CN109157450A - A kind of anti-acne essence cream - Google Patents

A kind of anti-acne essence cream Download PDF

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Publication number
CN109157450A
CN109157450A CN201811207346.3A CN201811207346A CN109157450A CN 109157450 A CN109157450 A CN 109157450A CN 201811207346 A CN201811207346 A CN 201811207346A CN 109157450 A CN109157450 A CN 109157450A
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China
Prior art keywords
acne
extract
essence cream
removing composition
parts
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CN201811207346.3A
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CN109157450B (en
Inventor
何志青
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Guangzhou Kema Biotechnology Polytron Technologies Inc
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Guangzhou Kema Biotechnology Polytron Technologies Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

Abstract

The invention discloses a kind of anti-acne essence creams, include acne-removing composition A;The acne-removing composition A includes Radix Salviae Miltiorrhizae root extract, cloves alabastrum extract, radix scutellariae root extract, Angelica roots, licorice root extract and Gotu Kola P.E.The present invention cooperates basic material, anti-acne essence cream is made, is adjustable the water and oil balance of skin, removes small pox, desalinate acne print, repairs impaired skin, restores skin natural health state by adding mild plant extraction ingredient.

Description

A kind of anti-acne essence cream
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of anti-acne essence cream.
Background technique
With the development of economy with the continuous improvement of quality of life, the anti-acne of Chinese whelk patient is realized to be improved year by year. Chinese skin disease association, the joint investigation of adolescents in China federation are the results show that the disease incidence of China's whelk is in rise year by year The problem of trend, 80% or more young people encountered whelk to some extent, the state of an illness it is more serious account for the 1/3 of young people with On.
Acne is being commonly called as acne, is called " whelk ", " dark sore " or " acne ", is due to hair follicle and sebum adenemphraxis, hair A kind of skin disease that inflammation is caused.When puberty, intracorporal hormone can stimulate hair growth, promote smegma more heavy wool Therefore rouge, hair and sebaceous glands accumulate many substances, since this symptom is common in youth of both sexes, so just it is referred to as " the youth Acne ".
Whelk is a kind of common chronic dermatosis, and juvenile onset number highest is mainly in face and chest and back, table It is now the various skin injuries such as blackhead, papule, running sore, tubercle, tumour and scar, hinders appearance.The main reason of green whelk It is that the clogging of pores as caused by the accumulation of sebum causes sebum to accumulate the acne to be formed, once infection occur will be very short Appearance deterioration forms serious tumour in time or this is abscess.
Acne itself is not fearful, and maximum harm is not in time or acne print, acne hole, acne are easily left in irregular treatment Scar seriously affects image.Acne hole acne scar be really inflammation invasion plus with hand squeeze the equivalent damage epidermis of skin, skin corium with And the subcutaneous tissue of more lower section, cause the generation of the destruction of skin, the defect of tissue and scar.These problems not only serious shadow Appearance is rung, is also acquired a certain degree of difficulty in the treatment.
So for small pox crowd, in order to completely remove small pox acne print, in addition to paying attention to diet, living habit, A safely and effectively product for resolving poxes is essential.
Summary of the invention
A kind of anti-acne essence cream is provided it is an object of the invention to overcome the shortcomings of the prior art place.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of anti-acne essence cream includes acne-removing composition A; Weight percentage of the acne-removing composition A in the anti-acne essence cream is 0.4~0.6%;The acne-removing composition A packet Root extract containing Radix Salviae Miltiorrhizae, cloves alabastrum extract, radix scutellariae root extract, Angelica roots, licorice root extract and centella Extract.
The technical scheme adopted by the invention is as follows: a kind of anti-acne essence cream, includes acne-removing composition A;The acne-removing composition A Weight percentage in the anti-acne essence cream is 0.4~0.6%;The acne-removing composition A include Radix Salviae Miltiorrhizae root extract, Cloves alabastrum extract, radix scutellariae root extract, Angelica roots, licorice root extract and Gotu Kola P.E.
The present invention uses above-mentioned acne-removing composition A, and Radix Salviae Miltiorrhizae root extract has effects that antibacterial, oil-control, anti-inflammatory, angelica root Extract has the effect of activating microcirculation and removing stasis medicinal, improves follicular keratosis, and licorice root extract and Gotu Kola P.E have reconciliation, repair The effect of, and cloves alabastrum extract and radix scutellariae root extract can promote Radix Salviae Miltiorrhizae root extract, Angelica roots, licorice The Transdermal absorption of extract and Gotu Kola P.E etc. dredges pore, to realize " safely, effectively " anti-acne.Acne-removing composition A It has the following characteristics that and 1) inhibits 5α-reductase activity, balance sebum secretion;2) inhibit acne correlation pathogen in hair follicle sebum All living creatures is long, inhibiting bacteria and diminishing inflammation;3) good suppression acne activity, skin acne state caused by improving because of cosmetics;4) by promoting to inhale thoroughly It receives, dredging pore, improve three kinds of approach collaboration promotion acne-removings of follicular keratosis.
The acne-removing composition A can realize the effect of its anti-acne in essence cream using above-mentioned additive amount, reach efficient benefit Purpose.
Preferably, in the acne-removing composition A each component parts by weight are as follows: 10~20 parts of Radix Salviae Miltiorrhizae root extract, lilac 2~4 parts of flower bud extract, 1~3 part of radix scutellariae root extract, 1~3 part of Angelica roots, 0.5~2 part of licorice root extract and product Avenge careless 0.5~2 part of extract.
It is highly preferred that in the acne-removing composition A each component parts by weight are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, cloves bud 3 parts of extract, 2 parts of radix scutellariae root extract, 2 parts of Angelica roots, 1 part of licorice root extract and 1 part of Gotu Kola P.E.Respectively When its extract uses said ratio, each extract can be made to give full play to respective effect.
Preferably, the essence cream also includes acne-removing composition B;The acne-removing composition B is in the anti-acne essence cream Weight percentage be 0.4~0.6%;The acne-removing composition B includes herba hedyotis diffusae extract, honeysuckle extract and small Fruit Chinese honey locust seed extract.
Herba hedyotis diffusae extract has anti-inflammatory and antibacterial action, all has different degrees of antibacterial to coccus and bacillus and kills Bacterium effect;Caulis lonicerae has antibacterial and antiinflammation, has apparent Antibacterial Activity to S. aureus L-forms and propionibacterium acnes.Institute Each extract cooperation of acne-removing composition B is stated, there is significant inhibiting effect to 5α-reductase, acne symptom can be mitigated, desalinate Acne print, while having effects that oil-control.Acne-removing composition B and acne-removing composition A cooperate jointly, can effectively mitigate small pox, help thin Born of the same parents live again, and repair impaired cell tissue, and activation fibr tissue is rebuild, and it is smoothly fine and smooth to go back skin, smooth it is coarse, keep the skin wet and Nutrition enables skin softness, water moisten, is flexible, realizes that small pox is eliminated completely.And the acne-removing composition B in essence cream using upper Stating additive amount can realize that it desalinates the effect of acne print, realize the efficient utilization of acne-removing composition B.
Preferably, in the acne-removing composition B each component parts by weight are as follows: 2~4 parts of herba hedyotis diffusae extract, honeysuckle 0.5~2 part of 2~4 parts of extract and fruitlet Chinese honey locust seed extract.When its each extract uses said ratio, each extraction can be made Object gives full play to respective effect.
It is highly preferred that in the acne-removing composition B each component parts by weight are as follows: 3 parts of herba hedyotis diffusae extract, honeysuckle mention Take 1 part of 3 parts of object and fruitlet Chinese honey locust seed extract.
Preferably, the essence cream also includes Fructus psidii guajavae immaturus extract 1~2% and cork tree extract 0.012~0.02%. The effect of Fructus psidii guajavae immaturus extract and cork tree extract all have antiphlogistic antibacterial, using above-mentioned additive amount and acne-removing composition A and Acne-removing composition B cooperates jointly plays its effect.
Preferably, the essence cream also includes skin-active ingredient;The skin-active ingredient includes niacinamide;The niacinamide is in institute Stating the weight percentage in essence cream is 1.6~2.4%.
Above-mentioned skin-active ingredient can infiltrate thoroughly cuticula with Cucumber Extract, and skin is promoted to combine acne-removing composition A, anti-acne The absorption of the plant extracts such as object B, Fructus psidii guajavae immaturus extract and cork tree extract, improves hair follicle keratinization, can more have Imitate antibacterial, anti-inflammatory and oil-control.
Preferably, the essence cream also includes moisturizer;The moisturizer include glycerol, Natrulon H-10, ethoxy urea, Trehalose and propylene glycol;In the essence cream, the weight percentage of each ingredient of moisturizer are as follows: glycerol 2.5~3.5% gathers Glycerol -10 1.6~2.4%, ethoxy urea 0.7~1.3%, trehalose 0.4~0.6% and propylene glycol 0.14~0.2%.
Preferably, the essence cream also includes emollient, emulsifier and thickener;The emollient includes that myristic acid is different Propyl ester, cetostearyl alcohol, dimethyl silicone polymer and ethylhexyl palmitate;The emulsifier include stearine, PEG-100 stearate and PEG-20 stearate;The thickener includes carbomer.
Preferably, the essence cream includes the component of following weight percentage: acne-removing composition A0.4~0.6% is dispelled Acne composition B 0.4~0.6%, Fructus psidii guajavae immaturus extract 1~2%, cork tree extract 0.012~0.02%, niacinamide 1.5~ 2.4%, menthol 0.016~0.025%, camphor 0.008~0.013%, borneol 0.007~0.012%, propylene glycol 1.8~ 2.8%, glycerol 0.8~1.2%, Cremophor RH40 0.4~0.5%, carbomer 0.15~0.25%, hydroxy ethyl fiber Element 0.04~0.06% and EDETATE SODIUM 0.04~0.06%.Have the water oil for adjusting skin flat using the essence cream of said ratio Weighing apparatus, the effect of anti-inflammatory and desalination acne print.
It is highly preferred that the essence cream includes the component of following weight percentage: acne-removing composition A0.5%, anti-acne group Close object B 0.5%, Fructus psidii guajavae immaturus extract 2.5%, cork tree extract 0.025%, niacinamide 2%, menthol 0.02%, camphor 0.01%, borneol 0.01%, propylene glycol 2.21%, glycerol 1%, Cremophor RH40 0.45%, carbomer 0.2%, hydroxyl Ethyl cellulose 0.05% and EDETATE SODIUM 0.05%.It is best using the essence cream anti-acne effect of above-mentioned formula.
Preferably, the essence cream further includes preservative;The preservative is methyl hydroxybenzoate, Nipasol, bis- (hydroxyl first Base) imidazolidinyl urea and iodine propilolic alcohol butyl mephenesin Carbamate mixture.
Essence cream of the present invention is in addition to said components clearly require, in the range of lossless effect of the invention, Other adjunct ingredients, such as pH adjusting agent, essence, pigment etc. can be added or used to, those skilled in the art can be according to routine Standard selects common content.
The beneficial effects of the present invention are: the present invention provides a kind of anti-acne essence creams, and the present invention is by adding mildly Plant extraction ingredient cooperates basic material, and anti-acne essence cream is made, is adjustable the water and oil balance of skin, removes small pox, desalinate acne Print repairs impaired skin, restores skin natural health state.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention It is described further.
Examples 1 to 10
Examples 1 to 10 is the embodiment of anti-acne essence cream of the present invention, anti-acne essence cream described in Examples 1 to 6 Formula is shown in Table 1.The formula of the anti-acne essence cream of embodiment 7~10 is shown in Table 2.It is each in acne-removing composition A in Examples 1 to 10 The parts by weight of component are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, 3 parts of cloves alabastrum extract, 2 parts of radix scutellariae root extract, angelica root extract 2 parts of object, 1 part of licorice root extract and 1 part of Gotu Kola P.E;The parts by weight of each component in acne-removing composition B are as follows: oldenlandia 1 part of 3 parts of careless extract, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract.
The preparation method of anti-acne essence cream described in Examples 1 to 10 the following steps are included:
S1, by carbomer and water with hanging homogenizer homogeneous to no particle that is uniformly dispersed, it is spare;
The uniform carbomer of homogenous disperse in S2, Jiang Shui, glycerol, Natrulon H-10, ethoxy urea, trehalose and step S1 It is added in main phase pot with water, is heated with stirring to 85 DEG C, keep the temperature 20 minutes;
S3, by stearine, PEG-100 stearate, cetostearyl alcohol, PEG-20 stearate, myristic acid Isopropyl ester, dimethyl silicone polymer, ethylhexyl palmitate, methyl hydroxybenzoate and Nipasol are added in oily phase pot, are heated to 80 DEG C, stirring is to being completely dissolved;
S4, it vacuumizes, opens homogeneous, the material in step S3 is pumped into main cooker, homogeneous 5 minutes, heat preservation is after ten minutes Start to cool down;
S5, when being down to 50 DEG C, triethanolamine and Fructus psidii guajavae immaturus extract, cork tree extract, niacinamide, bis- (hydroxyl first is added Base) imidazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, propylene glycol and Melaleuca alternifolia leaf oil, it is stirred until homogeneous, drops to often Temperature is discharged after the assay was approved up to the anti-acne essence cream.
The formula of anti-acne essence cream described in 1 Examples 1 to 6 of table
Comparative example 1,2
Comparative example 1, the 2 anti-acne essence creams formula be shown in Table 2.The parts by weight of each component in acne-removing composition B are as follows: white flower 1 part of 3 parts of HERBA HEDYOTIS DIFFUSAE extract, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract.Comparative example 1,2 anti-acne essence creams The preparation method is the same as that of Example 1~and 6.
2 embodiment 7~10 of table, comparative example 1, the 2 anti-acne essence creams formula
Through examining Examples 1 to 10, comparative example 1,2 products to meet the pertinent regulations requirement of QB/T 1857-2004, sense organ Index (color, fragrance, structure) meets industry regulation, and physical and chemical index (pH, heat-resisting, cold-resistant, active matter) meets industry regulation.
Embodiment 11
Product Safety evaluates (experiment of human skin patch)
One, trial target: the anti-acne essence cream that Examples 1 to 10, comparative example 1,2 are prepared
Tested crowd's number: 120 people, women
Age: between 12~30 years old
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
Grouping: 12 groups, every group of 10 people, average age 25 ± 2 years old.
Two, patch method: selecting qualified spot tester, with closed patch experiment method, by tested material about 0.020g~ For 0.025g drop in spot tester, external application special adhesive tape is covered on subject back, and tested material is removed after 24 hours, after removing respectively 0.5, observation dermoreaction in 6,12,24,48 hours, records its knot according to dermoreaction grade scale in " cosmetics health specification " Fruit.
Three, experimental result: human skin patch test result is shown: each group subject passes through Examples 1 to 10, comparative example 1, the patch test of the 2 anti-acne essence creams, in observation dermoreaction in 0.5,6,12,24,48 hour, wherein 0 skin occurs It is safe to illustrate that the anti-acne essence cream uses for adverse reaction.
Embodiment 12
Fungistatic effect test
One, test material
1, test strain: propionibacterium acnes (ATCC6919).
2, test specimen: press S1, S2, S3, S4, S5, S6, S7, S8, S9, D1, D2 sample, 4 DEG C of storages are spare, wherein S1, S2, S3, S4, S5, S6, S7, S8, S9, D1, D2 respectively correspond the proportion of Examples 1 to 9 and the anti-acne ingredient in comparative example 1,2.
3, culture medium: propionibacterium acnes culture medium, adjusting pH is 6.6~7.0.Agar wherein is added in solid medium 15g/L。
Two, test method
1, bacteria suspension preparation and inoculation: take freezing bacteria suspension 0.1mL in 5mL propionibacterium acnes fluid nutrient medium In, in 37 DEG C of anaerobic condition culture 2d, to test bacteria suspension.
2, prepared by medical fluid: using normal saline dilution at test respectively S1, S2, S3, S4, S5, S6, S7, S8, S9, D1, D2 Concentration 0.1%, then gradient dilution respectively.For the first time test gradient dilution concentration be respectively 100% (sample stoste), 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%.Test repetition measurement gradient dilution concentration is respectively for the second time 10%, 8%, 6%, 4%, 2%.
3, prepared by bacterium solution: diluting bacteria suspension with propionibacterium acnes fluid nutrient medium, makes its final bacteria concentration l06CFU/ mL。
4, culture and result interpretation: 100 μ L of bacterium solution and 100 μ L of medical fluid is added in micropore, while setting the feminine gender that bacterium is not added The normal growth control of medical fluid is compareed and is not added, every kind of medicine does 3 in parallel, is averaged.It sets 37 DEG C of anaerobism to be incubated for, be seen after 48h Examine result.Using muddiness is visually determined whether, data are read using direct method.As a result the premise judged is that growth control is good, Blank control asepsis growth is clear, and other holes are increased with drug concentration gradient and the growth of bacterium is suppressed.
Table 3 first time antibacterial gradient test result
Note: wherein "+" representative has bacterium growth, and "-" represents nothing.
Second of table 4 antibacterial gradient test result
Note: wherein "+" representative has bacterium growth, and "-" represents nothing.
5, test result
From 3 result of table as it can be seen that 0.1% solution of Examples 1 to 6,12.5% concentration or more is diluted at it, it is right Propionibacterium acnes have a good inhibiting effect, and embodiment 7~9 can be only achieved effect in 25% dilution or more, compare It is more than 1,2 50% concentration of needs of example.From 4 result of table as it can be seen that the Mlc of Examples 1 to 6 can reach in 10% dilution, The Mlc of embodiment 1 can reach fungistatic effect in 6% diluted concentration.From the above results, anti-acne of the present invention at Divide minimum addition about 0.01%, the effect for inhibiting propionibacterium acnes can be basically reached, and anti-acne ingredient of the present invention is adopted When being used in conjunction with acne-removing composition A, acne-removing composition B, Fructus psidii guajavae immaturus extract and cork tree extract, than using one of which Or there is stronger fungistatic effect when two kinds of uses.
Embodiment 13
Clinical test is carried out to Examples 1 to 10 and comparative example 1, the 2 essence creams, specific as follows:
Number: 120 people are divided into 12 groups, every group of 10 people, male to female ratio 1:1, and face has acne
Time: 21 days
Position: face
Sample: the cream of essence described in Examples 1 to 10 and comparative example 1, comparative example 2
Evaluation: (photo is not shown) is evaluated and is taken pictures in progress according to GAGS point-score:
GAGS point-score is Doshi etc. the 1997 acne comprehensive classification system Global AcneGrading proposed System (GAGS) is a kind of scoring method, has the characteristics that accurate, consistency is strong, quick and overall assessment effect is good.Specifically Are as follows: according to the density of pilosebaceous unit, distribution and approximate area, acne predilection site is divided into 6 areas: Ith area, forehead, II Area: right cheek, IIIth area: left cheek, IVth area: nose, V area Xia Ke of area, VIth area: chest and upper back.Ith area, IIth area, III area's factor score value It is 2, IVth area, V area's factor score value are 1, and VI area's factor score value is 3, and each region skin lesion score value is that (principle is local most serious Skin lesion determine the score value in the area): 0=is without skin lesion;1 >=1 acne;2 >=1 papules;3 >=1 running sores;4 >=1 tubercles. Area's total score=factor score value × skin lesion score value, the sum of variant dermatotome total score are comprehensive scores.
Evaluation result is shown in Table 5.
5 Examples 1 to 10 of table and comparative example 1, the GAGS score evaluation result of the 2 essence creams
* P < 0.05VS is before use, before * * P < 0.01VS use
From table 3 it can be seen that with use it is preceding compared with, essence described in Examples 1 to 10 cream 3 days after acne score value be substantially reduced (P < 0.05) is significantly reduced when using 7,14 and 21 days, and statistically significant (P < 0.01).As can be seen from the table, Compared with Example 1, the comprehensive scores after using 21 days of embodiment 4~6 are higher, illustrate that acne-removing composition A and B need It is certain to match the lower better anti-acne effect of competence exertion;Compared with Example 1, the anti-acne of embodiment 7~9 and comparative example 1,2 is imitated Fruit is worse, illustrates acne-removing composition A, acne-removing composition B, Fructus psidii guajavae immaturus extract and cork tree extract with the use of anti-acne effect More preferably, the anti-acne effect of embodiment 10 is worse than embodiment 1, illustrates that niacinamide plays certain auxiliary anti-acne effect.
Embodiment 14
Product effect assessment
One, trial target: the cream of anti-acne essence prepared by Examples 1 to 3
Two, tested crowd
Gender number: 90 people, men and women is than being about 1:1
Age: between 12~30 years old
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
Grouping: being divided into 3 groups, every group of 30 people, and average age 25 ± 2 years old.
Three, test method: respectively using anti-acne essence cream prepared by Examples 1 to 3, observe and experience using effect. Application method: it after subject cleans face, takes suitable anti-acne essence cream to be uniformly applied to face, is massaged into absorption.Often Day sooner or later respectively using primary, adhere to using one month, at least check weekly once to understand whether there is or not whole body and local adverse reaction, And result is recorded in detail.
Test assessment result is shown in Table 6~8.
6 embodiment of table, 1 anti-acne essence cream tries out (one month) feedback conclusive table
7 embodiment of table, 2 anti-acne essence cream tries out (one month) feedback conclusive table
8 embodiment of table, 3 anti-acne essence cream tries out (one month) feedback conclusive table
By table 6~8 it is found that the anti-acne essence cream of the embodiment of the present invention 1~3 liking and approving by subject, tested Person indicates that anti-acne essence cream of the present invention is gentle, and can restrain pore, skin of releiving, and adjusts skin water and oil balance, deep Layer is repaired, improves small pox skin.With the degree of recognition highest of 1 anti-acne essence cream of embodiment in Examples 1 to 3.It is all tested simultaneously There is allergic phenomena in non-someone in person, does not also occur the situations such as pruitus, shouting pain, redness.Therefore, anti-acne essence of the present invention Newborn mild safety, can be used for a long time.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention And range.

Claims (10)

1. a kind of anti-acne essence cream, which is characterized in that include acne-removing composition A;The acne-removing composition A is in the anti-acne essence Weight percentage in cream is 0.4~0.6%;The acne-removing composition A includes Radix Salviae Miltiorrhizae root extract, the extraction of cloves bud Object, radix scutellariae root extract, Angelica roots, licorice root extract and Gotu Kola P.E.
2. anti-acne essence cream as described in claim 1, which is characterized in that the parts by weight of each component in the acne-removing composition A are as follows: 10~20 parts of Radix Salviae Miltiorrhizae root extract, 2~4 parts of cloves alabastrum extract, 1~3 part of radix scutellariae root extract, Angelica roots 1~3 Part, 0.5~2 part of licorice root extract and 0.5~2 part of Gotu Kola P.E;Preferably, each component in the acne-removing composition A Parts by weight are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, 3 parts of cloves alabastrum extract, 2 parts of radix scutellariae root extract, Angelica roots 2 Part, 1 part of licorice root extract and 1 part of Gotu Kola P.E.
3. anti-acne essence cream as described in claim 1, which is characterized in that the essence cream also includes acne-removing composition B;It is described to dispel Weight percentage of the acne composition B in the anti-acne essence cream is 0.4~0.6%;The acne-removing composition B includes white flower HERBA HEDYOTIS DIFFUSAE extract, honeysuckle extract and fruitlet Chinese honey locust seed extract.
4. anti-acne essence cream as claimed in claim 3, which is characterized in that the parts by weight of each component in the acne-removing composition B are as follows: 0.5~2 part of 2~4 parts of herba hedyotis diffusae extract, 2~4 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract;Preferably, described The parts by weight of each component in acne-removing composition B are as follows: 3 parts of herba hedyotis diffusae extract, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed mention Take 1 part of object.
5. anti-acne essence as described in claim 1 cream, which is characterized in that the essence cream also include Fructus psidii guajavae immaturus extract 1~ 2% and cork tree extract 0.012~0.02%.
6. anti-acne essence cream as described in claim 1, which is characterized in that the essence cream also includes skin-active ingredient;The skin-active Ingredient includes niacinamide;Weight percentage of the niacinamide in the essence cream is 1.6~2.4%.
7. anti-acne essence cream as described in claim 1, which is characterized in that the essence cream also includes moisturizer;The moisturizer Include glycerol, Natrulon H-10, ethoxy urea, trehalose and propylene glycol;In the essence cream, the weight of each ingredient of moisturizer Percentage composition are as follows: glycerol 2.5~3.5%, Natrulon H-10 1.6~2.4%, ethoxy urea 0.7~1.3%, trehalose 0.4~ 0.6% and propylene glycol 0.14~0.2%.
8. anti-acne essence cream as claimed in claim 7, which is characterized in that the essence cream also includes emollient, emulsifier and increasing Thick dose;The emollient includes isopropyl myristate, cetostearyl alcohol, dimethyl silicone polymer and ethylhexyl palmitate; The emulsifier includes stearine, PEG-100 stearate and PEG-20 stearate;The thickener includes card wave Nurse.
9. anti-acne essence cream as claimed in claim 4, which is characterized in that the essence cream includes the group of following weight percentage Point: acne-removing composition A 0.4~0.6%, acne-removing composition B 0.4~0.6%, Fructus psidii guajavae immaturus extract 1~2%, cork tree mention Take object 0.012~0.02%, niacinamide 1.6~2.4%, glycerol 2.5~3.5%, Natrulon H-10 1.6~2.4%, ethoxy Urea 0.7~1.3%, trehalose 0.4~0.6%, propylene glycol 0.14~0.2%, isopropyl myristate 2.5~3.5%, spermaceti Stearyl alcohol 2.4~3.5%, dimethyl silicone polymer 1.6~2.4%, ethylhexyl palmitate 1.6~2.4%, glycerol stearate Ester 0.4~0.6%, PEG-100 stearate 0.4~0.6%, PEG-20 stearate 0.15~0.25% and carbomer 0.07 ~0.13%.
10. anti-acne essence cream as claimed in claim 4, which is characterized in that the essence cream includes following weight percentage Component: acne-removing composition A0.5%, acne-removing composition B 0.5%, Fructus psidii guajavae immaturus extract 1.5%, cork tree extract 0.016%, niacinamide 2%, glycerol 3%, Natrulon H-10 2%, ethoxy urea 1%, trehalose 0.5%, propylene glycol 0.18%, Isopropyl myristate 3%, cetostearyl alcohol 2.8%, dimethyl silicone polymer 2%, ethylhexyl palmitate 2%, glycerol are hard Resin acid ester 0.5%, PEG-100 stearate 0.5%, PEG-20 stearate 0.2% and carbomer 0.1%.
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CN109568245A (en) * 2019-02-14 2019-04-05 重庆市洲仨科技发展有限公司 A kind of compound polyphenol anti-acne essence cream
CN110721127A (en) * 2019-10-21 2020-01-24 洛阳宁邦生物制药有限公司 Acne-removing lotion and preparation method thereof
CN110721139A (en) * 2019-10-30 2020-01-24 广东密尚生物科技有限公司 Oil-controlling acne-removing composition and preparation method and application thereof
CN111588815A (en) * 2020-05-29 2020-08-28 溯源生命科技股份有限公司 Acne-removing traditional Chinese medicine composition, application thereof and acne-removing balancing essence containing composition
CN111588815B (en) * 2020-05-29 2021-12-14 溯源生命科技股份有限公司 External acne-removing traditional Chinese medicine composition, application thereof and acne-removing balancing essence containing composition
CN111743831A (en) * 2020-06-24 2020-10-09 广州品赫生物科技有限公司 Acne removing composition
CN112245311A (en) * 2020-11-19 2021-01-22 泉后(广州)生物科技研究院有限公司 Acne removing composition
CN112426390A (en) * 2020-12-22 2021-03-02 广州天翼化妆品有限公司 Natural traditional Chinese medicine acne-removing composition and preparation method thereof
CN114404340A (en) * 2022-03-10 2022-04-29 稳健医疗用品股份有限公司 Plant acne-removing composition and application thereof
CN114404340B (en) * 2022-03-10 2023-12-19 稳健医疗用品股份有限公司 Plant acne-removing composition and application thereof
CN115025024A (en) * 2022-07-29 2022-09-09 维怡美生物科技(广州)有限公司 Acne and acne mark removing composition and application thereof
CN115025024B (en) * 2022-07-29 2023-11-03 维怡美生物科技(广州)有限公司 Acne and mark removing composition and application thereof

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