CN109157451B - Acne-removing facial cleanser - Google Patents
Acne-removing facial cleanser Download PDFInfo
- Publication number
- CN109157451B CN109157451B CN201811207350.XA CN201811207350A CN109157451B CN 109157451 B CN109157451 B CN 109157451B CN 201811207350 A CN201811207350 A CN 201811207350A CN 109157451 B CN109157451 B CN 109157451B
- Authority
- CN
- China
- Prior art keywords
- acne
- facial cleanser
- extract
- skin
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses acne-removing facial cleanser which comprises an acne-removing composition A; the acne-removing composition A comprises salvia miltiorrhiza root extract, clove bud extract, scutellaria baicalensis root extract, angelica root extract, liquorice root extract and centella asiatica extract. According to the acne-removing facial cleanser, mild plant extract components are added and matched with basic raw materials to prepare the acne-removing facial cleanser, so that the acne-removing facial cleanser can penetrate into the bottom of skin to remove skin stains, deeply control oil, adjust the water-oil balance of the skin, remove acnes, fade acne marks, repair damaged skin and restore the natural health state of the skin.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to acne-removing facial cleanser.
Background
With the development of economy and the continuous improvement of life quality, the acne removing consciousness of Chinese acne patients is improved year by year. The combined survey results of the Chinese dermatosis society and the Chinese teenager union show that the incidence of acne in China is on a rising trend year by year, more than 80% of young people suffer from the problem of acne in different degrees, and the serious disease condition of the young people is more than 1/3.
Acne is commonly known as acne, also called as "whelk", "pimple" or "comedo", and is a skin disease caused by the blockage and inflammation of hair follicles and sebaceous glands. At puberty, the hormone in the body stimulates hair growth and promotes sebaceous gland to secrete more oil, and the hair and sebaceous gland accumulate a lot of substances, which is called as acne because the symptom is common to young men and women.
Acne is a common chronic skin disease, the number of teenagers is the highest, the acne is frequently found on the face, chest and back, and various skin injuries such as blackheads, papules, pustules, nodules, cysts, scars and the like are shown, so that the acne hinders the appearance. The main cause of the whelk is acne caused by the accumulation of sebum due to the blockage of pores caused by the accumulation of sebum, which once infected will deteriorate in a short time to form severe cysts or abscesses.
Acne itself is not afraid, and the biggest harm is that acne marks, acne pits and acne scars are easy to remain in time or irregular treatment, and the image is seriously influenced. Pockmarks are actually inflammatory attacks that, in addition to manual squeezing, damage the epidermis, dermis and underlying subcutaneous tissues of the skin, resulting in skin destruction, tissue defects and scar formation. These problems not only seriously affect the appearance, but also have certain difficulties in treatment.
Therefore, for the acne-removing population, in order to completely remove acne marks, a safe and effective acne-removing product is essential except for paying attention to daily diet and living habits.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide the acne-removing facial cleanser.
In order to achieve the purpose, the invention adopts the technical scheme that: an acne-removing facial cleanser comprises an acne-removing composition A; the acne-removing composition A comprises salvia miltiorrhiza root extract, clove bud extract, scutellaria baicalensis root extract, angelica root extract, liquorice root extract and centella asiatica extract.
According to the acne-removing composition A, the salvia miltiorrhiza root extract has the effects of inhibiting bacteria, controlling oil and diminishing inflammation, the angelica root extract has the effects of promoting blood circulation to remove blood stasis and improving follicular keratosis, the licorice root extract and the centella asiatica extract have the effects of harmonizing and repairing, and the clove bud extract and the scutellaria baicalensis root extract can promote the transdermal absorption of the salvia miltiorrhiza root extract, the angelica root extract, the licorice root extract, the centella asiatica extract and the like and dredge pores, so that safe and effective acne removal is realized. The acne-removing composition A has the following characteristics: 1) inhibiting 5 alpha-reductase activity, balancing sebum secretion; 2) inhibiting the growth of acne-related pathogenic flora in the follicular sebum, inhibiting bacteria and diminishing inflammation; 3) good acne inhibiting activity, and can improve skin acne caused by cosmetics; 4) the acne removing effect is synergistically improved through three ways of promoting penetration and absorption, dredging pores and improving follicular keratosis.
