CN106943322A - A kind of mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract and preparation method thereof - Google Patents
A kind of mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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Abstract
The present invention relates to a kind of mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract and preparation method thereof, belong to daily chemical product field.The mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract that the present invention is provided includes following components and its percentage by weight：Folium Artemisiae Argyi extract 3.2 5.5%, peppermint oil 2.5 4%, oil of chamomile 2 4%, camellia seed oil 2 5%, extract solution from aloe 2.5 5%, octadecyl alcolol 4 8%, glycerine 6 10%, glycerin monostearate 3 5%, albolene 2 5%, preservative 0.3 0.7% and water 47.8 72.5%.The present invention passes through supercritical CO2Extraction molecule distillation combination carries out extraction separation to the functional component of folium artemisiae argyi, the mosquito-expelling and antipruritic cream prepared safety non-toxic, non-stimulated for human body；Have to the position crossed by bite by mosquitos anti-inflammatory, sterilizing, it is antipruritic the effects such as；This product is applied to skin surface simultaneously, can form one layer of special diaphragm, and the repellent effect for having uniqueness to mosquito, effect is rapid, and lasting medicine.
Description
Technical field
The invention belongs to field of daily chemicals, and in particular to a kind of mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract and its system
Preparation Method.
Background technology
When summer arrives, bite by mosquitos, which turns into, perplexs our a great problem, very itches once being bitten hard to bear, also holds
Easily trigger a variety of diseases such as dengue fever, malaria, have a strong impact on our work and life.Conventional mosquito repellent method has mosquito at present
Perfume, floral water, mosquito do not sting, mosquito repellent ring etc..Although this several method has certain repelling effect, igniting mosquito-repellent incense must be close
Close in space effectively, easily pollution environment easily makes one to produce allergic phenomena.
Chinese patent application CN103621581A discloses a kind of non-toxic mosquito-repellent incense, it be by realgar, camphor, folium artemisiae argyi,
Moschus, wrinkled giant hyssop, pearl powder, elm skin, oriental wormwood, peppermint, amber, cloves, the banksia rose, notopterygium root, the root of Dahurain angelica, radix bupleuri 5-10, calamus, rhizoma atractylodis,
Asarum peace is made according to weight proportion.The present invention have without any toxicity and side effects, beneficial health, qi-regulating of calming the nerves, wind resistance tremble with fear, control sense
Emit, prepare the advantages of facilitating.But igniting mosquito-repellent incense must be in confined space effectively, easy pollution environment makes one generation allergy and showed
As.
Chinese patent application CN106266189A discloses a kind of compound Asian puccoon mosquito-expelling and antipruritic cream and preparation method thereof, described
Compound Asian puccoon mosquito-expelling and antipruritic cream be made up of the raw material of following parts by weight：1-20 parts of Asian puccoon, 5-20 parts of honeysuckle, lilac 5-20
Part, 5-20 parts of folium artemisiae argyi, 5-20 parts of wrinkled giant hyssop, 5-20 parts of perilla leaf, 1-10 parts of Radix Angelicae Sinensis, windproof 1-10 parts, 1-10 parts of glutinous rehmannia, root of Dahurain angelica 1-
10 parts, 1-10 parts of dandelion, 1-10 parts of frankincense, 1-10 parts of myrrh, edible 40-60 parts of beeswax, 1-5 parts of borneol, sodium bicarbonate 1-5
Part, 0.1-1 parts of Peppermint essential oil, essential oil 0.1-1 parts yesterday, the invention component is various, complexity, to assort these components, just
Into certain difficulty, thus preparation cost is also very high, and its operating procedure is more numerous, it is necessary to one by one individually carry active ingredient
The making processing of medicament is carried out after taking again, thus seems not simple enough, for industrial scale production bring certain difficulty,
Efficiency is low.
