CN114762702A - Sophora flavescens gel and preparation method and application thereof - Google Patents

Sophora flavescens gel and preparation method and application thereof Download PDF

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Publication number
CN114762702A
CN114762702A CN202110509713.0A CN202110509713A CN114762702A CN 114762702 A CN114762702 A CN 114762702A CN 202110509713 A CN202110509713 A CN 202110509713A CN 114762702 A CN114762702 A CN 114762702A
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parts
gel
sophora flavescens
humectant
active substance
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CN114762702B (en
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于秀华
韦安迪
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Shandong Huazhong Biotechnology Co ltd
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Shandong Huazhong Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention discloses a sophora flavescens gel and a preparation method thereof, wherein the sophora flavescens gel comprises the following raw materials in parts by weight: 8-12 parts of sophora flavescens active substance, 4.5-7 parts of antipruritic agent, 6-9 parts of aromatic, 18-23 parts of lubricant, 8-13 parts of active bacteria, 1-3 parts of amino acid, 6-8 parts of plant extract, 3-7 parts of vitamin, 2-4 parts of humectant, 1-3 parts of thickener, 1-2 parts of pH regulator and 100 parts of water supplement. The sophora flavescens gel is specifically compounded by a plurality of components, so that the anti-inflammation and comfort of the gel are improved; the combination of guar gum and luba gum increases the low-temperature stability of the gel, and avoids the phenomenon of flocculent precipitate of the gel in a low-temperature environment; the application of the gel and the castor oil can increase the coating property of the gel in use, reduce the generation of bubbles and improve the use feeling of consumers, and the gel is used for improving the female health problem.

Description

Sophora flavescens gel and preparation method and application thereof
Technical Field
The invention relates to the technical field of daily chemical articles for female hygiene and health, and in particular relates to sophora flavescens gel and a preparation method and application thereof.
Background
Gynecological inflammation is caused by invasion of pathogen bacteria due to external infection or injury, and comprises cervicitis, vaginitis, pelvic inflammation, cervical erosion and the like, which are common diseases that afflict a large number of female patients. The general treatment mode of gynecological inflammation mainly plays a role in killing pathogens through local administration, so that damaged tissues are repaired and a normal microenvironment state is presented, and the effect of healing is achieved.
Gels are thick liquid or semisolid preparations of the solution, suspension or emulsion type prepared from a drug and an excipient capable of forming a gel, which are limited to topical application to the skin and body cavities such as nasal, vaginal and rectal cavities. The gel in the market is various, but few products of the bacteriostatic gel for the private health of women have single efficacy and uneven effects, so that the company develops a gel taking radix sophorae flavescentis as an active component, has the efficacies of resisting bacteria, clearing damp, clearing heat, detoxifying, sterilizing and relieving itching, can quickly inhibit the proliferation of pathogenic bacteria and maintain and restore the local microecological balance. However, the applicant finds that the gel generates flocculent substances at low temperature during use, the low-temperature stability of the gel is poor, and in addition, the original gel generates a small amount of bubbles during coating, so that the use feeling of a consumer is influenced. In order to improve such a defect, the present application is specifically proposed.
Disclosure of Invention
In order to achieve the above object, a first aspect of the present invention provides a sophora flavescens gel, which comprises the following raw materials in parts by weight: 8-12 parts of sophora flavescens active substance, 4.5-7 parts of antipruritic agent, 6-9 parts of aromatic, 18-23 parts of lubricant, 8-13 parts of active bacteria, 1-3 parts of amino acid, 6-8 parts of plant extract, 3-7 parts of vitamin, 2-4 parts of humectant, 1-3 parts of thickener, 1-2 parts of pH regulator and 100 parts of water supplement.
As a preferred technical solution, the sophora flavescens active substance comprises sophora flavescens essential oil.
As a preferable technical scheme, the sophora flavescens active substance also comprises sophora flavescens root extract/octanoyl salicylic acid/potassium nonanoylglycinate active substance.
As a preferred technical scheme, the lubricant comprises at least two of xanthan gum, guar gum, locust bean gum and fenugreek gum.
As a preferred embodiment, the lubricant further comprises castor oil.
As a preferable technical scheme, the humectant comprises a small molecular alcohol and a polysaccharide humectant.
As a preferable technical scheme, the small molecular alcohol comprises one or more of butanediol, ethanol, propylene glycol, glycerol and sorbitol, and the polysaccharide humectant comprises chondroitin sulfate and glucosamine.
As a preferable technical scheme, the polysaccharide moisturizing agent further comprises sodium hyaluronate, wherein the sodium hyaluronate comprises a macromolecular sodium hyaluronate component and a small molecular sodium hyaluronate component, and the weight ratio is (2.3-4): 1.
the second aspect of the present invention provides a preparation method of sophora flavescens gel, comprising the following steps: weighing the raw materials according to a certain proportion, adding radix Sophorae Flavescentis active substance, antipruritic, aromatic, lubricant, active bacteria, amino acids, plant extract, vitamins, humectant, thickener and pH regulator into water, and mixing well to obtain the final product.
The third aspect of the invention provides an application of sophora flavescens gel in female sanitary health daily chemical products.
Has the advantages that:
(1) the sophora flavescens gel is compounded by a plurality of specific components, so that the anti-inflammation and comfort of the gel are improved;
(2) the combination of guar gum and luba gum increases the low-temperature stability of the gel, and avoids the phenomenon of flocculent precipitate of the gel in a low-temperature environment;
(3) the application of the gel in use can be improved by adopting the specific micromolecular alcohol and the castor oil, so that the generation of bubbles is reduced, and the use feeling of consumers is improved.
Detailed Description
The invention will be further understood by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definition provided in the present disclosure, the definition of the term provided in the present disclosure controls.
As used herein, a feature that does not define a singular or plural form is also intended to include a plural form of the feature unless the context clearly indicates otherwise. It will also be understood that the term "prepared from …," as used herein, is synonymous with "comprising," including, "comprising," "having," "containing," and/or "containing," when used in this specification denotes a stated composition, step, method, article, or apparatus, but does not preclude the presence or addition of one or more other compositions, steps, methods, articles, or apparatuses. Furthermore, the use of "preferred," "preferably," "more preferred," etc., when describing embodiments of the present invention, is meant to refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
In order to achieve the above object, a first aspect of the present invention provides a sophora flavescens gel, which comprises the following raw materials in parts by weight: 8-12 parts of sophora flavescens active substance, 4.5-7 parts of antipruritic agent, 6-9 parts of aromatic, 18-23 parts of lubricant, 8-13 parts of active bacteria, 1-3 parts of amino acid, 6-8 parts of plant extract, 3-7 parts of vitamin, 2-4 parts of humectant, 1-3 parts of thickener, 1-2 parts of pH regulator and 100 parts of water supplement.
More preferably, the feed comprises the following raw materials in parts by weight: 9 parts of sophora flavescens active substance, 5 parts of antipruritic agent, 7.2 parts of aromatic, 20 parts of lubricant, 10 parts of active bacteria, 1.5 parts of amino acid, 7.3 parts of plant extract, 5 parts of vitamin, 3 parts of humectant, 1.5 parts of thickening agent, 1.5 parts of pH regulator and 100 parts of water.
The active sophora flavescens substances mainly comprise alkaloid active substances, flavonoid active substances, fatty acid, volatile oil, amino acid and saccharides, particularly the alkaloid active substances have good antibacterial property, gel prepared by selecting the active sophora flavescens substances as main components has good antibacterial property, and the active sophora flavescens substances have different forms, such as existence of solid extracts, existence of liquid extracting solutions and existence of essential oil, and the active sophora flavescens substances in different forms have different possible active ingredients.
In some preferred embodiments, the sophora flavescens active substance comprises sophora flavescens essential oil.
The source of the sophora flavescens essential oil is not limited in the present invention, and can be purchased commercially, including but not limited to, from Ji' an Sheng Dai perfume oil Co.
In some preferred embodiments, the sophora flavescens active substance further comprises sophora flavescens active substance/caprylylsalicylic acid/azelaic acid potassium glycinate active substance.
More preferably, the kuh-seng root extract/caprylylsalicylic acid/potassium nonanoylglycinate active is available from beijing beili-lais biochemistry, inc, under the model of Brillian-neo QD 365.
In order to solve the problem that the vaginal pruritus is the symptom of gynecological inflammation, an antipruritic is added during preparation, because the product is used at sensitive parts, the antipruritic is a plant antipruritic, and the plant antipruritic can be exemplified by cardamom oil, folium artemisiae argyi extract, radix ophiopogonis extract, chamomile essential oil and the like.
In some preferred embodiments, the anti-itching agent is an artemisia argyi extract.
Through a large number of researches, the applicant finds that the folium artemisiae argyi extract is selected as the antipruritic, so that the antipruritic can achieve the aim of relieving itching, can increase the effects of clearing away heat and toxic materials and relieving itching of gel under the synergistic action of the aromatic and the active substances of the radix sophorae flavescentis in a system, and can quickly inhibit the proliferation of pathogenic bacteria.
The folium artemisiae argyi extract is not limited in source, and can be selected from saint biotechnology limited company of Ningshan country.
The generation of malodour in the pudendal environment is also a symptom of gynecological inflammation, and to reduce this malodour, certain fragrances are added to the system, which in some preferred embodiments include one or more of lemon essential oil, geranium essential oil, patchouli essential oil, ylang-ylang essential oil.
Preferably, the aromatic comprises lemon essential oil, geranium essential oil, patchouli essential oil and ylang-ylang essential oil, and the weight ratio is (1-3): (2.5-3.3): (8.6-9.5): (9-11).
More preferably, the aromatic comprises lemon essential oil, geranium essential oil, patchouli essential oil and ylang-ylang essential oil, and the weight ratio of the lemon essential oil to the geranium essential oil is 2: 3: 9: 10.
the source of the plant essential oil is not limited, and the plant essential oil can be purchased in the market, including but not limited to, the geranium essential oil is purchased from pure perfume oil of Hubei province Kangkang, the lemon essential oil is purchased from natural perfume oil plants of Jianmin, Jishui county, the patchouli essential oil is purchased from Xinda natural perfume plants, Jishui county, and the cananga essential oil is purchased from Shanghai Zixin Biotechnology, Inc.
In order to increase the comfort of the gel during use and to give the user a good lubricating experience, a certain amount of lubricant is added to the system.
In some preferred embodiments, the lubricant comprises at least two of xanthan gum, guar gum, locust bean gum, and fenugreek gum.
Applicants have found that the use of a combination of two or more of xanthan gum, guar gum, locust bean gum or fenugreek gum in the present system provides a very good increase in lubricity during use.
Preferably, the lubricant comprises a combination of guar gum and luba gum.
More preferably, the weight ratio of guar gum to lumba gum is 1: (12-15), more preferably 1: 13.8.
the guar and luba gums are commercially available, including but not limited to, guar gum from yatai chemical technologies, inc; the luba adhesive was purchased from Guangzhou Yutai chemical technology Co., Ltd.
The applicant previously prepared the gel taking radix sophorae flavescentis as an active component has a good antibacterial effect, but the gel is found to have poor low-temperature stability in the using process, and most gels on the market also have the defect of poor low-temperature stability The movement of active bacteria and the like causes the crystallization temperature to rise. In addition, the applicant has found through extensive studies that the weight ratio of guar gum to guava gum in the system of the present invention needs to be controlled between 1: (12-15), the reason is probably that the gel has poor coating property when the guar gum is too much dissolved in the system, and the gelatin has poor coating property when the guar gum is too much contained, and the reason is probably that the guar gum has certain compatibility, and when the amount of the guar gum is too much, the crystallization of amino acid, active bacteria and the like is promoted.
The active bacteria can eliminate oxygen free radicals, activate T cells, delay cell aging, decompose nitroso compounds and other organic carcinogens, inhibit bacteria, viruses and cancer cell growth by the principle of benefiting bacteria and inhibiting bacteria, reduce fat deposition on vessel walls, and regulate the blood fat level of a human body, thereby recovering natural self-healing force and enhancing and improving the immunologic function; in addition, the secretion of microorganisms in the 'active probiotics' such as active antibacterial small peptide, amino acid, oligomeric polysaccharide, organic acid, various vitamins, antiviral substances, antibiotic substances, various biochemical enzymes and the like can directly regulate the functions of various organs and increase nutrition, so that the microecological balance in the body is improved.
In some preferred embodiments, the active bacteria comprise at least one of lactobacillus/rice fermentation product, lactobacillus.
Preferably, the active bacteria comprise lactobacillus/rice fermentation product and lactobacillus, and the weight ratio of the lactobacillus to the rice fermentation product is (1-5): 10.
more preferably, the active bacteria comprise lactobacillus/rice fermentation product and lactobacillus, and the weight ratio of the lactobacillus to the rice fermentation product is 3: 10.
the invention of the lactobacillus/rice fermentation products and lactobacillus sources are not limited, can be purchased commercially available, including but not limited to, the lactobacillus/rice fermentation products from Wuhan Huazhi Kejie biotechnology Limited, the lactobacillus from Sai Anvet biotechnology Limited company.
In the invention, the addition of a proper amount of amino acid can inhibit pathogenic bacteria such as staphylococcus aureus, propionibacterium acnes and the like, inhibit the degradation of elastase and reduce the relaxation and aging rate of vagina; meanwhile, the pillow also has the effects of relieving pressure and soothing nerves.
In some preferred embodiments, the amino acid is water-soluble octanoylglycine.
The source of the water-soluble capryloyl glycine is not limited in the present invention and may be obtained commercially, including but not limited to, from beijing beijerine biochemistry inc.
The plant extract can play a certain opsonization, moisture retention and antibacterial property in the application, and the bacteriostatic efficacy of the gel is improved.
In some preferred embodiments, the plant extract comprises an arbutin extract and/or a perilla extract.
Preferably, the plant extract comprises arbutin extract and perilla extract, and the weight ratio of the arbutin extract to the perilla extract is (0.5-2): 1.
more preferably, the plant extract comprises arbutin extract and perilla extract, and the weight ratio of the arbutin extract to the perilla extract is 1.5: 1.
sources of arbutin extract and perilla extract are not limited in the present invention and may be commercially available, including but not limited to, arbutin extract from naerous sieboldii biotechnology limited and perilla extract from fangshonit biotechnology limited.
Vitamins are added to the present application for maintaining normal physiological function, and in some preferred embodiments, the vitamin is vitamin E.
The vitamin E is not limited in the present invention, and includes, but is not limited to, vitamin E available from Hippon Aicai Biotech Co.
The gel prepared by the original patent of the applicant can generate a small amount of bubbles when being coated, thereby influencing the use feeling of consumers, and the coating property of the gel currently used in the market is poor, the phenomena of air bubbles, excessive dispersion and the like are easily generated in the coating process, and the applicant finds that the application property of the gel in use can be improved by using glycerol, ethanol and castor oil through a great deal of research, probably because the ethanol can disperse polysaccharides and guar gum in the system, reduce the cohesive force of the system, increase the dispersibility of the system, meanwhile, the applicant finds out through a large number of experiments that the weight ratio of the glycerol to the ethanol is in a certain range, so that the gel can not be excessively dispersed and can be stably attached to the skin, on the one hand, the castor oil increases the dispersion of the aromatic in the system and simultaneously prevents the gel from generating bubbles and the like due to hand sticking during application.
In some preferred embodiments, the lubricant further comprises castor oil in an amount of 8 to 9 weight percent of the lubricant.
The castor oil may be purchased commercially, including, but not limited to, from Guangzhou Primary chemical Co., Ltd.
In some preferred embodiments, the humectant comprises a small molecule alcohol and a polysaccharide humectant.
In some preferred embodiments, the small molecule alcohol comprises one or more of butylene glycol, ethanol, propylene glycol, glycerin, and sorbitol, and the polysaccharide moisturizer comprises chondroitin sulfate and glucosamine.
Preferably, the small molecule alcohol comprises glycerol and ethanol, and the weight ratio of the glycerol to the ethanol is 1: (0.3-0.6), wherein the polysaccharide humectant comprises chondroitin sulfate and glucosamine, and the weight ratio of the chondroitin sulfate to the glucosamine is 1: (0.5-0.7).
More preferably, the small molecule alcohol comprises glycerol and ethanol, and the weight ratio of the glycerol to the ethanol is 1: 0.45, the polysaccharide humectant comprises chondroitin sulfate and glucosamine, and the weight ratio of the chondroitin sulfate to the glucosamine is 1: 0.6.
in some preferred embodiments, the polysaccharide moisturizer further comprises sodium hyaluronate which is 5 wt% of the polysaccharide moisturizer, the sodium hyaluronate comprising a macromolecular sodium hyaluronate component and a small molecular sodium hyaluronate component in a weight ratio of (2.3-4): 1.
preferably, the sodium hyaluronate comprises a macromolecular sodium hyaluronate component and a small molecular sodium hyaluronate component, and the weight ratio is 3.6: 1.
the sodium hyaluronate is commercially available, and includes, but is not limited to, the macromolecular sodium hyaluronate is obtained from Shandong Baolijia biological technology limited and has a molecular weight of 180-.
At present, most of gels on the market use sodium hyaluronate as a humectant, in order to increase the water locking and moisture retention of the gel, the applicant uses the synergistic effect of macromolecular sodium hyaluronate and micromolecular sodium hyaluronate, but finds that the anti-inflammation of the gel is slightly reduced, and the applicant finds that the anti-inflammation of the system can be increased by using a radix sophorae flavescentis extract/caprylyl salicylic acid/potassium azelaic acid active substance, chondroitin sulfate and glucosamine through a great deal of research, probably because the three components have certain antibacterial effects, and the synergistic effect of the potassium azelaic acid and the glucosamine and water-soluble caprylyl glycine can promote the absorption of the gel action part to the components such as radix sophorae flavescentis active substance, antipruritic agent, aromatic agent and the like in the gel, so that the effect of the anti-inflammation active component on the skin is improved, and the defect that the anti-inflammation effect is reduced by the micromolecular sodium hyaluronate is overcome, meanwhile, the glucosamine and glucose molecules in the arbutin extract core have synergistic effect, so that the gel also has good comfort.
In some preferred embodiments, the thickening agent comprises one or more of gum arabic, pectin, agar, gelatin, algin, carrageenan, dextrin, soluble starch, a polysaccharide derivative, carboxymethyl cellulose, propylene glycol alginate, methyl cellulose, sodium starch phosphate, sodium carboxymethyl cellulose.
Preferably, the thickener is carboxymethyl cellulose, and is mainly used for increasing the viscosity of the system so that the system can form uniform and stable gel.
In some preferred embodiments, the pH adjusting agent comprises one or more of citric acid, sodium citrate, disodium hydrogen phosphate.
Preferably, the pH adjusting agent is citric acid, which is used herein to maintain the stability of the system and promote the homogeneity of the gel formed.
In some preferred embodiments, the water comprises deionized or distilled water, preferably deionized water.
The second aspect of the present invention provides a preparation method of sophora flavescens gel, comprising the following steps: weighing the raw materials according to a certain proportion, adding radix Sophorae Flavescentis active substance, antipruritic, aromatic, lubricant, active bacteria, amino acids, plant extract, vitamins, humectant, thickener and pH regulator into water, and mixing well to obtain the final product.
The third aspect of the invention provides an application of sophora flavescens gel in female sanitary health daily chemical products.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
Example 1
The embodiment provides a sophora flavescens gel, which comprises the following raw materials in parts by weight: 9 parts of sophora flavescens active substance, 5 parts of antipruritic agent, 7.2 parts of aromatic, 20 parts of lubricant, 10 parts of active bacteria, 1.5 parts of amino acid, 7.3 parts of plant extract, 5 parts of vitamin, 3 parts of humectant, 1.5 parts of thickening agent, 1.5 parts of pH regulator and 100 parts of deionized water.
The active sophora flavescens substances comprise 6 parts of sophora flavescens essential oil, 3 parts of sophora flavescens root extract/caprylyl salicylic acid/potassium azeloylate glycinate active substances, the antipruritic agent is folium artemisiae argyi extract, the aromatic comprises a combination of lemon essential oil, geranium essential oil, patchouli essential oil and ylang-ylang essential oil, and the weight ratio is 2: 3: 9: 10, the lubricant comprises a combination of guar gum, luba gum, castor oil, wherein the weight ratio of guar gum to luba gum is 1: 13.8, the weight of the castor oil is 8.5 wt% of the lubricant, the active bacteria comprise lactobacillus/rice fermentation product and lactobacillus, and the weight ratio of the lactobacillus to the rice fermentation product is 3: 10, the amino acid is water-soluble caprylyl glycine, the plant extract comprises an arbutin extract and a perilla extract, and the weight ratio of the arbutin extract to the perilla extract is 1.5: 1, the vitamin is vitamin E, the humectant comprises a micromolecular alcohol and a polysaccharide humectant, and the weight ratio of the micromolecular alcohol to the polysaccharide humectant is 1: 1, wherein the small molecular alcohol comprises glycerol and ethanol, and the weight ratio of the glycerol to the ethanol is 1: 0.45, the polysaccharide humectant comprises chondroitin sulfate, glucosamine and sodium hyaluronate, wherein the sodium hyaluronate accounts for 5 wt% of the polysaccharide humectant, and the weight ratio of the chondroitin sulfate to the glucosamine is 1: 0.6, the sodium hyaluronate comprises macromolecular sodium hyaluronate and micromolecular sodium hyaluronate, and the weight ratio is 3.6: 1, the thickening agent is carboxymethyl cellulose, and the pH regulator is citric acid.
The sophora flavescens essential oil is purchased from Jian Shengda perfume oil Co., Ltd, the active substance of the sophora flavescens root extract/the octanoyl salicylic acid/the nonanedioyl potassium glycinate is purchased from Beijing Beili Lai Si biochemistry Co., Ltd, the model is Brillian-New QD365, the artemisia leaf extract is selected from the Ningshan Sheng Biotech Co., Ltd, the geranium essential oil is purchased from Hubei province Kangchu pure perfume Co., Ltd, the lemon essential oil is purchased from Jianmin natural perfume oil factory in Jishui county, the patchouli essential oil is purchased from Xinda natural perfume factory in Jishui county, the ylang essential oil is purchased from Shanghai Xin biotech Sci Co., Ltd, and the guar gum is purchased from Guangzhou Yutai chemical industry Co., Ltd; the luba gum is purchased from Guangzhou Yutai chemical technology, Inc., the castor oil is purchased from Guangzhou preliminary chemical, Inc., the lactobacillus/rice fermentation product is purchased from Wuhan Hua Zhi Kejie Biotechnology, Inc., the lactobacillus is purchased from Xianweite Biotech, Inc., the water-soluble caprylylglycine is purchased from Beijing Beili Lei Ling biochemicals, Inc., the arbutin extract is purchased from Xianyou Biotechnology, Inc., the perilla extract is purchased from Fufeng Snoote Biotechnology, Inc., the vitamin E is purchased from Shandong Aicai Biotechnology, Inc., the chondroitin sulfate is purchased from Shandong Hai Yu biotech, the CAS number of glucosamine is from 3416-24-8, the sodium hyaluronate is purchased from Shandong Baojia Biotechnology, Inc., the molecular weight is 180-200 ten thousand, and the small molecule sodium hyaluronate is purchased from Ward chemical engineering Co., Ltd in Hubei province and has the molecular weight of 20-40 ten thousand.
In another aspect, this embodiment provides a method for preparing sophora flavescens gel, which includes the following steps: weighing the raw materials according to a ratio, adding the sophora flavescens active substance, the antipruritic, the aromatic, the lubricant, the active bacteria, the amino acid, the plant extract, the vitamin, the humectant, the thickening agent and the pH regulator into deionized water, and uniformly mixing to obtain the traditional Chinese medicine.
Example 2
The embodiment provides a sophora flavescens gel which comprises the following raw materials in parts by weight: 8 parts of sophora flavescens active substance, 4.5 parts of antipruritic agent, 6 parts of aromatic, 18 parts of lubricant, 8 parts of active bacteria, 1 part of amino acid, 6 parts of plant extract, 3 parts of vitamin, 2 parts of humectant, 1 part of thickener, 1 part of pH regulator and 100 parts of deionized water.
The active sophora flavescens substances comprise 5.5 parts of sophora flavescens essential oil, 2.5 parts of sophora flavescens root extract/caprylyl salicylic acid/potassium azedaroyl glycinate active substances, the antipruritic agent is folium artemisiae argyi extract, the aromatic comprises the combination of lemon essential oil, geranium essential oil, patchouli essential oil and ylang-ylang essential oil, and the weight ratio is 2: 3: 9: 10, the lubricant comprises a combination of guar gum, luba gum, castor oil, wherein the weight ratio of guar gum to luba gum is 1: 12, the weight of the castor oil is 8 wt% of the lubricant, the active bacteria comprise lactobacillus/rice fermentation product and lactobacillus, and the weight ratio of the lactobacillus to the rice fermentation product is 3: 10, the amino acid is water-soluble caprylyl glycine, the plant extract comprises an arbutin extract and a perilla extract, and the weight ratio of the arbutin extract to the perilla extract is 1.5: 1, the vitamin is vitamin E, the humectant comprises a micromolecular alcohol and a polysaccharide humectant, and the weight ratio of the micromolecular alcohol to the polysaccharide humectant is 1: 1, the small molecular alcohol comprises glycerol and ethanol, and the weight ratio of the glycerol to the ethanol is 1: 0.3, the polysaccharide humectant comprises chondroitin sulfate, glucosamine and sodium hyaluronate, wherein the sodium hyaluronate accounts for 5 wt% of the polysaccharide humectant, and the weight ratio of the chondroitin sulfate to the glucosamine is 1: 0.5, the sodium hyaluronate comprises macromolecular sodium hyaluronate and micromolecular sodium hyaluronate components in a weight ratio of 2.3: 1, the thickening agent is carboxymethyl cellulose, and the pH regulator is citric acid.
The sophora flavescens essential oil is purchased from Jian Shengda perfume oil Co., Ltd, the active substance of the sophora flavescens root extract/the octanoyl salicylic acid/the nonanedioyl potassium glycinate is purchased from Beijing Beili Lai Si biochemistry Co., Ltd, the model is Brillian-New QD365, the artemisia leaf extract is selected from the Ningshan Sheng Biotech Co., Ltd, the geranium essential oil is purchased from Hubei province Kangchu pure perfume Co., Ltd, the lemon essential oil is purchased from Jianmin natural perfume oil factory in Jishui county, the patchouli essential oil is purchased from Xinda natural perfume factory in Jishui county, the ylang essential oil is purchased from Shanghai Xin biotech Sci Co., Ltd, and the guar gum is purchased from Guangzhou Yutai chemical industry Co., Ltd; the luba gum is purchased from Guangzhou Yutai chemical technology, Inc., the castor oil is purchased from Guangzhou preliminary chemical, Inc., the lactobacillus/rice fermentation product is purchased from Wuhan Hua Zhi Kejie Biotechnology, Inc., the lactobacillus is purchased from Xianweite Biotech, Inc., the water-soluble caprylylglycine is purchased from Beijing Beili Lei Ling biochemicals, Inc., the arbutin extract is purchased from Xianyou Biotechnology, Inc., the perilla extract is purchased from Fufeng Snoote Biotechnology, Inc., the vitamin E is purchased from Shandong Aicai Biotechnology, Inc., the chondroitin sulfate is purchased from Shandong Hai Yu biotech, the CAS number of glucosamine is from 3416-24-8, the sodium hyaluronate is purchased from Shandong Baojia Biotechnology, Inc., the molecular weight is 180-200 ten thousand, and the small molecule sodium hyaluronate is purchased from Ward chemical engineering Co., Ltd in Hubei province and has the molecular weight of 20-40 ten thousand.
In another aspect, this embodiment provides a method for preparing sophora flavescens gel, which includes the following steps: weighing the raw materials according to a ratio, adding radix Sophorae Flavescentis active substance, antipruritic, aromatic, lubricant, active bacteria, amino acids, plant extract, vitamins, humectant, thickener, and pH regulator into deionized water, and mixing well to obtain the final product.
Example 3
The embodiment provides a sophora flavescens gel which comprises the following raw materials in parts by weight: 12 parts of sophora flavescens active substance, 7 parts of antipruritic agent, 9 parts of aromatic, 23 parts of lubricant, 13 parts of active bacteria, 3 parts of amino acid, 8 parts of plant extract, 7 parts of vitamin, 4 parts of humectant, 3 parts of thickening agent, 2 parts of pH regulator and 100 parts of deionized water.
The active sophora flavescens substances comprise 8 parts of sophora flavescens essential oil, 4 parts of sophora flavescens root extract/caprylyl salicylic acid/potassium azeloylate glycinate active substances, the antipruritic agent is folium artemisiae argyi extract, the aromatic comprises a combination of lemon essential oil, geranium essential oil, patchouli essential oil and ylang-ylang essential oil, and the weight ratio is 2: 3: 9: 10, the lubricant comprises a combination of guar gum, luba gum, castor oil, wherein the weight ratio of guar gum to luba gum is 1: 15, the weight of the castor oil is 9 wt% of the lubricant, the active bacteria comprise lactobacillus/rice fermentation product and lactobacillus, and the weight ratio of the lactobacillus to the rice fermentation product is 3: 10, the amino acid is water-soluble caprylyl glycine, the plant extract comprises an arbutin extract and a perilla extract, and the weight ratio of the arbutin extract to the perilla extract is 1.5: 1, the vitamin is vitamin E, the humectant comprises a micromolecular alcohol and a polysaccharide humectant, and the weight ratio of the micromolecular alcohol to the polysaccharide humectant is 1: 1, the small molecular alcohol comprises glycerol and ethanol, and the weight ratio of the glycerol to the ethanol is 1: 0.6, the polysaccharide humectant comprises chondroitin sulfate, glucosamine and sodium hyaluronate, wherein the sodium hyaluronate accounts for 5 wt% of the polysaccharide humectant, and the weight ratio of the chondroitin sulfate to the glucosamine is 1: 0.7, the sodium hyaluronate comprises components of macromolecular sodium hyaluronate and micromolecular sodium hyaluronate, and the weight ratio is 4: 1, the thickening agent is carboxymethyl cellulose, and the pH regulator is citric acid.
The sophora flavescens essential oil is purchased from Jian Shengda perfume oil Co., Ltd, the active substance of the sophora flavescens root extract/the octanoyl salicylic acid/the nonanedioyl potassium glycinate is purchased from Beijing Beili Lai Si biochemistry Co., Ltd, the model is Brillian-New QD365, the artemisia leaf extract is selected from the Ningshan Sheng Biotech Co., Ltd, the geranium essential oil is purchased from Hubei province Kangchu pure perfume Co., Ltd, the lemon essential oil is purchased from Jianmin natural perfume oil factory in Jishui county, the patchouli essential oil is purchased from Xinda natural perfume factory in Jishui county, the ylang essential oil is purchased from Shanghai Xin biotech Sci Co., Ltd, and the guar gum is purchased from Guangzhou Yutai chemical industry Co., Ltd; the luba gum is purchased from Guangzhou Yutai chemical technology, Inc., the castor oil is purchased from Guangzhou preliminary chemical, Inc., the lactobacillus/rice fermentation product is purchased from Wuhan Hua Zhi Kejie Biotechnology, Inc., the lactobacillus is purchased from Xianweite Biotech, Inc., the water-soluble caprylylglycine is purchased from Beijing Beili Lei Ling biochemicals, Inc., the arbutin extract is purchased from Xianyou Biotechnology, Inc., the perilla extract is purchased from Fufeng Snoote Biotechnology, Inc., the vitamin E is purchased from Shandong Aicai Biotechnology, Inc., the chondroitin sulfate is purchased from Shandong Hai Yu biotech, the CAS number of glucosamine is from 3416-24-8, the sodium hyaluronate is purchased from Shandong Baojia Biotechnology, Inc., the molecular weight is 180-200 ten thousand, and the small-molecule sodium hyaluronate is purchased from Hubei Kyowa Kyoidechemical engineering Co., Ltd, and the molecular weight is 20-40 ten thousand.
In another aspect, this embodiment provides a method for preparing sophora flavescens gel, which includes the following steps: weighing the raw materials according to a ratio, adding the sophora flavescens active substance, the antipruritic, the aromatic, the lubricant, the active bacteria, the amino acid, the plant extract, the vitamin, the humectant, the thickening agent and the pH regulator into deionized water, and uniformly mixing to obtain the traditional Chinese medicine.
Example 4
The embodiment of the present invention provides a sophora flavescens gel and a preparation method thereof, which is the same as example 1 except that no guar gum is contained.
Example 5
The embodiment of the present invention provides a sophora flavescens gel and a preparation method thereof, and the specific implementation manner of the sophora flavescens gel is the same as that of example 1, except that the weight ratio of the guar gum to the lumba gum is 1: 8.
example 6
The embodiment of the present invention provides a sophora flavescens gel and a preparation method thereof, and the specific implementation manner of the sophora flavescens gel is the same as that of example 1, except that the weight ratio of the guar gum to the lumba gum is 1: 20.
example 7
The embodiment of the present invention provides a sophora flavescens gel and a preparation method thereof, which is the same as example 1 except that the small molecular alcohol does not include ethanol.
Example 8
The embodiment of the present invention provides a sophora flavescens gel and a preparation method thereof, and the specific implementation manner of the sophora flavescens gel is the same as that of embodiment 1, wherein the weight ratio of glycerol to ethanol is 1: 0.2.
example 9
The embodiment of the present invention provides a sophora flavescens gel and a preparation method thereof, and the specific implementation manner of the sophora flavescens gel is the same as that of embodiment 1, wherein the weight ratio of glycerol to ethanol is 1: 0.7.
example 10
This example provides a kuh-seng gel and a method for preparing the same, and the specific embodiment is the same as example 1, except that the lubricant does not contain castor oil.
Performance testing
1. Low temperature stability test
20g of each of the gels prepared in examples 1 to 10 was placed in an incubator at 0 ℃ for 24 hours, and then the state of the gel was observed.
2. Coatability test
3g of each of the gels prepared in examples 1 to 10 was uniformly applied to an arm with a coating area of 4 cm. times.4 cm, and the phenomenon during the coating process was observed.
The test results are shown in Table 1.
TABLE 1
Figure BDA0003059859900000131
Finally, it should be understood that the above-described embodiments are merely preferred embodiments of the present invention, and not intended to limit the present invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (10)

1. The sophora flavescens gel is characterized by comprising the following raw materials in parts by weight: 8-12 parts of sophora flavescens active substance, 4.5-7 parts of antipruritic agent, 6-9 parts of aromatic, 18-23 parts of lubricant, 8-13 parts of active bacteria, 1-3 parts of amino acid, 6-8 parts of plant extract, 3-7 parts of vitamin, 2-4 parts of humectant, 1-3 parts of thickener, 1-2 parts of pH regulator and 100 parts of water supplement.
2. The sophora flavescens gel as claimed in claim 1, wherein the sophora flavescens active substance comprises sophora flavescens essential oil.
3. The sophora flavescens gel of claim 2, wherein the sophora flavescens active substance further comprises sophora flavescens active substance/octanoyl salicylic acid/potassium nonanedioyl glycinate active substance.
4. The sophora flavescens gel of claim 1 or 2, wherein the lubricant comprises at least two of xanthan gum, guar gum, locust bean gum, and fenugreek gum.
5. The sophora flavescens gel of claim 4, wherein the lubricant further comprises castor oil.
6. The sophora flavescens gel as claimed in claim 1 or 2, wherein the humectant comprises a small molecular alcohol and a polysaccharide humectant.
7. The sophora flavescens gel as claimed in claim 6, wherein the small-molecule alcohol comprises one or more of butylene glycol, ethanol, propylene glycol, glycerol and sorbitol, and the polysaccharide humectant comprises chondroitin sulfate and glucosamine.
8. The sophora flavescens gel as claimed in claim 7, wherein the polysaccharide humectant further comprises sodium hyaluronate, the sodium hyaluronate comprises a large molecule sodium hyaluronate and a small molecule sodium hyaluronate, and the weight ratio of the components is (2.3-4): 1.
9. the preparation method of the sophora flavescens gel according to any one of claims 1 to 8, comprising the following steps: weighing the raw materials according to a certain proportion, adding radix Sophorae Flavescentis active substance, antipruritic, aromatic, lubricant, active bacteria, amino acids, plant extract, vitamins, humectant, thickener and pH regulator into water, and mixing well to obtain the final product.
10. Use of the sophora flavescens gel as claimed in any one of claims 1 to 8 for improving the health problem of female hygiene.
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CN111743986A (en) * 2020-07-08 2020-10-09 山东川云生物科技有限公司 Gynecological gel and preparation method thereof
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