Preferably, the acne-removing composition A comprises the following components in parts by weight: 10-20 parts of salvia miltiorrhiza root extract, 2-4 parts of clove bud extract, 1-3 parts of scutellaria baicalensis root extract, 1-3 parts of angelica sinensis root extract, 0.5-2 parts of licorice root extract and 0.5-2 parts of centella asiatica extract.
More preferably, the acne-removing composition a comprises the following components in parts by weight: 15 parts of salvia miltiorrhiza root extract, 3 parts of clove bud extract, 2 parts of scutellaria baicalensis root extract, 2 parts of angelica root extract, 1 part of liquorice root extract and 1 part of centella extract. When the extracts are mixed according to the proportion, the extracts can fully exert respective functions.
Preferably, the acne removing composition A accounts for 0.4-0.6% of the acne removing cleansing milk in percentage by weight. The acne-removing composition A can achieve the acne-removing effect in the facial cleanser by adopting the addition amount, and the aim of efficient utilization is fulfilled.
Preferably, the facial cleanser further comprises an acne-removing composition B; the acne-removing composition B comprises oldenlandia diffusa extract, honeysuckle extract and Chinese honey locust seed extract.
The oldenlandia diffusa extract has anti-inflammatory and antibacterial effects, and has different degrees of antibacterial and bactericidal effects on cocci and bacilli; the honeysuckle stem has the functions of antibiosis and antiphlogosis, and has obvious bacteriostatic activity on staphylococcus aureus and propionibacterium acnes. The acne-removing composition B has a remarkable inhibiting effect on 5 alpha-reductase by matching of the extracts, can relieve acne symptoms, can reduce acne marks, and has an oil control effect. The acne-removing composition B and the acne-removing composition A are matched together, so that acne can be effectively relieved, cells can be helped to regenerate, damaged cell tissues can be repaired, fibrous tissue reconstruction is activated, the skin is smooth and fine, roughness is smoothed, moisture and nutrition are supplemented, the skin is soft, moist and elastic, and acne-removing is realized.
Preferably, the acne-removing composition B comprises the following components in parts by weight: 2-4 parts of oldenlandia diffusa extract, 2-4 parts of honeysuckle extract and 0.5-2 parts of Chinese honey locust seed extract. When the extracts are mixed according to the proportion, the extracts can fully exert respective functions.
More preferably, the acne-removing composition B comprises the following components in parts by weight: 3 parts of oldenlandia diffusa extract, 3 parts of honeysuckle extract and 1 part of Chinese honey locust seed extract.
Preferably, the acne removing composition B accounts for 0.4-0.6% of the acne removing facial cleanser by weight. The acne-removing composition B can achieve the effect of removing acne marks in the facial cleanser by adopting the addition amount, and the efficient utilization of the composition B is realized.
Preferably, the facial cleanser further comprises a surfactant; the surfactant comprises sodium methyl cocoyl taurate, sodium lauroyl sarcosinate, cocamidopropyl betaine, polyquaternium-4/hydroxypropyl starch copolymer and dextran hydroxypropyl trimethyl ammonium chloride; the weight percentage of the components of the surfactant in the cleansing milk is as follows: 4-6% of methyl cocoyl sodium taurate, 1.6-2.4% of sodium lauroyl sarcosinate, 1.5-2% of cocamidopropyl betaine, 0.05-0.1% of polyquaternary ammonium salt-4/hydroxypropyl starch copolymer and 0.05-0.1% of dextran hydroxypropyl trimethyl ammonium chloride.
When the surfactant is adopted in the facial cleanser, the facial cleanser is stable in property, has good cleaning power and no irritation, is not tight after washing, and can maintain the water-oil balance of skin.
Preferably, the facial cleanser further comprises a skin-activating component; the facial cleanser also comprises a skin activating component and an emollient; the skin-active ingredient comprises menthol; the weight percentage of the menthol in the cleansing milk is 0.04-0.06%; the emollient comprises myristic acid, stearic acid, palmitic acid, lauric acid, and glyceryl stearate; the skin lotion comprises the following components in percentage by weight: 10-14% of myristic acid, 8-12% of stearic acid, 4-6% of palmitic acid, 2.5-3.5% of lauric acid and 0.5-1% of glyceryl stearate.
