CN115944551A - Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence - Google Patents
Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence Download PDFInfo
- Publication number
- CN115944551A CN115944551A CN202310058302.3A CN202310058302A CN115944551A CN 115944551 A CN115944551 A CN 115944551A CN 202310058302 A CN202310058302 A CN 202310058302A CN 115944551 A CN115944551 A CN 115944551A
- Authority
- CN
- China
- Prior art keywords
- essence
- acne
- composition
- effects
- controlling oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010000496 acne Diseases 0.000 title claims abstract description 122
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 119
- 230000000694 effects Effects 0.000 title claims abstract description 62
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 208000020154 Acnes Diseases 0.000 claims abstract description 32
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 24
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000011701 zinc Substances 0.000 claims abstract description 21
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 21
- 239000002537 cosmetic Substances 0.000 claims abstract description 19
- 238000000855 fermentation Methods 0.000 claims abstract description 18
- 230000004151 fermentation Effects 0.000 claims abstract description 18
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 claims abstract description 16
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 claims abstract description 16
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940090813 madecassoside Drugs 0.000 claims abstract description 16
- 239000003755 preservative agent Substances 0.000 claims abstract description 15
- 239000002562 thickening agent Substances 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000011159 matrix material Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 9
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 11
- 239000011259 mixed solution Substances 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000009736 wetting Methods 0.000 claims description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 4
- 229940048053 acrylate Drugs 0.000 claims description 4
- 229920006037 cross link polymer Polymers 0.000 claims description 4
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 claims description 4
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 3
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 3
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 2
- 244000215068 Acacia senegal Species 0.000 claims description 2
- 229920000936 Agarose Polymers 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 229940114077 acrylic acid Drugs 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229940047670 sodium acrylate Drugs 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 229940043375 1,5-pentanediol Drugs 0.000 claims 1
- XMLSXPIVAXONDL-PLNGDYQASA-N Jasmone Chemical compound CC\C=C/CC1=C(C)CCC1=O XMLSXPIVAXONDL-PLNGDYQASA-N 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229940113120 dipropylene glycol Drugs 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 229940051250 hexylene glycol Drugs 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- FJXWKBZRTWEWBJ-UHFFFAOYSA-N nonanediamide Chemical compound NC(=O)CCCCCCCC(N)=O FJXWKBZRTWEWBJ-UHFFFAOYSA-N 0.000 claims 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims 1
- XMLSXPIVAXONDL-UHFFFAOYSA-N trans-jasmone Natural products CCC=CCC1=C(C)CCC1=O XMLSXPIVAXONDL-UHFFFAOYSA-N 0.000 claims 1
- 239000011148 porous material Substances 0.000 abstract description 3
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000008591 skin barrier function Effects 0.000 abstract description 3
- 239000000686 essence Substances 0.000 description 42
- 210000003491 skin Anatomy 0.000 description 33
- 239000000306 component Substances 0.000 description 28
- 238000012360 testing method Methods 0.000 description 28
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 11
- 206010061218 Inflammation Diseases 0.000 description 10
- 230000004054 inflammatory process Effects 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 230000002195 synergetic effect Effects 0.000 description 6
- 206010015150 Erythema Diseases 0.000 description 5
- 231100000321 erythema Toxicity 0.000 description 5
- 230000037380 skin damage Effects 0.000 description 5
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 4
- 206010040914 Skin reaction Diseases 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 231100000430 skin reaction Toxicity 0.000 description 4
- 230000035483 skin reaction Effects 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 210000001732 sebaceous gland Anatomy 0.000 description 3
- 206010040882 skin lesion Diseases 0.000 description 3
- 231100000444 skin lesion Toxicity 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 241000186427 Cutibacterium acnes Species 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 2
- 230000003255 anti-acne Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- ZNJFBWYDHIGLCU-HWKXXFMVSA-N jasmonic acid Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-HWKXXFMVSA-N 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000037312 oily skin Effects 0.000 description 2
- 229940055019 propionibacterium acne Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- VEDNSEZGQMNNER-UHFFFAOYSA-N 9-(2-hydroxyethylamino)-9-oxononanoic acid Chemical compound OCCNC(=O)CCCCCCCC(O)=O VEDNSEZGQMNNER-UHFFFAOYSA-N 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 244000148064 Enicostema verticillatum Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 206010027626 Milia Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000004900 autophagic degradation Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- ZNJFBWYDHIGLCU-UHFFFAOYSA-N jasmonic acid Natural products CCC=CCC1C(CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-UHFFFAOYSA-N 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 210000002780 melanosome Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to the field of cosmetics, and particularly relates to a composition with oil control, acne removal and acne mark removal effects, essence and a preparation method thereof, wherein the composition with the oil control, acne removal and acne mark removal effects comprises the following components in percentage by mass (1-10): (0.1-1): (1-10): (0.001-0.005) nonanediamide-MEA, madecassoside, yeast/zinc fermentation product and polyquaternium-73. The essence comprises the following components in percentage by weight: 5-30% of composition with the effects of controlling oil, removing acnes and removing acne marks; 70-95% of cosmetic auxiliary material matrix; the cosmetic auxiliary material matrix comprises a humectant, a thickening agent, a preservative, a daily essence and deionized water. Compared with the prior art, the acne removing mask disclosed by the invention can open skin pores, adjust the water-oil balance of skin, remove acnes, fade acne marks, repair damaged skin, maintain the skin barrier function and solve the acne crisis in multiple directions.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to a composition and essence with effects of controlling oil, removing acnes and removing acne marks and a preparation method of the composition and essence.
