CN109157450A - A kind of anti-acne essence cream - Google Patents
A kind of anti-acne essence cream Download PDFInfo
- Publication number
- CN109157450A CN109157450A CN201811207346.3A CN201811207346A CN109157450A CN 109157450 A CN109157450 A CN 109157450A CN 201811207346 A CN201811207346 A CN 201811207346A CN 109157450 A CN109157450 A CN 109157450A
- Authority
- CN
- China
- Prior art keywords
- acne
- extract
- essence cream
- removing composition
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of anti-acne essence creams, include acne-removing composition A；The acne-removing composition A includes Radix Salviae Miltiorrhizae root extract, cloves alabastrum extract, radix scutellariae root extract, Angelica roots, licorice root extract and Gotu Kola P.E.The present invention cooperates basic material, anti-acne essence cream is made, is adjustable the water and oil balance of skin, removes small pox, desalinate acne print, repairs impaired skin, restores skin natural health state by adding mild plant extraction ingredient.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of anti-acne essence cream.
Background technique
With the development of economy with the continuous improvement of quality of life, the anti-acne of Chinese whelk patient is realized to be improved year by year.
Chinese skin disease association, the joint investigation of adolescents in China federation are the results show that the disease incidence of China's whelk is in rise year by year
The problem of trend, 80% or more young people encountered whelk to some extent, the state of an illness it is more serious account for the 1/3 of young people with
On.
Acne is being commonly called as acne, is called " whelk ", " dark sore " or " acne ", is due to hair follicle and sebum adenemphraxis, hair
A kind of skin disease that inflammation is caused.When puberty, intracorporal hormone can stimulate hair growth, promote smegma more heavy wool
Therefore rouge, hair and sebaceous glands accumulate many substances, since this symptom is common in youth of both sexes, so just it is referred to as " the youth
Acne ".
Whelk is a kind of common chronic dermatosis, and juvenile onset number highest is mainly in face and chest and back, table
It is now the various skin injuries such as blackhead, papule, running sore, tubercle, tumour and scar, hinders appearance.The main reason of green whelk
It is that the clogging of pores as caused by the accumulation of sebum causes sebum to accumulate the acne to be formed, once infection occur will be very short
Appearance deterioration forms serious tumour in time or this is abscess.
Acne itself is not fearful, and maximum harm is not in time or acne print, acne hole, acne are easily left in irregular treatment
Scar seriously affects image.Acne hole acne scar be really inflammation invasion plus with hand squeeze the equivalent damage epidermis of skin, skin corium with
And the subcutaneous tissue of more lower section, cause the generation of the destruction of skin, the defect of tissue and scar.These problems not only serious shadow
Appearance is rung, is also acquired a certain degree of difficulty in the treatment.
So for small pox crowd, in order to completely remove small pox acne print, in addition to paying attention to diet, living habit,
A safely and effectively product for resolving poxes is essential.
Summary of the invention
A kind of anti-acne essence cream is provided it is an object of the invention to overcome the shortcomings of the prior art place.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of anti-acne essence cream includes acne-removing composition A；
Weight percentage of the acne-removing composition A in the anti-acne essence cream is 0.4~0.6%；The acne-removing composition A packet
Root extract containing Radix Salviae Miltiorrhizae, cloves alabastrum extract, radix scutellariae root extract, Angelica roots, licorice root extract and centella
Extract.
The technical scheme adopted by the invention is as follows: a kind of anti-acne essence cream, includes acne-removing composition A；The acne-removing composition A
Weight percentage in the anti-acne essence cream is 0.4~0.6%；The acne-removing composition A include Radix Salviae Miltiorrhizae root extract,
Cloves alabastrum extract, radix scutellariae root extract, Angelica roots, licorice root extract and Gotu Kola P.E.
The present invention uses above-mentioned acne-removing composition A, and Radix Salviae Miltiorrhizae root extract has effects that antibacterial, oil-control, anti-inflammatory, angelica root
Extract has the effect of activating microcirculation and removing stasis medicinal, improves follicular keratosis, and licorice root extract and Gotu Kola P.E have reconciliation, repair
The effect of, and cloves alabastrum extract and radix scutellariae root extract can promote Radix Salviae Miltiorrhizae root extract, Angelica roots, licorice
The Transdermal absorption of extract and Gotu Kola P.E etc. dredges pore, to realize " safely, effectively " anti-acne.Acne-removing composition A
It has the following characteristics that and 1) inhibits 5α-reductase activity, balance sebum secretion；2) inhibit acne correlation pathogen in hair follicle sebum
All living creatures is long, inhibiting bacteria and diminishing inflammation；3) good suppression acne activity, skin acne state caused by improving because of cosmetics；4) by promoting to inhale thoroughly
It receives, dredging pore, improve three kinds of approach collaboration promotion acne-removings of follicular keratosis.
