CN110124017A - A kind of bacteriostatic gel - Google Patents
A kind of bacteriostatic gel Download PDFInfo
- Publication number
- CN110124017A CN110124017A CN201910422506.4A CN201910422506A CN110124017A CN 110124017 A CN110124017 A CN 110124017A CN 201910422506 A CN201910422506 A CN 201910422506A CN 110124017 A CN110124017 A CN 110124017A
- Authority
- CN
- China
- Prior art keywords
- medicinal material
- parts
- mixed
- bacteriostatic gel
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of bacteriostatic gel, raw material includes water, glycerol, ethyl alcohol, hydroxyethyl cellulose, sodium acetate, isopropanol, PPG-26- butylol polyether -26, Cremophor RH40, lactic acid, triethanolamine, inulin, alpha-glucans oligosaccharides, sodium citrate, Euglena gracilis polysaccharide, hydrolytic collagen and pumpkin fermenting product extract.The present invention tightens uterus, facilitates love life harmony, keeps women more self-confident; good antimicrobial effect; curative effect long action time can cure the symptoms such as some eczemas, itch, can the skin to patient protected for a long time; it is poor to solve existing bacteriostatic gel fungistatic effect; curative effect action time is short, can not cure to symptoms such as some eczemas, itch, can not the skin to patient protected for a long time; the applicability for reducing bacteriostatic gel is not easy to the problem of people use.
Description
Technical field
The present invention relates to Gynecological health nursing technique field, specially a kind of bacteriostatic gel.
Background technique
Colloidal particle or macromolecule in colloidal sol or solution interconnect under certain condition, form space net structure,
It is filled in structural void and (is also possible to gas in xerogel, xerogel is also referred to as airsetting as the liquid of decentralized medium
Glue), such a special dispersion is referred to as gel, and bacteriostatic gel is a public type product for biasing toward anti-inflammatory, most suitable
Close the age below 30 one full year of life, sexual life excessively frequently, because operating pressure generates slight premenstrual syndrome, gynecological disease compares
More young woman, the chronic inflammations such as target user's original acquired dysmenorrhea, vaginitis, vulvitis, chronic pelvic inflammatory disease, chronic cervicitis
Disease, fibroid, uterus adenomyosis, ovarian cyst etc..
Gynecological gel is a kind of gynaecology's drug, and gelling agent, common gel is mainly used for various gynaecology's yin currently on the market
Road is scorching, cervicitis treatment, comprising: bacterial vaginitis, trichomonas vaginitis, Combination vaginitis, gonococcal infection, chronic
Cervicitis, have anti-inflammatory, sterilization, itching-relieving action, to staphylococcus aureus, Escherichia coli, gonococcus, candida albicans,
The growth of the pathogen microorganism such as fungi, saccharomycete has obvious inhibiting effect, also has gel products for lubricating vaginal wall, releases
It has sexual intercourse painful, existing bacteriostatic gel does not have the effect in tightening uterus, and for women after the complete child of life, metreurysma can not
Restore completely, to bringing inconvenience on female pathology.
Summary of the invention
The purpose of the present invention is to provide a kind of bacteriostatic gels, have tightening uterus, good antimicrobial effect, curative effect action time
It is long, the advantages of capable of curing, can be protected for a long time to the skin of patient to symptoms such as some eczemas, itch, solve
Existing bacteriostatic gel does not have the effect in tightening uterus, and women is after the complete child of life, metreurysma, can not be completely extensive
Again, to making troubles on female pathology the problem of.
To achieve the above object, the invention provides the following technical scheme: a kind of bacteriostatic gel, raw material include water, glycerol,
Ethyl alcohol, hydroxyethyl cellulose, sodium acetate, isopropanol, PPG-26- butylol polyether -26, Cremophor RH40, lactic acid, three second
Hydramine, inulin, alpha-glucans oligosaccharides, sodium citrate, Euglena gracilis polysaccharide, hydrolytic collagen and pumpkin fermenting product extract, institute
It states each component and is respectively as follows: water 80-150, glycerol 40-45, ethyl alcohol 10-20, hydroxyethyl cellulose 30-40, sodium acetate by weight
50-60, -26 10-20 of isopropanol 35-45, PPG-26- butylol polyether, Cremophor RH40 30-40, lactic acid 20-30, three
Ethanol amine 35-45, inulin 50-60, alpha-glucans oligosaccharides 25-35, sodium citrate 15-25, Euglena gracilis polysaccharide 10-20, hydrolysis
Collagen 30-40 and pumpkin fermenting product extract 20-35.
