CN109157451A - A kind of anti-acne mildy wash - Google Patents
A kind of anti-acne mildy wash Download PDFInfo
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- CN109157451A CN109157451A CN201811207350.XA CN201811207350A CN109157451A CN 109157451 A CN109157451 A CN 109157451A CN 201811207350 A CN201811207350 A CN 201811207350A CN 109157451 A CN109157451 A CN 109157451A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The invention discloses a kind of anti-acne mildy wash, include acne-removing composition A;The acne-removing composition A includes Radix Salviae Miltiorrhizae root extract, cloves alabastrum extract, radix scutellariae root extract, Angelica roots, licorice root extract and Gotu Kola P.E.The present invention cooperates basic material, anti-acne mildy wash is made, can go deep into flesh bottom and remove skin spot by adding mild plant extraction ingredient, deep layer oil-control is adjustable the water and oil balance of skin, removes small pox, desalinate acne print, repairs impaired skin, restore skin natural health state.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of anti-acne mildy wash.
Background technique
With the development of economy with the continuous improvement of quality of life, the anti-acne of Chinese whelk patient is realized to be improved year by year.
Chinese skin disease association, the joint investigation of adolescents in China federation are the results show that the disease incidence of China's whelk is in rise year by year
The problem of trend, 80% or more young people encountered whelk to some extent, the state of an illness it is more serious account for the 1/3 of young people with
On.
Acne is being commonly called as acne, is called " whelk ", " dark sore " or " acne ", is due to hair follicle and sebum adenemphraxis, hair
A kind of skin disease that inflammation is caused.When puberty, intracorporal hormone can stimulate hair growth, promote smegma more heavy wool
Therefore rouge, hair and sebaceous glands accumulate many substances, since this symptom is common in youth of both sexes, so just it is referred to as " the youth
Acne ".
Whelk is a kind of common chronic dermatosis, and juvenile onset number highest is mainly in face and chest and back, table
It is now the various skin injuries such as blackhead, papule, running sore, tubercle, tumour and scar, hinders appearance.The main reason of green whelk
It is that the clogging of pores as caused by the accumulation of sebum causes sebum to accumulate the acne to be formed, once infection occur will be very short
Appearance deterioration forms serious tumour in time or this is abscess.
Acne itself is not fearful, and maximum harm is not in time or acne print, acne hole, acne are easily left in irregular treatment
Scar seriously affects image.Acne hole acne scar be really inflammation invasion plus with hand squeeze the equivalent damage epidermis of skin, skin corium with
And the subcutaneous tissue of more lower section, cause the generation of the destruction of skin, the defect of tissue and scar.These problems not only serious shadow
Appearance is rung, is also acquired a certain degree of difficulty in the treatment.
So for small pox crowd, in order to completely remove small pox acne print, in addition to paying attention to diet, living habit,
A safely and effectively product for resolving poxes is essential.
Summary of the invention
A kind of anti-acne mildy wash is provided it is an object of the invention to overcome the shortcomings of the prior art place.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of anti-acne mildy wash, include acne-removing composition A;
The acne-removing composition A includes Radix Salviae Miltiorrhizae root extract, cloves alabastrum extract, radix scutellariae root extract, Angelica roots, Radix Glycyrrhizae
Root extract and Gotu Kola P.E.
The present invention uses above-mentioned acne-removing composition A, and Radix Salviae Miltiorrhizae root extract has effects that antibacterial, oil-control, anti-inflammatory, angelica root
Extract has the effect of activating microcirculation and removing stasis medicinal, improves follicular keratosis, and licorice root extract and Gotu Kola P.E have reconciliation, repair
The effect of, and cloves alabastrum extract and radix scutellariae root extract can promote Radix Salviae Miltiorrhizae root extract, Angelica roots, licorice
The Transdermal absorption of extract and Gotu Kola P.E etc. dredges pore, to realize " safely, effectively " anti-acne.Acne-removing composition A
It has the following characteristics that and 1) inhibits 5α-reductase activity, balance sebum secretion;2) inhibit acne correlation pathogen in hair follicle sebum
All living creatures is long, inhibiting bacteria and diminishing inflammation;3) good suppression acne activity, skin acne state caused by improving because of cosmetics;4) by promoting to inhale thoroughly
It receives, dredging pore, improve three kinds of approach collaboration promotion acne-removings of follicular keratosis.