The acne-removing composition A can realize the effect of its anti-acne in essence cream using above-mentioned additive amount, reach efficient benefit
Purpose.
Preferably, in the acne-removing composition A each component parts by weight are as follows: 10~20 parts of Radix Salviae Miltiorrhizae root extract, lilac
2~4 parts of flower bud extract, 1~3 part of radix scutellariae root extract, 1~3 part of Angelica roots, 0.5~2 part of licorice root extract and product
Avenge careless 0.5~2 part of extract.
It is highly preferred that in the acne-removing composition A each component parts by weight are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, cloves bud
3 parts of extract, 2 parts of radix scutellariae root extract, 2 parts of Angelica roots, 1 part of licorice root extract and 1 part of Gotu Kola P.E.Respectively
When its extract uses said ratio, each extract can be made to give full play to respective effect.
Preferably, the essence cream also includes acne-removing composition B；The acne-removing composition B is in the anti-acne essence cream
Weight percentage be 0.4~0.6%；The acne-removing composition B includes herba hedyotis diffusae extract, honeysuckle extract and small
Fruit Chinese honey locust seed extract.
Herba hedyotis diffusae extract has anti-inflammatory and antibacterial action, all has different degrees of antibacterial to coccus and bacillus and kills
Bacterium effect；Caulis lonicerae has antibacterial and antiinflammation, has apparent Antibacterial Activity to S. aureus L-forms and propionibacterium acnes.Institute
Each extract cooperation of acne-removing composition B is stated, there is significant inhibiting effect to 5α-reductase, acne symptom can be mitigated, desalinate
Acne print, while having effects that oil-control.Acne-removing composition B and acne-removing composition A cooperate jointly, can effectively mitigate small pox, help thin
Born of the same parents live again, and repair impaired cell tissue, and activation fibr tissue is rebuild, and it is smoothly fine and smooth to go back skin, smooth it is coarse, keep the skin wet and
Nutrition enables skin softness, water moisten, is flexible, realizes that small pox is eliminated completely.And the acne-removing composition B in essence cream using upper
Stating additive amount can realize that it desalinates the effect of acne print, realize the efficient utilization of acne-removing composition B.
Preferably, in the acne-removing composition B each component parts by weight are as follows: 2~4 parts of herba hedyotis diffusae extract, honeysuckle
0.5~2 part of 2~4 parts of extract and fruitlet Chinese honey locust seed extract.When its each extract uses said ratio, each extraction can be made
Object gives full play to respective effect.
It is highly preferred that in the acne-removing composition B each component parts by weight are as follows: 3 parts of herba hedyotis diffusae extract, honeysuckle mention
Take 1 part of 3 parts of object and fruitlet Chinese honey locust seed extract.
Preferably, the essence cream also includes Fructus psidii guajavae immaturus extract 1~2% and cork tree extract 0.012~0.02%.
The effect of Fructus psidii guajavae immaturus extract and cork tree extract all have antiphlogistic antibacterial, using above-mentioned additive amount and acne-removing composition A and
Acne-removing composition B cooperates jointly plays its effect.
Preferably, the essence cream also includes skin-active ingredient；The skin-active ingredient includes niacinamide；The niacinamide is in institute
Stating the weight percentage in essence cream is 1.6~2.4%.
Above-mentioned skin-active ingredient can infiltrate thoroughly cuticula with Cucumber Extract, and skin is promoted to combine acne-removing composition A, anti-acne
The absorption of the plant extracts such as object B, Fructus psidii guajavae immaturus extract and cork tree extract, improves hair follicle keratinization, can more have
Imitate antibacterial, anti-inflammatory and oil-control.
Preferably, the essence cream also includes moisturizer；The moisturizer include glycerol, Natrulon H-10, ethoxy urea,
Trehalose and propylene glycol；In the essence cream, the weight percentage of each ingredient of moisturizer are as follows: glycerol 2.5~3.5% gathers
Glycerol -10 1.6~2.4%, ethoxy urea 0.7~1.3%, trehalose 0.4~0.6% and propylene glycol 0.14~0.2%.