The skin activating component can activate the skin, thoroughly infiltrate the stratum corneum, promote the skin to absorb the acne-removing composition A and the acne-removing composition B, improve the keratinization of hair follicles, and more effectively inhibit bacteria, diminish inflammation and control oil, and the emollient can prevent the skin from drying after the facial cleanser is used, and soften the stratum corneum.
Preferably, the facial cleanser further comprises a humectant and an emulsifier; the humectant comprises glycerin; the emulsifier comprises behenate, glyceryl myristate and PEG-250 distearate.
Preferably, the weight percentage of the glycerin in the facial cleanser is 13-17%; the weight percentage of each component in the emulsifier in the facial cleanser is as follows: 1.2-1.8% of behenyl alcohol behenate, 0.5-1.4% of glyceryl myristate and 0.4-0.8% of PEG-250 distearate.
Preferably, the facial cleanser comprises the following components in percentage by weight: 0.4-0.6% of acne-removing composition A, 0.4-0.6% of acne-removing composition B, 4-6% of methyl cocoyl sodium taurate, 1.6-2.4% of sodium lauroyl sarcosinate, 1.5-2% of cocamidopropyl betaine, 0.05-0.1% of polyquaternary ammonium salt-4/hydroxypropyl starch copolymer, 0.05-0.1% of dextran hydroxypropyl trimethyl ammonium chloride, 0.04-0.06% of menthol, 13-17% of glycerol, 10-14% of myristic acid, 8-12% of stearic acid, 4-6% of palmitic acid, 2.5-3.5% of lauric acid, 0.5-1% of glycerol stearate, 1.2-1.8% of behenate, 0.5-1.4% of glyceryl myristate and 0.4-0.8% of PEG-250 distearate. The facial cleanser with the proportion has a good cleaning effect, and can adjust the water-oil balance of skin, diminish inflammation and fade acne marks.
More preferably, the facial cleanser comprises the following components in percentage by weight: 0.5% of acne-removing composition A, 0.5% of acne-removing composition B, 5% of sodium methyl cocoyl taurate, 2% of sodium lauroyl sarcosinate, 1.8% of cocamidopropyl betaine, 0.08% of polyquaternium-4/hydroxypropyl starch copolymer, 0.08% of dextran hydroxypropyl trimethyl ammonium chloride, 0.05% of menthol, 15% of glycerol, 12% of myristic acid, 10% of stearic acid, 5% of palmitic acid, 3% of lauric acid, 0.8% of glyceryl stearate, 1.5% of behenate, 0.9% of glyceryl myristate and 0.6% of PEG-250 distearate. The acne removing effect of the facial cleanser adopting the formula is optimal.
Preferably, the facial cleanser further comprises a preservative; the preservative is a mixture of methylparaben and methylisothiazolinone.
Besides the specific requirements of the components, other auxiliary components such as pH regulator, essence, pigment and the like can be added or used within the range of not damaging the effect of the invention, and the common content can be selected by the skilled in the art according to the conventional standard.
The invention has the beneficial effects that: the invention provides acne-removing facial cleanser, which is prepared by adding mild plant extract components and matching with basic raw materials, can penetrate into the skin bottom to remove skin stains, control oil deeply, adjust the water-oil balance of the skin, remove acnes, fade acne marks, repair damaged skin and restore the natural health state of the skin.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1 to 7
Examples 1 to 7 are examples of the acne removing facial cleanser provided by the invention, and the formula of the acne removing facial cleanser provided by examples 1 to 6 is shown in table 1. The formula of the acne removing facial cleanser described in example 7 is shown in table 2. In embodiments 1 to 7, the acne-removing composition a comprises the following components in parts by weight: 15 parts of salvia miltiorrhiza root extract, 3 parts of clove bud extract, 2 parts of scutellaria baicalensis root extract, 2 parts of angelica root extract, 1 part of liquorice root extract and 1 part of centella extract; the acne-removing composition B comprises the following components in parts by weight: 3 parts of oldenlandia diffusa extract, 3 parts of honeysuckle extract and 1 part of Chinese honey locust seed extract.
