CN114588060A - Whitening and moisturizing mask with acne removing effect and preparation method thereof - Google Patents
Whitening and moisturizing mask with acne removing effect and preparation method thereof Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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Abstract
The invention discloses a preparation method of a whitening and moisturizing mask with acne removing efficacy, which comprises the following steps of S1: the method for extracting madecassoside from centella asiatica comprises the following steps of S1-1: crushing centella, and degreasing with a degreasing agent under an ultrasonic condition to obtain degreased centella; s1-2: dispersing the extract in an extraction liquid, and extracting madecassoside to obtain an extraction mixture; s1-3: performing solid-liquid separation, taking out liquid part, standing, and collecting lower phase liquid rich in madecassoside; s1-4: introducing into resin column for chromatography, and purifying and extracting to obtain the madecassoside. The facial mask prepared by the invention has good whitening and moisturizing effects and outstanding acne removing effects, and active ingredients in the facial mask are slowly released and permeate into skin hair follicles, so that the problems of dryness, dullness, acne and the like of the skin are effectively improved.
Description
Technical Field
The invention relates to the technical field of skin care masks, and particularly relates to a whitening and moisturizing mask with an acne removing effect and a preparation method thereof.
Background
With the increasing improvement of living standard of people and the continuous increase of skin care demand, the appearance of facial masks is continuously concerned by people. The facial mask can increase the temperature of the surface of the skin in a relatively closed space to expand pores, so that active ingredients of the facial mask can permeate into the skin, and the problems of dryness, dullness, multiple acnes and the like of the skin are solved.
Centella asiatica is also called centella asiatica, centella asiatica and centella asiatica, and is a whole plant of centella asiatica of Umbelliferae. The natural medicine centella has strong effects of promoting wound healing and skin repair. Centella asiatica has complex chemical components, and mainly comprises triterpenes, flavonoids, volatile oils, polyacetylenes and the like. It is currently believed that the major active ingredients of centella asiatica include asiaticoside B, madecassoside and asiaticoside; the effect of centella asiatica is the content of asiaticoside and madecassoside. Studies show that the effect of the madecassoside is obviously stronger than that of the asiaticoside, wherein the madecassoside and the asiaticoside B are a pair of isomers which have only one more hydroxyl group compared with the asiaticoside, and the connection of the glycounits with strong polarity greatly weakens the difference of tiny polarities, so that the three substances are difficult to be completely separated by using a conventional separation method.
Disclosure of Invention
In view of the defects of the prior art, the invention provides a whitening and moisturizing mask with acne removing efficacy and a preparation method thereof, and aims to solve the problem that the acne removing efficacy of the mask is reduced due to the fact that madecassoside added in the existing mask is difficult to separate and purify from centella asiatica.
In order to achieve the above purposes, the technical scheme adopted by the invention is as follows:
a preparation method of a whitening and moisturizing mask with an acne removing effect comprises the following steps of S1: the method for extracting the madecassoside from the centella asiatica comprises the following steps:
s1-1: crushing centella, and degreasing with a degreasing agent under an ultrasonic condition to obtain degreased centella;
s1-2: dispersing the degreased centella asiatica obtained in the step S1-1 in a two-aqueous-phase extraction system, and extracting madecassoside to obtain an extraction mixture;
s1-3: carrying out solid-liquid separation on the extraction mixture obtained in the step S1-2, taking a liquid part, standing, and collecting a lower phase liquid rich in madecassoside;
s1-4: and (4) introducing the lower phase liquid obtained in the step (S1-3) into a resin column for chromatography, and purifying and extracting to obtain the madecassoside.
Preferably, the method for preparing the mask further includes step S2: dissolving 3 parts by weight of the madecassoside obtained in the step S1-4 in 20 parts by weight of a polyethylene glycol aqueous solution to serve as an internal water phase; adding the internal water phase into 57 parts by weight of 1, 2-propylene glycol solution of polylactic-co-glycolic acid, setting the solution temperature at 20 ℃, and magnetically stirring to obtain W/O emulsion; dissolving 2 parts by weight of sodium alginate and 2.5 parts by weight of xanthan gum in 15 parts by weight of deionized water to obtain an external water phase; slowly adding the W/O emulsion into the external water phase, setting the temperature to be 20 ℃, magnetically stirring for 30min, and adding 0.5 part by weight of polyvinyl alcohol to obtain W/O/W multiple emulsion; refrigerating at 4 deg.C for 24 hr to obtain the modified madecassoside gel. The application wraps up madecassoside in the compound milk of W/O/W for madecassoside can slowly release and go deep into the skin hair follicle, has prolonged the effect of madecassoside to the skin acne removal for a long time, has further improved the effect of skin acne removal.
Preferably, the method for preparing the mask further includes step S3: weighing 0.5-5 parts of the modified madecassoside gel obtained in the step S2, 1.5-5.5 parts of nano activated carbon, 5-30 parts of humectant, 0.1-1 part of arbutin, 0.01-1 part of radix ampelopsis extract, 0.01-1 part of rhizoma atractylodis macrocephalae rhizome extract, 0.03-3 parts of cortex mori extract, 0.05-5 parts of rhizoma nardostachyos extract, 0.01-1 part of aloe extract, 0.01-1 part of radix ophiopogonis extract, 0.01-1 part of radix sophorae flavescentis extract, 0.01-0.3 part of chelating agent, 0.01-1 part of solubilizer, 0.01-1 part of preservative, 0.01-1 part of thickener, 0.01-0.1 part of citric acid and 80-100 parts of deionized water, uniformly stirring and mixing in a water bath at 35-45 ℃, and cooling to obtain the mask. According to the facial mask, the madecassoside is compounded with other active ingredients in a gel manner, so that the active ingredients of the madecassoside can be slowly released, and the effects of whitening skin can be effectively achieved by combining various plant extracts such as arbutin, cortex mori radicis, aloe and the like; the addition of the nano activated carbon has a synergistic effect of skin cleaning, and the skin care effect of the facial mask is improved through dual physical and biological effects.
Preferably, the degreasing agent is at least one of methanol, ethanol, propanol and propylene glycol.
Preferably, the aqueous two-phase extraction system is obtained by compounding pyridine ionic liquid, phosphate buffer solution, anionic surfactant and deionized water. The application of the double-aqueous-phase extraction system is characterized in that the double-aqueous-phase extraction system added with pyridine ionic liquid is cooperated with a double-aqueous-phase system combined by phosphate buffer solution, anionic surfactant and deionized water to extract the active ingredient of madecassoside from the degreased centella asiatica in a green color and high efficiency manner.
Preferably, the mass ratio of the pyridine ionic liquid to the phosphate buffer solution to the anionic surfactant to the deionized water is 3-3.5: 1-2: 0.5-1: 15 to 25.
Preferably, the pyridine ionic liquid is N-sulfonic acid butyl pyridine p-toluene sulfonate or N-sulfonic acid propyl pyridine p-toluene sulfonate.
Preferably, the anionic surfactant is polyoxyethylene isostearyl phosphate potassium salt or alkylphenyl polyoxyethylene ether sulfonate.
Preferably, the phosphate buffer is at least one of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate and dipotassium hydrogen phosphate.
The invention has the beneficial effects that:
the invention adopts a two-aqueous phase extraction system for extraction operation, has simple operation and mild conditions, can not cause activity damage to the active component madecassoside due to high-temperature operation, and the purity of the madecassoside in the extracted extract reaches 99.0 percent, and the content of the asiaticoside B, the asiaticoside and other components is low.
The facial mask prepared by the invention has good whitening and moisturizing effects and outstanding acne removing effects, and active ingredients in the facial mask are slowly released and permeate into skin hair follicles, so that the problems of dryness, dullness, acne and the like of the skin are effectively improved.
Detailed Description
The following description is presented to disclose the invention so as to enable any person skilled in the art to practice the invention. The preferred embodiments in the following description are given by way of example only, and other obvious variations will occur to those skilled in the art.
Example 1
The preparation method of the whitening and moisturizing mask with the acne removing effect of the embodiment comprises the following steps of S1: the method for extracting the madecassoside from the centella asiatica comprises the following steps:
s1-1: crushing centella asiatica, taking 10g of the crushed centella asiatica of 300 meshes, degreasing the 10g of the crushed centella asiatica with 100g of methanol under the ultrasonic condition of 500W power, and removing a degreasing agent after ultrasonic operation is carried out for 30min to obtain degreased centella asiatica;
s1-2: dispersing 7g of the degreased asiatic pennywort herb obtained in the step S1-1 in 31g of a two-aqueous-phase extraction system, and extracting madecassoside to obtain an extraction mixture; the aqueous two-phase extraction system comprises a mixture of 3: 1: 0.5: 15, N-butyl pyridine sulfonate p-toluenesulfonate, sodium dihydrogen phosphate, polyoxyethylene isostearyl ether phosphate potassium salt and deionized water;
s1-3: carrying out solid-liquid separation on the extraction mixture obtained in the step S1-2, taking a liquid part, standing for 24 hours, and collecting a lower phase liquid rich in madecassoside;
s1-4: and (4) introducing the lower phase liquid obtained in the step (S1-3) into a resin column for chromatography, and purifying and extracting to obtain the madecassoside. An ethanol-water system is adopted as an eluent in the chromatography process. The content of the madecassoside is 99.2% by chromatographic analysis.