Preferably, the essence cream also includes emollient, emulsifier and thickener；The emollient includes that myristic acid is different
Propyl ester, cetostearyl alcohol, dimethyl silicone polymer and ethylhexyl palmitate；The emulsifier include stearine,
PEG-100 stearate and PEG-20 stearate；The thickener includes carbomer.
Preferably, the essence cream includes the component of following weight percentage: acne-removing composition A0.4~0.6% is dispelled
Acne composition B 0.4~0.6%, Fructus psidii guajavae immaturus extract 1~2%, cork tree extract 0.012~0.02%, niacinamide 1.5~
2.4%, menthol 0.016~0.025%, camphor 0.008~0.013%, borneol 0.007~0.012%, propylene glycol 1.8~
2.8%, glycerol 0.8~1.2%, Cremophor RH40 0.4~0.5%, carbomer 0.15~0.25%, hydroxy ethyl fiber
Element 0.04~0.06% and EDETATE SODIUM 0.04~0.06%.Have the water oil for adjusting skin flat using the essence cream of said ratio
Weighing apparatus, the effect of anti-inflammatory and desalination acne print.
It is highly preferred that the essence cream includes the component of following weight percentage: acne-removing composition A0.5%, anti-acne group
Close object B 0.5%, Fructus psidii guajavae immaturus extract 2.5%, cork tree extract 0.025%, niacinamide 2%, menthol 0.02%, camphor
0.01%, borneol 0.01%, propylene glycol 2.21%, glycerol 1%, Cremophor RH40 0.45%, carbomer 0.2%, hydroxyl
Ethyl cellulose 0.05% and EDETATE SODIUM 0.05%.It is best using the essence cream anti-acne effect of above-mentioned formula.
Preferably, the essence cream further includes preservative；The preservative is methyl hydroxybenzoate, Nipasol, bis- (hydroxyl first
Base) imidazolidinyl urea and iodine propilolic alcohol butyl mephenesin Carbamate mixture.
Essence cream of the present invention is in addition to said components clearly require, in the range of lossless effect of the invention,
Other adjunct ingredients, such as pH adjusting agent, essence, pigment etc. can be added or used to, those skilled in the art can be according to routine
Standard selects common content.
The beneficial effects of the present invention are: the present invention provides a kind of anti-acne essence creams, and the present invention is by adding mildly
Plant extraction ingredient cooperates basic material, and anti-acne essence cream is made, is adjustable the water and oil balance of skin, removes small pox, desalinate acne
Print repairs impaired skin, restores skin natural health state.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Examples 1 to 10
Examples 1 to 10 is the embodiment of anti-acne essence cream of the present invention, anti-acne essence cream described in Examples 1 to 6
Formula is shown in Table 1.The formula of the anti-acne essence cream of embodiment 7~10 is shown in Table 2.It is each in acne-removing composition A in Examples 1 to 10
The parts by weight of component are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, 3 parts of cloves alabastrum extract, 2 parts of radix scutellariae root extract, angelica root extract
2 parts of object, 1 part of licorice root extract and 1 part of Gotu Kola P.E；The parts by weight of each component in acne-removing composition B are as follows: oldenlandia
1 part of 3 parts of careless extract, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract.
The preparation method of anti-acne essence cream described in Examples 1 to 10 the following steps are included:
S1, by carbomer and water with hanging homogenizer homogeneous to no particle that is uniformly dispersed, it is spare；
The uniform carbomer of homogenous disperse in S2, Jiang Shui, glycerol, Natrulon H-10, ethoxy urea, trehalose and step S1
It is added in main phase pot with water, is heated with stirring to 85 DEG C, keep the temperature 20 minutes；
S3, by stearine, PEG-100 stearate, cetostearyl alcohol, PEG-20 stearate, myristic acid
Isopropyl ester, dimethyl silicone polymer, ethylhexyl palmitate, methyl hydroxybenzoate and Nipasol are added in oily phase pot, are heated to 80
DEG C, stirring is to being completely dissolved；
S4, it vacuumizes, opens homogeneous, the material in step S3 is pumped into main cooker, homogeneous 5 minutes, heat preservation is after ten minutes
Start to cool down；
S5, when being down to 50 DEG C, triethanolamine and Fructus psidii guajavae immaturus extract, cork tree extract, niacinamide, bis- (hydroxyl first is added
Base) imidazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, propylene glycol and Melaleuca alternifolia leaf oil, it is stirred until homogeneous, drops to often
Temperature is discharged after the assay was approved up to the anti-acne essence cream.
The formula of anti-acne essence cream described in 1 Examples 1 to 6 of table
Comparative example 1,2
Comparative example 1, the 2 anti-acne essence creams formula be shown in Table 2.The parts by weight of each component in acne-removing composition B are as follows: white flower
1 part of 3 parts of HERBA HEDYOTIS DIFFUSAE extract, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract.Comparative example 1,2 anti-acne essence creams
The preparation method is the same as that of Example 1~and 6.
2 embodiment 7~10 of table, comparative example 1, the 2 anti-acne essence creams formula
Through examining Examples 1 to 10, comparative example 1,2 products to meet the pertinent regulations requirement of QB/T 1857-2004, sense organ
Index (color, fragrance, structure) meets industry regulation, and physical and chemical index (pH, heat-resisting, cold-resistant, active matter) meets industry regulation.
Embodiment 11
Product Safety evaluates (experiment of human skin patch)
One, trial target: the anti-acne essence cream that Examples 1 to 10, comparative example 1,2 are prepared
Tested crowd's number: 120 people, women
Age: between 12~30 years old
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
Grouping: 12 groups, every group of 10 people, average age 25 ± 2 years old.
Two, patch method: selecting qualified spot tester, with closed patch experiment method, by tested material about 0.020g~
For 0.025g drop in spot tester, external application special adhesive tape is covered on subject back, and tested material is removed after 24 hours, after removing respectively
0.5, observation dermoreaction in 6,12,24,48 hours, records its knot according to dermoreaction grade scale in " cosmetics health specification "
Fruit.
Three, experimental result: human skin patch test result is shown: each group subject passes through Examples 1 to 10, comparative example
1, the patch test of the 2 anti-acne essence creams, in observation dermoreaction in 0.5,6,12,24,48 hour, wherein 0 skin occurs
It is safe to illustrate that the anti-acne essence cream uses for adverse reaction.
Embodiment 12
Fungistatic effect test
One, test material
1, test strain: propionibacterium acnes (ATCC6919).
2, test specimen: press S1, S2, S3, S4, S5, S6, S7, S8, S9, D1, D2 sample, 4 DEG C of storages are spare, wherein S1,
S2, S3, S4, S5, S6, S7, S8, S9, D1, D2 respectively correspond the proportion of Examples 1 to 9 and the anti-acne ingredient in comparative example 1,2.
3, culture medium: propionibacterium acnes culture medium, adjusting pH is 6.6~7.0.Agar wherein is added in solid medium
15g/L。
Two, test method
1, bacteria suspension preparation and inoculation: take freezing bacteria suspension 0.1mL in 5mL propionibacterium acnes fluid nutrient medium
In, in 37 DEG C of anaerobic condition culture 2d, to test bacteria suspension.
2, prepared by medical fluid: using normal saline dilution at test respectively S1, S2, S3, S4, S5, S6, S7, S8, S9, D1, D2
Concentration 0.1%, then gradient dilution respectively.For the first time test gradient dilution concentration be respectively 100% (sample stoste), 50%,
25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%.Test repetition measurement gradient dilution concentration is respectively for the second time
10%, 8%, 6%, 4%, 2%.
3, prepared by bacterium solution: diluting bacteria suspension with propionibacterium acnes fluid nutrient medium, makes its final bacteria concentration l06CFU/
mL。
4, culture and result interpretation: 100 μ L of bacterium solution and 100 μ L of medical fluid is added in micropore, while setting the feminine gender that bacterium is not added
The normal growth control of medical fluid is compareed and is not added, every kind of medicine does 3 in parallel, is averaged.It sets 37 DEG C of anaerobism to be incubated for, be seen after 48h
Examine result.Using muddiness is visually determined whether, data are read using direct method.As a result the premise judged is that growth control is good,
Blank control asepsis growth is clear, and other holes are increased with drug concentration gradient and the growth of bacterium is suppressed.
Table 3 first time antibacterial gradient test result
Note: wherein "+" representative has bacterium growth, and "-" represents nothing.
Second of table 4 antibacterial gradient test result
Note: wherein "+" representative has bacterium growth, and "-" represents nothing.
5, test result
From 3 result of table as it can be seen that 0.1% solution of Examples 1 to 6,12.5% concentration or more is diluted at it, it is right
Propionibacterium acnes have a good inhibiting effect, and embodiment 7~9 can be only achieved effect in 25% dilution or more, compare
It is more than 1,2 50% concentration of needs of example.From 4 result of table as it can be seen that the Mlc of Examples 1 to 6 can reach in 10% dilution,
The Mlc of embodiment 1 can reach fungistatic effect in 6% diluted concentration.From the above results, anti-acne of the present invention at
Divide minimum addition about 0.01%, the effect for inhibiting propionibacterium acnes can be basically reached, and anti-acne ingredient of the present invention is adopted
When being used in conjunction with acne-removing composition A, acne-removing composition B, Fructus psidii guajavae immaturus extract and cork tree extract, than using one of which
Or there is stronger fungistatic effect when two kinds of uses.
Embodiment 13
Clinical test is carried out to Examples 1 to 10 and comparative example 1, the 2 essence creams, specific as follows:
Number: 120 people are divided into 12 groups, every group of 10 people, male to female ratio 1:1, and face has acne
Time: 21 days
Position: face
Sample: the cream of essence described in Examples 1 to 10 and comparative example 1, comparative example 2
Evaluation: (photo is not shown) is evaluated and is taken pictures in progress according to GAGS point-score:
GAGS point-score is Doshi etc. the 1997 acne comprehensive classification system Global AcneGrading proposed
System (GAGS) is a kind of scoring method, has the characteristics that accurate, consistency is strong, quick and overall assessment effect is good.Specifically
Are as follows: according to the density of pilosebaceous unit, distribution and approximate area, acne predilection site is divided into 6 areas: Ith area, forehead, II
Area: right cheek, IIIth area: left cheek, IVth area: nose, V area Xia Ke of area, VIth area: chest and upper back.Ith area, IIth area, III area's factor score value
It is 2, IVth area, V area's factor score value are 1, and VI area's factor score value is 3, and each region skin lesion score value is that (principle is local most serious
Skin lesion determine the score value in the area): 0=is without skin lesion；1 >=1 acne；2 >=1 papules；3 >=1 running sores；4 >=1 tubercles.
Area's total score=factor score value × skin lesion score value, the sum of variant dermatotome total score are comprehensive scores.
Evaluation result is shown in Table 5.
5 Examples 1 to 10 of table and comparative example 1, the GAGS score evaluation result of the 2 essence creams
* P < 0.05VS is before use, before * * P < 0.01VS use
From table 3 it can be seen that with use it is preceding compared with, essence described in Examples 1 to 10 cream 3 days after acne score value be substantially reduced
(P < 0.05) is significantly reduced when using 7,14 and 21 days, and statistically significant (P < 0.01).As can be seen from the table,
Compared with Example 1, the comprehensive scores after using 21 days of embodiment 4~6 are higher, illustrate that acne-removing composition A and B need
It is certain to match the lower better anti-acne effect of competence exertion；Compared with Example 1, the anti-acne of embodiment 7~9 and comparative example 1,2 is imitated
Fruit is worse, illustrates acne-removing composition A, acne-removing composition B, Fructus psidii guajavae immaturus extract and cork tree extract with the use of anti-acne effect
More preferably, the anti-acne effect of embodiment 10 is worse than embodiment 1, illustrates that niacinamide plays certain auxiliary anti-acne effect.
Embodiment 14
Product effect assessment
One, trial target: the cream of anti-acne essence prepared by Examples 1 to 3
Two, tested crowd
Gender number: 90 people, men and women is than being about 1:1
Age: between 12~30 years old
Health status: subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
Grouping: being divided into 3 groups, every group of 30 people, and average age 25 ± 2 years old.
Three, test method: respectively using anti-acne essence cream prepared by Examples 1 to 3, observe and experience using effect.
Application method: it after subject cleans face, takes suitable anti-acne essence cream to be uniformly applied to face, is massaged into absorption.Often
Day sooner or later respectively using primary, adhere to using one month, at least check weekly once to understand whether there is or not whole body and local adverse reaction,
And result is recorded in detail.
Test assessment result is shown in Table 6~8.