The preparation method of the acne-removing facial cleanser disclosed in embodiment 1-7 comprises the following steps:
s1, cleaning the production pot, and disinfecting for later use;
s2, adding lauric acid, myristic acid, palmitic acid, stearic acid, behenyl behenate, glyceryl myristate, PEG-250 distearate, glyceryl stearate, ethylene glycol distearate and propyl hydroxybenzoate into a main phase pan, heating to 75-80 ℃, and completely dissolving;
s3, pumping water into a water kettle, adding dissolved potassium hydroxide, sequentially adding glycerol and EDTA disodium, heating to 75 ℃, and uniformly stirring;
s4, pumping the material obtained in the step S3 into a main phase pot, adding sodium methyl cocoyl taurate, sodium lauroyl sarcosinate and cocamidopropyl betaine, and performing heat preservation and saponification for 40 minutes;
s5, adding water, polyquaternium-4/hydroxypropyl starch copolymer and dextran hydroxypropyl trimethyl ammonium chloride, stirring uniformly, cooling to about 36-38 ℃, stopping cooling, keeping the temperature, continuing to stir slowly for 30 minutes, paying attention to the fact that the speed cannot be fast until pearls are completely separated out and completely form paste, adding methylisothiazolinone, and stirring uniformly;
s6, finally adding the dissolved essence, the melaleuca alternifolia leaf oil and the menthol, stirring uniformly, sampling, checking the plate, and discharging after the plate is qualified to obtain the acne-removing facial cleanser.
Table 1 formula of acne removing facial cleanser described in examples 1 to 6
Comparative examples 1 and 2
The formula of the acne-removing facial cleanser in comparative examples 1 and 2 is shown in table 2. The acne-removing composition B comprises the following components in parts by weight: 3 parts of oldenlandia diffusa extract, 3 parts of honeysuckle extract and 1 part of Chinese honey locust seed extract. The preparation method of the acne-removing facial cleanser in the comparative examples 1 and 2 is the same as that in the examples 1-6.
Table 2 formula of acne removing face cleansing cream described in example 7, comparative examples 1 and 2
The products of examples 1-7 and comparative examples 1 and 2 are tested to meet the related requirements of QB/T1857-.
Example 8
Product safety evaluation (human body skin patch experiment)
Firstly, testing a test article: acne-removing facial cleanser prepared in examples 1-7 and comparative examples 1 and 2
Number of test population: 90 people, female
Age: between 12 and 30 years old
Health condition: the skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject.
Grouping: 9 groups of 10 people each, mean age 25 ± 2 years.
Secondly, a spot pasting method: selecting a qualified spot tester, dripping 0.020 g-0.025 g of a tested object into the spot tester in a closed spot patch test mode, externally applying a special adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions after 0.5, 6, 12, 24 and 48 hours after the tested object is removed respectively, and recording the results according to the skin reaction grading standard in the cosmetic hygiene standard.
Thirdly, experimental results: the result of the human body skin patch test shows that: each group of subjects pass the patch test of the acne-removing facial cleanser described in examples 1-9 and comparative examples 1 and 2, and skin reactions are observed at 0.5, 6, 12, 24 and 48 hours, wherein 0 case has adverse skin reactions, which indicates that the acne-removing facial cleanser is safe to use.
Example 9
Test of bacteriostatic Effect
First, test materials
1. Test strains: propionibacterium acnes (ATCC 6919).
2. Test samples: storing samples S1, S2, S3, S4, S5, S6, S7, D1 and D2 at 4 ℃ for later use, wherein S1, S2, S3, S4, S5, S6, S7, D1 and D2 respectively correspond to the proportions of the acne-removing ingredients in examples 1-7 and comparative examples 1 and 2.
3. Culture medium: the pH of the culture medium for the acne propionibacterium acnes is adjusted to 6.6-7.0. Wherein 15g/L of agar is added into the solid culture medium.
Second, test method
1. Preparing and inoculating a bacterial suspension: taking 0.1mL of the frozen and preserved bacterial suspension to be placed in 5mL of propionibacterium acnes liquid culture medium, and culturing for 2d under the anaerobic condition at 37 ℃ to obtain experimental bacterial suspension.
2. Preparing a liquid medicine: s1, S2, S3, S4, S5, S6, S7, D1, and D2 were diluted with physiological saline to test concentrations of 0.1%, respectively, and then diluted in a gradient. The gradient dilution concentrations of the first test were 100% (sample stock solution), 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, respectively. The concentration of the second test retest gradient dilution is 10%, 8%, 6%, 4% and 2%, respectively.
3. Preparing bacterial liquid: the bacterial suspension was diluted with Propionibacterium acnes liquid medium to a final bacterial concentration of l06CFU/mL。
4. Culturing and judging results: adding 100 μ L of bacteria solution and 100 μ L of liquid medicine into the micropores, setting negative control without bacteria and normal growth control without liquid medicine, making 3 parallels for each medicine, and taking average value. Anaerobic incubation is carried out at 37 ℃, and the result is observed after 48 hours. Whether turbidity exists or not is judged by naked eyes, and data are read by a direct method. The premise of result judgment is that the growth contrast is good, the blank contrast aseptically grows clearly, and the growth of bacteria in other holes is inhibited along with the increase of the drug concentration gradient.
TABLE 3 results of the first bacteriostatic gradient test
Concentration gradient | S1 | S2 | S3 | S4 | S5 | S6 | S7 | D1 | D2 |
100% | — | — | — | — | — | — | — | — | — |
50% | — | — | — | — | — | — | — | — | — |
25% | — | — | — | — | — | — | — | + | + |
12.5% | — | — | — | — | — | — | + | + | + |
6.25% | — | + | + | + | + | + | + | + | + |
3.125% | + | + | + | + | + | + | + | + | + |
1.56% | + | + | + | + | + | + | + | + | + |
0.78% | + | + | + | + | + | + | + | + | + |
Note: wherein "+" represents the presence of bacteria and "-" represents the absence.
TABLE 4 results of the second bacteriostatic gradient test
Concentration gradient | S1 | S2 | S3 | S4 | S5 | S6 | S7 | D1 | D2 |
10% | — | — | — | — | — | — | + | + | + |
8% | — | — | — | + | + | + | + | + | + |
6% | — | + | + | + | + | + | + | + | + |
4% | + | + | + | + | + | + | + | + | + |
2% | + | + | + | + | + | + | + | + | + |
1% | + | + | + | + | + | + | + | + | + |
Note: wherein "+" represents the presence of bacteria and "-" represents the absence.
5. Results
As can be seen from the results in Table 3, the 0.1% solutions of examples 1-6, when diluted to a concentration of 12.5% or more, have good inhibitory effect on Propionibacterium acnes, whereas the 25% dilution of example 7 and above can achieve the effect, and the comparative examples 1 and 2 require concentrations of 50% or more. The results in table 4 show that the bacteriostatic concentration of the solutions in examples 1 to 6 can be achieved by 10% of the diluent, and the bacteriostatic concentration of the solution in example 1 can achieve the bacteriostatic effect by 6% of the diluent. According to the results, the minimal addition of the acne removing component is about 0.01%, so that the effect of inhibiting propionibacterium acnes can be basically achieved, and the acne removing component has a stronger antibacterial effect when the acne removing composition A and the acne removing composition B are used together than when the acne removing component is used alone.
Example 10
Clinical tests were carried out on the facial cleansers of examples 1-7 and comparative examples 1 and 2, specifically as follows:
the number of people: 90 people divided into 9 groups of 10 people each with a ratio of 1:1, and acne on face
Time: 21 days
The part: face part
Sample preparation: facial cleanser as described in examples 1-7 and comparative examples 1 and 2
Evaluation: evaluation and photographing according to the GAGS scoring method were performed (photograph not shown):
the GAGS scoring method is a Global Acid Grading System (GAGS) of an Acne comprehensive Grading System proposed by Doshi et al in 1997, is a scoring method, and has the characteristics of accuracy, strong consistency, quickness, good overall evaluation effect and the like. The method specifically comprises the following steps: according to the density, distribution and approximate area of the pilosebaceous unit, the good hair part of the acne is divided into 6 areas: zone i, forehead, zone ii: right cheek, zone iii: left cheek, region iv: nose, chin zone v, zone vi: chest and upper back. The scores of factors in the I, II and III zones are 2, the scores of factors in the IV and V zones are 1, the score of factors in the VI zone is 3, and the score of the skin loss of each zone is (the principle is that the local most serious skin loss determines the score of the zone): 0 is no skin damage; 1 is more than or equal to 1 acne; 2 or more than 1 pimple; 3, more than or equal to 1 abscess; 4 is more than or equal to 1 node. The total score of each subarea is factor score multiplied by skin damage score, and the sum of the total scores of different subareas is the comprehensive score.
The evaluation results are shown in Table 5.
TABLE 5 GAGS score evaluation results of the face cleansers described in examples 1 to 7 and comparative examples 1 and 2
Group of | Before use | 3 days | 7 days | 14 days | 21 days |
Example 1 | 18.0 | 15.3 | 14.0* | 11.8** | 10.8** |
Example 2 | 18.6 | 16.9 | 15.5* | 14.2** | 13.2** |
Example 3 | 18.8 | 16.8 | 15.3* | 14.5** | 13.5** |
Example 4 | 18.5 | 16.3 | 15.2* | 13.8** | 12.8** |
Example 5 | 18.6 | 17.0 | 15.1* | 14.5** | 13.0** |
Example 6 | 17.6 | 15.9 | 14.8* | 14.1** | 13.0** |
Example 7 | 17.8 | 16.6 | 15.5* | 14.9** | 14.1** |
Comparative example 1 | 18.2 | 17.0 | 16.2 | 15.8* | 15.0** |
Comparative example 2 | 18.0 | 17.5 | 17.0 | 16.6 | 16.1 |
P < 0.05VS before use, P < 0.01VS before use
As can be seen from Table 3, the facial cleansers described in examples 1-7 showed a significant decrease in acne score after 7 days (P < 0.05) and a significant decrease at 14 and 21 days of use, as compared to pre-use. As can be seen from the table, compared with example 1, examples 4 to 6 have higher comprehensive scores after 21 days of use, which indicates that the acne-removing compositions a and B need to be in a certain proportion to exert better acne-removing effects; compared with example 1, the acne removing effect of example 7 and comparative examples 1 and 2 is poorer, which shows that the acne removing composition A and the acne removing composition B are better when used together, and compared with examples 4-6, the facial cleanser of example 1 has better acne removing effect.
Example 11
Evaluation of product Effect
Firstly, testing a test article: examples 1-3 prepared anti-acne facial cleanser
Second, the tested population
Sex number: 90 people with a male to female ratio of about 1:1
Age: between 12 and 30 years old
Health condition: the skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject.
Grouping: divided into 3 groups of 30 persons each, with a mean age of 25 ± 2 years.
Thirdly, a testing method: the acne removing facial cleanser prepared in the examples 1-3 is used for observing and feeling the using effect. The using method comprises the following steps: after the face of a subject is cleaned, a proper amount of the acne-removing facial cleanser is uniformly smeared on the face and is massaged until the acne-removing facial cleanser is absorbed. The medicine is taken once a day, morning and evening, and is used for one month, and is checked at least once a week to know whether systemic and local adverse reactions exist, and the result is recorded in detail.
The test evaluation results are shown in tables 6-8.
Table 6 example 1 summary of trial (one month) feedback of anti-acne facial cleanser
Table 7 example 2 summary of trial (one month) feedback of anti-acne facial cleanser
Table 8 example 3 summary of trial (one month) feedback for anti-acne facial cleanser
As can be seen from tables 6 to 8, the acne-removing facial cleanser disclosed by the embodiments 1 to 3 is widely popular and approved by the subjects, and the subjects show that the acne-removing facial cleanser disclosed by the invention is mild in texture, and can astringe pores, soothe skin, adjust the water-oil balance of the skin, deeply repair and condition the acne skin. The acne removing facial cleanser in example 1 has the highest acceptance among examples 1 to 3. Meanwhile, no allergy phenomenon occurs in all the subjects, and the conditions of skin itch, stabbing pain, red swelling and the like do not occur. Therefore, the acne-removing facial cleanser is mild and safe and can be used for a long time.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (4)
1. The acne-removing facial cleanser is characterized by comprising an acne-removing composition A; the acne-removing composition A comprises the following components in parts by weight: 15 parts of salvia miltiorrhiza root extract, 3 parts of clove bud extract, 2 parts of scutellaria baicalensis root extract, 2 parts of angelica root extract, 1 part of liquorice root extract and 1 part of centella extract; the weight percentage content of the acne-removing composition A in the acne-removing facial cleanser is 0.5%; the facial cleanser also comprises an acne-removing composition B; the acne-removing composition B comprises the following components in parts by weight: 3 parts of oldenlandia diffusa extract, 3 parts of honeysuckle extract and 1 part of Chinese honey locust seed extract; the weight percentage content of the acne-removing composition B in the acne-removing facial cleanser is 0.5%; the facial cleanser also comprises a surfactant; the surfactant comprises sodium methyl cocoyl taurate, sodium lauroyl sarcosinate, cocamidopropyl betaine, polyquaternium-4/hydroxypropyl starch copolymer and dextran hydroxypropyl trimethyl ammonium chloride; the weight percentage of the components of the surfactant in the cleansing milk is as follows: 5% of sodium methyl cocoyl taurate, 2% of sodium lauroyl sarcosinate, 1.8% of cocamidopropyl betaine, 0.08% of polyquaternium-4/hydroxypropyl starch copolymer and 0.08% of dextran hydroxypropyl trimethyl ammonium chloride; the facial cleanser also comprises a skin activating component and an emollient; the skin-active ingredient comprises menthol; the weight percentage content of the menthol in the cleansing milk is 0.05 percent; the emollient comprises myristic acid, stearic acid, palmitic acid, lauric acid, and glyceryl stearate; the skin lotion comprises the following components in percentage by weight: myristic acid 12%, stearic acid 10%, palmitic acid 5%, lauric acid 3% and glyceryl stearate 0.8%.
2. The acne-removing facial cleanser of claim 1, further comprising a humectant and an emulsifier; the humectant comprises glycerin; the emulsifier comprises behenate, glyceryl myristate and PEG-250 distearate.
3. The acne-removing facial cleanser according to claim 1, wherein the facial cleanser comprises the following components in percentage by weight: 0.5% of acne-removing composition A, 0.5% of acne-removing composition B, 5% of sodium methyl cocoyl taurate, 2% of sodium lauroyl sarcosinate, 1.8% of cocamidopropyl betaine, 0.08% of polyquaternium-4/hydroxypropyl starch copolymer, 0.08% of dextran hydroxypropyl trimethyl ammonium chloride, 0.05% of menthol, 13-17% of glycerol, 12% of myristic acid, 10% of stearic acid, 5% of palmitic acid, 3% of lauric acid, 0.8% of glycerol stearate, 1.2-1.8% of behenate, 0.5-1.4% of glyceryl myristate and 0.4-0.8% of PEG-250 distearate.
4. The acne-removing facial cleanser according to claim 3, wherein the facial cleanser comprises the following components in percentage by weight: 0.5% of acne-removing composition A, 0.5% of acne-removing composition B, 5% of sodium methyl cocoyl taurate, 2% of sodium lauroyl sarcosinate, 1.8% of cocamidopropyl betaine, 0.08% of polyquaternium-4/hydroxypropyl starch copolymer, 0.08% of dextran hydroxypropyl trimethyl ammonium chloride, 0.05% of menthol, 15% of glycerol, 12% of myristic acid, 10% of stearic acid, 5% of palmitic acid, 3% of lauric acid, 0.8% of glyceryl stearate, 1.5% of behenate, 0.9% of glyceryl myristate and 0.6% of PEG-250 distearate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811207350.XA CN109157451B (en) | 2018-10-16 | 2018-10-16 | Acne-removing facial cleanser |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811207350.XA CN109157451B (en) | 2018-10-16 | 2018-10-16 | Acne-removing facial cleanser |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109157451A CN109157451A (en) | 2019-01-08 |
CN109157451B true CN109157451B (en) | 2021-06-15 |
Family
ID=64878421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811207350.XA Active CN109157451B (en) | 2018-10-16 | 2018-10-16 | Acne-removing facial cleanser |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109157451B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109806202A (en) * | 2019-04-01 | 2019-05-28 | 贵州阿斯科科技开发有限公司 | A kind of Chinese herbal medicine anti-acne facial cleanser and preparation method thereof |
CN110585349A (en) * | 2019-09-30 | 2019-12-20 | 广东密尚生物科技有限公司 | Acne-removing and bacterium-inhibiting composition and preparation method and application thereof |
CN110721139A (en) * | 2019-10-30 | 2020-01-24 | 广东密尚生物科技有限公司 | Oil-controlling acne-removing composition and preparation method and application thereof |
CN110652486A (en) * | 2019-11-12 | 2020-01-07 | 江苏逸洁生物科技股份有限公司 | Medicinal acne-removing gel |
WO2021262536A1 (en) * | 2020-06-23 | 2021-12-30 | Rohm And Haas Company | Method of making and using a skin moisturizing formulation |
CN111658578A (en) * | 2020-07-29 | 2020-09-15 | 雷菁 | Oil-control acne-removing facial cleanser and production method thereof |
CN114762667A (en) * | 2021-01-14 | 2022-07-19 | 江西初芙化妆品有限公司 | Acne-removing facial cleanser and preparation method thereof |
CN114762671A (en) * | 2021-01-14 | 2022-07-19 | 江西初芙化妆品有限公司 | Oil-control cleansing cream and preparation method thereof |
CN114796063A (en) * | 2022-06-02 | 2022-07-29 | 广州一一生物技术有限公司 | Mild and antibacterial facial cleanser and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107773600A (en) * | 2016-08-26 | 2018-03-09 | 莱博药妆技术(上海)股份有限公司 | A kind of preparation method of acne compound |
-
2018
- 2018-10-16 CN CN201811207350.XA patent/CN109157451B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107773600A (en) * | 2016-08-26 | 2018-03-09 | 莱博药妆技术(上海)股份有限公司 | A kind of preparation method of acne compound |
Non-Patent Citations (1)
Title |
---|
自然之名茶树控油净痘洁面乳;上海萧雅生物科技股份有限公司;《http://ftba.nmpa.gov.cn:8181/ftban/itownet/hzp_ba/fw/pz.jsp?processid=20180413111》;20180421;正文 * |
Also Published As
Publication number | Publication date |
---|---|
CN109157451A (en) | 2019-01-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN109157451B (en) | Acne-removing facial cleanser | |
CN108969429B (en) | Acne removing essence | |
CN109157450B (en) | Acne-removing essence | |
CN109260075B (en) | Acne-removing conditioning water | |
US10675488B2 (en) | Acne removing skin care product and preparation method thereof | |
WO2024045952A1 (en) | Recombinant collagen-containing composition having effects of repairing and soothing, eye cream containing same, preparation method therefor, and use thereof | |
CN110755331B (en) | Antibacterial infant washing and caring preparation and application thereof | |
CN111529470B (en) | Compound acne-removing and allergy-relieving gel and preparation method thereof | |
CN112426386A (en) | Oil-control acne-removing efficacy composition and gel | |
CN111743830A (en) | Acne-removing composition and application thereof | |
CN111773272A (en) | External compound formula for treating acne and preparation method thereof | |
CN112618456A (en) | Oil control convergence set and using method thereof | |
CN116549373A (en) | Composition for balancing skin grease secretion and preparation method and application thereof | |
CN111671692A (en) | Acne-removing composition and preparation method and application thereof | |
CN108295022B (en) | Acne-removing composition and preparation method thereof | |
CN112516066B (en) | Oil control composition and application thereof in cosmetics | |
CN106137839A (en) | A kind of acne-removing liquid | |
CN115192488B (en) | Acne-removing and skin-refreshing essence containing betaine salicylate and preparation method thereof | |
CN116421514A (en) | Acne-removing composition and eye cream for non-irritation of eyes, and preparation method and application of acne-removing composition and eye cream | |
CN109568230A (en) | A kind of Chinese medicine cosmetic of the anti-aging of moisturizing whitening | |
CN110025508A (en) | A kind of essence cream and preparation method thereof preventing striae of pregnancy generation | |
CN106511153B (en) | Nanometer composition with acne removing effect and cosmetic or skin care product thereof | |
CN112807238A (en) | Anti-inflammatory and soothing repair gel for skin and preparation method thereof | |
CN111939097A (en) | Moisturizing and allergy-relieving composition and application thereof | |
CN114712273A (en) | Acne-removing repairing composition and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |