours.
3. Centrifugal test
The skin-moistening anti-cracking hand cream disclosed by the invention is packaged in a centrifugal tube, and is centrifuged for 30min at a rotating speed of 3000r/min, so that no layering phenomenon is found.
4. Stability test
The skin-moistening anti-cracking hand cream is placed in a cosmetic bottle, is kept stand at room temperature for 1 month, has no layering phenomenon, and has no change in feeling and no change in smell after use.
5. Irritation test and allergy test
The back of the test white mouse is cut off, and the skin-moistening anti-cracking hand cream prepared in example 3 is respectively applied to the cut-off part, and meanwhile, the same hand cream is also applied to the part without cut-off hair for comparison. After being applied for 30min, no irritation and anaphylaxis such as redness, rash, blister, etc. appear on the sheared part and the part without shearing hair.
Meanwhile, 1g of the four skin-moistening anti-cracking hand creams prepared in the above examples 2-5 are smeared on the hand surface of a volunteer, and no redness, rash, bubbling and the like are observed after 30min of smearing.
Test example 4: skin feel test
The trial feeling is utilized to evaluate the efficacy of the skin moistening and anti-cracking hand cream after being smeared for 30 min. 30 people of 20-60 years old are selected as trial objects by adopting a civil survey grading method, the trial objects are randomly divided into five groups, and the skin moistening and anti-cracking hand cream prepared in the embodiment 1-5 is respectively smeared on the dry crack and desquamation part of the hand.
The application method comprises the following steps: the application method comprises the steps of smearing the back of a hand of a trial subject for 3 times, 1 g/time, 4 hours every time, keeping for 1-2 minutes after each smearing, and applying for one month in such a way.
Moisture retention scoring criteria: after the skin moistening and anti-cracking hand cream is used, the skin is not moist and tight;
standard of freshness score: after the skin moistening and anti-cracking hand cream is used, the skin feel is cool and not greasy;
spreadability scoring criteria: after the skin moistening and anti-cracking hand cream is used, the skin moistening and anti-cracking hand cream is easy to apply and is not whitened;
the fineness scoring standard is as follows: after the skin moistening and anti-cracking hand cream is used, the cream is fine and smooth and does not cake;
absorption effect scoring criteria: the skin-moistening anti-cracking hand cream is easy to absorb and good in maintenance effect;
glossiness scoring standard: the skin-moistening anti-cracking hand cream has better brightness;
the using effects of the ingredients are divided into 5 points: 5 is the highest score, which means good and satisfactory; 4, the division is better; 3 is acceptable; when the amount is less than 3 points, the results are not acceptable.
The average score results are shown in table 3.
Table 3: skin feel test results
The results in table 3 show that the skin moistening and anti-cracking hand cream can moisten hand skin, keep moisture for a long time and effectively improve the skin chapping condition.
In conclusion, the skin moistening and anti-cracking hand cream disclosed by the invention is green and healthy, attractive in appearance, appropriate in viscosity, fine and uniform in cream body, good in spreadability, glossy and moist in skin after being applied, very fine and fine, and has good effects of moistening and moisturizing and the like. The skin-moistening anti-cracking hand cream disclosed by the invention is good in permeability, large in skin retention, capable of being effectively absorbed by skin, and has the effects of diminishing inflammation and cracking.
Claims (6)
1. A hump fat hand cream with skin moistening and anti-cracking effects is characterized by comprising the following components: in parts by weight
The humectant is one or more humectants selected from glycerol, hyaluronic acid or caprylic/capric triglyceride; the emulsifier is one or more emulsifiers selected from glyceryl monostearate, tween 80 or span 80; the emollient is one or more selected from ethylhexyl glycerin, cetyl alcohol, or jojoba oil.
2. The hump fat hand cream according to claim 1, characterized in that said thickener is one or more thickeners selected from carbomers, xanthan gum, stearic acid or sodium hydroxyethyl acrylate acrylamide taurate copolymer.
3. The hump fat hand cream according to claim 1, characterized in that the preservative is one or more preservatives selected from isothiazolidones or phenoxyethanol.
4. The hand cream as claimed in claim 1, characterized in that the essence is papaya essence or lavender essence.
5. The hand cream according to claim 1, characterized in that said antioxidant is tocopherol acetate.
6. The preparation method of the hump fat hand cream according to any one of claims 1 to 5, characterized by comprising the following steps:
A. preparation of an oil phase mixture
Mixing 4-10 parts by weight of camel oil, 0.1-3.0 parts by weight of lanolin, 1-3 parts by weight of emulsifier, 2-5 parts by weight of emollient, 0.8-3.6 parts by weight of humectant and 0.06-0.15 part by weight of preservative, and stirring at 75-80 ℃ until the raw materials are completely dissolved to obtain the oil phase mixture;
the camel peak fat is prepared according to the following method:
adding the minced hump subcutaneous fat into a water boiling tank with a stirring device, wherein the weight ratio of the hump subcutaneous fat to water is 1: boiling in water for 5-6 h for 3-5 h to obtain crude camel peak grease, standing in a boiling tank for oil-water layering, draining off the water phase, adding a 10% NaOH aqueous solution by weight into the oil phase, and neutralizing to pH 7; adding water which is 5 times of the volume of the oil phase, heating at 55-65 ℃ for 35-45 min under stirring, standing for layering, repeating the oil phase for 2-3 times in the same manner, and stirring the powdered activated carbon, the activated clay and the diatomite in a weight ratio of 5: 5: 1, adding powdered activated carbon, activated clay and diatomite into the obtained oil phase, heating for 0.5-l.0 h at the temperature of 60-70 ℃, and centrifuging and separating while the oil phase is hot to obtain the camel peak fat;
B. preparation of an aqueous mixture
Mixing 1-3 parts by weight of emulsifier, 0-1 part by weight of emollient, 3-7 parts by weight of humectant and 100 parts by weight of deionized water, and stirring at 75-80 ℃ until the raw materials are completely dissolved to obtain the water phase mixture;
C. mixing
Pouring the oil phase mixture obtained in the step A into the water phase mixture obtained in the step B under the condition of stirring, continuously stirring for 2-5 minutes at the stirring speed of 15-25 r/min, and then homogenizing for 6-8 minutes at the homogenizing speed of 8000-12000 r/min and the temperature of 60-70 ℃ to obtain a mixture;
D. charging of
And C, continuously stirring the mixture obtained in the step C for 5-10 min, then reducing the temperature to 45-50 ℃, adding 0.1-0.3 part by weight of thickening agent, 0.2-0.4 part by weight of humectant, 0.1-0.3 part by weight of antioxidant, 0.1-0.5 part by weight of triethanolamine and 0.1-0.3 part by weight of essence, uniformly stirring and mixing, and reducing the temperature to room temperature to obtain the skin-moistening and anti-cracking hand cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810561313.2A CN108434021B (en) | 2018-06-04 | 2018-06-04 | Hump fat hand cream with skin moistening and anti-cracking effects and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810561313.2A CN108434021B (en) | 2018-06-04 | 2018-06-04 | Hump fat hand cream with skin moistening and anti-cracking effects and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108434021A CN108434021A (en) | 2018-08-24 |
| CN108434021B true CN108434021B (en) | 2020-03-31 |
Family
ID=63206606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810561313.2A Active CN108434021B (en) | 2018-06-04 | 2018-06-04 | Hump fat hand cream with skin moistening and anti-cracking effects and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108434021B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110664686A (en) * | 2019-10-30 | 2020-01-10 | 贵州理工学院 | Water shield skin moistening and anti-cracking hand cream and preparation method thereof |
| CN110731933A (en) * | 2019-11-25 | 2020-01-31 | 肤能生物科技(洛阳)有限公司 | allergy-relieving, moisturizing and anti-aging hand cream containing peony whole plant extract and preparation method thereof |
| CN115300408A (en) * | 2022-08-31 | 2022-11-08 | 仲恺农业工程学院 | Skin moisturizing composition, hand cream and preparation method thereof |
| CN116035957A (en) * | 2023-02-16 | 2023-05-02 | 塔里木大学 | Method for preparing clean moisturizing facial mask by using vermiculite and camel hump as raw materials |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585073A (en) * | 2013-11-28 | 2014-02-19 | 骆琦 | Hand cream capable of warming hand and preparation method |
| CN104586650A (en) * | 2013-10-31 | 2015-05-06 | 马文 | Anti-chapping hand cream |
| CN105832587A (en) * | 2016-03-24 | 2016-08-10 | 攀柔莎（江苏）生物科技股份有限公司 | Plant extraction essence hand cream |
| CN105853288A (en) * | 2016-05-05 | 2016-08-17 | 广州丹奇日用化工厂有限公司 | Hand cream for preventing hangnails of children |
| CN106137911A (en) * | 2016-07-28 | 2016-11-23 | 扬中市锦丰工业设计有限公司 | Anticracking hand cream |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130011451A1 (en) * | 2011-07-06 | 2013-01-10 | Diversified Glogal Technologies, Llc | Footbed with non-denatured collagen |
| US9889084B2 (en) * | 2014-01-10 | 2018-02-13 | Valicor, Inc. | Compositions of cosmetic, personal care and skin care products derived from lipid feedstocks and methods to produce the same |
-
2018
- 2018-06-04 CN CN201810561313.2A patent/CN108434021B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586650A (en) * | 2013-10-31 | 2015-05-06 | 马文 | Anti-chapping hand cream |
| CN103585073A (en) * | 2013-11-28 | 2014-02-19 | 骆琦 | Hand cream capable of warming hand and preparation method |
| CN105832587A (en) * | 2016-03-24 | 2016-08-10 | 攀柔莎（江苏）生物科技股份有限公司 | Plant extraction essence hand cream |
| CN105853288A (en) * | 2016-05-05 | 2016-08-17 | 广州丹奇日用化工厂有限公司 | Hand cream for preventing hangnails of children |
| CN106137911A (en) * | 2016-07-28 | 2016-11-23 | 扬中市锦丰工业设计有限公司 | Anticracking hand cream |
Non-Patent Citations (1)
| Title |
|---|
| 以双峰驼乳、驼峰为原料的美容产品发展现状;苏雪等;《第四届（2015）中国骆驼大会》;20150907;第1页引言部分 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108434021A (en) | 2018-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108434021B (en) | Hump fat hand cream with skin moistening and anti-cracking effects and preparation method thereof | |
| CN109157450B (en) | Acne-removing essence | |
| CN105943491A (en) | Moistening and moisturizing essence and preparation method thereof | |
| CN112618456B (en) | Oil control convergence suit and use method thereof | |
| CN103989601B (en) | A kind of shining tender skin face cream of face moisturizing and preparation method thereof | |
| CN103622886B (en) | There is the skin care compositions of acne-removing, preparation and preparation method thereof | |
| FR2725370A1 (en) | COSMETIC OR DERMATOLOGICAL COMPOSITION CONTAINING AN OIL RICH IN PETROSELINIC ACID | |
| CN109646376A (en) | A kind of whitening moisturizing face masque and preparation method thereof | |
| CN110960458A (en) | Moisturizing essence emulsion and preparation method thereof | |
| CN111481475A (en) | Edible lipstick capable of improving female hormone and preparation method thereof | |
| CN103462835A (en) | Skincare lotion and preparation method thereof | |
| CN105796457A (en) | Scar and pockmark removing lotion rich in natural extracts and preparation method of lotion | |
| CN107970140A (en) | A kind of dispel scar composition and its application containing alligator oil | |
| CN104188859B (en) | A kind of crease-resistant skin care emulsion containing natural component extract and preparation method thereof | |
| CN108403612B (en) | Camel milk skin care emulsion with effects of resisting oxidation and delaying aging and preparation method thereof | |
| CN113384482A (en) | Moisturizing and skin-tendering essence and preparation method thereof | |
| CN105943557B (en) | Anti-rheumatic arthritis cream composition and preparation method thereof | |
| JP2005289999A (en) | Cosmetic composition containing extract of zizyphus jujuba and extract of juglans sinensis | |
| CN104188808B (en) | A kind of nti-freckle is dispelled yellow gel and preparation method thereof | |
| CN108379212B (en) | Camel milk moisturizing cream with anti-aging effect and preparation method thereof | |
| CN110025508A (en) | A kind of essence cream and preparation method thereof preventing striae of pregnancy generation | |
| CN115429738A (en) | Acne-removing repairing revitalizing essence and preparation method thereof | |
| KR102333132B1 (en) | Cosmetic Composition containing Frangipani Oil or Fermented Frangipani Oil | |
| CN111388360A (en) | Bathing essential oil and preparation method thereof | |
| CN111920727A (en) | Body mud film for diminishing inflammation and expelling toxin and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220704 Address after: 737399 first floor of the old office of the court in Badain Jaran Town, Alxa Right Banner, Alxa League, Inner Mongolia Autonomous Region Patentee after: Inner Mongolia tiantuo Biotechnology Co.,Ltd. Address before: 737300 old office building of Alxa Right Banner court, Alxa League, Inner Mongolia Patentee before: INNER MONGOLIA CAMEL Research Institute |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A kind of camel humps hand cream with moisturizing and anti-cracking effect and preparation method thereof Effective date of registration: 20220906 Granted publication date: 20200331 Pledgee: Bank of China Limited BAYANHOT branch Pledgor: Inner Mongolia tiantuo Biotechnology Co.,Ltd. Registration number: Y2022150000096 |