CN110368447A - A kind of gynaecology's reparation gel preparation and its preparation method and application containing sodium azulenesulfonate - Google Patents
A kind of gynaecology's reparation gel preparation and its preparation method and application containing sodium azulenesulfonate Download PDFInfo
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Abstract
The present invention provides a kind of gynaecology's reparation gel preparation and its preparation method and application containing sodium azulenesulfonate, belong to pharmaceutical technology field, gel preparation is repaired by gynaecology of the invention, it is made of the raw material of following parts by weight: 1~20 part of sodium azulenesulfonate, 40~70 parts of gel-type vehicle, 1~20 part of aloe extract, 1~20 part of common cnidium fruit P.E, 1~20 part of Salvia root P.E, 1~20 part of Leonurus extract, 0.1~1 part of nano silver.Gel preparation is repaired by gynaecology of the invention has good anti-inflammatory repair for female gynecological inflammation and erosion, is avoided that germ generates drug resistance being used for a long time, extremely slight to the irritation of human body.
Description
Technical field
The present invention relates to pharmaceutical technology field, be specifically related to a kind of gynaecology containing sodium azulenesulfonate repair gel preparation and
Preparation method and application.
Background technique
It is reported that the different degrees of infection of the adult female in the whole world about 87% gynaecological imflammation.
Gynaecological imflammation is the common disease of women, is primarily referred to as the inflammation of female sex organ, and clinical common gynaecology is scorching
Disease has vaginitis, cervicitis, pelvic inflammatory disease, endometritis etc..
The common sympton of gynaecological imflammation is mainly vulva and pruritus of vagina, and locally generation is rotten to the corn for some, with cusalgia, urodynia,
Frequent micturition, vaginal fluid increase, redness etc..Clinically it is mainly shown as itching of vulva pain, the scorching hot pain of vagina, abdominal pain；Leukorrhea amount increases
More, color is yellow or red or green or black, and character is thin or sticky or hemorrhagic or purulence or bean dregs sample or foam-like, smell
It is smelly, or stench or stench, some is also with the cold fever of fear, frequent micturition, urodynia etc..
Gynaecological imflammation is the common clinical in gynecological disease, generally caused by germ infects.Such state of an illness is longer, the state of an illness
Recurrent exerbation, the state of an illness is more obstinate, seriously affects the physical and mental health and life and work of women.
Currently, the medicament categories for the treatment of gynaecological imflammation are various, have using raw as raw material containing metronidazole, clotrimazole class antibiotic
The product of production, the direct result of this similar drug of excessive use are exactly that germ is made to generate drug resistance, destroy the restriction between vaginal flora
Relationship causes fungi growth vigorous, and treatment cycle constantly extends, and is continuously increased drug dose, and disease cannot be treated fundamentally.
Summary of the invention
The first object of the present invention be to provide a kind of antibacterial and anti-inflammatory effects it is good, reduce germ drug resistance gynaecology repair gel
Preparation.
The second object of the present invention is to provide a kind of preparation method of above-mentioned gynaecology's reparation gel preparation.
The third object of the present invention is to provide a kind of application of above-mentioned gynaecology's reparation gel preparation.
In order to realize that the first above-mentioned purpose, the present invention provide a kind of gynaecology's reparation gel preparation containing sodium azulenesulfonate,
It is made of the raw material of following parts by weight: 1~20 part of sodium azulenesulfonate, 40~70 parts of gel-type vehicle, 1~20 part of aloe extract,
1~20 part of common cnidium fruit P.E, 1~20 part of Salvia root P.E, 1~20 part of Leonurus extract, 0.1~1 part of nano silver.
Preferably, gynaecology repairs gel preparation and is made of the raw material of following parts by weight: 10 parts of sodium azulenesulfonate, gel-type vehicle
62.7 parts, 12 parts of aloe extract, 5 parts of common cnidium fruit P.E, 5 parts of Salvia root P.E, 5 parts of Leonurus extract, nano silver 0.3
Part.
Further embodiment is the solvent and 2 that gel-type vehicle is made of 10 parts of glycerol, 5 parts of propylene glycol, 43.7 parts of purified waters
The solute that part hydroxyethyl cellulose, 2 parts of xanthan gum form is made.
Preferably, gynaecology repairs gel preparation and is made of the raw material of following parts by weight: 2 parts of sodium azulenesulfonate, gel-type vehicle
40.88 parts, 15 parts of aloe extract, 12 parts of common cnidium fruit P.E, 15 parts of Salvia root P.E, 15 parts of Leonurus extract, nanometer
0.12 part of silver.
Further embodiment is the solvent and 1 that gel-type vehicle is made of 2 parts of glycerol, 2 parts of propylene glycol, 34.88 parts of purified waters
The solute that part hydroxyethyl cellulose, 1 part of xanthan gum form is made.
Preferably, gynaecology repairs gel preparation and is made of the raw material of following parts by weight: 5 parts of sodium azulenesulfonate, gel-type vehicle
44.8 parts, 20 parts of aloe extract, 10 parts of common cnidium fruit P.E, 10 parts of Salvia root P.E, 10 parts of Leonurus extract, nano silver
0.2 part.
Further embodiment is, solvent that gel-type vehicle is made of 10 parts of glycerol, 10 parts of propylene glycol, 23.8 parts of purified waters and
The solute that 0.5 part of hydroxyethyl cellulose, 0.5 part of xanthan gum form is made.
Further scheme is that common cnidium fruit P.E is extracted by natural frutus cnidii and obtained, and Salvia root P.E is by natural red
Ginseng, which is extracted, to be obtained, and Leonurus extract is extracted by natural motherwort and obtained.
By above scheme as it can be seen that the active constituent that gel preparation is repaired by gynaecology of the invention is extracted by sodium azulenesulfonate, aloe
Object, common cnidium fruit P.E, Salvia root P.E, Leonurus extract and nano silver these types material composition.
Wherein, sodium azulenesulfonate is that the extraction processing of compositae plant yellow chamomile is prepared, and has both anti-inflammatory, the tissue dual function of life
Effect, can be effectively suppressed the release of inflammatory factor, while it is newborn with epithelial cell that there is stimulation granulation to be formed, and promotes forefront in mucous membrane
The effect of parathyrine synthesis, has both anti-inflammatory and regeneration double effects effects.Sodium azulenesulfonate is made by extracted form natural plant, peace
Quan Xinggao is free of heavy metal ion, will not accumulation of poisoning cause the damage of middle area's nervous system, will not collide with other drugs
Reaction.Sodium azulenesulfonate is natural botanical source, good with epidermal cell compatibility.
Aloe extract is selected Aloe Barbadensis Miller fresh leaf to extract and is made, and has sterilization, antibacterial, anti-inflammatory, promotes wound healing
The effects of.
Common cnidium fruit P.E is that the extraction of natural frutus cnidii is made, and has significant antimycotic and mould effect.
Salvia root P.E is that the extraction of natural Radix Salviae Miltiorrhizae is made, and has function of promoting blood circulation to disperse blood clots.
Leonurus extract is that the extraction of natural motherwort is made, and has promoting blood circulation for regulating menstruation, removing blood stasis for promoting tissue regeneration, inducing diuresis to remove edema, heat-clearing
The function of removing toxic substances.
Partial size is exactly accomplished that nanoscale metallic silver simple substance, nano silver partial size are right mostly in 25 rans by nano silver
The tens of kinds of pathogenic microorganisms such as Escherichia coli, gonococcus, chlamydia trachomatis have strong inhibition and killing effect, and will not
Generate drug resistance.
Common cnidium fruit P.E that the present invention uses, Salvia root P.E, Leonurus extract are respectively corresponding natural traditional Chinese medicine
The juice being obtained by filtration again through 100 mesh filter screens after impregnating for 24 hours is mixed with the ratio of mass ratio 1:5 to 1:10 with water.This hair
The bright Sodium azulenesulfonate manufacturer used is Tianjin Dingshuo Pharmaceutical Technology Co., Ltd., aloe extract manufacturer that the present invention uses
For Yunnan Evergreen Biotechnology Co., Ltd..
It was discovered by researchers that these types of Chinese herbal medicine extract and nano silver are used in compounding, for female gynecological inflammation and
Erosion has good anti-inflammatory repair.Active constituent in gel preparation is repaired due to gynaecology of the invention and uses day
Right Chinese herbal medicine extract is compounded with nano silver, compared with the drug of traditional treatment gynaecological imflammation, woman of the invention
Section repairs gel preparation long-time service and is also avoided that germ generates drug resistance.
By using glycerol, propylene glycol, hydroxyethyl cellulose and xanthan gum can play guarantor as main gel-type vehicle
The effect of wet, lubrication and gel regulator.
In order to realize the second above-mentioned purpose, the preparation method of gel preparation is repaired by gynaecology provided by the invention, including with
Lower step:
S1, the solvent materials of gel-type vehicle are uniformly mixed, it is spare that gel-type vehicle solvent is made；
S2, the solute raw material that gel-type vehicle is added into the gel-type vehicle solvent of step S1, are mixed, are heated to 80
DEG C, high speed shear 10 minutes, it is spare that gel-type vehicle is made in shear velocity 3000-10000rpm；
S3, the step S2 gel-type vehicle prepared is cooled to room temperature, sodium azulenesulfonate and aloe extract is added, stirring is equal
It is even, it is spare；
S4, the mixture in step S3 is added in common cnidium fruit P.E, Salvia root P.E, Leonurus extract and nano silver
In, it stirs evenly, obtains gynaecology and repair gel preparation；
S5, the gynaecology's reparation gel preparation for obtaining step S4 are filling into gel tube, and one kind is obtained after packaging and contains Azulene
Finished gel preparation is repaired by the gynaecology of sodium sulfonate.
The present invention is used in compounding by a variety of Chinese herbal medicine extracts and nano silver, and the weight of each raw material of strict control is matched
Than by control feeding sequence and mixing condition, gel preparation is repaired to Escherichia coli, Candida albicans and gold by gynaecology obtained
Staphylococcus aureus has significant inhibiting effect.According to Ningbo Entry-Exit Inspection and Quarantine Bureau, third party testing agency technique center
Test, quick bacteriostatic experiment data are shown, to Escherichia coli, Candida albicans and staphylococcus aureus, gonococcus killing rate
>=98.%.It is evaluated according to " disinfection technology standard " 2002 editions " vaginal mucosa irritation strength grading ", gynaecology of the invention repairs solidifying
Glue preparation is 2.34 to the multiple vagina mucosa thorn index of the big ear rabbit of Japan, and stimulate the reaction intensity is pole minimal irritation.
In order to realize above-mentioned third purpose, gel preparation is repaired for treating and/or preventing gynaecology's disease by gynaecology of the invention
Disease.
Specific embodiment
The present invention provides a kind of gynaecology's reparation gel preparation and preparation method thereof containing sodium azulenesulfonate, which repairs solidifying
Glue preparation can be used for the treatment and/or prevention of gynecological disease, these gynecological diseases include gynaecological imflammation and erosion.
Gynaecology of the invention repairs gel preparation and is made of the raw material of following parts by weight: 1~20 part of sodium azulenesulfonate, gel
40~70 parts of matrix, 1~20 part of aloe extract, 1~20 part of common cnidium fruit P.E, 1~20 part of Salvia root P.E, motherwort mentions
Take 1~20 part of object, 0.1~1 part of nano silver.
Preferably, sodium azulenesulfonate is made by extracted form natural plant, highly-safe, is free of heavy metal ion, will not be accumulated
Poison causes the damage of middle area's nervous system, and will not collide reaction with other drugs.Sodium azulenesulfonate is natural botanical source, with table
Chrotoplast compatibility is good.
Preferably, aloe extract is selected Aloe Barbadensis Miller fresh leaf to extract and is made, and has sterilization, antibacterial, anti-inflammatory, promotes wound
The effects of mouth healing.
Preferably, common cnidium fruit P.E is that the extraction of natural frutus cnidii is made, and has significant antimycotic and mould effect.
Preferably, Salvia root P.E is that the extraction of natural Radix Salviae Miltiorrhizae is made, and has function of promoting blood circulation to disperse blood clots.
Preferably, Leonurus extract is that the extraction of natural motherwort is made, and there is promoting blood circulation for regulating menstruation, removing blood stasis for promoting tissue regeneration, diuresis to disappear
Swollen, clearing heat and detoxicating function.
Embodiment one
In the present embodiment, the gynaecology of every 100g, which repairs in gel preparation, includes: sodium azulenesulfonate 10g, gel-type vehicle
62.7g, aloe extract 12g, common cnidium fruit P.E 5g, Salvia root P.E 5g, Leonurus extract 5g, nano silver 0.3g.
Gel-type vehicle includes 10g glycerol, 5g propylene glycol, 43.7g purified water, 2g hydroxyethyl cellulose, 2g xanthan gum.
The gynaecology of the present embodiment repair the preparation method of gel preparation the following steps are included:
S1, glycerol, propylene glycol, purified water are uniformly mixed, it is spare that gel-type vehicle solvent is made.
S2, hydroxyethyl cellulose and xanthan gum are added into the gel-type vehicle solvent of step S11, are mixed, are heated to
80 DEG C, high speed shear 10 minutes, it is spare that gel-type vehicle is made.Wherein shear velocity is 3000-10000rpm, preferably
5000rpm。
S3, the step S12 gel-type vehicle prepared is cooled to room temperature, sodium azulenesulfonate and aloe extract is added, stirring is equal
It is even, it is spare.
S4, the mixture in step S3 is added in common cnidium fruit P.E, Salvia root P.E, Leonurus extract and nano silver
In, it stirs evenly, obtains gynaecology and repair gel preparation.
S5, the gynaecology's reparation gel preparation for obtaining S14 are filling into gel tube, and one kind is obtained after packaging and contains Azulene sulfonic acid
Finished gel preparation is repaired by the gynaecology of sodium.
The present embodiment is obtained to repair gel preparation containing sodium azulenesulfonate gynaecology, and through clinical trial, 20 people of Subject Population suffers from
There is different degrees of vaginitis, and with cervical erosion phenomenon, is repaired using the gynaecology containing sodium azulenesulfonate of embodiment one solidifying
Glue preparation, daily using after one, three days, inflammation is clearly better, and after 15 days, inflammation disappears, and cervical erosion is repaired intact.
Embodiment two
In the present embodiment, the gynaecology of every 100g, which repairs in gel preparation, includes: sodium azulenesulfonate 2g, gel-type vehicle 4, nanometer
Silver-colored 0.3g, aloe extract 15g, common cnidium fruit P.E 12g, Salvia root P.E 15g, Leonurus extract 15g, nano silver
0.12g。
Gel-type vehicle includes 2g glycerol, 2g propylene glycol, 34.88g purified water, 1g hydroxyethyl cellulose, 1g xanthan gum.
The preparation method that gel preparation is repaired by the gynaecology of the present embodiment is identical as the preparation method of embodiment one.
Gel preparation is repaired by the present embodiment gynaecology containing sodium azulenesulfonate obtained, through clinical trial, 15 people of Subject Population,
With different degrees of cervicitis and with cervical erosion phenomenon, wherein 7 uterine neck are slightly rotten to the corn, 5 uterine neck, 2 degree of erosions, 3
3 degree of erosions of uterine neck repair gel preparation using the gynaecology containing sodium azulenesulfonate of embodiment two, after using one, three days daily,
Inflammation is clearly better, and after 15 days, inflammation disappears, and cervical erosion is clearly better, after 45 days, 3 degree of erosion patients' cervical erosion of uterine neck
It cures, repairs intact.
Embodiment three
In the present embodiment, the gynaecology of every 100g, which repairs in gel preparation, includes: sodium azulenesulfonate 5g, gel-type vehicle 44.8g,
Aloe extract 20g, common cnidium fruit P.E 10g, Salvia root P.E 10g, Leonurus extract 10g, nano silver 0.2g.
Gel-type vehicle includes 10g glycerol, 10g propylene glycol, 23.8g purified water, 0.5g hydroxyethyl cellulose, 0.5g xanthan
Glue.
The preparation method that gel preparation is repaired by the gynaecology of the present embodiment is identical as the preparation method of embodiment one.
Gel preparation is repaired by the present embodiment gynaecology containing sodium azulenesulfonate obtained, through clinical trial, 18 people of Subject Population,
With different degrees of cervicitis and with cervical erosion phenomenon, wherein 10 uterine neck are slightly rotten to the corn, 6 uterine neck, 2 degree of erosions, 2
Example 3 degree of erosions of uterine neck repair gel preparation using the gynaecology containing sodium azulenesulfonate of embodiment three, use one, three days daily
Afterwards, inflammation is clearly better, and after 15 days, inflammation disappears, and cervical erosion is clearly better, and after 45 days, 3 degree of erosion patients' uterine neck of uterine neck are rotten
Rotten healing is repaired intact.
Finally it is emphasized that the above description is only a preferred embodiment of the present invention, it is not intended to restrict the invention, it is right
For those skilled in the art, the present invention can have various change and change, all within the spirits and principles of the present invention,
Any modification, equivalent substitution, improvement and etc. done, should all be included in the protection scope of the present invention.
Claims (10)
1. gel preparation is repaired by a kind of gynaecology containing sodium azulenesulfonate, it is characterised in that:
It is made of the raw material of following parts by weight:
2. gel preparation is repaired by gynaecology according to claim 1, it is characterised in that:
It is made of the raw material of following parts by weight:
3. gel preparation is repaired by gynaecology according to claim 2, it is characterised in that:
Solvent and 2 parts of hydroxyethyl celluloses that the gel-type vehicle is made of 10 parts of glycerol, 5 parts of propylene glycol, 43.7 parts of purified waters,
The solute of 2 parts of xanthan gum composition is made.
4. gel preparation is repaired by gynaecology according to claim 1, it is characterised in that:
It is made of the raw material of following parts by weight:
5. gel preparation is repaired by gynaecology according to claim 4, it is characterised in that:
Solvent and 1 part of hydroxyethyl cellulose that the gel-type vehicle is made of 2 parts of glycerol, 2 parts of propylene glycol, 34.88 parts of purified waters,
The solute of 1 part of xanthan gum composition is made.
6. gel preparation is repaired by gynaecology according to claim 1, it is characterised in that:
It is made of the raw material of following parts by weight:
7. gel preparation is repaired by gynaecology according to claim 6, it is characterised in that:
The solvent and 0.5 part of hydroxy ethyl fiber that the gel-type vehicle is made of 10 parts of glycerol, 10 parts of propylene glycol, 23.8 parts of purified waters
The solute that element, 0.5 part of xanthan gum form is made.
8. gel preparation is repaired by gynaecology according to any one of claims 1 to 7, it is characterised in that:
The common cnidium fruit P.E is extracted by natural frutus cnidii and is obtained；
The Salvia root P.E is extracted by natural Radix Salviae Miltiorrhizae and is obtained；
The Leonurus extract is extracted by natural motherwort and is obtained.
9. the preparation method that gel preparation is repaired by gynaecology as claimed in any one of claims 1 to 8, which is characterized in that including with
Lower step:
S1, the solvent materials of the gel-type vehicle are uniformly mixed, it is spare that gel-type vehicle solvent is made；
S2, the solute raw material that the gel-type vehicle is added into the gel-type vehicle solvent of step S1 are mixed, are heated to
80 DEG C, high speed shear 10 minutes, it is spare that gel-type vehicle is made in shear velocity 3000-10000rpm；
S3, the gel-type vehicle for preparing step S2 are cooled to room temperature, and the sodium azulenesulfonate and the aloe extract is added,
It stirs evenly, it is spare；
S4, step is added in the common cnidium fruit P.E, the Salvia root P.E, the Leonurus extract and the nano silver
It in mixture in S3, stirs evenly, obtains the gynaecology and repair gel preparation；
S5, the gynaecology reparation gel preparation for obtaining step S4 are filling into gel tube, and one kind is obtained after packaging and contains Azulene
Finished gel preparation is repaired by the gynaecology of sodium sulfonate.
10. gel preparation is repaired in treatment and/or prophylaxis of gynaecological disorders by a kind of gynaecology as claimed in any one of claims 1 to 8
In application.
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| CN201910734638.0A CN110368447A (en) | 2019-08-09 | 2019-08-09 | A kind of gynaecology's reparation gel preparation and its preparation method and application containing sodium azulenesulfonate |
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| CN201910734638.0A CN110368447A (en) | 2019-08-09 | 2019-08-09 | A kind of gynaecology's reparation gel preparation and its preparation method and application containing sodium azulenesulfonate |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101952799B1 (en) | 2014-12-22 | 2019-02-27 | 후아웨이 테크놀러지 컴퍼니 리미티드 | Polar code encoding method and encoding device |
| CN110787109A (en) * | 2019-12-07 | 2020-02-14 | 路书刚 | Preparation containing peptide for repairing and tightening |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102018703A (en) * | 2009-09-11 | 2011-04-20 | 天津市顶硕科贸有限公司 | Azulene sulfonate-containing gynaecological special lotion |
| CN102397444A (en) * | 2011-11-19 | 2012-04-04 | 西北农林科技大学 | Nano-grade gynaecological lotion and preparation method thereof |
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| CN102018703A (en) * | 2009-09-11 | 2011-04-20 | 天津市顶硕科贸有限公司 | Azulene sulfonate-containing gynaecological special lotion |
| CN102397444A (en) * | 2011-11-19 | 2012-04-04 | 西北农林科技大学 | Nano-grade gynaecological lotion and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101952799B1 (en) | 2014-12-22 | 2019-02-27 | 후아웨이 테크놀러지 컴퍼니 리미티드 | Polar code encoding method and encoding device |
| CN110787109A (en) * | 2019-12-07 | 2020-02-14 | 路书刚 | Preparation containing peptide for repairing and tightening |
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Application publication date: 20191025 |