CN111759885A - Sophora flavescens composition, sophora flavescens gel and preparation method thereof - Google Patents

Sophora flavescens composition, sophora flavescens gel and preparation method thereof Download PDF

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Publication number
CN111759885A
CN111759885A CN202010649400.0A CN202010649400A CN111759885A CN 111759885 A CN111759885 A CN 111759885A CN 202010649400 A CN202010649400 A CN 202010649400A CN 111759885 A CN111759885 A CN 111759885A
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Prior art keywords
sophora flavescens
essential oil
composition
parts
gel
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于秀华
韦安迪
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Shandong Chuanyun Biotechnology Co ltd
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Shandong Chuanyun Biotechnology Co ltd
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Priority to CN202010649400.0A priority Critical patent/CN111759885A/en
Publication of CN111759885A publication Critical patent/CN111759885A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532Agastache, e.g. giant hyssop
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Abstract

The invention relates to the technical field of daily chemical articles for female hygiene and health, in particular to a sophora flavescens composition, a sophora flavescens gel and a preparation method thereof. The sophora flavescens composition at least comprises the following components in parts by weight: 20-40 parts of natural active substances, 10-30 parts of luba gum, 1-10 parts of active bacteria and 0.5-3 parts of amino acid derivatives; the natural active substance at least comprises sophora flavescens essential oil. The invention also provides a gel containing the sophora flavescens extract, which adopts plant active substances as main raw materials, has no toxicity, no stimulation, no toxic or side effect, obvious curative effect and good comfort after use, and can quickly remove the peculiar smell of the pudendum, resist bacteria, eliminate dampness, clear away heat and toxic materials; in addition, the sophora flavescens gel provided by the invention can maintain the balance and stability of vaginal environment, inhibit the proliferation of pathogenic bacteria, is beneficial to the growth of beneficial bacteria, improves the immunity of vagina, can also improve the psychological state of a user, and relieves anger and anxiety and soothes nerves.

Description

Sophora flavescens composition, sophora flavescens gel and preparation method thereof
Technical Field
The invention relates to the technical field of daily chemical articles for female hygiene and health, in particular to a sophora flavescens composition, a sophora flavescens gel and a preparation method thereof.
Background
The female lower genital tract is an open cavity tract, is an important micro-ecological area in the human body, and is a micro-ecological system mainly composed of dominant bacteria under normal conditions. As women age, the balance environment of the vagina is damaged by sexual life or fertility, vaginal muscle relaxation is caused, and the physical and mental health of the women is affected. Meanwhile, female vaginal microecological imbalance is a main cause causing recurrent attacks of gynecological inflammation, and more women suffer from gynecological inflammation such as abnormal leucorrhea, pudendal pruritus, irregular menstruation, leucorrhea peculiar smell, vaginitis, pelvic inflammation, adnexitis, cervical erosion and the like.
Under normal physiological conditions, estrogen thickens vaginal epithelium and enriches it with glycogen, increasing resistance to pathogens; the glycogen is decomposed into lactic acid under the action of lactobacillus vaginalis, so that the normal acidic environment of the vagina is maintained (the pH is less than or equal to 4.5 and more than 3.8-4.4), the growth of other parasitic bacteria and pathogens thereof is inhibited, and the self-cleaning effect of the vagina is realized. Once broken or invaded by foreign pathogens, inflammation can occur, such as altered estrogen levels or increased vaginal pH; abuse or use of antibiotics can lead pathogenic bacteria to generate drug resistance, kill a large amount of beneficial bacteria and destroy the balance of vaginal flora, thereby causing the fungi to grow vigorously, the gynecological diseases to be stubborn and difficult to be entangled and the thorough radical cure to be difficult.
The gel is a thick liquid or semisolid preparation of emulsion in a uniform, suspension or emulsion form, which is prepared by the medicine and proper auxiliary materials. The gel is topically applied to skin and body cavities such as nasal cavity, vagina and rectum. At present, the types of gels on the market are various, the female pudendum antibacterial gel products are few, the effects of the gels with the functions of bacteriostasis and vaginal environment maintenance are different and the functions are single for quickly removing pudendum peculiar smell, and a lot of gel products have great limitations. Therefore, the sophora flavescens gel provided by the invention has the effects of resisting bacteria, clearing damp, clearing heat, removing toxicity, killing parasites and relieving itching, can quickly inhibit the proliferation of pathogenic bacteria, and can maintain and restore local microecological balance.
Disclosure of Invention
In order to solve the above technical problems, a first aspect of the present invention provides a sophora flavescens composition, which at least comprises the following components in parts by weight: 20-40 parts of natural active substances, 10-30 parts of luba gum, 1-10 parts of active bacteria and 0.5-3 parts of amino acid derivatives; the natural active substance at least comprises sophora flavescens essential oil.
As a preferred technical scheme of the present invention, the natural active substance is a combination of plant extracts and plant essential oils, and the weight ratio is 1: (0.1-1.5).
As a preferred technical scheme of the present invention, the plant extract is a combination of perilla extract, artemisia leaf extract and arbutin extract, and the weight ratio is 1: (1-3): (0.5-2.5).
According to a preferable technical scheme of the invention, the plant essential oil is a combination of cananga odorata essential oil, sophora flavescens essential oil, geranium essential oil, lemon essential oil and patchouli essential oil, and the weight ratio of the cananga odorata essential oil to the sophora flavescens essential oil is 1: (1-5): (0.1-0.5): (0.1-0.5): (0.5-1.5).
As a preferable technical scheme of the invention, the weight ratio of the lubasca gum to the active bacteria is 1: (0.1-1).
In a preferred embodiment of the present invention, the amino acid derivative is an octanoyl amino acid derivative and/or a lauroyl amino acid derivative.
In a preferred embodiment of the present invention, the active bacteria include at least one of lactobacillus and lactobacillus/rice fermentation product.
The second aspect of the invention provides a daily chemical product containing the sophora flavescens composition, and the daily chemical product is in the form of gel, spray, lotion, cream or cream.
The third aspect of the invention provides a sophora flavescens gel, and the preparation raw materials of the sophora flavescens gel comprise, by weight, 50-75% of the sophora flavescens composition, 2-8% of vitamin, 1-5% of humectant, 0.5-3% of thickener, 0.5-3% of pH regulator, and water in balance of 100%.
The fourth aspect of the present invention provides a preparation method of the sophora flavescens gel, which at least comprises the following steps: mixing the radix Sophorae Flavescentis composition, vitamins, humectant, thickener, pH regulator and water.
Advantageous effects
The sophora flavescens composition and the gel prepared from the same can rapidly remove the peculiar smell of the pudendum, resist bacteria, eliminate dampness, clear away heat and toxic materials by compounding the plant essential oil and the plant extract, and adopt plant active substances as main raw materials, so that the sophora flavescens composition is non-toxic, non-irritant, free of toxic and side effects, remarkable in curative effect and good in comfort after being used; in addition, a certain amount of active bacteria are added, so that the vaginal environment can be maintained to be balanced and stable, the growth of beneficial bacteria is facilitated while the proliferation of pathogenic bacteria is inhibited, a good effect on maintaining and restoring local microecological balance is achieved, and the immunity of the vagina is improved; the sophora flavescens composition gel provided by the invention can also improve the psychological state of a user, relieve anger and anxiety and soothe nerves.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the above technical problems, a first aspect of the present invention provides a sophora flavescens composition, which at least comprises the following components in parts by weight: 20-40 parts of natural active substances, 10-30 parts of luba gum, 1-10 parts of active bacteria and 0.5-3 parts of amino acid derivatives; the natural active substance at least comprises sophora flavescens essential oil.
In a preferred embodiment, the sophora flavescens composition at least comprises the following components in parts by weight: 30 parts of natural active substances, 20 parts of luba glue, 10 parts of active bacteria and 2 parts of amino acid derivatives; the natural active substance at least comprises sophora flavescens essential oil.
Natural active substance
In the present invention, as the natural active substance, plant extracts, plant essential oils and the like can be mentioned.
In a preferred embodiment, the natural active is a combination of a plant extract and a plant essential oil.
In a more preferred embodiment, the natural active substance is a plant extract and plant essential oil in a weight ratio of 1: (0.1-1.5).
In a most preferred embodiment, the weight ratio of the plant extract to the plant essential oil is 1: 1.2.
plant extracts
Plant extracts (Plant extracts) refer to substances extracted or processed from plants (whole or a part of plants) by using a suitable solvent or method, and can be used in the pharmaceutical industry, the food industry, the health industry, the beauty industry and other industries. The plant extract is a product formed by taking plants as raw materials, directionally obtaining and concentrating one or more active ingredients in the plants through a physical and chemical extraction and separation process according to the requirements of the application of an extracted final product, and not changing the structures of the active ingredients. According to different components of the extracted plants, glycoside, acid, polyphenol, polysaccharide, terpenoid, flavone, alkaloid and the like are formed; according to different properties, the plant oil can be divided into vegetable oil, extract, powder, crystalline lens and the like.
In the present invention, the plant extract is a combination of perilla extract, artemisia leaf extract and arbutin extract.
In a preferred embodiment, the weight ratio of the perilla extract, the artemisia leaf extract and the arbutin extract is 1: (1-3): (0.5-2.5).
In a more preferred embodiment, the weight ratio of the perilla extract, the artemisia leaf extract and the arbutin extract is 1: 2: 1.5.
perilla extract
The plant source of Perillae herba extract is stem and leaf of Perilla Perillarum (L.) Britt. of Perilla of Labiatae. The leaves are called perilla leaves, the stems are called perilla stems, the perilla leaves are curled and crushed in a multi-fold way, and the edges are provided with circular saw teeth. Purple on both sides, or green on the upper surface and purple on the lower surface, and has grey hair, and concave glandular scales on the lower surface. The leaf stalk is 2-7cm long and purple or purple green. The diameter of the twig is 2-5mm, the twig is purple green, and the middle part of the section is provided with marrow. Fragrant smell, slightly pungent taste.
In the present invention, the source of the perilla extract is not particularly limited, and there may be mentioned, for example, hibiscus biotechnology limited.
Folium Artemisiae Argyi extract
Artemisia vulgaris (academic name: Artemisia argyi H.L ev. & Vaniot) alias: xiaoshi, glacial acetic acid, pennycress, wormwood, Chinese mugwort, bang-ligusticum, mugwort, moxibustion, medicinals, yellow grass, moxa and the like. Perennial herbs or semi-shrubs are formed, and plants have strong fragrance. Stem simple or few, brown or sallowly brown, slightly lignified at the base, with few short branches at the upper part, thick paper of leaves, grayish white short, soft hair at the upper part, usually without or with very small pseudoleaves at the base; the upper leaves and bracts have half-feathered and half-split shape, head-shaped inflorescence is elliptical, the corolla is tubular or high-foot cup-shaped, the exterior has glandular spots, the anther is narrow-line-shaped, and the style is nearly equal to or slightly longer than the corolla. The slim fruit is oblong.
In the present invention, the source of the artemisia argyi extract is not particularly limited, and sanshan national saint biotechnology limited may be mentioned.
Arbutin extract
Arbutin, also known as arbutin, is in the form of white needle crystals or powder. The extract is extracted from the leaves of bearberry, and has effects of inhibiting tyrosinase activity in vivo, preventing melanin generation, reducing skin pigmentation, removing mottle and freckle, killing bacteria, and relieving inflammation. The arbutin is a natural active substance derived from green plants, integrates the harmony of the green plants, the safety and the reliability and the high-efficiency decoloration into a whole, can quickly permeate into the skin, can effectively inhibit the activity of tyrosinase in the skin and block the formation of melanin while not influencing the cell proliferation concentration, accelerates the decomposition and the excretion of the melanin by directly combining with the tyrosinase by self, thereby reducing the pigmentation of the skin, removing color spots and freckles, and does not generate toxic, irritant, sensitizing and other side effects on the melanocyte, and also has the functions of sterilization and inflammation diminishing.
In the present invention, the source of the arbutin extract is not particularly limited, and Somanou Biotech Co., Ltd.
Plant essential oil
The plant essential oil is extracted from flower, leaf, root, bark, fruit, seed, resin, etc. of herbaceous plant by distillation and squeezing. Because the essential oil of the fumigation has high volatility and small molecules, the essential oil is easy to be absorbed by human bodies and can quickly permeate into internal organs of the human bodies to discharge redundant components out of the human bodies, the whole process only needs a few minutes, and the fragrance of the plants directly stimulates the secretion of pituitary gland, the secretion of enzymes, hormones and the like, balances the internal functions of the human bodies, and plays a role in beautifying and protecting the skin. Plant essential oils are composed of over a hundred components, and some more, up to several hundred to thousands, and generally contain alcohols, aldehydes, acids, phenols, propines, and terpenes. In the case of rose essential oil, 86% of the rose essential oil is composed of more than three hundred components, and 14% of the rose essential oil is composed of a plurality of trace compounds, and the composition ratio of the two components is different, so that the taste and the curative effect are influenced. The flos Rosae Rugosae Bulgaria contains 33-55% citronellol, 30-40% geraniol and nerol, 16-22% stearyl alcohol, 1.5-2% phenethyl alcohol, 0.2-2% sesquiterpene cyclic alcohol, and trace amount of synthesis.
In the invention, the plant essential oil is a combination of cananga odorata essential oil, sophora flavescens essential oil, geranium essential oil, lemon essential oil and patchouli essential oil.
In a preferred embodiment, the weight ratio of the ylang essential oil, the sophora flavescens essential oil, the geranium essential oil, the lemon essential oil and the patchouli essential oil is 1: (1-5): (0.1-0.5): (0.1-0.5): (0.5-1.5).
In a more preferred embodiment, the weight ratio of ylang-ylang essential oil, sophora flavescens essential oil, geranium essential oil, lemon essential oil and patchouli essential oil is 1: 3: 0.3: 0.2: 0.9.
ylang essential oil
Cananga oil is an extract from the plant cananga, which is colorless or yellow, fluid, clear, and fragrant and heavy. The shape of the ylang tree is small arbor, the blade is oval, the flower sheet is narrow and fine, the flower color is yellow, pink and violet blue, the essential oil is obtained by distilling the flower, the best light yellow essential oil is extracted from the yellow flower, and the main producing areas are Malaysia, Philippines, Burmese and Australia of southeast Asia.
In the present invention, the source of the cananga essential oil is not particularly limited, and shanghai zixin biotechnology limited may be mentioned.
Radix Sophorae Flavescentis essential oil
Radix Sophorae Flavescentis (academic name: Radix Sophorae Flavescentis) is a plant of Sophora of Leguminosae. Alias: ramulus Et folium Picrasmae, herba Desmodii Japonicae, herba Sophorae Alopecuroidis, semen Cuscutae, JIAOHUA, herba Sophorae Alopecuroidis or caulis Sinomenii. The plant is distributed in Russia, Japan, India, Korea and the south and north provinces of China, grows in the area with the elevation of 1500 meters, mostly grows in hillside, sand, grass slope, shrub forest and the vicinity of the field, and is not artificially introduced and cultivated at present. The main functions are as follows: clear heat and dry dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, and leprosy; can be used for treating trichomonas vaginitis. Radix Sophorae Flavescentis has antibacterial and anti-inflammatory effects, and has effects of inhibiting acne bacillus, Staphylococcus aureus, and Escherichia coli, promoting urination, resisting allergy, relieving pain, relieving asthma, and eliminating phlegm.
In the present invention, the source of the sophora flavescens essential oil is not particularly limited, and there may be mentioned dean seng essential oil limited.
Geranium essential oil
The geranium is 60 cm, the flower is pink, the front end of the leaf is sharp and provided with saw teeth, the essential oil comes from the leaves of the distilled flower, the taste is slightly like rose, so the geranium is often counterfeited as rose essence, but the geranium has lemon flavor respectively under the smell of fine smell. The geranium essential oil contains citronellol, citronellyl formate, terpinene, geranic acid, geraniol, terpineol, citral, menthone and multiple trace mineral elements. The main function of the composition is to regulate the skin, and the active ingredients in the geranium extract have strong affinity with natural organic lipid. The geranium essential oil can relieve pain, astringe and resist bacteria, stretch into scars, enhance the cell defense function, deeply clean the skin, balance sebum secretion, promote the regeneration of skin cells, repair scars and striae gravidarum, is particularly suitable for oily skin and pockmarked skin, and has good relieving and eliminating effects on pockmarks and pockmarks.
In the present invention, the source of the geranium essential oil is not particularly limited, and Hubei Kangchu pure fragrance Co., Ltd can be mentioned.
Lemon essential oil
The lemon has fresh fragrance, and can refresh brain, refresh mind, relieve dysphoria and purify air. The lemon essential oil has strong and fresh smell, light green yellow color and viscous water, and comprises the following main components: limonene, citral, (Biao) geranic acid, citronella oil, camphene and the like. The lemon essential oil can improve circulatory system function, including promoting blood circulation, lowering blood pressure, and stopping nosebleed. It can enhance immune system, purify body, improve digestive system function, decompose cellulite, and treat dyspepsia and constipation. The lemon essential oil has effects of soothing and relieving headache and migraine, and can be used for treating arthritis and rheumatism by synthesizing acidic substances in human body. It also helps to clean acne, greasy skin and hair, and remove dead skin cells. The lemon has fresh fragrance, and can refresh brain, refresh mind, relieve dysphoria and purify air.
In the present invention, the source of the lemon essential oil is not particularly limited, and a healthy people natural perfume oil factory in Jishui county can be mentioned.
Patchouli essential oil
The main active ingredients of the patchouli essential oil comprise patchouli alcohol, patchouli alkene, eugenol, cadinene and the like. The structure of patchouli alkene is similar to azulene in blue chamomile, so that the patchouli alkene also has the same antibacterial and anti-inflammatory effects. A few drops of patchouli essential oil are dripped into hot water for soaking feet, so that the aims of activating blood and meridians and collaterals can be achieved, and the effect of removing beriberi and foot odor can also be achieved.
In the present invention, the source of said patchouli essential oil is not particularly limited, and there may be mentioned the natural perfumery of Xinda, Jishui county.
The female pudendum environment is obviously reduced along with the aging of organisms or the resistance of the female pudendum environment to the outside from various pressures, and in addition, because the pudendum is vermin due to damp and heat, a large amount of bacteria are bred to destroy the ecological balance of the pudendum, so that the aging and the destruction of the vaginal environment are accelerated, pudendum inflammation and peculiar smell are further caused if the pudendum is not treated or treated unreasonably for a long time, and therefore, the female psychological health or the sexual life of couples are greatly influenced. The sophora flavescens composition prepared by using the compound essential oil prepared from the cananga odorata essential oil, the sophora flavescens essential oil, the geranium essential oil, the lemon essential oil and the patchouli essential oil together with the perilla extract, the folium artemisiae argyi extract and the arbutin extract compounded with the plant extracts has the effects of resisting bacteria, removing dampness, clearing heat, detoxifying, killing parasites and relieving itching, can effectively remove peculiar smell especially for female pudendum, can stimulate the activity of functional deep cells, and avoids the recurrence problem. Firstly, the sophora flavescens essential oil is taken as a main component, and the sophora flavescens essential oil and the geranium essential oil, the lemon essential oil and the patchouli essential oil can generate a synergistic function when used together; the sophora flavescens essential oil contains a large amount of matrine, and the matrine can be used for diminishing inflammation of vagina and treating trichomonas and various gynecological inflammations and has excellent and wide application; the geranium essential oil contains active elements such as citronellol, citronellyl formate and menthone, and the limonene compound in the lemon essential oil, and the geranium essential oil and the limonene compound are compounded to have strong affinity to organic lipid and contain high-activity hydrocarbon respectively, active substances contained in the geranium essential oil and the limonene compound can effectively penetrate into a focus, so that the blockage of gaps and pores at the focus can be eliminated, garbage toxin and inflammatory secretion can be eliminated, the blood circulation of vaginal skin can be promoted, the organ recovery activity of hypofunction can be stimulated, the effective absorption of active ingredients such as matrine in the compound essential oil can be promoted, and a virtuous cycle can be formed; the compound purple perilla extract contains a large amount of a plurality of biological active substances such as alpha-linolenic acid, perillaldehyde, eugenol and the like, can permeate cells, increases the fluidity of a membrane, promotes the separation effect of geranium essential oil and lemon essential oil on foreign matters such as garbage toxin and germs, effectively radically cures the attachment of the germs to the vagina, and realizes the effect of quickly and effectively removing the peculiar smell of the vagina.
Luba adhesive
The Lubrajel (Lubrajel) mainly contains the polyglycerol polymethacrylate, and the polyglycerol polymethacrylate forms a unique cage-shaped structure, so that the lubral has the advantages of a water-soluble skin softener and an oil-soluble skin softener, has water locking capacity, is a wetting balancing agent, a water-soluble non-dry lubricant, has excellent moisture retention performance, is widely applied to gel cosmetics, particularly eye care cosmetics, improves the skin feel and the lubricity of products, has good water solubility, and is a transparent moisture retention substrate. The Gemba gum has double moisturizing effects, can be easily absorbed by skin during massage, improves microcirculation, promotes cell metabolism, adjusts skin pH value, effectively regulates oil secretion, and shrinks pores.
In the present invention, the source of the luba adhesive is not particularly limited, and may be mentioned Guangzhou Yutai chemical technology Co.
Active bacterium
The active bacteria are microorganisms, which are classified into beneficial microorganisms and harmful microorganisms due to their different properties and metabolic modes. The active probiotic tablet has the functions similar to SOD ferment, can eliminate oxygen free radicals (free radicals), stop the source of diseases, delay cell aging, activate T cells, decompose nitroso compounds and other organic carcinogens, inhibit the growth of germs, viruses and cancer cells by the principle of benefiting bacteria and inhibiting bacteria, regulate the blood fat level of a human body, reduce the fat deposition of a blood vessel wall, recover the natural self-healing force, enhance and improve the immunologic function, and enable various diseases of the human body to be improved or recovered vividly. Meanwhile, secretion of microorganisms in the 'active probiotics' such as amino acid, active antibacterial small peptide, organic acid, oligomeric polysaccharide, various vitamins, antibiotic substances, antiviral substances, various biochemical enzymes and oxygen (active oxygen is reduced into molecular oxygen) and the like can directly adjust functions of various organs and increase nutrition, so that the microecological balance in vivo is improved.
In the invention, the active bacteria at least comprise at least one of lactobacillus and lactobacillus/rice fermentation products.
In a preferred embodiment, the active bacteria are a combination of lactobacillus and lactobacillus/rice fermentation product.
In a more preferred embodiment, the weight ratio of lactobacillus to lactobacillus/rice fermentation product is 1: (0.1-0.5).
In a most preferred embodiment, the weight ratio of lactobacillus to lactobacillus/rice fermentation product is 1: 0.3.
in the present invention, the source of the lactic acid bacterium is not particularly limited, and Seawatt Biotech, Inc. may be mentioned.
In the present invention, the source of the lactic acid bacterium/rice fermentation product is not particularly limited, and there can be mentioned Wuhan Hua scientific Biotechnology Co., Ltd.
In the invention, the weight ratio of the lumba gum to the active bacteria is 1: (0.1-1).
In a preferred embodiment, the weight ratio of the luba gum to the active bacteria is 1: 0.5.
the sophora flavescens composition disclosed by the invention can achieve the effects of removing the peculiar smell of vaginal inflammation and rapidly inhibiting the proliferation of pathogenic bacteria by compounding the compound essential oil and the plant extract. However, the inventor further finds that the disease can be deeply conditioned and the immunity of the vagina can be improved by adding a proper amount of the luba gum and the active bacteria into the sophora flavescens gel product in the process of research. The inventor thinks that the probable reason is that the ambar has excellent moisturizing and lubricating effects on the epidermis skin and increases the comfort in use, and the lactobacillus/rice fermentation product is rich in various vitamins and proteins and also contains carbohydrate mucilage, so that the lactobacillus/rice fermentation product not only can nourish the epidermis, but also can soften the vaginal wall and promote the cleaning effect of active ingredients in the compound essential oil on garbage toxin and inflammatory secretion; meanwhile, the luba gum is used as a hydrophilic polymer structure, is beneficial to absorption of nutrient components in lactobacillus/rice fermentation products by cells, improves the growth environment of beneficial bacteria, and has a very good promotion effect on maintaining and restoring local microecological environment balance.
Amino acid derivatives
Amino acid derivatives are substances which are synthesized from amino acids by a series of reactions, for example, the combined deamination of amino acids to synthesize amino acid derivatives, i.e., the precursors of amino acid derivatives are amino acids. Various substances in the human body, such as epinephrine and thyroid hormone, are amino acid derivatives.
In the present invention, the amino acid derivative is an octanoyl amino acid derivative and/or a lauroyl amino acid derivative.
In a preferred embodiment, the amino acid derivative is an octanoyl amino acid derivative.
In a more preferred embodiment, the amino acid derivative is caprylylglycine.
In a most preferred embodiment, the amino acid derivative is water-soluble caprylylglycine.
In the present invention, the source of the water-soluble capryloyl glycine is not particularly limited, and Beijing Leisi biochemistry Co.
The inventor finds that the addition of a proper amount of caprylyl glycine has a strong inhibiting effect on staphylococcus aureus, propionibacterium acnes and the like, can inhibit the degradation of elastase, and reduces the vaginal relaxation and aging rate; in addition, the inventor also unexpectedly finds that after a proper amount of caprylyl glycine is added into the gel system, the use comfort of patients can be obviously improved, and the gel system has a function of soothing the spirits of the patients. The inventor believes that a glucose molecule is introduced into the molecule of the arbutin contained in the arbutin extract, which is beneficial to reducing the stimulation effect of the ylang-ylang essential oil on the vaginal wall, and meanwhile, the caprylyl glycine has good affinity on the skin and can promote the absorption of active volatile components such as benzoic acid, muscol and the like and alkaloids such as ylang-ylang, methylmangiferine and the like in the ylang-ylang essential oil; in addition, after the active ingredients are compounded for use, the composition also has the effects of estrus promotion and tranquilization, has excellent effects of relieving pressure and soothing nerves, and enables the cananga odorata essential oil to have high utilization rate under the condition of low content; in addition, the luba glue as a hydrophilic polymer structure can form a fine elastic net film on the vaginal wall, on one hand, the luba glue can firmly lock water and improve the moisture degree of skin, on the other hand, a protective film is formed in the vaginal wall, the pudendum environment is prevented from being damaged by secondary inflammation, and the matrix is given a certain time to restore micro-ecological balance.
In the invention, the preparation method of the sophora flavescens composition comprises the following steps: mixing natural active substance, Gemba gum, active bacteria, and amino acid derivatives.
The second aspect of the invention provides a daily chemical product containing the sophora flavescens composition, and the daily chemical product is in the form of gel, spray, lotion, cream or cream.
The third aspect of the invention provides a sophora flavescens gel, and the preparation raw materials of the sophora flavescens gel comprise, by weight, 50-75% of the sophora flavescens composition, 2-8% of vitamin, 1-5% of humectant, 0.5-3% of thickener, 0.5-3% of pH regulator, and water in balance of 100%.
In a preferred embodiment, the raw materials for preparing the sophora flavescens gel comprise, by weight, 60% of the sophora flavescens composition, 5% of vitamins, 3% of a humectant, 2% of a thickener, 1.5% of a pH regulator, and the balance of water to 100%.
Vitamin preparation
Vitamins are a kind of trace organic substances which must be obtained from food for human and animals to maintain normal physiological functions, and play an important role in the growth, metabolism and development processes of human bodies. Vitamin neurosomes are neither involved in the formation of human cells nor provide energy to the human body.
In the present invention, the vitamin is at least one selected from the group consisting of vitamin a, vitamin B1, vitamin B2, vitamin PP, vitamin B4, vitamin B5, vitamin B6, vitamin B9, vitamin B12, inositol, vitamin D, and vitamin E.
In a preferred embodiment, the vitamins include at least vitamin E.
In the present invention, the source of vitamin E is not particularly limited, and Hippocastanaceae Biotech Co.
Moisture-retaining agent
The moisturizer is a cosmetic raw material with the functions of moisturizing and repairing sebum membranes, and the raw material has a special molecular structure, can adsorb and retain moisture, and maintains the skin barrier function while maintaining the skin hydration.
In the present invention, the humectant is not particularly limited, and polyhydric alcohols, natural moisturizing factors, amino acids, biochemical humectants, and the like can be mentioned.
As the polyhydric alcohol-based moisturizer, glycerin, butylene glycol (butyleneglycol), polyethylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol, sorbitol, and the like can be mentioned.
As the natural moisturizing factor, sodium lactate, urea, and the like can be mentioned.
As the amino acid-based moisturizing agent, vegetable protein, animal protein, hydrolyzed protein, and the like can be mentioned.
As the biochemical humectant, collagen, glycoprotein, hyaluronic acid, chondroitin sulfate, and the like can be mentioned.
In a preferred embodiment, the humectant comprises at least one polyhydric alcohol humectant.
In a more preferred embodiment, the humectant is a combination of glycerin, sorbitol, and chondroitin sulfate.
Thickening agent
The thickener is also called gelatinizer, is a substance capable of increasing the viscosity of latex and liquid, and is also called paste when being used for food. The thickening agent can improve the viscosity of the system, so that the system is kept in a uniform and stable suspension state or an emulsion state, or forms gel; most thickeners combine an emulsifying action. Can be divided into two main categories of natural and synthetic.
In the present invention, the thickener is not particularly limited, and gum arabic, pectin, agar, gelatin, alginate jelly, carrageenan, dextrin, soluble starch, polysaccharide derivative, carboxymethyl cellulose, propylene glycol alginate, methyl cellulose, sodium starch phosphate, sodium carboxymethyl cellulose, sodium alginate, casein, sodium polyacrylate, polyoxyethylene, polyvinyl pyrrolidone, and the like can be mentioned.
pH regulator
Acidity regulators, also known as pH regulators, are substances used to maintain or change the pH of foods. The acidity regulator is obtained by adding alkaline flour after leavening dough. It is mainly used for controlling acidifying agent, alkaline agent and salt with buffer action required by food. Each acidity regulator has different mildness and sourness characteristics.
In the present invention, the pH adjusting agent is not particularly limited, and citric acid, sodium citrate, lactic acid, disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, boric acid, borax, and the like can be mentioned.
Water (W)
In the present invention, the water is not particularly limited, and deionized water, distilled water and the like can be mentioned.
The fourth aspect of the present invention provides a preparation method of the sophora flavescens gel, which at least comprises the following steps: mixing the radix Sophorae Flavescentis composition, vitamins, humectant, thickener, pH regulator and water uniformly.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
Example 1
Embodiment 1 provides a sophora flavescens gel, which comprises 60% of the sophora flavescens composition, 5% of vitamins, 3% of a humectant, 2% of a thickener, 1.5% of a pH regulator and the balance of water to 100% by weight.
The sophora flavescens composition at least comprises the following components in parts by weight: 30 parts of natural active substances, 20 parts of luba glue, 10 parts of active bacteria and 2 parts of amino acid derivatives; the natural active substance is a combination of plant extracts and plant essential oil, and the weight ratio of the natural active substance to the plant essential oil is 1: 1.2; the plant extract is a combination of perilla extract, folium artemisiae argyi extract and arbutin extract, and the weight ratio is 1: 2: 1.5; the perilla extract was purchased from downy stonite biotechnology limited; the folium artemisiae argyi extract is purchased from saint biotechnology limited of Shaanxi country; the arbutin extract is purchased from Sophia superior Biotech, Inc.; the plant essential oil is a combination of cananga odorata essential oil, sophora flavescens essential oil, geranium essential oil, lemon essential oil and patchouli essential oil, and the weight ratio is 1: 3: 0.3: 0.2: 0.9; the cananga odorata essential oil is purchased from Shanghai Yangxin Biotech limited; the sophora flavescens essential oil is purchased from Ji' an Sheng big perfume oil Co., Ltd; the geranium essential oil is purchased from Hubei province Kangchun pure spice company Limited; the lemon essential oil is purchased from natural spice oil factories of Jianmin in Jishui county; the patchouli essential oil is purchased from Xinda natural perfumery in Jishui county; the luba adhesive is purchased from Guangzhou Yutai chemical technology Co., Ltd; the active bacteria are a combination of lactobacillus and lactobacillus/rice fermentation products, and the weight ratio is 1: 0.3; the lactobacillus is purchased from Xiandongite Biotechnology, Inc.; the lactobacillus/rice fermentation product is purchased from Wuhan scientific & specialty Biotech limited; the amino acid derivative is water-soluble capryloyl glycine, purchased from Beijing Bellesce Biochemical Co.
The vitamin is vitamin E and is purchased from Hiden Aicai Biotechnology Limited; the humectant is a combination of glycerol, sorbitol and chondroitin sulfate, and the weight ratio is 1: 1: 1; the thickening agent is hydroxymethyl cellulose; the pH regulator is citric acid; the water is deionized water.
The preparation method of the sophora flavescens gel comprises the following steps: mixing the radix Sophorae Flavescentis composition, vitamins, humectant, thickener, pH regulator and water uniformly.
Example 2
Embodiment 2 provides a sophora flavescens gel, which comprises, by weight, 50% of the sophora flavescens composition, 2% of vitamins, 1% of a humectant, 0.5% of a thickener, 0.5% of a pH regulator, and water to 100%.
The sophora flavescens composition at least comprises the following components in parts by weight: 20 parts of natural active substances, 10 parts of luba glue, 1 part of active bacteria and 0.5 part of amino acid derivatives; the natural active substance is a combination of plant extracts and plant essential oil, and the weight ratio of the natural active substance to the plant essential oil is 1: 0.1; the plant extract is a combination of perilla extract, folium artemisiae argyi extract and arbutin extract, and the weight ratio is 1: 1: 0.5; the perilla extract was purchased from downy stonite biotechnology limited; the folium artemisiae argyi extract is purchased from saint biotechnology limited of Shaanxi country; the arbutin extract is purchased from Sophia superior Biotech, Inc.; the plant essential oil is a combination of cananga odorata essential oil, sophora flavescens essential oil, geranium essential oil, lemon essential oil and patchouli essential oil, and the weight ratio is 1: 1: 0.1: 0.1: 0.5; the cananga odorata essential oil is purchased from Shanghai Yangxin Biotech limited; the sophora flavescens essential oil is purchased from Ji' an Sheng big perfume oil Co., Ltd; the geranium essential oil is purchased from Hubei province Kangchun pure spice company Limited; the lemon essential oil is purchased from natural spice oil factories of Jianmin in Jishui county; the patchouli essential oil is purchased from Xinda natural perfumery in Jishui county; the luba adhesive is purchased from Guangzhou Yutai chemical technology Co., Ltd; the active bacteria are a combination of lactobacillus and lactobacillus/rice fermentation products, and the weight ratio is 1: 0.1; the lactobacillus is purchased from Xiandongite Biotechnology, Inc.; the lactobacillus/rice fermentation product is purchased from Wuhan scientific & specialty Biotech limited; the amino acid derivative is water-soluble capryloyl glycine, purchased from Beijing Bellesce Biochemical Co.
The vitamin is vitamin E and is purchased from Hiden Aicai Biotechnology Limited; the humectant is a combination of glycerol, sorbitol and chondroitin sulfate, and the weight ratio is 1: 1: 1; the thickening agent is hydroxymethyl cellulose; the pH regulator is citric acid; the water is deionized water.
The preparation method of the sophora flavescens gel comprises the following steps: mixing the radix Sophorae Flavescentis composition, vitamins, humectant, thickener, pH regulator and water uniformly.
Example 3
Embodiment 3 provides a sophora flavescens gel, which comprises 75% of the sophora flavescens composition, 8% of vitamin, 5% of humectant, 3% of thickener, 3% of pH regulator and the balance of water to 100% by weight.
The sophora flavescens composition at least comprises the following components in parts by weight: 40 parts of natural active substances, 30 parts of luba glue, 10 parts of active bacteria and 3 parts of amino acid derivatives; the natural active substance is a combination of plant extracts and plant essential oil, and the weight ratio of the natural active substance to the plant essential oil is 1: 1.5; the plant extract is a combination of perilla extract, folium artemisiae argyi extract and arbutin extract, and the weight ratio is 1: 3: 2.5; the perilla extract was purchased from downy stonite biotechnology limited; the folium artemisiae argyi extract is purchased from saint biotechnology limited of Shaanxi country; the arbutin extract is purchased from Sophia superior Biotech, Inc.; the plant essential oil is a combination of cananga odorata essential oil, sophora flavescens essential oil, geranium essential oil, lemon essential oil and patchouli essential oil, and the weight ratio is 1: 5: 0.5: 0.5: 1.5; the cananga odorata essential oil is purchased from Shanghai Yangxin Biotech limited; the sophora flavescens essential oil is purchased from Ji' an Sheng big perfume oil Co., Ltd; the geranium essential oil is purchased from Hubei province Kangchun pure spice company Limited; the lemon essential oil is purchased from natural spice oil factories of Jianmin in Jishui county; the patchouli essential oil is purchased from Xinda natural perfumery in Jishui county; the luba adhesive is purchased from Guangzhou Yutai chemical technology Co., Ltd; the active bacteria are a combination of lactobacillus and lactobacillus/rice fermentation products, and the weight ratio is 1: 0.5; the lactobacillus is purchased from Xiandongite Biotechnology, Inc.; the lactobacillus/rice fermentation product is purchased from Wuhan scientific & specialty Biotech limited; the amino acid derivative is water-soluble capryloyl glycine, purchased from Beijing Bellesce Biochemical Co.
The vitamin is vitamin E and is purchased from Hiden Aicai Biotechnology Limited; the humectant is a combination of glycerol, sorbitol and chondroitin sulfate, and the weight ratio is 1: 1: 1; the thickening agent is hydroxymethyl cellulose; the pH regulator is citric acid; the water is deionized water.
The preparation method of the sophora flavescens gel comprises the following steps: mixing the radix Sophorae Flavescentis composition, vitamins, humectant, thickener, pH regulator and water uniformly.
Example 4
Example 4 differs from example 1 in that the plant essential oil does not include sophora flavescens essential oil.
Example 5
Example 5 differs from example 1 in that the plant essential oil does not comprise geranium essential oil.
Example 6
Example 6 differs from example 1 in that the plant essential oil does not comprise lemon essential oil.
Example 7
Example 7 differs from example 1 in that the plant essential oil does not include cananga odorata essential oil.
Example 8
Example 8 differs from example 1 in that the plant extract does not include perilla extract.
Example 9
Example 9 differs from example 1 in that the plant extract does not include an arbutin extract.
Example 10
Example 10 differs from example 1 in that no guava gum is included.
Example 11
Example 11 differs from example 1 in that no active bacteria are included.
Example 12
Example 12 differs from example 1 in that the active bacterium is a lactic acid bacterium.
Example 13
Example 13 differs from example 1 in that the lactobacillus/rice fermented product is replaced with a lactic acid bacteria fermented product.
Example 14
Example 14 differs from example 1 in that no amino acid derivative is included.
Example 15
Example 15 differs from example 1 in that the amino acid derivative is lauroyl glycine.
Performance testing
1. And (3) microbial detection: the sophora flavescens gel obtained in example 1 was subjected to microbiological examination according to the method specified in "hygienic standard for disposable use GB 15979-2002", and the results were as follows, and whether or not the gel meets the criteria shown in table 1, and the results were all satisfactory.
TABLE 1. microbiological test results of Sophora flavescens gel obtained in example 1
Item Results
Total bacterial colony count (cfu/g) <4
Escherichia coli Not detected
Pseudomonas aeruginosa Not detected
Staphylococcus aureus Not detected
Hemolytic streptococcus Not detected
Total fungal colony count (cfu/g) <4
2. And (3) safety testing: the sophora flavescens gel prepared in example 1 was subjected to safety inspection according to the requirements of "quality control regulations for non-clinical research on drugs" on 9/1 of 2003, which was performed by the national food and drug administration. In particular to the implementation of the method which follows the national food and drug administration 'technical guidance principle of research on irritation, allergy and hemolysis of chemical drugs'.
The result shows that the gynecological gel prepared in the embodiment 1 of the invention has no irritation to the skin within 7 days, which indicates that the sophora flavescens gel provided by the invention has higher safety.
3. Efficacy and feeling of use test:
(1) test samples: the sophora flavescens gel prepared in examples 1 and 4 to 15;
(2) test subjects: 260 female patients with different degrees of gynecological inflammation had the following main symptoms: pruritus vulvae or burning sensation, and more, sticky and peculiar smell of leucorrhea;
(3) the test method comprises the following steps: subjects were randomly divided into 13 groups of 20 persons each, designated as example 1 group and examples 4-15 groups, and applied with the gynecological gel prepared in example 1 and examples 4-15, respectively. All the medicines are injected into vagina by adopting a special container, the medicine is kept for more than 20min, the medicine is taken once every night, and 7 days are a treatment course. After 3 treatment courses, the effect was counted.
Wherein, the efficacy judgment standard is as follows: effectively, the symptoms are obviously improved, the vulva has no pruritus or burning sensation, the leucorrhea is normal, transparent and odorless; the ineffectiveness refers to no obvious change of symptoms, pruritus vulvae or burning sensation, large amount of leucorrhea, viscosity and peculiar smell;
use feeling judgment criteria: preferably, no discomfort is caused in the using process; the discomfort of skin irritation, sticky feeling and the like can be caused in the using process.
The test results are shown in Table 2.
TABLE 2 efficacy and feeling of use test results
Figure BDA0002574328490000181
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims (10)

1. The sophora flavescens composition is characterized by at least comprising the following components in parts by weight: 20-40 parts of natural active substances, 10-30 parts of luba gum, 1-10 parts of active bacteria and 0.5-3 parts of amino acid derivatives; the natural active substance at least comprises sophora flavescens essential oil.
2. The sophora flavescens composition as claimed in claim 1, wherein the natural active substance is a combination of plant extract and plant essential oil, in a weight ratio of 1: (0.1-1.5).
3. The sophora flavescens composition as claimed in claim 2, wherein the plant extract is a combination of perilla extract, artemisia leaf extract and arbutin extract in a weight ratio of 1: (1-3): (0.5-2.5).
4. The sophora flavescens composition according to claim 2, wherein the plant essential oil is a combination of cananga oil, sophora flavescens essential oil, geranium essential oil, lemon essential oil and patchouli essential oil in a weight ratio of 1: (1-5): (0.1-0.5): (0.1-0.5): (0.5-1.5).
5. The sophora flavescens composition according to claim 1, wherein the weight ratio of the guava gum to the active bacteria is 1: (0.1-1).
6. The sophora flavescens composition according to claim 1, wherein the amino acid derivative is an octanoyl amino acid derivative and/or a lauroyl amino acid derivative.
7. The sophora flavescens composition as claimed in claim 1, wherein the active bacteria comprise at least one of lactobacillus and lactobacillus/rice fermentation product.
8. A daily chemical product comprising the sophora flavescens composition as claimed in any one of claims 1 to 7, wherein the daily chemical product is in the form of gel, spray, lotion, cream or cream.
9. A sophora flavescens gel is characterized in that the sophora flavescens gel is prepared from 50-75% of the sophora flavescens composition according to any one of claims 1-7, 2-8% of vitamin, 1-5% of humectant, 0.5-3% of thickener, 0.5-3% of pH regulator and water in balance of 100% by weight.
10. The process for preparing the sophora flavescens gel as claimed in claim 9, which comprises at least the following steps: mixing the Sophora flavescens composition of any one of claims 1 to 7, vitamins, humectant, thickener, pH regulator and water uniformly.
CN202010649400.0A 2020-07-08 2020-07-08 Sophora flavescens composition, sophora flavescens gel and preparation method thereof Withdrawn CN111759885A (en)

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CN114177132A (en) * 2021-12-13 2022-03-15 湖北艾艾贴健康科技有限公司 Foot bath gel containing folium Artemisiae Argyi extract
CN114762702A (en) * 2021-05-11 2022-07-19 山东华中生物科技有限公司 Sophora flavescens gel and preparation method and application thereof
CN114762652A (en) * 2021-05-10 2022-07-19 山东华中生物科技有限公司 Vaginal gel and preparation method thereof

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* Cited by examiner, † Cited by third party
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CN114762652A (en) * 2021-05-10 2022-07-19 山东华中生物科技有限公司 Vaginal gel and preparation method thereof
CN114762652B (en) * 2021-05-10 2024-04-09 山东华中生物科技有限公司 Vaginal gel and preparation method thereof
CN114762702A (en) * 2021-05-11 2022-07-19 山东华中生物科技有限公司 Sophora flavescens gel and preparation method and application thereof
CN114762702B (en) * 2021-05-11 2024-04-05 山东华中生物科技有限公司 Sophora flavescens ait gel and preparation method and application thereof
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Application publication date: 20201013