Background
Clinically, acne is called "acne", which is a chronic inflammatory skin disease of the sebaceous gland of the hair follicle, and is also often called "whelk" because it occurs well in adolescence between men and women. Acne is characterized by a wide variety of manifestations, including blackhead, whitehead, pimple, and pustule, which are all complex sounds, and in fact, the manifestations of pox in different stages.
Whelk is already not only a standard prescription of teenagers, more and more 20+ and 30+ people are successively attacked by the whelk, the problem of the whelk is large in population base, the mask whelk is more attractive, the whelk is in an ascending trend, and the market heat of the whelk is continuously increased.
As a core component of acne-removing cosmetics, the selection of an acne-removing active ingredient is crucial, but is limited by formula application and national regulations on related ingredients and dosage, and commercially available acne-removing skin care products generally have the defects of single effective ingredient, slow response, unsatisfactory acne-removing effect and the like. How to search for an efficient and safe acne-removing active composition aiming at the physiological and pathological characteristics of acne skin is the direction of the cosmetic practitioners to be keen.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide the composition with the effects of controlling oil, removing acnes and acne marks, removing acne marks, repairing damaged skin, maintaining the barrier function of skin, and solving the acne crisis in multiple directions, and the preparation method and the application thereof.
The purpose of the invention can be realized by the following technical scheme: the composition with the effects of controlling oil, removing acnes and removing acne marks comprises the following components in percentage by mass: (1-10): (0.1-1): (1-10): (0.001-0.005) nonanediamide-MEA, madecassoside, yeast/zinc fermentation product and polyquaternium-73.
Further, the mass ratio of the azelaic acid amide-MEA to the madecassoside to the yeast/zinc fermentation product to the polyquaternium-73 is (2-8): (0.1-0.6): (1-6): (0.003-0.005). Further preferably, the mass ratio of the madecassoside, the yeast/zinc fermentation product, the azelaic diamide-MEA and the polyquaternium-73 is (0.1-0.5): (1-5): (3-5): (0.001-0.005); wherein the polyquaternium-73 is dissolved by butanediol before use, wherein the mass ratio of the polyquaternium-73 to the butanediol is (0.001-0.005): 5.
furthermore, the mass ratio of the azelaic acid amide-MEA to the madecassoside to the fermentation product of the yeast/zinc to the polyquaternium-73 is (3-5): (0.1-0.3): (4-5): (0.003-0.005).
Further, the yeast/zinc fermentation product is yeast essence Z20.
The invention also provides essence containing the composition with the effects of controlling oil, removing acnes and removing acne marks, which comprises the following components in percentage by weight:
5-30% of composition with the effects of controlling oil, removing acnes and removing acne marks;
70-95% of cosmetic auxiliary material matrix; the cosmetic auxiliary material matrix comprises a humectant, a thickening agent, a preservative, a daily essence and deionized water.
Further, the composition with the effects of controlling oil, removing acnes and removing acne marks comprises 1-10% of azelaic diamide-MEA (MEA), wherein the total mass of the raw materials for preparing the essence is 100%; 0.1-1% of madecassoside; 1-10% of yeast/zinc fermentation product; 0.001-0.005% of polyquaternium-73.
Further, the cosmetic auxiliary material matrix comprises the following components in percentage by mass of 100% of the total mass of the raw materials for preparing the essence: 0.2-35% of humectant; 0.2-1% of a thickening agent; 0.5-1% of preservative; 0.005-1% of essence for daily use; the balance being deionized water.
Further, the essence comprises:
5-20% of composition with the effects of controlling oil, removing acnes and removing acne marks;
80-95% of cosmetic auxiliary material matrix;
still further, the essence comprises:
7-20% of composition with the effects of controlling oil, removing acnes and removing acne marks;
80-93% of cosmetic auxiliary material matrix;
the composition with the effects of controlling oil, removing acnes and removing acne marks comprises the following components: 2-8% nonanediamide-MEA; 0.1-0.6% madecassoside; 1-6% yeast/zinc fermentation product; 0.003-0.005% of polyquaternium-73;
the cosmetic auxiliary material matrix comprises: 0.2-35% of humectant; 0.2-0.8% of a thickening agent; 0.5-1% of preservative; 0.005-1% of essence for daily use; the balance being deionized water.
