CN109602868A - Plant essence liquid and preparation method thereof and sanitary napkin application - Google Patents

Plant essence liquid and preparation method thereof and sanitary napkin application Download PDF

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Publication number
CN109602868A
CN109602868A CN201910104220.1A CN201910104220A CN109602868A CN 109602868 A CN109602868 A CN 109602868A CN 201910104220 A CN201910104220 A CN 201910104220A CN 109602868 A CN109602868 A CN 109602868A
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China
Prior art keywords
parts
oil
extract
plant essence
essence liquid
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CN201910104220.1A
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Inventor
滕晖
林涛
孟君
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Zhuzhou Qianjin Pharmaceutical Co Ltd
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Zhuzhou Qianjin Pharmaceutical Co Ltd
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Priority to CN201910104220.1A priority Critical patent/CN109602868A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

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Abstract

The invention discloses a kind of plant essence liquid and preparation method thereof and sanitary napkin application.The plant essence liquid is grouped as by each group of following parts by weight: 10 ~ 50 parts of natural flower aroma essential oil, 10 ~ 30 parts of shikonin extract, 20 ~ 50 parts of menthol, 1 ~ 4 part of borneol, 0.03 ~ 0.08 part of phellodendron extract, 100 ~ 300 parts of Tween-80.The present invention in a creative way merges complicated medical fluid active constituent with natural plant essential oils, while so that it is had bacteriostasis efficacy, also has and alleviates the multi-efficiencies such as dysmenorrhea, promoting blood circulation and removing obstruction in channels, relieving mood, balance reproductive system.

Description

Plant essence liquid and preparation method thereof and sanitary napkin application
Technical field
The present invention relates to nursing materials technical fields, more particularly, to a kind of suitable for plant that is antibacterial, alleviating dysmenorrhea Essence and preparation method thereof and sanitary napkin application.
Background technique
Sanitary napkin is female menstrual period using product, is a kind of high water absorbency polymer (SAPS).Menses leak in order to prevent, mesh There is preceding major part sanitary napkin for women its outside to be coated with the sealing structure of plastics, and microorganism is caused extremely to be easy breeding.And And menstrual woman causes vagina pH value unbalance because of the effect of menses, the function reduction of self-cleaning self-cleaning.The survey found that Intermenstrual period, bacterium is reversible to be advanced into vagina, does not pay attention to menstrual hygiene, abuses unclean toilet paper, causes vulva by unclean health Paper and catamenial tampon pollution, germ seize the opportunity growth and intrude into.Many puzzlements of the women by gynecological disease.Use underproof health Towel has 38% people to suffer from serious gynecological disease, and 73% women can feel local skin itch in menstrual period, burn, cusalgia, After 80% or so unclean sanitary napkin for women, the symptoms such as high fever, headache, abdominal pain can also occur in menstrual period.
In order to assign the antibiotic effect of sanitary napkin, the prior art usually increases antibiotic layer in sanitary napkin, however at present Allergy rate is higher, effect material effect is not easy to play, sanitary napkin manufacture technology difficulty rises, high rejection rate, and sanitary napkin Bacteriostasis property, antimicrobial stability are low.And various antibacterial agents in the market, eucaryotic cell structure can be destroyed to a certain extent, damaged Hurt cell, safety is not high, all larger to the stimulation of skin and vagina mucosa.In addition, existing antimicrobial form sanitary napkin often only Focus on restraining and sterilizing bacteria effect, effect is excessively single, and less for the concern of the long-term stability of product, is unable to satisfy modern female Growing a variety of demands.
Summary of the invention
Deficiency existing for technical deficiency especially feminine hygiene articles for nursing materials in the prior art, the present invention mention For a kind of plant essence liquid with antibacterial alleviation dysmenorrhea effect, the plant essence liquid is living by complicated medical fluid in a creative way Property ingredient merged with natural plant essential oils, make its play bacteriostasis efficacy while, also alleviate dysmenorrhea, activating microcirculation and removing stasis medicinal, relax Slow unhealthy emotion, balance reproductive system etc. play a significant role.
Another technical problem to be solved by the present invention is that providing the preparation method of the plant essence liquid.
The invention solves an also technical problem be to provide the application of the plant essence liquid.
The purpose of the present invention is achieved through the following technical solutions:
A kind of plant essence liquid with antibacterial alleviation dysmenorrhea effect is provided, is grouped as by each group of following parts by weight: day Right 10~50 parts of Rose Absolute, 10~30 parts of shikonin extract, 20~50 parts of menthol, 1~4 part of borneol, phellodendron extract 0.03~0.08 part, 100~300 parts of Tween-80；The natural flower aroma essential oil by Geranium Essential, citronella oil, neroli oil and Rose oil composition.
Preferably, described to be grouped as with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect by each group of following parts by weight: 20~40 parts of natural flower aroma essential oil, 15~25 parts of shikonin extract, 30~50 parts of menthol, 1~3 part of borneol, phellodendron extract 0.04~0.06 part, 200~280 parts of Tween-80.
Most preferably, the plant essence liquid is grouped as by each group of following parts by weight: 40 parts of natural flower aroma essential oil, Asian puccoon 20 parts of extracting solution, 45 parts of menthol, 2 parts of borneol, 0.06 part of phellodendron extract, 250 parts of Tween-80.
Containing the alkaloids such as a large amount of Berberine hydrochlorides, jateorrhizine, phellodendrine in Cortex Phellodendri, have heat-clearing and damp-drying drug, detoxification sore treatment, Phellodendron extract is used in feminine hygiene articles by antibacterial and other effects, enhancing antibacterial, antiallergy, anti-inflammatory and other effects；Asian puccoon is to gold Staphylococcus aureus, Escherichia coli, influenza virus, shigella dysenteriae, dermatophyte have inhibiting effect.The present invention is through too long Phase test, mutually arranges in pairs or groups phellodendron extract with shikonin extract according to reasonable dosage, then be equipped with it is antibacterial, antipruritic, except different The peppermint of taste, analgesia, salubrious and other effects, borneol, obtain and are suitable for antibacterial, analgesic plant essence liquid, by the plant essence Liquid is applied in care product, especially in women especially maiden's sanitary towels, is not only able to effectively prevent menstrual period bacterium It breeds, moreover it is possible to which the effect for playing certain alleviation dysmenorrhea brings salubrious comfort to menstruating women.
Shikonin extract in the present invention can be made by conventional method in that art, and the present invention provides a kind of preferred method It is made: after Asian puccoon and solvent are mixed, being extracted by conventional method in that art.The solvent can mention for this field is conventional Take solvent, preferably one of water, ethyl alcohol and 1,3-BDO or a variety of.The method of the extraction can be infusion process, diacolation Method, decocting method, reflux extraction or ultrasonic extraction etc..Preferably, the shikonin extract is by the purple Jing Guo quality testing Grass crushed 30 meshes, with concentration be 85~95% alcohol dipping, after diacolation 36~60 hours, recycle ethyl alcohol to get.
Phellodendron extract in the present invention can be made by conventional method in that art, and the present invention provides a kind of preferred method It is made: after Cortex Phellodendri medicinal material and solvent are mixed, being extracted by conventional method in that art.The solvent can be conventional for this field Extraction solvent, preferably one of water, ethyl alcohol and 1,3-BDO or a variety of.The method of the extraction can for infusion process, Percolation, decocting method, reflux extraction or ultrasonic extraction etc..Preferably, the phellodendron extract is to take Cortex Phellodendri medicinal material, with 70 ~80% alcohol reflux extracts 2~5 times, extracts 1~3h every time, and combined extract is condensed into medicinal extract and obtains.
The present invention carries out preferably, the concentration of principle active component not only can be improved by the extracting method to each extract To improving therapeutic effect, while be fully extracted the other ingredients for having auxiliary effect in medicinal material, in other medicinal materials at Divide and play synergistic effect together, makes products obtained therefrom that there is good antibacterial, analgesia regulating menoxenia.
To assign plant essence liquid multi-efficiency, the plant essence liquid also includes natural flower aroma essential oil.Preferably, described Natural flower aroma essential oil is grouped as by each group of following parts by weight: 4~8 parts of Geranium Essential, 4~10 parts of citronella oil, neroli oil 1~ 6 parts, 1~6 part of rose oil.
It is further preferred that the natural flower aroma essential oil is grouped as by each group of following parts by weight: Geranium Essential 4~6 Part, 5~8 parts of citronella oil, 2~4 parts of neroli oil, 1~3 part of rose oil.
Further to play the bacteriostasis of collaboration, and assigns plant essence liquid and alleviate dysmenorrhea, relieving mood, nourish son The multi-efficiencies such as palace, the present invention naturally plant Geranium Essential, citronella oil, neroli oil and rose oil etc. according to reasonable dosage Object essential oil compatibility, and above-mentioned medical fluid active constituent coordinated, obtain can bacteriostasis antibiosis and menstruation regulating of easing pain, activating microcirculation and removing stasis medicinal, The plant essence conditioning liquid for balancing reproductive system, solves the problems, such as that existing female sanitary towel has a single function.
In natural flower aroma essential oil of the invention, the most important effect of rose oil is activating microcirculation and removing stasis medicinal, clearing and activating the channels and collaterals, alleviates Dysmenorrhea strengthens utero ovarian function, smooths the dejected mood of anxiety, and Geranium Essential is extraordinary balance essential oil, possesses Good adjusting estrogen secreting function, and neroli oil has calming nerves effect, natural flower aroma essential oil of the present invention In, Geranium Essential and neroli oil coordinated are the good partners for balancing female reproductive system, improving female menstrual period；Above-mentioned Fusion has the citronella oil of antibacterial and bacteriostasis in three kinds of essential oils, and the present invention is found surprisingly that above-mentioned mixed essential oil not only without broken The speciality of bad every kind of essential oil, makes mixed essential oil with better function instead.
Present invention simultaneously provides the preferred preparation methods of the plant essence liquid, comprising the following steps:
S1. natural flower aroma essential oil is dissolved in 85~95% ethyl alcohol, is sufficiently dissolved, it is spare；
S2. it is put into the natural flower aroma essential oil alcoholic solution of step S1 after mixing menthol, borneol, Cortex Phellodendri is then added and mentions Object and shikonin extract are taken, after mixing evenly, 85~95% ethyl alcohol is added to 150~300 parts, then carry out ultrasonic wave dissolution, Obtain concentrate；
S3. Tween-80 is added in the concentrate obtained to step S2, then dilutes 25~50 times with 45~55% ethyl alcohol, To obtain the final product.
Preferably, in step S1, the mass ratio of the natural flower aroma essential oil and ethyl alcohol is 1~1.5:2.
Present invention simultaneously provides described with application of the plant essence liquid in sanitary napkin that be antibacterial, alleviating dysmenorrhea effect, Application especially in maiden's sanitary napkin.
Compared with prior art, the beneficial effects of the present invention are:
Plant essence liquid of the invention is by shikonin extract, phellodendron extract, peppermint, borneol and natural flower aroma essential oil with suitable When ratio compatibility, have alleviate dysmenorrhea, prevent menstrual period microorganism infection, effectively avoid menstrual disease occur and other effects, especially It is the especially maiden with preferred ratio combined application in female sanitary towel product by above-mentioned composition and natural flower aroma essential oil In sanitary towels, be not only able to effectively inhibit menstrual period bacteria breed, moreover it is possible to play it is promoting blood circulation and removing obstruction in channels, nourish uterus, releive it is bad The effect of mood, shelf life effectively extend.
The present invention is according to scientific compatibility by natural plant essential oils such as Geranium Essential, citronella oil, neroli oil and rose oils With medical fluid active constituent coordinated, obtained plant essence liquid plays bacteriostasis antibiosis, alleviates dysmenorrhea, relieving mood, promoting blood circulationization The coordinative role of the stasis of blood solves the problems, such as that existing female sanitary towel has a single function.
The preparation method simple process of plant essence liquid provided by the invention, it is easy to operate, it is big industrialization can be suitable for Production improves production efficiency.
Specific embodiment
To facilitate the understanding of the present invention, present invention work more comprehensively, is meticulously described below in conjunction with embodiment, but this hair Bright protection scope is not limited to embodiment in detail below.
Unless otherwise defined, all technical terms used hereinafter and the normally understood meaning of those skilled in the art It is identical.Technical term used herein is intended merely to the purpose of description specific embodiment, it is no intended to limit of the invention Protection scope.
Geranium Essential, citronella oil, neroli oil, rose oil in following embodiment extract by the following method.
Geranium Essential: being handled using flower, blade and stem of the steam distillation to fish pelargonium, from seeing One drop condensing droplet occurs starting timing, after 4h, terminates distillation, distillation speed 90mL/h oozes condensate liquid weight with above-mentioned 0.6 times of anhydrous sodium sulfate is dried, obtain with like rose, spearmint taste light olive-green liquid to get.
Citronella oil: lemon-grass is crushed, and is crossed 30 meshes and is placed in extraction kettle, the soybean oil of 5 times of weight is added, using Asia Critical butane is extracted, and extract liquor is obtained, wherein and extraction temperature is 60 DEG C, extracting pressure 1MPa, extraction time 6h, Then by extract liquor separate to get.
Neroli oil: being handled flores aurantii using steam distillation, is counted since seeing that the first drop condensing droplet occurs When, after 6h, terminate distillation, distillation speed 80mL/h, to above-mentioned condensate liquid purify 4 times to get.
Rose oil: fresh rose is crushed, and is crossed 40 meshes, is then obtained using supercritical carbon dioxide extraction It arrives；The pressure of supercritical carbon dioxide extraction be 20MPa, temperature be 40 DEG C, extraction time be 3 hours to get.
Phellodendron extract, shikonin extract in following embodiment extract by the following method.
Phellodendron extract: taking Cortex Phellodendri medicinal material, is extracted 3 times with 75% alcohol reflux, extracts 2h every time, combined extract, Be condensed into relative density be 1.1~1.3 medicinal extract to get.
Shikonin extract: crushed 30 meshes for the Asian puccoon after quality testing, the alcohol at normal temperature for being 95% with concentration Diacolation 48 hours, with the speed of 60ml per minute slowly diacolation, add 95% ethyl alcohol at any time to keep liquid level not less than medicinal material table Percolate is collected in face, and percolate is added in ethanol recovery device and recycles ethyl alcohol, recovered liquid is filtered, and removes the impurity in liquid, To obtain the final product.
Embodiment 1
The present embodiment provides a kind of with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect, by each group of following parts by weight Be grouped as: 10 parts of natural flower aroma essential oil, 50 parts of menthol, 4 parts of borneol, 0.08 part of phellodendron extract, is spat 30 parts of shikonin extract - 80 100 parts of temperature.
Above-mentioned natural flower aroma essential oil is grouped as by each group of following parts by weight: 8 parts of Geranium Essential, 4 parts of citronella oil, and flores aurantii 1 part, 6 parts of rose oil of oil.
The above-mentioned preparation method with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect, includes the following steps:
S1. natural flower aroma essential oil is dissolved in 95% ethyl alcohol by above-mentioned parts by weight, the quality of natural flower aroma essential oil and ethyl alcohol It is spare than sufficiently dissolving for 1:2；
S2. it is put into the natural flower aroma essential oil alcoholic solution of step S1 after mixing peppermint, borneol, Cortex Phellodendri is then added and extracts After mixing evenly 95% ethyl alcohol is added to 200 parts, then it is transparent molten to be dissolved to purple for progress ultrasonic wave in object and shikonin extract Liquid is to get concentrate；
S3. Tween-80 is added in the concentrate obtained to step S2, then with 55% ethyl alcohol dilute 50 times to get.
Embodiment 2
The present embodiment provides a kind of with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect, by each group of following parts by weight Be grouped as: 50 parts of natural flower aroma essential oil, 20 parts of menthol, 1 part of borneol, 0.03 part of phellodendron extract, is spat 10 parts of shikonin extract - 80 300 parts of temperature.
Above-mentioned natural flower aroma essential oil is grouped as by each group of following parts by weight: 4 parts of Geranium Essential, 10 parts of citronella oil, and orange 6 parts of caul-fat, 1 part of rose oil.
The above-mentioned preparation method with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect is referring to embodiment 1.
Embodiment 3
The present embodiment provides a kind of with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect, by each group of following parts by weight Be grouped as: 20 parts of natural flower aroma essential oil, 25 parts of shikonin extract, 30 parts of menthol, 3 parts of borneol, 0.04 part of phellodendron extract are spat - 80 200 parts of temperature.
Above-mentioned natural flower aroma essential oil is grouped as by each group of following parts by weight: 6 parts of Geranium Essential, 5 parts of citronella oil, and flores aurantii 2 parts, 2 parts of rose oil of oil.
The above-mentioned preparation method with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect is referring to embodiment 1.
Embodiment 4
The present embodiment provides a kind of with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect, by each group of following parts by weight Be grouped as: 30 parts of natural flower aroma essential oil, 15 parts of shikonin extract, 40 parts of menthol, 2 parts of borneol, 0.05 part of phellodendron extract are spat - 80 280 parts of temperature.
Above-mentioned natural flower aroma essential oil is grouped as by each group of following parts by weight: 4 parts of Geranium Essential, 6 parts of citronella oil, and flores aurantii 3 parts, 5 parts of rose oil of oil.
The above-mentioned preparation method with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect is referring to embodiment 1.
Embodiment 5
The present embodiment provides a kind of with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect, by each group of following parts by weight Be grouped as: 40 parts of natural flower aroma essential oil, 20 parts of shikonin extract, 45 parts of menthol, 2 parts of borneol, 0.06 part of phellodendron extract are spat - 80 250 parts of temperature.
Above-mentioned natural flower aroma essential oil is grouped as by each group of following parts by weight: 5 parts of Geranium Essential, 8 parts of citronella oil, and flores aurantii 4 parts, 3 parts of rose oil of oil.
The above-mentioned preparation method with plant essence liquid that is antibacterial, alleviating dysmenorrhea effect is referring to embodiment 1.
Comparative example 1
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, mentions in the plant essence liquid without Cortex Phellodendri Take object.
Comparative example 2
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, mentions in the plant essence liquid without Asian puccoon Take liquid.
Comparative example 3
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and menthol is free of in the plant essence liquid And borneol.
Comparative example 4
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and natural flowers are free of in the plant essence liquid Essential oil.
Comparative example 5
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and India is free of in the natural flower aroma essential oil Certain herbaceous plants with big flowers essential oil and neroli oil.
Comparative example 6
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and rose is free of in the natural flower aroma essential oil Caul-fat.
Comparative example 7
Referring to the process conditions of embodiment 5, the main distinction is this comparative example, and lemongrass is free of in the natural flower aroma essential oil Oil.
Comparative example 8
The process conditions of this comparative example reference embodiment 5, the main distinction are that the plant essence liquid is by following parts by weight Each group be grouped as: 3 parts of Geranium Essential, 11 parts of citronella oil, 0.5 part of neroli oil, 7 parts of rose oil, 8 parts of shikonin extract, 55 parts of menthol, 0.5 part of borneol, 0.02 part of phellodendron extract, 320 parts of Tween-80.
Comparative example 9
The process conditions of this comparative example reference embodiment 5, the main distinction are that the plant essence liquid is by following parts by weight Each group be grouped as: 9 parts of Geranium Essential, 3 parts of citronella oil, 7 parts of neroli oil, 0.5 part of rose oil, 32 parts of shikonin extract, 18 parts of menthol, 5 parts of borneol, 0.09 part of phellodendron extract, 95 parts of Tween-80.
Physicochemical property detection
Indices inspection is carried out to the plant essence liquid that Examples 1 to 5 is prepared according to standard GB/T 15979-2002 It surveys, testing result is as follows:
(1) organoleptic indicator
Appearance: the uniform liquid of light violet magenta emulsus；
Fragrance: Rose Essentielle meets regulation fragrance.
(2) physical and chemical index
PH value (25 DEG C): 5.5；
Heat-resistant stability: kept at 40 ± 1 DEG C for 24 hours, restore to after room temperature with test before no significant difference；
Cold-resistant stability: keeping for 24 hours at -8 ± 2 DEG C, after restoring to room temperature with test before no significant difference.
(3) microorganism and hygienic chemistry index
By amenities (disinfection grade) the detection micro- life of plant essence liquid of the present invention of gynecologic menstrual in 15979 standard of GB/T Object and hygienic chemistry index, testing result are shown in Table 1.
Table 1
Sanitary index Standard requirements Testing result Single item evaluation
Total number of bacterial colonies, CFU/g ≤20 ≤10 It is qualified
Fungus colony sum, CFU/g It must not detect It is not detected It is qualified
Heat-resisting coliform, g It must not detect It is not detected It is qualified
Staphylococcus aureus, g It must not detect It is not detected It is qualified
Hemolytic streptococcus, g It must not detect It is not detected It is qualified
Pseudomonas aeruginosa, g It must not detect It is not detected It is qualified
Skin irritation test
By taking plant essence liquid prepared by the method for Examples 1 to 5 as an example, observation of plant Essence to the irritation of skin and Allergic reaction provides reference to evaluate its safety.
(1) skin irritation test is carried out using rabbit, divides intact skin group and damage skin group, for 24 hours by rabbit before test Back backbone diamond wool shaves off, and the plant essence liquid prepared respectively with the embodiment of the present invention 1~5 connects with the holding of rabbit skin and mucosa After touching 1d, continuous 7d, whether there is or not the stimulate the reactions such as erythema, oedema for observation skin.
(2) using cavy carry out skin allergy experiment, weekly with the embodiment of the present invention 1~5 prepare plant essence liquid with Guinea pig skin mucous membrane is kept in contact 2 times, contacts 4h or more every time, continuous 3 weeks, whether there is or not the allergy such as erythema, oedema are anti-for observation skin It answers.
Experimental result:
The intact skin and damaged skin of rabbit, remove after being intended for single use or be used for multiple times for 24 hours, respectively at 1,24,48, 72h observation, is showed no erythema and oedema, and stimulate the reaction mean scores are < 0.5, nonirritant.
In guinea pig skin allergic experiment, does not occur the cutaneous anaphylaxises such as the obvious erythema of skin, oedema and other are systemic Allergic reaction.
Therefore, plant essence liquid of the invention will not cause irritative response to rabbit intact skin and damage skin, right Guinea pig skin has good cutaneous safety without allergic reaction.
Biocidal property detection
Biocidal property detection is carried out to the plant essence liquid that the present invention is prepared, predominantly detects plant essence liquid to large intestine bar Bacterium, staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and hemolytic streptococcus bacteriostasis rate, bacteriostasis rate testing result is shown in Table 2.
Table 2
As the result is shown: by the plant essence liquid that is prepared of the present invention rich in a variety of bacteriostatic activities such as Berberine hydrochloride at Point, also there is bacteriostasis antibiosis effect, especially to Escherichia coli, staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and molten Hemorrhagic streptococcic rejection is good.
Detection of Stability
Detection of Stability is carried out to plant essence liquid prepared by the present invention, by taking plant essence liquid prepared by embodiment 3 as an example, Reference standard GB15979-2002, sample are placed in stability test case, keep 37 DEG C of temperature, relative humidity 80% are lower to save 3 Stripping property (anti-) antibacterial product bacteriostasis property test is carried out after a month.Test result is shown in Table 3.
Specific test method are as follows: action time 5 minutes or more big to experimental strain when test temperature is 25 DEG C ± 1 DEG C Enterobacteria, staphylococcus aureus have bacteriostasis, and product is to the bacteriostasis of Escherichia coli, staphylococcus aureus in room temperature Under at least keep 2 years.
Table 3
Note: it is 3.3 × 104 (2.4 × 104~4.4 × 104) cfu/ pieces that S. aureus-positive, which compares bacterium amount, greatly Enterobacteria positive control bacterium amount is 4.1 × 104 (3.4 × 104~4.8 × 104) cfu/ pieces.
Alleviate dysmenorrhea measure of merit
The plant essence liquid that above-described embodiment 1~5 is prepared is applied in maiden's sanitary towels, and collection has dysmenorrhea 360 people of female patient of symptom, the age 13~20 years old, is divided into 6 groups, wherein the 1st~5 is to use the embodiment of the present invention 1~5 Maiden's sanitary napkin made of the plant essence liquid being prepared, the 6th group is control group, using commercially available common maiden's type sanitary napkin, The performance for evaluating plant essence liquid of the present invention is investigated with the experience of 3 menstrual cycles, specific test result is shown in Table 4.
Assessment of performance standard:
It is effective: all to be disappeared using rear feeling of pain symptom, intermenstrual period does not recur without significant discomfort, follow-up half a year；
It is effective: to be obviously improved using rear feeling of pain symptom, occasionally have dysmenorrhea, but relatively slight；
It is invalid: to be not improved using rear feeling of pain symptom.
Table 4
As shown in Table 4, after using 3 menstrual cycles of plant essence liquid prepared by the present invention, obvious effective rate is up to 95%, always has Efficiency is 98.33%, and the information through using the volunteer for loading plant essence liquid maiden's sanitary napkin of the present invention to feed back proves, this hair The plant essence liquid of bright offer can be with the unsmooth caused severe pain of rapid recovery dysmenorrhea and menstruation discharge, and sees through safety It examines, does not find any adverse reaction, it is without side-effects.
Product measure of merit
The plant essence liquid that above-described embodiment 1~5 and comparative example 1~9 are prepared is applied to maiden's sanitary towels In, it then carries out measure of merit, chooses with dysmenorrhea, female patient 140 of menstrual disease, the age 15~21 years old, average mark It is 14 groups, mean value is scored with the experience of 5 menstrual cycles to investigate the performance for evaluating plant essence liquid of the present invention, evaluation mark It is quasi- as shown in table 5.
5 standards of grading of table
Scoring Description
80~100 Effect is obvious
60~80 Effect is general
40~60 There is a degree of improvement
< 40 points No effect
After test carries out 5 menstrual cycles, acquisition experimental result is as shown in table 6:
Table 6
Experimental result is shown: plant essence liquid disclosed by the invention according to reasonable dosage by Geranium Essential, citronella oil, The natural plant essential oils compatibility such as neroli oil and rose oil, with medical fluid active constituent coordinated, obtained plant essence liquid was both Energy bacteriostasis antibiosis, and dysmenorrhea, balance of releiving, promoting blood circulation and removing obstruction in channels, nourishing uterus can be alleviated, solve existing female sanitary towel function list One the problem of.
Obviously, above-described embodiment is only intended to clearly illustrate technical solution of the present invention example, and is not Restriction to embodiments of the present invention.For those of ordinary skill in the art, on the basis of the above description also It can make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all Made any modifications, equivalent replacements, and improvements etc. within the spirit and principles in the present invention should be included in right of the present invention and want Within the protection scope asked.

Claims (10)

1. a kind of plant essence liquid, which is characterized in that be grouped as by each group of following parts by weight: 10 ~ 50 parts of natural flower aroma essential oil, 10 ~ 30 parts of shikonin extract, 20 ~ 50 parts of menthol, 1 ~ 4 part of borneol, 0.03 ~ 0.08 part of phellodendron extract, Tween-80 100 ~ 300 parts；The natural flower aroma essential oil is made of Geranium Essential, citronella oil, neroli oil and rose oil.
2. plant essence liquid according to claim 1, which is characterized in that be grouped as by each group of following parts by weight: natural flowers 20 ~ 40 parts of essential oil, 15 ~ 25 parts of shikonin extract, 30 ~ 50 parts of menthol, 1 ~ 3 part of borneol, phellodendron extract 0.04 ~ 0.06 Part, 200 ~ 280 parts of Tween-80.
3. plant essence liquid according to claim 1 or claim 2, which is characterized in that be grouped as by each group of following parts by weight: natural 40 parts of Rose Absolute, 20 parts of shikonin extract, 45 parts of menthol, 2 parts of borneol, 0.06 part of phellodendron extract, Tween-80 250 Part.
4. any one plant essence liquid according to claim 1 ~ 3, which is characterized in that the natural flower aroma essential oil is by following heavy The each group of amount part is grouped as: 4 ~ 8 parts of Geranium Essential, 4 ~ 10 parts of citronella oil, 1 ~ 6 part of neroli oil, 1 ~ 6 part of rose oil.
5. plant essence liquid according to claim 4, which is characterized in that the natural flower aroma essential oil is by each of following parts by weight Group is grouped as: 4 ~ 6 parts of Geranium Essential, 5 ~ 8 parts of citronella oil, 2 ~ 4 parts of neroli oil, 1 ~ 3 part of rose oil.
6. plant essence liquid according to claim 1, which is characterized in that the shikonin extract the preparation method is as follows: will Asian puccoon after quality testing pulverizes and sieves, and the alcohol dipping for being 85 ~ 95% with concentration after diacolation 36 ~ 60 hours, recycles second Alcohol to get.
7. plant essence liquid according to claim 1, which is characterized in that the phellodendron extract the preparation method is as follows: taking Cortex Phellodendri medicinal material, with 70 ~ 80% alcohol reflux extract 2 ~ 5 times, every time extract 1 ~ 3h, combined extract, be condensed into medicinal extract to get.
8. the preparation method of any one plant essence liquid according to claim 1 ~ 7, which comprises the following steps:
S1. natural flower aroma essential oil is dissolved in 85 ~ 95% ethyl alcohol, is sufficiently dissolved, it is spare；
S2. it is put into the natural flower aroma essential oil alcoholic solution of step S1 after mixing menthol, borneol, phellodendron extract is then added And shikonin extract is added 85 ~ 95% ethyl alcohol to 150 ~ 300 parts, then carries out ultrasonic wave dissolution, be concentrated after mixing evenly Liquid；
S3. Tween-80 is added in the concentrate obtained to step S2, then with 45 ~ 55% ethyl alcohol dilute 25 ~ 50 times to get.
9. the preparation method of plant essence liquid according to claim 8, which is characterized in that in step S1, the natural flower aroma The mass ratio of essential oil and ethyl alcohol is 1 ~ 1.5:2.
10. application of any one of the claim 1 ~ 9 plant essence liquid in sanitary towels.
CN201910104220.1A 2019-02-01 2019-02-01 Plant essence liquid and preparation method thereof and sanitary napkin application Pending CN109602868A (en)

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Publication number Priority date Publication date Assignee Title
CN110124017A (en) * 2019-05-21 2019-08-16 张静 A kind of bacteriostatic gel
CN112107621A (en) * 2020-09-14 2020-12-22 株洲千金药业股份有限公司 Plant essence for preventing bedsore and deodorizing and application thereof

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CN110124017A (en) * 2019-05-21 2019-08-16 张静 A kind of bacteriostatic gel
CN112107621A (en) * 2020-09-14 2020-12-22 株洲千金药业股份有限公司 Plant essence for preventing bedsore and deodorizing and application thereof
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Application publication date: 20190412