CN115869197A - Bacteriostatic itching-relieving agent - Google Patents
Bacteriostatic itching-relieving agent Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a bacteriostatic antipruritic, which comprises 45-55 parts of eucalyptus citriodora leaf extract, 15-20 parts of aloe extract, 10-15 parts of turpentine oil extract, 7-12 parts of sulfur, 10-15 parts of dandelion extract and 10-15 parts of citric acid. The invention adopts the compound essential oil to achieve the effect of synergy, increase the mosquito-repelling and bacteriostatic effects and achieve the effects of relieving itching and relieving, and the effects are achieved by combining the medicines.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to a bacteriostatic itching-relieving agent.
Background
The skin itch belongs to neuropsychiatric dermatosis, and is a skin neurosis disease. The skin itch can scratch the itchy part of a patient, so that scars appear on the skin, the beauty is affected, people are worried, and the repeated scratching can cause viral or bacterial infection at the wound, so that the health of people is affected. The long-term skin itch also causes people to be inattentive and brings negative effects on sleep and emotion, so that skin diseases such as the skin itch are gradually attracted to people for more and more attention and research.
The causes of skin itching can be broadly divided into two, an internal cause, which mainly involves stress and an increase in skin temperature, and an external cause, which mainly involves climate change and fungal or bacterial infection. At present, the pathogenesis of the skin pruritus is still unclear, the treatment of the skin pruritus is more difficult due to various pathogenesis reasons, and the individual difference of diseases also makes doctors have no help in the treatment of the skin pruritus.
Disclosure of Invention
The invention provides a bacteriostatic itching-relieving agent for solving the defects in the prior art.
In order to solve the technical problems, the invention adopts the following technical scheme: an antibacterial antipruritic comprises 45-55 parts of Eucalyptus citriodora leaf extract, 15-20 parts of aloe extract, 10-15 parts of turpentine oil extract, 7-12 parts of sulfur, 10-15 parts of dandelion extract and 10-15 parts of citric acid.
The dandelion is an alkaline substance, is rich in vitamins and minerals, is cheap, has the effects of cooling and clearing heat and is rich in vitamin B2, the sulfur has special smell, can be used for repelling mosquitoes and is harmless to a human body, the growth of microorganisms such as bacteria and the like can be inhibited under an acidic condition, the citric acid is an acidic substance, the alkalinity of the dandelion can be neutralized, so that the antipruritic agent is acidic, and the citric acid has certain hygroscopicity besides the acidic characteristic, can accelerate the body metabolism, promotes the renewal of skin cutin, can whiten the skin while being harmless to the human body, is cheap and has low cost;
preferably, the raw materials comprise 51 parts of eucalyptus citriodora leaf extract, 17 parts of aloe extract, 11 parts of turpentine oil extract, 10 parts of sulfur, 13 parts of dandelion extract and 13 parts of citric acid.
Preferably, the preparation method of the bacteriostatic antipruritic comprises the following steps:
s1, adding a eucalyptus citriodora leaf extract and an aloe extract into a reactor at normal temperature and normal pressure, stirring under the condition of ultrasonic frequency of 30-40kHz, and stirring and mixing to obtain an extraction mixture;
s2, slowly dripping 45% of dandelion extract and 65% of turpentine extract into the extraction mixture, slowly stirring to obtain a mixed solution A, slowly dripping citric acid into the mixed solution A, adjusting the pH value to 7, and stopping adding the citric acid to obtain a mixed solution B;
s3, adding sulfur into the mixed solution B, stirring for 30-35min, then adding the rest dandelion extract and the rest turpentine oil extract, and slowly stirring to obtain a mixed solution C;
and S4, adding the residual amount of citric acid into the mixed solution C, mixing and stirring to obtain the bacteriostatic itching-relieving agent.
Firstly, 45 percent of dandelion extract and 65 percent of turpentine extract are mixed with the extraction mixture, as turpentine has stronger antifungal effect and also has anti-inflammatory effect, but turpentine has strong smell, as the turpentine is of an aromatic substance structure, if the dandelion extract, the turpentine extract and the extraction mixture are simultaneously mixed at one time, the functions of essential oil are easily offset, the compatibility between the essential oil is different, the incompatibility also easily occurs, and the particularity of aloe liquid increases the intermiscibility difficulty between the essential oil, therefore, the essential oil needs to be added separately, part of the dandelion extract and the turpentine extract are added into the extraction mixture firstly and stirred, add a small amount of citric acid again, utilize the characteristic of citric acid, when adjusting pH value neutral, when letting each essential oil and aloe dissolve mutually, can also guarantee the stability of structure between each substance, can not appear offsetting each other between the function, and the long-time exposure of turpentine in the air, the stink can strengthen gradually, the colour can turn yellow gradually, the longer the time that needs the stirring, the time of turpentine and air contact just longer, cause the stink grow easily, the condition that the colour deepens, the dandelion contains peculiar taraxasterol, unique structural feature such as taraxasterol, can guarantee in the stirring, thereby reduce the oxidation of turpentine and reduce the condition that causes the stink grow the colour deepening.
Preferably, the preparation method of the eucalyptus citriodora leaf extract comprises: cleaning and drying a proper amount of lemon eucalyptus leaves, placing the dried lemon eucalyptus leaves into a beaker filled with ethanol solution for mashing, filtering residues after mashing to obtain an organic mixture, concentrating the organic mixture by a rotary evaporator, filtering after concentration, and performing reflux purification extraction to obtain the lemon eucalyptus leaf extract.
Preferably, the preparation method of the aloe extract comprises: cleaning appropriate amount of aloe, drying, peeling dried aloe, collecting aloe liquid, grinding the collected aloe liquid into juice, placing into a beaker, adding complex enzyme for enzymolysis, filtering by an oscillator after enzymolysis, performing reflux purification extraction after filtering, sterilizing at high temperature after qualified extraction to obtain extract, wherein the enzymolysis temperature is 39-45 ℃, the enzymolysis pH value is 4.1-5.0, and the enzymolysis time is 1.5-2.5h; the adding weight of the compound enzyme agent is 0.15-0.25% of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 3-5 parts of cellulase, 3-4 parts of carboxylase, 2-4 parts of glycosidase and 1.5-2.5 parts of pectinase.
The characteristic of aloe can cause extraction difficulty or easily reduce the activity of aloe, and the aloe can be extracted by using the processes of enzymolysis and the like under the condition of not reducing the activity.
Preferably, the preparation method of the aloe extract comprises: cleaning appropriate amount of aloe, drying, peeling dried aloe, collecting aloe liquid, grinding the collected aloe liquid into juice, placing into a beaker, adding complex enzyme for enzymolysis, filtering by an oscillator after enzymolysis, performing reflux purification extraction after filtering, performing high-temperature sterilization after qualified extraction to obtain an extract, wherein the enzymolysis temperature is 40-42 ℃, the enzymolysis pH value is 4.5-5.0, and the enzymolysis time is 1.8-2.3h; the adding weight of the compound enzyme agent is 0.15-0.25% of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 4 parts of cellulase, 3 parts of carboxylase, 3 parts of glycosidase and 2.5 parts of pectinase.
Preferably, the aloe extract is prepared by a method comprising the steps of:
sterilizing at 65-72 deg.C for 8-10s at 135 deg.C, and cooling to room temperature.
Compared with the prior art, the invention has the following effects: 1. the compound essential oil has a synergistic effect, can increase mosquito repelling and bacteriostatic effects and relieve itching, and is used together to play a role.
2. The chemical compositions are basically consistent, and the drug effects are consistent or improved. The method saves cost, saves time and is easy to operate.
Detailed Description
The present invention will be described in detail with reference to examples.
Example 1
An antibacterial antipruritic comprises 45-55 parts of Eucalyptus citriodora leaf extract, 15-20 parts of aloe extract, 10-15 parts of turpentine oil extract, 7-12 parts of sulfur, 10-15 parts of dandelion extract and 10-15 parts of citric acid.
Example 2
An antibacterial antipruritic comprises 51 parts of Eucalyptus citriodora leaf extract, 17 parts of Aloe extract, 11 parts of turpentine oil extract, 10 parts of sulfur, 13 parts of herba Taraxaci extract and 13 parts of citric acid.
Example 3
An antibacterial antipruritic comprises 45-55 parts of Eucalyptus citriodora leaf extract, 15-20 parts of aloe extract, 10-15 parts of turpentine oil extract, 7-12 parts of sulfur, 10-15 parts of dandelion extract and 10-15 parts of citric acid.
Comparative example 1
In comparison with example 1, comparative example 1 did not contain sulfur and dandelion extract, and the rest was the same as example 1.
Comparative example 2
In comparison with example 2, comparative example 2 has no citric acid added, and the remainder is identical to the example.
The examples 1 to 3 and the comparative examples 1 to 2 were subjected to a cooling and soothing experiment, a bacteriostatic experiment and an antipruritic experiment, and the experimental data of the antibacterial effect are shown in table 1;
1. bacteriostatic test
The test method comprises the following steps: 40 volunteers (age 5-15 years) are immediately divided into 8 groups according to the parallel comparison principle, each group comprises 5 volunteers, wherein 1 group of volunteers uses the existing antibacterial antipruritic lotion on the market, the rest 7 groups of volunteers respectively use the antibacterial antipruritic lotion of the embodiment 1-3, and the experimental volunteers apply the antibacterial antipruritic lotion on the affected part for one week.
After one week of use: the skin of the affected part of the test volunteer using the bacteriostatic and antipruritic agent of the embodiment 2-3 is improved, the skin does not have a feeling of itching, and the red swelling is gradually relieved; the affected skin of the test volunteers using the bacteriostatic antipruritic agent of example 1 was significantly improved without the feeling of strangeness, and the red swelling was rapidly relieved.
Preparing the bacteriostatic tablet:
taking a sterile and dried filter paper sheet, respectively dripping 1~3 in the embodiment and about 5 mu L of the bacteriostatic lotion in the comparative example 1-2 into each filter paper sheet, then horizontally placing the filter paper sheet in a clean sterile plate, uncovering the plate, placing the plate in a constant-temperature incubator (37 ℃) to bake, or naturally drying the plate at room temperature for later use.
Sticking bacteriostatic agent sample pieces: each test is stuck with 1 infectious bacterium plate, and each plate is stuck with 4 test sample plates and 1 negative control sample plate, and the number of the negative control sample plates is 5. A sample piece was attached to the surface of the plate using sterile forceps. The distance between the centers of the various pieces is more than 25mm, and the distance between the centers of the various pieces and the periphery of the flat plate is more than 15 mm. After the sample is placed, the sample is lightly pressed by using sterile tweezers to be tightly attached to the surface of the flat plate. And (4) covering the plate, placing the plate in a constant-temperature incubator at 37 ℃, and culturing for 16 to 18h for observation results. The diameter of the zone (including the patch) was measured with a vernier caliper and recorded. The test was repeated 3 times, and the average was recorded and calculated.
The evaluation rules are: if the diameter of the bacteriostatic ring is larger than 7mm, the bacteriostatic ring is judged to have bacteriostatic action; if the diameter of the antibacterial ring is less than or equal to 7mm, the product is judged to have no antibacterial effect. And 3 times of repeated tests (total 12 samples) all achieve the result of bacteriostasis, and the sample is judged to be qualified.
TABLE 1
As can be seen from Table 1, the bacteriostatic effects of examples 1-3 were all greater than those of comparative examples 1-2, and examples 1-3 contained sulfur and dandelion extracts, which effectively enhanced the bacteriostatic effect.
Example 4
The preparation method of the bacteriostatic antipruritic is characterized by comprising the following steps of:
s1, adding a eucalyptus citriodora leaf extract and an aloe extract into a reactor at normal temperature and normal pressure, stirring under the condition of an ultrasonic frequency of 35kHz, and stirring and mixing to obtain an extraction mixture;
s2, slowly dripping 45% of dandelion extract and 65% of turpentine extract into the extraction mixture, slowly stirring to obtain a mixed solution A, slowly dripping citric acid into the mixed solution A, adjusting the pH value to 7, and stopping adding the citric acid to obtain a mixed solution B;
s3, adding sulfur into the mixed solution B, stirring for 32min, adding the rest dandelion extract and the rest turpentine oil extract, and slowly stirring to obtain a mixed solution C;
and S4, adding the residual citric acid into the mixed solution C, mixing and stirring to obtain the bacteriostatic antipruritic agent.
In this embodiment, the preparation method of the eucalyptus citriodora leaf extract includes: cleaning and drying a proper amount of lemon eucalyptus leaves, placing the dried lemon eucalyptus leaves into a beaker filled with ethanol solution for mashing, filtering residues after mashing to obtain an organic mixture, concentrating the organic mixture by a rotary evaporator, filtering after concentration, and performing reflux purification extraction to obtain the lemon eucalyptus leaf extract.
In this embodiment, the preparation method of the aloe extract includes: cleaning and drying a proper amount of aloe, cutting the dried aloe into skin, collecting aloe liquid, grinding the collected aloe liquid into juice, putting the juice into a beaker, adding a complex enzyme for enzymolysis, filtering the juice by an oscillator after the enzymolysis, performing reflux purification extraction after the filtration, sterilizing the juice at 70 ℃ after the extraction is qualified, wherein the enzymolysis temperature is 40 ℃, the enzymolysis pH value is 4.7, and the enzymolysis time is 2 hours; the adding weight of the compound enzyme agent is 0.19 percent of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 4 parts of cellulase, 3 parts of carboxylase, 3 parts of glycosidase and 2.5 parts of pectinase.
Example 5
The preparation method of the bacteriostatic antipruritic is characterized by comprising the following steps of:
s1, adding a eucalyptus citriodora leaf extract and an aloe extract into a reactor at normal temperature and normal pressure, stirring under the condition of ultrasonic frequency of 30kHz, and stirring and mixing to obtain an extraction mixture;
s2, slowly dripping 45% of dandelion extract and 65% of turpentine extract into the extraction mixture, slowly stirring to obtain a mixed solution A, slowly dripping citric acid into the mixed solution A, adjusting the pH value to 7, and stopping adding the citric acid to obtain a mixed solution B;
s3, adding sulfur into the mixed solution B, stirring for 30-35min, then adding the rest dandelion extract and the rest turpentine oil extract, and slowly stirring to obtain mixed solution C;
and S4, adding the residual amount of citric acid into the mixed solution C, mixing and stirring to obtain the bacteriostatic itching-relieving agent.
In this embodiment, the preparation method of the eucalyptus citriodora leaf extract includes: cleaning and drying a proper amount of lemon eucalyptus leaves, placing the dried lemon eucalyptus leaves into a beaker filled with ethanol solution for mashing, filtering residues after mashing to obtain an organic mixture, concentrating the organic mixture by a rotary evaporator, filtering after concentration, and performing reflux purification extraction to obtain the lemon eucalyptus leaf extract.
In this embodiment, the preparation method of the aloe extract includes: cleaning and drying a proper amount of aloe, cutting the dried aloe into skin, collecting aloe liquid, grinding the collected aloe liquid into juice, putting the juice into a beaker, adding a complex enzyme for enzymolysis, filtering the juice by an oscillator after the enzymolysis, performing reflux purification extraction after the filtration, sterilizing the juice at 65 ℃ after the extraction is qualified, wherein the sterilization temperature is 135 ℃ and the sterilization time is 8s, cooling the juice to the normal temperature after the sterilization is finished to obtain an extract, wherein the enzymolysis temperature is 39 ℃, the enzymolysis pH value is 4.1, and the enzymolysis time is 1.5h; the adding weight of the compound enzyme agent is 0.15 percent of the total weight of the aloe juice, and the compound enzyme agent comprises the following enzymes in parts by weight: 3 parts of cellulase, 3 parts of carboxylase, 2 parts of glycosidase and 1.5 parts of pectinase.
Example 6
The preparation method of the bacteriostatic antipruritic is characterized by comprising the following steps of:
s1, adding a eucalyptus citriodora leaf extract and an aloe extract into a reactor at normal temperature and normal pressure, stirring under the condition of ultrasonic frequency of 40kHz, and stirring and mixing to obtain an extraction mixture;
s2, slowly dripping 45% of dandelion extract and 65% of turpentine extract into the extraction mixture, slowly stirring to obtain a mixed solution A, slowly dripping citric acid into the mixed solution A, adjusting the pH value to 7, and stopping adding the citric acid to obtain a mixed solution B;
s3, adding sulfur into the mixed solution B, stirring for 35min, adding the rest dandelion extract and the rest turpentine oil extract, and slowly stirring to obtain a mixed solution C;
and S4, adding the residual citric acid into the mixed solution C, mixing and stirring to obtain the bacteriostatic antipruritic agent.
In this embodiment, the preparation method of the eucalyptus citriodora leaf extract includes: cleaning and drying a proper amount of lemon eucalyptus leaves, placing the dried lemon eucalyptus leaves into a beaker filled with ethanol solution for mashing, filtering residues after mashing to obtain an organic mixture, concentrating the organic mixture by a rotary evaporator, filtering after concentration, and performing reflux purification extraction to obtain the lemon eucalyptus leaf extract.
In this embodiment, the preparation method of the aloe extract includes: cleaning and drying a proper amount of aloe, cutting the dried aloe into skin, collecting aloe liquid, grinding the collected aloe liquid into juice, putting the juice into a beaker, adding a complex enzyme for enzymolysis, filtering the juice by an oscillator after the enzymolysis, performing reflux purification extraction after the filtration, sterilizing the juice at 72 ℃ after the extraction is qualified, wherein the sterilization temperature is 135 ℃ and the sterilization time is 10s, cooling the juice to normal temperature after the sterilization is finished to obtain an extract, wherein the enzymolysis temperature is 45 ℃, the enzymolysis pH value is 5.0, and the enzymolysis time is 2.5 hours; the adding weight of the compound enzyme agent is 0.25 percent of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 5 parts of cellulase, 4 parts of carboxylase, 4 parts of glycosidase and 2.5 parts of pectinase.
Comparative example 3
In contrast to example 4, in comparative example 3, the dandelion extract and the turpentine extract were not added in portions but directly added together in the S2 step, and the rest was identical to example 4.
Comparative example 4
In contrast to example 4, comparative example 4 did not adjust the pH first, but the total amount of citric acid was added directly after obtaining mixture C, and the rest was the same as example 4.
Comparative example 5
In contrast to example 4, comparative example 5 did not employ enzymatic hydrolysis during the aloe extract preparation process, and the remainder was identical to example 4.
Comparative example 6
In contrast to example 4, comparative example 6 does not use the method of preparing the eucalyptus citriodora leaf extract, in which the eucalyptus citriodora leaves are mashed in an ethanol solution and then extracted by refluxing, as in example 5.
Bacteriostatic experiments are carried out on examples 4-6 and comparative examples 3-6, and the experimental data of the antibacterial effect are shown in Table 2;
1. bacteriostatic test
The test method comprises that 40 volunteers (aged 5-15 years) are divided into 8 groups according to the parallel comparison principle, each group comprises 5 volunteers, wherein 1 group of volunteers uses the existing antibacterial antipruritic lotion on the market, the rest 7 groups of volunteers respectively use the antibacterial antipruritic lotions of the embodiments 1-3, and the experimental volunteers apply the antibacterial antipruritic lotion on the affected part for one week.
After one week of use: the skin of the affected part of the test volunteer using the antibacterial antipruritic lotion in the embodiments 2-3 is improved, no itching feeling exists, and the red and swelling gradually subsides; the affected skin of the test volunteer using the bacteriostatic antipruritic lotion in example 1 was significantly improved without itching and the red swelling was rapidly relieved.
Preparing the bacteriostatic tablet:
taking a sterile and dried filter paper sheet, respectively dripping about 5 mu L of the bacteriostatic lotion of the embodiment 4-6 and the control example 3-6 into each filter paper sheet, then flatly placing the filter paper sheet in a clean sterile plate, uncovering the plate, placing the plate in a constant temperature incubator (37 ℃) for baking, or placing the plate at room temperature for natural drying for later use.
Sticking bacteriostatic agent sample pieces: each test is stuck with 1 infectious bacterium plate, and each plate is stuck with 4 test sample plates and 1 negative control sample plate, and the number of the negative control sample plates is 5. A sample piece was attached to the surface of the plate using sterile forceps. The distance between the centers of the various pieces is more than 25mm, and the distance between the centers of the various pieces and the periphery of the flat plate is more than 15 mm. After the sample is placed, the sample is lightly pressed by using sterile tweezers to be tightly attached to the surface of the flat plate. And covering the plate, placing the plate in a constant-temperature incubator at 37 ℃, and culturing for 16 to 18h for observation. The diameter of the antibacterial ring (including the patch) was measured with a vernier caliper and recorded. The test was repeated 3 times, and the average was recorded and calculated.
The evaluation rules are: if the diameter of the bacteriostatic ring is larger than 7mm, the bacteriostatic ring is judged to have bacteriostatic action; if the diameter of the antibacterial ring is less than or equal to 7mm, the product is judged to have no antibacterial effect. And 3 times of repeated tests (total 12 samples) all achieve the result of bacteriostasis, and the sample is judged to be qualified.
TABLE 2
As can be seen from Table 2, the bacteriostatic effects of examples 1-3 were all greater than those of comparative examples 3-6, effectively enhancing the bacteriostatic effect.
Comparative example 3 the dandelion extract and the turpentine extract were not added in portions but directly added together, so the bacteriostatic effect was also the worst;
in comparative example 4, the PH was not adjusted first, but the total amount of citric acid was added directly after the mixed solution C was obtained, and the bacteriostatic effect was not as good as in examples 4 to 6;
comparative example 5 does not use an enzymatic hydrolysis method during the preparation of aloe extract, so the activity of aloe is poor and the effect is not as good as in examples 4-6;
comparative example 6 the effect of the method of preparing the extract of eucalyptus citriodora was not as good as in examples 4-6, because the leaves of eucalyptus citriodora were crushed in an ethanol solution and then extracted by refluxing.
The above examples only show some embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit of the invention, and these changes and modifications are all within the scope of the invention. Therefore, the patent and protection scope of the present invention should be subject to the appended claims.
Claims (7)
1. An antibacterial antipruritic agent is characterized in that the raw materials comprise 45-55 parts of eucalyptus citriodora leaf extract, 15-20 parts of aloe extract, 10-15 parts of turpentine oil extract, 7-12 parts of sulfur, 10-15 parts of dandelion extract and 10-15 parts of citric acid.
2. A bacteriostatic antipruritic as claimed in claim 1, wherein the raw materials comprise 51 parts of eucalyptus citriodora leaf extract, 17 parts of aloe extract, 11 parts of turpentine oil extract, 10 parts of sulfur, 13 parts of dandelion extract and 13 parts of citric acid.
3. A method for preparing a bacteriostatic antipruritic according to claim 2, which comprises the following steps:
s1, adding a eucalyptus citriodora leaf extract and an aloe extract into a reactor at normal temperature and normal pressure, stirring under the condition of ultrasonic frequency of 30-40 kHz, and stirring and mixing to obtain an extraction mixture;
s2, slowly dripping 45% of dandelion extract and 65% of turpentine extract into the extraction mixture, slowly stirring to obtain a mixed solution A, slowly dripping citric acid into the mixed solution A, adjusting the pH value to 7, and stopping adding the citric acid to obtain a mixed solution B;
s3, adding sulfur into the mixed solution B, stirring for 30-35min, then adding the rest dandelion extract and the rest turpentine oil extract, and slowly stirring to obtain a mixed solution C;
and S4, adding the residual citric acid into the mixed solution C, mixing and stirring to obtain the bacteriostatic antipruritic agent.
4. A method for preparing bacteriostatic and antipruritic agent according to claim 3, wherein the method for preparing the eucalyptus citriodora leaf extract comprises: cleaning and drying a proper amount of lemon eucalyptus leaves, placing the dried lemon eucalyptus leaves into a beaker filled with ethanol solution for mashing, filtering residues after mashing to obtain an organic mixture, concentrating the organic mixture by a rotary evaporator, filtering after concentration, and performing reflux purification extraction to obtain the lemon eucalyptus leaf extract.
5. A method of preparing a bacteriostatic antipruritic according to claim 3, wherein the aloe extract is prepared by a method comprising: cleaning appropriate amount of aloe, drying, cutting skin of dried aloe, collecting aloe liquid, grinding the collected aloe liquid into juice, placing into a beaker, adding complex enzyme for enzymolysis, filtering by an oscillator after enzymolysis, performing reflux purification extraction after filtering, sterilizing at high temperature after qualified extraction to obtain an extract, wherein the enzymolysis temperature is 39-45 ℃, the enzymolysis pH value is 4.1-5.0, and the enzymolysis time is 1.5-2.5h; the adding weight of the compound enzyme agent is 0.15-0.25% of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 3-5 parts of cellulase, 3-4 parts of carboxylase, 2-4 parts of glycosidase and 1.5-2.5 parts of pectinase.
6. A method of preparing a bacteriostatic antipruritic according to claim 3, wherein the aloe extract is prepared by a method comprising: cleaning appropriate amount of aloe, drying, peeling dried aloe, collecting aloe liquid, grinding the collected aloe liquid into juice, placing into a beaker, adding complex enzyme for enzymolysis, filtering by an oscillator after enzymolysis, performing reflux purification extraction after filtering, performing high-temperature sterilization after qualified extraction to obtain an extract, wherein the enzymolysis temperature is 40-42 ℃, the enzymolysis pH value is 4.5-5.0, and the enzymolysis time is 1.8-2.3h; the adding weight of the compound enzyme agent is 0.15-0.25% of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 4 parts of cellulase, 3 parts of carboxylase, 3 parts of glycosidase and 2.5 parts of pectinase.
7. A method for preparing an antibacterial antipruritic according to claim 5, wherein the aloe vera extract is prepared by the method comprising the steps of:
sterilizing at 65-72 deg.C for 8-10s at 135 deg.C, and cooling to room temperature.
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| CN106309165A (en) * | 2016-08-27 | 2017-01-11 | 广东罗浮山国药股份有限公司 | Plant essential oil skin cream and preparation method thereof |
| CN110179693A (en) * | 2019-06-14 | 2019-08-30 | 江西中医药大学 | Mosquito-expelling and antipruritic compound essential oil and preparation method thereof, application and mosquito-expelling and antipruritic articles |
| CN111135209A (en) * | 2020-01-15 | 2020-05-12 | 新余昊洪医用科技有限公司 | Artemisia apiacea spray with effects of preventing malaria, repelling mosquitoes, relieving itching and repairing and preparation method thereof |
| CN111388384A (en) * | 2020-03-25 | 2020-07-10 | 广州瑶芳皮肤健康管理有限公司 | Acne-removing essence containing Chinese herbal medicine composition and preparation method thereof |
| CN111773140A (en) * | 2020-07-21 | 2020-10-16 | 广州润峰婴儿用品有限公司 | Plant essential oil composition and application thereof |
| CN113876680A (en) * | 2021-11-08 | 2022-01-04 | 云南滇凯术源生物科技有限公司 | Plant wet tissue and preparation process thereof |
| CN114158575A (en) * | 2021-12-13 | 2022-03-11 | 江苏时代铭阳生物新技术研究院有限公司 | Preparation method and application of antioxidant and bacteriostatic plant extract |
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