Preferably, the bacteriostatic gel further includes chlorhexidine acetate, menthol, Sodium Hyaluronate cross-linked polymer, 1,2-
Pentanediol, rose oil and Fructus Citri grandis extract, each component are respectively as follows: chlorhexidine acetate 25-35, menthol by weight
10-20, Sodium Hyaluronate cross-linked polymer 10-20,1,2- pentanediol 20-30, rose oil 30-40 and Fructus Citri grandis extract 40-
50。
Preferably, the preparation process the following steps are included:
Step 1: taking medicinal material to clean, and the medicinal material of selection is placed on the pallet of balance and is weighed, and chooses most according to composition by weight
Big component；
Step 2: it takes smashed medicine raw material to be put into medicinal material pulverizer and carries out crushing and processing, smashed medicinal material is put into
It is ground in medicinal material grinder, sieve is taken to be filtered the medicinal material after grinding, the medicinal material for not passing through sieve, which is placed again into, to be ground
It is ground in grinding machine, until completely extending across sieve；
Step 3: taking smashed medicinal material to be put into medicinal material blender, and water is added and is mixed, and observation mixture is viscous
Consistency；
Step 4: after object to be mixed is thoroughly mixed, glycerol, Cremophor RH40 mixing is added into mixture respectively
Stirring, stirring are added ethyl alcohol into mixture after ten minutes, again and are stirred to obtain mixed liquor A；
Step 5: it is few that isopropanol, PPG-26- butylol polyether -26, lactic acid, alpha-glucans are separately added into mixed liquor A
Sugar, triethanolamine and sodium citrate are mixed to obtain mixed liquid B.
Step 6: hydrolytic collagen, pumpkin fermenting product extract, chlorhexidine acetate, peppermint are separately added into mixed liquid B
Alcohol, Sodium Hyaluronate cross-linked polymer, 1,2- pentanediol and Fructus Citri grandis extract are mixed, and paste is stirred into, and suppression is made
Bacterium gel.
Preferably, the medicinal material that weighing is chosen in step 1 be respectively hydroxyethyl cellulose, it is sodium acetate, inulin, thin
Small Euglena polysaccharide and menthol, choose medicinal material peace parts by weight be respectively hydroxyethyl cellulose 40, it is sodium acetate 60, inulin 60, tiny
Euglena polysaccharide 20 and menthol 20.
Preferably, it is 2 to 3 times that the material in step 2, which crushes number, take the sieve of 60 mesh to the medicinal material after grinding into
Row filtering.
Preferably, 80 purified water of component that is added in step 3 is mixed, and observation mixture viscosity can
Water is added again and adjusts its mixture viscosity.
Preferably, described to observe mixture viscosity with eyes in step 5, it can be sticky by adding water to adjust mixture
Degree.
Compared with prior art, beneficial effects of the present invention are as follows:
The present invention tightens uterus, facilitates love life harmony, keeps women more self-confident, good antimicrobial effect, curative effect effect
Time is long, can cure to symptoms such as some eczemas, itch, can the skin to patient protected for a long time, solve
Existing bacteriostatic gel fungistatic effect is poor, and curative effect action time is short, can not cure to symptoms such as some eczemas, itch,
Can not the skin to patient protected for a long time, reduce the applicability of bacteriostatic gel, be not easy to people use the problem of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
A kind of bacteriostatic gel, raw material include water, glycerol, ethyl alcohol, hydroxyethyl cellulose, sodium acetate, isopropanol, PPG-
It is 26- butylol polyether -26, Cremophor RH40, lactic acid, triethanolamine, inulin, alpha-glucans oligosaccharides, sodium citrate, tiny
Euglena polysaccharide, hydrolytic collagen, pumpkin fermenting product extract, chlorhexidine acetate, menthol, Sodium Hyaluronate cross-linked polymer,
1,2- pentanediol, rose oil and Fructus Citri grandis extract, each component be respectively as follows: by weight water 80-150, glycerol 40-45,
Ethyl alcohol 10-20, hydroxyethyl cellulose 30-40, sodium acetate 50-60, isopropanol 35-45, PPG-26- butylol polyether -2610-20,
Cremophor RH40 30-40, lactic acid 20-30, triethanolamine 35-45, inulin 50-60, alpha-glucans oligosaccharides 25-35, lemon
Lemon acid sodium 15-25, Euglena gracilis polysaccharide 10-20, hydrolytic collagen and pumpkin fermenting product extract 20-35, chlorhexidine acetate 25-
35, menthol 10-20, Sodium Hyaluronate cross-linked polymer 10-20,1,2- pentanediol 20-30, rose oil 30-40 and shaddock fruit
Extract 40-50.
Embodiment one
The composition proportion of use are as follows: 80 parts of water, 40 parts of glycerol, 10 parts of ethyl alcohol, 30 parts of hydroxyethyl cellulose, sodium acetate 50
Part, 35 parts of isopropanol, -26 10 parts of PPG-26- butylol polyether, 30 parts of Cremophor RH40,20 parts of lactic acid, triethanolamine
35 parts, 50 parts of inulin, 25 parts of alpha-glucans oligosaccharides, 15 parts of sodium citrate, 10 parts of Euglena gracilis polysaccharide, 30 parts of hydrolytic collagen, south
20 parts of melon tunning extract, 25 parts of chlorhexidine acetate, 10 parts of menthol, 10 parts of Sodium Hyaluronate cross-linked polymer, 1,2-
20 parts of pentanediol, 30 parts of rose oil and 40 parts of Fructus Citri grandis extract.
The preparation process of the present embodiment the following steps are included:
Step 1: taking medicinal material to clean, and the medicinal material of selection is placed on the pallet of balance and is weighed, and chooses most according to composition by weight
Big component；
Step 2: it takes smashed medicine raw material to be put into medicinal material pulverizer and carries out crushing and processing, smashed medicinal material is put into
It is ground in medicinal material grinder, sieve is taken to be filtered the medicinal material after grinding, the medicinal material for not passing through sieve, which is placed again into, to be ground
It is ground in grinding machine, until completely extending across sieve；
Step 3: taking smashed medicinal material to be put into medicinal material blender, and water is added and is mixed, and observation mixture is viscous
Consistency；
Step 4: after object to be mixed is thoroughly mixed, glycerol, Cremophor RH40 mixing is added into mixture respectively
Stirring, stirring are added ethyl alcohol into mixture after ten minutes, again and are stirred to obtain mixed liquor A；
Step 5: it is few that isopropanol, PPG-26- butylol polyether -26, lactic acid, alpha-glucans are separately added into mixed liquor A
Sugar, triethanolamine and sodium citrate are mixed to obtain mixed liquid B.
Step 6: hydrolytic collagen, pumpkin fermenting product extract, chlorhexidine acetate, peppermint are separately added into mixed liquid B
Alcohol, Sodium Hyaluronate cross-linked polymer, 1,2- pentanediol and Fructus Citri grandis extract are mixed, and paste is stirred into, and suppression is made
Bacterium gel.
In the present embodiment, the medicinal material that weighing is chosen in step 1 is respectively hydroxyethyl cellulose, sodium acetate, inulin, thin
Small Euglena polysaccharide and menthol, choose medicinal material peace parts by weight be respectively hydroxyethyl cellulose 40, it is sodium acetate 60, inulin 60, tiny
Euglena polysaccharide 20 and menthol 20, it is 2 to 3 times that material, which crushes number, in step 2, takes the sieve of 60 mesh to the medicinal material after grinding
It is filtered, 80 purified water of component is added in step 3 and is mixed, water can be added in observation mixture viscosity again
Its mixture viscosity is adjusted, observes mixture viscosity with eyes in step 5, it can be sticky by adding water to adjust mixture
Degree.
Embodiment two
The composition proportion of use are as follows: 82 parts of water, 42 parts of glycerol, 12 parts of ethyl alcohol, 32 parts of hydroxyethyl cellulose, sodium acetate 52
Part, 37 parts of isopropanol, -26 12 parts of PPG-26- butylol polyether, 32 parts of Cremophor RH40,22 parts of lactic acid, triethanolamine
37 parts, 52 parts of inulin, 27 parts of alpha-glucans oligosaccharides, 17 parts of sodium citrate, 12 parts of Euglena gracilis polysaccharide, 32 parts of hydrolytic collagen, south
22 parts of melon tunning extract, 27 parts of chlorhexidine acetate, 12 parts of menthol, 12 parts of Sodium Hyaluronate cross-linked polymer, 1,2-
22 parts of pentanediol, 32 parts of rose oil and 42 parts of Fructus Citri grandis extract.