The content of the invention
To solve the problems such as mosquito repellent product raw material present in prior art is complicated, product easily makes one to produce allergic phenomena,
The present invention provides a kind of mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract and preparation method thereof.
A kind of mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract of the present invention, includes following components and its percentage by weight：
Folium Artemisiae Argyi extract 3.2-5.5%, peppermint oil 2.5-4%, oil of chamomile 2-4%, camellia seed oil 2-5%, aloe carry
Take liquid 2.5-5%, octadecyl alcolol 4-8%, glycerine 6-10%, glycerin monostearate 3-5%, albolene 2-5%, preservative
0.3-0.7% and water 47.8-72.5%.
It is preferred that, the mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract is made up of following components and its percentage by weight：
Folium Artemisiae Argyi extract 4.35%, peppermint oil 3%, oil of chamomile 3%, camellia seed oil 3.5%, extract solution from aloe 3.5%,
Octadecyl alcolol 6%, glycerine 8%, glycerin monostearate 4%, albolene 3.5%, preservative 0.5% and water 60.65%.
It is preferred that, described preservative is Phenoxyethanol.
It is preferred that, the preparation method of described Folium Artemisiae Argyi extract comprises the following steps：
S1, supercritical CO2Extraction：The folium artemisiae argyi 5-10kg of natural drying is taken, is crushed with pulverizer, loads supercritical extract dress
Put；Water-bath is opened, extraction equipment is reached 30-50 DEG C, is passed through CO2, the air in system is replaced to clean, opening compressor,
Pressure reaches 12-18MPa in regulation extractor, adjusts extractor outlet valve, makes CO2Flow reaches 10-30kg/h, maintenance system
In this state 60-100min, separator is opened, extract is taken out, weighs, to be extracted to finish, close compressor, steel cylinder, emptying
CO2, obtain folium artemisiae argyi medicinal extract；
S2, molecular distillation：Molecular distillation apparatus is heated, when temperature reaches 100-120 DEG C, vacuum pumping is opened true
Sky, when vacuum reaches 600-800Pa, adds after the folium artemisiae argyi medicinal extract that above-mentioned steps S1 is obtained is heated into 50 DEG C from charging aperture
Enter, the rotating speed of regulation rotor knifing is 200-300r/min, obtains folium artemisiae argyi light component oil and folium artemisiae argyi restructuring respectively from two discharging openings
Divide oil, two are Folium Artemisiae Argyi extract.
In addition, the invention also discloses the preparation method of the mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract, comprising the following steps：
S1, get the raw materials ready：Corresponding raw material is weighed by weight；
S2, prepare ointment：Albolene and octadecyl alcolol is taken to be placed in beaker, 72-80 DEG C of bath temperature obtains its fusing
Fluid；Glycerin monostearate, G ＆ W are placed in another beaker, 72-80 DEG C of bath temperature, its dissolving is obtained water
Liquid；Aqueous is added in fluid, folium artemisiae argyi heavy constituent oil, peppermint oil, oil of chamomile, camellia seed oil, aloe are added in mixed liquor
Extract solution and preservative stir, when temperature is down to 45-50 DEG C, and stirring is lower to add folium artemisiae argyi light component oil；
S3, with ultraviolet lamp sterilization processing is carried out, be down to room temperature and produce.
It is preferred that, the preparation method of the mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract, prepare in step S2 aqueous and
The bath temperature of fluid is 76 DEG C.
Peppermint oil CAS：68917-18-0；Oil of chamomile CAS：8015-92-7；Extract solution from aloe CAS：85507-
69-3；Octadecyl alcolol CAS：112-92-5；Glycerine CAS：56-81-5；Glycerin monostearate CAS：123-94-4；Bai Fan
Intellectual circle No. CAS：8009-03-8；Phenoxyethanol CAS：122-99-6.
Folium artemisiae argyi is one of traditional Chinese medical science common medicine, is the dried leaf of feverfew Chinese mugwort, and its extract contains certain biocidal efficacies
Composition, certain biocidal efficacies composition is contained in it；Peppermint oil is colourless or flaxen supernatant liquid, there is special refrigerant fragrance；
Oil of chamomile is applied to face or body, can strengthen skin resistance, alleviates physical fatigue；Camellia seed oil has well to skin
Health-care effect, and camellia seed oil is the effects such as have disinfecting detoxifying and accelerating wound healing；Extract solution from aloe has anti-inflammatory and healing
The effect of wound, embedded biometric enzyme, by slowly being hydrolyzed with skin, plays anti-inflammation and sterilization effect, and under amino acid effect, with
Collagen acts on healing of wound in cuticula；Glycerine can be dissolved with water with arbitrary proportion, and have to skin good moisturizing and taste
Moisten effect；Glycerin monostearate is the emulsifying agent commonly used in cosmetics and medical paste, with good emulsifying effectiveness；Bai Fan
Intellectual circle has water proofing property, is a kind of extraordinary moisturizing articles for use, for preparing the ointment of medicine and the raw material of skin sparing ointment,
The chemical inertness of albolene causes it to any kind of skin all without excitant；Phenoxyethanol is that one kind is frequently used for shield
The organic compound of skin product, is colourless slightly band viscous liquid, has antibiotic effect, generally sent out in cosmetics, vaccine and medicine
Wave the function of preservative.
Compared with prior art, it is of the invention it is a technical advantage that：Pass through supercritical CO2Extraction-molecular distillation combination pair
The functional component of folium artemisiae argyi carries out extraction separation, the mosquito-expelling and antipruritic cream prepared safety non-toxic, non-stimulated for human body；It is right
The position crossed by bite by mosquitos have anti-inflammatory, sterilizing, it is antipruritic the effects such as；This product is applied to skin surface simultaneously, can form one layer
Special diaphragm, the repellent effect for having uniqueness to mosquito, effect is rapid, and lasting medicine.
Embodiment
The present invention is described in further details below by specific embodiment, these embodiments are only used for the mesh of illustration
, it is in no way intended to limit protection scope of the present invention.
Camellia seed oil is purchased from Fu'an City Bo Lin ecological agricultures Co., Ltd.
Embodiment 1-3, comparative example 1-2
The specific embodiment 1-3 and comparative example 1-2 of mosquito-expelling and antipruritic cream provided by the present invention group are listed in table 1 respectively
Into and raw material proportioning.
The embodiment 1-3 of table 1 and comparative example 1-2 components and raw material proportioning
The difference of comparative example 1 and embodiment 2 is：Without Folium Artemisiae Argyi extract, increase peppermint oil, oil of chamomile, camellia seed
The content of oil and extract solution from aloe.
The difference of comparative example 2 and embodiment 2 is：Without oil of chamomile, the content of increase peppermint oil and camellia seed oil.
The preparation method of mosquito-expelling and antipruritic cream of the embodiment 1 containing Folium Artemisiae Argyi extract：
S1, get the raw materials ready：Corresponding raw material is weighed by weight；
S2, prepare ointment：Albolene and octadecyl alcolol is taken to be placed in beaker, 72 DEG C of bath temperature makes its fusing obtain oil
Liquid；Glycerin monostearate, G ＆ W are placed in another beaker, 72 DEG C of bath temperature, its dissolving is obtained aqueous；By water
Liquid is added in fluid, added in mixed liquor folium artemisiae argyi heavy constituent oil, peppermint oil, oil of chamomile, camellia seed oil, extract solution from aloe and
Preservative stirs, when temperature is down to 45 DEG C, and stirring is lower to add folium artemisiae argyi light component oil；
S3, with ultraviolet lamp sterilization processing is carried out, be down to room temperature and produce.
The preparation method of mosquito-expelling and antipruritic cream of the embodiment 2 containing Folium Artemisiae Argyi extract：
S1, get the raw materials ready：Corresponding raw material is weighed by weight；
S2, prepare ointment：Albolene and octadecyl alcolol is taken to be placed in beaker, 76 DEG C of bath temperature makes its fusing obtain oil
Liquid；Glycerin monostearate, G ＆ W are placed in another beaker, 76 DEG C of bath temperature, its dissolving is obtained aqueous；By water
Liquid is added in fluid, added in mixed liquor folium artemisiae argyi heavy constituent oil, peppermint oil, oil of chamomile, camellia seed oil, extract solution from aloe and
Preservative stirs, when temperature is down to 47.5 DEG C, and stirring is lower to add folium artemisiae argyi light component oil；
S3, with ultraviolet lamp sterilization processing is carried out, be down to room temperature and produce.
The preparation method of mosquito-expelling and antipruritic cream of the embodiment 3 containing Folium Artemisiae Argyi extract：
S1, get the raw materials ready：Corresponding raw material is weighed by weight；
S2, prepare ointment：Albolene and octadecyl alcolol is taken to be placed in beaker, 80 DEG C of bath temperature makes its fusing obtain oil
Liquid；Glycerin monostearate, G ＆ W are placed in another beaker, 80 DEG C of bath temperature, its dissolving is obtained aqueous；By water
Liquid is added in fluid, added in mixed liquor folium artemisiae argyi heavy constituent oil, peppermint oil, oil of chamomile, camellia seed oil, extract solution from aloe and
Preservative stirs, when temperature is down to 50 DEG C, and stirring is lower to add folium artemisiae argyi light component oil；
S3, with ultraviolet lamp sterilization processing is carried out, be down to room temperature and produce.
The preparation method of comparative example 1-2 mosquito-expelling and antipruritic cream is similar to Example 2.
Properties of product evaluation test
1. the therapeutic action that the present invention is reacted mouse mosquito bite
Test material：Experimental animal is small white mouse, two kinds of sexes, body weight 28-35g；Aedes albopictus, it is wild, by laboratory
Propagating and breeding.
Test method：The ripe aedes albopictus of artificial propagation is placed in nylon yarn cylinder mould, cylinder mould size for it is long × wide ×
Food is not supplied in a height of 40cm × 30cm × 30cm, cage only for water.By mouse web portion unhairing, pairing two-by-two is fixed on cage outer wall, abdomen
Cage wall is close in unhairing position by portion, for bite by mosquitos.If 5 experimental groups, correspond to use embodiment 1-3 and comparative example 1-2 systems respectively
Standby mosquito-expelling and antipruritic cream.Each 10 small white mouses of experimental group, each experimental group applies prepared by embodiment 1-3 and comparative example 1-2 respectively
Mosquito-expelling and antipruritic cream (every small white mouse applies 0.1ml).After coating, put back in cage.All animals are put to death after two hours, belly table is pushed aside
Skin, calculates locus coeruleus area.Embodiment 1-3 and comparative example 1-2 mosquito-expelling and antipruritics cream mouse mosquito is stung after the therapeutic action such as institute of table 2
Show.
The mosquito-expelling and antipruritic cream of table 2 mouse mosquito is stung after therapeutic action
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 |
| Animal numbers/only | 10 | 10 | 10 | 10 | 10 |
| Average weight/g | 31.23 | 31.89 | 31.68 | 32.12 | 31.95 |
| Average spot dye area/mm2 | 13.20 | 11.02 | 12.85 | 16.23 | 15.31 |
As can be seen from Table 2, embodiment 1-3 spots dye area it is small compared with comparative example 1-2, it was demonstrated that the present invention in Folium Artemisiae Argyi extract and
The component compounding use such as peppermint oil, oil of chamomile, camellia seed oil, extract solution from aloe, has preferably to the reaction after bite by mosquitos
Therapeutic effect.Embodiment 2 is smaller compared with embodiment 1, the spot of embodiment 3 dye area, illustrates being preferable to carry out for the present invention of embodiment 2
Example.
2. laboratory test is determined
Attack is tested：In length × width × height to be put into 300 test worms in 40cm × 30cm × 30cm mosquito cage, people is tested
Member's arm exposure 4cm × 4cm skin areas, remainder tightly covers.Arm is stretched into 2min is placed in mosquito cage, record comes
Stop the mosquito number fallen,>30 persons are that attack is qualified, and the testing crew and its this cage mosquito can be used for repellency test.
Repellency test：The testing crew that attack is qualified is selected, 4cm × 4cm is respectively exposed on its both hands arm as described above
Skin area, wherein an arm is set to blank control, any smearing is not done；Another arm expose portion presses 1.5mg/
cm2Dose uniformity smear mosquito-expelling and antipruritic cream prepared by embodiment 1-3 and comparative example 1-2.Smear after 2h, arm is stretched into attack
2min in the qualified mosquito cage of power, observation, which whether there is mosquito, is come to suck blood, and is tested 1 time per 2h afterwards, as long as there is mosquito to come to suck blood i.e.
Sentence and fail.Effective protecting time (h) is recorded, a formula repeats experiment 10 times.
Effective Vate of Protection (%)=[(control group averagely stings thorn number-test group and averagely stings thorn number)/control group averagely stings thorn
Number] × 100, laboratory test results are as shown in table 3.
The repellency test data of table 3
As can be seen from Table 3, embodiment of the present invention 1-3 mosquito-expelling and antipruritics cream Effective Vate of Protection in 4h>80%, in 12h
Effective Vate of Protection>50%, and comparative example 1-2 mosquito-expelling and antipruritics cream Effective Vate of Protection in 4h<80%, the Effective Vate of Protection in 12h<
40%, illustrate that the component such as Folium Artemisiae Argyi extract and peppermint oil, oil of chamomile, camellia seed oil, extract solution from aloe compounding makes in the present invention
With with very good repellent worm effect, and embodiment 2 is higher compared with embodiment 1, the Effective Vate of Protection of embodiment 3, illustrates to implement
Example 2 is the preferred embodiments of the present invention.
3. field test is determined
Following with effect on probation for feeling the mosquito-expelling and antipruritic cream to evaluate embodiment 1-3 and comparative example 1-2 preparations.Using
Opinion poll point system, chooses the volunteer of 100 20-60 Sui age brackets as object on probation, is arbitrarily divided into 5 groups, respectively
The mosquito-expelling and antipruritic cream prepared with embodiment 1-3 and comparative example 1-2 is smeared by the arm of bite by mosquitos.Daily using twice, use
Time is 3 days.Every using effect total score is 5 points：5 points are best result, represent fine, very satisfied；4 points are preferable；3 points are
It can receive；Less than 3 points are bad, it is impossible to received.Every average is as shown in table 4.
The resultant effect of table 4 investigates score
| Using effect | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 |
| Repelling effect | 4.5 | 4.8 | 4.2 | 3.8 | 3.7 |
| It is nonirritant | 4.3 | 4.7 | 4.3 | 3.9 | 3.8 |
| Detumescence, antipruritic effect | 4.5 | 4.9 | 4.1 | 3.4 | 4.1 |
| Smell | 4.2 | 4.7 | 4.5 | 3.9 | 3.5 |
| Refrigerant sense | 4.3 | 4.8 | 4.6 | 4.2 | 3.9 |
As can be seen from Table 4, embodiment of the present invention 1-3 is higher compared with comparative example 1-2 scores, illustrates Folium Artemisiae Argyi extract of the present invention
With the component compounding use such as peppermint oil, oil of chamomile, camellia seed oil, extract solution from aloe, there are good refrigerant, mosquito repellent, detumescence, only
The effect itched, with rear repelling effect is obvious, excitant is small, antipruritic effect is obvious.Comprehensive items using effect, embodiment 2 is this
Invention preferred embodiment.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (6)
1. a kind of mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract, it is characterised in that include following components and its percentage by weight：
Folium Artemisiae Argyi extract 3.2-5.5%, peppermint oil 2.5-4%, oil of chamomile 2-4%, camellia seed oil 2-5%, extract solution from aloe
2.5-5%, octadecyl alcolol 4-8%, glycerine 6-10%, glycerin monostearate 3-5%, albolene 2-5%, preservative 0.3-
0.7% and water 47.8-72.5%.
2. the mosquito-expelling and antipruritic cream according to claim 1 containing Folium Artemisiae Argyi extract, it is characterised in that by following components and its
Percentage by weight is constituted：
Folium Artemisiae Argyi extract 4.35%, peppermint oil 3%, oil of chamomile 3%, camellia seed oil 3.5%, extract solution from aloe 3.5%, 18
Alcohol 6%, glycerine 8%, glycerin monostearate 4%, albolene 3.5%, preservative 0.5% and water 60.65%.
3. the mosquito-expelling and antipruritic cream according to claim 1 or 2 containing Folium Artemisiae Argyi extract, it is characterised in that described anti-corrosion
Agent is Phenoxyethanol.
4. the mosquito-expelling and antipruritic cream according to claim 1 or 2 containing Folium Artemisiae Argyi extract, it is characterised in that described folium artemisiae argyi
The preparation method of extract comprises the following steps：
S1, supercritical CO2Extraction：The folium artemisiae argyi 5-10kg of natural drying is taken, is crushed with pulverizer, loads supercritical extraction unit；Beat
Boiling water is bathed, and extraction equipment is reached 30-50 DEG C, is passed through CO2, the air in system is replaced to clean, opening compressor, regulation extraction
Take pressure in device to reach 12-18MPa, adjust extractor outlet valve, make CO2Flow reaches 10-30kg/h, and maintenance system is in this shape
State 60-100min, opens separator, takes out extract, weighs, and to be extracted to finish, close compressor, steel cylinder are vented CO2, obtain
To folium artemisiae argyi medicinal extract；
S2, molecular distillation：Molecular distillation apparatus is heated, when temperature reaches 100-120 DEG C, vavuum pump is opened and vacuumizes, when
When vacuum reaches 600-800Pa, the folium artemisiae argyi medicinal extract that above-mentioned steps S1 is obtained is heated to after 50 DEG C to add from charging aperture, regulation
The rotating speed of rotor knifing is 200-300r/min, obtains folium artemisiae argyi light component oil and folium artemisiae argyi heavy constituent oil, two respectively from two discharging openings
Item is Folium Artemisiae Argyi extract.
5. the preparation method of the mosquito-expelling and antipruritic cream containing Folium Artemisiae Argyi extract according to claim any one of 1-4, its feature
It is to comprise the following steps：
S1, get the raw materials ready：Corresponding raw material is weighed by weight；
S2, prepare ointment：Albolene and octadecyl alcolol is taken to be placed in beaker, 72-80 DEG C of bath temperature makes its fusing obtain oil
Liquid；Glycerin monostearate, G ＆ W are placed in another beaker, 72-80 DEG C of bath temperature, its dissolving is obtained aqueous；
Aqueous is added in fluid, folium artemisiae argyi heavy constituent oil, peppermint oil, oil of chamomile, camellia seed oil, aloe are added in mixed liquor and is extracted
Liquid and preservative stir, when temperature is down to 45-50 DEG C, and stirring is lower to add folium artemisiae argyi light component oil；
S3, with ultraviolet lamp sterilization processing is carried out, be down to room temperature and produce.
6. the preparation method of the mosquito-expelling and antipruritic cream according to claim 5 containing Folium Artemisiae Argyi extract, it is characterised in that step
The bath temperature that aqueous and fluid are prepared in S2 is 76 DEG C.
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