CN108652994B - It is a kind of with moisturizing, improve wrinkle and the skin matrix of anti-oxidation efficacy and its preparation method and application - Google Patents
It is a kind of with moisturizing, improve wrinkle and the skin matrix of anti-oxidation efficacy and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses a kind of with moisturizing, improves wrinkle and the skin matrix of anti-oxidation efficacy and its preparation method and application.The skin matrix includes the component of following mass fraction: water-soluble fullerene 2-12 parts, 1-6 parts of Ectoin, 1-20 parts of Mi Luomu extract, 0.1-20 parts of soluble protein polysaccharide, 0.1-20 parts of elastin hydrolysis, 0.01-1 parts of bitter orange flower oil, 0.1 ~ 10 part of Cremophor RH40,10-35 parts of water.Skin matrix of the invention passes through the interaction between each ingredient, active constituent can be fully absorbed by skin, 30% or so is improved using the water content of the horny layer of epidermis after 4 weeks, applied to 35% or more raising in cosmetics, resisting oxidation free radical ability improves 30%, applied to improving 40% or more in cosmetics, wrinkle decrease rate can reach 20%, and being applied to wrinkle decrease rate in cosmetics is 32%.
Description
Technical field
The present invention relates to skin nursing products technical fields, have moisturizing more particularly, to one kind, improve wrinkle and resist
Skin matrix of oxidation efficiency and its preparation method and application.
Background technique
The research of modern age Celluar and Molecular Biology thinks that skin aging is both the prearranged journey of human gene
Sequence, but there are problems that accelerating ageing process by exogenous damage.Exogenous damage includes many aspects, such as sun spoke
It penetrates, air pollution, slowing down exogenous damage to delay senescence is the hot spot of current cosmetics and related science research and development.
Crease-resistant moisturizing anti-aging cosmetics mainly enter from the most important factor photo-aging of skin aging and free radical at present
Hand adds such as superoxide dismutase (SOD), tocopherol acetate, ascorbic acid, retinol, and free radical is hindered to be formed
Oxide, act on it is relatively simple, while the problems such as there is also stabilitys poor, easy to change and allergy.It adds and protects in cosmetic formulations
Humectant ingredient, addition have moisturizing, the grease of water lock function, emulsifier etc., smear the guarantor that can help to improve skin on the skin
Outlet capacity improves the hydrauture of skin, can play in short term moisture-keeping function.But moistening effect is limited, and dependence is high,
Once stopping using, skin is just unable to water lock, cannot fundamentally effectively improve skin moisturization.With people's life water
Flat raising, people increasingly pay attention to the nursing and maintenance to autologous skin.Traditional cosmetic industry is single, can not be simultaneous simultaneously
Moisturizing and efficient anti-oxidation efficacy are cared for, the present generally existing active constituent of cosmetics on sale is easy to oxidize, moistening effect
Duration is poor, and moistening effect is only capable of the defect for resting on cuticula, can not fundamentally solving the problems, such as dry skin.
Therefore, develop that a moistening effect duration is good, and inoxidizability is strong, fundamentally solve the problems, such as dry skin and
Free radical is removed, the cosmetics of anti-aging are the directions studied at present.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the defects and deficiency of existing moisture-keeping crease-shedding anti-aging skin care product, provide
It is a kind of with moisturizing, improve the skin matrix of wrinkle and anti-oxidation efficacy, by specific fullerene, Mi Luomu extract, according to
Ke Duoyin's etc. is used in compounding, and is acted synergistically by specific component, has reached good moistening effect and inoxidizability, skin care
Matrix can penetrate into skin corium, fundamentally solve the problems, such as dry skin, remove free radical to achieve the effect that anti-aging.
Another mesh of the invention is to provide a kind of preparation method of above-mentioned skin matrix.
Another object of the present invention is to provide a kind of application of above-mentioned skin matrix in cosmetics.
Another object of the present invention is to provide a kind of cosmetics.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of skin matrix with moisturizing, improvement wrinkle and anti-oxidation efficacy, the component including following mass fraction: packet
Include the component of following mass fraction: 2~12 parts of water-soluble fullerene, 1~6 part of Ectoin, Mi Luomu extract 1~20
Part, 0.1~20 part of soluble protein polysaccharide, 0.1~20 part of elastin hydrolysis, 0.01~1 part of bitter orange flower oil, PEG-40 hydrogenation
0.1~10 part of castor oil, 10~35 parts of water.
The football shaped molecule that water-soluble fullerene of the present invention is made of 60 carbon atoms, diameter about 0.7nm, tool
Have it is superpower with duration oxidation resistance, water-soluble fullerene can eliminate it is various under the conditions of generated active oxygen, especially
It can still stablize under ultraviolet light irradiation and play superpower resistance to oxidation, while there is whitening, crease-resistant, whelk nursing etc., resist
Oxidability is ascorbic 125 times.
Ectoin chemical name: 2- methyl-1,4,5,6,-tetrahydropyrimidine -4- carboxylic acid derives from high Halophiles
(Halomonas Elongata), therefore also claim " Facultative Halophiles extract liquor " Ectoin.In with high salt, high temperature, high ultraviolet radiation
Extreme condition under, it is dead that Ectoin is to ensure that high halophagia bacterium is unlikely to dehydration under hypersaline environment, and infiltration is maintained to flatten
The important substance of weighing apparatus, unique molecular structure, with very strong hydrone complexing power, a molecule Ectoin can be complexed
Four, five hydrones can make intracellular free water structuring, be very outstanding moisturizer.Ectoin can be promoted effectively
The immune protection ability of Skin Cell increases cell repair ability, allows the skin to effectively antagonize entering for microorganism and anaphylactogen, energy
DNA Damage caused by ultraviolet light is repaired in injury to uvioresistant to skin.
Close Luo Mu extract can help the super effect moisturizing of skin, reduce the infringement of ultraviolet light, rapidly adapt to environment and weather
Variation, using contain close Luo Mu ingredient close flesh series skin nursing products, can repair damaged cell, adjust skin water and oil balance,
Good skin barrier is formed, there is the powerful anti-oxidation efficacy for resisting free radical, protects membrane structure from Dehydration Injury, enhancing
Cell viability boosts metabolism, and reduces oxidation, protects skin, at least can reach 48 hours to 72 hours long-acting benefits after use
Water can improve facial thin by cortical layer and bring red capillary, efficient water lock moisturizing, long-time service can more improve skin shape
State enables skin compact soft, elastic glossy.
Elastin hydrolysis of the present invention is the important element for forming skin corium, accounts for about 5% in vivo, but administers
95% skin elasticity, elastin hydrolysis can improve coarse skin, have facilitation to the production of collagen, to wrinkle
Line, skin elasticity have improvement situation, have moistening effect.
Soluble protein polysaccharide of the present invention has class EGF effect, can improve coarse skin, raw to hyaluronic acid
Production has facilitation, has facilitation to the production of collagen I, has improvement situation to wrinkle, skin elasticity, have whitening,
Moistening effect.
Bitter orange flower oil of the present invention can enhance cell viability, help cytothesis, increase skin elasticity, enhance skin
Oxidation resistance is suitble to stemness, sensitivity and adult form skin to use, also helpful for other skin problem flores aurantii essential oils,
Especially spiral helicine varication, scar and pregnant occasion line, when according to X-ray, flores aurantii essential oil can be used to protect skin.
The present invention is played moisturizing to greatest extent, is improved by interaction, that is, synergistic function between each ingredient
Wrinkle and anti-oxidation efficacy also have whitening effect.Since active constituent of the invention can be fully absorbed by skin, Ke Yiwei
Skin provides nutrition, has long-acting moisturizing, improves wrinkle and antioxidant effect.Skin matrix prepared by the present invention is made an addition into face
In the cosmetics such as frost, lotion, toner, good moisturizing can be brought to these products, improves wrinkle and anti-oxidation efficacy, make flesh
Skin water profit, high resilience, prevent skin aging.
Preferably, the component including following mass fraction: 7~10 parts of water-soluble fullerene, 3.5~4 parts of Ectoin,
20 parts of close Luo Mu extract, 20 parts of soluble protein polysaccharide, 20 parts of elastin hydrolysis, 0.031 part of bitter orange flower oil, PEG-40 hydrogen
Change 0.3 part of castor oil, 25~29 parts of water.
Preferably, the component including following mass fraction: 10 parts of water-soluble fullerene, 4 parts of Ectoin, Mi Luomu are mentioned
Take 20 parts of object, 20 parts of soluble protein polysaccharide, 20 parts of hydrolyzed elastin egg, 0.03 part of bitter orange flower oil, Cremophor RH40 0.3
Part, 25.67 parts of water.
Preferably, the mass content of fullerene is 0.01~50% in the water-soluble fullerene.It is used in the present invention
Water-soluble fullerene can eliminate it is various under the conditions of generated active oxygen, especially ultraviolet light irradiation under can still stablize hair
Wave superpower resistance to oxidation.
Preferably, the mass content of fullerene is 0.03% in the water-soluble fullerene.
Preferably, the close Luo Mu extract is close Luo Muye and/or stem extraction.
Preferably, purity >=50% of the close Luo Mu extract.
The moisturizing antioxidation mechanism of close Luo Mu extract is enhancing Skin Cell vigor and metabolism；Keep aged cells extensive
Multiple young cell state；Cutaneous activation regeneration, enhances Skin Cell inoxidizability (SOD1).
Preferably, the extracting method of the close Luo Mu extract are as follows: each component raw material is all outsourcing in matrix, buys company
It is described in a specific embodiment, need not just write extracting method.
Preferably, purity >=96% of the Ectoin.
Preferably, the purity of the soluble protein polysaccharide is 1%, and the purity of elastin hydrolysis is 1~4.9%
A kind of preparation method of above-mentioned skin care item matrix, includes the following steps:
S1. at 45-55 DEG C, Ectoin is added to the water and is uniformly dissolved, be added that water-soluble fowler is dilute, close Luo Mu is extracted
Object, elastin hydrolysis, soluble protein polysaccharide, dissolution obtain mixture；
S2. Cremophor RH40, bitter orange flower oil are dissolved at 50~60 DEG C, is added in the mixture in S1, mixed
Conjunction obtains the skin matrix.
First that water-soluble fowler is dilute, Mi Luomu extract, elastin hydrolysis, soluble protein polysaccharide mix in preparation method
It closes uniformly, Cremophor RH40 and bitter orange flower oil are uniformly mixed, then the two is mixed together preparation skin matrix, bigarabe flower
Oil is mixed with the dissolution for being conducive to increase bitter orange flower oil with the mixed solution of other components again after mixing with Cremophor RH40
Property.
Preferably, it is uniformly dissolved and is uniformly mixed described in S1 and S2 to stir evenly, mixing speed is 800~1000rpm.
A kind of application of above-mentioned skin care item matrix in cosmetics is also within protection scope of the present invention.The present invention is made
Standby skin matrix makes an addition in the cosmetics such as face cream, lotion, toner, and good moisturizing can be brought to these products, improves
Wrinkle and anti-oxidation efficacy improve coarse skin, prevent skin aging.
Preferably, weight percent of the skin matrix in cosmetics is 5~25% in the application.
A kind of cosmetics include above-mentioned skin matrix in the cosmetics.
Preferably, the cosmetics include the component of following mass parts meter:
A phase: 0.8~1.2 part of methyl sesquistearate, the methyl of PEG~20 sesquistearate 1~1.4
Part, 4~5 parts of carbonic acid dioctyl ester, 3~4 parts of dimethyl silicone polymer, 3~5 parts of isononyl isononanoate, Queensland nut seed oil 0.5~
2.5 parts, 0.08~0.15 part of propylben；
B phase: 0.1~0.14 part of carbomer, 0.2~0.4 part of xanthan gum, 8~10 parts of % of glycerol, 5~10 parts of propylene glycol, general
2~3 parts of alcohol, 0.12~0.25 part of methylparaben, 25~60 parts of water；
C phase: 0.1~0.14 part of aminomethyl propanol；
D phase: snail secretes 2~3 parts of filtrate, 3~4 parts of edelweiss extract, 0.2~0.3 part of Phenoxyethanol；
E phase: described 5~25 parts of skin matrix of any one of claim 1~7.
Compared with prior art, the beneficial effects of the present invention are:
The present invention provides a kind of with moisturizing, improves the skin matrix of wrinkle and anti-oxidation efficacy, by it is each at point it
Between interaction, active constituent can fully absorb by skin, nutrition can be provided for skin, plays moisturizing to greatest extent
And anti-oxidation efficacy, skin matrix of the invention not only has the effect of moisturizing, improvement wrinkle, there are also whitening, anti-oxidant and suppression
The effect of scytitis processed improves 30% or so using the water content of the horny layer of epidermis after 4 weeks, applied to mentioning in cosmetics
High by 35% or more, resisting oxidation free radical ability improves 30%, is applied to improve 40% or more in cosmetics, wrinkle decrease rate can
Reach 20%, being applied to wrinkle decrease rate in cosmetics is 32%.
Specific embodiment
The present invention is further illustrated With reference to embodiment, but embodiment the present invention is not done it is any
The restriction of form.Unless otherwise indicated, source chemicals used in the embodiment of the present invention are the source chemicals routinely bought.
Water-soluble fullerene comes from INOVEX company, Japan, trade name Radical Sponge (water-soluble fullerene)；
Ectoin comes from Bitop company, Germany, trade name ECTOIN；Soluble protein polysaccharide, from a Japanese ball company, quotient
The name of an article is PROTEOGLYCAN；Elastin hydrolysis comes from I.R.A company, Italy, trade name Elastin Marina；It is close
Luo Mu extract comes from Bitop company, Germany, trade name Glycoin Natural；Bitter orange flower oil is from France, trade name
W-AR15003585 neroli oil；Cremophor RH40 comes from BASF, trade name EumulginC040.
Embodiment 1~11
A kind of skin matrix with moisturizing, improvement wrinkle and anti-oxidation efficacy, the group including mass fraction as shown in table 1
Point.
Preparation method specific steps are as follows:
S1. at 50 DEG C, Ectoin is added to the water and is uniformly dissolved, be added dilute water-soluble fowler, Mi Luomu extract,
Close Luo Mu extract, soluble protein polysaccharide, are uniformly dissolved, obtain mixture；
S2. Cremophor RH40, bitter orange flower oil are uniformly dissolved at 50 DEG C, are added in the mixture in S1, mixed
Conjunction uniformly obtains the skin matrix, is cooled to 25 DEG C, discharges,
It is uniformly dissolved and is uniformly mixed described in S1 and S2 to stir evenly, mixing speed 1000rpm.
Table 1
Embodiment 12
A kind of essence cream, is grouped as by following group by mass percentage:
A phase: methyl sesquistearate 0.8%, PEG-20 methyl sesquistearate 1%, carbonic acid two are pungent
Ester 4%, dimethyl silicone polymer 4%, isononyl isononanoate 3%, Queensland nut seed oil 1.5%, propylben 0.12%；
B phase: carbomer 0.12%, xanthan gum 0.3%, glycerol 8%, propylene glycol 6%, panthenol 2%, methylparaben
0.15%, water 49.7%；
C phase: aminomethyl propanol 0.12%；
D phase: snail secretes filtrate 2%, edelweiss extract 4%, Phenoxyethanol 0.2%；
E phase: skin matrix 15% described in embodiment 1；
Essence cream the preparation method comprises the following steps:
Water phase pot is added in part water, stirs speed to maximum, by carbomer, xanthan gum, glycerol, propylene glycol, panthenol, nipalgin
Water phase pot is once added in methyl esters, is warming up to 85 DEG C, and after keeping the temperature 20min, Material is pumped into emulsion pot；
A phase raw material is successively added to oily phase pot one by one, opens oily phase pot stirring, stirs speed to maximum, agitating and heating heating
To 80 DEG C, 15min is kept the temperature
Oily phase pot raw material is slowly pumped into emulsion pot, then leaves Yu Shui, is vacuumized, outer circulation 3-5min, homogeneous speed are opened
2500-3000rpm is spent, emulsion pot starts to cool down, and C phase raw material is added when being cooled to 70 DEG C, vacuumizes, opens outer circulation 2-
3min, homogeneous speed 2000-3000rpm, continues to cool down；
When being cooled to 40-50 DEG C, emulsion pot is added in D phase raw material, 10min is stirred, stirs evenly, continue to be cooled to 36 DEG C
When E phase is added, stir 10min, stir evenly discharging, it is newborn to obtain the essence comprising skin matrix.
Embodiment 13
A kind of essence cream, is grouped as by following group by mass percentage:
A phase: methyl sesquistearate 1%, PEG-20 methyl sesquistearate 1.2%, carbonic acid two are pungent
Ester 4.5%, dimethyl silicone polymer 4.5%, isononyl isononanoate 3.5%, Queensland nut seed oil 2%, propylben
0.12%；
B phase: carbomer 0.13%, xanthan gum 0.3%, glycerol 9%, propylene glycol 7%, panthenol 2.5%, methylparaben
0.15%, water 42.44%；
C phase: aminomethyl propanol 0.13%；
D phase: snail secretes filtrate 2.2%, edelweiss extract 4.1%, Phenoxyethanol 0.23%；
E phase: skin matrix 20% described in embodiment 2；
Essence cream the preparation method comprises the following steps:
Water phase pot is added in part water, stirs speed to maximum, by carbomer, xanthan gum, glycerol, propylene glycol, panthenol, nipalgin
Water phase pot is once added in methyl esters, is warming up to 85 DEG C, and after keeping the temperature 20min, Material is pumped into emulsion pot；
A phase raw material is successively added to oily phase pot one by one, opens oily phase pot stirring, stirs speed to maximum, agitating and heating heating
To 80 DEG C, 15min is kept the temperature
Oily phase pot raw material is slowly pumped into emulsion pot, then leaves Yu Shui, is vacuumized, outer circulation 3-5min, homogeneous speed are opened
2500~3000rpm is spent, emulsion pot starts to cool down, and C phase raw material is added when being cooled to 70 DEG C, vacuumizes, unlatching outer circulation 2~
3min, homogeneous 2000~3000rpm of speed, continues to cool down；
When being cooled to 40~50 DEG C, emulsion pot is added in D component raw material, 10min is stirred, stirs evenly, continue to be cooled to
E phase is added at 36 DEG C, stirs 10min, stirs evenly discharging, obtains the essence cream comprising skin matrix.
Embodiment 14
A kind of essence cream, is grouped as by following group by mass percentage:
A phase: methyl sesquistearate 1.1%, PEG-20 methyl sesquistearate 1.3%, carbonic acid two
Monooctyl ester 4.8%, dimethyl silicone polymer 4.8%, isononyl isononanoate 3.6%, Queensland nut seed oil 2.5%, propylben
0.12%；
B phase: carbomer 0.14%, xanthan gum 0.35%, glycerol 9.5%, propylene glycol 7.5%, panthenol 3%, Metagin
Ester 0.15%, water 28.75%；
C phase: aminomethyl propanol 0.14%；
D phase: snail secretes filtrate 2.5%, edelweiss extract 4.5%, Phenoxyethanol 0.25%；
E phase: skin matrix 25% described in embodiment 3；
Essence cream the preparation method comprises the following steps:
Water phase pot is added in part water, stirs speed to maximum, by carbomer, xanthan gum, glycerol, propylene glycol, panthenol, nipalgin
Water phase pot is once added in methyl esters, is warming up to 85 DEG C, and after keeping the temperature 20min, Material is pumped into emulsion pot；
A phase raw material is successively added to oily phase pot one by one, opens oily phase pot stirring, stirs speed to maximum, agitating and heating heating
To 80 DEG C, 15min is kept the temperature；
Oily phase pot raw material is slowly pumped into emulsion pot, then leaves Yu Shui, is vacuumized, outer circulation 3-5min, homogeneous speed are opened
2500-3000rpm is spent, emulsion pot starts to cool down, and C phase raw material is added when being cooled to 70 DEG C, vacuumizes, opens outer circulation 2-
3min, homogeneous speed 2000-3000rpm, continues to cool down；
When being cooled to 40-50 DEG C, emulsion pot is added in D phase raw material, 10min is stirred, stirs evenly, continue to be cooled to 36 DEG C
When E phase is added, stir 10min, stir evenly discharging, it is newborn to obtain the essence comprising skin matrix.
Comparative example 1
A kind of preparation method with moisturizing, the skin matrix for improving wrinkle and anti-oxidation efficacy, the specific steps are as follows:
Stirring is opened, stirring speed is that the Ectoin of 4 parts by weight is added to 25.67 at 50 DEG C by 800-1000rpm
In the water of parts by weight, stirring and dissolving, then by the soluble protein polysaccharide of 25 parts by weight, the hydrolyzed elastin egg of 25 parts by weight
It is white, it sequentially adds in mixed solution, by the bitter orange flower oil of the Cremophor RH40 of 0.3 parts by weight and 0.03 parts by weight
Mix, be heated with stirring to 50~60 DEG C, it is to be mixed be uniformly dissolved after be added in mixed solution, stir 10min, stir speed not
Become, stir evenly, cold cut is to 25 DEG C, discharging, obtains a kind of above-mentioned skin care base with moisturizing, improvement wrinkle and anti-oxidation efficacy
Matter.
It is a kind of containing above-mentioned skin matrix essence cream, be grouped as by following group by mass percentage: each component and
Preparation method of the content with the essence cream in embodiment 14.
Comparative example 2
A kind of preparation method with moisturizing, the skin matrix for improving wrinkle and anti-oxidation efficacy, the specific steps are as follows:
Stirring is opened, stirring speed is that the Ectoin of 15 parts by weight is added to by 800~1000rpm at 50 DEG C
In the water of 25.67 parts by weight, stirring and dissolving, then by the soluble protein polysaccharide of 20 parts by weight, the hydrolysis of 20 parts by weight
Elastin laminin, the close Luo Mu extract of 20 parts by weight, sequentially adds in mixed solution, by the PEG-40 hydrogen of 0.3 parts by weight
Change castor oil and the bitter orange flower oil of 0.03 parts by weight to mix, be heated with stirring to 50~60 DEG C, it is to be mixed be uniformly dissolved after
Be added in mixed solution, stir 10min, it is constant to stir speed, stirs evenly, and cold cut is to 25 DEG C, discharging, obtain it is above-mentioned it is a kind of have protect
Skin matrix that is wet, improving wrinkle and anti-oxidation efficacy.
It is a kind of containing above-mentioned skin matrix essence cream, be grouped as by following group by mass percentage: each component and
Preparation method of the content with the essence cream in embodiment 14.
Comparative example 3
A kind of preparation method with moisturizing, the skin matrix for improving wrinkle and anti-oxidation efficacy, the specific steps are as follows:
Stirring is opened, stirring speed is that the Ectoin of 4 parts by weight is added to 35.7 weights at 50 DEG C by 800-1000rpm
In the water for measuring number, stirring and dissolving, then by the soluble protein polysaccharide of 20 parts by weight, the hydrolyzed elastin egg of 20 parts by weight
White, the close Luo Mu extract of 20 parts by weight, the water-soluble fullerene of 10 parts by weight sequentially adds in mixed solution, by 0.3
The Cremophor RH40 of parts by weight and the bitter orange flower oil of 2 parts by weight mix, and are heated with stirring to 50~60 DEG C, to
Stirring and dissolving uniformly afterwards be added mixed solution in, stir 10min, stir speed it is constant, stir evenly, cold cut to 25 DEG C, discharging, obtain
A kind of above-mentioned skin matrix with moisturizing, improvement wrinkle and anti-oxidation efficacy.
It is a kind of containing above-mentioned skin matrix essence cream, be grouped as by following group by mass percentage: each component and
Preparation method of the content with the essence cream in embodiment 14.
Comparative example 4~11
As a result it detects
A kind of essence cream trial effect experiment comprising above-mentioned skin matrix:
Tested crowd: 20 volunteers's (sex of the age between 25-35 one full year of life)
Test method: test sample is applied at face wrinkles position twice daily, after 28 days, volunteers stay in one
Hot humidity room's (25 DEG C, humidity 50%), executes following test.
The measurement of water content in horny layer of epidermis
Water content determination in cuticula 5 times, is averaged.Change rate after surveying 28 days, is applied in testing
VISIA-CR skin of face image analyzer.
Test oxidation resistance uses ORAC method (oxyradical absorbability), oxyradical absorbability
Also known as oxidation resistance.ORAC method is to destroy fluorescence probe according to free radical, so that fluorescence intensity is generated variation principle, with dimension
Raw element E water-soluble analogues Trolox is quantitative criterion, is analyzed using fluorescence microplate analyzer.The variation of fluorescence intensity
Size reflects the degree that free radical destroys, and in the presence of antioxidant, it can inhibit change in fluorescence caused by free radical, inhibits
Degree reflects its oxidation resistance to free radical, and the content of ORAC is higher, inhibits the oxidation resistance of free radical stronger.
Test wrinkle improves situation and uses VISIA-CR skin of face image analyzer, observes the wrinkle depth of skin
Analysis, wrinkle decrease rate, the change rate after surveying 28 days.
Test result is as shown in table 2:
Table 2
From test result as can be seen that essence cream effect prepared by embodiment 3 is best；It is added in skin matrix complete
The embodiment 1-3 effect of portion's ingredient is got well than the effect of comparative example 1-3.The effect of embodiment 1-3 essence cream is also obviously than comparison
The essence cream effect of example 1-3 is more preferable, shows that each ingredient has at moisturizing, improvement wrinkle and anti-oxidant aspect in the skin matrix
It cooperates and obtains preferable effect.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in the claims in the present invention within the spirit and principle of invention
Protection scope within.
Claims (10)
1. a kind of skin matrix with moisturizing, improvement wrinkle and anti-oxidation efficacy, which is characterized in that including following mass fraction
Component: 2~12 parts of water-soluble fullerene, 1~6 part of Ectoin, 1~20 part of Mi Luomu extract, soluble protein are more
Sugared 0.1~20 part, 0.1~20 part of elastin hydrolysis, 0.01~1 part of bitter orange flower oil, Cremophor RH40 0.1~10
Part, 10~35 parts of water.
2. skin matrix as described in claim 1, which is characterized in that the component including following mass fraction: water-soluble fowler
10 parts of alkene, 4 parts of Ectoin, 20 parts of Mi Luomu extract, 20 parts of soluble protein polysaccharide, 20 parts of hydrolyzed elastin egg, bigarabe flower
Oily 0.03 part, 0.3 part of Cremophor RH40,25.67 parts of water.
3. skin matrix as described in claim 1, which is characterized in that the close Luo Mu extract is that close Luo Muye and/or stem mention
Take object.
4. skin matrix as claimed in claim 3, which is characterized in that purity >=50% of the close Luo Mu extract.
5. skin matrix as described in claim 1, which is characterized in that purity >=96% of the Ectoin.
6. skin matrix as described in claim 1, which is characterized in that the purity of the soluble protein polysaccharide is 1%, the water
The purity for solving elastin laminin is 1~4.9%.
7. the preparation method of skin matrix as described in any one of claim 1~6, which comprises the steps of:
S1. at 45-55 DEG C, Ectoin is added to the water and is uniformly dissolved, be added dilute water-soluble fowler, Mi Luomu extract,
Elastin hydrolysis, soluble protein polysaccharide, dissolution obtain mixture；
S2. Cremophor RH40, bitter orange flower oil are dissolved at 50~60 DEG C, is added in the mixture in S1, mixes
To the skin matrix.
8. a kind of application of any one of claim 1~6 skin matrix in cosmetics.
9. application as claimed in claim 8, which is characterized in that weight percent of the skin matrix in cosmetics in the application
It is 5~25%.
10. a kind of cosmetics, which is characterized in that include any one of claim 1~6 skin matrix in the cosmetics.
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| CN109820739A (en) * | 2018-11-27 | 2019-05-31 | 广州瑞誉化工科技有限公司 | A kind of skin composition and its preparation method and application of Plantain skin lightening |
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| CN109939025A (en) * | 2019-03-22 | 2019-06-28 | 广东润洁日化有限公司 | A kind of skin cream of opponent's foot chapped skin repair function |
| CN110269818A (en) * | 2019-05-14 | 2019-09-24 | 广州辰美化妆品有限公司 | Composition for skin care item |
| CN110123652B (en) * | 2019-06-24 | 2022-01-07 | 广州澳希亚实业有限公司 | Essence for improving skin state and preparation method thereof |
| CN110123705B (en) * | 2019-06-24 | 2022-01-07 | 广州澳希亚实业有限公司 | Moisturizing and anti-wrinkle composition and skin care product |
| CN110575410A (en) * | 2019-09-16 | 2019-12-17 | 安婕妤化妆品科技股份有限公司 | Cosmetic containing blue light-shielding component |
| CN110946814A (en) * | 2020-01-18 | 2020-04-03 | 杭州倍荣生物科技有限公司 | Skin mesoderm repair liquid and preparation method thereof |
| CN111358734A (en) * | 2020-04-10 | 2020-07-03 | 上海新高姿化妆品有限公司 | A warehouse-separated anti-aging cosmetic composition |
| CN111505002A (en) * | 2020-04-29 | 2020-08-07 | 北京福纳康生物技术有限公司 | Method for testing in-vitro oxidation resistance of antioxidant and application thereof |
| CN113197819A (en) * | 2021-04-21 | 2021-08-03 | 安婕妤化妆品科技股份有限公司 | Moisturizing antioxidant toning lotion and preparation method thereof |
| CN115607476B (en) * | 2022-10-21 | 2023-07-25 | 广东丸美生物技术股份有限公司 | Composition with moisturizing and antioxidation effects and application thereof |
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