Preferably, in the acne-removing composition A each component parts by weight are as follows: 10~20 parts of Radix Salviae Miltiorrhizae root extract, lilac
2~4 parts of flower bud extract, 1~3 part of radix scutellariae root extract, 1~3 part of Angelica roots, 0.5~2 part of licorice root extract and product
Avenge careless 0.5~2 part of extract.
It is highly preferred that in the acne-removing composition A each component parts by weight are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, cloves bud
3 parts of extract, 2 parts of radix scutellariae root extract, 2 parts of Angelica roots, 1 part of licorice root extract and 1 part of Gotu Kola P.E.Respectively
When its extract uses said ratio, each extract can be made to give full play to respective effect.
Preferably, weight percentage of the acne-removing composition A in the anti-acne mildy wash is 0.4~0.6%.Institute
The effect of its anti-acne can be realized in mildy wash using above-mentioned additive amount by stating acne-removing composition A, achieve the purpose that efficiently to utilize.
Preferably, the mildy wash also includes acne-removing composition B;The acne-removing composition B is extracted comprising oldenlandia diffusa
Object, honeysuckle extract and fruitlet Chinese honey locust seed extract.
Herba hedyotis diffusae extract has anti-inflammatory and antibacterial action, all has different degrees of antibacterial to coccus and bacillus and kills
Bacterium effect;Caulis lonicerae has antibacterial and antiinflammation, has apparent Antibacterial Activity to S. aureus L-forms and propionibacterium acnes.Institute
Each extract cooperation of acne-removing composition B is stated, there is significant inhibiting effect to 5α-reductase, acne symptom can be mitigated, desalinate
Acne print, while having effects that oil-control.Acne-removing composition B and acne-removing composition A cooperate jointly, can effectively mitigate small pox, help thin
Born of the same parents live again, and repair impaired cell tissue, and activation fibr tissue is rebuild, and it is smoothly fine and smooth to go back skin, smooth it is coarse, keep the skin wet and
Nutrition enables skin softness, water moisten, is flexible, realizes that small pox is eliminated completely.
Preferably, in the acne-removing composition B each component parts by weight are as follows: 2~4 parts of herba hedyotis diffusae extract, honeysuckle
0.5~2 part of 2~4 parts of extract and fruitlet Chinese honey locust seed extract.When its each extract uses said ratio, each extraction can be made
Object gives full play to respective effect.
It is highly preferred that in the acne-removing composition B each component parts by weight are as follows: 3 parts of herba hedyotis diffusae extract, honeysuckle mention
Take 1 part of 3 parts of object and fruitlet Chinese honey locust seed extract.
Preferably, weight percentage of the acne-removing composition B in the anti-acne mildy wash is 0.4~0.6%.Institute
Stating acne-removing composition B can realize that it desalinates the effect of acne print using above-mentioned additive amount in mildy wash, realize that composition B's is efficient
It utilizes.
Preferably, the mildy wash also includes surfactant;The surfactant includes methyl cocoyl ox sulphur
Sour sodium, sodium lauroyl sarcosine, Cocoamidopropyl betaine, -4/ hydroxypropul starch copolymer of polyquaternium and glucan hydroxyl
Hydroxypropyltrimonium chloride;Weight percentage of each ingredient of surfactant in the mildy wash are as follows: methyl cocoyl
Acyl taurines sodium 4~6%, sodium lauroyl sarcosine 1.6~2.4%, Cocoamidopropyl betaine 1.5~2%, polyquaternary amine
- 4/ hydroxypropul starch copolymer 0.05~0.1% of salt and glucan hydroxypropyl-trimethyl ammonium chloride 0.05~0.1%.
When using above-mentioned surfactant in the mildy wash, the character of mildy wash is stablized, have preferable cleaning force and
It is nonirritant and not tight after washing, the water and oil balance of skin can be maintained.