Further, the humectant is selected from one or more of sodium hyaluronate, butanediol, hexanediol, pentanediol, glycerol and dipropylene glycol.
Further, the thickening agent is selected from one or more of carbomer, xanthan gum, acrylic acid/C10-30 alkanol acrylate cross-linked polymer, gum arabic, polymer EMT-10, sodium acrylate/sodium acryloyldimethyl taurate, acrylic acid/C10-30 alkanol acrylate cross-linked polymer copolymer, hydroxyethyl cellulose and agarose.
Further, the preservative is selected from one or more of phenoxyethanol, ethylhexyl glycerol, jasmonic acid, sodium benzoate, pentanediol and hexanediol.
The invention also provides a preparation method of the essence, which comprises the following steps:
1) Wetting and completely dispersing the thickening agent in water to obtain a mixed solution;
2) Adding part of the composition with the effects of controlling oil, removing acnes and removing acne marks and a humectant into the mixed solution obtained in the step 1), heating to 80 ℃, and stirring and dissolving completely;
3) Adding the rest of the composition with the effects of controlling oil, removing acnes and removing acne marks and the daily essence in the step 2), and stirring and dissolving the composition completely to obtain the essence with the effects of controlling oil, removing acnes and removing acne marks.
Compared with the prior art, the invention has the following beneficial effects:
1. the mechanism of acne formation is: a, follicular hyperkeratosis; acne bacteria cause inflammation; c excessive sebaceous gland secretion. The invention selects functional components with the effects of controlling oil, removing acne and removing acne marks from the azelaic diamide-MEA, the madecassoside, the yeast/zinc fermentation product and the polyquaternium-73, and the functional components have a synergistic effect, wherein the azelaic diamide-MEA can inhibit the hyperkeratosis of hair follicles, soften and decompose the hair follicles, gently remove keratinocytes and actively regenerate the cells; the polyquaternium-73 can inhibit acne bacteria, has a strong antibacterial effect, can better improve acne and inflammatory acne caused by microorganisms, quickly control oil and inhibit bacteria, and prevent skin damage; the yeast/zinc fermentation product can inhibit excessive secretion of sebaceous glands, and has the effects of diminishing inflammation, removing acne, controlling oil, reducing dandruff and the like on various beneficial skins by utilizing the enriching capacity of the saccharomyces cerevisiae to zinc in the growth and metabolism process; the madecassoside can inhibit inflammation caused by acne bacteria, lighten acne marks, relieve, repair and resist inflammation, promote collagen synthesis, promote wound healing, block inflammation induced by ultraviolet rays, inhibit expression induced by UVB, inhibit acne formation under the combined action of the four effective components, and achieve the effects of controlling oil, removing acnes and removing acne marks.
2. The oil-controlling acne-removing and acne mark-removing functional components are matched according to a specific proportion, and a plurality of functional components are mutually blended and synergistic, so that skin pores can be opened, the water-oil balance of the skin can be adjusted, acne can be removed, acne marks can be reduced, the damaged skin can be repaired, the skin barrier function can be maintained, and the acne crisis can be solved in multiple directions.
Detailed Description
The invention discloses an essence composition with the effects of controlling oil, removing acnes and removing acne marks and a preparation method thereof, wherein the main components of the essence composition for controlling oil, removing acnes and removing acne marks comprise: madecassoside, yeast/zinc fermentation product, polyquaternium-73, and azelaic acid amide-MEA. The components are matched according to a specific proportion, and various functional components are mutually blended and act synergistically, so that skin pores can be opened, the water-oil balance of skin can be adjusted, acne can be removed, acne marks can be reduced, damaged skin can be repaired, the skin barrier function can be maintained, and the acne crisis can be solved in multiple directions.
Azelaic diamide-MEA, helps to keep the balance of oil secretion in oily skin, seborrheic skin, and melasma-prone skin, is effective against Propionibacterium acnes, corynebacterium, and Staphylococcus epidermidis, and has exfoliating (exfoliating) effect. It has effects of softening and decomposing cutin, mildly removing keratinocyte, and promoting cell regeneration.
Polyquaternium-73, the main function of which is an acne and acne inhibitor with antibacterial activity; the bactericidal composition has a relatively strong killing effect on bacteria and fungi at a relatively low concentration, particularly has a relatively strong antibacterial effect on propionibacterium acnes which can cause acne, can better improve acne and inflammatory acne caused by microorganisms, quickly control oil and inhibit bacteria, and prevent skin lesions from being generated.
The yeast/zinc fermentation product, the yeast essence Z20 (namely the zinc-rich yeast extract Z20 produced by Angel) used in the embodiments and the comparative examples of the invention is extracted and refined by taking a zinc-rich yeast fermentation patent as a technical support, utilizing the zinc enrichment capacity of the saccharomyces cerevisiae in the growth and metabolism process and adopting a modern biological enzymolysis technology. Z20 has the effects of yeast extract, and has the effects of diminishing inflammation, removing acne, controlling oil, reducing dandruff and the like, and is beneficial to skin.
The madecassoside has the main functions of relieving, repairing and resisting inflammation, promoting collagen synthesis, promoting wound healing, blocking ultraviolet induced inflammation, and inhibiting UVB induced expression, so that melanin synthesis and melanosome transfer are inhibited, the level of inflammatory cell factors is obviously reduced, and nerve cells are protected from being damaged by inflammation and autophagy induction.
The oil-control acne-removing and acne-mark-removing lotion creatively combines the four functional components, can resist acne from all aspects, can eliminate acne, can repair skin damage caused by acne, can prevent acne, and can solve the acne crisis of skin in multiple directions and multiple angles.
The present invention is illustrated below by way of a few specific examples, which are provided only for the purpose of further illustration and are not intended to limit the scope of the present invention. Other insubstantial modifications and adaptations of the present invention can be made without departing from the scope of the present invention. Unless otherwise specified, the following percentages (%) are mass percentages.
Examples 1 to 3
A cosmetic composition with effects of controlling oil, removing acne and removing acne marks is prepared into essence, and the content of the raw material components is shown in the following table 1.
TABLE 1 raw material component ratios (% by mass) of examples 1 to 3
The preparation process of the essence with the effects of controlling oil, removing acnes and removing acne marks in the embodiments 1 to 3 comprises the following steps:
1) Wetting and dispersing the thickening agent in the phase A in water completely to obtain a mixed solution;
2) Adding other moisturizing agents, skin conditioning agents and preservatives of the phase A into the mixed solution obtained in the step 1), heating to 80 ℃, and stirring to dissolve the moisturizing agents, the skin conditioning agents and the preservatives completely; adding the functional component nonane diamide-MEA, and stirring to dissolve completely; cooling to 45 ℃;
3) Respectively mixing the raw materials of the phase B, the phase C and the phase D, adding the mixture obtained in the step 2), and stirring and dissolving the mixture completely to obtain the essence with the effects of controlling oil, removing acnes and removing acne marks.
The preparation process of the essence of the blank example comprises the following steps:
1) Wetting and dispersing the thickening agent in the phase A in water completely to obtain a mixed solution;
2) Adding other moisturizing agents, skin conditioners and preservatives of the phase A into the mixed solution in the step 1), heating to 80 ℃, and stirring to dissolve the moisturizing agents, the skin conditioners and the preservatives completely; cooling to 45 ℃;
3) Respectively mixing the raw materials of the phase B, the phase C and the phase D, adding the mixture obtained in the step 2), and stirring and dissolving the mixture completely to obtain the essence with the effects of controlling oil, removing acnes and removing acne marks.
Comparative examples 1 to 8
The essence is prepared from the following raw materials in parts by weight in tables 2-3:
TABLE 2 ingredient ratio table (unit: mass%) of essence for controlling oil, removing acne and removing acne mark in comparative examples 1-4
TABLE 3 ingredient ratio table (unit: mass%) of essence for controlling oil, removing acne and removing acne mark in comparative examples 5-8
The preparation process of the essence of the comparative examples 1 to 8 comprises the following steps:
1) Wetting and dispersing the thickening agent in the phase A in water completely to obtain a mixed solution;
2) Adding other moisturizing agents, skin conditioners and preservatives of the phase A into the mixed solution in the step 1), heating to 80 ℃, and stirring to dissolve the moisturizing agents, the skin conditioners and the preservatives completely; optionally adding a functional component of nonanamide-MEA (if the formulas in the tables 2 and 3 relate to the functional component, or not adding the functional component), and stirring to dissolve completely; cooling to 45 ℃;
3) Mixing the raw materials of the phase B, the phase C and the phase D respectively, and then adding the mixture obtained in the step 2) into the mixture to be stirred and dissolved completely to obtain the essence with the effects of controlling oil, removing acnes and removing acne marks.
Test example for Effect verification
1. Safety test
Test samples: examples 1-3 and comparative examples 1-8 and blanks;
test objects: 120 subjects in the age range of 20-35 years were selected and randomized into 12 groups of 10 subjects each.
The test method comprises the following steps: and testing the safety by adopting a third-party detection mechanism. The selection area is not more than 50mm 2 In a closed patch test, about 0.02-0.025ml (g) of test sample (the serum prepared in examples 1-3 and controls 1-8, respectively, and blank) was applied to a patch tester having a depth of about 1 mm. The patch tester is attached to the curved side of the forearm of a subject (120 persons), the subject is removed after 24h, the skin reaction is observed at 0.5h,24h and 48h after removal, and the result is recorded according to the skin reaction grading standard in the technical and safety regulations for cosmetics 2015.
Remarking: grading standards of skin reaction;
level 0: negative reaction;
stage 1: carrying out suspicious reaction; only faint erythema;
and 2, stage: weak positive reaction (erythema reaction); erythema, infiltration, edema, and possibly papules;
and 3, stage: strong positive reaction (herpes reaction); erythema, infiltration, edema, pimples, herpes; the reaction may be beyond the test area;
and 4, stage 4: very strong response (fusional herpes response); erythema, severe infiltration, edema, fusional herpes, and response beyond the test area.
TABLE 4
The results in table 4 show that the evaluation grades of the essences prepared in the examples, the comparative examples and the blank examples are 0 at 0.5h,24h and 48h, no adverse skin reaction occurs, and the composition and the essence product related to the invention are safe and non-irritant to skin.
2. Stability test
Test samples: examples 1 to 3;
the test method comprises the following steps: and (4) internal control standard: i.e. the appearance color, pH, was observed for three months.
TABLE 5 stability test results (where W denotes week, M denotes month, and cycle denotes temperature cycling once a day from 50 deg.C to-15 deg.C)
The color, viscosity and pH of the essence prepared by the embodiment have no significant change within three months under high and low temperature or illumination, which shows that the essence has better stability.
3. Oil control efficacy test experiment
Testing the content of skin oil:
testing an instrument: sebumeter SM815, manufactured by CK corporation, germany.
And (3) testing conditions are as follows: constant temperature and humidity environment with temperature 23 + -1 deg.C and humidity 50% + -5%, and the subject sits still in the environment for at least 30 minutes before testing.
Subjects with oily skin were recruited 120, 60 men, 60 women. The groups were randomized into 12 groups of 10 people each.
The skin oil content (μ g/cm) on both sides of the nose of the subject was measured with an oil tester Sebumeter SM815 2 ) Recorded as T0 (average of 10 people per group). After each subject washed his/her face, the essence solutions obtained in examples 1, 2 and 3 and the control and blank examples were applied to his/her face, particularly to the sides of his/her nose, once a day in the morning and evening, for 4 weeks. The skin oil content on both sides of the nose of the subject was measured with an oil tester every week, the oil content values of T1 (1 week), T2 (2 weeks later), T3 (3 weeks later) and T4 (4 weeks later) were recorded, the average value of 10 persons per group was calculated, the oil content change rate was further calculated, and the results are shown in table 6.
Oil content change rate = (average of oil content of 10 persons per group after using test sample-average of oil content of 10 persons per group before using test sample, i.e. T0)/average of oil content of 10 persons per group before using test sample, i.e. T0.
The results are shown in Table 6 below.
TABLE 6 test results
As can be seen from table 6, the essence compositions containing the effects of controlling oil, removing acne and removing acne marks obtained in examples 1-3 of the invention can effectively inhibit the secretion of the grease, while the essence compositions obtained in the comparative example have a certain effect of inhibiting the secretion of the grease when one or two of the effect components of the invention are added, but the effect is far inferior to that of examples 1-3, which proves that the combination of the effect components of the invention produces a synergistic effect, while the essence compositions obtained in the blank examples hardly have the effect of inhibiting the secretion of the grease. The essence with the effects of controlling oil, removing acnes and removing acne marks has the effect of controlling oil.
4. Facial image acquisition and acne analysis test
The effects of example 2 and comparative examples 1-8 of the oil-controlling, acne-removing and acne-mark-removing component synergistic experiments were verified, and the experimental steps and results were as follows:
1) The tester: 90 healthy women (20-45 years old) divided into 9 groups of 10 persons each; each group used the same formulation.
2) Test area: the entire face.
3) The following components are used: twice a day, in the morning and at night. The appropriate amount of test sample was applied to the entire face, using the sunscreen product to apply the entire face every morning.
The results were tested at the following 4 time periods, respectively: before use of the sample (D0), after use of the sample for 14 days (D14), after use of the sample for 28 days (D28), and after use of the sample for 56 days (D56). And the average of 10 persons per group was calculated.
4) Testing an instrument: the German CK model is adopted: a rapid three-dimensional imaging system for skin PRIMOS pico.
5) The effect indexes are as follows: primos was used for facial image acquisition and acne analysis.
6)。
Number of volume changes in skin acne (%) = (volume average of 10 human skin acne per group after test sample application-volume average of 10 human skin acne per group before test sample application, i.e., D0)/volume average of 10 human skin acne per group before test sample application, i.e., D0
The results of the number of volume changes of skin acne are shown in table 7.
TABLE 7 test group Effect
The results in table 7 show that the abilities of decreasing acne by simultaneously adding madecassoside, yeast essence Z20, polyquaternium-73, and azelamide-MEA to the essence at 14 days, 28 days, and 56 days are 42.56%, 54.27%, and 68.75%, respectively, and the anti-acne abilities are significantly greater than those of comparative examples 1-8, which indicates that the anti-acne abilities of the four components when used simultaneously are significantly improved compared with those of a certain component and a single component, and it can be seen that the four components have a synergistic function in removing acne. The synergistic function is realized because the four components adopted by the Chinese medicinal composition have different division and cooperation in the aspects of acne removal and inflammation resistance, and can solve the problems of skin acne from eliminating the acne to repairing skin damage caused by the acne to preventing the acne from occurring in multiple directions and multiple angles.
5. Human body trial evaluation experiment
And respectively carrying out crowd trial investigation on the test products. 100 acne skin test subjects aged 19 to 28 years are selected, the essence with the effects of controlling oil, removing acnes and removing acne marks is used for 1 time each day (example 2, comparative examples 1 to 8 and blank examples) for 14 days, a using effect questionnaire is filled, and the statistical results are shown in the following table 8 according to the following conditions.
And (3) healing: the skin lesion is removed, or only a few acne marks and scars are left, and the curative effect index is more than 90 percent;
the effect is shown: the skin lesion is mostly removed, and the curative effect index is 60-90%;
the method has the following advantages: the skin damage is partially removed, and the curative effect index is 20-60%;
and (4) invalidation: the skin damage is not obviously relieved, and the curative effect index is less than 20%.
TABLE 8 group trial survey statistics
From the above experimental data, the following experimental results were obtained:
as can be seen from table 8, the results of the population trial survey show that the subjects had different degrees of regression of the acne lesions after using the essence with the oil-controlling, acne-removing and acne-mark-removing effects of example 2 for 14 days. The blank case and the control case were used, and the acne lesions were less faded after 14 days than the examples.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (10)
1. The composition with the effects of controlling oil, removing acnes and removing acne marks is characterized by comprising the following components in percentage by mass: (1-10): (0.1-1): (1-10): (0.001-0.005) nonanediamide-MEA, madecassoside, yeast/zinc fermentation product and polyquaternium-73.
2. The composition with the effects of controlling oil, removing acnes and removing acne marks according to claim 1, wherein the mass ratio of the azelaic diamide to the MEA, the madecassoside, the yeast/zinc fermentation product to the polyquaternium-73 is (2-8): (0.1-0.6): (1-6): (0.003-0.005).
3. The composition with effects of controlling oil, removing acne and removing acne marks according to claim 1 or 2, wherein the yeast/zinc fermentation product is yeast essence Z20.
4. Essence containing the composition with the effects of controlling oil, removing acnes and removing acne marks according to claim 1, characterized by comprising the following components in percentage by weight:
5-30% of composition with the effects of controlling oil, removing acnes and removing acne marks;
70-95% of cosmetic auxiliary material matrix;
the cosmetic auxiliary material matrix comprises a humectant, a thickening agent, a preservative, a daily essence and deionized water.
5. The essence of claim 4, wherein the combination with the effects of controlling oil, removing acne and removing acne marks comprises 1-10% of azelaic diamide-MEA (amine nonane) based on 100% of the total mass of raw materials for preparing the essence; 0.1-1% of madecassoside; 1-10% yeast/zinc fermentation product; 0.001-0.005% of polyquaternium-73.
6. The essence of claim 4, wherein the cosmetic auxiliary material matrix comprises, based on 100% of the total mass of raw materials for preparing the essence: 0.2-35% of humectant; 0.2-1% of a thickening agent; 0.5-1% of preservative; 0.005-1% of essence for daily use; the balance being deionized water.
7. The essence of claim 4, wherein the essence comprises:
5-20% of composition with the effects of controlling oil, removing acnes and removing acne marks;
80-95% of cosmetic auxiliary material matrix;
the composition with the effects of controlling oil, removing acnes and removing acne marks comprises the following components: 2-8% nonanodiamide-MEA; 0.1-0.6% madecassoside; 1-6% yeast/zinc fermentation product; 0.003-0.005% of polyquaternium-73;
the cosmetic auxiliary material matrix comprises: 0.2-35% of humectant; 0.2-0.8% of a thickening agent; 0.5-1% of preservative; 0.005-1% of daily essence; the balance being deionized water.
8. The essence of claim 4, wherein the moisturizer is selected from the group consisting of one or more of sodium hyaluronate, butylene glycol, hexylene glycol, pentylene glycol, glycerin, and dipropylene glycol.
9. The essence of claim 4, wherein the thickener is selected from one or more of carbomer, xanthan gum, acrylic acid/C10-30 alkanol acrylate crosspolymer, gum arabic, polymer EMT-10, sodium acrylate/sodium acryloyldimethyl taurate, acrylic acid/C10-30 alkanol acrylate crosspolymer copolymer, hydroxyethyl cellulose, agarose; .
The preservative is selected from one or more of phenoxyethanol, ethylhexyl glycerol, jasmone, sodium benzoate, pentanediol and hexanediol.
10. The essence of claim 4, which is prepared by the method comprising the following steps:
1) Wetting and completely dispersing the thickening agent in water to obtain a mixed solution;
2) Adding part of the composition with the effects of controlling oil, removing acnes and removing acne marks and a humectant into the mixed solution obtained in the step 1), and heating to 80 ℃ to completely stir and dissolve the composition;
3) Adding the rest of the composition with the effects of controlling oil, removing acnes and removing acne marks and the daily essence in the step 2), and stirring and dissolving the composition completely to obtain the essence with the effects of controlling oil, removing acnes and removing acne marks.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310058302.3A CN115944551B (en) | 2023-01-19 | 2023-01-19 | Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310058302.3A CN115944551B (en) | 2023-01-19 | 2023-01-19 | Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115944551A true CN115944551A (en) | 2023-04-11 |
| CN115944551B CN115944551B (en) | 2024-07-05 |
Family
ID=87296872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310058302.3A Active CN115944551B (en) | 2023-01-19 | 2023-01-19 | Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115944551B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117530902A (en) * | 2023-12-08 | 2024-02-09 | 广东丸美生物技术股份有限公司 | Acne-removing and inflammation-diminishing composition containing sulfated schizophyllan and application of composition |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010105052A1 (en) * | 2009-03-11 | 2010-09-16 | Isp Investments Inc. | Topical personal care and pharmaceutical compositions and uses thereof |
| WO2018175836A1 (en) * | 2017-03-23 | 2018-09-27 | Isp Investments Llc | Skin care compositions comprising a terpolymer, process for preparing the same and method of use thereof |
| CN111388369A (en) * | 2020-03-31 | 2020-07-10 | 海口楠脂香业有限公司 | Agilawood skin moisturizing lotion and preparation method thereof |
| CN111419755A (en) * | 2020-04-30 | 2020-07-17 | 海口楠脂香业有限公司 | Agilawood fullerene essence and preparation method thereof |
| CN112545954A (en) * | 2020-12-16 | 2021-03-26 | 广州市拉凯尔干细胞研究所 | Balance smoothing toner for improving skin conditions |
| CN113712873A (en) * | 2021-09-26 | 2021-11-30 | 湖北省麦诗特生物科技有限公司 | Essence emulsion composition with acne-removing and anti-inflammatory effects and preparation method thereof |
| CN114588060A (en) * | 2022-04-27 | 2022-06-07 | 江门市耀扬科技有限公司 | Whitening and moisturizing mask with acne removing effect and preparation method thereof |
| CN114712283A (en) * | 2022-04-12 | 2022-07-08 | 北京至乐界生物科技有限公司 | Oil-control acne-clearing composition and application thereof in skin care products |
| CN115192484A (en) * | 2022-08-05 | 2022-10-18 | 广州优然生物科技有限公司 | Essence with oil control and acne removal effects and preparation method thereof |
| CN115414308A (en) * | 2022-10-09 | 2022-12-02 | 广州阿基米德生物科技有限公司 | Acne removing composition as well as preparation method and application thereof |
-
2023
- 2023-01-19 CN CN202310058302.3A patent/CN115944551B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010105052A1 (en) * | 2009-03-11 | 2010-09-16 | Isp Investments Inc. | Topical personal care and pharmaceutical compositions and uses thereof |
| WO2018175836A1 (en) * | 2017-03-23 | 2018-09-27 | Isp Investments Llc | Skin care compositions comprising a terpolymer, process for preparing the same and method of use thereof |
| CN111388369A (en) * | 2020-03-31 | 2020-07-10 | 海口楠脂香业有限公司 | Agilawood skin moisturizing lotion and preparation method thereof |
| CN111419755A (en) * | 2020-04-30 | 2020-07-17 | 海口楠脂香业有限公司 | Agilawood fullerene essence and preparation method thereof |
| CN112545954A (en) * | 2020-12-16 | 2021-03-26 | 广州市拉凯尔干细胞研究所 | Balance smoothing toner for improving skin conditions |
| CN113712873A (en) * | 2021-09-26 | 2021-11-30 | 湖北省麦诗特生物科技有限公司 | Essence emulsion composition with acne-removing and anti-inflammatory effects and preparation method thereof |
| CN114712283A (en) * | 2022-04-12 | 2022-07-08 | 北京至乐界生物科技有限公司 | Oil-control acne-clearing composition and application thereof in skin care products |
| CN114588060A (en) * | 2022-04-27 | 2022-06-07 | 江门市耀扬科技有限公司 | Whitening and moisturizing mask with acne removing effect and preparation method thereof |
| CN115192484A (en) * | 2022-08-05 | 2022-10-18 | 广州优然生物科技有限公司 | Essence with oil control and acne removal effects and preparation method thereof |
| CN115414308A (en) * | 2022-10-09 | 2022-12-02 | 广州阿基米德生物科技有限公司 | Acne removing composition as well as preparation method and application thereof |
Non-Patent Citations (5)
| Title |
|---|
| MOHAMMAD ALI REZVANI;SAHAR KHANDAN;NEGIN SABAHI;HAMID SAEIDIAN;: "Deep oxidative desulfurization of gas oil based on sandwich-type polysilicotungstate supported β-cyclodextrin composite as an efficient heterogeneous catalyst", CHINESE JOURNAL OF CHEMICAL ENGINEERING, no. 10, 15 October 2019 (2019-10-15) * |
| 张剑, 姜振玉, 陈建定: "聚酯酰胺热塑性弹性体的合成与性能", 中国塑料, no. 05, 26 May 2004 (2004-05-26) * |
| 张怡;徐勇威;龚盛昭;: "一种草本复方祛痘化妆品的功效研究", 香料香精化妆品, no. 04, 31 August 2018 (2018-08-31) * |
| 李小迪;: "协同增效抗痘系列化妆品配方开发", 香料香精化妆品, no. 03, 30 June 2007 (2007-06-30) * |
| 赵毕明 , 李根远 , 唐维高 , 宋煦然: "脂肪系高级二元酰胺的Hofmann反应", 四川大学学报(自然科学版), no. 01, 28 February 1960 (1960-02-28) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117530902A (en) * | 2023-12-08 | 2024-02-09 | 广东丸美生物技术股份有限公司 | Acne-removing and inflammation-diminishing composition containing sulfated schizophyllan and application of composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115944551B (en) | 2024-07-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60213449T2 (en) | COMPOSITIONS CONTAINING AN ETHANOLAMINE DERIVATIVE AND ORGANIC METAL SALTS | |
| CN108969429B (en) | Acne removing essence | |
| CN110693807B (en) | Skin bottom essence and preparation method thereof | |
| CN113304075B (en) | Glacier rock cleaning oil control mud film and preparation method thereof | |
| CN113712873B (en) | Essence emulsion composition with acne removing and anti-inflammatory effects and preparation method thereof | |
| CN113693962A (en) | Fibronectin-containing multiple protein repair composition and preparation method thereof | |
| CN111939116A (en) | Anti-aging composition and preparation method thereof | |
| WO2024045952A1 (en) | Recombinant collagen-containing composition having effects of repairing and soothing, eye cream containing same, preparation method therefor, and use thereof | |
| CN109394645A (en) | A kind of painting type water laser accunputure essence and preparation method thereof | |
| CN115944551B (en) | Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence | |
| CN115317427A (en) | Anti-inflammatory repairing composition and preparation method and application thereof | |
| CN112516066B (en) | Oil control composition and application thereof in cosmetics | |
| CN116509774B (en) | Anti-dandruff shampoo preparation containing sweet wormwood herb extract and preparation method thereof | |
| CN116421514A (en) | Acne-removing composition and eye cream for non-irritation of eyes, and preparation method and application of acne-removing composition and eye cream | |
| CN113712871B (en) | Essence emulsion composition containing liposome with comedones removing effect and preparation method thereof | |
| CN110711166A (en) | Toner with oil control and moisture retention effects | |
| CN110025508A (en) | A kind of essence cream and preparation method thereof preventing striae of pregnancy generation | |
| CN116115528A (en) | Composition for relieving, repairing and moisturizing as well as application and preparation method thereof | |
| CN115919686A (en) | Skin soothing lotion for enhancing skin barrier and preparation method thereof | |
| CN113576994A (en) | Composition with synergistic moisturizing and relieving effects, cosmetic and preparation method thereof | |
| CN112402309A (en) | Multi-vitamin mineral essence cream and preparation method thereof | |
| CN113384483A (en) | Composition for improving skin elasticity and delaying aging and preparation method thereof | |
| CN114712277B (en) | Moisturizing and repairing composition, cosmetic and preparation method | |
| CN114796013B (en) | Oil control composition and application thereof in cosmetics | |
| CN116139060B (en) | Composition with anti-inflammatory and anti-aging effects and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant |