CN106420445B - A kind of skin matrix and the preparation method and application thereof with moisturizing and anti-oxidation efficacy - Google Patents
A kind of skin matrix and the preparation method and application thereof with moisturizing and anti-oxidation efficacy Download PDFInfo
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- CN106420445B CN106420445B CN201610833156.7A CN201610833156A CN106420445B CN 106420445 B CN106420445 B CN 106420445B CN 201610833156 A CN201610833156 A CN 201610833156A CN 106420445 B CN106420445 B CN 106420445B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention belongs to cosmetic technical fields, specifically disclose a kind of skin matrix with moisturizing and anti-oxidation efficacy, are grouped as by the group of the following meter of score by weight: apple berry extract 25 ~ 30；Sensor Chip CM 5 sodium 20 ~ 25；Oligomerization Sodium Hyaluronate 2 ~ 3；Water-soluble fullerene 6 ~ 10；The profound water 15 ~ 20 of platinum；Water 12 ~ 32.The present invention optimizes its dosage by reasonably combined both effectiveness substance, so that four kinds of active effect substances realize complementation, can be degraded, fully absorb by skin, provide nutrition for skin, have long-acting moisturizing and antioxidant effect.Skin matrix prepared by the present invention can make an addition in the cosmetics such as face cream, lotion, toner, can be promoted cosmetics moisturizing and anti-oxidation efficacy, make skin water profit, high resilience, prevent skin aging.
Description
Technical field
The invention belongs to cosmetic technical fields, more particularly, to a kind of skin care with moisturizing and anti-oxidation efficacy
Matrix and the preparation method and application thereof.
Background technique
When skin surface, that is, cuticula moisture content reaches 15~25%, when aqueous sufficient, skin not only can soft smooth do not have
There is microgroove, it also can be full of elasticity in feel；But with advancing age with undesirable life style, cuticula moisture content gradually flows
It loses, when content is lower than 10%, skin just will appear drying, microgroove, tight, coarse and furfur etc..However, air-conditioning, environment are dirty
Dye, Seasonal conversion bring temperature change and pressure and skin aging, metabolism, which such as slow down at the factors, can all cause skin moisture content stream
It loses, replenishing water and preserving moisture is the basis of skin nursing.
Free radical can accelerate the aging of skin, oxygen radical (ROS) due to many factors (alcohol, tobacco etc. it is endogenous because
The outside environmental elements such as element and pollution, ultraviolet radioactive) and constantly accumulate.Our human bodies itself have the protection system for resisting free radical
System: the antioxidant of interior life (there is enzymatic activity or non-enzymatic activity).But in ageing process, the protective effect of these systems
It is not very effectively, in order to inhibit skin premature aging, it is necessary to which outside uses antioxidant.It is anti-oxidant by Management of Cosmetics Enterprises
It is classified as one of most important functional demand of one of main R&D direction and market.
As the improvement of people's living standards, people increasingly pay attention to the nursing and maintenance to autologous skin.Traditional change
Cosmetic effect is single, can not combine good performance of keeping humidity and efficient antioxygenic property.The cosmetics now sold generally are deposited
Active constituent is oxidizable, moistening effect duration is poor, moisture-keeping function can only rest on cuticula, can not fundamentally solve skin
The defect of the dry problem of skin.Therefore, research hair outputs that a kind of moistening effect duration is good, moistening effect can penetrate into corium
Layer, inoxidizability is strong, fundamentally solves the problems, such as that the cosmetics of dry skin and removing free radical, anti-aging are to study at present
Important directions.
Summary of the invention
It is a kind of with moisturizing and anti-oxidation efficacy it is an object of the invention to provide according to deficiency in the prior art
Skin matrix and the preparation method and application thereof.
Another object of the present invention is to provide the preparation method and application of above-mentioned skin matrix.
The purpose of the present invention is achieved through the following technical solutions:
The skin matrix with moisturizing and anti-oxidation efficacy that the present invention provides a kind of, by the group of the following meter of score by weight
It is grouped as:
Preferably, it is grouped as by the group of the following meter of score by weight:
Preferably, the carboxymethyl R-glucan sodium greater than 1%, the carboxymethyl β-are contained in the Sensor Chip CM 5 sodium
1,3 structures account for 80% or more in dextran sodium；Fullerene content is 0.03% in the water-soluble fullerene.
