CN101347541B - Medicament for treating gynecology disease and dermatopathy and preparation thereof - Google Patents
Medicament for treating gynecology disease and dermatopathy and preparation thereof Download PDFInfo
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- CN101347541B CN101347541B CN2007100291740A CN200710029174A CN101347541B CN 101347541 B CN101347541 B CN 101347541B CN 2007100291740 A CN2007100291740 A CN 2007100291740A CN 200710029174 A CN200710029174 A CN 200710029174A CN 101347541 B CN101347541 B CN 101347541B
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Abstract
The invention discloses a medicine for treating gynecological diseases and skin diseases and a preparation method thereof. The medicine is a Chinese patent drug which is prepared by the raw materials of phellodendron, radix sophorae flavescentis, common cnidium fruit, rhizoma atractylodis, honeysuckle flower, cortex dictamni, fructus kochiae and rehmanniae radix according to a certain preparation technique. By adopting the common local Chinese herbal materials as raw materials, the medicine of the invention has low cost; furthermore, the medicine of the invention has the efficacies of clearing away heat, eliminating dampness, dispelling wind, killing parasites, diminishing inflammation and relieving itching and can achieve good curative effect. Moreover, the medicine of the invention has the advantages of easy preparation, low cost and significant curative effect, thus being applicable to the treatment of pruritus vulvae, vaginitis, cervicitis, eczema scroti and verruca acuminate which are caused by various pathogenic bacteria and skin diseases caused by a variety of fungus.
Description
Technical field:
The present invention relates to a kind of treatment gynaecopathia, dermopathic medicine and preparation method thereof, be used for the treatment of various germ vulva prurituss, vaginitis, cervicitis, eczema scrotum, condyloma acuminatum and various fungus-caused dermatosis.
Background technology:
Vulva pruritus, vaginitis, cervicitis are common gynecological diseases, and the general especially commonly encountered diseases of eczema scrotum, condyloma acuminatum and other dermatomycosiss, above-mentioned disease is often caused by antibacterial, mycete, infusorian and other funguses that the touching easy recurrence of the course of disease brings very big misery to the patient.More existing in the market external Chinese patent medicines, but most indication is narrower, and treatment has certain limitation, and mostly is women's use.The medicine that is usually used in treating gynecological inflammation mainly contains metronidazole, though these medicines have certain curative effect, also exist following problem: vagina is prone to dry and astringent, burn feeling after the medication, and long-time the application is prone to drug resistance.Therefore develop and a kind ofly can reduce the outer genital system infection of sickness rate, defence women and male; But develop a kind of kill bacteria and virus, degree of safety is high, and can be very necessary for the external used medicine that the men and women uses, and also is very to be badly in need of.
Summary of the invention:
The objective of the invention is at above-mentioned situation, invent a kind of various germ vulva prurituss, vaginitis, cervicitis, eczema scrotum, condyloma acuminatum and various fungus-caused dermopathic medicine of being used for the treatment of.This medicine is formed by multiple Chinese herbal medicine configuration, property of medicine gentleness, and abnormal smells from the patient fragrance, refrigerant comfortable after the medication, antipruritic effect is obvious, no dry and astringent and burn feeling, no dependence.
The present invention is analyzing on a large amount of ancient prescriptions, proved recipe, folk prescription and the basis of modern medicine to the pharmacological research conclusion of relevant Chinese herbal medicine, traditional theory according to Chinese medicine, with heat clearing and damp drying, wind dispelling insecticide, anti-inflammatory anti-itch is the Therapeutic Principle, adopted the multiple Chinese herbal medicine that has kill bacteria, mycete, infusorian and other funguses of inhibition according to pharmacological research in the prescription, its synergism, efficacy of a drug drug effect improves more.
For achieving the above object, the present invention is by the following technical solutions:
The present invention relates to a kind of treatment gynaecopathia, dermopathic medicine and preparation method thereof, it is made by following raw materials by weight percent medicine: Cortex Phellodendri 15%～60%, Radix Sophorae Flavescentis 8%～40%, Fructus Cnidii 5%～25%, Rhizoma Atractylodis 5%～25%, Flos Lonicerae 5%～20%, Cortex Dictamni 0%～20%, the Fructus Kochiae 0%～20%, the Radix Rehmanniae 0%～20%.
The best proportioning of described crude drug is: Cortex Phellodendri 32%, Radix Sophorae Flavescentis 19%, Fructus Cnidii 11%, Rhizoma Atractylodis 11%, Flos Lonicerae 9%, Cortex Dictamni 6%, the Fructus Kochiae 6%, the Radix Rehmanniae 6%.
The preparation method of medicine of the present invention is as follows: get Cortex Phellodendri 15%～60%, Radix Sophorae Flavescentis 8%～40%, Fructus Cnidii 5%～25%, Rhizoma Atractylodis 5%～25%, Flos Lonicerae 5%～20%, Cortex Dictamni 0%～20%, the Fructus Kochiae 0%～20%, the Radix Rehmanniae 0%～20%, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate, being evaporated to relative density is the clear paste of 1.20～1.25 (60 ℃), adding ethanol makes and contains alcohol amount and reach 60%～70%, left standstill 24 hours, filter, reclaim ethanol.Directly or indirectly add pharmaceutically acceptable excipient through conventional operation, make in lotion, suppository, spray, gel, the vagina effervescence any again.
The best approach in above-mentioned preparation method is as follows:
Get Cortex Phellodendri 32%, Radix Sophorae Flavescentis 19%, Fructus Cnidii 11%, Rhizoma Atractylodis 11%, Flos Lonicerae 9%, Cortex Dictamni 6%, the Fructus Kochiae 6%, the Radix Rehmanniae 6%, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter merging filtrate, being evaporated to relative density is the clear paste of 1.20～1.25 (60 ℃), adds ethanol and makes and contain alcohol amount and reach 60%～70%, leaves standstill 24 hours, filter, reclaim ethanol, add water to ormal weight, add benzoic acid, filter, promptly.
Pharmaceutical dosage form of the present invention is a said exterior-applied formulation on the pharmaceutics, can be that the present invention sends out the lotion stating raw material and corresponding medicinal adjuvant and make through conventional technology, suppository, spray, gel, vagina effervescence etc.
The present invention is based on Cortex Phellodendri, and totally eight flavor Chinese medicines are formed.Wherein:
Cortex Phellodendri, heat clearing and damp drying, tonifying YIN the kidney invigorating, eliminating fire and detoxication.Be applicable to diseases such as urinary tract infection, prostatitis, dysentery, enteritis, damp-heat vaginal discharge, pyretic stranguria are had blood in stool, anal fistula.Multiple malignant bacteria there is very strong inhibitory action,, staphylococcus aureus is also had very strong inhibitory action as dysentery bacterium, streptococcus pneumoniae, streptococcus, diphtheria corynebacterium are had stronger bactericidal action.
Radix Sophorae Flavescentis, energy heat clearing and damp drying, wind dispelling insecticide.Be used to have blood in stool, urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin are itched, trichomonal vaginitis.
Fructus Cnidii, have dispel the wind, dampness, Anti-Puritic and insecticidal effect, be used for cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago, external treatment vulval eczema, pudendum pruritus due to damp pathogen scabies, trichomonal vaginitis etc.
Rhizoma Atractylodis have dampness, dispel the wind, the effect of cold expelling.Modern pharmacology studies have shown that, Rhizoma Atractylodis have unique chemical composition and significant pharmacologically active, has effects such as antiinflammatory, antibiotic, sterilization.
Flos Lonicerae, heat-clearing and toxic substances removing, wind-heat dissipating has in various degree inhibitory action to various pathogenic bacterias, as staphylococcus aureus, escherichia coli, dysentery bacterium etc.; The bacillus pyocyaneus endogenous toxin is have tangible antagonism.
Cortex Dictamni, tool heat clearing and damp drying, the detoxicating functions that dispels the wind, pharmacological evaluation proves that it has effects such as antibiotic, analgesic, antiinflammatory and immunosuppressant.
The Fructus Kochiae has heat-clearing and toxic substances removing, diuretic dehumidifying, the merit of sterilizing and itch-relieving.
The Radix Rehmanniae, heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst.
The clinical observation result of the test: lotion of the present invention has cleaning, sterilization and antiinflammatory, itching-relieving action to perineum and vagina, cervix uteri, skin, mucosa.According to clinical statistics, effective percentage is more than 93%, and obvious effective rate is 85%.After the patient uses this product, can improve the alleviation clinical symptoms at short notice, patient's clinical sign is eliminated by section within a certain period of time, and heat-clearing and toxic substances removing, the dampness removing to stop itchin exact efficacy of this product is described.In the clinical observation process, do not find that the patient has untoward reaction and anaphylaxis, to the medicine no dependence, illustrate that this product is safe.No matter this product adopts stock solution to be coated with to wipe away or dilutes back demibain or vagina lavation, all can obtain good efficacy to treatment vulva pruritus, vaginitis, cervicitis, eczema scrotum, condyloma acuminatum and various fungus-caused dermatosis.
The specific embodiment:
Get Cortex Phellodendri 32%, Radix Sophorae Flavescentis 19%, Fructus Cnidii 11%, Rhizoma Atractylodis 11%, Flos Lonicerae 9%, Cortex Dictamni 6%, the Fructus Kochiae 6%, the Radix Rehmanniae 6%, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter merging filtrate, being evaporated to relative density is the clear paste of 1.20～1.25 (60 ℃), adds ethanol and makes and contain alcohol amount and reach 60%～70%, leaves standstill 24 hours, filter, reclaim ethanol, add water to ormal weight, add benzoic acid, filter, promptly.
Medicine of the present invention also routinely preparation process be prepared into and directly act on affected part, other external preparation easy to use, as suppository, spray, gel, vagina effervescence etc.
Claims (5)
1. a treatment is characterized in that by various germ vulva prurituss, vaginitis, cervicitis, eczema scrotum, condyloma acuminatum and various fungus-caused dermopathic external used medicine this medicine is to be made by the following raw materials by weight percent medicine: Cortex Phellodendri 15%～60%, Radix Sophorae Flavescentis 8%～40%, Fructus Cnidii 5%～25%, Rhizoma Atractylodis 5%～25%, Flos Lonicerae 5%～20%, Cortex Dictamni 0%～20%, the Fructus Kochiae 0%～20%, the Radix Rehmanniae 0%～20%.
2. a kind of treatment according to claim 1 is characterized in that the percentage by weight of the described raw material of Chinese medicine of this medicine is: Cortex Phellodendri 32%, Radix Sophorae Flavescentis 19%, Fructus Cnidii 11%, Rhizoma Atractylodis 11%, Flos Lonicerae 9%, Cortex Dictamni 6%, the Fructus Kochiae 6%, the Radix Rehmanniae 6% by various germ vulva prurituss, vaginitis, cervicitis, eczema scrotum, condyloma acuminatum and various fungus-caused dermopathic external used medicine.
3. medicine as claimed in claim 1 or 2 is characterized in that: it is lotion, suppository, spray, gel, vagina effervescence.
4. a kind of treatment as claimed in claim 1 is by various germ vulva prurituss, vaginitis, cervicitis, eczema scrotum, the preparation method of condyloma acuminatum and various fungus-caused dermopathic external used medicines, it is characterized in that this method is: get Cortex Phellodendri 15%～60%, Radix Sophorae Flavescentis 8%～40%, Fructus Cnidii 5%～25%, Rhizoma Atractylodis 5%～25%, Flos Lonicerae 5%～20%, Cortex Dictamni 0%～20%, the Fructus Kochiae 0%～20%, the Radix Rehmanniae 0%～20%, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate, relative density is 1.20～1.25 clear paste when being evaporated to 60 ℃, adding ethanol makes and contains alcohol amount and reach 60%～70%, left standstill 24 hours, filter, reclaim ethanol.