The preparation method of the mask further comprises the step of S2: dissolving 3 parts by weight of the madecassoside obtained in the step S1-4 in 20 parts by weight of a polyethylene glycol aqueous solution (the mass concentration of polyethylene glycol is 3.2%, the same applies below) as an internal aqueous phase; adding 57 parts by weight of the internal water phase into 1, 2-propylene glycol solution of the polylactic-co-glycolic acid (the mass concentration of the polylactic-co-glycolic acid is 1.5%, the same applies below), setting the solution temperature at 20 ℃, and performing magnetic stirring to obtain W/O emulsion; dissolving 2 parts by weight of sodium alginate and 2.5 parts by weight of xanthan gum in 15 parts by weight of deionized water to obtain an external water phase; slowly adding the W/O emulsion into the external water phase, setting the temperature to be 20 ℃, magnetically stirring for 30min, and adding 0.5 part by weight of polyvinyl alcohol to obtain W/O/W multiple emulsion; refrigerating at 4 deg.C for 24 hr to obtain the modified madecassoside gel.
The preparation method of the mask further comprises the step of S3: weighing 0.5 part of the modified madecassoside gel obtained in the step S2, 1.5 parts of nano activated carbon, 5 parts of humectant, 0.1 part of arbutin, 0.1 part of radix ampelopsis extract, 0.1 part of rhizoma atractylodis macrocephalae rhizome extract, 0.3 part of cortex mori extract, 0.05 part of rhizoma nardostachyos extract, 0.1 part of aloe extract, 0.02 part of radix ophiopogonis extract, 0.05 part of radix sophorae flavescentis extract, 0.1 part of chelating agent, 0.2 part of solubilizer, 0.05 part of preservative, 0.1 part of thickener, 0.03 part of citric acid and 80 parts of deionized water, stirring and mixing uniformly in a water bath at 35 ℃, and cooling to obtain the mask. The humectant is prepared from the following components in percentage by mass: 1 glucose and amino acids; the chelating agent is EDTA disodium; the solubilizer is PEG-40 hydrogenated castor oil; the preservative is methylisothiazolinone; the thickener is hydroxyethyl cellulose.
Example 2
The preparation method of the whitening and moisturizing mask with the acne removing effect of the embodiment comprises the following steps of S1: the method for extracting the madecassoside from the centella asiatica comprises the following steps:
s1-1: crushing centella asiatica, taking 10g of the crushed centella asiatica of 300 meshes, degreasing the 10g of the crushed centella asiatica with 100g of ethanol under the ultrasonic condition of 500W power, and removing a degreasing agent after ultrasonic operation is carried out for 30min to obtain degreased centella asiatica;
s1-2: dispersing 7g of the degreased asiatic pennywort herb obtained in the step S1-1 in 31g of a two-aqueous-phase extraction system, and extracting madecassoside to obtain an extraction mixture; the aqueous two-phase extraction system comprises a mixture of 3.2: 1.5: 0.7: 20 of N-sulfopropyl pyridine p-toluenesulfonate, disodium hydrogen phosphate, alkyl phenyl polyoxyethylene ether sulfonate and deionized water;
s1-3: carrying out solid-liquid separation on the extraction mixture obtained in the step S1-2, taking a liquid part, standing for 24 hours, and collecting a lower phase liquid rich in madecassoside;
s1-4: and (4) introducing the lower phase liquid obtained in the step (S1-3) into a resin column for chromatography, and purifying and extracting to obtain the madecassoside. An ethanol-water system is adopted as an eluent in the chromatography process. The content of the madecassoside is 99.1% by chromatographic analysis.
