CN108158869B

CN108158869B - Antibacterial wet tissue liquid, wet tissue and preparation method of wet tissue

Info

Publication number: CN108158869B
Application number: CN201810185916.7A
Authority: CN
Inventors: 吴启锡; 洪宗本
Original assignee: Sichuan Cypress Biological Technology Co ltd
Current assignee: Sichuan Cypress Biological Technology Co ltd
Priority date: 2018-03-07
Filing date: 2018-03-07
Publication date: 2021-04-30
Anticipated expiration: 2038-03-07
Also published as: CN108158869A

Abstract

The invention relates to a hygienic product, and in particular relates to an antibacterial wet tissue liquid, a wet tissue and a preparation method thereof. The bacteriostatic wet tissue liquid is characterized by at least comprising the following components in parts by weight: 15-20 parts of deionized water, 70-80 parts of cedar hydrolat, 0.001-0.015 part of cedar essential oil, 2-7 parts of humectant, 0.5-3 parts of skin conditioner and 0.003-0.02 part of solubilizer.

Description

Antibacterial wet tissue liquid, wet tissue and preparation method of wet tissue

Technical Field

The invention relates to a hygienic product, and in particular relates to an antibacterial wet tissue liquid, a wet tissue and a preparation method thereof.

Background

The wet tissue is a common sanitary product and is prepared by soaking various wet tissue liquids in a flexible flaky carrier. A large amount of chemical bacteriostatic agents such as quaternary ammonium salts including cetylpyridinium chloride, benzalkonium chloride and the like are added into wet tissues in the market at present, researches show that the quaternary ammonium salts have high toxicity and irritation on cations, and the long-term use of one cationic bactericide in the same system can possibly cause certain harmful microorganisms to generate drug resistance. Such as benzalkonium chloride bactericide, may result in increased drug resistance of pseudomonas aeruginosa. Also, chemical preservatives such as formaldehyde, methylchloroisothiazolinone, methylisothiazolinone, and the like, have been added to wet wipes. The formaldehyde can achieve the antiseptic effect by creating an environment which is not suitable for the survival of microorganisms. Although formaldehyde in cosmetics and daily sanitary products hardly enters human bodies, when the contact amount exceeds the normal metabolic amount, the formaldehyde can enter human blood and has toxic effects on kidneys, livers, hematopoietic tissues and the like, so that a plurality of systems are damaged. Methylisothiazolinone (MIT) may present a potential risk of causing skin irritation. Methylchloroisothiazolinone (CMIT) belongs to a strong allergen. The use of these wet wipes is not only inconvenient for people, but also may cause strong skin irritation, which in turn causes allergies and more serious skin injuries.

Aiming at the technical problems, the invention provides the bacteriostatic wet tissue which takes the natural plant extract as the bacteriostatic active component, has no stimulation to skin and low sensitization rate, and can better meet the demand of the bacteriostatic wet tissue in the market.

Disclosure of Invention

In order to solve the technical problems, the first aspect of the invention provides a bacteriostatic wet tissue liquid, which at least comprises the following components in parts by weight: 15-20 parts of deionized water, 70-80 parts of cedar hydrolat, 0.001-0.015 part of cedar essential oil, 2-7 parts of humectant, 0.5-3 parts of skin conditioner and 0.003-0.02 part of solubilizer.

In a preferred embodiment of the present invention, the humectant is one or more selected from the group consisting of small molecular weight polyols, plant polysaccharide humectants, and amino acid humectants.

In a preferred embodiment of the present invention, the humectant is a small-molecular polyol selected from any one or more of 1, 3-propanediol, glycerol, 1, 3-butanediol, methylpropanediol, 1, 2-pentanediol, 3-methyl-1, 3-butanediol, 1, 2-hexanediol, diglycerol, dipropylene glycol, sorbitol, 1, 2-octanediol, p-hydroxyacetophenone, and D-panthenol.

As a preferable technical scheme of the invention, the skin conditioning agent is selected from any one or more of allantoin, ceramide, beta-glucan, babassu seed oil glycerol polyether-8 esters and compound plant anti-allergy agents.

According to a preferable technical scheme, the skin conditioner is a mixture of allantoin, babassu seed oil glyceryl polyether-8 esters and a composite plant anti-allergy agent, wherein the mass ratio of the allantoin to the babassu seed oil glyceryl polyether-8 esters to the composite plant anti-allergy agent is (1-3): 5: 3.6 to 5.

As a preferred technical scheme of the invention, the solubilizer is selected from any one or more of PEG-20 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil and Tween-80.

According to a preferable technical scheme of the invention, the bacteriostatic wet tissue liquid further comprises an auxiliary agent, the mass fraction of the auxiliary agent in the bacteriostatic wet tissue liquid is lower than 0.3%, and the auxiliary agent is selected from any one or more of a thickening agent, a chelating agent and a pH regulator.

The second aspect of the invention provides a preparation method of the bacteriostatic wet tissue liquid, which at least comprises the following steps:

adding deionized water, cypress hydrolat and humectant into a preparation pot, heating to 80 ℃, and uniformly stirring at 25 Hz; cooling to 40 deg.C, adding skin conditioner, and stirring at 25 Hz; adding the rest raw materials into a preparation pot, and stirring at 25Hz until the mixture is uniform; filtering with 200-mesh filter cloth to obtain the bacteriostatic wet tissue liquid.

The third aspect of the invention provides an antibacterial wet tissue which comprises a flexible flaky fiber carrier, wherein the flexible flaky fiber carrier is saturated with the antibacterial wet tissue liquid.

As a preferable technical scheme of the invention, the flexible flaky fiber carrier is spunlace non-woven fabric, cotton cloth or paper towel.

The above-described and other features, aspects, and advantages of the present application will become more apparent with reference to the following detailed description.

The bacteriostatic wet tissue disclosed by the invention is stable in liquid quality, transparent in solution, unlikely to generate turbidity, and good in anti-inflammatory and antibacterial effects.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

"Polymer" means a polymeric compound prepared by polymerizing monomers of the same or different types. The generic term "polymer" embraces the terms "homopolymer", "copolymer", "terpolymer" and "interpolymer".

"interpolymer" means a polymer prepared by polymerizing at least two different monomers. The generic term "interpolymer" includes the term "copolymer" (which is generally used to refer to polymers prepared from two different monomers) and the term "terpolymer" (which is generally used to refer to polymers prepared from three different monomers). It also includes polymers made by polymerizing four or more monomers. "blend" means a polymer formed by two or more polymers being mixed together by physical or chemical means.

As a preferable technical scheme of the invention, the bacteriostatic wet tissue liquid at least comprises the following components in parts by weight: 18.70 parts of deionized water, 75 parts of cypress hydrolat, 0.005 part of cypress essential oil, 4 parts of humectant, 1.2 parts of skin conditioner and 0.01 part of solubilizer.

The cypress in the invention refers to cypress (27097), wherein the cypress (Sabina chinensis (L.) Ant.) refers to the cypress (27097), is a plant belonging to the subnata of Cunninghamia, Cupressaceae and Thuja, is an evergreen tree, and has a tip tower shape or a conical shape of a crown, and an old tree is wide in egg shape. The 2-leaf sprout, the spiny branch of the sapling or base is mostly triangular diamond shape, 3-leaf rotation grows, the base has joint and grows downwards; most old trees are scaly leaves, are opposite and are closely attached to twigs; there are also plants that are all diamond-shaped leaves from the young. The flowers are female and male, male globeflower is formed in autumn, the flowers are open in the next year, and the flowers are yellow; the female cone has small shape, the cone is mature next year, the berry shape does not crack, and the outer surface is white powder. The Xiguang tree species is fond of warm and cool, warm climate and moist soil, is compact and hard, and can be used for pencils, furniture and building materials; juniper is widely distributed in inner Mongolia Wula mountain, Hebei, Shanxi, Shandong, Jiangsu, Zhejiang, Fujian, Anhui, Jiangxi, Henan, southern Shaanxi, southern Gansu, Sichuan, Western Hubei, Hunan, Guizhou, Guangdong, northern Guangxi and Yunnan. Tibet is also cultivated. There are distributions in korea and japan. Cypress used in the invention is produced in Sichuan.

Cypress hydrolat

The hydrolat is also called water essential oil and flower water, and refers to a 100% saturated distillation stock solution separated during the extraction of essential oil in the distillation extraction process, which is a byproduct of essential oil, and has natural and pure components and light and pleasant fragrance. The cedar hydrolat contains a small amount of essential oil components, and also contains all water-soluble components (such as tannic acid, flavonoid, lodine acid, fendorin, cedrol (cedrol and cedrol), cedrene, thujopsirene, longifolene and cedrene) in cedar plants, and the content of 49 components can be achieved through deep detection. Its low concentration is easy to be absorbed by skin, and has no essence and alcohol component, and is mild and non-irritating. The cedar hydrolat also has the following advantages: 1. improving environmental sanitation, eliminating odor, decomposing second-hand smoke and purifying air. 2. Enhancing body resistance, preventing diseases and lowering hypertension. 3. Improving respiratory tract, and relieving asthma and allergic rhinitis. 4. Mosquito and insect killing, antibacterial and mite killing. 5. Balancing hormone, activating cell, and preventing aging. 6. The Chinese medicinal composition can relieve anxiety, relieve stress, insomnia and headache, and is pleasant to the mind. 7. Refreshing brain, improving sub-health constitution, etc.

The cypress pure dew adopts 100 percent of cypress (27097) roots as raw materials, wherein the cypress (27097) roots come from Sichuan province, and the roots which are cut in the past generation of the calendar are used as the raw materials. The production process comprises the following steps: pulverizing the raw materials, and extracting by steam distillation to obtain saturated distilled water stock solution rich in 100% oil during the process of extracting cedar essential oil.

Cypress essential oil

The essential oil is extracted from flower, leaf, root, bark, fruit, seed, resin, etc. of herbaceous plant by distillation and squeezing. Because the essential oil of the fumigation has high volatility and small molecules, the essential oil is easy to be absorbed by human bodies and can quickly permeate into internal organs of the human bodies to discharge redundant components out of the human bodies, the whole process only needs a few minutes, and the fragrance of the plants directly stimulates the secretion of pituitary gland, the secretion of enzymes, hormones and the like, balances the internal functions of the human bodies, and plays a role in beautifying and protecting the skin. The cedar essential oil is prepared by taking 100% of cypress Maki tree root as a raw material, crushing the raw material, and then adopting a water vapor distillation extraction technology for production and extraction. The essential oil of cedar wood contains 22 terpenoids (93.54% of the total amount) (including 7 monoterpenes (9.05%), and 15 sesquiterpenes (84.49%); 5 aliphatic components account for 5.28%; 1 aromatic component, accounting for 1.17%. Comprises (+) -cedrene, thujoram, alpha-cedrene, (+) -thujene, alpha-curcumene, i-caryophyllene, beta-cedrene, (+) -beta-cedrene, alpha-eucalyptol, (+) -alpha-longifolene, (+) -longifolene, (-) -isocaryophyllene, myrcene D, (+) -valencene, p-cymene, 1,3, 5-trimethylcyclohexene, 2,3,4, 5-tetramethyl-2-cyclopentenone, lupxene, (-) -alpha-celery ene, cuminol, bergamotene, (1R) - (+) -CISpinene, 1, 3-trimethylcyclohexane, isolongifolanone, alpha-farnesene, Methyl 2-methoxybenzoate, cis-beta-guaialene, androstenone, and the like.

Cedrol in cedar essential oil is sesquiterpene alcohol with a high boiling point, the boiling point of the sesquiterpene alcohol is 294 ℃, and the cedrol has wide pharmacological effects, such as anti-inflammation, antibiosis, sedation, spasmolysis, cardiovascular disease resistance, anti-aging, anti-tumor and the like. The current research shows that the cedar essential oil has high sensitive bacteriostatic effect on salmonella and bacillus subtilis, and also has bacteriostatic effect with medium sensitive strength on escherichia coli, enterobacter hophallii, klebsiella and bacillus anthracis. Meanwhile, the cypress essential oil is used for treating DPPH, OH,

All have strong scavenging effect and show strong oxidation resistance.

The preparation method of the cedar hydrolat and cedar essential oil at least comprises the following steps:

a. cleaning tree roots of the cedar 27097, removing impurities such as surface sandy soil and the like, drying until the water content is lower than 10%, crushing by a crusher to 10-30 meshes, and filling the crushed materials into the middle part of a distillation tank;

b. generating 100 ℃ water vapor in a vapor generator, entering from a steam inlet at the lower part of a distillation retort, contacting with a filled raw material of cypress Maki, starting an oil pump after 50s, vacuumizing and generating negative pressure of 40 kPa;

c. after the air pressure is stable, the wood raw materials such as the roots of the cypress 27097are fully contacted with the water by spraying normal-temperature water at the top of the distillation retort for cooling, reducing the pressure and humidifying, so that volatile components such as essential oil in the raw material tissues are extracted and mixed by steam under the condition of less pyrolysis and hydrolysis;

and d.30min later, closing the oil pump, naturally pressurizing to the same atmospheric pressure as the outside, opening a steam pipeline above the distillation tank, and connecting a snake-shaped condenser. Condensing steam, decolorizing the obtained liquid with active carbon in a constant temperature oil-water separator, separating oil phase and water phase, filtering to remove impurities to obtain oil phase of cedar essential oil and water phase of cedar hydrolat.

The cypress hydrolat and the cypress essential oil are used simultaneously, so that the beneficial effects of the cypress can be further exerted, but the cypress hydrolat and the cypress essential oil are simultaneously used, so that the stability of the bacteriostatic wet tissue liquid is easily reduced, and the phenomena of turbidity and the like are easily caused at a slightly high or low temperature. The inventor finds that the phenomenon of stability reduction can be avoided by using cedar and shaddock peel essential oil instead of cedar essential oil, and the anti-inflammatory and antibacterial effects of the system can be further enhanced by using the cedar and shaddock peel essential oil.

Mature fruit of Citrus grandis of Rutaceae is produced in southern areas such as Fujian, Jiangxi, Guangdong, Guangxi, etc. of China. The pomelo is fragrant, sour, sweet, bright and moist, rich in nutrition and high in medicinal value, is one of the favorite fruits of people, and is also the most beneficial fruit with dietary therapy benefit acknowledged by the medical field. At present, the pomelo is mainly eaten fresh, and a small part of the pomelo is used for processing. A large amount of shaddock peels are discarded as garbage at will every year, so that resources are wasted and the environment is polluted. The shaddock peel accounts for 54-55% of the total weight of the shaddock, contains various active ingredients, such as naringin, pectin, essential oil, pigment, vitamin B, C, organic acid, higher alcohol and the like, has higher health-care and medicinal values, and is a good raw material for sterilizing, diminishing inflammation, beautifying and protecting skin.

As a preferable technical scheme of the invention, the bacteriostatic wet tissue liquid at least comprises the following components in parts by weight: 15-20 parts of deionized water, 70-80 parts of cypress hydrolat, 0.001-0.015 part of cypress and shaddock peel essential oil, 2-7 parts of humectant, 0.5-3 parts of skin conditioner and 0.003-0.02 part of solubilizer.

As a preferable technical scheme of the invention, the bacteriostatic wet tissue liquid at least comprises the following components in parts by weight: 18.70 parts of deionized water, 75 parts of cypress hydrolat, 0.005 part of cypress and shaddock peel essential oil, 4 parts of humectant, 1.2 parts of skin conditioner and 0.01 part of solubilizer.

As a preferable technical scheme, the preparation method of the cedar and shaddock peel essential oil at least comprises the following steps:

drying the cedar wood and the shaddock peel until the water content is lower than 10%, respectively crushing the cedar wood and the shaddock peel to be below 100 meshes according to the weight ratio of 1: weighing cypress powder and shaddock peel powder 0.1-0.3, adding 5-10 times of ethanol, soaking for 2-3 h, extracting for 2-3 times by microwave heating, filtering, and recovering the solvent to obtain the cedar and shaddock peel essential oil.

Moisture-retaining agent

Moisturizers are hydrophilic skin moisturizing substances that have the ability to bind water in the lower humidity range, moisturize the skin, and they can help maintain the skin in a more than normal equilibrium moisture content by controlling the exchange of moisture between the product and the surrounding air, and thus, reduce skin dryness. Humectants, which may be mentioned: small molecular weight polyol, plant polysaccharide humectant, amino acid humectant, etc.

The small-molecule polyol refers to an alcohol containing 2-9 carbon atoms and two or more hydroxyl groups, and the small-molecule polyol is not limited, and can be exemplified by: 1, 3-propanediol, glycerol, 1, 3-butanediol, 2-methyl-1, 3-propanediol, 1, 2-pentanediol, 3-methyl-1, 3-butanediol, 1, 2-hexanediol, diglycerol, dipropylene glycol, sorbitol, 1, 2-octanediol, p-hydroxyacetophenone, D-panthenol, and the like.

The polysaccharide humectant comprises hyaluronic acid, chitin and derivatives thereof, plant polysaccharide, heparin and the like, and can be listed as follows: hyaluronic acid, sodium hyaluronate, chitosan, heparin, tremella polysaccharide, trehalose, cactus polysaccharide, astragalus polysaccharide, lycium barbarum polysaccharide, sugarcane polysaccharide, honeysuckle polysaccharide, tea polysaccharide and the like.

Examples of the amino acid-based moisturizer include betaine and the like.

Methyl propylene glycol

Methyl propylene glycol, CAS: 2163-42-0, abbreviated as MPO, which is a competitive polyol substitute, is derived from plants, has a stronger moisturizing effect than 1, 3-butanediol and propylene glycol, is fresher than glycerin, provides excellent skin feel and moisturizing effect, is almost non-toxic, has no irritation to skin and eyes, and is approved by FDA. Can be used as an essence synergist and a solubilizer and has good antibacterial property.

The methyl propylene glycol of the present invention was purchased from Bisheng commerce, Inc., Guangzhou, brand DUBOIS, model DUB DIOL.

As a preferable technical scheme of the invention, the skin conditioner is a mixture of allantoin, babassu seed oil glyceryl polyether-8 esters and a composite plant anti-allergy agent, wherein the mass ratio of the allantoin to the babassu seed oil glyceryl polyether-8 esters to the composite plant anti-allergy agent is 2: 5: 5.

allantoin

Allantoin, formula C₄H₆O₃N₄CAS: 97-59-6, also known as 5-urethyllactam, ureidoacetolactam, ureidohydantoin and uretidione, are hydantoin derivatives. At present, the annual production capacity of allantoin in the world is about 5 million tons, and the market demand mainly comprises three fields of medicine, cosmetics and agriculture.

Allantoin, pure product, is a non-toxic, tasteless, non-irritant and non-allergenic white crystal, has the physiological functions of promoting cell growth, accelerating wound healing, softening keratin and the like, and is a good healing agent and anti-ulcer agent for skin wounds. Can be used for relieving and treating xeroderma, scaling skin diseases, skin ulcer, digestive tract ulcer and inflammation, and has good therapeutic effect on osteomyelitis, diabetes, liver cirrhosis, and acne. The allantoin is an amphoteric compound, can be combined with various substances to form a double salt, has the effects of shading light, sterilizing, preventing corrosion, relieving pain and resisting oxidation, can keep the skin moisture, moisten and soften, is a special additive for cosmetics such as beauty and hairdressing, and is widely used as an additive for freckle cream, acne liquid, shampoo, perfumed soap, toothpaste, shaving lotion, hair care agent, astringent, anti-sweat deodorant lotion and the like. The cosmetic containing allantoin has tissue protecting, hydrophilic, water absorbing, and moisture diffusion preventing effects; hair cream, hair cream and shampoo containing allantoin can protect hair and prevent hair from bifurcation and break hair; the lipstick and facial cream containing allantoin can make skin and lip soft and elastic, and have beautiful luster. Allantoin promotes tissue growth, cell metabolism, and softens stratum corneum protein.

Allantoin according to the invention was purchased from imperial groups of the netherlands.

Babesia seed oil glyceryl polyether-8 esters

The babassu seed oil glyceryl polyether-8 esters can obviously improve the activity of superoxide dismutase (SOD) in erythrocytes, delay the aging of organisms, keep moisture and improve the skin protection capability. Meanwhile, the babassu seed oil glycerin not only has the effects of lubricating and moistening the nutrient sebum and regulating and increasing the skin elasticity, but also can obviously reduce the generation amount of substances causing allergy, namely the leukotriene and the intermediate platelet aggregation activation factor (PAF), wherein the rosmarinic acid is contained and is a fenamic acid compound, has the activities of anticoagulation, antibiosis, antiphlogosis, antivirus and the like, and has strong inoxidizability and inhibition of anaphylactic reaction. When the concentration of the babassu seed oil glyceryl polyether-8 ester in the solution reaches a certain critical value (namely critical micelle concentration CMC) and exceeds the critical value, molecules of the babassu seed oil glyceryl polyether-8 ester automatically associate into aggregate particle particles with colloid sizes, and the colloid particles are in an equilibrium state to form micelle water. Before and after the formation of the micellar water, the decontamination capability of the babassu seed oil glyceryl polyether-8 esters is obviously changed, the performance of the surfactant can be fully exerted after the micellar water is formed, and the babassu seed oil glyceryl polyether-8 esters have good dissolving capability on common oil of color cosmetics.

The babassu seed oil glycerol polyether-8 esters of the present invention are available from Shanghai Yiheng chemical Co., Ltd.

Composite plant anti-allergic agent

Many people often have the phenomenon of skin allergy every season of climate change, great temperature difference or warm and humid seasons, which is called seasonal skin allergy in western medicine. Seasonal skin allergies are mainly due to a lag in the adaptation of humans to the environment. First, the skin's secreted lipids (sebum) together with the intercellular substance (especially ceramides) constitute the skin's chemical barrier, and when these substances are reduced, the skin barrier function will be diminished. In winter, sebum secretion is remarkably reduced and lipid components of the epidermis including ceramide are remarkably reduced as the temperature is lowered, which makes the skin barrier in a fragile state and weak against the outside. In the process of changing from winter to spring, seasons alternate, on one hand, the air temperature rises quickly, on the other hand, cold and hot air is frequently exchanged, the sunlight radiation intensity is increased, the humidity rises, bacteria are active frequently, and the skin cannot be adjusted in time, so that a series of uncomfortable symptoms occur.

The approaches taken against seasonal allergies are: 1) a layer of closed coat is added to the injured skin to block the stimulation of the external polluted environment to the skin and prevent the water in the skin from losing; 2) the skin is calmed, various allergic symptoms are relieved, and secondary invasion such as repeated scratching and scratching is prevented; 3) to solve the problem at all, it is still necessary to restore the fragile skin barrier to a healthy level making it a normally resistant skin. The main components of the composite plant anti-allergic agent are from natural plants, are mild and non-irritant, can inhibit inflammatory factors caused by various reasons (external stimulation or genetic factors), remarkably improve the immunological activity and the antioxidant activity of the skin, and have the effects of relieving and repairing the skin.

As a preferable technical scheme of the invention, the compound plant anti-allergy agent is a commercial product CalmYang.

CalmYang includes seven kinds of plant extract including centella asiatica, giant knotweed rhizome, skullcap root, green tea, glabrous licorice, chamomile, rosemary, etc. The product developed by screening more than 200 Chinese herbal medicines and specially used for treating dry skin, acute pruritus, inflammation, scars, exudate at affected parts and abnormal pigmentation can inhibit inflammatory factors caused by various reasons (external stimulation or genetic factors), remarkably improve the immunological activity and the antioxidant activity of the skin and has the effects of relieving and repairing the skin.

The composite plant anti-allergy agent CalmYang is purchased from Shanghai engineering Weekly chemical Co.

Hydrogenated castor oil

Hydrogenated castor oil is a modified castor oil product that is easily decomposed and does not have residues. The starting material is from hydrogenated castor oil which is a natural plant, can be biodegraded in nature, and is suitable for the industries of pesticides, coatings, daily chemicals, water-based ink, textile, printing and dyeing, papermaking, cosmetics and the like. Hydrogenated castor oil is an excellent nonionic solubilizer and emulsifier; has wide pH stability, low foam, and clear mixture with fatty acid and fatty alcohol at high temperature. Hydrogenated castor oil is a commonly used high-efficiency solubilizer, can be used in water or alcohol solution to solubilize oily substances such as essence, essential oil and synthetic perfume, and can be mixed with substances needing solubilization according to the ratio of 1: mixing and uniformly stirring the mixture according to the proportion of 1-3 until the mixture is transparent. Can be used as a pharmaceutical grade solubilizer. PEG-20 hydrogenated castor oil, PEG-40 hydrogenated castor oil and PEG-60 hydrogenated castor oil are three commonly used solubilizing agents, have similar properties and can be selected according to actual production.

The PEG-20 hydrogenated castor oil, the PEG-40 hydrogenated castor oil and the PEG-60 hydrogenated castor oil are purchased from Guangzhou Shiming chemical industry.

As a preferred technical solution of the present invention, the thickener is any one or more selected from carbomer, xanthan gum, natto gum, cellulose, sodium polyacrylate and polysorbate.

As a preferred technical scheme, the chelating agent is selected from one or more of disodium ethylene diamine tetraacetate, caprylyl hydroximic acid, sodium phytate and hydroxyphenylpropionamide benzoic acid.

In a preferred embodiment of the present invention, the pH adjuster is one or more selected from the group consisting of edetic acid, edetate disodium, citric acid, sodium citrate, sodium hydroxide, potassium hydroxide, and triethanolamine.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

In addition, the starting materials used are all commercially available, unless otherwise specified.

Example 1:

embodiment 1 provides a bacteriostatic wet tissue liquid, which at least comprises the following components in parts by weight: 15 parts of deionized water, 70 parts of cedar hydrolat, 0.001 part of cedar essential oil, 2 parts of humectant, 0.5 part of skin conditioner and 0.003 part of solubilizer. The humectant is glycerin. Glycerol, also known as glycerol, CAS: 56-81-5, wherein the glycerol used in the invention is Thailand lotus flower brand glycerol which is purchased from Shanghai vitamin grain chemical Co. The skin conditioner is a mixture of allantoin, babassu seed oil glyceryl polyether-8 esters and a composite plant anti-allergy agent, wherein the mass ratio of the allantoin to the babassu seed oil glyceryl polyether-8 esters to the composite plant anti-allergy agent is 1: 5: 3.6. the solubilizer is PEG-20 hydrogenated castor oil.

a. cleaning Bai 27097, removing impurities such as sand and soil on the surface, drying until the water content is less than 10%, pulverizing to below 30 mesh with a pulverizer, and filling into the middle part of a distillation tank;

c. after the air pressure is stable, the wood raw materials such as the roots and stems of the cypress 27097are fully contacted under the reduced pressure condition by spraying normal-temperature water at the top of the distillation retort to reduce the temperature, reduce the pressure and humidify, so that volatile components such as essential oil in the raw material tissues are extracted and mixed by steam under the condition of less pyrolysis and hydrolysis;

The preparation method of the bacteriostatic wet tissue liquid at least comprises the following steps:

Example 2:

embodiment 2 provides a bacteriostatic wet tissue liquid, which at least comprises the following components in parts by weight: 20 parts of deionized water, 80 parts of cedar hydrolat, 0.015 part of cedar essential oil, 7 parts of humectant, 3 parts of skin conditioner and 0.02 part of solubilizer. The humectant is methyl propylene glycol. Methyl propylene glycol, CAS: 2163-42-0, available from ALST CARE. The skin conditioner is a mixture of allantoin, babassu seed oil glyceryl polyether-8 esters and a composite plant anti-allergy agent, wherein the mass ratio of the allantoin to the babassu seed oil glyceryl polyether-8 esters to the composite plant anti-allergy agent is 3: 5: 5. the solubilizer is PEG-40 hydrogenated castor oil.

The preparation methods of cedar hydrolat and cedar essential oil are the same as example 1.

The preparation method of the bacteriostatic wet tissue liquid is the same as that of the embodiment 1.

Example 3:

embodiment 3 provides a bacteriostatic wet tissue liquid, which at least comprises the following components in parts by weight: 18.70 parts of deionized water, 75 parts of cypress hydrolat, 0.005 part of cypress essential oil, 4 parts of humectant, 1.2 parts of skin conditioner and 0.01 part of solubilizer. The humectant is dipropylene glycol. Dipropylene glycol, CAS: 246-770-3, purchased from OXEA, USA. The skin conditioner is a mixture of allantoin, babassu seed oil glyceryl polyether-8 esters and a composite plant anti-allergy agent, wherein the mass ratio of the allantoin to the babassu seed oil glyceryl polyether-8 esters to the composite plant anti-allergy agent is 2: 5: 5. the solubilizer is PEG-60 hydrogenated castor oil.

Example 4:

embodiment 4 provides a bacteriostatic wet tissue liquid, which at least comprises the following components in parts by weight: 17 parts of deionized water, 75 parts of cypress hydrolat, 0.01 part of cypress and shaddock peel essential oil, 5 parts of humectant, 1.2 parts of skin conditioner and 0.015 part of solubilizer. The humectant is methyl propylene glycol. Methyl propylene glycol, CAS: 2163-42-0, available from ALST CARE. The skin conditioner is a mixture of allantoin, babassu seed oil glyceryl polyether-8 esters and a composite plant anti-allergy agent, wherein the mass ratio of the allantoin to the babassu seed oil glyceryl polyether-8 esters to the composite plant anti-allergy agent is 2: 5: 5. the solubilizer is tween-80. The tween-80 was purchased from Guangzhou Suzuze environmental protection science and technology Limited.

The preparation method of the cedar and shaddock peel essential oil at least comprises the following steps:

drying the cedar wood and the shaddock peel until the water content is lower than 10%, respectively crushing the cedar wood and the shaddock peel to be below 100 meshes according to the weight ratio of 1: 0.2 weighing cedar wood powder and shaddock peel powder, adding 8 times of ethanol, soaking for 2.5h, extracting for 3 times by microwave heating, filtering, and recovering solvent to obtain cedar wood and shaddock peel essential oil.

Example 5:

embodiment 5 provides the bacteriostatic wet tissue liquid, which at least comprises the following components in parts by weight: 18.70 parts of deionized water, 75 parts of cypress hydrolat, 0.005 part of cypress and shaddock peel essential oil, 4 parts of humectant, 1.2 parts of skin conditioner and 0.01 part of solubilizer. The humectant is methyl propylene glycol. Methyl propylene glycol, CAS: 2163-42-0, available from ALST CARE. The skin conditioner is a mixture of allantoin, babassu seed oil glyceryl polyether-8 esters and a composite plant anti-allergy agent, wherein the mass ratio of the allantoin to the babassu seed oil glyceryl polyether-8 esters to the composite plant anti-allergy agent is 2: 5: 5. the solubilizer is PEG-40 hydrogenated castor oil.

The preparation method of cedar and shaddock peel essential oil is the same as that in example 4.

Example 6:

the specific implementation manner of example 6 is the same as that of example 5, except that the bacteriostatic agent further comprises an auxiliary agent, the mass fraction of the auxiliary agent in the bacteriostatic mask solution is 0.03%, and the auxiliary agent is triethanolamine as a pH regulator.

Triethanolamine, CAS: 102-71-6, available from makelin biochemical technologies, inc.

Comparative example 1:

the embodiment of comparative example 1 is the same as that of example 3 except that the cedar hydrolat is replaced with deionized water of equal mass.

Comparative example 2:

the embodiment of comparative example 2 is the same as that of example 3, except that the cedar essential oil is replaced by deionized water of the same quality.

Comparative example 3:

the embodiment of comparative example 3 is the same as that of example 6, except that the cedar and shaddock peel essential oils are replaced with deionized water of equal quality.

Comparative example 4:

the embodiment of comparative example 4 is the same as that of example 6, except that the cedar and grapefruit peel essential oils are replaced with equal quality grapefruit peel essential oils.

Comparative example 5:

comparative example 5 was carried out in the same manner as in example 6 except that cedar and grapefruit peel essential oils were changed to a mixture of cedar essential oil and grapefruit essential oil of equal quality.

Performance evaluation:

the bacteriostatic wet tissue liquid obtained in examples 1-6 and comparative examples 1-5 is used for producing bacteriostatic wet tissues. The bacteriostatic wet tissue comprises a flexible flaky fiber carrier, wherein the flexible flaky fiber carrier is immersed into the bacteriostatic wet tissue liquid, and the bacteriostatic wet tissue liquid is obtained by packaging after the flexible flaky fiber carrier is fully wetted. In the experimental process of the present invention, a spunlace nonwoven fabric was selected as the flexible sheet-like fibrous carrier.

1. Stability of

a. Placing the bacteriostatic wet tissue liquid in an electric heating constant temperature incubator at 45 +/-2 ℃ for 30 days, and observing the stability of the bacteriostatic wet tissue liquid after the temperature is recovered; b. placing the bacteriostatic wet tissue liquid in a refrigerator at (-5 +/-2) deg.C for 30 days, and observing the stability after recovering room temperature. And (3) observing items: the transparency, the precipitate, the odor change and the like of the bacteriostatic wet tissue liquid are recorded as stable if the bacteriostatic wet tissue liquid keeps transparent, has no precipitate and does not generate the odor change, otherwise, the record is not stable. The test results are shown in table 1.

2. Bacteriostatic activity

The bacteriostatic wet tissue prepared in the embodiments 1-6 and the comparative examples 1-5 is placed in a closed environment (25 ℃, the humidity is 60%), an open culture of escherichia coli and a culture of staphylococcus aureus are placed in the closed environment, the bacterial colony count (CFU/mL) of the bacteriostatic wet tissue is measured after the bacteriostatic wet tissue is placed for 8 hours, the bacteriostatic wet tissue is cut into pieces and then dispersed in 100mL of deionized water, the deionized water is soaked for 3 hours, the filtering is carried out, 1mL of a sample is cultured for 48 hours at 37 ℃, the total bacterial colony count is measured, and the test results are shown in Table 1.

TABLE 1

3. Skin testing

The age is 18-50 years, 600 sensitive skin testers (determined by an irritation test) are subjected to experiments and randomly divided into six groups, and no significant difference exists among the groups. The hand was cleaned with wet wipes prepared from the bacteriostatic wet wipe solutions of examples 1-6 once a day for a total of 28 days.

The experimental result shows that no skin allergy and irritation phenomenon occurs to the tested person in the 28-day testing process. According to the test result of the skin tester, the moisture content of the hand skin of more than 80% is increased, and the hand skin becomes healthier.

As can be seen from the table 1, the bacteriostatic wet tissue liquid disclosed by the invention is good in stability and bacteriostatic property, and has a maintenance effect without stimulation to skin.

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. The bacteriostatic wet tissue liquid is characterized by at least comprising the following components in parts by weight: 15-20 parts of deionized water, 70-80 parts of cypress hydrolat, 0.001-0.015 part of cypress and shaddock peel essential oil, 2-7 parts of humectant, 0.5-3 parts of skin conditioner and 0.003-0.02 part of solubilizer;

the humectant is micromolecular polyalcohol selected from any one or more of 1, 3-propylene glycol, glycerol, 1, 3-butanediol, methyl propylene glycol, 1, 2-pentanediol, 3-methyl-1, 3-butanediol, 1, 2-hexanediol, diglycerol, dipropylene glycol, sorbitol, 1, 2-octanediol, p-hydroxyacetophenone and D-panthenol;

the skin conditioner is a mixture of allantoin, babassu seed oil glyceryl polyether-8 esters and a composite plant anti-allergy agent, wherein the mass ratio of the allantoin to the babassu seed oil glyceryl polyether-8 esters to the composite plant anti-allergy agent is (1-3): 5: (3.6-5); the composite plant anti-allergy agent is a commercial product CalmYang;

the solubilizer is selected from any one or more of PEG-20 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil and Tween-80;

the preparation method of the cedar hydrolat at least comprises the following steps:

d.30min, closing an oil pump, naturally pressurizing to the same atmospheric pressure as the outside, opening a steam pipeline above a distillation retort, connecting a snakelike condenser, condensing steam, enabling the obtained liquid to enter a constant-temperature oil-water separator, decoloring by using activated carbon, separating an oil phase and an oil phase, and filtering to remove impurities to obtain a water phase which is cedar hydrolat;

2. The bacteriostatic wet tissue liquid according to claim 1, further comprising an auxiliary agent, wherein the mass fraction of the auxiliary agent in the bacteriostatic wet tissue liquid is less than 0.3%, and the auxiliary agent is selected from any one or more of a thickening agent, a chelating agent and a pH regulator.

3. A bacteriostatic wet tissue, which is characterized by comprising a flexible flaky fiber carrier, wherein the flexible flaky fiber carrier contains the bacteriostatic wet tissue liquid as defined in any one of claims 1-2.

4. The bacteriostatic wet wipe as set forth in claim 3, wherein the flexible sheet-like fibrous carrier is a spunlace nonwoven fabric, cotton fabric or paper towel.