Preferably, the mass percent concentration of platinum is 450~1500ppm in the profound water of the platinum, average of platinum
Grain diameter is 2 nanometers.
Present invention simultaneously provides the preparation methods of above-mentioned skin matrix, include the following steps:
S1. under the conditions of 40 DEG C~50 DEG C, oligomerization Sodium Hyaluronate is added to the water, is stirred, it is saturating to obtain oligomerization after homogeneous
Bright matter acid sodium solution；
S2. apple berry extract, Sensor Chip CM 5 sodium, water-soluble fullerene, platinum Xuan Shui are added to few obtained by S1
In poly- sodium hyaluronate solution, up to the skin matrix after stirring.
Preferably, the speed of stirring described in step S1 is 800~1000rpm；The speed of the homogeneous be 1000~
1500rpm。
Preferably, the speed of stirring described in step S2 is 800~1000rpm.
The present invention also provides application of the above-mentioned skin matrix in cosmetics.
Further, weight percent of the skin matrix in cosmetics is 5~20%.
The cosmetics are grouped as by following group by mass percentage:
Component A: methyl sesquistearate 0.8%~1.2%, PEG-20 methyl sesquistearate 1%
~1.4%, saualane 4%~5%, dimethyl silicone polymer 3%~4%, avocado oil 2%~3%, isononyl isononanoate 3%
~4%, grape seed oil 0.5%~1.5%, propylben 0.08~0.12%；
B component: carbomer 0.1%~0.14%, acrylate copolymer 0.15%~0.25%, glycerol 8%~10%, third
Glycol 5%~10%, maize gluten amino acids 2%~3%, methylparaben 0.12%~0.2%, water 30%~
60%；
Component C: aminomethyl propanol 0.1%~0.14%；
D composition: Chinese gooseberry berry extract 2%~3%, edelweiss extract 3%~4%, Phenoxyethanol
0.2%~0.3%；
Component E: the skin matrix 5%~20%.
Sensor Chip CM 5 sodium selected by the present invention is that 1,3~1,6 structures account for 85%, 1,6 based on 1,3 structure
Structure only has 15%.1,3 structure energy specific recognition Lang Gehanshi cell, Isosorbide-5-Nitrae, 1,6 structure cannot then identify, sell on the market
Most of dextran sodium be with Isosorbide-5-Nitrae, based on 1,6 structure, from this point on this it appears that our Sensor Chip CM 5 sodium it is excellent
Based on gesture structure, 1,3 structure energy specific recognition immunocyte-Lang Gehanshi cell activates the Lang Gehanshi cell of skin.Lang Ge
Rare formula cell secretion of cytokines F EGF etc., thus promote collagen, elastin laminin synthesis with reach extraordinary moisturizing,
Anti-aging and anti-wrinkle effect；The immunocyte Lang Gehanshi cell of activation causes immune cascades to react, and cutaneous immunisation power increases
It is anti-infective simultaneously to accelerate wound healing to have, promote sunburn reparation, anti-radiation effect.The carboxymethyl used in the present invention
Carboxymethyl R-glucan sodium content is higher than 1% in dextran sodium, and molecular weight is in 500~1000KD or so.
Platinum Xuan Shui is the aqua containing platinum, negatively charged nano metal platinum particle make surrounding hydrone from
Solution is hydrogen ion and hydroxide ion, directly and constantly can provide electronics to skin to rebuild and answer new skin, be allowed to become
It is more fresh and alive, younger.It can be used as skin electron donor, skin is made to keep energy balance state while can also strengthen skin to freedom
The defence capability of base, environmental factor and other various injuries, and then skin ageing is resisted, reduce the migration (Victoria C for enlivening oxygen atom
And the antioxidant of dimension E type, just lose oxidation resistance after itself being oxidized, and the profound water of platinum will not).It is adopted in the present invention
For platinum content in 450~1500ppm, average grain diameter is 2 nanometers in the profound water of platinum.