The preparation process of the present embodiment the following steps are included:
Step 1: taking medicinal material to clean, and the medicinal material of selection is placed on the pallet of balance and is weighed, and chooses most according to composition by weight
Big component；
Step 2: it takes smashed medicine raw material to be put into medicinal material pulverizer and carries out crushing and processing, smashed medicinal material is put into
It is ground in medicinal material grinder, sieve is taken to be filtered the medicinal material after grinding, the medicinal material for not passing through sieve, which is placed again into, to be ground
It is ground in grinding machine, until completely extending across sieve；
Step 3: taking smashed medicinal material to be put into medicinal material blender, and water is added and is mixed, and observation mixture is viscous
Consistency；
Step 4: after object to be mixed is thoroughly mixed, glycerol, Cremophor RH40 mixing is added into mixture respectively
Stirring, stirring are added ethyl alcohol into mixture after ten minutes, again and are stirred to obtain mixed liquor A；
Step 5: it is few that isopropanol, PPG-26- butylol polyether -26, lactic acid, alpha-glucans are separately added into mixed liquor A
Sugar, triethanolamine and sodium citrate are mixed to obtain mixed liquid B.
Step 6: hydrolytic collagen, pumpkin fermenting product extract, chlorhexidine acetate, peppermint are separately added into mixed liquid B
Alcohol, Sodium Hyaluronate cross-linked polymer, 1,2- pentanediol and Fructus Citri grandis extract are mixed, and paste is stirred into, and suppression is made
Bacterium gel.
In the present embodiment, the medicinal material that weighing is chosen in step 1 is respectively hydroxyethyl cellulose, sodium acetate, inulin, thin
Small Euglena polysaccharide and menthol, choose medicinal material peace parts by weight be respectively hydroxyethyl cellulose 40, it is sodium acetate 60, inulin 60, tiny
Euglena polysaccharide 20 and menthol 20, it is 2 to 3 times that material, which crushes number, in step 2, takes the sieve of 60 mesh to the medicinal material after grinding
It is filtered, 80 purified water of component is added in step 3 and is mixed, water can be added in observation mixture viscosity again
Its mixture viscosity is adjusted, observes mixture viscosity with eyes in step 5, it can be sticky by adding water to adjust mixture
Degree.
Embodiment three
The composition proportion of use are as follows: 85 parts of water, 44 parts of glycerol, 14 parts of ethyl alcohol, 34 parts of hydroxyethyl cellulose, sodium acetate 54
Part, 39 parts of isopropanol, -26 14 parts of PPG-26- butylol polyether, 34 parts of Cremophor RH40,24 parts of lactic acid, triethanolamine
39 parts, 54 parts of inulin, 29 parts of alpha-glucans oligosaccharides, 19 parts of sodium citrate, 14 parts of Euglena gracilis polysaccharide, 34 parts of hydrolytic collagen, south
24 parts of melon tunning extract, 29 parts of chlorhexidine acetate, 14 parts of menthol, 14 parts of Sodium Hyaluronate cross-linked polymer, 1,2-
24 parts of pentanediol, 34 parts of rose oil and 44 parts of Fructus Citri grandis extract.
The preparation process of the present embodiment the following steps are included:
Step 1: taking medicinal material to clean, and the medicinal material of selection is placed on the pallet of balance and is weighed, and chooses most according to composition by weight
Big component；
Step 2: it takes smashed medicine raw material to be put into medicinal material pulverizer and carries out crushing and processing, smashed medicinal material is put into
It is ground in medicinal material grinder, sieve is taken to be filtered the medicinal material after grinding, the medicinal material for not passing through sieve, which is placed again into, to be ground
It is ground in grinding machine, until completely extending across sieve；
Step 3: taking smashed medicinal material to be put into medicinal material blender, and water is added and is mixed, and observation mixture is viscous
Consistency；
Step 4: after object to be mixed is thoroughly mixed, glycerol, Cremophor RH40 mixing is added into mixture respectively
Stirring, stirring are added ethyl alcohol into mixture after ten minutes, again and are stirred to obtain mixed liquor A；
Step 5: it is few that isopropanol, PPG-26- butylol polyether -26, lactic acid, alpha-glucans are separately added into mixed liquor A
Sugar, triethanolamine and sodium citrate are mixed to obtain mixed liquid B.
Step 6: hydrolytic collagen, pumpkin fermenting product extract, chlorhexidine acetate, peppermint are separately added into mixed liquid B
Alcohol, Sodium Hyaluronate cross-linked polymer, 1,2- pentanediol and Fructus Citri grandis extract are mixed, and paste is stirred into, and suppression is made
Bacterium gel.
In the present embodiment, the medicinal material that weighing is chosen in step 1 is respectively hydroxyethyl cellulose, sodium acetate, inulin, thin
Small Euglena polysaccharide and menthol, choose medicinal material peace parts by weight be respectively hydroxyethyl cellulose 40, it is sodium acetate 60, inulin 60, tiny
Euglena polysaccharide 20 and menthol 20, it is 2 to 3 times that material, which crushes number, in step 2, takes the sieve of 60 mesh to the medicinal material after grinding
It is filtered, 80 purified water of component is added in step 3 and is mixed, water can be added in observation mixture viscosity again
Its mixture viscosity is adjusted, observes mixture viscosity with eyes in step 5, it can be sticky by adding water to adjust mixture
Degree.
Example IV
The composition proportion of use are as follows: 100 parts of water, 45 parts of glycerol, 15 parts of ethyl alcohol, 35 parts of hydroxyethyl cellulose, sodium acetate 55
Part, 40 parts of isopropanol, -26 15 parts of PPG-26- butylol polyether, 35 parts of Cremophor RH40,25 parts of lactic acid, triethanolamine
40 parts, 55 parts of inulin, 30 parts of alpha-glucans oligosaccharides, 20 parts of sodium citrate, 15 parts of Euglena gracilis polysaccharide, 35 parts of hydrolytic collagen, south
25 parts of melon tunning extract, 30 parts of chlorhexidine acetate, 15 parts of menthol, 15 parts of Sodium Hyaluronate cross-linked polymer, 1,2-
25 parts of pentanediol, 35 parts of rose oil and 45 parts of Fructus Citri grandis extract.
The preparation process of the present embodiment the following steps are included:
Step 1: taking medicinal material to clean, and the medicinal material of selection is placed on the pallet of balance and is weighed, and chooses most according to composition by weight
Big component；
Step 2: it takes smashed medicine raw material to be put into medicinal material pulverizer and carries out crushing and processing, smashed medicinal material is put into
It is ground in medicinal material grinder, sieve is taken to be filtered the medicinal material after grinding, the medicinal material for not passing through sieve, which is placed again into, to be ground
It is ground in grinding machine, until completely extending across sieve；
Step 3: taking smashed medicinal material to be put into medicinal material blender, and water is added and is mixed, and observation mixture is viscous
Consistency；
Step 4: after object to be mixed is thoroughly mixed, glycerol, Cremophor RH40 mixing is added into mixture respectively
Stirring, stirring are added ethyl alcohol into mixture after ten minutes, again and are stirred to obtain mixed liquor A；
Step 5: it is few that isopropanol, PPG-26- butylol polyether -26, lactic acid, alpha-glucans are separately added into mixed liquor A
Sugar, triethanolamine and sodium citrate are mixed to obtain mixed liquid B.
Step 6: hydrolytic collagen, pumpkin fermenting product extract, chlorhexidine acetate, peppermint are separately added into mixed liquid B
Alcohol, Sodium Hyaluronate cross-linked polymer, 1,2- pentanediol and Fructus Citri grandis extract are mixed, and paste is stirred into, and suppression is made
Bacterium gel.
In the present embodiment, the medicinal material that weighing is chosen in step 1 is respectively hydroxyethyl cellulose, sodium acetate, inulin, thin
Small Euglena polysaccharide and menthol, choose medicinal material peace parts by weight be respectively hydroxyethyl cellulose 40, it is sodium acetate 60, inulin 60, tiny
Euglena polysaccharide 20 and menthol 20, it is 2 to 3 times that material, which crushes number, in step 2, takes the sieve of 60 mesh to the medicinal material after grinding
It is filtered, 80 purified water of component is added in step 3 and is mixed, water can be added in observation mixture viscosity again
Its mixture viscosity is adjusted, observes mixture viscosity with eyes in step 5, it can be sticky by adding water to adjust mixture
Degree.
Embodiment five
The composition proportion of use are as follows: 140 parts of water, 45 parts of glycerol, 20 parts of ethyl alcohol, 40 parts of hydroxyethyl cellulose, sodium acetate 60
Part, 45 parts of isopropanol, -26 20 parts of PPG-26- butylol polyether, 40 parts of Cremophor RH40,30 parts of lactic acid, triethanolamine
45 parts, 60 parts of inulin, 35 parts of alpha-glucans oligosaccharides, 25 parts of sodium citrate, 20 parts of Euglena gracilis polysaccharide, 40 parts of hydrolytic collagen, south
35 parts of melon tunning extract, 35 parts of chlorhexidine acetate, 20 parts of menthol, 20 parts of Sodium Hyaluronate cross-linked polymer, 1,2-
30 parts of pentanediol, 40 parts of rose oil and 50 parts of Fructus Citri grandis extract.
The preparation process of the present embodiment the following steps are included:
Step 1: taking medicinal material to clean, and the medicinal material of selection is placed on the pallet of balance and is weighed, and chooses most according to composition by weight
Big component；
Step 2: it takes smashed medicine raw material to be put into medicinal material pulverizer and carries out crushing and processing, smashed medicinal material is put into
It is ground in medicinal material grinder, sieve is taken to be filtered the medicinal material after grinding, the medicinal material for not passing through sieve, which is placed again into, to be ground
It is ground in grinding machine, until completely extending across sieve；
Step 3: taking smashed medicinal material to be put into medicinal material blender, and water is added and is mixed, and observation mixture is viscous
Consistency；
Step 4: after object to be mixed is thoroughly mixed, glycerol, Cremophor RH40 mixing is added into mixture respectively
Stirring, stirring are added ethyl alcohol into mixture after ten minutes, again and are stirred to obtain mixed liquor A；
Step 5: it is few that isopropanol, PPG-26- butylol polyether -26, lactic acid, alpha-glucans are separately added into mixed liquor A
Sugar, triethanolamine and sodium citrate are mixed to obtain mixed liquid B.
Step 6: hydrolytic collagen, pumpkin fermenting product extract, chlorhexidine acetate, peppermint are separately added into mixed liquid B
Alcohol, Sodium Hyaluronate cross-linked polymer, 1,2- pentanediol and Fructus Citri grandis extract are mixed, and paste is stirred into, and suppression is made
Bacterium gel.
In the present embodiment, the medicinal material that weighing is chosen in step 1 is respectively hydroxyethyl cellulose, sodium acetate, inulin, thin
Small Euglena polysaccharide and menthol, choose medicinal material peace parts by weight be respectively hydroxyethyl cellulose 40, it is sodium acetate 60, inulin 60, tiny
Euglena polysaccharide 20 and menthol 20, it is 2 to 3 times that material, which crushes number, in step 2, takes the sieve of 60 mesh to the medicinal material after grinding
It is filtered, 80 purified water of component is added in step 3 and is mixed, water can be added in observation mixture viscosity again
Its mixture viscosity is adjusted, observes mixture viscosity with eyes in step 5, it can be sticky by adding water to adjust mixture
Degree.
In summary: the bacteriostatic gel has tightening uterus, good antimicrobial effect, and curative effect long action time can be to some
The advantages of symptoms such as eczema, itch are cured, and can be protected for a long time to the skin of patient solves existing antibacterial solidifying
Glue does not have the effect in tightening uterus, and after the complete child of life, metreurysma can not restore, on female pathology women completely
The problem of making troubles.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (7)
1. a kind of bacteriostatic gel, it is characterised in that: its raw material includes water, glycerol, ethyl alcohol, hydroxyethyl cellulose, sodium acetate, isopropyl
Alcohol, PPG-26- butylol polyether -26, Cremophor RH40, lactic acid, triethanolamine, inulin, alpha-glucans oligosaccharides, citric acid
Sodium, Euglena gracilis polysaccharide, hydrolytic collagen and pumpkin fermenting product extract, each component are respectively as follows: water 80- by weight
150, glycerol 40-45, ethyl alcohol 10-20, hydroxyethyl cellulose 30-40, sodium acetate 50-60, isopropanol 35-45, PPG-26- butanol
- 26 10-20 of polyethers, Cremophor RH40 30-40, lactic acid 20-30, triethanolamine 35-45, inulin 50-60, α-Portugal are poly-
Sugared oligosaccharides 25-35, sodium citrate 15-25, Euglena gracilis polysaccharide 10-20, hydrolytic collagen 30-40 and pumpkin fermenting product extract
20-35。
2. a kind of bacteriostatic gel according to claim 1, it is characterised in that: the bacteriostatic gel further include acetic acid chlorine oneself
Fixed, menthol, Sodium Hyaluronate cross-linked polymer, 1,2- pentanediol, rose oil and Fructus Citri grandis extract, each component is by weight
Amount ratio is respectively as follows: chlorhexidine acetate 25-35, menthol 10-20, Sodium Hyaluronate cross-linked polymer 10-20,1,2- pentanediol
20-30, rose oil 30-40 and Fructus Citri grandis extract 40-50.
