CN112618438B

CN112618438B - Mosquito repelling composition suitable for children and preparation method and application thereof

Info

Publication number: CN112618438B
Application number: CN202011627672.7A
Authority: CN
Inventors: 黄灯勇; 杨静妍
Original assignee: Lebi Guangzhou Health Industry Co ltd
Current assignee: Lebi Guangzhou Health Industry Co ltd
Priority date: 2020-12-31
Filing date: 2020-12-31
Publication date: 2022-02-15
Anticipated expiration: 2040-12-31
Also published as: CN112618438A

Abstract

A mosquito repellent composition suitable for children comprises the following components in parts by weight: 89.13-98.31 parts of a fluid characteristic regulator; 2.7-4.2 parts of a mosquito repellent; 1.97-3.55 parts of an antibacterial and anti-inflammatory soothing agent; 0.06-0.08 parts of a pH regulator; wherein the fluid characteristic regulator is a mixture of water, carbomer and methyl propylene glycol; the mosquito repellent comprises oleum Olivarum and menthanediol; the antibacterial and anti-inflammatory soothing agent is a mixture of water, propylene glycol, Glycyrrhrizae radix extract, radix Gentianae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, herba Artemisiae Annuae extract, biological carbohydrate gum-1, and tocopherol; the pH regulator is at least used for regulating the pH value of the composition. The mosquito repellent is achieved by utilizing various plant extracts with mosquito repellent effect, has the characteristics of safety and no toxicity, and is suitable for children. The mosquito control is realized on a plurality of layers, including mosquito repelling, mosquito bite relieving and the like.

Description

Mosquito repelling composition suitable for children and preparation method and application thereof

Technical Field

The invention relates to the field of daily necessities, in particular to a mosquito repellent composition suitable for children and a preparation method and application thereof.

Background

The mosquitoes can transmit various diseases such as malaria, dengue fever, Zika virus and the like, and the mosquitoes can interfere the normal life and physical and psychological health of people in the season. For example, in spring and summer, when the temperature is warmed up again, mosquitoes breed, the frequency of insect-bite dermatitis is obviously increased, papules, edematous erythema and other symptoms are often generated at the mosquito-bite part, the feeling of stabbing pain, extreme itching and the like in different degrees are accompanied, and great trouble is brought to the life of people. Moreover, the influence of mosquitoes is greater on infants, and because the infants have delicate skin, poor body immunity and sensitive and fragile, the allergic reaction after the mosquitoes bite is more obvious, the infants are slightly red and swollen after being bitten by the mosquitoes, and are seriously infected by bacteria, and even more, the infants can also cause encephalitis. Therefore, the mosquito repelling and bite preventing are very important for the normal life and health of people.

For a long time, the chemically synthesized insecticidal component has been the main position due to good effect and long duration of mosquito repelling and killing, but has some corresponding defects, such as: the long-term use of the mosquito repellent liquid can cause the mosquito to generate drug resistance and environmental pollution. For example, mosquito repellent components in the common electric mosquito repellent incense in the prior art are mainly DEET, although the mosquito repellent incense has good mosquito repellent effect, the long-term use of the mosquito repellent incense can cause environmental pollution, and the toxic and side effects are continuously reported, such as nervous system symptoms, skin damage, children encephalopathy, urticaria syndrome, low blood pressure, heart rate reduction and the like.

Therefore, a mosquito repelling product which has a good mosquito repelling effect, small toxic and side effects, safety and environmental friendliness is needed. At present, a plurality of plant essential oils have certain poisoning and repelling effects on mosquitoes, and the repelling mechanism is that the mosquitoes selectively avoid a signal source containing the plant essential oils or are repelled by the plant essential oils to reduce invasion to human beings, so that people are prevented from being disturbed by the mosquitoes, and the spread of insect-borne diseases is reduced. Because the main component is a plant extract, the plant extract is relatively more friendly to both human and environment. Therefore, it is a trend to use plant extracts as the effective ingredients of mosquito repellent products.

However, the existing related mosquito repellent preparations are often single and unstable in mosquito repellent components, and only adopt plant extracts, so that the effect is limited, and the mosquito repellent effect is not good. Meanwhile, in order to achieve a certain mosquito repelling effect, high mosquito repelling component content is often needed, toxic and side effects are still generated, or auxiliary materials of the mosquito repelling preparation have certain toxic and side effects and low safety, and the mosquito repelling preparation is often not suitable for children and can cause skin allergy, stress and other conditions. On the other hand, when the mosquitoes are more or the content of the used mosquito repellent is less, the mosquitoes cannot be avoided completely, and the traditional mosquito repellent does not consider the prevention and the control of the mosquitoes after approaching, such as: the relief of symptoms after mosquito bites and the like is not considered. Therefore, the prior art needs a mosquito repellent composition or related products which has stable properties, is safe, efficient and low in toxicity, is suitable for children, is not limited to repelling mosquitoes, and is more effective.

Disclosure of Invention

The invention aims to overcome at least one defect of the prior art, and provides a mosquito repelling composition suitable for children, a preparation method and an application thereof, which can be applied to mosquito repelling prevention and control to effectively repel mosquitoes, and the mosquito repelling composition or a corresponding product has high affinity to human skin, higher safety and no toxicity, is suitable for children, can relieve symptoms after mosquito bites, and improves adverse effects caused by surrounding or biting mosquitoes.

The invention adopts the technical scheme that a mosquito repellent composition suitable for children comprises the following components in parts by weight:

89.13-98.31 parts of a fluid characteristic regulator;

2.7-4.2 parts of a mosquito repellent;

1.97-3.55 parts of an antibacterial and anti-inflammatory soothing agent;

0.06-0.08 parts of a pH regulator;

wherein the fluid characteristic regulator is a mixture of water, carbomer and methyl propylene glycol; the mosquito repellent comprises oleum Olivarum and menthanediol; the antibacterial and anti-inflammatory soothing agent is a mixture of water, propylene glycol, Glycyrrhrizae radix extract, radix Gentianae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, herba Artemisiae Annuae extract, biological carbohydrate gum-1, and tocopherol; the pH regulator is at least used for regulating the pH value of the composition.

The fluid property modifier, which dominates the fluid property modification of the overall composition, the carbomer at least acting as a thickener; on the one hand, by adding a proper amount of carbomer, the viscosity of the composition can be reduced, and the stability of effective substances can be maintained. Meanwhile, carbomer is a natural medicinal component, has certain affinity to skin, is favorable for reducing irritation and damage of irritant substances to the skin after being added, has the functions of diminishing inflammation and sterilizing, and is favorable for relieving bitten parts. The methyl propylene glycol is present as a solvent, further facilitating the blending of the overall composition.

The mosquito repellent comprises balsam seed oil and menthanol; the oil of balsam pear has good permeability and sensitivity-relieving performance, is a natural mosquito repellent, and is beneficial to cooperating with other mosquito repellent components including menthanol so as to improve the mosquito repellent effect. The menthandiol is the only mosquito repellent from natural plant extracts in five mosquito repellents recommended by the United states EPA/CDC, is safe to human skin, has good mosquito repellent effect, and is a green environment-friendly mosquito repellent. However, in the prior art, the volatility of menthandiol is too high, the menthandiol cannot be kept for a long time, and the mosquito repellent effect is not obvious. The application utilizes the oil phase of the balsam seed oil to be mixed with the balsam seed oil, which is not only beneficial to leading the mosquito repellent to have the characteristics of relative independence and stability, but also can reduce the volatilization degree of the mosquito repellent, thereby prolonging the action time of the mosquito repellent. By using the combination of the oleum sophorae flavescentis and the menthandiol, compared with the prior art which adopts the menthandiol and other mosquito repellent preparations separately, the mosquito repellent composition can achieve a synergistic mosquito repellent effect.

The antibacterial and anti-inflammatory soothing agent is used for diminishing inflammation and soothing bitten parts, can effectively relieve itching and prevent bacterial infection, mainly comprises a licorice root extract, a gentian root extract, a sophora flavescens root extract, a cnidium fruit extract and a sweet wormwood herb extract as functional components, and has good effects of reducing skin itch and inhibiting inflammation by adopting a compound of various plant extracts. The licorice root extract has the functions of resisting inflammation and reducing oxidation speed, can prevent skin sensitivity phenomenon, and soothes allergic or irritated skin; the radix Gentianae extract has effect in relieving atopic dermatitis and allergy, resisting inflammation, and remarkably improving discomfort such as skin red swelling and itching. The extract of the sophora flavescens ait root has the functions of diminishing inflammation and resisting bacteria, killing parasites and relieving itching and has good relieving effect on skin itch. The cnidium fruit extract has good moisture keeping, antibacterial and antioxidant effects, and can protect irritated skin. The herba Artemisiae Annuae extract has antimalarial, antibacterial, antiviral, antiinflammatory, and analgesic effects; in the antibacterial and anti-inflammatory soothing agent, components with itching relieving and soothing effects are prepared by matching various traditional Chinese medicine plant extracts, so that the raw materials are natural, the drug dependence cannot be generated even after long-term use, and the safety can be guaranteed. The antibacterial anti-inflammatory soothing agent also comprises propylene glycol, and the propylene glycol is mixed with water, so that the hydrolysis of the effective components of the Chinese herbal medicines can be delayed, and the stability of the Chinese herbal medicines is enhanced.

The antibacterial anti-inflammatory soothing agent also comprises biological carbohydrate gum-1 and tocopherol, wherein the biological carbohydrate gum-1 can form a smooth moisturizing film on the surface of skin to smooth the skin, and the biological carbohydrate gum-1 can inhibit short-term inflammation and further improve the itching relieving and inflammation diminishing effects. The tocopherol, namely DL-alpha-tocopherol, has the effects of resisting oxidation, improving the stability and obviously reducing the acute skin reaction.

The invention distributes a plurality of components to form a plurality of relatively independent combinations, which is not only beneficial to the stability among the components, but also beneficial to the mutual cooperation to mutually promote the stability, the mosquito repellent effect, the antibacterial, anti-inflammatory and relieving effects of the components in the mosquito repellent composition. More importantly, compared with the traditional mosquito repellent adopting only a single mosquito repellent component in the prior art, the mosquito repellent agent not only uses various components to improve the mosquito repellent performance, but also is more convenient to realize the prevention and control of mosquitoes with multiple dimensions, including in the aspects of mosquito repelling and relieving itching. The main active ingredient is plant extract, the compatibility to human body is high, the safety and the non-toxicity are basically realized, and the health care tea is suitable for children.

Further, the fluid characteristic regulator comprises 86.05-92.19 parts of water, 0.08-0.12 part of carbomer and 3-6 parts of methyl propylene glycol.

Further, 3-10 parts of an anti-mosquito agent is also included, and the anti-mosquito agent is L-PDMS low-viscosity polydimethylsiloxane. The low viscosity polydimethylsiloxane is available from Shin-Etsu Chemical Co., Ltd. Some studies have shown that hydrophobic liquids can affect the movement of the legs and other extremities after a mosquito lands, in which case the mosquito can quickly escape the contact of the hydrophobic liquid. The existing mosquito repellent, especially the preparation with plant extract as the main mosquito repellent component, is usually based on the mosquito repellent principle, such as the mosquito repellent principle of covering up the lactic acid and other tastes on the skin surface of human body or emitting unpleasant odor of mosquitoes, and in the prevention and treatment of mosquito bite, the prevention and treatment can only be realized from the aspect of repelling mosquitoes. However, the mosquito repelling effect is often not only related to the type of the mosquito repelling component, but also closely related to the content of the mosquito repelling component, but as the content of the mosquito repelling component increases and the mosquito repelling effect increases, adverse reactions such as skin irritation and allergy inevitably occur, so that the improvement of the mosquito repelling effect and the reduction of the content of the mosquito repelling component are difficult to achieve simultaneously in the prior art. Therefore, the effect of repelling the mosquitoes by hundreds cannot be achieved, especially in the places with dense mosquitoes. At the moment, mosquitoes still need to stay on the surface of the skin before biting, and the application utilizes the L-PDMS to further provide the protection of the mosquito staying layer when the mosquitoes can not be repelled. Furthermore, in combination with mosquito repelling, antibacterial, anti-inflammatory relief, the mosquito repellent composition of the present invention actually achieves protection and treatment of all intermediate processes from approach of mosquitoes to mosquito bites. Therefore, the mosquito control of multiple layers can be realized by the mosquito repellent composition. Furthermore, the polydimethylsiloxane is not toxic to the skin, and the safety of the formed mosquito repellent composition can be ensured.

Furthermore, the antibacterial and anti-inflammatory soothing agent comprises 0.4 to 0.9 part of water, propylene glycol, licorice root extract, gentian root extract, sophora flavescens root extract, cnidium fruit extract and sweet wormwood herb extract, 1.5 to 2.5 parts of biogum saccharinum-1 and 0.07 to 0.15 part of tocopherol.

Further, the antibacterial, anti-inflammatory and soothing agent comprises water, propylene glycol, licorice root extract, gentian root extract, sophora flavescens root extract, cnidium fruit extract and artemisia apiacea extract in a ratio of 35: 60: 1: 1: 1: 1: 1. as described above, when water and propylene glycol are formulated in the stated ratio, it is helpful to slow down the hydrolysis of the extracts including licorice root extract, gentian root extract, sophora flavescens root extract, cnidium fruit extract, and artemisia apiacea extract, thereby prolonging the action time and the long-term use stability.

Further, the mosquito repellent comprises 0.4-0.8 part of emulsifier, 0.1-0.2 part of balsam seed oil, 1.6-2.3 parts of menthanediol, 0.3-0.7 part of p-hydroxyacetophenone and 0.3-0.9 part of 1, 2-hexanediol. The p-hydroxyacetophenone is a natural plant extract, is the safest high-temperature auxiliary activity stabilizer in the medical field at present, can improve the stability and prolong the lasting period through the p-hydroxyacetophenone, and can also prolong the storage life by utilizing the antiseptic effect of the p-hydroxyacetophenone.

Further, the emulsifier is a mixture of sorbitan olivate and cetearyl glucoside in a ratio of 1: 1. The sorbitan olive oleate belongs to a nonionic lipophilic emulsifier, and is added into the composition, so that the stability of the sorbitan olive oleate is not influenced by the polarity of the oil phase of the balsam seed oil and the content ratio of two phases, namely, the moisturizing type of the composition can be improved to improve the skin feeling, the original components are not adversely influenced, and the stability can be improved. Cetearyl glucoside, which is also part of the emulsifier, enhances the moisturizing effect of the composition and provides a good texture. The invention mixes the emulsifier containing sorbitan olivate and cetearyl glucoside with the balsam seed oil and the menthanol to be used as the mosquito repellent, so that the mosquito repellent components in the mosquito repellent have relatively independent stability and have corresponding mosquito repellent effect.

Further, the pH regulator is tromethamine. Because of the wide variety of components and the large variation in pH, pH adjusters are required for adjustment. The pH value is adjusted by adopting tromethamine, so that the whole system can be kept from being changed greatly, and a certain moisturizing effect is provided.

Further, the mosquito repellent composition suitable for children comprises the following components in parts by weight:

93.57 parts of fluid property regulator;

3.75 parts of a mosquito repellent;

2.6 parts of antibacterial and anti-inflammatory soothing agent;

0.07 part of a pH regulator;

further, the fluid characteristic regulator comprises 88.47 parts of water, 0.1 part of carbomer, 5 parts of methyl propylene glycol and 5 parts of trehalose by weight; the mosquito repellent comprises 0.5, 0.15, 2, 0.6 and 0.5 parts by weight of emulsifier, 0.15 part by weight of balsam seed oil, 0.6 part by weight of menthanol, 0.5 part by weight of p-hydroxyacetophenone and 0.5 part by weight of 1, 2 hexanediol, wherein the emulsifier is a mixture of sorbitan olivate and cetearyl glucoside, and the ratio of the sorbitan olivate to the cetearyl glucoside is 1: 1.

In one embodiment of the invention, the component formula is used for correspondingly forming a composition with better effect.

Another object of the present invention is to provide a method for preparing the mosquito repellent composition for children, comprising the steps of:

s1, respectively stirring the fluid characteristic regulator and the first mosquito repellent uniformly, heating to 80-85 ℃, mixing the fluid characteristic regulator and the first mosquito repellent, homogenizing and emulsifying for 5min, stirring and moisturizing for 20min, and cooling;

s2, cooling to 60 ℃, adding the antibacterial, anti-inflammatory and soothing agent material, and uniformly stirring;

and S3, continuously cooling to below 40 ℃, adding a pH regulator material, and slowly stirring to be uniform to obtain the mosquito-repellent spray composition.

It is a further object of the present invention to provide a mosquito repellent and/or soothing itch product comprising the above mosquito repellent composition suitable for children.

Compared with the prior art, the invention has the beneficial effects that: compared with a single mosquito repelling component, the mosquito repelling composition has the advantages that various plant extracts with mosquito repelling effects are utilized to achieve the mosquito repelling effect in a synergistic mode, the characteristics of safety and no toxicity are achieved, the skin of a human body is good, and the mosquito repelling composition is suitable for children. Meanwhile, a plurality of components are distributed to form a plurality of relatively independent combinations, so that not only is the stability among the components facilitated, but also the stability, the mosquito repellent effect, the antibacterial, anti-inflammatory and relieving effects of the components in the mosquito repellent composition are facilitated to be mutually promoted by the mutual matching. Compared with the traditional mosquito repellent which only adopts smell to repel mosquitoes on the repelling layer surface, the mosquito repellent realizes mosquito control on a plurality of layer surfaces, including mosquito repelling, mosquito bite relieving and the like. Meanwhile, the invention combines the cooperation of a plurality of compounds, can delay the hydrolysis of effective components, can promote the synergistic effect among different mosquito repellent components, and improves the stability and the aging durability of the whole mosquito repellent composition. The mosquito repellent composition can effectively prevent and treat mosquitoes and is used for a long time. Based on the corresponding mosquito repelling composition, the preparation method and the application, the mosquito repelling composition is beneficial to improving an effective, safe, non-toxic and lasting mosquito repelling mode and improving or avoiding adverse effects of mosquitoes on people at present.

Drawings

FIG. 1 is a flow chart of the production process of the present invention.

Detailed Description

The drawings are only for purposes of illustration and are not to be construed as limiting the invention. For a better understanding of the following embodiments, certain features of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.

Examples 1-3 mosquito repellent composition formulations (parts by weight); wherein the water, carbomer, and methyl propylene glycol form a fluid characteristic modifier; the mosquito repellent is formed by an emulsifier, balsam seed oil, menthanol, p-hydroxyacetophenone and 1, 2 hexanediol, and the ratio of sorbitan olivate to cetearyl glucoside in the emulsifier is 1: 1; the water, the propylene glycol, the licorice root extract, the gentian root extract, the sophora flavescens root extract, the cnidium fruit extract, the artemisia apiacea extract, the biogel-1 and the tocopherol form an antibacterial and anti-inflammatory soothing agent, and the proportion of the water, the propylene glycol, the licorice root extract, the gentian root extract, the sophora flavescens root extract, the cnidium fruit extract and the artemisia apiacea extract is 35: 60: 1: 1: 1: 1: 1; tromethamine is the pH regulator.

The preparation method comprises S1, respectively stirring fluid characteristic regulator and mosquito repellent uniformly, heating to 80-85 deg.C, mixing the fluid characteristic regulator and mosquito repellent, homogenizing and emulsifying for 5min, stirring, keeping moisture for 20min, cooling; s2, cooling to 60 ℃, adding the antibacterial, anti-inflammatory and soothing agent material, and uniformly stirring; s3, continuously cooling to below 40 ℃, adding a PH regulator material, and slowly stirring to be uniform to obtain the mosquito repellent composition.

The formula (parts by weight) of the mosquito repellent composition in the comparative examples 1 to 3 is the same as that in the examples 1 to 3.

Specifically, the mosquito repellent composition formula of the embodiment 4 to 6 is provided, and compared with the embodiment 1 to 3, the formula only correspondingly adds the L-PDMS with different weight parts. Compared with the preparation methods of the embodiments 1 to 3, the difference in the preparation method is that the L-PDMS is added after the antibacterial and anti-inflammatory soothing agent is uniformly stirred in the step S2.

Test one, skin irritation test

1. Test preparation: selecting 180 guinea pigs with similar weights, randomly dividing into 10 groups of 20 guinea pigs, and recording the groups as examples 1-6 and comparative examples 1-3; the guinea pigs were shaved 48h before the experiment with a range of 2cm x 2cm on the left and right sides of the back and marked.

2. Corresponding to the grouping of guinea pigs, 2ml of the corresponding experimental group sample was applied to one side of the naked skin of the guinea pig, and the other side was used as a blank control. After 3h of smearing, cleaning, and observing the local skin reaction of the tested part after 2h, 12h, 24h and 48h of cleaning.

3. Skin reaction scoring is carried out according to skin irritation test of 'cosmetic hygiene standard', comprehensive evaluation is carried out according to the average value of tested animal scores, and other toxic and side effects except irritation are observed.

4. And (3) test results: the highest integral mean value of each observation point of the groups 1-6 is less than 0.5, and the mosquito repellent is non-irritant and has no other toxic or side effect, which shows that the mosquito repellent preparation disclosed by the invention is mild in components and non-irritant to skin. In the comparative example, the guinea pigs in the group of comparative example 3 appeared partially reddened on the skin surface after 2 hours of washing and disappeared after 12 hours; no significant reaction was observed in the other comparative examples.

Test two, itching relieving and swelling diminishing test

1. Test preparation:

screening test persons and test insects according to GB/T13917.9-2009, and determining that the test persons have itching feeling and redness symptom of skin after being bitten by mosquitoes. Then, 100 testers meeting the qualification are selected to perform the itching relieving test. 100 testers are divided into groups of examples 1-6, groups of comparative examples 1-3 and blank control groups, 10 testers are in each group, the back of the hand of each tester is exposed to a test area of 5cm multiplied by 5cm, and the rest areas are strictly shielded. A tester puts hands into a mosquito cage, takes out the mosquito cage 10s after the mosquito bites, smears 2ml of samples of examples 1-6 and comparative examples 1-3 on a test area, records the itch relieving time and the detumescence time of skin, and calculates the average value of each group.

2. Test results

TABLE 1 antipruritic time and blister eliminating time

The above table shows that the mosquito repellent composition can well relieve itching and blistering of skin after mosquito bites, and has significant difference with a blank control group; the antibacterial and anti-inflammatory soothing agents in the group of the comparative example 3 are lower, and the itching relieving and blistering effects of the antibacterial and anti-inflammatory soothing agents are obviously different from those of the groups of the examples 1 to 6, which shows that the addition of the antibacterial and anti-inflammatory soothing agents improves the itching relieving and blistering effects of the system.

Third, testing mosquito-repellent effect

The mosquito repellent compositions of the groups of examples 1-6 and comparative examples 1-3 are tested according to the GB/T13917,9-2009 method

1. Attack force test

180 test insects are put in the mosquito cage, the back of the hand of a tester is exposed to the skin of 4cm multiplied by 4cm, and the rest part is tightly shielded. The hands are put into the mosquito cage for 2min, the mosquitoes are closely observed to stop falling, the arms are shaken to drive the mosquitoes away before the mouth organ of the mosquitoes penetrates into the skin, and the condition is recorded as that 1 test insect stops falling. More than 30 test persons who stop before and test insects are qualified in attack power, and the mosquitoes of the person and the cage can be subjected to a repelling test.

2. Repelling test

Selecting 100 testers (half of male and female) with qualified offensive power, exposing the test region with area of 4cm × 4cm on the back of both hands of the testers, and shielding the rest regions tightly, wherein one hand has a back of 0.5ml/cm²The test group was evenly smeared over the test area with the other hand as a blank control. Smearing for 2h, putting the hands into a mosquito cage with qualified attack power for 2min, observing whether mosquitoes come before and stop to suck blood, measuring every 1h, judging that the repellent product is invalid when one mosquito comes before to suck blood, and recording the effective protection time (h), wherein the results are shown in table 2.

TABLE 2 effective guard time (h)

Test example four, Long term stability test

The samples obtained in examples 1 to 3 and comparative examples 1 to 3 were taken 100ml each, and a long-term stability test was performed under different conditions shown in the following table, and the test results are shown in table 3 below.

TABLE 3 Long term stability test results

The preparation prepared in the embodiment 1-3 has excellent stability, and the solution still does not generate turbidity or precipitate after being stored for 12 months at 15 ℃ and 25 ℃, and does not have a layering phenomenon; the comparative example 2 is greatly different from the examples 1 to 3 in content, and stability tests show that the stability is insufficient, and the quality is easy to change with the passage of time. In contrast, in comparative examples 1 and 3, the contents of some components are difficult to be combined, which also causes quality changes such as delamination.

Test five, test and comparison of escape promoting effect after adding L-PDMS

100 test insects are put into the mosquito cage, the back of the hand of a tester is exposed to the skin of 40mm multiplied by 40mm, and the skin is smeared with 0.25ml of a sample of 1-6, so that the dosage is obviously reduced compared with other testing processes, the mosquito is convenient to stay close to the test cage, the effect of driving the L-PDMS away from the mosquito to escape after the mosquito stops is tested, and the rest part of the back of the hand is tightly shielded. And (3) stretching the hands into the mosquito cage to stay for 2 hours, closely observing to find that the mosquitoes stop falling, calculating the stay time of all the stopped mosquitoes within 2 hours, and calculating the average value.

TABLE 4 mosquito residence time

In the experimental results, the number of the mosquitoes staying in the examples 1 to 6 was 8 ± 3, and the mean value of the staying time of each group of mosquitoes was calculated. The results are shown in table 4, which indicates that L-PDMS can promote the escape of mosquitoes, so that mosquitoes can quickly escape from the skin surface of the subject coated with the mosquito repellent composition after staying.

Example 7

A preparation method of a safe and nontoxic mosquito repellent composition comprises the following steps:

s1, adding the fluid characteristic regulator (group A) material into a water pot, then stirring and heating to 80-85 ℃, adding the mosquito repellent material (group B) into an oil pot, and then stirring and heating to 80-85 ℃. Mixing the two phases, homogenizing and emulsifying for 5 minutes, stirring and moisturizing for 20 minutes, and cooling;

s2, cooling to 60 ℃, adding the antibacterial and anti-inflammatory soothing agent (group C) material, and uniformly stirring;

s3, continuously cooling to below 40 ℃, adding a PH regulator (group D), and slowly stirring until the mixture is uniform;

s4, taking materials, checking, filtering and discharging after the materials are qualified;

s5, standing: standing the material body for 12 hours after discharging;

s6, chemical examination: after discharging for 12 hours, sampling and testing;

s7, filling and code spraying: after the inspection is qualified, filling and code spraying are carried out;

s8, finished product: and after the qualified products are placed into a certificate, sealing the box and warehousing.

The equipment used comprises: a pure water processor, an electronic scale, an automatic emulsifying mixer, a steam heating generator, an ozone disinfection cabinet, an automatic filling machine, an electronic balance and a laser code spraying machine.

It should be understood that the above-mentioned embodiments of the present invention are only examples for clearly illustrating the technical solutions of the present invention, and are not intended to limit the specific embodiments of the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention claims should be included in the protection scope of the present invention claims.

Claims

1. The mosquito repellent composition suitable for children is characterized by comprising the following components in parts by weight:

the fluid characteristic regulator is a mixture of water, carbomer and methyl propylene glycol, wherein 86.05-92.19 parts of water, 0.08-0.12 part of carbomer and 3-6 parts of methyl propylene glycol are used as the fluid characteristic regulator;

the mosquito repellent comprises 0.4-0.8 part of emulsifier, 0.1-0.2 part of balsam seed oil, 1.6-2.3 parts of menthanediol, 0.3-0.7 part of p-hydroxyacetophenone and 0.3-0.9 part of 1, 2-hexanediol, wherein the emulsifier is a mixture of sorbitan olivate and cetearyl glucoside, and the ratio of sorbitan olivate to cetearyl glucoside is 1: 1;

the antibacterial and anti-inflammatory soothing agent is a mixture of water, propylene glycol, licorice root extract, gentian root extract, sophora flavescens ait root extract, cnidium fruit extract, sweet wormwood herb extract, biological carbohydrate gum-1 and tocopherol, wherein the total weight of the water, the propylene glycol, the licorice root extract, the gentian root extract, the sophora flavescens ait root extract, the cnidium fruit extract and the sweet wormwood herb extract is 0.4-0.9 part, the biological carbohydrate gum-1 is 1.5-2.5 parts, and the tocopherol is 0.07-0.15 part;

0.06-0.08 parts of pH regulator, wherein the pH regulator is at least used for regulating the pH value of the composition;

the mosquito repellent also comprises 3-10 parts of a mosquito repellent, wherein the mosquito repellent is low-viscosity polydimethylsiloxane.

2. A mosquito repellent composition for children according to claim 1, wherein the ratio of water, propylene glycol, licorice root extract, gentian root extract, sophora flavescens ait root extract, cnidium fruit extract and artemisia apiacea extract in the antibacterial, anti-inflammatory and soothing agent is 35: 60: 1: 1: 1: 1: 1.

3. a mosquito repellent composition for children according to claim 1, wherein the pH adjusting agent is tromethamine.

4. A mosquito repellent composition suitable for children according to any one of claims 1 to 3, which is characterized by comprising the following components in parts by weight:

the fluid characteristic regulator is a mixture of water, carbomer and methyl propylene glycol, wherein 88.47 parts of water, 0.1 part of carbomer and 5 parts of methyl propylene glycol are contained;

the mosquito repellent comprises 0.5 part of emulsifier, 0.15 part of balsam seed oil, 2 parts of menthanol, 0.6 part of p-hydroxyacetophenone and 0.5 part of 1, 2-hexanediol, wherein the emulsifier is a mixture of sorbitan olivate and cetearyl glucoside, and the ratio of the sorbitan olivate to the cetearyl glucoside is 1: 1;

the antibacterial and anti-inflammatory soothing agent is a mixture of water, propylene glycol, licorice root extract, gentian root extract, sophora flavescens ait root extract, cnidium fruit extract, sweet wormwood herb extract, biological carbohydrate gum-1 and tocopherol, wherein the total weight of the water, the propylene glycol, the licorice root extract, the gentian root extract, the sophora flavescens ait root extract, the cnidium fruit extract and the sweet wormwood herb extract is 0.5 part, the biological carbohydrate gum-1 is 2 parts and the tocopherol is 0.1 part;

0.07 part of pH regulator, wherein the pH regulator is tromethamine;

7 parts of an anti-mosquito agent, wherein the anti-mosquito agent is low-viscosity polydimethylsiloxane.

5. A method of preparing a mosquito repellent composition according to any one of claims 1 to 4 suitable for children comprising the steps of:

s1, respectively stirring the fluid characteristic regulator and the mosquito repellent uniformly, heating to 80-85 ℃, mixing the fluid characteristic regulator and the mosquito repellent, homogenizing and emulsifying for 5min, stirring and moisturizing for 20min, and cooling;

s2, cooling to 60 ℃, adding the antibacterial and anti-inflammatory soothing agent material, stirring uniformly, and adding the mosquito repellent low-viscosity polydimethylsiloxane;

s3, continuously cooling to below 40 ℃, adding a pH regulator material, and slowly stirring uniformly to obtain the mosquito-repellent spray composition.

6. A mosquito repellent and/or soothing itch product comprising the mosquito repellent composition for children of any one of claims 1 to 4.