6 embodiment of table, 1 anti-acne essence cream tries out (one month) feedback conclusive table
7 embodiment of table, 2 anti-acne essence cream tries out (one month) feedback conclusive table
8 embodiment of table, 3 anti-acne essence cream tries out (one month) feedback conclusive table
By table 6~8 it is found that the anti-acne essence cream of the embodiment of the present invention 1~3 liking and approving by subject, tested
Person indicates that anti-acne essence cream of the present invention is gentle, and can restrain pore, skin of releiving, and adjusts skin water and oil balance, deep
Layer is repaired, improves small pox skin.With the degree of recognition highest of 1 anti-acne essence cream of embodiment in Examples 1 to 3.It is all tested simultaneously
There is allergic phenomena in non-someone in person, does not also occur the situations such as pruitus, shouting pain, redness.Therefore, anti-acne essence of the present invention
Newborn mild safety, can be used for a long time.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of anti-acne essence cream, which is characterized in that include acne-removing composition A；The acne-removing composition A is in the anti-acne essence
Weight percentage in cream is 0.4~0.6%；The acne-removing composition A includes Radix Salviae Miltiorrhizae root extract, the extraction of cloves bud
Object, radix scutellariae root extract, Angelica roots, licorice root extract and Gotu Kola P.E.
2. anti-acne essence cream as described in claim 1, which is characterized in that the parts by weight of each component in the acne-removing composition A are as follows:
10~20 parts of Radix Salviae Miltiorrhizae root extract, 2~4 parts of cloves alabastrum extract, 1~3 part of radix scutellariae root extract, Angelica roots 1~3
Part, 0.5~2 part of licorice root extract and 0.5~2 part of Gotu Kola P.E；Preferably, each component in the acne-removing composition A
Parts by weight are as follows: 15 parts of Radix Salviae Miltiorrhizae root extract, 3 parts of cloves alabastrum extract, 2 parts of radix scutellariae root extract, Angelica roots 2
Part, 1 part of licorice root extract and 1 part of Gotu Kola P.E.
3. anti-acne essence cream as described in claim 1, which is characterized in that the essence cream also includes acne-removing composition B；It is described to dispel
Weight percentage of the acne composition B in the anti-acne essence cream is 0.4~0.6%；The acne-removing composition B includes white flower
HERBA HEDYOTIS DIFFUSAE extract, honeysuckle extract and fruitlet Chinese honey locust seed extract.
4. anti-acne essence cream as claimed in claim 3, which is characterized in that the parts by weight of each component in the acne-removing composition B are as follows:
0.5~2 part of 2~4 parts of herba hedyotis diffusae extract, 2~4 parts of honeysuckle extract and fruitlet Chinese honey locust seed extract；Preferably, described
The parts by weight of each component in acne-removing composition B are as follows: 3 parts of herba hedyotis diffusae extract, 3 parts of honeysuckle extract and fruitlet Chinese honey locust seed mention
Take 1 part of object.
5. anti-acne essence as described in claim 1 cream, which is characterized in that the essence cream also include Fructus psidii guajavae immaturus extract 1~
2% and cork tree extract 0.012~0.02%.
6. anti-acne essence cream as described in claim 1, which is characterized in that the essence cream also includes skin-active ingredient；The skin-active
Ingredient includes niacinamide；Weight percentage of the niacinamide in the essence cream is 1.6~2.4%.
7. anti-acne essence cream as described in claim 1, which is characterized in that the essence cream also includes moisturizer；The moisturizer
Include glycerol, Natrulon H-10, ethoxy urea, trehalose and propylene glycol；In the essence cream, the weight of each ingredient of moisturizer
Percentage composition are as follows: glycerol 2.5~3.5%, Natrulon H-10 1.6~2.4%, ethoxy urea 0.7~1.3%, trehalose 0.4~
0.6% and propylene glycol 0.14~0.2%.
8. anti-acne essence cream as claimed in claim 7, which is characterized in that the essence cream also includes emollient, emulsifier and increasing
Thick dose；The emollient includes isopropyl myristate, cetostearyl alcohol, dimethyl silicone polymer and ethylhexyl palmitate；
The emulsifier includes stearine, PEG-100 stearate and PEG-20 stearate；The thickener includes card wave
Nurse.
9. anti-acne essence cream as claimed in claim 4, which is characterized in that the essence cream includes the group of following weight percentage
Point: acne-removing composition A 0.4~0.6%, acne-removing composition B 0.4~0.6%, Fructus psidii guajavae immaturus extract 1~2%, cork tree mention
Take object 0.012~0.02%, niacinamide 1.6~2.4%, glycerol 2.5~3.5%, Natrulon H-10 1.6~2.4%, ethoxy
Urea 0.7~1.3%, trehalose 0.4~0.6%, propylene glycol 0.14~0.2%, isopropyl myristate 2.5~3.5%, spermaceti
Stearyl alcohol 2.4~3.5%, dimethyl silicone polymer 1.6~2.4%, ethylhexyl palmitate 1.6~2.4%, glycerol stearate
Ester 0.4~0.6%, PEG-100 stearate 0.4~0.6%, PEG-20 stearate 0.15~0.25% and carbomer 0.07
~0.13%.
10. anti-acne essence cream as claimed in claim 4, which is characterized in that the essence cream includes following weight percentage
Component: acne-removing composition A0.5%, acne-removing composition B 0.5%, Fructus psidii guajavae immaturus extract 1.5%, cork tree extract
0.016%, niacinamide 2%, glycerol 3%, Natrulon H-10 2%, ethoxy urea 1%, trehalose 0.5%, propylene glycol 0.18%,
Isopropyl myristate 3%, cetostearyl alcohol 2.8%, dimethyl silicone polymer 2%, ethylhexyl palmitate 2%, glycerol are hard
Resin acid ester 0.5%, PEG-100 stearate 0.5%, PEG-20 stearate 0.2% and carbomer 0.1%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811207346.3A CN109157450B (en) | 2018-10-16 | 2018-10-16 | Acne-removing essence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811207346.3A CN109157450B (en) | 2018-10-16 | 2018-10-16 | Acne-removing essence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109157450A true CN109157450A (en) | 2019-01-08 |
| CN109157450B CN109157450B (en) | 2021-06-15 |
Family
ID=64878445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811207346.3A Active CN109157450B (en) | 2018-10-16 | 2018-10-16 | Acne-removing essence |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109157450B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568245A (en) * | 2019-02-14 | 2019-04-05 | 重庆市洲仨科技发展有限公司 | A kind of compound polyphenol anti-acne essence cream |
| CN110721139A (en) * | 2019-10-30 | 2020-01-24 | 广东密尚生物科技有限公司 | Oil-controlling acne-removing composition and preparation method and application thereof |
| CN110721127A (en) * | 2019-10-21 | 2020-01-24 | 洛阳宁邦生物制药有限公司 | Acne-removing lotion and preparation method thereof |
| CN111588815A (en) * | 2020-05-29 | 2020-08-28 | 溯源生命科技股份有限公司 | Acne-removing traditional Chinese medicine composition, application thereof and acne-removing balancing essence containing composition |
| CN111743831A (en) * | 2020-06-24 | 2020-10-09 | 广州品赫生物科技有限公司 | Acne removing composition |
| CN112245311A (en) * | 2020-11-19 | 2021-01-22 | 泉后(广州)生物科技研究院有限公司 | Acne removing composition |
| CN112426390A (en) * | 2020-12-22 | 2021-03-02 | 广州天翼化妆品有限公司 | Natural traditional Chinese medicine acne-removing composition and preparation method thereof |
| CN114404340A (en) * | 2022-03-10 | 2022-04-29 | 稳健医疗用品股份有限公司 | Plant acne-removing composition and application thereof |
| CN115025024A (en) * | 2022-07-29 | 2022-09-09 | 维怡美生物科技(广州)有限公司 | Acne and acne mark removing composition and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023135186A1 (en) * | 2022-01-12 | 2023-07-20 | S-Biomedic Nv | Skin care composition and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107773600A (en) * | 2016-08-26 | 2018-03-09 | 莱博药妆技术（上海）股份有限公司 | A kind of preparation method of acne compound |
-
2018
- 2018-10-16 CN CN201811207346.3A patent/CN109157450B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107773600A (en) * | 2016-08-26 | 2018-03-09 | 莱博药妆技术（上海）股份有限公司 | A kind of preparation method of acne compound |
Non-Patent Citations (3)
| Title |
|---|
| 北京普罗塔生物技术有限公司: "普素美祛痘净妍精华素", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20171013204》 * |
| 广州九屋生物科技有限公司: "Nine House 丹参原液", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20171023120》 * |
| 江西馨漫之舍化妆品有限公司: "馨漫之舍祛痘修护精华乳", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20171013173》 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568245A (en) * | 2019-02-14 | 2019-04-05 | 重庆市洲仨科技发展有限公司 | A kind of compound polyphenol anti-acne essence cream |
| CN110721127A (en) * | 2019-10-21 | 2020-01-24 | 洛阳宁邦生物制药有限公司 | Acne-removing lotion and preparation method thereof |
| CN110721139A (en) * | 2019-10-30 | 2020-01-24 | 广东密尚生物科技有限公司 | Oil-controlling acne-removing composition and preparation method and application thereof |
| CN111588815A (en) * | 2020-05-29 | 2020-08-28 | 溯源生命科技股份有限公司 | Acne-removing traditional Chinese medicine composition, application thereof and acne-removing balancing essence containing composition |
| CN111588815B (en) * | 2020-05-29 | 2021-12-14 | 溯源生命科技股份有限公司 | External acne-removing traditional Chinese medicine composition, application thereof and acne-removing balancing essence containing composition |
| CN111743831A (en) * | 2020-06-24 | 2020-10-09 | 广州品赫生物科技有限公司 | Acne removing composition |
| CN112245311A (en) * | 2020-11-19 | 2021-01-22 | 泉后(广州)生物科技研究院有限公司 | Acne removing composition |
| CN112426390A (en) * | 2020-12-22 | 2021-03-02 | 广州天翼化妆品有限公司 | Natural traditional Chinese medicine acne-removing composition and preparation method thereof |
| CN114404340A (en) * | 2022-03-10 | 2022-04-29 | 稳健医疗用品股份有限公司 | Plant acne-removing composition and application thereof |
| CN114404340B (en) * | 2022-03-10 | 2023-12-19 | 稳健医疗用品股份有限公司 | Plant acne-removing composition and application thereof |
| CN115025024A (en) * | 2022-07-29 | 2022-09-09 | 维怡美生物科技(广州)有限公司 | Acne and acne mark removing composition and application thereof |
| CN115025024B (en) * | 2022-07-29 | 2023-11-03 | 维怡美生物科技(广州)有限公司 | Acne and mark removing composition and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109157450B (en) | 2021-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109157450A (en) | A kind of anti-acne essence cream | |
| CN108969429A (en) | A kind of anti-acne essence | |
| CN106580797B (en) | A kind of whitening and spot eliminating cream and preparation method thereof | |
| CN109157451A (en) | A kind of anti-acne mildy wash | |
| CN105012479B (en) | A kind of acne-removing composition and its application and the Whelk-eliminating paste containing the acne-removing composition | |
| CN108969446B (en) | Infant anti-chap skin care composition for enhancing skin barrier function and preparation method thereof | |
| WO2015135313A1 (en) | Borojo skin care product and use thereof for natural moisturizing, anti-ageing, anti-uv, anti-anaphylaxis and whitening | |
| CN108670943A (en) | A kind of moisturizing, whitening, light spot composition of plant extracts | |
| CN109260075A (en) | A kind of anti-acne opsonic water | |
| CN105902418A (en) | Imitated sebum matrix, external preparation including imitated sebum matrix and application thereof | |
| KR102083294B1 (en) | A composition for skin reproduction containing extracts of abeliophyllum distichum and extract thereof having skin reproduction effect | |
| CN107184448A (en) | A kind of acne eliminating cream that there is prevention pockmark to generate | |
| CN105168063A (en) | Skin care composition with acne removing effect and preparation method thereof | |
| WO2001074326A1 (en) | Agents improving skin barrier function | |
| CN104352396A (en) | Tibetan yak butter plateau lip protector | |
| CN117045523A (en) | High-content azelaic acid composition and preparation method thereof | |
| KR102330465B1 (en) | Composition for skin comprising pine bark extract reducing edema, cellulite, breaking down body fat, promoting blood circulation and skin cream comprising thereof | |
| CN109453094A (en) | A kind of mosquito-expelling and antipruritic composition and the skin care item containing the composition | |
| CN104188859B (en) | A kind of crease-resistant skin care emulsion containing natural component extract and preparation method thereof | |
| CN116459169B (en) | Anti-inflammatory moisturizing skin external composition and preparation method and application thereof | |
| KR102368646B1 (en) | Atopy treatment lotion utilizing room temperature emulsifying process | |
| CN108113924A (en) | A kind of composite plant Shu Min agent and preparation method and application | |
| CN103211741B (en) | Skincare composition and lotion with anti-acne effect, and preparation method of skincare composition | |
| CN110025508A (en) | A kind of essence cream and preparation method thereof preventing striae of pregnancy generation | |
| JP5561365B2 (en) | Long-lasting antipruritic skin preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |