CN108969429B - Acne removing essence - Google Patents
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Abstract
The invention discloses acne-removing essence which comprises an acne-removing composition A; the acne-removing composition A comprises salvia miltiorrhiza root extract, clove bud extract, scutellaria baicalensis root extract, angelica root extract, liquorice root extract and centella asiatica extract. According to the acne removing essence disclosed by the invention, mild plant extract components are added and matched with basic raw materials to prepare the acne removing essence, so that the acne removing essence can be used for adjusting the water-oil balance of skin, removing acnes, fading acne marks, repairing damaged skin and recovering the natural health state of the skin.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to acne-removing essence.
Background
With the development of economy and the continuous improvement of life quality, the acne removing consciousness of Chinese acne patients is improved year by year. The combined survey results of the Chinese dermatosis society and the Chinese teenager union show that the incidence of acne in China is on a rising trend year by year, more than 80% of young people suffer from the problem of acne in different degrees, and the serious disease condition of the young people is more than 1/3.
Acne is commonly known as acne, also called as "whelk", "pimple" or "comedo", and is a skin disease caused by the blockage and inflammation of hair follicles and sebaceous glands. At puberty, the hormone in the body stimulates hair growth and promotes sebaceous gland to secrete more oil, and the hair and sebaceous gland accumulate a lot of substances, which is called as acne because the symptom is common to young men and women.
Acne is a common chronic skin disease, the number of teenagers is the highest, the acne is frequently found on the face, chest and back, and various skin injuries such as blackheads, papules, pustules, nodules, cysts, scars and the like are shown, so that the acne hinders the appearance. The main cause of the whelk is acne caused by the accumulation of sebum due to the blockage of pores caused by the accumulation of sebum, which once infected will deteriorate in a short time to form severe cysts or abscesses.
Acne itself is not afraid, and the biggest harm is that acne marks, acne pits and acne scars are easy to remain in time or irregular treatment, and the image is seriously influenced. Pockmarks are actually inflammatory attacks that, in addition to manual squeezing, damage the epidermis, dermis and underlying subcutaneous tissues of the skin, resulting in skin destruction, tissue defects and scar formation. These problems not only seriously affect the appearance, but also have certain difficulties in treatment.
Therefore, for the acne-removing population, in order to completely remove acne marks, a safe and effective acne-removing product is essential except for paying attention to daily diet and living habits.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide the acne-removing essence.
In order to achieve the purpose, the invention adopts the technical scheme that: an acne-removing essence comprises an acne-removing composition A; the acne-removing composition A comprises salvia miltiorrhiza root extract, clove bud extract, scutellaria baicalensis root extract, angelica root extract, liquorice root extract and centella asiatica extract.
According to the acne-removing composition A, the salvia miltiorrhiza root extract has the effects of inhibiting bacteria, controlling oil and diminishing inflammation, the angelica root extract has the effects of promoting blood circulation to remove blood stasis and improving follicular keratosis, the licorice root extract and the centella asiatica extract have the effects of harmonizing and repairing, and the clove bud extract and the scutellaria baicalensis root extract can promote the transdermal absorption of the salvia miltiorrhiza root extract, the angelica root extract, the licorice root extract, the centella asiatica extract and the like and dredge pores, so that safe and effective acne removal is realized. The acne-removing composition A has the following characteristics: 1) inhibiting 5 alpha-reductase activity, balancing sebum secretion; 2) inhibiting the growth of acne-related pathogenic flora in the follicular sebum, inhibiting bacteria and diminishing inflammation; 3) good acne inhibiting activity, and can improve skin acne caused by cosmetics; 4) the acne removing effect is synergistically improved through three ways of promoting penetration and absorption, dredging pores and improving follicular keratosis.
Preferably, the acne-removing composition A comprises the following components in parts by weight: 10-20 parts of salvia miltiorrhiza root extract, 2-4 parts of clove bud extract, 1-3 parts of scutellaria baicalensis root extract, 1-3 parts of angelica sinensis root extract, 0.5-2 parts of licorice root extract and 0.5-2 parts of centella asiatica extract.
More preferably, the acne-removing composition a comprises the following components in parts by weight: 15 parts of salvia miltiorrhiza root extract, 3 parts of clove bud extract, 2 parts of scutellaria baicalensis root extract, 2 parts of angelica root extract, 1 part of liquorice root extract and 1 part of centella extract. When the extracts are mixed according to the proportion, the extracts can fully exert respective functions.
Preferably, the acne-removing composition A accounts for 0.4-0.6 wt% of the acne-removing essence. The acne-removing composition A can achieve the acne-removing effect by adopting the addition amount in the essence, so that the aim of efficient utilization is fulfilled.
Preferably, the essence further comprises an acne-removing composition B; the acne-removing composition B comprises oldenlandia diffusa extract, honeysuckle extract and Chinese honey locust seed extract.
The oldenlandia diffusa extract has anti-inflammatory and antibacterial effects, and has different degrees of antibacterial and bactericidal effects on cocci and bacilli; the honeysuckle stem has the functions of antibiosis and antiphlogosis, and has obvious bacteriostatic activity on staphylococcus aureus and propionibacterium acnes. The acne-removing composition B has a remarkable inhibiting effect on 5 alpha-reductase by matching of the extracts, can relieve acne symptoms, can reduce acne marks, and has an oil control effect. The acne-removing composition B and the acne-removing composition A are matched together, so that acne can be effectively relieved, cells can be helped to regenerate, damaged cell tissues can be repaired, fibrous tissue reconstruction is activated, the skin is smooth and fine, roughness is smoothed, moisture and nutrition are supplemented, the skin is soft, moist and elastic, and acne-removing is realized.
Preferably, the acne-removing composition B comprises the following components in parts by weight: 2-4 parts of oldenlandia diffusa extract, 2-4 parts of honeysuckle extract and 0.5-2 parts of Chinese honey locust seed extract. When the extracts are mixed according to the proportion, the extracts can fully exert respective functions.
More preferably, the acne-removing composition B comprises the following components in parts by weight: 3 parts of oldenlandia diffusa extract, 3 parts of honeysuckle extract and 1 part of Chinese honey locust seed extract.
Preferably, the acne-removing composition B accounts for 0.4-0.6% of the acne-removing essence by weight. The acne removing composition B can achieve the effect of removing acne marks by adopting the addition amount in the essence, and the efficient utilization of the composition B is realized.
Preferably, the essence further comprises 2-3% of guava fruit extract and 0.02-0.03% of phellodendron amurense extract. The guava fruit extract and the phellodendron amurense extract have the anti-inflammatory and antibacterial effects, and the anti-acne composition A and the anti-acne composition B are matched with the above additive amount to exert the effects.
Preferably, the essence further comprises a skin-activating component; the skin-activating component comprises niacinamide, menthol, camphor and borneol; the skin-activating component comprises the following components in percentage by weight in the essence: 1.5-2.4% of nicotinamide, 0.016-0.025% of menthol, 0.008-0.013% of camphor and 0.007-0.012% of borneol.
The skin-activating component can activate skin, infiltrate stratum corneum, promote skin absorption of plant extracts such as acne-removing composition A, acne-removing composition B, guava fruit extract and cortex Phellodendri extract, improve hair follicle keratinization, and inhibit bacteria, diminish inflammation and control oil more effectively.
Preferably, the essence further comprises a humectant, an emulsifier and a thickener; the humectant comprises propylene glycol and glycerin; the emulsifier is PEG-40 hydrogenated castor oil; the thickener comprises carbomer and hydroxyethyl cellulose.
Preferably, the essence comprises the following components in percentage by weight: 0.4-0.6% of acne-removing composition A, 0.4-0.6% of acne-removing composition B, 2-3% of guava fruit extract, 0.02-0.03% of phellodendron amurense extract, 1.5-2.4% of nicotinamide, 0.016-0.025% of menthol, 0.008-0.013% of camphor, 0.007-0.012% of borneol, 1.8-2.8% of propylene glycol, 0.8-1.2% of glycerol, 0.4-0.5% of PEG-40 hydrogenated castor oil, 0.15-0.25% of carbomer, 0.04-0.06% of hydroxyethyl cellulose and 0.04-0.06% of disodium EDTA. The essence prepared according to the proportion has the effects of regulating the water-oil balance of skin, diminishing inflammation and fading acne marks.
More preferably, the essence comprises the following components in percentage by weight: 0.5% of acne-removing composition A, 0.5% of acne-removing composition B, 2.5% of guava fruit extract, 0.025% of phellodendron amurense extract, 2% of nicotinamide, 0.02% of menthol, 0.01% of camphor, 0.01% of borneol, 2.21% of propylene glycol, 1% of glycerol, 0.45% of PEG-40 hydrogenated castor oil, 0.2% of carbomer, 0.05% of hydroxyethyl cellulose and 0.05% of disodium EDTA. The essence adopting the formula has the best acne removing effect.
Preferably, the essence further comprises a preservative; the preservative is a mixture of methyl hydroxybenzoate, bis (hydroxymethyl) imidazolidinyl urea and iodopropynyl alcohol butyl carbamate.
In addition to the above components, the essence of the present invention may be added or used with other auxiliary components, such as pH regulator, essence, pigment, etc., within the range of not impairing the effects of the present invention, and those skilled in the art may select the content to be used conventionally according to conventional standards.
The invention has the beneficial effects that: the invention provides acne-removing essence which is prepared by adding mild plant extract components and matching with basic raw materials, and can be used for regulating water-oil balance of skin, removing acnes, fading acne marks, repairing damaged skin and recovering natural health state of skin.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1 to 10
The embodiments 1 to 10 are embodiments of the acne-removing essence disclosed by the invention, and the formulas of the acne-removing essence disclosed by the embodiments 1 to 6 are shown in table 1. The formula of the acne-removing essence described in examples 7-10 is shown in table 2. In embodiments 1 to 10, the acne-removing composition a comprises the following components in parts by weight: 15 parts of salvia miltiorrhiza root extract, 3 parts of clove bud extract, 2 parts of scutellaria baicalensis root extract, 2 parts of angelica root extract, 1 part of liquorice root extract and 1 part of centella extract; the acne-removing composition B comprises the following components in parts by weight: 3 parts of oldenlandia diffusa extract, 3 parts of honeysuckle extract and 1 part of Chinese honey locust seed extract.
The preparation method of the acne-removing essence comprises the following steps:
s1, homogenizing carbomer and water by using a hanging type homogenizer until the carbomer and the water are uniformly dispersed without particles, uniformly dispersing propylene glycol and hydroxyethyl cellulose, and preheating PEG-40 hydrogenated castor oil, menthol, camphor and borneol until the carbomer and the water are dissolved for later use;
s2, adding carbomer, water, propylene glycol, hydroxyethyl cellulose, water, glycerol, EDTA disodium and methyl hydroxybenzoate into a main pot, stirring and heating to 85 ℃, homogenizing for 3-5 minutes until no particles exist, preserving heat and stirring for 20 minutes, and then cooling;
s3, cooling to 60 ℃, adding PEG-40 hydrogenated castor oil, menthol, camphor, borneol, guava fruit extract and nicotinamide, and stirring uniformly;
s4, cooling to 50 ℃, adding bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate, propylene glycol, and solubilized transparent melaleuca alternifolia leaf oil, PEG-40 hydrogenated castor oil, an acne removing composition A and an acne removing composition B, stirring uniformly, cooling to normal temperature, and discharging after inspection to obtain the acne removing essence.
Table 1 formula of acne removing essence described in examples 1 to 6
Comparative examples 1 and 2
The formulas of the acne-removing essence liquids of comparative examples 1 and 2 are shown in table 2. The acne-removing composition B comprises the following components in parts by weight: 3 parts of oldenlandia diffusa extract, 3 parts of honeysuckle extract and 1 part of Chinese honey locust seed extract. The formula of the acne-removing essence described in examples 7-10 is shown in table 2. The preparation method of the acne-removing essence liquid in comparative examples 1 and 2 is the same as that in examples 1-10.
Table 2 formulas of acne removing essence solutions according to examples 7 to 10 and comparative examples 1 and 2
The products of examples 1-10 and comparative examples 1 and 2 are tested to meet the relevant requirements of QB/T1857-.
Example 11
Product safety evaluation (human body skin patch experiment)
Firstly, testing a test article: acne removing essence prepared in examples 1-10 and comparative examples 1 and 2
Number of test population: 120 people, female
Age: between 12 and 30 years old
Health condition: the skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject.
Grouping: 12 groups of 10 people each, mean age 25 ± 2 years.
Secondly, a spot pasting method: selecting a qualified spot tester, dripping 0.020 g-0.025 g of a tested object into the spot tester in a closed spot patch test mode, externally applying a special adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions after 0.5, 6, 12, 24 and 48 hours after the tested object is removed respectively, and recording the results according to the skin reaction grading standard in the cosmetic hygiene standard.
Thirdly, experimental results: the result of the human body skin patch test shows that: each group of subjects pass through the patch test of the acne-removing essence described in examples 1-10 and comparative examples 1 and 2, and observe skin reactions in 0.5, 6, 12, 24 and 48 hours, wherein 0 case of the subjects has adverse skin reactions, which indicates that the acne-removing essence is safe to use.
