CN111135209A

CN111135209A - Artemisia apiacea spray with effects of preventing malaria, repelling mosquitoes, relieving itching and repairing and preparation method thereof

Info

Publication number: CN111135209A
Application number: CN202010040838.9A
Authority: CN
Inventors: 江协辉
Original assignee: Xinyu Hao Hong Medical Technology Co Ltd
Current assignee: Xinyu Hao Hong Medical Technology Co Ltd
Priority date: 2020-01-15
Filing date: 2020-01-15
Publication date: 2020-05-12

Abstract

The invention relates to the technical field of mosquito repellent spray liquid, in particular to a sweet wormwood spray with functions of preventing malaria, repelling mosquitoes, relieving itching and repairing and a preparation method thereof. The sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing comprises the following preparation raw materials in percentage by mass: 30-60% of organic solvent, 1-3% of centella extract, 4-6% of sweet wormwood extract, 1-3% of lavender extract, 20-24% of mosquito repellent and itching relieving agent, 3-10% of antimalarial repairing agent, 2-8% of freshener, 1-2% of humectant and the balance of water. The sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing can quickly achieve the effects of relieving itching, diminishing swelling, repairing and preventing malaria. In addition, the sweet wormwood spray has special curative effect on skin diseases such as lupus erythematosus, skin herpes, tinea pedis and the like.

Description

Artemisia apiacea spray with effects of preventing malaria, repelling mosquitoes, relieving itching and repairing and preparation method thereof

Technical Field

The invention belongs to the technical field of antimalarial and mosquito-repellent spray, and particularly relates to a sweet wormwood spray with antimalarial, mosquito-repellent, itching-relieving and repairing functions and a preparation method thereof.

Background

When summer comes, mosquito bites become a big problem which troubles people, once the mosquito bites, red, swollen, wrapped and itching are things which are not normal, some people even have no specific reason for peculiar itching, the positions which are caught by the body are scars, yellow water and inflammation, particularly infants and children, the skin is very delicate, and the situation after the mosquito bites is more serious. The harm to people caused by mosquito bites is not only red, swollen, painful and itchy skin after being bitten and affects sleep, but also the most dangerous condition is that diseases can be transmitted. After mosquitoes bite people or livestock with pathogens, the mosquitoes become long-term storage hosts of the pathogens, and then the pathogens can be transmitted to healthy people when people bite the mosquitoes. Diseases such as malaria, filariasis, epidemic encephalitis B and dengue fever can be widely spread in the human population by mosquito bites. After a mosquito with plasmodium bites a human body, the human body is injected with the plasmodium, the disease can be caused after 10 to 20 days, the mosquito is mostly seen in south areas of Huaihe river in China, the clinical characteristics are intermittent chills, high fever and a large amount of sweating, the malaria is particularly prevalent in some areas of Africa, and the main transmission source of the areas is the mosquito. For people who are already bitten by mosquitoes, in order to prevent uncomfortable symptoms and disease transmission after the mosquitoes bite, the treatment of the bite wounds becomes more important, and a quick and effective medicine for relieving swelling and itching is needed.

For a long time, people have sought various methods to control mosquitoes. Some mosquito repellent products have good mosquito control effect and long duration, play a role in controlling mosquito-mediated diseases in many areas, and play an important role in daily life of people. The mosquito repellent product mainly comprises essential oil, a mosquito repellent bracelet, mosquito repellent toilet water and the like, the mosquito repellent toilet water is most popular mainly because the mosquito repellent toilet water can repel mosquitoes and remove body odor to emit fragrance, and the general mosquito repellent toilet water in the market is mainly prepared from chemical components such as alcohol, a synthetic mosquito repellent antipruritic, a humectant for delaying volatilization, essence and the like, and the synthetic mosquito repellent antipruritic is frequently used on the skin and can cause certain damage to the health of a human body. With the use of the organic synthetic insecticide in a large amount, the drug resistance of mosquitoes is stronger and stronger, so that the quantity of the mosquitoes is increased and decreased. In recent years, plant extracts such as artemisia oil, wild chrysanthemum, clove oil and the like are reported as mosquito-repellent antipruritic agents, but a single plant extract has short mosquito-repellent time, poor antipruritic effect and no effects of repairing and preventing malaria, so that the preparation which is safe to environment, safe to human body, easy to degrade and capable of repelling mosquitoes, preventing malaria and relieving itching is required to be paid attention.

Disclosure of Invention

In order to solve the problems, the invention provides a sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing, which comprises the following preparation raw materials in percentage by mass: 30-60% of organic solvent, 1-3% of centella extract, 4-6% of sweet wormwood extract, 1-3% of lavender extract, 20-24% of mosquito repellent and itching relieving agent, 3-10% of antimalarial repairing agent, 2-8% of freshener, 1-2% of humectant and the balance of water.

As a preferred technical scheme, the organic solvent is selected from one or more of isopropyl myristate, isopropyl palmitate, isopropyl linoleate, ethanol, liquid paraffin, ethyl acetate and fatty oil.

As a preferable technical scheme, the sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing also comprises a tribulus fruit extract as a raw material, wherein the mass ratio of the tribulus fruit extract to the centella asiatica extract is (1.2-2.8): 1.

as a preferable technical scheme, the mosquito-repellent antipruritic comprises a lemon eucalyptus leaf extract and a mint leaf extract.

As a preferable technical scheme, the mass ratio of the eucalyptus citriodora leaf extract to the mint leaf extract is (1-3): 1.

as a preferable technical scheme, the antimalarial repairing agent comprises elsholtzia extract, ampelopsis grossedentata leaf extract and bitter gourd extract.

As a preferable technical scheme, the mass ratio of the elsholtzia extract to the ampelopsis grossedentata leaf extract to the balsam pear extract is 1: (0.8-1.2): (0.3-0.6).

As a preferred technical solution, the cooling agent is selected from one or more of menthanol, citronellol, citronellal, eucalyptol and isopulegol.

As a preferred technical scheme, the humectant is selected from one or more of ectoin, propylene glycol, butylene glycol, glycerin, caprylic/capric triglyceride and sodium lactate.

The second aspect of the invention provides a sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing and a preparation method thereof, and the preparation method comprises the following steps: adding organic solvent and algefacient into a preparation pot, stirring uniformly at 40-50Hz, sequentially adding mosquito repellent and antipruritic agent and antimalarial repairing agent, stirring uniformly at 30-40Hz, adding water, stirring at 25-35Hz until the mixture is clear, adding herba Centellae extract, herba Artemisiae Annuae extract, Lavender extract, fructus Tribuli extract and humectant, stirring at 25-35Hz for 4-6min, filtering with 180-mesh filter cloth of 220 meshes, collecting filtrate, and bottling.

Has the advantages that: according to the sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing, the effective components of the sweet wormwood spray are fully exerted by selecting the solvent and the natural plant extract, the stable existence of the effective components in the plant extract is ensured, and the long-acting effects of the whole sweet wormwood spray, such as cooling, fragrance, relieving itching, repairing and preventing malaria, are further improved. The sweet wormwood spray is safe to human bodies, has no toxic or side effect after long-term use, and can play a good role in preventing mosquito bites and relieving itching no matter indoors or outdoors. The paint is sprayed to the bitten part in time after the bite, does not leave scars on the bitten part, and has good repairing effect. Meanwhile, the sweet wormwood spray has remarkable effects on preventing malaria infection and reducing malaria mortality, and particularly has remarkable special effects on malaria prevention. In addition, the sweet wormwood spray has special curative effect on skin diseases such as lupus erythematosus, skin herpes, tinea pedis and the like.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "including". As used herein, the terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase will render the claim closed except for the materials described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein in the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received by modifying or otherwise modifying such quantity without substantially changing the basic function to which it is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

Aiming at the technical problems, the invention provides a sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing, which comprises the following preparation raw materials in percentage by mass: 30-60% of organic solvent, 1-3% of centella extract, 4-6% of sweet wormwood extract, 1-3% of lavender extract, 20-24% of mosquito repellent and itching relieving agent, 3-10% of antimalarial repairing agent, 2-8% of freshener, 1-2% of humectant and the balance of water.

In a preferred embodiment, the invention provides a sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing, which comprises the following preparation raw materials in percentage by mass: 45% of organic solvent, 2% of centella asiatica extract, 5% of sweet wormwood extract, 2% of lavender extract, 22% of mosquito repellent and itching relieving agent, 6% of antimalarial repairing agent, 5% of cooling agent, 1% of humectant and the balance of water.

In a preferred embodiment, the sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing is prepared from raw materials which also comprise a tribulus fruit extract, wherein the mass ratio of the tribulus fruit extract to the centella asiatica extract is (1.2-2.8): 1.

in a preferred embodiment, the sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing is prepared from raw materials which also comprise a tribulus fruit extract, wherein the mass ratio of the tribulus fruit extract to the centella asiatica extract is 2: 1.

organic solvent

In one embodiment, the organic solvent is selected from one or more of isopropyl myristate, isopropyl palmitate, isopropyl linoleate, ethanol, liquid paraffin, ethyl acetate and fatty oil.

In a preferred embodiment, the organic solvent is ethanol, isopropyl myristate.

In a preferred embodiment, the mass ratio of ethanol to isopropyl myristate is 1: (0.3-0.5).

In a preferred embodiment, the mass ratio of ethanol to isopropyl myristate is 1: 0.4.

in a preferred embodiment, the viscosity of the ethanol is from 1.424 to 2.40 mpa.s.

In a more preferred embodiment, the viscosity of the ethanol is 1.424 mpa.s.

In a preferred embodiment, the isopropyl palmitate is purchased from guangzhou elevation chemical company, CAS number: 142-91-6, the viscosity of the isopropyl palmitate is 5-10 mPa.s; the ethanol was purchased from Anhuite Biochemical Co., Ltd.

The inventor finds that when the organic solvent is ethanol and isopropyl myristate through long-time research, the sweet wormwood spray has a good spraying effect and can cool and relieve itching for a long time. The possible reason is that if ethanol is used as a solvent alone, the volatilization of the ethanol can bring away the effective substances in the spray at the same time, accelerate the volatilization of the effective substances and cannot exert the drug effect durably, and if the ethanol and the isopropyl palmitate are mixed according to the mass ratio of 1: (0.3-0.5) when mixed, not only solves the problem that ethanol volatilizes and takes away effective substances, but also enhances the permeability of the effective substances, so that the effective substances can be kept for a long time, and the spraying agent can cool, scent and relieve itching for a long time, thereby further improving the repair function of the spraying agent.

Centella asiatica extract

The centella extract contains various triterpenes, the main components of the centella extract are asiaticoside and madecassoside, the asiaticoside is brown yellow to white fine powder in appearance, and the centella extract tastes slightly bitter. Has excellent effects on treating damp-heat jaundice, heatstroke diarrhea, sand stranguria with bloody stranguria, carbuncle, swelling, sore and traumatic injury. The centella asiatica extract can tighten the connecting part of the epidermis and the dermis, can soften the skin, is beneficial to solving the problem of skin relaxation, and enables the skin to be smooth and elastic; the collagen in the dermis is promoted to be formed, the fibrin is regenerated and is connected again, and the skin achieves the effects of tightening and smoothing. Can also help the injured tissue to heal and compact the skin. Can promote the close connection between the epidermis and the dermis, inhibit the increase of fat cells, and prevent skin edema and obesity.

Artemisia annua extract

The sweet wormwood extract is a substance extracted from sweet wormwood. Herba Artemisiae Annuae is the whole herb of Artemisia annua L of Compositae, and is named as herba Artemisiae Annuae, and herba Artemisiae Annuae. Is an annual herb, has a height of 1.5m, is yellow green and smelly. The stem is upright with longitudinal stripes and the upper part is branched. Withering basal and lower leaves in flowering period, middle leaves are oval, 4.5-7cm long, 2-3 plump deep cleft, and small lobe line shape with width of about 0.3mm, sharp tip, dark green surface, light back, no hair or slightly fine soft hair, and stalk; the upper leaves are gradually smaller without stalks. Most of head-shaped inflorescences are spherical, the diameter is about 2mm, and the head-shaped inflorescences are soft and short stalks and are arranged into a cone shape; 2-3 layers of involucre; the flower is tubular, the length of a female flower is about 0.5mm, the length of an amphoteric flower is about 1mm, and the flower is yellow; the tip of the anther is pointed and caudate, and the base is round and blunt; the column cap 2 is cracked, and the tip of the cracked piece is in the shape of a painting brush. The slim fruit is oval and about 0.6mm long. The flowering period is 8-10 months, and the fruit period is 10-11 months. It is produced in hillside, forest edge and wasteland all over the country. The sweet wormwood contains biological active substances such as anti-inflammatory substances, immunosuppression substances and the like, is used for Chinese herbal medicines in China, and can also be used for extracting spices; more importantly, the artemisinin can be separated from the sweet wormwood herb. The artemisinin is a sesquiterpene lactone compound with a peroxide bridge extracted and separated from artemisia apiacea leaves in 1971 by pharmaceutical workers in China, is an internationally recognized antimalarial specific drug which is autonomously developed in China, is a drug with the fastest effect, the best curative effect and the lowest toxicity in all antimalarial drugs known at present, has more prominent curative effect on cerebral malaria and chloroquine-resistant malignant malaria, and is more expensive, and the related drug resistance of the artemisinin drugs is not reported yet. In addition, the sweet wormwood herb extract has skin care activity on the skin of mammals, which has remarkable benefits of cornification promotion, pigmentation inhibition, scar formation inhibition, skin aging delay, skin elasticity maintenance, red swelling and hot pain elimination, skin demodex killing and the like.

Lavender extract

The lavender extract disclosed by the invention has activity against various bacteria, and linalool is an antibacterial main component of the lavender extract, can inhibit the growth of 17 bacteria and 10 fungi, and has certain antifungal activity. The lavender extracts 1% and 10% can inhibit conidium germination and spore growth of Botrytis cinerea, and inhibit spore growth more effectively than hyphae. Its action is through raising intracellular cyclic adenosine monophosphate level and work.

Extract of fructus Tribuli

The tribulus fruit extract is extracted from tribulus fruit and contains abundant chemical components such as tribulus polysaccharide, alkaloid, flavone, amino acid, steroid saponin and the like, and the tribulus saponin in the tribulus fruit extract has the effects of reducing blood pressure, reducing blood fat, resisting arteriosclerosis, inhibiting bacteria, resisting aging and strengthening. The peroxide catabolic enzyme contained in the composition has obvious anti-aging effect and can improve the immunity of the human body.

The inventor finds that the fructus tribuli extract is added into the sweet wormwood spray to obviously improve the lasting cooling, refreshing, fragrance-releasing, bacteriostatic, itching-relieving and repairing functions. The possible reason is that the combination of the tribulus fruit extract and the artemisia apiacea extract can maintain a neutral environment, so that the stability of triterpenoid saponin serving as an effective component in the centella asiatica extract is ensured, and the effective component in the lavender extract is stabilized, so that the long-term cooling, refreshing and repairing functions are realized. In addition, the steroid saponin and the polysaccharide substance in the tribulus fruit extract can ensure the stable release of the effective substances in the artemisia apiacea extract, and the steroid saponin and the triterpenoid saponin have the synergistic effect, so that the artemisia apiacea spray has obvious bacteriostatic effect and repair function.

Mosquito-repellent antipruritic

The mosquito-repellent antipruritic agent is selected from a pure natural plant source, and no preservative or essence is added; the mosquito repellent effect is obvious, and the repellent time is equivalent to that of deet; has broad-spectrum repellent effect; the common pathogenic bacteria carried by mosquitoes are effectively inhibited; safe, mild and non-irritating.

In one embodiment, the mosquito repellent antipruritic comprises an extract of eucalyptus citriodora leaves, an extract of mint leaves.

The Eucalyptus citriodora leaf extract is a substance extracted from the leaves of Eucalyptus citriodora. Eucalyptus citriodora is an evergreen big tree, an important fast-growing tree species and a good aromatic oil tree species in the south. It is rich in aromatic substances. Dried leaves are oblong (young leaves) or ovoid in shape (old leaves) and yellow-green. The upper surface of the young leaves and the petioles have brown stabbing hair, more spots of the wood plugs are rough, and the fragrance is stronger. The old leaves are smooth and hairless, and the fragrance is slightly inferior to that of the young leaves. Contains volatile oil 0.5-2.0%, wherein the main ingredients are citronellal, citronellol, geraniol, isopulegol, 1, 8-cineole and guaiol. It also contains rutin, quercitrin, quercetin, shikimic acid, quinic acid, glutaric acid, succinic acid, malic acid, citric acid and eucalyptol, and may be derivatives of coumarin, and has high astringency, and can be used for dispelling pathogenic wind, removing dampness, and treating malaria, rubella, eczema, intractable tinea, scald due to hot water and fire, and bullet wound.

The mint leaf extract contains components such as mint oil, menthol, menthone, isomenthone, rosmarinic acid and the like, has specific cool and fragrant smell, and has desensitizing, anti-inflammatory and antibacterial effects on bitten skin. Menthol in the mint leaf extract has a strong bactericidal effect, and D-menthol has a stronger bacteriostatic effect than L-menthol.

In a preferred embodiment, the mass ratio of the eucalyptus citriodora leaf extract to the mint leaf extract is (1-3): 1.

in a more preferred embodiment, the mass ratio of the eucalyptus citriodora leaf extract to the mint leaf extract is 2: 1.

antimalarial repairing agent

The antimalarial repairing agent is a plant extract with antimalarial, detumescence and repairing effects.

In one embodiment, the antimalarial restoration agent comprises elsholtzia extract, ampelopsis grossedentata leaf extract, and momordica charantia extract.

The elsholtzia extract is extracted from elsholtzia splendens which is a plant of the genus camelina of the family labiatae. Standing herbaceous plants. The stem is 9-40 cm high, slender, multi-branched from the base, or the plant is short and not branched, and is white, fluffy and soft. Leaf-line-shaped oblong to line-shaped lanceolate.

The Ampelopsis grossedentata leaf extract is a substance extracted from the leaves of Ampelopsis grossedentata of the genus Ampelopsis of the family Vitaceae.

The balsam pear extract contains steroid saponin such as momordicin, and can regulate various viral diseases in tropical regions.

In a preferred embodiment, the mass ratio of the elsholtzia extract to the ampelopsis grossedentata leaf extract to the momordica charantia extract is 1: (0.8-1.2): (0.3-0.6).

In a more preferred embodiment, the mass ratio of the elsholtzia extract to the ampelopsis grossedentata leaf extract to the momordica charantia extract is 1: 1: 0.5.

in a most preferred embodiment, the antimalarial restoration agent is microencapsulated.

The preparation method of the antimalarial restoration agent comprises the following steps:

weighing chitosan and hyperbranched polyamide compound, dissolving in distilled water, adding herba Moslae extract, Ampelopsis grossedentata leaf extract and fructus Momordicae Charantiae extract at room temperature after completely dissolving, stirring, ultrasonic treating for 30min, mixing, and emulsifying and spray drying.

The mass of the balsam pear extract is 50% of that of the chitosan and hyperbranched polyamide compound.

The preparation method of the chitosan and hyperbranched polyamide compound comprises the following steps:

1g of dodecanedioic acid is dissolved in 4mL of dimethyl sulfoxide to obtain a dodecanedioic acid solution; dissolving 3g of chitosan in 10mL of dimethyl sulfoxide to obtain a chitosan solution; dissolving 3g of hyperbranched polyamide in 10mL of dimethyl sulfoxide to obtain a hyperbranched polyamide solution; adding the dodecanedioic acid solution into a reaction kettle, stirring, keeping the temperature at 50 ℃, then adding the chitosan solution, reacting for 3 hours, and cooling to obtain dodecanedioic acid modified chitosan; and adding a hyperbranched polyamide solution into the dodecanedioic acid modified chitosan, continuously reacting for 2 hours at 60 ℃, cooling, washing and drying to obtain the chitosan and hyperbranched polyamide compound.

The inventor finds that the antimalarial repairing agent prepared into the microcapsule can obviously improve the antimalarial repairing effect. On one hand, the possible reasons are that the beneficial components of the elsholtzia extract, the ampelopsis grossedentata leaf extract and the balsam pear extract play a better role in coordination, and particularly have excellent antimalarial repairing effect on the skin after being bitten by mosquitoes; on the other hand, the invention adopts a unique microcapsule structure, wherein chitosan and hyperbranched polyamide are connected through dodecanedioic acid, in the wall material structure, the chitosan is a first wall material, the spherical hyperbranched polyamide is a second wall material, and the second wall material tightly surrounds the outer side of the first wall material.

Cooling agent

The cooling agent provided by the invention is a substance with a cooling effect on human skin.

In one embodiment, the cooling agent is selected from one or more of menthanol, citronellol, citronellal, eucalyptol, and isopulegol.

In a preferred embodiment, the cooling agent is a mixture of menthanediol and citronellol.

In a preferred embodiment, the weight ratio of the menthanol to the citronellol is 1: (1.3-2.1).

In a preferred embodiment, the weight ratio of the menthanol to the citronellol is 1: 1.7.

in a most preferred embodiment, the citronellol is β -citronellol.

Moisture-retaining agent

The moisturizer is a cosmetic raw material with the functions of moisturizing and repairing sebum membranes, and the raw material has a special molecular structure, can adsorb and retain moisture, and maintains the skin barrier function while maintaining the skin hydration.

In one embodiment, the humectant is selected from one or more of ectoin, propylene glycol, butylene glycol, glycerin, caprylic/capric triglyceride, sodium lactate.

In a preferred embodiment, the humectant is ectoin and caprylic/capric triglyceride.

In a preferred embodiment, the mass ratio of ectoin to caprylic/capric triglyceride is 1: (0.3-1.2).

In a preferred embodiment, the mass ratio of ectoin to caprylic/capric triglyceride is 1: 0.8.

in one embodiment, the ectoin is purchased from Huaxi Biotech, Inc.

Examples

In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the starting materials and plant extracts used are commercially available, unless otherwise specified.

Example 1

Embodiment 1 provides a sweet wormwood spray with effects of preventing malaria, repelling mosquitoes, relieving itching and repairing, which comprises the following preparation raw materials in percentage by mass: 45% of organic solvent, 2% of centella asiatica extract, 5% of sweet wormwood extract, 2% of lavender extract, 4% of tribulus fruit extract, 22% of mosquito repellent and itching relieving agent, 6% of antimalarial repairing agent, 5% of freshener, 1% of humectant and the balance of water.

The organic solvent is ethanol and isopropyl myristate.

The mass ratio of the ethanol to the isopropyl myristate is 1: 0.4.

the viscosity of the ethanol was 1.424 mpa.s.

The mosquito repellent and antipruritic agent comprises Eucalyptus citriodora leaf extract and folium Menthae extract.

The mass ratio of the eucalyptus citriodora leaf extract to the mint leaf extract is 2: 1.

the antimalarial repairing agent comprises herba Moslae extract, Ampelopsis grossedentata leaf extract, and fructus Momordicae Charantiae extract.

The mass ratio of the elsholtzia extract to the ampelopsis grossedentata leaf extract to the bitter gourd extract is 1: 1: 0.5.

the antimalarial restoration agent is microcapsule.

The preparation method of the antimalarial restoration agent comprises the following steps: weighing chitosan and hyperbranched polyamide compound, dissolving in distilled water, adding herba Moslae extract, Ampelopsis grossedentata leaf extract and fructus Momordicae Charantiae extract at room temperature after completely dissolving, stirring, ultrasonic treating for 30min, mixing, and emulsifying and spray drying.

The cooling agent is a mixture of menthanol and citronellol.

The mass ratio of the menthanol to the citronellol is 1: 1.7.

the citronellol is β -citronellol.

The humectant is ectoin and caprylic/capric triglyceride.

The mass ratio of the ectoin to the caprylic/capric triglyceride is 1: 0.8.

the preparation method of the sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing comprises the following steps: adding organic solvent and algefacient into a preparation pot, stirring uniformly at 45Hz, sequentially adding mosquito repellent antipruritic and antimalarial repairing agent, stirring uniformly at 35Hz, adding water, stirring to clarify at 30Hz, adding herba Centellae extract, herba Artemisiae Annuae extract, Lavender extract, fructus Tribuli extract, and humectant, stirring at 30Hz for 5min, filtering with 200 mesh filter cloth, collecting filtrate, and bottling.

Example 2

The embodiment 2 is basically the same as the embodiment 1, and is different from the embodiment 1 only in that the sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing comprises the following preparation raw materials in percentage by mass: 60% of organic solvent, 1% of centella extract, 4% of sweet wormwood extract, 1% of lavender extract, 1.2% of tribulus fruit extract, 20% of mosquito repellent and itching relieving agent, 3% of antimalarial repairing agent, 2% of algefacient, 1% of humectant and the balance of water.

Example 3

The embodiment 3 is basically the same as the embodiment 1, and is different from the embodiment 1 only in that the sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing comprises the following preparation raw materials in percentage by mass: 30% of organic solvent, 3% of centella asiatica extract, 6% of sweet wormwood extract, 3% of lavender extract, 7% of tribulus fruit extract, 24% of mosquito repellent and itching relieving agent, 10% of antimalarial repairing agent, 8% of freshener, 2% of humectant and the balance of water.

Comparative example 1

Comparative example 1 is essentially the same as example 1 except that the organic solvent is ethanol.

Comparative example 2

Comparative example 2 is essentially the same as example 1 except that the organic solvent is isopropyl myristate.

Comparative example 3

The comparative example 3 is basically the same as the example 1, and is different in that the sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing comprises the following preparation raw materials in percentage by mass: 45% of organic solvent, 2% of centella asiatica extract, 5% of sweet wormwood extract, 2% of lavender extract, 22% of mosquito repellent and itching relieving agent, 6% of antimalarial repairing agent, 5% of cooling agent, 1% of humectant and the balance of water.

Comparative example 4

The comparative example 4 is basically the same as the example 1, and is different in that the sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing comprises the following preparation raw materials in percentage by mass: 45% of organic solvent, 0.2% of centella asiatica extract, 5% of sweet wormwood extract, 2% of lavender extract, 2% of tribulus fruit extract, 22% of mosquito repellent and itching relieving agent, 6% of antimalarial repairing agent, 5% of freshener, 1% of humectant and the balance of water.

Comparative example 5

The comparative example 5 is basically the same as the example 1, and is different from the example 1 in that the sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing comprises the following preparation raw materials in percentage by mass: 45% of organic solvent, 2% of centella asiatica extract, 5% of sweet wormwood extract, 2% of lavender extract, 0.2% of tribulus fruit extract, 22% of mosquito repellent and itching relieving agent, 6% of antimalarial repairing agent, 5% of freshener, 1% of humectant and the balance of water.

Comparative example 6

Comparative example 6 is essentially the same as example 1 except that the antimalarial restoration agent is a conventional composition.

Comparative example 7

Comparative example 7 is essentially the same as example 1 except that the humectant is ectoin.

The foregoing examples are merely illustrative and are provided to illustrate some of the features of the present disclosure. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. And that advances in science and technology will result in possible equivalents or sub-substitutes not currently contemplated for reasons of inaccuracy in language representation, and such changes should also be construed where possible to be covered by the appended claims.

Evaluation of Performance

1. The sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing, prepared by the invention, reaches the national repellent standard (GB/T13917.9-2009).

2, trial experience: 10 volunteers (the ages are 3-45 years old) are selected, the sweet wormwood spray prepared in the example 1 and having the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing is used, and the product is evaluated after the use. After the skin-care agent is used, volunteers generally feel good in itching relieving effect, cool and comfortable in skin feeling, and have repairing effect. The specific results are as follows:

TABLE 1. use evaluation of the spray of Artemisia annua prepared in example 1

Volunteers 4 also used the spray of artemisia apiacea of comparative examples 1-2, and the results are shown in the following table:

TABLE 2 evaluation of volunteers 4 using the spray of Artemisia annua prepared in comparative examples 1-2

Item	State after using sweet wormwood spray
		Comparative example 1	No cool and refreshing feeling, sleep sound, no mosquito bite mark after 3-4h
Comparative example 2	Lasting cool and refreshing fragrance, and a little bit sticky feeling (but clear and refreshing) when being sprayed and smeared

Volunteers 6 also used the spray of artemisia apiacea of comparative examples 3-5, and the results are shown in the following table:

TABLE 3 evaluation of volunteers 6 using the spray of Artemisia annua prepared in comparative examples 3-5

Item	State after using sweet wormwood spray
		Comparative example 3	The bubbles can disappear after being sprayed for 2 to 3 days
Comparative example 4	The ink can disappear after being sprayed for 6-8 hours and has red marks which last for about 1 day
		Comparative example 5	The bubbles can disappear after being sprayed for 1 day

Wherein volunteer 7 also used the spray of artemisia apiacea of comparative example 6, the results are given in the following table:

TABLE 4 evaluation of the use of the spray of Artemisia annua prepared in comparative example 6 by volunteer 7

Item	State after using sweet wormwood spray
		Comparative example 6	After being continuously used for 1 month, the itching relieving and bacteriostatic effects are obvious

Wherein volunteer 9 also used the spray of artemisia apiacea of comparative example 7, the results are given in the following table:

TABLE 5 evaluation of volunteers 9 Using the spray of Artemisia annua prepared in comparative example 7

Item	State after using sweet wormwood spray
		Comparative example 7	The big bag disappears about 1 day after spraying, and the itching is relieved immediately after spraying

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. The sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing is characterized by comprising the following preparation raw materials in percentage by mass: 30-60% of organic solvent, 1-3% of centella extract, 4-6% of sweet wormwood extract, 1-3% of lavender extract, 20-24% of mosquito repellent and itching relieving agent, 3-10% of antimalarial repairing agent, 2-8% of freshener, 1-2% of humectant and the balance of water.

2. The sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing according to claim 1, wherein the organic solvent is one or more selected from isopropyl myristate, isopropyl palmitate, isopropyl linoleate, ethanol, liquid paraffin, ethyl acetate and fatty oil.

3. The sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing according to claim 1 is characterized in that the sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing is prepared from raw materials which also comprise a tribulus fruit extract, wherein the mass ratio of the tribulus fruit extract to the centella asiatica extract is (1.2-2.8): 1.

4. the sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing according to claim 1, wherein the mosquito-repelling itching-relieving agent comprises a eucalyptus citriodora leaf extract and a mint leaf extract.

5. The sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing according to claim 4, wherein the mass ratio of the eucalyptus citriodora leaf extract to the mint leaf extract is (1-3): 1.

6. the spray of sweet wormwood herb with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing according to claim 1, wherein the antimalarial repairing agent comprises an elsholtzia extract, a ampelopsis grossedentata leaf extract and a bitter gourd extract.

7. The sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing according to claim 6, wherein the mass ratio of the elsholtzia extract to the ampelopsis grossedentata leaf extract to the bitter gourd extract is 1: (0.8-1.2): (0.3-0.6).

8. The sweet wormwood spray with the effects of preventing malaria, repelling mosquitoes, relieving itching and repairing according to claim 1, wherein the cooling agent is selected from one or more of menthanol, citronellol, citronellal, eucalyptol and isopulegol.

9. The spray of sweet wormwood to prevent malaria, repel mosquitoes, relieve itching and repair according to claim 1, wherein the humectant is selected from one or more of ectoin, propylene glycol, butylene glycol, glycerin, caprylic/capric triglyceride, sodium lactate.

10. A method for preparing the sweet wormwood spray with the functions of preventing malaria, repelling mosquitoes, relieving itching and repairing according to any one of claims 2 to 9, which is characterized by comprising the following steps: adding organic solvent and algefacient into a preparation pot, stirring uniformly at 40-50Hz, sequentially adding mosquito repellent and antipruritic agent and antimalarial repairing agent, stirring uniformly at 30-40Hz, adding water, stirring at 25-35Hz until the mixture is clear, adding herba Centellae extract, herba Artemisiae Annuae extract, Lavender extract, fructus Tribuli extract and humectant, stirring at 25-35Hz for 4-6min, filtering with 180-mesh filter cloth of 220 meshes, collecting filtrate, and bottling.