Preferably, the mildy wash also includes skin-active ingredient;The mildy wash also includes skin-active ingredient and emollient;It is described
Skin-active ingredient includes menthol;Weight percentage of the menthol in the mildy wash is 0.04~0.06%;It is described
Emollient includes myristic acid, stearic acid, palmitinic acid, lauric acid and stearine;Each ingredient of emollient is described
Weight percentage in mildy wash are as follows: myristic acid 10~14%, stearic acid 8~12%, palmitinic acid 4~6%, lauric acid
2.5~3.5% and stearine 0.5~1%.
Skin-active ingredient can infiltrate thoroughly cuticula with Cucumber Extract, promote skin to acne-removing composition A, acne-removing composition B
Absorb, improve hair follicle keratinization, can more effectively antibacterial, anti-inflammatory and oil-control, emollient can make with skin in mildy wash
It is not dried after, cutin-softening layer.
Preferably, the mildy wash also includes moisturizer and emulsifier;The moisturizer includes glycerol;The emulsifier packet
Containing behenyl behenate, glycerine myristate ester and PEG-250 distearate.
Preferably, weight percentage of the glycerol in the mildy wash is 13~17%;It is each in the emulsifier
Weight percentage of the ingredient in the mildy wash are as follows: behenyl behenate 1.2~1.8%, glycerine myristate ester 0.5
~1.4% and PEG-250 distearate 0.4~0.8%.
Preferably, the mildy wash includes the component of following weight percentage: acne-removing composition A 0.4~0.6%, being dispelled
Acne composition B 0.4~0.6%, sodium methyl cocoyl taurate 4~6%, sodium lauroyl sarcosine 1.6~2.4%, cocounut oil
Amido propyl betaine 1.5~2%, -4/ hydroxypropul starch copolymer 0.05~0.1% of polyquaternium, glucan hydroxypropyl three
Ammonio methacrylate 0.05~0.1%, menthol 0.04~0.06%, glycerol 13~17%, myristic acid 10~14%, stearic acid
8~12%, palmitinic acid 4~6%, lauric acid 2.5~3.5%, stearine 0.5~1%, behenyl behenate 1.2
~1.8%, glycerine myristate ester 0.5~1.4%, PEG-250 distearate 0.4~0.8%.Using the clean of said ratio
Face cream has preferable cleaning effect, and is adjustable the water and oil balance of skin, the effect of anti-inflammatory and desalination acne print.
It is highly preferred that the mildy wash includes the component of following weight percentage: acne-removing composition A 0.5%, anti-acne
Composition B 0.5%, sodium methyl cocoyl taurate 5%, sodium lauroyl sarcosine 2%, Cocoamidopropyl betaine
1.8%, -4/ hydroxypropul starch copolymer 0.08% of polyquaternium, glucan hydroxypropyl-trimethyl ammonium chloride 0.08%, menthol
0.05%, glycerol 15%, myristic acid 12%, stearic acid 10%, palmitinic acid 5%, lauric acid 3%, stearine
0.8%, behenyl behenate 1.5%, glycerine myristate ester 0.9%, PEG-250 distearate 0.6%.Using above-mentioned
The mildy wash anti-acne effect of formula is best.
Preferably, the mildy wash further includes preservative;The preservative is methyl hydroxybenzoate and methylisothiazolinone
Mixture.
Mildy wash of the present invention is in addition to said components clearly require, in the range of lossless effect of the invention,
Other adjunct ingredients, such as pH adjusting agent, essence, pigment etc. can be added or used to, those skilled in the art can be according to routine
Standard selects common content.
The beneficial effects of the present invention are: the present invention provides a kind of anti-acne mildy wash, and the present invention is by adding mildly
Plant extraction ingredient cooperates basic material, anti-acne mildy wash is made, and can go deep into flesh bottom and remove skin spot, deep layer oil-control can adjust
The water and oil balance of skin is saved, small pox is removed, desalinates acne print, impaired skin is repaired, restores skin natural health state.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Examples 1 to 7
Examples 1 to 7 is the embodiment of anti-acne mildy wash of the present invention, and anti-acne mildy wash described in Examples 1 to 6 is matched
Fang Jianbiao 1.The formula of anti-acne mildy wash described in embodiment 7 is shown in Table 2.In Examples 1 to 7, the weight of each component in acne-removing composition A
Measure part are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, 3 parts of cloves alabastrum extract, 2 parts of radix scutellariae root extract, 2 parts of Angelica roots, sweet
1 part and 1 part of Gotu Kola P.E of grass roots extract;The parts by weight of each component in acne-removing composition B are as follows: herba hedyotis diffusae extract
1 part of 3 parts, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract.
The preparation method of anti-acne mildy wash described in Examples 1 to 7 the following steps are included:
S1, first will production pot clean up, sterilize it is spare;
S2, by lauric acid, myristic acid, palmitinic acid, stearic acid, behenyl behenate, glycerine myristate ester, PEG-
250 distearates, stearine, glycol distearate, Nipasol are added in main phase pot, are warming up to 75-80
DEG C, dissolution is complete;
S3, first by water be pumped into kettle in, dissolved potassium hydroxide is added, sequentially adds glycerol and EDETATE SODIUM, so
After be warming up to 75 DEG C, stir evenly;
S4, the material in step S3 is pumped into main phase pot, sodium methyl cocoyl taurate, lauroyl flesh is then added
Propylhomoserin sodium, Cocoamidopropyl betaine, heat preservation saponification 40 minutes;
S5, water, -4/ hydroxypropul starch copolymer of polyquaternium, glucan hydroxypropyl-trimethyl ammonium chloride is added, stirring is equal
It is even, start to be cooled to 36-38 DEG C or so, stops cooling, heat preservation continues to be slowly stirred 30 minutes, notice that speed cannot be fast, until
Pearly-lustre is precipitated completely, completely at cream, adds methylisothiazolinone, is stirred until homogeneous;
S6, it is eventually adding the essence dissolved, Melaleuca alternifolia leaf oil and menthol, be stirred until homogeneous, sampled to version
Verifying is discharged after qualified up to the anti-acne mildy wash.
The formula of anti-acne mildy wash described in 1 Examples 1 to 6 of table
Comparative example 1,2
Comparative example 1, the 2 anti-acne mildy wash formula be shown in Table 2.The parts by weight of each component in acne-removing composition B are as follows: white flower
1 part of 3 parts of HERBA HEDYOTIS DIFFUSAE extract, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract.Comparative example 1,2 anti-acne mildy wash
The preparation method is the same as that of Example 1~and 6.
2 embodiment 7 of table, comparative example 1, the 2 anti-acne mildy wash formula
Through examining Examples 1 to 7, comparative example 1,2 products to meet the pertinent regulations requirement of QB/T 1857-2004, sense organ refers to
Mark (color, fragrance, structure) meets industry regulation, and physical and chemical index (pH, heat-resisting, cold-resistant, active matter) meets industry regulation.
Embodiment 8
Product Safety evaluates (experiment of human skin patch)
One, trial target: the anti-acne mildy wash that Examples 1 to 7, comparative example 1,2 are prepared
Tested crowd's number: 90 people, women
Age: between 12~30 years old
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
Grouping: 9 groups, every group of 10 people, average age 25 ± 2 years old.
Two, patch method: selecting qualified spot tester, with closed patch experiment method, by tested material about 0.020g~
For 0.025g drop in spot tester, external application special adhesive tape is covered on subject back, and tested material is removed after 24 hours, after removing respectively
0.5, observation dermoreaction in 6,12,24,48 hours, records its knot according to dermoreaction grade scale in " cosmetics health specification "
Fruit.
Three, experimental result: human skin patch test result is shown: each group subject passes through Examples 1 to 9, comparative example
1, the patch test of the 2 anti-acne mildy wash, in observation dermoreaction in 0.5,6,12,24,48 hour, wherein 0 skin occurs
It is safe to illustrate that the anti-acne mildy wash uses for adverse reaction.
Embodiment 9
Fungistatic effect test
One, test material
1, test strain: propionibacterium acnes (ATCC6919).
2, test specimen: press S1, S2, S3, S4, S5, S6, S7, D1, D2 sample, 4 DEG C of storages are spare, wherein S1, S2, S3,
S4, S5, S6, S7, D1, D2 respectively correspond the proportion of Examples 1 to 7 and the anti-acne ingredient in comparative example 1,2.
3, culture medium: propionibacterium acnes culture medium, adjusting pH is 6.6~7.0.Agar wherein is added in solid medium
15g/L。
Two, test method
1, bacteria suspension preparation and inoculation: take freezing bacteria suspension 0.1mL in 5mL propionibacterium acnes fluid nutrient medium
In, in 37 DEG C of anaerobic condition culture 2d, to test bacteria suspension.
2, prepared by medical fluid: using normal saline dilution at experimental concentration respectively S1, S2, S3, S4, S5, S6, S7, D1, D2
0.1%, then gradient dilution respectively.For the first time test gradient dilution concentration be respectively 100% (sample stoste), 50%, 25%,
12.5%, 6.25%, 3.125%, 1.56%, 0.78%.Second test repetition measurement gradient dilution concentration is respectively 10%, 8%,
6%, 4%, 2%.
3, prepared by bacterium solution: diluting bacteria suspension with propionibacterium acnes fluid nutrient medium, makes its final bacteria concentration l06CFU/
mL。
4, culture and result interpretation: 100 μ L of bacterium solution and 100 μ L of medical fluid is added in micropore, while setting the feminine gender that bacterium is not added
The normal growth control of medical fluid is compareed and is not added, every kind of medicine does 3 in parallel, is averaged.It sets 37 DEG C of anaerobism to be incubated for, be seen after 48h
Examine result.Using muddiness is visually determined whether, data are read using direct method.As a result the premise judged is that growth control is good,
Blank control asepsis growth is clear, and other holes are increased with drug concentration gradient and the growth of bacterium is suppressed.
Table 3 first time antibacterial gradient test result
Concentration gradient | S1 | S2 | S3 | S4 | S5 | S6 | S7 | D1 | D2 |
100% | — | — | — | — | — | — | — | — | — |
50% | — | — | — | — | — | — | — | — | — |
25% | — | — | — | — | — | — | — | + | + |
12.5% | — | — | — | — | — | — | + | + | + |
6.25% | — | + | + | + | + | + | + | + | + |
3.125% | + | + | + | + | + | + | + | + | + |
1.56% | + | + | + | + | + | + | + | + | + |
0.78% | + | + | + | + | + | + | + | + | + |
Note: wherein "+" representative has bacterium growth, and "-" represents nothing.
Second of table 4 antibacterial gradient test result
Concentration gradient | S1 | S2 | S3 | S4 | S5 | S6 | S7 | D1 | D2 |
10% | — | — | — | — | — | — | + | + | + |
8% | — | — | — | + | + | + | + | + | + |
6% | — | + | + | + | + | + | + | + | + |
4% | + | + | + | + | + | + | + | + | + |
2% | + | + | + | + | + | + | + | + | + |
1% | + | + | + | + | + | + | + | + | + |
Note: wherein "+" representative has bacterium growth, and "-" represents nothing.
5, result
From 3 result of table as it can be seen that 0.1% solution of Examples 1 to 6,12.5% concentration or more is diluted at it, it is right
Propionibacterium acnes have a good inhibiting effect, and embodiment 7 in 25% dilution or more can be only achieved effect, comparative example 1,
It is more than 2 50% concentration of needs.From 4 result of table as it can be seen that the Mlc of Examples 1 to 6 can reach in 10% dilution, implement
The Mlc of example 1 can reach fungistatic effect in 6% diluted concentration.From the above results, anti-acne ingredient of the present invention is most
Low addition about 0.01% can basically reach the effect for inhibiting propionibacterium acnes, and anti-acne ingredient of the present invention is used and dispelled
When acne composition A and acne-removing composition B are used in conjunction with, there is stronger fungistatic effect when than being used alone.
Embodiment 10
Clinical test is carried out to Examples 1 to 7 and comparative example 1,2 mildy wash, specific as follows:
Number: 90 people are divided into 9 groups, every group of 10 people, male to female ratio 1:1, and face has acne
Time: 21 days
Position: face
Sample: mildy wash described in Examples 1 to 7 and comparative example 1, comparative example 2
Evaluation: (photo is not shown) is evaluated and is taken pictures in progress according to GAGS point-score:
GAGS point-score is Doshi etc. the 1997 acne comprehensive classification system Global Acne Grading proposed
System (GAGS) is a kind of scoring method, has the characteristics that accurate, consistency is strong, quick and overall assessment effect is good.Specifically
Are as follows: according to the density of pilosebaceous unit, distribution and approximate area, acne predilection site is divided into 6 areas: Ith area, forehead, II
Area: right cheek, IIIth area: left cheek, IVth area: nose, V area Xia Ke of area, VIth area: chest and upper back.Ith area, IIth area, III area's factor score value
It is 2, IVth area, V area's factor score value are 1, and VI area's factor score value is 3, and each region skin lesion score value is that (principle is local most serious
Skin lesion determine the score value in the area): 0=is without skin lesion;1 >=1 acne;2 >=1 papules;3 >=1 running sores;4 >=1 tubercles.
Area's total score=factor score value × skin lesion score value, the sum of variant dermatotome total score are comprehensive scores.
Evaluation result is shown in Table 5.
5 Examples 1 to 7 of table and comparative example 1, the GAGS score evaluation result of 2 mildy wash
Group | Before use | 3 days | 7 days | 14 days | 21 days |
Embodiment 1 | 18.0 | 15.3 | 14.0* | 11.8** | 10.8** |
Embodiment 2 | 18.6 | 16.9 | 15.5* | 14.2** | 13.2** |
Embodiment 3 | 18.8 | 16.8 | 15.3* | 14.5** | 13.5** |
Embodiment 4 | 18.5 | 16.3 | 15.2* | 13.8** | 12.8** |
Embodiment 5 | 18.6 | 17.0 | 15.1* | 14.5** | 13.0** |
Embodiment 6 | 17.6 | 15.9 | 14.8* | 14.1** | 13.0** |
Embodiment 7 | 17.8 | 16.6 | 15.5* | 14.9** | 14.1** |
Comparative example 1 | 18.2 | 17.0 | 16.2 | 15.8* | 15.0** |
Comparative example 2 | 18.0 | 17.5 | 17.0 | 16.6 | 16.1 |
* P < 0.05VS is before use, before * * P < 0.01VS use
From table 3 it can be seen that with use it is preceding compared with, acne score value is substantially reduced after mildy wash 7 days described in Examples 1 to 7
(P < 0.05) is significantly reduced when using 14 and 21 days.As can be seen from the table, compared with Example 1, embodiment 4~6
Comprehensive scores after using 21 days are higher, illustrate that acne-removing composition A and B need the competence exertion under certain proportion preferably to dispel
Acne effect;Compared with Example 1, the anti-acne effect of embodiment 7 and comparative example 1,2 is worse, illustrates acne-removing composition A and anti-acne group
It closes object B and is used cooperatively better effect, compared with embodiment 4~6, the anti-acne effect of mildy wash described in embodiment 1 is more preferably.
Embodiment 11
Product effect assessment
One, trial target: anti-acne mildy wash prepared by Examples 1 to 3
Two, tested crowd
Gender number: 90 people, men and women is than being about 1:1
Age: between 12~30 years old
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
Grouping: being divided into 3 groups, every group of 30 people, and average age 25 ± 2 years old.
Three, test method: respectively using anti-acne mildy wash prepared by Examples 1 to 3, observe and experience using effect.
Application method: it after subject cleans face, takes suitable anti-acne mildy wash to be uniformly applied to face, is massaged into absorption.Often
Day sooner or later respectively using primary, adhere to using one month, at least check weekly once to understand whether there is or not whole body and local adverse reaction,
And result is recorded in detail.
Test assessment result is shown in Table 6~8.
6 embodiment of table, 1 anti-acne mildy wash tries out (one month) feedback conclusive table
7 embodiment of table, 2 anti-acne mildy wash tries out (one month) feedback conclusive table
8 embodiment of table, 3 anti-acne mildy wash tries out (one month) feedback conclusive table
By table 6~8 it is found that the anti-acne mildy wash of the embodiment of the present invention 1~3 liking and approving by subject, tested
Person indicates that anti-acne mildy wash of the present invention is gentle, and can restrain pore, skin of releiving, and adjusts skin water and oil balance, deep
Layer is repaired, improves small pox skin.With the degree of recognition highest of 1 anti-acne mildy wash of embodiment in Examples 1 to 3.It is all tested simultaneously
There is allergic phenomena in non-someone in person, does not also occur the situations such as pruitus, shouting pain, redness.Therefore, anti-acne face cleaning of the present invention
Newborn mild safety, can be used for a long time.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of anti-acne mildy wash, which is characterized in that include acne-removing composition A;The acne-removing composition A is extracted comprising red sage root
Object, cloves alabastrum extract, radix scutellariae root extract, Angelica roots, licorice root extract and Gotu Kola P.E.
2. anti-acne mildy wash as described in claim 1, which is characterized in that the parts by weight of each component in the acne-removing composition A are as follows:
10~20 parts of Radix Salviae Miltiorrhizae root extract, 2~4 parts of cloves alabastrum extract, 1~3 part of radix scutellariae root extract, Angelica roots 1~3
Part, 0.5~2 part of licorice root extract and 0.5~2 part of Gotu Kola P.E;Preferably, each component in the acne-removing composition A
Parts by weight are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, 3 parts of cloves alabastrum extract, 2 parts of radix scutellariae root extract, Angelica roots 2
Part, 1 part of licorice root extract and 1 part of Gotu Kola P.E.
3. anti-acne mildy wash as claimed in claim 2, which is characterized in that the acne-removing composition A is in the anti-acne mildy wash
Weight percentage be 0.4~0.6%.
4. anti-acne mildy wash as described in claim 1, which is characterized in that the mildy wash also includes acne-removing composition B;It is described to dispel
Acne composition B includes herba hedyotis diffusae extract, honeysuckle extract and fruitlet Chinese honey locust seed extract.
5. anti-acne mildy wash as claimed in claim 4, which is characterized in that the parts by weight of each component in the acne-removing composition B are as follows:
0.5~2 part of 2~4 parts of herba hedyotis diffusae extract, 2~4 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract;Preferably, described
The parts by weight of each component in acne-removing composition B are as follows: 3 parts of herba hedyotis diffusae extract, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed mention
Take 1 part of object.
6. anti-acne mildy wash as claimed in claim 5, which is characterized in that the acne-removing composition B is in the anti-acne mildy wash
Weight percentage be 0.4~0.6%.
7. anti-acne mildy wash as described in claim 1, which is characterized in that the mildy wash also includes surfactant;The table
Face activating agent includes sodium methyl cocoyl taurate, sodium lauroyl sarcosine, Cocoamidopropyl betaine, polyquaternium-
4/ hydroxypropul starch copolymer and glucan hydroxypropyl-trimethyl ammonium chloride;Each ingredient of surfactant is in the mildy wash
In weight percentage are as follows: sodium methyl cocoyl taurate 4~6%, sodium lauroyl sarcosine 1.6~2.4%, cocounut oil acyl
Amine propyl betaine 1.5~2%, -4/ hydroxypropul starch copolymer 0.05~0.1% of polyquaternium and glucan hydroxypropyl trimethylammonium
Ammonium chloride 0.05~0.1%.
8. anti-acne mildy wash as described in claim 1, which is characterized in that the mildy wash also includes skin-active ingredient and emollient;
The skin-active ingredient includes menthol;Weight percentage of the menthol in the mildy wash is 0.04~0.06%;
The emollient includes myristic acid, stearic acid, palmitinic acid, lauric acid and stearine;Each ingredient of emollient exists
Weight percentage in the mildy wash are as follows: myristic acid 10~14%, stearic acid 8~12%, palmitinic acid 4~6%, laurel
Acid 2.5~3.5% and stearine 0.5~1%.
9. anti-acne mildy wash as described in claim 1, which is characterized in that the mildy wash also includes moisturizer and emulsifier;Institute
Stating moisturizer includes glycerol;The emulsifier includes behenyl behenate, glycerine myristate ester and PEG-250 distearyl acid
Ester.
10. anti-acne mildy wash as claimed in claim 4, which is characterized in that the mildy wash includes following weight percentage
Component: acne-removing composition A 0.4~0.6%, acne-removing composition B 0.4~0.6%, sodium methyl cocoyl taurate 4~
6%, sodium lauroyl sarcosine 1.6~2.4%, Cocoamidopropyl betaine 1.5~2%, -4/ hydroxypropul starch of polyquaternium
Copolymer 0.05~0.1%, glucan hydroxypropyl-trimethyl ammonium chloride 0.05~0.1%, menthol 0.04~0.06%, glycerol
13~17%, myristic acid 10~14%, stearic acid 8~12%, palmitinic acid 4~6%, lauric acid 2.5~3.5%, glycerol are hard
Resin acid ester 0.5~1%, behenyl behenate 1.2~1.8%, glycerine myristate ester 0.5~1.4%, PEG-250 bis- are hard
Resin acid ester 0.4~0.8%;Preferably, the mildy wash includes the component of following weight percentage: acne-removing composition A
0.5%, acne-removing composition B 0.5%, sodium methyl cocoyl taurate 5%, sodium lauroyl sarcosine 2%, coconut oleoyl amine third
Base glycine betaine 1.8%, -4/ hydroxypropul starch copolymer 0.08% of polyquaternium, glucan hydroxypropyl-trimethyl ammonium chloride
0.08%, menthol 0.05%, glycerol 15%, myristic acid 12%, stearic acid 10%, palmitinic acid 5%, lauric acid 3%, glycerol
Stearate 0.8%, behenyl behenate 1.5%, glycerine myristate ester 0.9%, PEG-250 distearate 0.6%.
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CN109806202A (en) * | 2019-04-01 | 2019-05-28 | 贵州阿斯科科技开发有限公司 | A kind of Chinese herbal medicine anti-acne facial cleanser and preparation method thereof |
CN110585349A (en) * | 2019-09-30 | 2019-12-20 | 广东密尚生物科技有限公司 | Acne-removing and bacterium-inhibiting composition and preparation method and application thereof |
CN110652486A (en) * | 2019-11-12 | 2020-01-07 | 江苏逸洁生物科技股份有限公司 | Medicinal acne-removing gel |
CN110721139A (en) * | 2019-10-30 | 2020-01-24 | 广东密尚生物科技有限公司 | Oil-controlling acne-removing composition and preparation method and application thereof |
CN111658578A (en) * | 2020-07-29 | 2020-09-15 | 雷菁 | Oil-control acne-removing facial cleanser and production method thereof |
WO2021262536A1 (en) * | 2020-06-23 | 2021-12-30 | Rohm And Haas Company | Method of making and using a skin moisturizing formulation |
CN114762667A (en) * | 2021-01-14 | 2022-07-19 | 江西初芙化妆品有限公司 | Acne-removing facial cleanser and preparation method thereof |
CN114762671A (en) * | 2021-01-14 | 2022-07-19 | 江西初芙化妆品有限公司 | Oil-control cleansing cream and preparation method thereof |
CN114796063A (en) * | 2022-06-02 | 2022-07-29 | 广州一一生物技术有限公司 | Mild and antibacterial facial cleanser and application thereof |
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CN109806202A (en) * | 2019-04-01 | 2019-05-28 | 贵州阿斯科科技开发有限公司 | A kind of Chinese herbal medicine anti-acne facial cleanser and preparation method thereof |
CN110585349A (en) * | 2019-09-30 | 2019-12-20 | 广东密尚生物科技有限公司 | Acne-removing and bacterium-inhibiting composition and preparation method and application thereof |
CN110721139A (en) * | 2019-10-30 | 2020-01-24 | 广东密尚生物科技有限公司 | Oil-controlling acne-removing composition and preparation method and application thereof |
CN110652486A (en) * | 2019-11-12 | 2020-01-07 | 江苏逸洁生物科技股份有限公司 | Medicinal acne-removing gel |
WO2021262536A1 (en) * | 2020-06-23 | 2021-12-30 | Rohm And Haas Company | Method of making and using a skin moisturizing formulation |
CN111658578A (en) * | 2020-07-29 | 2020-09-15 | 雷菁 | Oil-control acne-removing facial cleanser and production method thereof |
CN114762667A (en) * | 2021-01-14 | 2022-07-19 | 江西初芙化妆品有限公司 | Acne-removing facial cleanser and preparation method thereof |
CN114762671A (en) * | 2021-01-14 | 2022-07-19 | 江西初芙化妆品有限公司 | Oil-control cleansing cream and preparation method thereof |
CN114796063A (en) * | 2022-06-02 | 2022-07-29 | 广州一一生物技术有限公司 | Mild and antibacterial facial cleanser and application thereof |
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