Example 12
Test of bacteriostatic Effect
First, test materials
1. Test strains: propionibacterium acnes (ATCC 6919).
2. Test samples: storing samples S1, S2, S3, S4, S5, S6, S7, S8, S9, D1 and D2 at 4 ℃ for later use, wherein the proportions of the anti-acne ingredients in S1, S2, S3, S4, S5, S6, S7, S8, S9, D1 and D2 respectively correspond to the proportions of the anti-acne ingredients in examples 1-9 and comparative examples 1 and 2.
3. Culture medium: the pH of the culture medium for the acne propionibacterium acnes is adjusted to 6.6-7.0. Wherein 15g/L of agar is added into the solid culture medium.
Second, test method
1. Preparing and inoculating a bacterial suspension: taking 0.1mL of the frozen and preserved bacterial suspension to be placed in 5mL of propionibacterium acnes liquid culture medium, and culturing for 2d under the anaerobic condition at 37 ℃ to obtain experimental bacterial suspension.
2. Preparing a liquid medicine: s1, S2, S3, S4, S5, S6, S7, S8, S9, D1, and D2 were diluted with physiological saline to test concentration 0.1%, respectively, and then diluted in a gradient. The gradient dilution concentrations of the first test were 100% (sample stock solution), 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, respectively. The concentration of the second test retest gradient dilution is 10%, 8%, 6%, 4% and 2%, respectively.
3. Preparing bacterial liquid: the bacterial suspension was diluted with Propionibacterium acnes liquid medium to a final bacterial concentration of l06CFU/mL。
4. Culturing and judging results: adding 100 μ L of bacteria solution and 100 μ L of liquid medicine into the micropores, setting negative control without bacteria and normal growth control without liquid medicine, making 3 parallels for each medicine, and taking average value. Anaerobic incubation is carried out at 37 ℃, and the result is observed after 48 hours. Whether turbidity exists or not is judged by naked eyes, and data are read by a direct method. The premise of result judgment is that the growth contrast is good, the blank contrast aseptically grows clearly, and the growth of bacteria in other holes is inhibited along with the increase of the drug concentration gradient.
TABLE 3 results of the first bacteriostatic gradient test
Note: wherein "+" represents the presence of bacteria and "-" represents the absence.
TABLE 4 results of the second bacteriostatic gradient test
Note: wherein "+" represents the presence of bacteria and "-" represents the absence.
5. Results
As can be seen from the results in Table 3, the 0.1% solutions of examples 1-6, 8, and 9, when diluted to a concentration of 12.5% or more, have a good inhibitory effect on Propionibacterium acnes, whereas the 25% dilution of example 7 and above are effective, and the 50% concentration of comparative examples 1 and 2 is required. The results in table 4 show that the bacteriostatic concentration of the solutions in examples 1 to 6 can be achieved by 10% of the diluent, and the bacteriostatic concentration of the solution in example 1 can achieve the bacteriostatic effect by 6% of the diluent. According to the results, the minimal addition of the acne-removing component is about 0.01%, so that the effect of inhibiting propionibacterium acnes can be basically achieved, and the acne-removing component has stronger bacteriostatic effect when being used together by adopting the acne-removing composition A, the acne-removing composition B, the guava fruit extract and the amur corktree extract than when being used by using one or two of the components.
Example 13
Clinical tests are carried out on the essences of examples 1-10 and comparative examples 1 and 2, and the clinical tests are as follows:
the number of people: 120 people, divided into 12 groups, each group has 10 people, the proportion of male to female is 1:1, and acne exists on the face
Time: 21 days
The part: face part
Sample preparation: essence liquid described in examples 1-10 and comparative examples 1 and 2
Evaluation: evaluation and photographing according to the GAGS scoring method were performed (photograph not shown):
the GAGS scoring method is a Global Acid Grading System (GAGS) of an Acne comprehensive Grading System proposed by Doshi et al in 1997, is a scoring method, and has the characteristics of accuracy, strong consistency, quickness, good overall evaluation effect and the like. The method specifically comprises the following steps: according to the density, distribution and approximate area of the pilosebaceous unit, the good hair part of the acne is divided into 6 areas: zone i, forehead, zone ii: right cheek, zone iii: left cheek, region iv: nose, chin zone v, zone vi: chest and upper back. The scores of factors in the I, II and III zones are 2, the scores of factors in the IV and V zones are 1, the score of factors in the VI zone is 3, and the score of the skin loss of each zone is (the principle is that the local most serious skin loss determines the score of the zone): 0 is no skin damage; 1 is more than or equal to 1 acne; 2 or more than 1 pimple; 3, more than or equal to 1 abscess; 4 is more than or equal to 1 node. The total score of each subarea is factor score multiplied by skin damage score, and the sum of the total scores of different subareas is the comprehensive score.
The evaluation results are shown in Table 5.
TABLE 5 GAGS score evaluation results of the essences described in examples 1 to 10 and comparative examples 1 and 2
| Group of | Before use | 3 days | 7 days | 14 days | 21 days |
| Example 1 | 18.2 | 13.3* | 10.2** | 8.0** | 6.6** |
| Example 2 | 18.6 | 15.5* | 12.3** | 10.5** | 8.9** |
| Example 3 | 19.0 | 16.2* | 13.3** | 11.2** | 9.5** |
| Example 4 | 18.8 | 14.3* | 12.2** | 10.3** | 9.3** |
| Example 5 | 18.6 | 15.3* | 12.9** | 10.1** | 8.8** |
| Example 6 | 17.6 | 13.6* | 11.0** | 9.9** | 8.8** |
| Example 7 | 17.5 | 15.7* | 13.7* | 12.0** | 11.3** |
| Example 8 | 18.2 | 16.5* | 14.4* | 13.3** | 12.8** |
| Example 9 | 18.4 | 15.5* | 12.3** | 10.0** | 8.3** |
| Example 10 | 19.0 | 16.5* | 13.6** | 12.0** | 10.6** |
| Comparative example 1 | 18.2 | 16.8 | 15.8* | 14.6** | 13.7** |
| Comparative example 2 | 18.5 | 17.0 | 16.2* | 15.6** | 14.5** |
P < 0.05VS before use, P < 0.01VS before use
As can be seen from Table 3, the serum described in examples 1-10 showed a significant decrease in acne score after 3 days (P < 0.05), a significant decrease at 7, 14 and 21 days, and a statistical significance (P < 0.01) compared to the pre-application period. As can be seen from the table, compared with example 1, examples 4 to 6 have higher comprehensive scores after 21 days of use, which indicates that the acne-removing compositions a and B need to be in a certain proportion to exert better acne-removing effects; compared with the example 1, the acne removing effects of the examples 7-9 and the comparative examples 1 and 2 are poorer, which shows that the acne removing composition A, the acne removing composition B, the guava fruit extract and the phellodendron amurense extract have better effects when being used together, the acne removing effect of the example 10 is poorer than that of the example 1, and shows that the nicotinamide exerts certain auxiliary acne removing effect.
Example 14
Evaluation of product Effect
Firstly, testing a test article: acne removing essence prepared in embodiments 1 to 3
Second, the tested population
Sex number: 90 people with a male to female ratio of about 1:1
Age: between 12 and 30 years old
Health condition: the skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject.
Grouping: divided into 3 groups of 30 persons each, with a mean age of 25 ± 2 years.
Thirdly, a testing method: the acne removal essence prepared in examples 1-3 is used respectively to observe and feel the using effect. The using method comprises the following steps: after the face of a subject is cleaned, a proper amount of acne-removing essence is uniformly smeared on the face and is massaged until the acne-removing essence is absorbed. The medicine is taken once a day, morning and evening, and is used for one month, and is checked at least once a week to know whether systemic and local adverse reactions exist, and the result is recorded in detail.
The test evaluation results are shown in tables 6-8.
Table 6 example 1 summary of trial (one month) feedback of anti-acne essence
Table 7 example 2 summary of trial (one month) feedback of anti-acne essence
Table 8 example 3 summary of trial (one month) feedback of anti-acne essence
From tables 6 to 8, the acne-removing essence disclosed by the embodiments 1 to 3 is widely popular and accepted by the subjects, and the subjects all show that the acne-removing essence disclosed by the invention is mild in texture, can astringe pores, soothe skin, adjust the water and oil balance of the skin, and deeply repair and condition the acne skin. The acne-removing essence of example 1 has the highest acceptance in examples 1 to 3. Meanwhile, no allergy phenomenon occurs in all the subjects, and the conditions of skin itch, stabbing pain, red swelling and the like do not occur. Therefore, the acne-removing essence is warm and safe and can be used for a long time.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (4)
1. An acne-removing essence is characterized by comprising an acne-removing composition A and an acne-removing composition B; the acne-removing composition A comprises the following components in parts by weight: 15 parts of salvia miltiorrhiza root extract, 3 parts of clove bud extract, 2 parts of scutellaria baicalensis root extract, 2 parts of angelica root extract, 1 part of liquorice root extract and 1 part of centella extract; the acne-removing composition A accounts for 0.5 percent of the acne-removing essence by weight; the acne-removing composition B comprises the following components in parts by weight: 3 parts of oldenlandia diffusa extract, 3 parts of honeysuckle extract and 1 part of Chinese honey locust seed extract; the acne-removing composition B accounts for 0.5 percent of the acne-removing essence; the essence also comprises 2.5% of guava fruit extract and 0.025% of phellodendron amurense extract; the essence also comprises a skin-activating component; the skin-activating component comprises niacinamide, menthol, camphor and borneol; the skin-activating component comprises the following components in percentage by weight in the essence: nicotinamide 2%, menthol 0.02%, camphor 0.01% and borneol 0.01%.
2. The acne-removing essence according to claim 1, wherein the essence further comprises a moisturizing agent, an emulsifying agent and a thickening agent; the humectant comprises propylene glycol and glycerin; the emulsifier is PEG-40 hydrogenated castor oil; the thickener comprises carbomer and hydroxyethyl cellulose.
3. The acne-removing essence according to claim 1, wherein the essence comprises the following components in percentage by weight: 0.5% of acne-removing composition A, 0.5% of acne-removing composition B, 2.5% of guava fruit extract, 0.025% of phellodendron amurense extract, 2% of nicotinamide, 0.02% of menthol, 0.01% of camphor, 0.01% of borneol, 1.8-2.8% of propylene glycol, 0.8-1.2% of glycerol, 0.4-0.5% of PEG-40 hydrogenated castor oil, 0.15-0.25% of carbomer, 0.04-0.06% of hydroxyethyl cellulose and 0.04-0.06% of disodium EDTA.
4. The acne-removing essence according to claim 3, wherein the essence comprises the following components in percentage by weight: 0.5% of acne-removing composition A, 0.5% of acne-removing composition B, 2.5% of guava fruit extract, 0.025% of phellodendron amurense extract, 2% of nicotinamide, 0.02% of menthol, 0.01% of camphor, 0.01% of borneol, 2.21% of propylene glycol, 1% of glycerol, 0.45% of PEG-40 hydrogenated castor oil, 0.2% of carbomer, 0.05% of hydroxyethyl cellulose and 0.05% of disodium EDTA.
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| CN109602661A (en) * | 2019-01-23 | 2019-04-12 | 广州葆妍生物科技有限公司 | A kind of blemish clearing gel and preparation method thereof |
| CN109700670A (en) * | 2019-02-28 | 2019-05-03 | 栾兆东 | It is a kind of can active cell, deep water supplement moisturizing, the silk mask of anti-aging and preparation method thereof |
| CN110522687A (en) * | 2019-08-22 | 2019-12-03 | 广州市茗妍化妆品有限公司 | A kind of anti-acne shin moisturizer and preparation method thereof |
| CN110368348A (en) * | 2019-08-29 | 2019-10-25 | 广州重生化妆品实业有限公司 | A kind of formula of acne removal stock liquid and preparation method thereof |
| CN110652486A (en) * | 2019-11-12 | 2020-01-07 | 江苏逸洁生物科技股份有限公司 | Medicinal acne-removing gel |
| CN111743831A (en) * | 2020-06-24 | 2020-10-09 | 广州品赫生物科技有限公司 | Acne removing composition |
| CN113143817B (en) * | 2021-03-23 | 2023-06-20 | 山东益得来生物科技有限公司 | Jerusalem artichoke acne-removing composition and application thereof |
| CN113081933A (en) * | 2021-04-12 | 2021-07-09 | 建昌帮药业有限公司 | Acne-removing composition and preparation method and application thereof |
| CN113208993A (en) * | 2021-05-17 | 2021-08-06 | 威海萨维诺健康管理有限公司 | Skin care essence with multiple effects and preparation method thereof |
| CN115054561A (en) * | 2022-07-22 | 2022-09-16 | 中植(山东)生物技术有限责任公司 | Compound plant extract with acne removing effect and preparation method thereof |
| CN115025024B (en) * | 2022-07-29 | 2023-11-03 | 维怡美生物科技(广州)有限公司 | Acne and mark removing composition and application thereof |
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