CN109453094A - A kind of mosquito-expelling and antipruritic composition and the skin care item containing the composition - Google Patents
A kind of mosquito-expelling and antipruritic composition and the skin care item containing the composition Download PDFInfo
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- CN109453094A CN109453094A CN201811351566.3A CN201811351566A CN109453094A CN 109453094 A CN109453094 A CN 109453094A CN 201811351566 A CN201811351566 A CN 201811351566A CN 109453094 A CN109453094 A CN 109453094A
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- mosquito
- expelling
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- extract
- oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a kind of mosquito-expelling and antipruritic composition and containing the skin care item of the composition, mosquito-expelling and antipruritic composition includes the ingredient of following parts by weight: 5~30 parts of peach leaf extract, stalwart 5~30 parts of mugwort extract, 5~30 parts of honeysuckle flower extract, 10~50 parts of aloe barbadensis Miller leaf juice, 0.01~2 part of citronella oil, 0.01~1 part of lavender oil and 0.01~1 part of blue gum leaf oil.The present invention is added to peach leaf extract, stalwart mugwort extract, honeysuckle flower extract, aloe barbadensis Miller leaf juice, with good antibacterial anti-inflammatory, Shu Min is calm, alleviates pruitus, the effect of moisture-regulating skin, while also added citronella oil, lavender oil, blue gum leaf oil, with good mosquito-expelling bactericidal, pacifies and releive, the effect of deep layer maintenance skin；By adding a variety of essential oils and various plants extract, has the effect of excellent mosquito-expelling and antipruritic.
Description
Technical field
The present invention relates to technical field of daily necessities, it is specifically related to a kind of mosquito-expelling and antipruritic composition and containing the composition
Skin care item.
Background technique
Common people after mosquito bite, can all be occurred it is red and swollen, itch, the symptoms such as pain.It there is also sometimes after mosquito bite
Red and swollen surprise is itched.It should avoid excessively scratching grabbing, otherwise be particularly easy to infect, scratch the tissue fluid that can also stimulate in skin, leaching
The exudation of bar liquid, part not only can be red and swollen, and itches more grabbing, especially allergic skin, it is also possible to the more scratch the more serious, be formed large stretch of
Red and swollen mosquito when sucking blood, is also injected into saliva by its point but also thin mouth bites human skin not only, thus can spread the disease, such as
Malaria, filariasis, Japanese Type-B encephalitis etc..Therefore, the product of mosquito repellent is also many on the market at present, and it is tired to release mosquito for people
It disturbs and provides very big help.The effective component of traditional mosquito-proof spray is mostly farm chemical ingredients, although farm chemical ingredients can reach mosquito-proof
Effect, but very strong potential toxic side effect might have to human body, especially children.In addition many products are after use
Some adverse reactions, such as pachylosis are had, wound infection, pigementation etc., furthermore some products can answer quickly after drug withdrawal
Hair.So it is antibacterial with antipruritic comprehensive product research and development be present market there is an urgent need to.So for public health safety
The considerations of, it is of great value for developing the various mosquito repellent products without containing Metadelphene.
Summary of the invention
Mosquito-expelling and antipruritic composition and its application are provided it is an object of the invention to overcome the above problem, to solve to drive at present
The problem of possibility potentially danger that mosquito product itching-relieving action is insufficient, chemicals uses, and there is certain nourishing skin effect, property
It can mosquito-expelling and antipruritic composition that is mild, having both mosquito repellent and antipruritic double effects.
To achieve the above object, the technical solution adopted by the present invention is that a kind of mosquito-expelling and antipruritic composition, including following weight
The ingredient of part: 5~30 parts of peach leaf extract, stalwart 5~30 parts of mugwort extract, 5~30 parts of honeysuckle flower extract, aloe barbadensis Miller
10~50 parts of leaf juice, 0.01~2 part of citronella oil, 0.01~1 part of lavender oil and 0.01~1 part of blue gum leaf oil.
Peach leaf extract: peach leaf is the leaf of rosaceous plant peach (Prunus.persica (L) Batsch), and the whole nation extensively has
Distribution.Peach leaf has good medical value, has in civil peach leaf as the folk prescription for treating for example diseases such as prickly heat remote
History.According to Chinese herbal medicine chemical analysis, peach leaf contains peach leaf and contains lycopene (lycopene), naringenin (Naringenin)
With the effective medicinal components such as quininic acid (Quinic acid).Lycopene has various biological effect, such as singlet-oxygen quenching
With remove free radical, connecting communication between inducing cell, control tumour cell increment etc..Naringenin have antibacterial, anti-inflammatory, anticancer,
Spasmolysis and choleretic effect.Quininic acid has antibacterial anti-inflammatory desinsection and other effects.
Stalwart mugwort extract: stalwart wormwood artemisia contains volatile oil, and main component is stagnant by leaf oil element, absinthol, thujanol, sequiterpene
Deng.Studies have shown that antipruritic medicine contains the extract of stalwart wormwood artemisia, it can extremely effective prevent the scabies that kidney failure or disease in the liver and gallbladder are easily sent out
Itch.
Honeysuckle flower extract: honeysuckle flower extract: the stem of honeysuckle, spends middle main ingredient for chlorogenic acid at leaf, and chlorogenic acid exists
Clinically has the function of antibacterial anti-inflammatory.Its action and efficacy is embodied in anti-inflammatory, two aspect of antibacterial.
Aloe barbadensis Miller leaf juice: the bradykinin enzyme of aloe is combined with vasotonia can resist inflammation.Especially aloe
Polysaccharide can enhance human body to the resistance of disease, cure dermatitis, chronic nephritis, cystitis, bronchitis chronic diseases disease,
Aloe juice has disinfection, antisepsis well.Asparagus juice is coated on summer skin, mosquito does not sting.Finger swelling and pain, toothache and
When being difficult to endure, aloe leave is sticked in affected part, pain, neuralgia, gout, muscles pain etc. can be eliminated.
Citronella oil: citronella oil is also known as vanilla flavour concentrate or citronella oil, obtains light yellow liquid through steam distillation by the herb of lemongrass
It is citronellal, geraniol and citronellol that body, which has strong Chinese pepper fragrance main component,.For extracting citronellal, for synthesis of hydroxy
Citronellal, geraniol and menthol.It also is used as insecticide, anophelifuge and soap perfume.
Lavender oil: lavender oil: lavender is known as " after vanilla ", is suitble to any skin, promotes cytothesis, accelerates
Wound healing, fragrance energy refreshment eyesight improving, makes one comfortable, moreover it is possible to repel mosquitoes and flies.Lavender, which impregnates oil, to be extracted with camellia seed oil
The effective component of lavender.Lavender, which impregnates oil, can inhibit the growth of bacterium, avoids causing skin infection, pacifies skin, balances
Skin oil and fat hypersecretion, analgesic anti-melancholy, are sterilized, are sterilized, decongest swelling and expelling parasite, calming and get well.It is suitable for
Any skin, treatment burn, tan severely, and promote cytothesis, balance sebum secretion；Improve acne, abscess, eczema；It prevents bald；
Expelling parasite is sterilized, clearing liver, spleen, promotes functions of intestines and stomach, anti-nausea, improve physiological problem；Improve bronchitis, asthma, laryngitis；It is stable
Mood, blood pressure lowering, controls insomnia at anti-depression.
Blue gum leaf oil: eucalyptus oil is to use steam distillation from the leaf, branch of blue gum, folium eucalypti tree, cinnamomum camphora tree and camphor tree etc.
Essential oil is extracted, 1, 8-Cineole (80% or more), amphene, phellandrene, terpinol, geranyl alcohol, isopentyl aldehyde, perfume (or spice) are mainly contained
Thatch aldehyde and piperitone, can refrigerant body, analgesic, antibacterial, and inflammation symptom can be alleviated.
Present inventor's discovery, with peach leaf extract, stalwart mugwort extract, honeysuckle flower extract and Aloe Barbadensis Miller
Juice is antipruritic active ingredients, and using citronella oil, lavender oil, blue gum leaf oil as anophelifuge activity ingredient, these types of ingredient is answered
With with good mosquito-expelling and antipruritic effect.
Preferably, 15~25 parts by weight of peach leaf extract, stalwart 15~20 parts by weight of mugwort extract, honeysuckle flowers are extracted
20~30 parts by weight of object, 40~50 parts by weight of aloe barbadensis Miller leaf juice.In mosquito repellent composition of the present invention, constituent content will affect effect
Fruit, the study found that in the peach leaf extract, stalwart mugwort extract, honeysuckle flower extract, aloe barbadensis Miller leaf juice preferred
Within the scope of weight proportion, antipruritic effect of the present invention is more preferably.
Preferably, 0.1~0.8 parts by weight of citronella oil, 0.2~0.6 parts by weight of lavender oil and blue gum leaf oil 0.1~
0.5 parts by weight.In mosquito-expelling and antipruritic composition of the present invention, citronella oil, lavender oil and Eucalyptus globulus Labill leaf oil ingredient content will affect effect,
The study found that repelling effect of the present invention is more preferably within the scope of the preferred weight proportion.
Preferably, the mosquito-expelling and antipruritic composition includes the ingredient of following parts by weight: 25 parts of peach leaf extract, stalwart mugwort mention
Take 15 parts of object, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice, 0.8 part of citronella oil, 0.6 part of lavender oil and blue gum
0.5 part of leaf oil.Present inventor has been surprisingly found that, when the mosquito-expelling and antipruritic composition is under the specific weight proportion, drives
Mosquito antipruritic effect reaches best simultaneously.
Preferably, the peach leaf extract, stalwart mugwort extract, honeysuckle flower extract, aloe barbadensis Miller leaf juice weight
Amount is than being 5:3:4:8.Present inventor's discovery, in the identical situation of mosquito-expelling and antipruritic composition additive amount, the ingredient
Weight ratio will affect antipruritic effect, and find by lot of experiments, and each ingredient is antipruritic herein under specific weight ratio
Effect is preferable.
Preferably, the citronella oil, lavender oil, blue gum leaf oil weight ratio are 0.5:0.3:0.4.The present application human hair
Existing, in the identical situation of mosquito-expelling and antipruritic composition additive amount, the weight ratio of the ingredient will affect antipruritic effect, and through excessive
Amount experimental studies have found that, for each ingredient herein under specific weight ratio, repelling effect is preferable.
The present invention also provides the mosquito-expelling and antipruritic compositions to prepare the application in skin care item.
Invention further provides a kind of skin care item containing the mosquito-expelling and antipruritic composition.
Preferably, weight percent of the composition in the skin care item is 2~8%.As mosquito-expelling and antipruritic combines
The increase of the additive amount of object, the mosquito-expelling and antipruritic effect enhancing of skin care item, but obtained through inventor's experimental study, work as mosquito-expelling and antipruritic
When the additive amount of composition is greater than 2%, significant effect increases；When additive amount is greater than 8%, increase mosquito-expelling and antipruritic composition
Additive amount, its effect of effect do not change, and are decreased slightly as low, illustrate that concentration is too high, it is suppressed that its effect.When mosquito-expelling and antipruritic combines
The effect of weight percentage of the object in the skin care item is 5%, can preferably play mosquito-expelling and antipruritic composition.
Preferably, the skin care item further include surfactant, grease, thickener, moisturizer, preservative, essence, pH tune
Save agent.
The surfactant includes but is not limited to stearine/PEG-100 stearate, cetostearyl alcohol olive
Oleate, the smooth olive oleate of sorb, polysorbate -60, the smooth stearate of sorb, cetostearyl alcohol/cetearyl Portugal
Glucosides, stereth -2, one or more of stereth -21.
The grease includes but is not limited to jojoba seed oil, Butyrospermum parkii fruit rouge, ethylhexyl palmitate, cocoa butter, meat
Isopropyl myristate, isononyl isononanoate hydrogenate poly- certain herbaceous plants with big flowers alkene, Prunus Amygdalus Dulcis Oil, olive oil, camellia seed oil one or more.
The thickener includes but is not limited to xanthan gum, carbomer, one or more of hydroxyethyl cellulose.
The moisturizer includes but is not limited to glycerol, propylene glycol, butanediol, 1,3-PD, dipropylene glycol, and 1,2- penta 2
Alcohol, 1,2- hexylene glycol, polyethylene glycol-8, polyethylene glycol -32, glycerin polyether -26, glycine betaine, trehalose, erythrite, urea, thoroughly
Bright matter acid sodium, polyglutamic acid sodium hydrolyze Scleroglucan, tremella polysaccharides, one or more of tamarind seed polysaccharide.
The preservative includes but is not limited to Phenoxyethanol, Sensiva SC50, methyl hydroxybenzoate, the third rouge of oxybenzene, and methyl is different
Thiazolinone, Bis(hydroxymethyl)imidazolidinyl urea, Chlorphenesin, potassium sorbate, one or more of sodium benzoate.
The PH regulator includes but is not limited to triethanolamine, aminomethyl propanol, potassium hydroxide, sodium hydroxide, arginine,
Citric acid, one or more of sodium citrate.
Preferably, the dosage form of the skin care item is aqua, creme, finish, washing lotion or emulsion.Skin care item of the present invention
It can be toner, essence, facial mask, lotion or creams.In addition to said components clearly require, in lossless effect of the invention
In the range of fruit, those skilled in the art can be added or used to other adjunct ingredients according to specific skin care item dosage form.
Beneficial effects of the present invention: the present invention is added to peach leaf extract, stalwart mugwort extract, honeysuckle flower extract, library
Drag-line aloe leaf juice has good antibacterial anti-inflammatory, Shu Min calmness, alleviates pruitus, the effect of moisture-regulating skin, together
When, the present invention also added citronella oil, lavender oil, and blue gum leaf oil has good mosquito-expelling bactericidal, pacifies and releive, deep layer is repaired
The effect of sheath skin；By adding a variety of essential oils and various plants extract, has the effect of excellent mosquito-expelling and antipruritic.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Each raw material involved by following embodiment is the commercially available universal product unless otherwise instructed.
The preparation method of peach leaf extract, stalwart mugwort extract, honeysuckle flower extract of the invention: fresh plant (peach is taken
Leaf/chief's mugwort/honeysuckle), it crushes, raw material powder is sent into supercritical extraction reactor and carries out supercritical carbon dioxide extracting, will be extracted
It takes mixture to be sent into overcritical separating still to be separated, separation product, which is added in distilled water, is distilled, recycling of condensed steam
Obtain plant extraction liquid.
The preparation method of mosquito-expelling and antipruritic composition of the invention: peach leaf extract, stalwart mugwort extract, honeysuckle flowers are extracted
Object, aloe barbadensis Miller leaf juice material sequentially add in emulsion pot, stir 10 minutes, are allowed to uniformly mixed.Then perfume (or spice) is sequentially added
Thatch oil, lavender oil and blue gum leaf oil material stir 10 minutes, are into plastic barrel with the discharging of 400 mesh filter clothes after mixing
It can.
Phenoxyethanol mentioned in the present invention/Sensiva SC50 expression is made of Phenoxyethanol, Sensiva SC50
Compound, the smooth olive oleate expression of cetostearyl alcohol olive oleate/sorb is by cetostearyl alcohol olive oleate, mountain
The compound of pears smooth olive oleate composition, stearine/PEG-100 stearate expression be by stearine,
The compound of PEG-100 stearate composition.Mentioned component is all made of the commercially available universal product.
Embodiment 1
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 25 parts of peach leaf extract, stalwart 15 parts of mugwort extract, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice,
0.8 part of citronella oil, 0.6 part of lavender oil and 0.5 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.
The preparation method of the skin care item of the present embodiment is 1) by glycerol, propylene glycol, carbomer, Sodium Hyaluronate, trehalose
Agitated kettle pot is added with methyl hydroxybenzoate, heating stirring is dispersed with stirring uniformly to 80~85 degree；2) 20 minutes are kept the temperature, then opened cold
But water cools to 45~50 degree；3) triethanolamine, mosquito-expelling and antipruritic composition, Phenoxyethanol/Sensiva SC50 and essence is added,
It stirs evenly, stirs 10 minutes, discharge after detection is qualified.
Embodiment 2
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
The ingredient of part: 5 parts of peach leaf extract, stalwart 8 parts of mugwort extract, 30 parts of honeysuckle flower extract, 10 parts of aloe barbadensis Miller leaf juice, perfume
0.8 part of thatch oil, 0.6 part of lavender oil and 0.5 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.
The preparation method of the skin care item of the present embodiment is same as Example 1.
Embodiment 3
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
The ingredient of part: 10 parts of peach leaf extract, stalwart 5 parts of mugwort extract, 5 parts of honeysuckle flower extract, 20 parts of aloe barbadensis Miller leaf juice, perfume
0.8 part of thatch oil, 0.6 part of lavender oil and 0.5 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.
The preparation method of the skin care item of the present embodiment is same as Example 1.
Embodiment 4
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 15 parts of peach leaf extract, stalwart 20 parts of mugwort extract, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice,
0.8 part of citronella oil, 0.6 part of lavender oil and 0.5 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.
The preparation method of the skin care item of the present embodiment is same as Example 1.
Embodiment 5
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 25 parts of peach leaf extract, stalwart 20 parts of mugwort extract, 30 parts of honeysuckle flower extract, 50 parts of aloe barbadensis Miller leaf juice,
0.8 part of citronella oil, 0.6 part of lavender oil and 0.5 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.
The preparation method of the skin care item of the present embodiment is same as Example 1.
Embodiment 6
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 30 parts of peach leaf extract, stalwart 30 parts of mugwort extract, 30 parts of honeysuckle flower extract, 10 parts of aloe barbadensis Miller leaf juice,
0.8 part of citronella oil, 0.6 part of lavender oil and 0.5 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.
The preparation method of the skin care item of the present embodiment is same as Example 1.
Embodiment 7
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 25 parts of peach leaf extract, stalwart 15 parts of mugwort extract, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice,
0.01 part of citronella oil, 0.05 part of lavender oil and 0.01 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, cetostearyl alcohol olive oleate/smooth olive oleate 2% of sorb, stearine/
PEG-100 stearate 1.5%, cetostearyl alcohol 2%, Parleam 5%, dimethyl silicone polymer 2%, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester 5%, methyl hydroxybenzoate 0.2%, the third rouge of oxybenzene 0.1%, glycerol 10%, 1,3-BDO 5%, Sodium Hyaluronate
0.1%, xanthan gum 0.2%, glycine betaine 5%, Phenoxyethanol/Sensiva SC50 0.5%, essence 0.2% and surplus go from
Sub- water.
The preparation method of the skin care item of the present embodiment is the following steps are included: 1) by cetostearyl alcohol olive oleate/sorb
Smooth olive oleate, stearine/PEG-100 stearate, cetostearyl alcohol, Parleam, poly dimethyl silicon
Oily phase pot is added in oxygen alkane, caprylic/capric triglyceride, methyl hydroxybenzoate, the third rouge of oxybenzene, and for heating stirring to 80~85 degree, stirring is equal
It is even；2) glycerol, 1,3-BDO, Sodium Hyaluronate, xanthan gum and glycine betaine are added in water phase pot, heating stirring to 80~85
Degree, stirs evenly；3) material in water phase pot is pumped into emulsion pot, material in oily phase pot is pumped into emulsion pot, is stirred evenly,
Then it will be vacuumized in emulsion pot, emulsifying 8 minutes；4) 20 minutes are kept the temperature, then opens cooling water temperature to 45~50 degree；5)
Mosquito-expelling and antipruritic composition, Phenoxyethanol/Sensiva SC50 and essence is added, stirs evenly, stirs 10 minutes, after detection is qualified
Discharging.
Embodiment 8
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 25 parts of peach leaf extract, stalwart 15 parts of mugwort extract, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice,
0.1 part of citronella oil, 0.2 part of lavender oil and 0.1 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, cetostearyl alcohol olive oleate/smooth olive oleate 2% of sorb, stearine/
PEG-100 stearate 1.5%, cetostearyl alcohol 2%, Parleam 5%, dimethyl silicone polymer 2%, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester 5%, methyl hydroxybenzoate 0.2%, the third rouge of oxybenzene 0.1%, glycerol 10%, 1,3-BDO 5%, Sodium Hyaluronate
0.1%, xanthan gum 0.2%, glycine betaine 5%, Phenoxyethanol/Sensiva SC50 0.5%, essence 0.2% and surplus go from
Sub- water.
The preparation method of the skin care item of the present embodiment is same as Example 7.
Embodiment 9
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 25 parts of peach leaf extract, stalwart 15 parts of mugwort extract, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice,
0.5 part of citronella oil, 0.6 part of lavender oil and 0.5 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, cetostearyl alcohol olive oleate/smooth olive oleate 2% of sorb, stearine/
PEG-100 stearate 1.5%, cetostearyl alcohol 2%, Parleam 5%, dimethyl silicone polymer 2%, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester 5%, methyl hydroxybenzoate 0.2%, the third rouge of oxybenzene 0.1%, glycerol 10%, 1,3-BDO 5%, Sodium Hyaluronate
0.1%, xanthan gum 0.2%, glycine betaine 5%, Phenoxyethanol/Sensiva SC50 0.5%, essence 0.2% and surplus go from
Sub- water.
The preparation method of the skin care item of the present embodiment is same as Example 7.
Embodiment 10
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 25 parts of peach leaf extract, stalwart 15 parts of mugwort extract, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice,
2 parts of citronella oil, 1 part of lavender oil and 1 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, cetostearyl alcohol olive oleate/smooth olive oleate 2% of sorb, stearine/
PEG-100 stearate 1.5%, cetostearyl alcohol 2%, Parleam 5%, dimethyl silicone polymer 2%, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester 5%, methyl hydroxybenzoate 0.2%, the third rouge of oxybenzene 0.1%, glycerol 10%, 1,3-BDO 5%, Sodium Hyaluronate
0.1%, xanthan gum 0.2%, glycine betaine 5%, Phenoxyethanol/Sensiva SC50 0.5%, essence 0.2% and surplus go from
Sub- water.
The preparation method of the skin care item of the present embodiment is same as Example 7.
Embodiment 11
As a kind of embodiment of mosquito-expelling and antipruritic composition of the invention, the mosquito-expelling and antipruritic composition includes following weight
Part ingredient: 25 parts of peach leaf extract, stalwart 15 parts of mugwort extract, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice,
2 parts of citronella oil, 0.01 part of lavender oil and 1 part of blue gum leaf oil.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, cetostearyl alcohol olive oleate/smooth olive oleate 2% of sorb, stearine/
PEG-100 stearate 1.5%, cetostearyl alcohol 2%, Parleam 5%, dimethyl silicone polymer 2%, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester 5%, methyl hydroxybenzoate 0.2%, the third rouge of oxybenzene 0.1%, glycerol 10%, 1,3-BDO 5%, Sodium Hyaluronate
0.1%, xanthan gum 0.2%, glycine betaine 5%, Phenoxyethanol/Sensiva SC50 0.5%, essence 0.2% and surplus go from
Sub- water.
The preparation method of the skin care item of the present embodiment is same as Example 7.
Embodiment 12
The present embodiment the difference is that only with embodiment 1, described mosquito-expelling and antipruritic composition the containing in skin care item
The difference of amount, the content of the mosquito-expelling and antipruritic composition of the present embodiment are 2%.
Embodiment 13
The present embodiment the difference is that only with embodiment 1, described mosquito-expelling and antipruritic composition the containing in skin care item
The difference of amount, the content of the mosquito-expelling and antipruritic composition of the present embodiment are 3%.
Embodiment 14
The present embodiment the difference is that only with embodiment 1, described mosquito-expelling and antipruritic composition the containing in skin care item
The difference of amount, the content of the mosquito-expelling and antipruritic composition of the present embodiment are 4%.
Embodiment 15
The present embodiment the difference is that only with embodiment 1, described mosquito-expelling and antipruritic composition the containing in skin care item
The difference of amount, the content of the mosquito-expelling and antipruritic composition of the present embodiment are 6%.
Embodiment 16
The present embodiment the difference is that only with embodiment 1, described mosquito-expelling and antipruritic composition the containing in skin care item
The difference of amount, the content of the mosquito-expelling and antipruritic composition of the present embodiment are 8%.
Comparative example 1
A kind of comparative example of mosquito-expelling and antipruritic composition of the present invention, mosquito-expelling and antipruritic composition described in this comparative example is containing only peach
Leaf extract.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.The preparation method of the skin care item is same as Example 1.
Comparative example 2
A kind of comparative example of mosquito-expelling and antipruritic composition of the present invention, mosquito-expelling and antipruritic composition described in this comparative example is containing only chief
Mugwort extract.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.The preparation method of the skin care item is same as Example 1.
Comparative example 3
A kind of comparative example of mosquito-expelling and antipruritic composition of the present invention, mosquito-expelling and antipruritic composition described in this comparative example is containing only bearing
Coltsfoot extract.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.The preparation method of the skin care item is same as Example 1.
Comparative example 4
A kind of comparative example of mosquito-expelling and antipruritic composition of the present invention, mosquito-expelling and antipruritic composition described in this comparative example is containing only library
Drag-line aloe leaf juice.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.The preparation method of the skin care item is same as Example 1.
Comparative example 5
A kind of comparative example of mosquito-expelling and antipruritic composition of the present invention, mosquito-expelling and antipruritic composition described in this comparative example is containing only chief
15 parts of mugwort extract, 40 parts of aloe barbadensis Miller leaf juice.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.The preparation method of the skin care item is same as Example 1.
Comparative example 6
A kind of comparative example of mosquito-expelling and antipruritic composition of the present invention, mosquito-expelling and antipruritic composition described in this comparative example is containing only peach
25 parts of leaf extract, stalwart 15 parts, 40 parts of aloe barbadensis Miller leaf juice of extract of mugwort.
By the mosquito-expelling and antipruritic composition be applied to skin care item in, the skin care item include following weight percent at
Point: mosquito-expelling and antipruritic composition 5%, glycerol 10%, propylene glycol 2%, carbomer 0.3%, Sodium Hyaluronate 0.1%, trehalose
2%, methyl hydroxybenzoate 0.1%, triethanolamine 0.3%, Phenoxyethanol/Sensiva SC50 0.4%, essence 0.1% and surplus
Deionized water.The preparation method of the skin care item is same as Example 1.
Comparative example 7
A kind of comparative example of mosquito-expelling and antipruritic composition of the present invention, mosquito-expelling and antipruritic composition described in this comparative example and implements
The difference of the additional amount that the difference is that only mosquito-expelling and antipruritic composition of example 1, in this comparative example, the mosquito-expelling and antipruritic composition
The weight percentage of addition in the skin care item is 1.5%.
Comparative example 8
A kind of comparative example of mosquito-expelling and antipruritic composition of the present invention, mosquito-expelling and antipruritic composition described in this comparative example and implements
The difference of the additional amount that the difference is that only mosquito-expelling and antipruritic composition of example 1, in this comparative example, the mosquito-expelling and antipruritic composition
The weight percentage of addition in the skin care item is 8.5%.
Embodiment 17
The antipruritic effect of mosquito-expelling and antipruritic composition is verified
Experimental method: taking mouse, male female fifty-fifty, is randomly divided into multiple groups, examination of this experiment with physiological saline as a control group
Product prepared by embodiment 1~16 and comparative example 1~8 is applied in agent.
First day by mouse it is right after instep unhairing, and 1cm at the shaving of instep is uniformly abraded with coarse sandpaper2.Second day small
The anti-pruritic compositions of experimental group are distinguished at the surface of a wound of mouse instep, the amount of embrocating is 0.5ml/ every time.3 times a day, it embrocates altogether 7 times.In
After last embrocates 30min, histamine phosphate normal saline solution is dripped to the mouse instep surface of a wound, is then incremented by histamine phosphate every 3min
Normal saline solution concentration.Its concentration is respectively 0.01%, 0.02%, 0.03%, 0.04% incremented by successively, and concentration increases every time
0.01%, each dripping quantity 0.05ml, until mouse later licks right metapedes.The total amount of computation organization's amine, as of the invention
Cause is itched valve；Compared with blank control group, group difference analysis is carried out.The results are shown in Table 1:
The antipruritic effect of 1 mosquito-expelling and antipruritic composition of table
Compared with the control group: * is P < 0.05, and * * is P < 0.01.
As it can be seen from table 1 the skin care item of embodiment 1~17 all have good antipruritic effect.From embodiment 1 and in fact
Applying 2~6 experimental data of example can be seen that total addition level in mosquito-expelling and antipruritic composition is identical and citronella oil, lavender oil and indigo plant
Under the content same case of eucalyptus oil, the peach leaf extract of four kinds of ingredients, stalwart mugwort extract, honeysuckle flower extract, Curacao
The difference of aloe leaf juice weight, antipruritic effect have difference, as a result it is found that when peach leaf extract, stalwart mugwort extract,
In the case that honeysuckle flower extract, aloe barbadensis Miller leaf juice weight ratio are 5:3:4:8, antipruritic effect reaches best.From implementation
Example 1 and the antipruritic effect of embodiment 7~11 can be seen that, identical in the total addition level in mosquito-expelling and antipruritic composition, and peach leaf extracts
Under object, stalwart mugwort extract, honeysuckle flower extract, aloe barbadensis Miller leaf juice weight same case, only citronella oil,
The difference of lavender oil and blue gum leaf oil weight, antipruritic effect are not much different with embodiment 1, show of the invention main
Its antipruritic effect is peach leaf extract, stalwart mugwort extract, honeysuckle flower extract, aloe barbadensis Miller leaf juice.From embodiment 1 and
The comparison of comparative example 1~6 can be seen that, peach leaf extract, stalwart mugwort extract, honeysuckle flower extract, aloe barbadensis Miller leaf juice at
Divide in single use, all there is certain antipruritic effect.It is identical in additive amount when four kinds of extracts of progress are used in compounding
In the case of, better than one of, two or three of antipruritic effect is only used, the antipruritic effect after Four Plants extract compounding is most
It is good.It can be seen that from the antipruritic effect result of embodiment 1, embodiment 12~16, comparative example 7,8 with mosquito-expelling and antipruritic composition
Additive amount increase, the antipruritic effect enhancing of skin care item but obtains through inventor's experimental study, when mosquito-expelling and antipruritic composition
Additive amount be greater than 2% when, significant effect increase；When additive amount is greater than 8%, increase the addition of mosquito-expelling and antipruritic composition
Amount, its effect of effect do not change, and is decreased slightly as low, illustrates that concentration is too high, it is suppressed that its effect.Therefore, the benefit of comprehensive product
With rate and effect, show that the weight percentage when mosquito-expelling and antipruritic composition in the skin care item is 5%, can preferably play
The effect of mosquito-expelling and antipruritic composition.
Embodiment 18
The repelling effect of mosquito-expelling and antipruritic composition
Experimental method: referring to National Standard of the People's Republic of China, the indoor harmacological effect of agriculture chemical registration hygienic insecticide is commented
The method of valence repellant (GB/T17355.10-1998) is tested.It is 30cm × 30cm × 60cm mosquito in length × width × height
The aedes albopictus female mosquito that 300 4-5 ages in days are not sucked blood is put into cage.It wipes out after mouse web portion becomes mildewed, depilatory agent is applied to abdomen,
It is wiped after 5min with paper handkerchief, is rinsed well with tap water, dried with cotton balls.The depilation time does not answer too long, otherwise can destroy mouse
Skin.Test mice is fixed in the plastic plate for folding up mouse, abdomen is directed at the border circular areas (diameter for being put in hollow out
2.5cm), four limbs and tail are tightly wound with adhesive tape, cover skin.Examination mouse is put into 2min in mosquito cage, comes to stop the test worm fallen
More than 20 persons are that attack is qualified, this mouse and the cage mosquito can be used for repellency test.
Mosquito repellent test: mouse is handled with the aforedescribed process.In the abdomen skin that mouse exposes from border circular areas (diameter 2.5cm)
It (has lost hair or feathers) on skin, has uniformly smeared mosquito repellent product (embodiment 1, embodiment 7~16 and comparative example 7~8) 20 μ L for examination, it will
Examination mouse is put into mosquito cage (inside having 300 or so female mosquitos), observes 2min, and record thorn is stung the mosquito quantity of mouse, is put at interval of 1h
Bite by mosquitos has been seen whether in mosquito cage, is observed 8h altogether, is observed 2min every time.It is per treatment to set 3 mouse repetitions, it surveys average
Value, the mouse that setting abdomen smears 20 μ L dehydrated alcohols make blank control, observe the attacking ability of mosquito.Calculate each mosquito-repellent perfume
Effective Vate of Protection, calculation formula is as follows:
Effective Vate of Protection (%)=(mosquito thorn stings number after control mosquito thorn stings number-painting essential oil)/control mosquito thorn stings number
The repelling effect of 2 mosquito-expelling and antipruritic composition of table
It is learnt from table 2, skin care item of the invention all have good repelling effect, from embodiment 1 and embodiment 7~11
Comparison it is found that in the identical situation of additive amount of mosquito-expelling and antipruritic composition, and peach leaf extract, stalwart mugwort extract, bear
Under coltsfoot extract, aloe barbadensis Miller leaf juice weight same case, only citronella oil, lavender oil and blue gum leaf oil
The difference of weight, repelling effect have difference, as a result it is found that when citronella oil, lavender oil, blue gum leaf oil weight ratio are
In the case where 0.8:0.6:0.5, repelling effect reaches best.From the mosquito repellent of embodiment 1, embodiment 12~16, comparative example 7,8
Effectiveness results can be seen that the increase of the additive amount with mosquito-expelling and antipruritic composition, the repelling effect enhancing of skin care item, but pass through
Inventor's experimental study show that, when the additive amount of mosquito-expelling and antipruritic composition is greater than 2%, significant effect increases；Work as additive amount
When greater than 8%, increase the additive amount of mosquito-expelling and antipruritic composition, effect does not change, and reduces, and illustrates that concentration is too high, inhibits
Its effect.Therefore, the utilization rate and effect of comprehensive product, obtains the weight when mosquito-expelling and antipruritic composition in the skin care item
The effect of percentage composition is 5%, can preferably play mosquito-expelling and antipruritic composition.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent substitution, improvement and etc. done be should be included within the scope of the present invention.
Claims (10)
1. a kind of mosquito-expelling and antipruritic composition, which is characterized in that the ingredient including following parts by weight: 5~30 parts of peach leaf extract, chief
5~30 parts of mugwort extract, 5~30 parts of honeysuckle flower extract, 10~50 parts of aloe barbadensis Miller leaf juice, 0.01~2 part of citronella oil,
0.01~1 part and 0.01~1 part of blue gum leaf oil of lavender oil.
2. mosquito-expelling and antipruritic composition according to claim 1, which is characterized in that the peach leaf extract, stalwart mugwort extract
The parts by weight content of object, honeysuckle flower extract and aloe barbadensis Miller leaf juice is 15~25 parts of peach leaf extract, stalwart mugwort extract
15~20 parts, 20~30 parts of honeysuckle flower extract, 40~50 parts of aloe barbadensis Miller leaf juice；Preferably, the citronella oil, lavender
Oil and blue gum leaf oil parts by weight content be 0.1~0.8 part of citronella oil, 0.2~0.6 part of lavender oil and blue gum leaf oil 0.1~
0.5 part.
3. mosquito-expelling and antipruritic composition according to claim 1, which is characterized in that the ingredient including following parts by weight: peach leaf
25 parts of extract, stalwart 15 parts of mugwort extract, 20 parts of honeysuckle flower extract, 40 parts of aloe barbadensis Miller leaf juice, 0.8 part of citronella oil,
0.6 part and 0.5 part of blue gum leaf oil of lavender oil.
4. mosquito-expelling and antipruritic composition according to claim 1, which is characterized in that the peach leaf extract, stalwart mugwort extract
The weight ratio of object, honeysuckle flower extract and aloe barbadensis Miller leaf juice: peach leaf extract: stalwart mugwort extract: honeysuckle flower extract:
Aloe barbadensis Miller leaf juice is 5:3:4:8.
5. mosquito-expelling and antipruritic composition according to claim 1, which is characterized in that the citronella oil, lavender oil and blue gum
The weight ratio of leaf oil: citronella oil: lavender oil: blue gum leaf oil is 0.8:0.6:0.5.
6. mosquito-expelling and antipruritic composition is preparing the application in skin care item as described in any one of Claims 1 to 5.
7. a kind of skin care item containing the mosquito-expelling and antipruritic composition as described in any one of Claims 1 to 5.
8. skin care item as claimed in claim 7, it is characterised in that: weight percent of the composition in the skin care item
It is 2~8%, it is preferable that weight percent of the composition in the skin care item is 5%.
9. skin care item as claimed in claim 8, which is characterized in that further include surfactant, grease, thickener, moisturizer,
Preservative, essence, pH adjusting agent.
10. skin care item as claimed in claim 7, which is characterized in that the dosage form of the skin care item is aqua, creme, finish, washes
Liquid or emulsion.
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| CN111150688A (en) * | 2020-01-10 | 2020-05-15 | 广州贝玛生物科技有限公司 | Mosquito-repellent prickly heat-removing spray and preparation method thereof |
| CN111803555A (en) * | 2020-07-22 | 2020-10-23 | 广州市顺芝堂生物科技有限公司 | Compound natural plant composition and preparation method thereof |
| CN112426380A (en) * | 2020-12-07 | 2021-03-02 | 中国热带农业科学院农产品加工研究所 | Artemisia komarovii mosquito repellent and preparation method thereof |
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| CN107349170A (en) * | 2017-07-13 | 2017-11-17 | 广州暨南生物医药研究开发基地有限公司 | A kind of mugwort mosquito repellant antipruritus toilet water and preparation method thereof |
| CN108514543A (en) * | 2018-06-25 | 2018-09-11 | 廖海湘 | A kind of Chinese medicine mosquito repellent liquid |
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| CN107349170A (en) * | 2017-07-13 | 2017-11-17 | 广州暨南生物医药研究开发基地有限公司 | A kind of mugwort mosquito repellant antipruritus toilet water and preparation method thereof |
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Cited By (3)
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| CN111150688A (en) * | 2020-01-10 | 2020-05-15 | 广州贝玛生物科技有限公司 | Mosquito-repellent prickly heat-removing spray and preparation method thereof |
| CN111803555A (en) * | 2020-07-22 | 2020-10-23 | 广州市顺芝堂生物科技有限公司 | Compound natural plant composition and preparation method thereof |
| CN112426380A (en) * | 2020-12-07 | 2021-03-02 | 中国热带农业科学院农产品加工研究所 | Artemisia komarovii mosquito repellent and preparation method thereof |
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