The football shaped molecule that fullerene is made of 60 carbon atoms, diameter about 0.7nm, with superpower anti-with duration
Oxidability.Water-soluble fullerene can eliminate it is various under the conditions of generated active oxygen, especially ultraviolet light irradiation under still can
Stablize and plays superpower resistance to oxidation.There is whitening, crease-resistant, whelk nursing etc. simultaneously, oxidation resistance is ascorbic
125 times.Fullerene content 0.03% in the water-soluble fullerene used in the present invention.Water-soluble fullerene used in the present invention
Can eliminate it is various under the conditions of generated active oxygen, especially ultraviolet light irradiation under still can stablize play it is superpower anti-oxidant
Power.
Apple berry extract is using apple as natural products made of Raw material processing, and main active is Polyphenols object
Matter, apple polyphenol are the common names of contained polyatomic phenol substance in apple.Research shows that apple extract has stronger also proper energy
Power has apparent superiority with the vitamin C of comparable sodium in the inhibition of free radical and elimination effect.With good guarantor
Moist and brilliant inoxidizability.
Compared with prior art, the present invention has the following advantages and beneficial effects:
The present invention, as main composition, passes through the interaction between each ingredient by four kinds of ingredients of experiment sieving
That is synergistic function plays moisturizing and anti-oxidation efficacy to greatest extent.In addition, the present invention not only has moisturizing and anti-oxidant
Effect also has the effect of whitening, crease-resistant.It can be skin since active constituent of the invention can be fully absorbed by skin
Nutrition is provided, there is long-acting moisturizing and antioxidant effect.Skin matrix prepared by the present invention is made an addition into face cream, lotion, makeup
In the cosmetics such as water, good moisturizing and anti-oxidation efficacy can be brought to these products, makes skin water profit, high resilience, prevention
Skin aging.
Specific embodiment
Further illustrate the present invention below in conjunction with specific embodiment, but embodiment the present invention is not done it is any type of
It limits.Unless stated otherwise, the present invention uses reagent, method and apparatus is the art conventional reagents, method and apparatus.
Unless stated otherwise, agents useful for same and material of the present invention are commercially available.
Wherein, apple berry extract, come from South Korea BIOLAND company, trade name APPLE CLEAR JUICE), carboxylic first
Base dextran sodium comes from Japan Vitamin C60 from Chinese Angel Yeast Co., Ltd, water-soluble fullerene
Bioresearch Corporation company, trade name Radical Sponge, platinum Xuan Shui are public from Japan INOVEX
Department, trade name HAKKIN-GENSUI 500.
Embodiment 1
1, a kind of preparation method of the skin matrix with moisturizing and anti-oxidation efficacy, specific steps are as follows:
Stirring (revolving speed 800rpm) is opened to be slowly added to the oligomerization Sodium Hyaluronate of 2 parts by weight under the conditions of 50 DEG C
In the deionized water of 27 parts by weight, constant temperature stirs 50min, low speed homogeneous 4min, and homogeneous speed is 1200rpm, and it is saturating to obtain oligomerization
Bright matter acid sodium solution；
By the apple berry extract of 25 parts by weight, the Sensor Chip CM 5 sodium of 25 parts by weight, 6 parts by weight water-soluble fowler
Alkene and the platinum Xuan Shui of 15 parts by weight are added in oligomerization sodium hyaluronate solution, stir 20min, are cooled to 20 DEG C, and discharging obtains
To the skin matrix with moisturizing and anti-oxidation efficacy.
2, a kind of essence cream (including the cosmetics of skin matrix) comprising skin matrix, by pressing matter below
The group of amount percentages is grouped as:
Component A: methyl sesquistearate (emulsifier) 0.8%, PEG-20 methyl sesquistearate (cream
Agent) 1%, saualane 4%, dimethyl silicone polymer 3%, avocado oil 2%, isononyl isononanoate 3%, grape seed oil 0.5%,
Propylben 0.1%
B component: CB (carbomer) 0.1%, AVC (acrylate copolymer) 0.2%, glycerol 8%, propylene glycol 5%, corn paddy
Histone amino acids 2%, methylparaben 0.2%, deionized water 54.8%
Component C: PC2000 (aminomethyl propanol) 0.1%,
D composition: Chinese gooseberry berry extract 2%, edelweiss extract 3%, Phenoxyethanol 0.2%
Component E: above-mentioned skin matrix 10%.
A kind of preparation method of the essence cream comprising skin matrix:
Portions of de-ionized water is added in aqua pot, maximum stirring is opened, CB (carbomer) is sprinkled into after being stirred until homogeneous,
It is sprinkled into AVC (acrylate copolymer) again, stirs evenly, is warming up to (70 ± 1) DEG C or more, glycerol, propylene glycol, Metagin is added
Ester, maize gluten amino acids are stirred for being heated to (85 ± 1) DEG C, and Material is pumped into emulsion pot after keeping the temperature 15min, is opened
Homogeneous (1000rpm) 2min at a slow speed is opened, then insulated and stirred 15min (note: reserved part deionized water flushing oil phase pot and water phase
Pot residual Material, is then evacuated in emulsion pot)；
Oily phase raw material B component is put into one by one in oily phase pot, heating, stirring to (85 ± 1) DEG C, insulated and stirred are opened
10min melts completely to Material；
The oily phase pot raw material for being up to temperature is pumped into emulsion pot, and oil opens stirring 2min after mutually exhausting, and is then turned on outer
Homogeneous (2500rpm) 3~5min (cauldron Material beats outer homogeneous 5min, and pannikin Material beats outer homogeneous 3min), is then cooled to (70
± 1) DEG C, stop cooling, open homogeneous (1000rpm) 3min after stirring 2min is added in component C, then proceed to cool down；
When temperature is down to (45 ± 1) DEG C, D component is added one by one, it is equal to Material to mix slowly (250rpm) 15min
It is even, it then proceedes to be cooled to (38 ± 1) DEG C addition component E, mixes slowly (250rpm) 15min discharging, obtain comprising skin care base
The essence cream of matter.
Embodiment 2
1, a kind of preparation method of the skin matrix with moisturizing and anti-oxidation efficacy, specific steps are as follows:
Stirring (revolving speed 800rpm) is opened, under the conditions of 50 DEG C, by the oligomerization Sodium Hyaluronate (China of 2.5 parts by weight
Fu Ruida company, trade name nano HA) it is slowly added in the deionized water of 22 parts by weight, constant temperature stirs 50min, low speed homogeneous
4min, homogeneous speed are 1200rpm, obtain oligomerization sodium hyaluronate solution；
By the apple berry extract of 27.5 parts by weight, the Sensor Chip CM 5 sodium of 22.5 parts by weight, 8 parts by weight water solubility
Fullerene and the platinum Xuan Shui of 17.5 parts by weight are added in oligomerization sodium hyaluronate solution, stir 20min, are cooled to 20 DEG C,
Discharging, obtains the skin matrix with moisturizing and anti-oxidation efficacy.
2, a kind of essence cream (including the cosmetics of skin matrix) comprising skin matrix, by pressing matter below
The group of amount percentages is grouped as:
Component A: methyl sesquistearate (emulsifier) the 1%, (emulsification of PEG-20 methyl sesquistearate
Agent) 1.2%, saualane 4.5%, dimethyl silicone polymer 3.5%, avocado oil 2.5%, isononyl isononanoate 3.5%, grape pip
Oily 1%, propylben 0.1%.
B component: CB (carbomer) 0.12%, AVC (acrylate copolymer) 0.2%, glycerol 9%, propylene glycol 7.4%, jade
Oryzenin amino acids 2.5%, methylparaben 0.2%, deionized water 42%.
Component C: PC2000 (aminomethyl propanol) 0.10%,
D composition: Chinese gooseberry berry extract 2.5%, edelweiss extract 3.4%, Phenoxyethanol 0.24%
Component E: above-mentioned skin matrix 15%
A kind of preparation method of the essence cream comprising skin matrix:
Portions of de-ionized water is added in aqua pot, maximum stirring is opened, CB (carbomer) is sprinkled into after being stirred until homogeneous,
It is sprinkled into AVC (acrylate copolymer) again, stirs evenly, is warming up to (70 ± 1) DEG C or more, glycerol, propylene glycol, Metagin is added
Ester, maize gluten amino acids are stirred for being heated to (85 ± 1) DEG C, and Material is pumped into emulsion pot after keeping the temperature 15min, is opened
Homogeneous (1000rpm) 2min at a slow speed is opened, then insulated and stirred 15min (note: reserved part deionized water flushing oil phase pot and water phase
Pot residual Material, is then evacuated in emulsion pot)；
Oily phase raw material B component is put into one by one in oily phase pot, heating, stirring to (85 ± 1) DEG C, insulated and stirred are opened
10min melts completely to Material；
The oily phase pot raw material for being up to temperature is pumped into emulsion pot, and oil opens stirring 2min after mutually exhausting, and is then turned on outer
Homogeneous (2500rpm) 3~5min (cauldron Material beats outer homogeneous 5min, and pannikin Material beats outer homogeneous 3min), is then cooled to (70
± 1) DEG C, stop cooling, open homogeneous (1000rpm) 3min after stirring 2min is added in component C, then proceed to cool down；
When temperature is down to (45 ± 1) DEG C, D component is added one by one, it is equal to Material to mix slowly (250rpm) 15min
It is even, it then proceedes to be cooled to (38 ± 1) DEG C addition component E, mixes slowly (250rpm) 15min discharging, obtain comprising skin care base
The essence cream of matter.
Embodiment 3
1, a kind of preparation method of the skin matrix with moisturizing and anti-oxidation efficacy, specific steps are as follows:
Stirring (revolving speed 800rpm) is opened, under the conditions of 50 DEG C, by oligomerization Sodium Hyaluronate (the Chinese good fortune of 3 parts by weight
Rui Da company, trade name nano HA) it is slowly added in the deionized water of 17 parts by weight, constant temperature stirs 50min, low speed homogeneous
4min, homogeneous speed are 1200rpm, obtain oligomerization sodium hyaluronate solution；
The water solubility of the apple berry extract of 30 parts by weight, the Sensor Chip CM 5 sodium of 20 parts by weight, 10 parts by weight is rich
The platinum Xuan Shui for strangling alkene and 20 parts by weight is added in oligomerization sodium hyaluronate solution, stirs 20min, is cooled to 20 DEG C, discharges,
Obtain the skin matrix with moisturizing and anti-oxidation efficacy.
2, a kind of essence cream (including the cosmetics of skin matrix) comprising skin matrix, by pressing matter below
The group of amount percentages is grouped as:
Component A: methyl sesquistearate (emulsifier) 1.2%, PEG-20 methyl sesquistearate (cream
Agent) 1.3%, saualane 5%, dimethyl silicone polymer 3%, avocado oil 3%, isononyl isononanoate 4%, grape seed oil
1.5%, propylben 0.1%
B component: CB (carbomer) 0.14%, AVC (acrylate copolymer) 0.2%, glycerol 10%, propylene glycol 10%, jade
Oryzenin amino acids 3%, methylparaben 0.12%, deionized water 30%
Component C: PC2000 (aminomethyl propanol) 0.14%,
D composition: Chinese gooseberry berry extract 3%, edelweiss extract 4%, Phenoxyethanol 0.3%
Component E: above-mentioned skin matrix 20%
A kind of preparation method of the essence cream comprising skin matrix:
Portions of de-ionized water is added in aqua pot, maximum stirring is opened, CB (carbomer) is sprinkled into after being stirred until homogeneous,
It is sprinkled into AVC (acrylate copolymer) again, stirs evenly, is warming up to (70 ± 1) DEG C or more, glycerol, propylene glycol, Metagin is added
Ester, maize gluten amino acids are stirred for being heated to (85 ± 1) DEG C, and Material is pumped into emulsion pot after keeping the temperature 15min, is opened
Homogeneous (1000rpm) 2min at a slow speed is opened, then insulated and stirred 15min (note: reserved part deionized water flushing oil phase pot and water phase
Pot residual Material, is then evacuated in emulsion pot)；
Oily phase raw material B component is put into one by one in oily phase pot, heating, stirring to (85 ± 1) DEG C, insulated and stirred are opened
10min melts completely to Material；
The oily phase pot raw material for being up to temperature is pumped into emulsion pot, and oil opens stirring 2min after mutually exhausting, and is then turned on outer
Homogeneous (2500rpm) 3~5min (cauldron Material beats outer homogeneous 5min, and pannikin Material beats outer homogeneous 3min), is then cooled to (70
± 1) DEG C, stop cooling, open homogeneous (1000rpm) 3min after stirring 2min is added in component C, then proceed to cool down；
When temperature is down to (45 ± 1) DEG C, D component is added one by one, it is equal to Material to mix slowly (250rpm) 15min
It is even, it then proceedes to be cooled to (38 ± 1) DEG C addition component E, mixes slowly (250rpm) 15min discharging, obtain comprising skin care base
The essence cream of matter.
Comparative example 1:
A kind of preparation method of the skin matrix with moisturizing and anti-oxidation efficacy, specific steps are as follows:
Stirring (revolving speed 800rpm) is opened to be slowly added to the oligomerization Sodium Hyaluronate of 3 parts by weight under the conditions of 50 DEG C
In the deionized water of 47 parts by weight, constant temperature stirs 50min, low speed homogeneous 4min, and homogeneous speed is 1200rpm, and it is saturating to obtain oligomerization
Bright matter acid sodium solution；
By the platinum Xuan Shui of 20 parts by weight, 30 parts by weight apple berry extract, be added oligomerization sodium hyaluronate solution in,
20min is stirred, is cooled to 20 DEG C, discharging obtains the skin matrix with moisturizing and anti-oxidation efficacy.
A kind of essence cream cosmetics of skin matrix (include) comprising skin matrix, by it is following by mass percentage
Group be grouped as: each component and content include the essence cream of skin matrix with embodiment 3: preparation method is the same as in embodiment 3
The preparation method of essence cream.
Comparative example 2:
A kind of preparation method of the skin matrix with moisturizing and anti-oxidation efficacy, specific steps are as follows:
Stirring (revolving speed 800rpm) is opened to be slowly added to the oligomerization Sodium Hyaluronate of 3 parts by weight under the conditions of 50 DEG C
In the deionized water of 57 parts by weight, constant temperature stirs 50min, low speed homogeneous 4min, and homogeneous speed is 1200rpm, and it is saturating to obtain oligomerization
Bright matter acid sodium solution；
By the platinum Xuan Shui of 20 parts by weight, the Sensor Chip CM 5 sodium of 20 parts by weight, oligomerization sodium hyaluronate solution is added
In, 20min is stirred, is cooled to 20 DEG C, discharging obtains the skin matrix with moisturizing and anti-oxidation efficacy.
A kind of essence cream cosmetics of skin matrix (include) comprising skin matrix, by it is following by mass percentage
Group be grouped as: each component and content include the essence cream of skin matrix with embodiment 3: preparation method is the same as in embodiment 3
The preparation method of essence cream.
Comparative example 3:
A kind of preparation method of the skin matrix with moisturizing and anti-oxidation efficacy, specific steps are as follows:
Stirring (revolving speed 800rpm) is opened to be slowly added to the oligomerization Sodium Hyaluronate of 3 parts by weight under the conditions of 50 DEG C
In the deionized water of 67 parts by weight, constant temperature stirs 50min, low speed homogeneous 4min, and homogeneous speed is 1200rpm, and it is saturating to obtain oligomerization
Bright matter acid sodium solution；
The platinum Xuan Shui of 20 parts by weight, the water-soluble fullerene of 10 parts by weight are added in oligomerization sodium hyaluronate solution,
20min is stirred, is cooled to 20 DEG C, discharging obtains the skin matrix with moisturizing and anti-oxidation efficacy.
A kind of essence cream cosmetics of skin matrix (include) comprising skin matrix, by it is following by mass percentage
Group be grouped as: each component and content include the essence cream of skin matrix with embodiment 3: preparation method is the same as in embodiment 3
The preparation method of essence cream.
Compliance test result:
A kind of essence cream (including the cosmetics of skin matrix) trial effect test comprising skin matrix:
Tested crowd: 30 volunteers's (male and female of the age between 22-35 one full year of life),
Test method: twice daily in the dermal application test sample of inboard arm.After 28 days, volunteers stay in one
Ge Re humidity room (23 DEG C, humidity 50%), executes test cited below.
1. the measurement of water content in horny layer of epidermis
Water content determination in cuticula 5 times calculates average value.Change rate after surveying 28 days.It is applied in test
VISIA-CR skin of face image analyzer.
2, test oxidation resistance uses ORAC method (oxyradical absorbability), and oxyradical absorbs energy
Power is also known as oxidation resistance.ORAC analysis method is to destroy fluorescence probe according to free radical, so that fluorescence intensity is generated variation former
Reason, using vitamin E water-soluble analogues Trolox as quantitative criterion, is analyzed using fluorescence microplate analyzer.Fluorescence is strong
The degree that the variation size reflection free radical of degree destroys.In the presence of antioxidant, it can inhibit glimmering as caused by free radical
Light variation.Inhibition level reflects its oxidation resistance to free radical.The content superelevation of ORAC, inhibits the anti-oxidant of free radical
Ability is stronger.
Its test result is as shown in table 1:
Table 1
From test result as can be seen, the effect of the cream of essence prepared by embodiment 3 is best；It is added in skin matrix
Whole components (apple berry extract, Sensor Chip CM 5 sodium, oligomerization Sodium Hyaluronate, water-soluble fullerene, platinum Xuan Shui and
Deionized water) Examples 1 to 3 effect got well than the effect of comparative example 1~3.Above-mentioned skin matrix is added in cosmetics
Examples 1 to 3 essence cream effect it is also significantly more preferable than the essence cream effect of comparative example 1~3, show the skin matrix
In each ingredient moisturizing and in terms of have and mutually act synergistically and obtain preferable effect.
Claims (9)
1. a kind of skin matrix with moisturizing and anti-oxidation efficacy, which is characterized in that by the component of the following meter of score by weight
Composition:
Wherein for platinum content in 450~1500ppm, average grain diameter is 2 nanometers in the profound water of platinum.
2. skin matrix according to claim 1, which is characterized in that be grouped as by the group of the following meter of score by weight:
3. skin matrix according to claim 1 or 2, which is characterized in that contain in the Sensor Chip CM 5 sodium and be greater than
1% carboxymethyl R-glucan sodium, 1,3 structures account for 80% or more in the carboxymethyl R-glucan sodium；It is described water-soluble rich
Strangling fullerene content in alkene is 0.03%.
4. a kind of preparation method of skin matrix described in claim 1, which comprises the steps of:
S1. under the conditions of 40 DEG C~50 DEG C, oligomerization Sodium Hyaluronate is added to the water, is stirred, obtains oligomerization hyalomitome after homogeneous
Acid sodium solution；
S2. it is saturating apple berry extract, Sensor Chip CM 5 sodium, water-soluble fullerene, platinum Xuan Shui to be added to oligomerization obtained by S1
In bright matter acid sodium solution, up to the skin matrix after stirring.
5. the preparation method according to claim 4, which is characterized in that the speed of stirring described in step S1 be 800~
1000rpm；The speed of the homogeneous is 1000~1500rpm.
6. the preparation method according to claim 4, which is characterized in that the speed of stirring described in step S2 be 800~
1000rpm。
7. application of the skin matrix of any of claims 1 or 2 in cosmetics.
8. application according to claim 7, which is characterized in that weight percent of the skin matrix in cosmetics be
5~20%.
9. cosmetics according to claim 8, which is characterized in that be grouped as by following group by mass percentage:
Component A: methyl sesquistearate 0.8%~1.2%, PEG-20 methyl sesquistearate 1%~
1.4%, saualane 4%~5%, dimethyl silicone polymer 3%~4%, avocado oil 2%~3%, isononyl isononanoate 3%~
4%, grape seed oil 0.5%~1.5%, propylben 0.08~0.12%；
B component: carbomer 0.1%~0.14%, acrylate copolymer 0.15%~0.25%, glycerol 8%~10%, propylene glycol
5%~10%, maize gluten amino acids 2%~3%, methylparaben 0.12%~0.2%, water 30%~60%；
Component C: aminomethyl propanol 0.1%~0.14%；
D composition: Chinese gooseberry berry extract 2%~3%, edelweiss extract 3%~4%, Phenoxyethanol 0.2%~
0.3%；
Component E: the skin matrix 5%~20%.
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| CN106943306B (en) * | 2017-03-26 | 2018-07-31 | 花安堂生物科技集团有限公司 | A kind of nanometer platinum colloid for cosmetics |
| CN107440914A (en) * | 2017-03-26 | 2017-12-08 | 广州市花安堂生物科技有限公司 | Nanometer platinum colloid for cosmetics |
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| CN107088183B (en) * | 2017-06-08 | 2019-05-21 | 花安堂生物科技集团有限公司 | A kind of cosmetic material and preparation method thereof |
| CN108324646A (en) * | 2018-04-16 | 2018-07-27 | 广州雷诺生物科技有限公司 | A kind of moisturizer containing fullerene |
| CN108652994B (en) * | 2018-08-03 | 2019-11-29 | 广东丸美生物技术股份有限公司 | It is a kind of with moisturizing, improve wrinkle and the skin matrix of anti-oxidation efficacy and its preparation method and application |
| CN112438916A (en) * | 2019-08-30 | 2021-03-05 | 广州鹰远生物科技有限公司 | Skin-care matrix with antioxidant effect and preparation method and application thereof |
| CN111166683A (en) * | 2019-12-28 | 2020-05-19 | 嘉汶化妆品(东莞)有限公司 | Fullerene anti-aging antioxidant beauty and skin care cosmetic and preparation method thereof |
| CN111437223A (en) * | 2020-04-12 | 2020-07-24 | 广州市索柔生物科技有限公司 | Skin care composition with blue light resisting effect and preparation thereof |
| CN115887271B (en) * | 2022-11-28 | 2023-07-25 | 湖北万德瑞生命科学技术有限公司 | NMN-containing anti-aging moisturizing water and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1832719A (en) * | 2003-05-30 | 2006-09-13 | 奈尔·伯兰古洛夫 | Cosmetic compositions containing fullerene clusters |
| CN104490747A (en) * | 2015-01-05 | 2015-04-08 | 深圳市金因生物技术有限公司 | Radiation-resistant and photo-protective composition with total-effect defense function and preparation method thereof |
| CN104523490A (en) * | 2014-12-11 | 2015-04-22 | 广州栋方日化有限公司 | Exfoliate composition with whitening and moisturizing effects and preparation method of exfoliate composition |
| CN105078874A (en) * | 2015-09-01 | 2015-11-25 | 嘉文丽（福建）化妆品有限公司 | Novel toning lotion matched with hydrogen-rich apparatus for use and preparation method for hydrogen-rich toning lotion |
| CN105147591A (en) * | 2015-10-19 | 2015-12-16 | 广州科玛生物科技有限公司 | Anti-wrinkle face cream and preparation method thereof |
| CN105342904A (en) * | 2015-11-02 | 2016-02-24 | 嘉文丽（福建）化妆品有限公司 | Essence with skin anti-wrinkle effect |
-
2016
- 2016-09-19 CN CN201610833156.7A patent/CN106420445B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1832719A (en) * | 2003-05-30 | 2006-09-13 | 奈尔·伯兰古洛夫 | Cosmetic compositions containing fullerene clusters |
| CN104523490A (en) * | 2014-12-11 | 2015-04-22 | 广州栋方日化有限公司 | Exfoliate composition with whitening and moisturizing effects and preparation method of exfoliate composition |
| CN104490747A (en) * | 2015-01-05 | 2015-04-08 | 深圳市金因生物技术有限公司 | Radiation-resistant and photo-protective composition with total-effect defense function and preparation method thereof |
| CN105078874A (en) * | 2015-09-01 | 2015-11-25 | 嘉文丽（福建）化妆品有限公司 | Novel toning lotion matched with hydrogen-rich apparatus for use and preparation method for hydrogen-rich toning lotion |
| CN105147591A (en) * | 2015-10-19 | 2015-12-16 | 广州科玛生物科技有限公司 | Anti-wrinkle face cream and preparation method thereof |
| CN105342904A (en) * | 2015-11-02 | 2016-02-24 | 嘉文丽（福建）化妆品有限公司 | Essence with skin anti-wrinkle effect |
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