CN106540046A - A kind of vagina antibiosis pharmaceutical gel - Google Patents
A kind of vagina antibiosis pharmaceutical gel Download PDFInfo
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- CN106540046A CN106540046A CN201611194297.5A CN201611194297A CN106540046A CN 106540046 A CN106540046 A CN 106540046A CN 201611194297 A CN201611194297 A CN 201611194297A CN 106540046 A CN106540046 A CN 106540046A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Alternative & Traditional Medicine (AREA)
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Abstract
The present invention provides a kind of vagina antibiosis pharmaceutical gel, is made up of the raw material of following weight portion：68 weight portion of kuh-seng, 10 12 weight portion of safflower, 7 13 weight portion of dragon's blood, 46 weight portion of modification of chitosan, 24 weight portion of Polycarbophil, 24 weight portion of tea tree ethereal oil, 36 weight portion of triethanolamine, 24 weight portion of emulsifying agent, 69 weight portion of Carbomer, 8 10 weight portion of frutus cnidii, 12 weight portion of methyl p-hydroxybenzoate；Compared with prior art, the present invention has following beneficial effect：Can quick anti-inflammatory anti-itch, dispelling abnormal flavor, multiple pathogens cross-infection in blocking sexual life; moist yin-nourishing, nurses one's health flora, balancing alkalinity acidity; protection and reparation vagina mucosa; contraction is compacted mobile pleat, increases elasticity and susceptibility, real meaning from basic conditioning; lift Reproductive Performance; prevention of inflammation recurrent exerbation, recovery occurs without treatment, while physiological function can be lifted.
Description
Technical field
The present invention is a kind of vagina antibiosis pharmaceutical gel, belongs to pharmaceutical synthesis field.
Background technology
As social development, the life style of people and behavior are constantly changing, various gynecological diseases, such as genital tract
The illness rate of infection, menstrual disorder and mammary gland disease etc. is gradually increasing.Gynecological infectious diseases are used as a class common disease and many
Morbidity, particularly colpomycosis, cervical erosion and the senile vahinitis incidence of disease are very high, and various chronic cervical diseases are even more
Vast female friend is annoying throughout the year.
For example, pure VVC (SVVC) is a kind of excessively numerous in intravaginal by candidiasis
The gynaecology's infectious diseases in genital tract grown and cause, the most common are candida albicans infection, and illness rate accounts for Childbearing woman
Woman 5%.SVVC is easily recurred before and after menstrual period, and the recurrence rate after treating is 5%～10%.Research recently (Liu Chaohui,
Liao Qinping. Chinese vagina infection diagnosis of disease strategy [M]. Beijing:People's Medical Officer Press, 2009.) shows, SVVC's sends out
Raw disorderly with intravaginal microenvironment and imbalance has a direct relation, intravaginal sour environment is stable with destruction that is balancing be it is main because
Element.As Candida albicans is conditioned pathogen, its optimum pH value of growth is 5.5, when the faintly acid of vagina is changed into
After pH5.5, the bacterium amount reproduction causes vaginitis symptom.In recent years relevant report also mentions vagina environment with colpitic pass
System, but it is often not enough.Such as with alkaline solution rinse (Yao Caidi, Cui Mingxia. external application mildew making plain piece and vaginal scouring treatment
The clinical observation [J] of VVC. Gansu medicine, 2010.), though temporarily changing internal pH value, make white
Environment of the candida albicans in growing, but due to destroying the weakly acidic environment of normal vagina, it is easily caused infection.
For Gynecological cervical and the early treatment of vaginal disease, general way is remained and uses washing lotion, to change bacterium
In the growing environment of vagina.But various washing lotions can also kill the bacterium vaginae beneficial to body while germ is killed, break
Bad intravaginal acid-base balance environment, Long-Time Service will substantially reduce immunity, increase the chance of bacteria infection again.Also
A little oral medications for gynaecological imflammation, but these oral medications are that menses liquid is recycled into vagina position kill bacterium, are risen
The effect time is slower, needs long-term taking effective, and toxic and side effect is big.So, the treatment of Gynecological cervical and vaginal disease is excellent
Local application is selected, but, existing vagina externally applied drug bactericidal effect is poor, and excitant is big, easily repeatedly, there is also allergic
Phenomenon, therapeutic effect is preferable not to the utmost.
Above-mentioned situation shows, the drug side-effect of existing treatment gynaecologic vaginal disease is big, and curative effect is not good enough, cause patient according to
Bad property is stronger, is unfavorable for the wound repair of vast gynecological disease patient physiology and psychology.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the present invention to provide a kind of vagina antibiosis pharmaceutical gel, with solution
The problem proposed in stating background technology.
To achieve these goals, the present invention is by the following technical solutions realizing：A kind of vagina antibiosis are medicinal solidifying
Glue, is made up of the raw material of following weight portion：Kuh-seng 6-8 weight portions, safflower 10-12 weight portions, dragon's blood 7-13 weight portions, be modified shell
Glycan 4-6 weight portions, Polycarbophil 2-4 weight portions, tea tree ethereal oil 2-4 weight portions, triethanolamine 3-6 weight portions, emulsifying agent 2-4
Weight portion, Carbomer 6-9 weight portions, frutus cnidii 8-10 weight portions, methyl p-hydroxybenzoate 1-2 weight portions.
Further, during the emulsifying agent is lauryl sodium sulfate, tween, sapn, stearic acid and triethanolamine
Mix for one or more.
Further, the tea tree ethereal oil be contained within to Meng's ethene, dipentene, limonene, cineol, sesame oil brain and
Anisoxide.
Further, oxirane and ammoniacal liquor are sent in reactor, in reaction temperature 30-40 DEG C, reaction pressure
Under 70.9-304kPa, carry out condensation reaction and generate monoethanolamine, diethanol amine, triethanolamine mixed liquor, the Jing at 90-120 DEG C
After dehydration concentration, sending into three vacuum rectification towers carries out vacuum distillation, intercepts cut by different boiling, then can obtain three in raw material
Monoethanolamine.
Further, elongated cylindrical is taken, branch, long 10～750px, the legume of 1～162.5px of diameter are often arranged at bottom
The dry root of kuh-seng, removes retained root head, and size is separate, cleans, be dipped to about sixty percent it is saturating when, run through, cut sheet, be dried, put
Enter in crushing container and crush, cross 50 mesh sieves, sieve to obtain kuh-seng in raw material.
Further, take orange red, floral tube is narrow thin, and tip 5 splits, and sliver is narrow linear, the safflower of flower pesticide yellow, cleans, from
So dry, be dried, be put in crushing container and crush, cross 50 mesh sieves, sieve to obtain safflower in raw material.
Beneficial effects of the present invention：A kind of vagina antibiosis pharmaceutical gel of the present invention, tea tree ethereal oil is to Staphylococcus aureus
Bacterium, Escherichia coli, Candida albicans are acted on 2 minutes, and bacteriostasis rate is up to 100%, it is ensured that to bacterial vaginitis and mycotic
Vaginitis has most high inhibition effect.
Borneol can with heat-clearing and damp-drying drug, restrain it is antipruritic, removing toxic substances desinsection, swelling and pain relieving.
Carbomer plays drug effect uniform, control and is sustained and make as medicine frame is carried by various composition suspended dispersed in solvent
With.
The gel of the present invention, can quick anti-inflammatory anti-itch, dispelling abnormal flavor, in blocking sexual life, multiple pathogens intersect and feel
Contaminate, moisten yin-nourishing, nurse one's health flora, balancing alkalinity acidity, protection and reparation vagina mucosa, shrink the mobile pleat that compacts, increase elasticity
And susceptibility, real meaning from basic conditioning, lift Reproductive Performance, prevention of inflammation recurrent exerbation, recovery occurs without treatment, while can be with
Lift physiological function.
Specific embodiment
Technological means, creation characteristic, reached purpose and effect to make present invention realization is easy to understand, with reference to
Specific embodiment, is expanded on further the present invention.
The present invention provides a kind of technical scheme：A kind of vagina antibiosis pharmaceutical gel, is made up of the raw material of following weight portion：It is bitter
Ginseng 6-8 weight portions, safflower 10-12 weight portions, dragon's blood 7-13 weight portions, modification of chitosan 4-6 weight portions, Polycarbophil 2-4 weights
Amount part, tea tree ethereal oil 2-4 weight portions, triethanolamine 3-6 weight portions, emulsifying agent 2-4 weight portions, Carbomer 6-9 weight portions, cnidium monnieri
Sub- 8-10 weight portions, methyl p-hydroxybenzoate 1-2 weight portions.
Emulsifying agent is one or more mixing in lauryl sodium sulfate, tween, sapn, stearic acid and triethanolamine
Form.
Tea tree ethereal oil is contained within to Meng's ethene, dipentene, limonene, cineol, sesame oil brain and anisoxide.
Oxirane and ammoniacal liquor are sent in reactor, in reaction temperature 30-40 DEG C, reaction pressure 70.9-304kPa
Under, carry out condensation reaction and generate monoethanolamine, diethanol amine, triethanolamine mixed liquor, at 90-120 DEG C Jing after dehydration concentration,
Sending into three vacuum rectification towers carries out vacuum distillation, intercepts cut by different boiling, then can obtain the triethanolamine in raw material.
Take elongated cylindrical, branch often arranged at bottom, long 10～750px, the legume kuh-seng of 1～162.5px of diameter it is dry
Dry, remove retained root head, size is separate, clean, be dipped to about sixty percent it is saturating when, run through, cut sheet, be dried, be put into crushing and hold
Crush in device, cross 50 mesh sieves, sieve to obtain kuh-seng in raw material.
Take orange red, floral tube is narrow thin, and tip 5 splits, and sliver is narrow linear, the safflower of flower pesticide yellow, cleans, dries naturally, does
It is dry, it is put in crushing container and crushes, cross 50 mesh sieves, sieves to obtain safflower in raw material.
As one embodiment of the present of invention：Tea tree ethereal oil is made to staphylococcus aureus, Escherichia coli, Candida albicans
With 2 minutes, bacteriostasis rate was up to 100%, it is ensured that to bacterial vaginitis and colpomycosis with most high inhibition effect.
Borneol can with heat-clearing and damp-drying drug, restrain it is antipruritic, removing toxic substances desinsection, swelling and pain relieving.
Carbomer plays drug effect uniform, control and is sustained and make as medicine frame is carried by various composition suspended dispersed in solvent
With.
The gel of the present invention, can quick anti-inflammatory anti-itch, dispelling abnormal flavor, in blocking sexual life, multiple pathogens intersect and feel
Contaminate, moisten yin-nourishing, nurse one's health flora, balancing alkalinity acidity, protection and reparation vagina mucosa, shrink the mobile pleat that compacts, increase elasticity
And susceptibility, real meaning from basic conditioning, lift Reproductive Performance, prevention of inflammation recurrent exerbation, recovery occurs without treatment, while can be with
Lift physiological function.
As one embodiment of the present of invention：15 rats are divided into 3 groups, respectively ipll00mg/kg inventive gels, hydrogenation
Cortisone 20mg/kg and physiological saline.30 minutes after administration, in left and right foot plantar, sc2.5% formalins 0.05ml cause scorching, cause
1.3.5.7.24 hours after inflammation, for point swollen thickness of chi measurement rat foot, and compare with the swollen thickness of the foot before inflammation is caused, each medicine of calculating
The foot swelling rate of thing group different time.As a result prove that inventive gel PARA FORMALDEHYDE PRILLS(91,95) foot swelling has obvious inhibiting effect, in the same manner may be used
Being inferred to inventive gel has preferable anti-inflammatory effects.
As one embodiment of the present of invention：By the pharmaceutical gel of the present invention by ear of maize auxiliary, place to intravaginal, just
The step of applying medicinal lotion or ointment can be completed, it is easy to use, nurse one's health from basic, lifting Reproductive Performance, prevention of inflammation recurrent exerbation, recovery occurs without treatment,
Physiological function can be lifted simultaneously.
The general principle and principal character and advantages of the present invention of the present invention are had been shown and described above, for this area skill
For art personnel, it is clear that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and in the spirit without departing substantially from the present invention or
In the case of essential characteristic, the present invention can be realized in other specific forms.Therefore, no matter from the point of view of which point, all should be by
Embodiment regards exemplary as, and be it is nonrestrictive, the scope of the present invention by claims rather than on state
Bright restriction, it is intended that all changes in the implication and scope of the equivalency of claim that will fall are included in the present invention
It is interior.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.
Claims (6)
1. a kind of vagina antibiosis pharmaceutical gel, it is characterised in that：It is made up of the raw material of following weight portion：Kuh-seng 6-8 weight portions, it is red
Flower 10-12 weight portions, dragon's blood 7-13 weight portions, modification of chitosan 4-6 weight portions, Polycarbophil 2-4 weight portions, tea tree ethereal oil 2-
4 weight portions, triethanolamine 3-6 weight portions, emulsifying agent 2-4 weight portions, Carbomer 6-9 weight portions, frutus cnidii 8-10 weight portions are right
Methyl hydroxybenzoate 1-2 weight portions.
2. a kind of vagina antibiosis pharmaceutical gel according to claim 1, it is characterised in that：The emulsifying agent is dodecyl
One or more in sodium sulphate, tween, sapn, stearic acid and triethanolamine is mixed.
3. a kind of vagina antibiosis pharmaceutical gel according to claim 1, it is characterised in that：It is right that the tea tree ethereal oil is contained within
Meng's ethene, dipentene, limonene, cineol, sesame oil brain and anisoxide.
4. a kind of vagina antibiosis pharmaceutical gel according to claim 1, it is characterised in that：Oxirane and ammoniacal liquor are sent
Enter in reactor, under reaction temperature 30-40 DEG C, reaction pressure 70.9-304kPa, carry out condensation reaction generate monoethanolamine,
Diethanol amine, triethanolamine mixed liquor, at 90-120 DEG C Jing after dehydration concentration, sending into three vacuum rectification towers carries out decompression steaming
Evaporate, cut is intercepted by different boiling, then can obtain the triethanolamine in raw material.
5. a kind of vagina antibiosis pharmaceutical gel according to claim 1, it is characterised in that：Take elongated cylindrical, bottom Chang You
Branch, long 10～750px, the dry root of the legume kuh-seng of 1～162.5px of diameter remove retained root head, and size is separate,
Clean, be dipped to about sixty percent it is saturating when, run through, cut sheet, be dried, be put in crushing container and crush, cross 50 mesh sieves, sieve to obtain raw material
In kuh-seng.
6. a kind of vagina antibiosis pharmaceutical gel according to claim 1, it is characterised in that：Take orange red, floral tube is narrow thin, first
End 5 is split, and sliver is narrow linear, the safflower of flower pesticide yellow, cleans, dries naturally, is dried, and crushes, cross 50 in being put into crushing container
Mesh sieve, sieves to obtain safflower in raw material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611194297.5A CN106540046A (en) | 2016-12-21 | 2016-12-21 | A kind of vagina antibiosis pharmaceutical gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611194297.5A CN106540046A (en) | 2016-12-21 | 2016-12-21 | A kind of vagina antibiosis pharmaceutical gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106540046A true CN106540046A (en) | 2017-03-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611194297.5A Pending CN106540046A (en) | 2016-12-21 | 2016-12-21 | A kind of vagina antibiosis pharmaceutical gel |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112316050A (en) * | 2020-11-09 | 2021-02-05 | 杭州宏果科技有限公司 | Antibacterial nursing lotion and application thereof |
| CN112999294A (en) * | 2019-12-19 | 2021-06-22 | 陕西康乐实业有限公司 | Soft gel and preparation method and application thereof |
| CN113499403A (en) * | 2021-07-13 | 2021-10-15 | 西安浩然药业有限责任公司 | Formula and preparation method of gynecological traditional Chinese medicine pad |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688182A (en) * | 2012-06-04 | 2012-09-26 | 王洪明 | Vagina pH buffer antibacterial gel and preparation method thereof |
-
2016
- 2016-12-21 CN CN201611194297.5A patent/CN106540046A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688182A (en) * | 2012-06-04 | 2012-09-26 | 王洪明 | Vagina pH buffer antibacterial gel and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112999294A (en) * | 2019-12-19 | 2021-06-22 | 陕西康乐实业有限公司 | Soft gel and preparation method and application thereof |
| CN112316050A (en) * | 2020-11-09 | 2021-02-05 | 杭州宏果科技有限公司 | Antibacterial nursing lotion and application thereof |
| CN113499403A (en) * | 2021-07-13 | 2021-10-15 | 西安浩然药业有限责任公司 | Formula and preparation method of gynecological traditional Chinese medicine pad |
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Application publication date: 20170329 |