The preparation method of the mask further comprises the step of S2: dissolving 3 parts by weight of the madecassoside obtained in the step S1-4 in 20 parts by weight of a polyethylene glycol aqueous solution to serve as an internal water phase; adding the internal water phase into 57 parts by weight of 1, 2-propylene glycol solution of polylactic-co-glycolic acid, setting the solution temperature at 20 ℃, and magnetically stirring to obtain W/O emulsion; dissolving 2 parts by weight of sodium alginate and 2.5 parts by weight of xanthan gum in 15 parts by weight of deionized water to obtain an external water phase; slowly adding the W/O emulsion into the external water phase, setting the temperature to be 20 ℃, magnetically stirring for 30min, and adding 0.5 part by weight of polyvinyl alcohol to obtain W/O/W multiple emulsion; refrigerating at 4 deg.C for 24 hr to obtain the modified madecassoside gel.
The preparation method of the mask further comprises the step of S3: weighing 3 parts of the modified madecassoside gel obtained in the step S2, 3.5 parts of nano activated carbon, 15 parts of humectant, 0.6 part of arbutin, 0.5 part of radix ampelopsis extract, 0.4 part of rhizoma atractylodis macrocephalae extract, 1 part of cortex mori extract, 1.5 parts of rhizoma nardostachyos extract, 0.2 part of aloe extract, 0.3 part of radix ophiopogonis extract, 0.7 part of radix sophorae flavescentis extract, 0.1 part of chelating agent, 0.3 part of solubilizer, 0.2 part of preservative, 0.6 part of thickener, 0.03 part of citric acid and 90 parts of deionized water in parts by weight, stirring and mixing uniformly in a water bath at 40 ℃, and cooling to obtain the mask. The humectant, chelating agent, solubilizer, preservative and thickener were the same as in example 1.
Example 3
The preparation method of the whitening and moisturizing mask with the acne removing effect of the embodiment comprises the following steps of S1: the method for extracting the madecassoside from the centella asiatica comprises the following steps:
s1-1: crushing centella asiatica, taking 10g of the crushed centella asiatica of 300 meshes, degreasing the 10g of the crushed centella asiatica with 100g of propanol under the ultrasonic condition of 500W power, and removing a degreasing agent after ultrasonic operation is carried out for 30min to obtain degreased centella asiatica;
s1-2: dispersing 7g of the degreased asiatic pennywort herb obtained in the step S1-1 in 31g of a two-aqueous-phase extraction system, and extracting madecassoside to obtain an extraction mixture; the aqueous two-phase extraction system comprises a mixture of 3.5: 2: 1: 25 of N-sulfonic acid butyl pyridine p-toluenesulfonate, potassium dihydrogen phosphate, polyoxyethylene isostearyl ether phosphate potassium salt and deionized water;
s1-3: carrying out solid-liquid separation on the extraction mixture obtained in the step S1-2, taking a liquid part, standing for 24 hours, and collecting a lower phase liquid rich in madecassoside;
s1-4: and (4) introducing the lower phase liquid obtained in the step (S1-3) into a resin column for chromatography, and purifying and extracting to obtain the madecassoside. An ethanol-water system is adopted as an eluent in the chromatography process. The content of the madecassoside is 99.1% by chromatographic analysis.
The preparation method of the mask further comprises the step of S2: dissolving 3 parts by weight of the madecassoside obtained in the step S1-4 in 20 parts by weight of a polyethylene glycol aqueous solution to serve as an internal water phase; adding the internal water phase into 57 parts by weight of 1, 2-propylene glycol solution of polylactic-co-glycolic acid, setting the solution temperature at 20 ℃, and magnetically stirring to obtain W/O emulsion; dissolving 2 parts by weight of sodium alginate and 2.5 parts by weight of xanthan gum in 15 parts by weight of deionized water to obtain an external water phase; slowly adding the W/O emulsion into the external water phase, setting the temperature to be 20 ℃, magnetically stirring for 30min, and adding 0.5 part by weight of polyvinyl alcohol to obtain W/O/W multiple emulsion; refrigerating at 4 deg.C for 24 hr to obtain the modified madecassoside gel.
The preparation method of the mask further comprises the step of S3: weighing 5 parts of the modified madecassoside gel obtained in the step S2, 5.5 parts of nano activated carbon, 30 parts of humectant, 1 part of bearberry, 1 part of radix ampelopsis extract, 0.8 part of rhizoma atractylodis macrocephalae rhizome extract, 1.6 parts of cortex mori radicis extract, 2.1 parts of rhizoma nardostachyos extract, 0.8 part of aloe extract, 0.5 part of radix ophiopogonis extract, 1 part of radix sophorae flavescentis extract, 0.3 part of chelating agent, 0.6 part of solubilizer, 0.7 part of preservative, 1 part of thickener, 0.6 part of citric acid and 100 parts of deionized water, stirring and mixing uniformly in a water bath at 45 ℃, and cooling to obtain the mask. The humectants, chelating agents, solubilizers, preservatives, and thickeners were the same as in example 1.
Comparative example 1
The preparation method of the whitening and moisturizing mask with the acne removing effect in the comparative example is basically the same as that in example 1, except that in the preparation method in the comparative example, N-butylpyridinium sulfonate p-toluenesulfonate is not added in the aqueous two-phase extraction system, and the whitening and moisturizing mask is obtained by compounding sodium dihydrogen phosphate, polyoxyethylene isostearyl ether phosphate potassium salt and deionized water.
Comparative example 2
The preparation method of the whitening and moisturizing mask with the acne removing effect in the comparative example is basically the same as that in example 1, except that in the preparation method in the comparative example, the aqueous two-phase extraction system is obtained by compounding a quaternary ammonium salt cationic surfactant (n-hexadecyl trimethyl ammonium bromide) instead of polyoxyethylene isostearyl ether phosphate potassium salt.
Comparative example 3
The preparation method of the whitening and moisturizing mask with acne removing efficacy in the comparative example is basically the same as that in example 1, except that in the preparation method of the comparative example, step S2 is omitted, and madecassoside extracted in step S1 is directly added to step S3.
The facial masks prepared in the embodiments 1-3 and the comparative examples 1-3 are used as test samples, and during the test, the face is firstly cleaned and wiped dry without any skin care product; then, taking a proper amount of milky facial mask prepared in the examples 1-3 and the comparative examples 1-3, mixing with warm water, uniformly coating the milky facial mask on a patient with facial greasy skin, wherein the facial mask is affected by papules, pustules, nodules, cysts, scars and other various damages on the face, and staying for thirty minutes three times per week. The complete disappearance of symptoms is taken as an evaluation standard for the healing of the acne, the obvious improvement or the improvement of the symptoms is taken as an evaluation standard for the effectiveness of the acne, and the no improvement of the symptoms is taken as an evaluation standard for the ineffectiveness of the acne. According to the diagnosis standard, 60 patients who are diagnosed are respectively applied with facial mask samples, and the treatment effect is counted after 3 months, and the statistical result is shown in table 1:
TABLE 1
In addition, 60 female test volunteers with healthy skin and no allergic history of skin diseases are found, and the female test volunteers are 20-40 years old and randomly divided into 6 groups of 10 persons. The facial masks prepared in the examples 1-3 and the comparative examples 1-3 are used as test samples, and during the test, the face is cleaned firstly and is wiped dry without any skin care product; then, a proper amount of milky facial mask prepared in the examples 1-3 and the comparative examples 1-3 is taken, mixed with warm water, uniformly applied to the face, kept for thirty minutes and three times per week. The evaluation indexes comprise mildness, comfort, water wetness, refreshing feeling and whitening effect, the evaluation index is 10 points, the higher the score is, the better the effect is, and the arithmetic mean value is adopted for statistics. And (3) counting the skin care effect after 3 months, wherein the counting result is shown in a table 2:
TABLE 2
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed.
Claims (10)
1. The preparation method of the whitening and moisturizing mask with the acne removing effect is characterized by comprising the following steps of S1: the method for extracting the madecassoside from the centella asiatica comprises the following steps:
s1-1: crushing centella, and degreasing with a degreasing agent under an ultrasonic condition to obtain degreased centella;
s1-2: dispersing the degreased centella asiatica obtained in the step S1-1 in a two-aqueous-phase extraction system, and extracting madecassoside to obtain an extraction mixture;
s1-3: carrying out solid-liquid separation on the extraction mixture obtained in the step S1-2, taking a liquid part, standing, and collecting a lower phase liquid rich in madecassoside;
s1-4: and (4) introducing the lower phase liquid obtained in the step (S1-3) into a resin column for chromatography, and purifying and extracting to obtain the madecassoside.