3. a kind of bacteriostatic gel according to claim 1, it is characterised in that: the bacteriostatic gel preparation process includes following
Step:
Step 1: taking medicinal material to clean, and the medicinal material of selection is placed on the pallet of balance and is weighed, and chooses maximum group according to composition by weight
Part；
Step 2: it takes smashed medicine raw material to be put into medicinal material pulverizer and carries out crushing and processing, smashed medicinal material is put into medicinal material
It is ground in grinder, sieve is taken to be filtered the medicinal material after grinding, the medicinal material for not passing through sieve is placed again into grinder
Middle grinding, until completely extending across sieve；
Step 3: taking smashed medicinal material to be put into medicinal material blender, and water is added and is mixed, observation mixture is sticky
Degree；
Step 4: after object to be mixed is thoroughly mixed, glycerol is added into mixture respectively, Cremophor RH40 mixing is stirred
It mixes, stirring is added ethyl alcohol into mixture after ten minutes, again and is stirred to obtain mixed liquor A；
Step 5: isopropanol, PPG-26- butylol polyether -26, lactic acid, alpha-glucans oligosaccharides, three are separately added into mixed liquor A
Ethanol amine and sodium citrate are mixed to obtain mixed liquid B.
Step 6: be separately added into mixed liquid B hydrolytic collagen, pumpkin fermenting product extract, chlorhexidine acetate, menthol,
Sodium Hyaluronate cross-linked polymer, 1,2- pentanediol and Fructus Citri grandis extract are mixed, and paste is stirred into, and are made antibacterial solidifying
Glue.
4. a kind of bacteriostatic gel according to claim 3, it is characterised in that: the medicinal material for choosing weighing in step 1
Respectively hydroxyethyl cellulose, sodium acetate, inulin, Euglena gracilis polysaccharide and menthol, choosing medicinal material peace parts by weight is respectively hydroxyl
Ethyl cellulose 40, sodium acetate 60, inulin 60, Euglena gracilis polysaccharide 20 and menthol 20.
5. a kind of bacteriostatic gel according to claim 3, it is characterised in that: it is 2 that the material in step 2, which crushes number,
To 3 times, the sieve of 60 mesh is taken to be filtered the medicinal material after grinding.
6. a kind of bacteriostatic gel according to claim 3, it is characterised in that: the component 80 that is added in step 3 purifies
Water is mixed, and water can be added again and adjust its mixture viscosity for observation mixture viscosity.
7. a kind of bacteriostatic gel according to claim 3, it is characterised in that: described observed in step 5 with eyes mixes
Object viscosity, can be by adding water to adjust mixture viscosity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910422506.4A CN110124017A (en) | 2019-05-21 | 2019-05-21 | A kind of bacteriostatic gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910422506.4A CN110124017A (en) | 2019-05-21 | 2019-05-21 | A kind of bacteriostatic gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110124017A true CN110124017A (en) | 2019-08-16 |
Family
ID=67571673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910422506.4A Pending CN110124017A (en) | 2019-05-21 | 2019-05-21 | A kind of bacteriostatic gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110124017A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329769A (en) * | 2020-02-19 | 2020-06-26 | 株洲千金药业股份有限公司 | Bacteriostatic foam lotion and preparation method thereof |
| CN111449973A (en) * | 2020-04-30 | 2020-07-28 | 西安贝迪斯可生物科技有限公司 | Foaming agent for restoring microecological balance of female vagina and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309237A (en) * | 2016-09-26 | 2017-01-11 | 杭州惠博士生物科技有限公司 | Hyaluronic acid private part care gel and preparation method thereof |
| CN106728630A (en) * | 2016-12-22 | 2017-05-31 | 广州睿森生物科技有限公司 | A kind of anti-inflammation composition and privates care product |
| CN107007515A (en) * | 2017-06-13 | 2017-08-04 | 成都珂萝瑞诗化妆品有限公司 | A kind of women secret conditioning liquid and preparation method thereof |
| CN107243017A (en) * | 2017-06-09 | 2017-10-13 | 成都珂萝瑞诗化妆品有限公司 | A kind of antibacterial balance gynecological gel and preparation method thereof |
| CN108578646A (en) * | 2018-07-17 | 2018-09-28 | 合肥霞康电子商务有限公司 | A kind of draft conditioning liquid with bacteriostasis efficacy |
| CN109078165A (en) * | 2018-10-26 | 2018-12-25 | 广东卓明仕生物科技有限公司 | A kind of composition and the preparation method and application thereof for the nursing of women privates |
| CN109602868A (en) * | 2019-02-01 | 2019-04-12 | 株洲千金药业股份有限公司 | Plant essence liquid and preparation method thereof and sanitary napkin application |
-
2019
- 2019-05-21 CN CN201910422506.4A patent/CN110124017A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309237A (en) * | 2016-09-26 | 2017-01-11 | 杭州惠博士生物科技有限公司 | Hyaluronic acid private part care gel and preparation method thereof |
| CN106728630A (en) * | 2016-12-22 | 2017-05-31 | 广州睿森生物科技有限公司 | A kind of anti-inflammation composition and privates care product |
| CN107243017A (en) * | 2017-06-09 | 2017-10-13 | 成都珂萝瑞诗化妆品有限公司 | A kind of antibacterial balance gynecological gel and preparation method thereof |
| CN107007515A (en) * | 2017-06-13 | 2017-08-04 | 成都珂萝瑞诗化妆品有限公司 | A kind of women secret conditioning liquid and preparation method thereof |
| CN108578646A (en) * | 2018-07-17 | 2018-09-28 | 合肥霞康电子商务有限公司 | A kind of draft conditioning liquid with bacteriostasis efficacy |
| CN109078165A (en) * | 2018-10-26 | 2018-12-25 | 广东卓明仕生物科技有限公司 | A kind of composition and the preparation method and application thereof for the nursing of women privates |
| CN109602868A (en) * | 2019-02-01 | 2019-04-12 | 株洲千金药业股份有限公司 | Plant essence liquid and preparation method thereof and sanitary napkin application |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329769A (en) * | 2020-02-19 | 2020-06-26 | 株洲千金药业股份有限公司 | Bacteriostatic foam lotion and preparation method thereof |
| CN111329769B (en) * | 2020-02-19 | 2024-01-16 | 株洲千金药业股份有限公司 | Antibacterial foam lotion and preparation method thereof |
| CN111449973A (en) * | 2020-04-30 | 2020-07-28 | 西安贝迪斯可生物科技有限公司 | Foaming agent for restoring microecological balance of female vagina and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103385926B (en) | Antibiosis gel for curing cervical and vaginal diseases of gynaecology | |
| CN104224923A (en) | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology | |
| CN102824308A (en) | Chitosan antibacterial filming sprayer and preparation method | |
| CN109876051A (en) | A kind of gynecological gel and preparation method thereof | |
| CN100457084C (en) | Nanometer silver type external use antibiotic gel for female external use and its prepn. method | |
| CN106109451A (en) | A kind of antibiotic preparation and preparation method thereof | |
| HUE026862T2 (en) | Combined plant extracts for use in the treatment of microbial infections | |
| CN110124017A (en) | A kind of bacteriostatic gel | |
| CN107362108A (en) | A kind of Golden flower facial mask and preparation method thereof | |
| US10478463B2 (en) | External-use medicament for cleaning and care of the ovaries, vagina, and vulva | |
| CN101744925A (en) | Chinese medicinal antibacterial lotion and preparation method thereof | |
| CN103463284B (en) | Gynecological cleaning liquid and preparation method thereof | |
| CN108685987A (en) | A kind of Chinese medicine composition and its preparation method and application | |
| CN108186738A (en) | A kind of gynaecological gel of American-cockroach-extract-containing and preparation method thereof | |
| CN107753347A (en) | A kind of hydrogel sour pomegranate powder skin care item and preparation method thereof, application | |
| CN101744926B (en) | Chinese medicinal antibacterial lotion and preparation method thereof | |
| CN110368447A (en) | A kind of gynaecology's reparation gel preparation and its preparation method and application containing sodium azulenesulfonate | |
| CN106266037B (en) | Liquid gel and preparation method thereof | |
| CN105311328A (en) | Traditional Chinese medicine composition for treating gynecological inflammation and application thereof | |
| CN112316012A (en) | Moisturizing antibacterial gel and preparation method thereof | |
| CN102462768A (en) | Female nursing solution for external use | |
| CN110664918A (en) | Conjunctival agent for preventing sperms from entering uterus and preparation method thereof | |
| CN111905030A (en) | Vagina health care gel and preparation method and application thereof | |
| CN106581172B (en) | Medicine for preventing and treating mycotic vaginitis, trichomonas vaginitis and senile vaginitis and preparation method thereof | |
| CN114533809B (en) | Vitamin E antibacterial cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190816 |