5. a kind of treatment as claimed in claim 4 is by various germ vulva prurituss, vaginitis, cervicitis, eczema scrotum, the preparation method of condyloma acuminatum and various fungus-caused dermopathic external used medicines, it is characterized in that this method is: get Cortex Phellodendri 32%, Radix Sophorae Flavescentis 19%, Fructus Cnidii 11%, Rhizoma Atractylodis 11%, Flos Lonicerae 9%, Cortex Dictamni 6%, the Fructus Kochiae 6%, the Radix Rehmanniae 6%, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate, relative density is 1.20～1.25 clear paste when being evaporated to 60 ℃, adding ethanol makes and contains alcohol amount and reach 60%～70%, left standstill 24 hours, and filtered, reclaim ethanol, add water to ormal weight, add benzoic acid, filter, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2007100291740A CN101347541B (en) | 2007-07-16 | 2007-07-16 | Medicament for treating gynecology disease and dermatopathy and preparation thereof |
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| CN2007100291740A CN101347541B (en) | 2007-07-16 | 2007-07-16 | Medicament for treating gynecology disease and dermatopathy and preparation thereof |
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| CN101347541A CN101347541A (en) | 2009-01-21 |
| CN101347541B true CN101347541B (en) | 2011-04-20 |
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Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101690785B (en) * | 2009-10-15 | 2011-12-21 | 贵州百灵企业集团制药股份有限公司 | Bacteriostatic lotion and preparation method thereof |
| CN101869626B (en) * | 2010-06-23 | 2012-05-23 | 南昌市男科医院 | Chinese medicinal compound preparation private care liquid, and preparation and application thereof |
| CN102274333A (en) * | 2011-08-22 | 2011-12-14 | 谢英华 | External washing Chinese medicine for treating vaginitis |
| CN103638229A (en) * | 2013-12-05 | 2014-03-19 | 青岛友铭辰生物技术有限公司 | Chinese medicinal lotion for treating eczema and preparation method thereof |
| CN104042794A (en) * | 2014-06-20 | 2014-09-17 | 成正德 | Liquid medicine for external use for gynecological inflammation |
| CN104815122A (en) * | 2015-04-23 | 2015-08-05 | 徐敏旌 | Traditional Chinese medicine for treating gynecologic inflammation |
| CN105770655A (en) * | 2016-04-24 | 2016-07-20 | 邹洪胜 | Traditional Chinese medicine composition for treating scroti eczema |
| CN105943982A (en) * | 2016-06-20 | 2016-09-21 | 郭嘉 | External antibacterial liquid for dermatoses |
| CN105998974A (en) * | 2016-06-28 | 2016-10-12 | 深圳市纯原上品文化传播有限公司 | Traditional Chinese medicine composition and gels for treating gynecologic inflammation and preparation method thereof |
| CN107789449A (en) * | 2016-08-30 | 2018-03-13 | 天津太平洋制药有限公司 | A kind of medicine for treating eczema and preparation method thereof |
| CN107375818A (en) * | 2017-09-01 | 2017-11-24 | 李贵荣 | A kind of medicine for treating condyloma acuminatum and preparation method thereof |
| CN108853705A (en) * | 2018-07-19 | 2018-11-23 | 内蒙古蒙菇农牧业科技有限公司 | It treats gynecological disease and inhibits the solid scrubbing agent of gynecological disease germ |
| CN110179887A (en) * | 2019-05-31 | 2019-08-30 | 张家界茶坤缘杜仲生物科技开发有限公司 | Treat dermopathic Chinese medicine composition and preparation method thereof |
| CN114306478B (en) * | 2020-09-29 | 2023-11-10 | 江西省儿童医院 | A Chinese medicinal composition for treating dermatoses |
| CN115779011A (en) * | 2021-09-10 | 2023-03-14 | 安徽华大医药科技有限公司 | Development of Chinese herbal medicine compound infantile eczema cream |
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