2. The method of preparing a whitening and moisturizing mask with acne removal efficacy according to claim 1, wherein the method of preparing the mask further comprises the step of S2: dissolving 3 parts by weight of the madecassoside obtained in the step S1-4 in 20 parts by weight of a polyethylene glycol aqueous solution to serve as an internal water phase; adding the internal water phase into 57 parts by weight of 1, 2-propylene glycol solution of polylactic-co-glycolic acid, setting the solution temperature at 20 ℃, and magnetically stirring to obtain W/O emulsion; dissolving 2 parts by weight of sodium alginate and 2.5 parts by weight of xanthan gum in 15 parts by weight of deionized water to obtain an external water phase; slowly adding the W/O emulsion into the external water phase, setting the temperature to be 20 ℃, magnetically stirring for 30min, and adding 0.5 part by weight of polyvinyl alcohol to obtain W/O/W multiple emulsion; refrigerating at 4 deg.C for 24 hr to obtain the modified madecassoside gel.
3. The method of preparing a whitening and moisturizing mask with acne removal efficacy according to claim 2, further comprising the step of S3: weighing 0.5-5 parts of the modified madecassoside gel obtained in the step S2, 1.5-5.5 parts of nano activated carbon, 5-30 parts of humectant, 0.1-1 part of arbutin, 0.01-1 part of radix ampelopsis extract, 0.01-1 part of rhizoma atractylodis macrocephalae rhizome extract, 0.03-3 parts of cortex mori extract, 0.05-5 parts of rhizoma nardostachyos extract, 0.01-1 part of aloe extract, 0.01-1 part of radix ophiopogonis extract, 0.01-1 part of radix sophorae flavescentis extract, 0.01-0.3 part of chelating agent, 0.01-1 part of solubilizer, 0.01-1 part of preservative, 0.01-1 part of thickener, 0.01-0.1 part of citric acid and 80-100 parts of deionized water, uniformly stirring and mixing in a water bath at 35-45 ℃, and cooling to obtain the mask.
4. The method for preparing a whitening and moisturizing mask with acne removing efficacy according to claim 1, wherein the degreasing agent is at least one of methanol, ethanol, propanol and propylene glycol.
5. The method for preparing a whitening and moisturizing mask with an acne removing effect according to claim 1, wherein the aqueous two-phase extraction system is prepared by compounding pyridine ionic liquid, phosphate buffer, anionic surfactant and deionized water.
6. The preparation method of the whitening and moisturizing mask with the acne removing effect according to claim 5, wherein the mass ratio of the pyridine ionic liquid to the phosphate buffer solution to the anionic surfactant to the deionized water is 3-3.5: 1-2: 0.5-1: 15 to 25.
7. The method for preparing a whitening and moisturizing mask with acne removal efficacy according to claim 5, wherein the pyridine ionic liquid is N-sulfobutyl pyridine p-toluenesulfonate or N-sulfopropyl pyridine p-toluenesulfonate.
8. The method of preparing a whitening and moisturizing mask with an acne removing effect according to claim 5, wherein the anionic surfactant is polyoxyethylene isostearyl phosphate potassium salt or alkyl phenyl polyoxyethylene ether sulfonate.
9. The method of preparing a whitening and moisturizing mask with acne removing efficacy according to claim 5, wherein the phosphate buffer is at least one of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, and dipotassium hydrogen phosphate.
10. The whitening and moisturizing mask with the acne removing effect is characterized by being prepared by the preparation method according to any one of claims 1-9.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210452915.0A CN114588060A (en) | 2022-04-27 | 2022-04-27 | Whitening and moisturizing mask with acne removing effect and preparation method thereof |
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| CN202210452915.0A CN114588060A (en) | 2022-04-27 | 2022-04-27 | Whitening and moisturizing mask with acne removing effect and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300428A (en) * | 2022-08-19 | 2022-11-08 | 完美（广东）日用品有限公司 | Centella asiatica extract and preparation method and application thereof |
| CN115944551A (en) * | 2023-01-19 | 2023-04-11 | 麦吉丽生物科技有限公司 | Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence |
-
2022
- 2022-04-27 CN CN202210452915.0A patent/CN114588060A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300428A (en) * | 2022-08-19 | 2022-11-08 | 完美（广东）日用品有限公司 | Centella asiatica extract and preparation method and application thereof |
| CN115944551A (en) * | 2023-01-19 | 2023-04-11 | 麦吉丽生物科技有限公司 | Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence |
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Application publication date: 20220607 |