CN107349170A - A kind of mugwort mosquito repellant antipruritus toilet water and preparation method thereof - Google Patents
A kind of mugwort mosquito repellant antipruritus toilet water and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
The invention belongs to daily chemical product technical field, and in particular to a kind of mugwort mosquito repellant antipruritus toilet water and preparation method thereof.Mugwort mosquito repellant antipruritus toilet water provided by the invention includes following components and its parts by weight：30 50 parts of 0.2 0.4 parts of P-Cymene, 0.4 0.8 parts of Lavender, 13 parts of Rosemary Oil, 0.2 0.4 parts of oil of Cymbopogon winterianus, 12 parts of menthol, 2.5 5 parts of extract solution from aloe, 5 10 parts of propolis, 13 parts of solubilizer, 40 60 parts of ethanol, 0.5 1.5 parts of anti-sensitizer and water.The present invention is cooperated using the component such as P-Cymene and Lavender, camellia seed oil, extract solution from aloe, synergy, the mosquito-repellent perfume being prepared is to no skin irritation, there are good refrigerant, mosquito repellent, detumescence, antipruritic effect, with rear mosquito repellent positive effect, excitant is small, antipruritic effect is obvious.
Description
Technical field
The invention belongs to daily chemical product technical field, and in particular to a kind of mugwort mosquito repellant antipruritus toilet water and its preparation side
Method.
Background technology
Mosquito-repellent perfume be it is a kind of containing alcohol, culicifuge, delay volatilization NMF and essence the aqueous solution, in order to up to
To refrigerant effect, menthol is contained in usual floral water, but the sporadic and cooling of menthol can be explosive strong because of it, institute
So that irritability cool and that skin can be triggered can be brought to react.To reach anti-inflammatory effects, salicylic acid is generally added, but salicylic acid
Permeability it is too high, so to skin tape carry out excitant again, and increase the drying property of skin, therefore the use of existing floral water
Comfort has much room for improvement.
Summer is in order to avoid bite by mosquitos, it is often necessary to mosquito-repellent perfume is coated with, tradition has repelling effect
Repellant such as Metadelphene (DEET), mosquitofugal oil (DMP), indalone, the O-phthalic of chemical synthesis are typically with the addition of in floral water
Dimethyl phthalate (DMP) or citronellal etc., are coated on skin, form diaphragm, make mosquito close, but above-mentioned chemical synthesis
Although repellant has spectrum repellent action, there is preferable effect to most of hematophagus, long-term or a large amount of uses
Skin lesion locally or systemically occurs, the problems such as also causing child skin allergy.
Chinese patent application CN1548028A discloses a kind of mosquito-repellent perfume, includes dimethyl phthalate 2-8% and plants essential oil
0.1-5%.Dimethyl phthalate therein is the main active of mosquito repellent.Dimethyl phthalate has certain toxicity, in use, people
The dimethyl phthalate of part is absorbed by alimentary canal, respiratory tract, can not only induce the diseases such as asthma, it is long-term use of can also it is carcinogenic,
Teratogenesis.
Chinese patent application CN103830131A discloses a kind of preparation method of floral water for children, the invention include with
Lower step：Methyl hydroxybenzoate and Folium Artemisiae Argyi extract are added in appropriate amounts of sterilized water and stirred；Dimethyl phthalate and peppermint oil are added
Enter in medical ethanol and mix；Said mixture is mixed and adds water to complement to 100%, stirs and gets product.In the present invention
Dimethyl phthalate has certain toxicity, and long-term use has deleterious effect to human body, and preparation process is comparatively laborious, and mosquito repellent is effective
Time is shorter.
The content of the invention
To solve problems of the prior art, the present invention provides a kind of mugwort mosquito repellant antipruritus toilet water and its preparation side
Method.
A kind of mugwort mosquito repellant antipruritus toilet water of the present invention, includes following components and its parts by weight：
P-Cymene 0.2-0.4 parts, Lavender 0.4-0.8 parts, Rosemary Oil 1-3 parts, oil of Cymbopogon winterianus 0.2-0.4
Part, menthol 1-2 parts, extract solution from aloe 2.5-5 parts, propolis 5-10 parts, solubilizer 1-3 parts, ethanol 40-60 parts, anti-sensitizer
0.5-1.5 parts and water 30-50 parts.
Preferably, described mugwort mosquito repellant antipruritus toilet water, is made up of following components and its parts by weight：
0.3 part of P-Cymene, 0.6 part of Lavender, 2 parts of Rosemary Oil, 0.3 part of oil of Cymbopogon winterianus, menthol 1.5
Part, 3.5 parts of extract solution from aloe, 7.5 parts of propolis, 2 parts of solubilizer, 50 parts of ethanol, 1 part of anti-sensitizer and 40 parts of water.
Preferably, the preparation method of described P-Cymene comprises the following steps：
S1, folium artemisiae argyi 200g is taken, crushed with pulverizer, load supercritical extraction unit；
S2, water-bath is opened, extraction equipment is reached 30 DEG C, be passed through CO2Air displacement in system is clean；
S3, pressure 20MPa in compressor regulation extractor is opened, regulation extractor outlet valve makes CO2Flow 15kg/h, protect
60min is held, separator is opened and takes out extract, to be extracted to finish, close compressor, steel cylinder emptying CO2, produce.
Preferably, described solubilizer is Cremophor RH40.
Preferably, described anti-sensitizer ties up element in mass ratio 2 by Radix et Caulis Opuntiae Dillenii extract and mother chrysanthemum:3 compositions.
Preferably, the preparation method of described Radix et Caulis Opuntiae Dillenii extract comprises the following steps：
S1, weigh cactus 50g and crushed 80 mesh sieves and pour into reflux, it is 1 to add 600ml volume ratios:2 ethanol
Flowed back with water mixed liquid in 75 DEG C of water-bath and filter after extraction 2h and collect filtrate I and filter residue；
S2, by the filter residue that step S1 is obtained with 600ml volume ratios be 1:4 isopropanol and water mixed liquid ultrasonic extraction
Filtered after 15min and collect filtrate II, the filtrate I and II that suction filtration is obtained merge, and are concentrated and dried and produce.
In addition, present invention also offers a kind of preparation method of mugwort mosquito repellant antipruritus toilet water, comprise the following steps：
S1, corresponding raw material is weighed by weight；
S2, by P-Cymene, Lavender, Rosemary Oil, oil of Cymbopogon winterianus, extract solution from aloe and solubilizer it is miscible after
Ethanol and menthol are added, stirs the lower water for adding dosage 50%, stir to obtain solution A；
S3, propolis is added in remaining water and is heated to 60-70 DEG C, stirred and be cooled to room temperature, obtain solution B；
S4, step S2 resulting solutions A and step S3 resulting solutions B be well mixed, add anti-sensitizer, produce.
Lavender CAS：8000-28-0；Rosemary Oil CAS：8000-25-7；Oil of Cymbopogon winterianus CAS：
73049-78-2；Menthol CAS：89-78-1；Extract solution from aloe CAS：85507-69-3；Propolis CAS：8012-89-
3；Cremophor RH40 CAS：61788-85-0；Plain No. CAS of mother chrysanthemum dimension：84776-11-4；Dipotassium glycyrrhizinate CAS：
68797-35-3。
P-Cymene contains certain biocidal efficacies composition, and extract solution from aloe has the function that anti-inflammatory and healing of wound, interior
Containing biology enzyme, by slowly hydrolyzing anti-inflammation and sterilization effect of playing with skin, and make under amino acid effect with collagen in cuticula
Use healing of wound；Propolis because its contain flavone compound and alkene, steroid and several amino acids, aliphatic acid, enzyme,
Vitamin, various trace elements etc., have sterilization, anti-inflammatory, it is antipruritic, anti-oxidant, enhancing be immunized etc. multiple functions.
Mother chrysanthemum dimension element is a kind of composite extract formed from wild chaste tree composite family shade plant root Hydrolysis kinetics, there is enhancing
The immunologic function of body cell and disease-resistant change effect, due to its unique double hydroxyl and the molecular structure of double amino, can effectively swash
The immunologic function of Skin Cell living, it is a kind of anti-sensitizer of preferably immunity enhancement type newfound in recent years, because it is unique
Molecular gene and molecular structure, the also good absorbing path for getting through Skin Cell and moisturizing promote the work of wound healing
With.
It can be seen that from test example 1 and 2：Using Radix et Caulis Opuntiae Dillenii extract and mother chrysanthemum dimension element in mass ratio 2:The antiallergic of 3 compositions
Agent is used in mugwort mosquito repellant antipruritus toilet water of the present invention so that and mosquito-repellent perfume of the present invention is safe to use, and to hyaluronidase
With good inhibiting effect, and hyaluronidase is anaphylactoid important participant.
The present invention is can be seen that using component phases such as P-Cymene and Lavender, extract solution from aloe from test example 3-5
Mutually coordinate, synergy, the mosquito-expelling and antipruritic floral water being prepared has good refrigerant, mosquito repellent, disappeared to no skin irritation
Swollen, antipruritic effect, with rear mosquito repellent positive effect, excitant is small, antipruritic effect is obvious.
Compared with prior art, the technical advantages of the present invention are that：The present invention is coordinated using P-Cymene, extract solution from aloe
The mosquito-repellent perfume that the components such as propolis, Radix et Caulis Opuntiae Dillenii extract and mother chrysanthemum dimension element are prepared is non-stimulated to skin safe, and mosquito repellent stops
Effect of itching is good.
Embodiment
The present invention is described in further details below by specific embodiment, these embodiments are only used for the mesh of illustration
, it is in no way intended to limit protection scope of the present invention.
Embodiment 1-3, comparative example 1-3
Table 1 lists the component and part of 1-3 of the embodiment of the present invention and comparative example 1-3 mosquito-expelling and antipruritic floral water.
The embodiment of table 1 and comparative example mosquito-expelling and antipruritic floral water component and part
A kind of mugwort mosquito repellant antipruritus toilet water of embodiment 1
The preparation method of described P-Cymene comprises the following steps：
S1, folium artemisiae argyi 200g is taken, crushed with pulverizer, load supercritical extraction unit；
S2, water-bath is opened, extraction equipment is reached 30 DEG C, be passed through CO2Air displacement in system is clean；
S3, pressure 20MPa in compressor regulation extractor is opened, regulation extractor outlet valve makes CO2Flow 15kg/h, protect
60min is held, separator is opened and takes out extract, to be extracted to finish, close compressor, steel cylinder emptying CO2, produce.
The preparation method of described Radix et Caulis Opuntiae Dillenii extract is：
S1, weigh cactus 50g and crushed 80 mesh sieves and pour into reflux, it is 1 to add 600ml volume ratios:2 ethanol
Flowed back with water mixed liquid in 75 DEG C of water-bath and filter after extraction 2h and collect filtrate I and filter residue；
S2, by the filter residue that step S1 is obtained with 600ml volume ratios be 1:4 isopropanol and water mixed liquid ultrasonic extraction
Filtered after 15min and collect filtrate II, the filtrate I and II that suction filtration is obtained merge, and are concentrated and dried and produce.
The preparation method of described mugwort mosquito repellant antipruritus toilet water, comprises the following steps：
S1, corresponding raw material is weighed by weight；
S2, by P-Cymene, Lavender, Rosemary Oil, oil of Cymbopogon winterianus, extract solution from aloe and solubilizer it is miscible after
Ethanol and menthol are added, stirs the lower water for adding dosage 50%, stir to obtain solution A；
S3, propolis is added in remaining water and is heated to 60 DEG C, stirred and be cooled to room temperature, obtain solution B；
S4, step S2 resulting solutions A and step S3 resulting solutions B be well mixed, add anti-sensitizer, produce.
A kind of mugwort mosquito repellant antipruritus toilet water of embodiment 2
Described P-Cymene and the preparation method of Radix et Caulis Opuntiae Dillenii extract are similar to Example 1.
The preparation method of described mugwort mosquito repellant antipruritus toilet water, comprises the following steps：
S1, corresponding raw material is weighed by weight；
S2, by P-Cymene, Lavender, Rosemary Oil, oil of Cymbopogon winterianus, extract solution from aloe and solubilizer it is miscible after
Ethanol and menthol are added, stirs the lower water for adding dosage 50%, stir to obtain solution A；
S3, propolis is added in remaining water and is heated to 65 DEG C, stirred and be cooled to room temperature, obtain solution B；
S4, step S2 resulting solutions A and step S3 resulting solutions B be well mixed, add anti-sensitizer, produce.
A kind of mugwort mosquito repellant antipruritus toilet water of embodiment 3
Described P-Cymene and the preparation method of Radix et Caulis Opuntiae Dillenii extract are similar to Example 1.
The preparation method of described mugwort mosquito repellant antipruritus toilet water, comprises the following steps：
S1, corresponding raw material is weighed by weight；
S2, by P-Cymene, Lavender, Rosemary Oil, oil of Cymbopogon winterianus, extract solution from aloe and solubilizer it is miscible after
Ethanol and menthol are added, stirs the lower water for adding dosage 50%, stir to obtain solution A；
S3, propolis is added in remaining water and is heated to 70 DEG C, stirred and be cooled to room temperature, obtain solution B；
S4, step S2 resulting solutions A and step S3 resulting solutions B be well mixed, add anti-sensitizer, produce.
A kind of mosquito-expelling and antipruritic floral water of comparative example 1
Described Radix et Caulis Opuntiae Dillenii extract and the preparation method of mosquito-expelling and antipruritic floral water are similar to Example 2.
The difference of comparative example 1 and embodiment 2 is：Without P-Cymene, increase the content of extract solution from aloe.
A kind of mosquito-expelling and antipruritic floral water of comparative example 2
The preparation method of described P-Cymene, Radix et Caulis Opuntiae Dillenii extract and mosquito-expelling and antipruritic floral water is similar to Example 2.
The difference of comparative example 2 and embodiment 2 is：Anti-sensitizer ties up element in mass ratio 1 by Radix et Caulis Opuntiae Dillenii extract and mother chrysanthemum:1
Composition.
A kind of mosquito-expelling and antipruritic floral water of comparative example 3
The preparation method of described P-Cymene, Radix et Caulis Opuntiae Dillenii extract and mosquito-expelling and antipruritic floral water is similar to Example 2.
The difference of comparative example 3 and embodiment 2 is：Anti-sensitizer is replaced with into dipotassium glycyrrhizinate.
Test example 1：Safety evaluation is tested
1. test material：Floral water prepared by embodiment 1-3, comparative example 1-3.
2. subjects：60 people, point 6 groups of every group of 10 people, health status：Subjects skin's health, no skin disease allergies,
Meet subject and volunteer inclusion criteria.
3. test method：Device is tried with closed patch experiment method from qualified spot, by tested material about 0.020-
For 0.025ml drops in spot examination device, external application special adhesive tape is covered on subject back, and tested material is removed after 12 hours, is observed respectively
0.5 after removal, dermoreaction in 6,12,24,48 hours, according to《Cosmetics health specification》Middle dermoreaction grade scale records it
As a result.
Human skin patch result is shown：60 subjects use the embodiment 1-3 for preparing of the present invention and right respectively
Ratio 1-3 floral water carries out patch test, dermoreaction is observed at 0.5,6,12,24,48 hour, wherein 0 skin occurs not
Good reaction, illustrate that experiment floral water used is safe to use.
Test example 2：Suppress hyaluronidase ability measure
1. test material：Floral water prepared by embodiment 1-3, comparative example 2-3.
2. test method：Take 0.1ml 0.25mol/L CaCl237 DEG C of heat insulating cultures of solution and 0.5ml hyaluronic acids enzyme liquid
20min, sample liquid 0.5ml is added, continue 37 DEG C of heat insulating culture 20min；Add the 37 DEG C of insulations of 0.5ml Sodium Hyaluronates liquid
30min, room temperature 5min；0.1ml 0.4mol/LNaOH and 0.5ml acetylacetone,2,4-pentanedione solution is added, is placed in boiling water bath and heats
5min is cooled down after 15min with frozen water immediately；Add Ehrlich's reagent 1.0ml and be diluted with 3.0ml absolute ethyl alcohols, placed
20min develops the color, with its absorbance of spectrophotometric determination.Measure and calculation formula of the sample to hyaluronic acid enzyme inhibition rate：Thoroughly
Bright matter acid enzyme inhibition rate (%)=[(A-B)-(C-D)]/(A-B) × 100%, A- contrast solution ABS values (use acetate buffer in formula
Liquid replaces sample solution)；B- control blank solution ABS values (replacing sample solution and enzyme liquid with acetate buffer solution)；C- samples are molten
Liquid ABS values；D- sample blank solution A BS values (replacing sample solution with acetate buffer solution).As a result it is as shown in table 2.
Table 2 suppresses hyaluronidase ability measurement result
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 2 | Comparative example 3 |
| Hyaluronic acid enzyme inhibition rate (%) | 78 | 85 | 74 | 56 | 62 |
The mugwort mosquito repellant antipruritus toilet water that as shown in Table 2 prepared by 1-3 of the embodiment of the present invention is spent compared with comparative example 2-3 mosquito-expelling and antipruritics
Dew has stronger rejection ability to hyaluronidase, illustrates the present invention using P-Cymene, Lavender, aloe extraction
Liquid, propolis and element in mass ratio 2 is tieed up by Radix et Caulis Opuntiae Dillenii extract and mother chrysanthemum:The components such as the anti-sensitizer of 3 compositions cooperate, collaboration is made
Effect is well adapted to for having for skin sensitivity crowd.And embodiment 2 is to the inhibiting rate highest of hyaluronidase
The preferred embodiments of the present invention.
Test example 3：Anti-inflammation test
1. test material：Mosquito-repellent perfume prepared by embodiment 1-3 and comparative example 1-3.
2. subjects：Small white mouse, two kinds of sexes, body weight 25-35g；Aedes albopictus, it is wild, raised by laboratory breeding.
3. test method：The ripe aedes albopictus of artificial propagation is placed in nylon yarn cylinder mould, cylinder mould size is long × wide
× a height of 40cm × 30cm × 30cm, do not supply to eat only for water in cage.By mouse web portion unhairing, pairing two-by-two is fixed on cage outer wall,
Cage wall is close at belly unhairing position, for bite by mosquitos.If 6 experimental groups, correspond to use embodiment 1-3 and comparative example 1-3 respectively
The mosquito-expelling and antipruritic cream of preparation.Each 10 small white mouses of experimental group, each experimental group apply embodiment 1-3 and comparative example 1-3 and prepared respectively
Mosquito-expelling and antipruritic floral water (every small white mouse apply 0.1ml).Put back to after painting in cage.All animals are put to death after two hours, push abdomen aside
Portion's epidermis, calculate locus coeruleus area.Embodiment 1-3 and comparative example 1-3 mosquito-expelling and antipruritics floral water mouse mosquito is stung after therapeutic action
As shown in table 3.
The mosquito-expelling and antipruritic cream of table 3 mouse mosquito is stung after therapeutic action
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Average weight/g | 31.03 | 30.89 | 31.28 | 31.12 | 30.95 | 30.87 |
| Average spot dye area/mm2 | 13.18 | 11.05 | 12.68 | 16.19 | 15.25 | 16.23 |
As can be seen from Table 3, embodiment 1-3 spots dye area it is small compared with comparative example 1-3, illustrate the present invention use P-Cymene,
Lavender, extract solution from aloe, propolis and element in mass ratio 2 is tieed up by Radix et Caulis Opuntiae Dillenii extract and mother chrysanthemum:Anti-sensitizer of 3 compositions etc.
Component cooperates, synergy, has more preferable therapeutic effect to the reaction after bite by mosquitos.Embodiment 2 is compared with embodiment 1, reality
It is smaller to apply the spot of example 3 dye area, is the preferred embodiments of the present invention.
Test example 4：Repelling effect is tested
1. test material：Mosquito-repellent perfume prepared by embodiment 1-3, comparative example 1-3.
2. subjects：Test insect：Culex pipiens pallens, the adult that 4 days non-blood is inhaled after emergence, male and female half and half；Tester：
60,20-40 year men and women of age half and half.
3. test method：Reference literature method is tested, National Standard of the People's Republic of China's agriculture chemical registration health
The 9th part repellant (GB/T13917.9-2009) of insecticide indoor pharmacodynamic test and evaluation.
1. attack is tested：Length × width × height be 40cm × 30cm × 30cm mosquito cage in be put into 300 sprout wings after 4 days
The aedes albopictus female mosquito do not sucked blood.Tester's the back of the hand exposes 4cm × 4cm skins, and remainder tightly covers.Hand is goed deep into mosquito
2min is stopped in cage, close observation, it is found that mosquito stops falling, shake arm is driven before its mouthpart will be pierced into skin, is designated as one
Test worm stops falling.Tester of the test worm for coming to stop falling more than 30 and test worm are designated as attack qualified, this person and this cage mosquito
Worm can carry out repellency test；2. repellency test：The tester qualified selected from 30 attacks, it is divided into 6 groups (respectively using implementation
Floral water prepared by example 1-3 and comparative example 1-3), 5cm × 5cm skin area is respectively drawn in its both hands the back of the hand, wherein a hand
By 1.5 μ L/cm2Dose uniformity smear floral water.By exposure 4cm × 4cm skins therein, remainder tightly covers, separately
One hand is blank.Repellent product 2h is smeared, hand is stretched into and is placed with 2min in the qualified mosquito cage of attack, observation whether there is mosquito
Come to stop to fall to suck blood.Afterwards every 2h tests once, as long as there is a mosquito to come to suck blood to sentence and make repellent product failure.Record
The effective protecting time (h) of repellent product.
4. result of the test：The effective protecting time of each mosquito-repellent perfume is as shown in table 4.
The repelling effect of table 4
As shown in Table 4,1-3 of embodiment of the present invention mosquito-repellent perfumes compared with comparative example 1-3 mosquito-repellent perfumes mosquito repellent time more
It is long, illustrate that the present invention uses P-Cymene, Lavender, extract solution from aloe, propolis and tieed up by Radix et Caulis Opuntiae Dillenii extract and mother chrysanthemum
Element in mass ratio 2:The components such as the anti-sensitizer of 3 compositions cooperate, synergy has good repelling effect.And embodiment 2
The mosquito repellent time of mosquito-repellent perfume is longer, is the preferred embodiments of the present invention.
Test example 5：Field test determines
1. test material：Mosquito-expelling and antipruritic floral water prepared by embodiment 1-3 and comparative example 1-3.
2. subjects：The volunteer of 120 20-60 year age brackets.
3. test method：Using opinion poll point system, subjects are arbitrarily divided into 6 groups, respectively with embodiment 1-3
Smeared with mosquito-expelling and antipruritic floral water prepared by comparative example 1-3 by the arm of bite by mosquitos.Use daily twice, usage time 3
My god.Every using effect total score is 5 points：5 points are best result, represent very well and very satisfied；4 points are preferable；3 points are to connect
By；Less than 3 points are bad and can not receive.Every average is as shown in table 5.
The resultant effect of table 5 investigates score
| Using effect | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Repelling effect | 4.6 | 4.9 | 4.3 | 3.7 | 3.6 | 3.7 |
| It is nonirritant | 4.4 | 4.8 | 4.4 | 3.8 | 3.6 | 3.8 |
| Detumescence, antipruritic effect | 4.6 | 4.8 | 4.2 | 3.5 | 4.0 | 4.0 |
| Smell | 4.3 | 4.8 | 4.6 | 3.7 | 3.4 | 3.9 |
| Refrigerant sense | 4.4 | 4.7 | 4.4 | 4.1 | 3.8 | 3.6 |
As can be seen from Table 5,1-3 of the embodiment of the present invention is higher compared with comparative example 1-3 scores, illustrates the present invention using folium artemisiae argyi essence
Oil, Lavender, extract solution from aloe, propolis and element in mass ratio 2 is tieed up by Radix et Caulis Opuntiae Dillenii extract and mother chrysanthemum:The antiallergic of 3 compositions
The components such as agent cooperate, synergy, there is good refrigerant, mosquito repellent, detumescence, antipruritic effect, with rear mosquito repellent positive effect,
Excitant is small, antipruritic effect is obvious.Comprehensive every using effect, the highest scoring of embodiment 2, is the preferred embodiment of the invention.
The above is only the preferred embodiment of the present invention, it should be pointed out that be above-mentioned preferred embodiment be not construed as to this
The limitation of invention, protection scope of the present invention should be defined by claim limited range.For the general of the art
For logical technical staff, some improvements and modifications can also be made without departing from the spirit and scope of the present invention, these improvement
Protection scope of the present invention is also should be regarded as with retouching.
Claims (7)
1. a kind of mugwort mosquito repellant antipruritus toilet water, it is characterised in that include following components and its parts by weight：
P-Cymene 0.2-0.4 parts, Lavender 0.4-0.8 parts, Rosemary Oil 1-3 parts, oil of Cymbopogon winterianus 0.2-0.4 parts,
Menthol 1-2 parts, extract solution from aloe 2.5-5 parts, propolis 5-10 parts, solubilizer 1-3 parts, ethanol 40-60 parts, anti-sensitizer 0.5-
1.5 parts and water 30-50 parts.
2. mugwort mosquito repellant antipruritus toilet water according to claim 1, it is characterised in that by following components and its parts by weight
Composition：
0.3 part of P-Cymene, 0.6 part of Lavender, 2 parts of Rosemary Oil, 0.3 part of oil of Cymbopogon winterianus, 1.5 parts of menthol, reed
40 parts of 3.5 parts of luxuriant growth extract solution, 7.5 parts of propolis, 2 parts of solubilizer, 50 parts of ethanol, 1 part of anti-sensitizer and water.
3. mugwort mosquito repellant antipruritus toilet water according to claim 1 or 2, it is characterised in that the system of described P-Cymene
Preparation Method comprises the following steps：
S1, folium artemisiae argyi 200g is taken, crushed with pulverizer, load supercritical extraction unit；
S2, water-bath is opened, extraction equipment is reached 30 DEG C, be passed through CO2Air displacement in system is clean；
S3, pressure 20MPa in compressor regulation extractor is opened, regulation extractor outlet valve makes CO2Flow 15kg/h, keep
60min, open separator and take out extract, to be extracted to finish, close compressor, steel cylinder emptying CO2, produce.
4. mugwort mosquito repellant antipruritus toilet water according to claim 1 or 2, it is characterised in that described solubilizer is PEG-
40 rilanit specials.
5. mugwort mosquito repellant antipruritus toilet water according to claim 1 or 2, it is characterised in that described anti-sensitizer is by celestial being
Slap extract and mother chrysanthemum dimension element in mass ratio 2:3 compositions.
6. according to claim 5 contain mugwort mosquito repellant antipruritus toilet water, it is characterised in that described Radix et Caulis Opuntiae Dillenii extract
Preparation method comprise the following steps：
S1, weigh cactus 50g and crushed 80 mesh sieves and pour into reflux, it is 1 to add 600ml volume ratios:2 second alcohol and water
Mixed liquor flows back in 75 DEG C of water-bath and filters and collect filtrate I and filter residue after extraction 2h；
S2, by the filter residue that step S1 is obtained with 600ml volume ratios be 1:After 4 isopropanol and water mixed liquid ultrasonic extraction 15min
Filter and collect filtrate II, the filtrate I and II that suction filtration is obtained merge, and are concentrated and dried and produce.
7. the preparation method of the mugwort mosquito repellant antipruritus toilet water according to claim any one of 1-6, it is characterised in that including
Following steps：
S1, corresponding raw material is weighed by weight；
S2, by P-Cymene, Lavender, Rosemary Oil, oil of Cymbopogon winterianus, extract solution from aloe and solubilizer it is miscible after add
Ethanol and menthol, the lower water for adding dosage 50% is stirred, stir to obtain solution A；
S3, propolis is added in remaining water and is heated to 60-70 DEG C, stirred and be cooled to room temperature, obtain solution B；
S4, step S2 resulting solutions A and step S3 resulting solutions B be well mixed, add anti-sensitizer, produce.
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| CN108338951A (en) * | 2018-04-19 | 2018-07-31 | 厦门千鹰生物科技有限公司 | A kind of mosquito repellent, antipruritic, detumescence plant extraction liquid and its application |
| CN108686189A (en) * | 2018-08-08 | 2018-10-23 | 廖家平 | Removing miliaria and relieving itching Chinese medicine composition suitable for pregnant women and babies |
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| CN108686189A (en) * | 2018-08-08 | 2018-10-23 | 廖家平 | Removing miliaria and relieving itching Chinese medicine composition suitable for pregnant women and babies |
| CN109260054A (en) * | 2018-10-23 | 2019-01-25 | 广州艾蓓生物科技有限公司 | A kind of plant mosquito-repellent antipruritic cream and preparation method thereof |
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| CN109453094B (en) * | 2018-11-13 | 2021-07-06 | 广州艾蓓生物科技有限公司 | Mosquito-repelling and itching-relieving composition and skin care product containing composition |
| CN110251435A (en) * | 2019-07-24 | 2019-09-20 | 黑龙江省科学院高技术研究院 | A kind of essential oil with mosquito-expelling and antipruritic effect is spraying and preparation method thereof |
| CN110251435B (en) * | 2019-07-24 | 2022-01-11 | 黑龙江省科学院高技术研究院 | Essential oil spray with mosquito-repelling and itching-relieving effects and preparation method thereof |
| CN110420137A (en) * | 2019-08-26 | 2019-11-08 | 宁远瑞果生物科技有限公司 | A kind of camellia oil essence mosquito-repellent spray and preparation method thereof |
| CN111388372A (en) * | 2020-04-08 | 2020-07-10 | 名臣健康用品股份有限公司 | Plant composition for dispelling mosquitoes, cooling and relieving itching and preparation method thereof |
| CN111728895A (en) * | 2020-06-10 | 2020-10-02 | 周渡荣 | Plant essential oil emulsion for repelling mosquitoes, moistening skin and tendering skin and preparation method thereof |
| CN113143804A (en) * | 2021-04-28 | 2021-07-23 | 广州亦妆生物科技有限公司 | Plant composition and application thereof |
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