CN113197819A - Moisturizing antioxidant toning lotion and preparation method thereof - Google Patents

Moisturizing antioxidant toning lotion and preparation method thereof Download PDF

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CN113197819A
CN113197819A CN202110429968.6A CN202110429968A CN113197819A CN 113197819 A CN113197819 A CN 113197819A CN 202110429968 A CN202110429968 A CN 202110429968A CN 113197819 A CN113197819 A CN 113197819A
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skin
antioxidant
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moisturizing
lotion
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石毛
林志隆
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ANGLEE COSMETIC TECHNOLOGY CO LTD
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ANGLEE COSMETIC TECHNOLOGY CO LTD
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9717Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The invention belongs to the field of cosmetics and discloses moisturizing and antioxidant toning lotion and a preparation method thereof. The moisturizing antioxidant toning lotion comprises the following components in percentage by mass: 5 to 15 percent of humectant, 0.001 to 0.5 percent of antioxidant, 0.001 to 1 percent of skin conditioner, 0.001 to 0.2 percent of freshener and 0.01 to 0.2 percent of anti-allergy agent. The moisturizing antioxidant toning lotion provided by the invention can deeply lock the moisture of the skin and keep the moisture of the skin for a long time, so that the moisture content and the moisture degree of the skin are kept for a long time, and dry lines and the elasticity of the skin are improved to moisten the skin; the skin aging problem caused by oxidation can be improved, the skin darkness is obviously improved, the skin transparency is improved, the skin compactness is improved, and the skin is smooth and elastic, so that the purpose of resisting oxidation of the skin is achieved; the moisturizing and antioxidant cosmetic provided by the invention is mild in water, free of stimulation and easy to absorb.

Description

Moisturizing antioxidant toning lotion and preparation method thereof
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to moisturizing and antioxidant toning lotion and a preparation method thereof.
Background
With the improvement of living standard of the substance, people pay more and more attention to skin care, and the cost in the aspect is also more and more. Skin aging is a progressive physiological process and is also the result of the combined action of various factors such as genetics, environment, psychology and the like. However, due to the reasons of fast pace of life, increased biochemical pressure, irregular work and rest, improper use of skin care products and the like, more and more young people have aging symptoms such as laxity, wrinkles, color spots and the like on the skin, and are not aged before.
Basic care of the skin has become a part of daily life. The basic skin care mainly comprises three steps of cleaning, activating and caring skin, and is called as daily care tribulus terrestris. The toning lotion can quickly supplement the moisture of the stratum corneum of the skin, so that the toning lotion becomes a key step of the three-part yeast for starting and ending. However, the effect of the currently used astringent is not ideal enough, and the effect purpose is not clear enough, so people very need the astringent which has the effects of moisturizing, moisturizing and resisting oxidation, has clear effect, various and safe action routes and no adverse reaction.
Disclosure of Invention
The first aspect of the invention aims to provide moisturizing antioxidant toning lotion.
In a second aspect of the present invention, there is provided a method for preparing the moisturizing and antioxidant astringent of the first aspect.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
in a first aspect of the invention, the moisturizing antioxidant toning lotion comprises the following components in percentage by mass: 5 to 15 percent of humectant, 0.001 to 0.5 percent of antioxidant, 0.001 to 1 percent of skin conditioner, 0.001 to 0.2 percent of freshener and 0.01 to 0.2 percent of anti-allergy agent.
Preferably, the moisturizing and antioxidant toning lotion comprises the following components in percentage by mass: 10.506-13% of humectant, 0.01-0.2% of antioxidant, 0.005-0.6% of skin conditioner, 0.02-0.1% of freshener and 0.05-0.15% of anti-allergy agent.
Preferably, the moisturizing antioxidant toner further comprises: thickening agent, emulsifier, pH regulator, preservative, colorant and essence.
Preferably, the content of the thickening agent is 0.005-0.5% by mass; further 0.02 to 0.3 percent.
Preferably, the content of the emulsifier is 0.08-0.5% by mass percent; further 0.3 to 0.4 percent.
Preferably, the content of the pH regulator is 0.001-0.1% by mass; further 0.02 to 0.5 percent.
Preferably, the content of the preservative, the coloring agent and the essence is proper, and the preservative, the coloring agent and the essence meet relevant regulations of China, industry and the like.
Preferably, the content of the preservative is 0.2-0.8% by mass; further 0.25 to 0.66 percent.
Preferably, the content of the colorant is 0.001 to 0.5 percent by mass; further 0.003 to 0.15 percent.
Preferably, the content of the essence is 0.001-0.15% by mass percent; further 0.011 percent to 0.1 percent.
Preferably, the moisturizing antioxidant lotion further comprises water; the balance of the water is used.
Preferably, the humectant is at least one of sodium PCA, hexylene glycol, dipropylene glycol, propylene glycol, glycerin, butylene glycol, sodium hyaluronate, hydrolyzed collagen, and hydrolyzed elastin; further comprises at least one of dipropylene glycol, propylene glycol, glycerin, butylene glycol, sodium hyaluronate, hydrolyzed collagen, and hydrolyzed elastin.
Preferably, the antioxidant is at least one of vitamin E, astaxanthin, canthaxanthin, lutein and olive (OLEA EUROPAEA) fruit water; further comprises olive (Olea EUROPAEA) fruit juice.
Preferably, the skin conditioner is at least one of extract of leaves/stems of Mimusops elengi (Myrothamnus FLABELLIFOLIA), extract of Coix LACRYMA-JOBI (Coix LACRYMA-JOBI), extract of hydrolyzed red algae, and extract of fruit of Citrus JUNOS (Citrus JUNOS); further comprises an extract of the fruit of Citrus JUNOS (Citrus JUNOS).
Preferably, the cooling agent is at least one of menthol, mono L-menthyl glutarate and lactic acid menthol ester; further menthol lactate.
Preferably, the anti-allergy agent is at least one of Ectoin (Ectoin), tetrandra root extract, crocus sativus extract, helichrysum sedative anti-allergy factor and dipotassium glycyrrhizinate; further is dipotassium glycyrrhizinate.
Preferably, the thickener is at least one of xanthan gum, cellulose and carbomer; further carbomer.
Preferably, the emulsifier is at least one of cocamidopropyl betaine, PEG-60 hydrogenated castor oil, PEG-40 hydrogenated castor oil, and PPG-26-Butaneth-26; further a mixture of PEG-40 hydrogenated castor oil and PPG-26-Butaneth-26.
Preferably, the pH adjuster is at least one of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, and arginine; further triethanolamine.
Preferably, the preservative is at least one of methyl hydroxybenzoate, phenoxyethanol, imidazolidinyl urea, caprylhydroxamic acid, propyl hydroxybenzoate, butyl hydroxybenzoate and methylchloroisothiazolinone; more preferably at least one of methylparaben, phenoxyethanol, imidazolidinyl urea, and propylparaben.
Preferably, the essence is at least one of rose essence, lavender essence, angelica essence, jasmine essence, peach essence and guava essence; further comprises at least one of rose essence, lavender essence and peach essence.
Preferably, the colorant is at least one of CI 17200, CI61565, and CI 42090; further CI 42090.
In a second aspect of the present invention, there is provided a method for preparing the moisturizing and antioxidant astringent of the first aspect, wherein a moisturizing agent, an antioxidant, a skin conditioner, a freshener, an anti-sensitivity agent, a thickener, an emulsifier, a pH adjuster, a preservative, an essence, a colorant and water are mixed to obtain the moisturizing and antioxidant astringent.
The invention has the beneficial effects that:
the moisturizing antioxidant toning lotion provided by the invention can deeply lock the moisture of the skin and keep the moisture of the skin for a long time, so that the moisture content and the moisture degree of the skin are kept for a long time, and dry lines and the elasticity of the skin are improved to moisten the skin; the skin aging problem caused by oxidation can be improved, the skin darkness is obviously improved, the skin transparency is improved, the skin compactness is improved, and the skin is smooth and elastic, so that the purpose of resisting oxidation of the skin is achieved; the moisturizing and antioxidant cosmetic provided by the invention is mild in water, free of stimulation and easy to absorb.
The preparation method of the moisturizing antioxidant toning lotion provided by the invention is simple, can be used for large-scale production, and has a wide market prospect.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
The starting materials used in the examples were prepared by conventional means or purchased from commercial sources, except as otherwise specified.
Examples and comparative examples
The formulations of the moisturizing antioxidant lotions of examples 1 to 4 and comparative examples 1 to 3 are shown in table 1.
The preparation method of the moisturizing and antioxidant astringent of the embodiments 1 to 4 is as follows:
mixing dipropylene glycol, propylene glycol, glycerol, hydrolyzed collagen (available from Yizhi HP in Taiwan), butanediol, sodium hyaluronate (available from Xifulida), hydrolyzed elastin (available from Ashilan), menthol lactate, olive (Olea EUROPAEA) fruit water (available from Ashilan), orange (Citrus JUNOS) fruit extract (available from Ashilan), dipotassium glycyrrhizinate, carbomer, triethanolamine, propyl hydroxybenzoate, methyl hydroxybenzoate, phenoxyethanol, imidazolidinyl urea, CI42090, and water, adding premixed PEG-40 hydrogenated castor oil \ PPG-26-butanol polyether-26 (available from Shanghai Senxin), and essence, and stirring.
The preparation method of the moisturizing antioxidant astringent of comparative example 1 was identical to the preparation method of the moisturizing antioxidant astringent of example 1 except that hydrolyzed elastin was not added.
The preparation method of the moisturizing antioxidant toner of comparative example 2 is identical to that of the moisturizing antioxidant toner of example 1 except that olive (OLEA EUROPAEA) fruit water is not added.
The preparation method of the moisturizing antioxidant astringent of comparative example 3 is identical to that of the moisturizing antioxidant astringent of example 1 except that hydrolyzed collagen is not added.
TABLE 1 formulas of moisturizing antioxidant lotions of examples 1 to 4 and comparative examples 1 to 3
Figure BDA0003031009150000031
Figure BDA0003031009150000041
Figure BDA0003031009150000051
Effects of the embodiment
1) Test of moisturizing Effect
Selecting 70 volunteers 18-35 of age and close in skin complexion, equally dividing into 7 groups, measuring the initial skin hydration degree (averaging) of each group of volunteers, respectively using the moisturizing antioxidant lotion of examples 1-4 and comparative examples 1-3, lasting for 4 weeks once a day, testing the skin hydration degree (averaging) of each group of volunteers, and evaluating the moisturizing effect of the moisturizing antioxidant lotion, wherein the test results are shown in table 2: the skin hydration degree is lower before the moisturizing antioxidant toning lotion is used, and the skin hydration degree is greatly improved after the moisturizing antioxidant toning lotion is used for 4 weeks, and can be improved by 18 at most; is superior to comparative examples 1 to 3.
TABLE 2 moisturizing effect of lotions of examples 1 to 4 and comparative examples 1 to 3
Example 1 Example 2 Example 3 Example 4 Comparative example 1 Comparative example 2 Comparative example 3
0 week 61 62 61 59 60 61 63
4 weeks 76 74 78 75 70 71 72
2) Test for antioxidant Effect
The lotions of examples 1 to 4 and comparative examples 1 to 3 were subjected to an antioxidant activity (AOA) test: the moisturizing antioxidant toning lotion is used as sample liquid. 1: 25 preparation of yolk suspension: egg yolk and an equal volume of Phosphate Buffer (PB) with pH 7.45 and a concentration of 0.1mol/L were used to prepare a mixture with a volume ratio of 1: 1, magnetically stirring for 10min, and diluting with PB to obtain a suspension with a volume ratio of 1: 25 of a yolk suspension; take 0.2mL of 1: 25 yolk suspension, 0.2mL of 25.0mmol/LFeSO4Adding the solution and 0.2mL of sample solution into a series of 10mL centrifuge tubes, supplementing to 2.0mL by PB, culturing at 37 ℃ for 24h, taking out, adding 0.5mL of trichloroacetic acid solution (TCA) with the mass fraction of 20%, shaking uniformly, adding 1.0mL of thiobarbituric acid solution (TBA) with the mass fraction of 0.8% after 10min, placing in a boiling water bath for 15min, cooling, centrifuging at the rotating speed of 2500r/min for 10min, taking supernatant, and measuring the absorbance value A at the wavelength of 532 nm; except that the control tube does not add the sample liquid, the other reagents are the same as the above, the measured absorbance is A0, the measurement is carried out 3 times in parallel, and the average value is taken. The blank tube was replaced with 2.0mL PB, and the inhibition rate of the sample solution on the lipid peroxidation of the yolk lipoproteins was: (A0-A)/A0X 100%, the test results (averaged) are shown in Table 3: the moisturizing antioxidant toning lotion provided by the embodiments 1 to 4 has an antioxidant effect superior to that of the comparative examples 1 to 3, and can greatly improve the antioxidant property of skin.
TABLE 3 antioxidative Effect of lotions of examples 1 to 4 and comparative examples 1 to 3
Figure BDA0003031009150000061
Note: antioxidant activity (AOA): AOA represents the coulomb consumption for 100g of the analyzed substance to be titrated.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (10)

1. A toning lotion comprises the following components in percentage by mass: 5 to 15 percent of humectant, 0.001 to 0.5 percent of antioxidant, 0.001 to 1 percent of skin conditioner, 0.001 to 0.2 percent of freshener and 0.01 to 0.2 percent of anti-allergy agent.
2. The lotion according to claim 1, characterized in that: the toning lotion comprises the following components in percentage by mass: 10.506-13% of humectant, 0.01-0.2% of antioxidant, 0.005-0.6% of skin conditioner, 0.02-0.1% of freshener and 0.05-0.15% of anti-allergy agent.
3. The lotion according to claim 1, characterized in that: the humectant is at least one of sodium PCA, hexanediol, dipropylene glycol, propylene glycol, glycerin, butylene glycol, sodium hyaluronate, hydrolyzed collagen and hydrolyzed elastin.
4. The lotion according to claim 1, characterized in that: the antioxidant is at least one of vitamin E, astaxanthin, canthaxanthin, lutein and olive fruit water.
5. The lotion according to claim 1, characterized in that: the skin conditioner is at least one of folium Meliloti officinalis/stem extract, Coicis semen extract, hydrolyzed red algae extract and fructus Citri Junoris extract.
6. The lotion according to claim 1, characterized in that: the cooling agent is at least one of menthol, glutaric acid mono-L-menthyl ester and menthol lactate.
7. The lotion according to claim 1, characterized in that: the anti-allergy agent is at least one of ectoin, tetrandra root extract, crocus sativus extract, helichrysum sedative anti-allergy factor and dipotassium glycyrrhizinate.
8. A astringent according to any one of claims 1 to 7, wherein:
the lotion further comprises: thickening agent, emulsifier, pH regulator, preservative, colorant and essence.
9. The lotion according to claim 8, characterized in that:
the thickening agent is at least one of xanthan gum, cellulose and carbomer;
preferably, the emulsifier is at least one of cocamidopropyl betaine, PEG-60 hydrogenated castor oil, PEG-40 hydrogenated castor oil, and PPG-26-Butaneth-26;
preferably, the pH adjuster is at least one of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, and arginine;
preferably, the preservative is at least one of methylparaben, phenoxyethanol, imidazolidinyl urea, caprylhydroxamic acid, propylparaben, butylparaben and methylchloroisothiazolinone.
10. The method of producing a cosmetic water according to claim 8 or 9, wherein a humectant, an antioxidant, a skin conditioner, a cooling agent, an anti-allergy agent, a thickener, an emulsifier, a pH adjuster, a preservative, an essence, a coloring agent and water are mixed to obtain a cosmetic water.
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CN106265348A (en) * 2016-09-19 2017-01-04 广东丸美生物技术股份有限公司 A kind of substrate with maintenance skin barrier and senile-resistant efficacy and its preparation method and application
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