CN1068208C - Gynecological special-purpose tablet made from traditional Chinese medicine and its production method - Google Patents

Abstract

The present invention relates to a gynecologic special-purpose Chinese medicine effervescent tablet and a production method thereof. The Chinese medicine effervescent tablet is prepared from coptis root, bezoar, realgar, pearl, musk and indigo as main medicines, and medicines with the functions of promoting blood circulation for removing blood stasis and deodorizing and stopping leukorrhea are used as auxiliary medicines, and borneol is added; thus, all medicines can exert good effect. A diacolation process is used fro extracting the effective components of the Chinese herbal medicines, and the product of the present invention is obtained by the technical processes of crushing, pulverizing, mixing, tabletting, etc. The product of the present invention not only has good therapeutic effect on female edeitis, but also has good therapeutic effect of preventing and curing cancerization.

Description

Special-purpose Chinese medicine tablet of a kind of gynecological and production method thereof

The present invention relates to special-purpose Chinese medicine effervescent tablet of a kind of gynecological and production method thereof.

The female sex organs inflammation is one of common gynaecopathia, this class disease can betide any position of female sex organs, when sick, light then the local symptom general reaction different occur with degree, heavy then cause septicemia, even septic shock, but long-term chronic inflammatory disease cause cancer also, the medicine of therefore treating this type of disease is the problem that people pay close attention to always.At present, being used for the treatment of this sick medicine has Gu Eryin, FUYANKANG, hibitane suppository etc., but clinical practice proves that all there is some deficiency in these medicines, can not reach desirable therapeutic.As JIEERYIN cancer there is not preventive and therapeutic effect; FUYANKANG, hibitane suppository effective percentage are low, nor can give protection against cancer, and more do not have the effect of strengthening the body resistance.In addition, with fulgerize, Therapeutic Method such as freezing, laser all has certain shortcoming, can not effect a radical cure, cure the symptoms, not the disease.

The objective of the invention is at the prior art above shortcomings, the pathogenic principle all relevant with infection according to female sex organs inflammation, cancer, adopt the treatment mechanism of dampness pathogenic fire purging, removing the necrotic tissue and promoting granulation, strengthening the body resistance, removing obstruction for relieving pain, special-purpose Chinese medicine effervescent tablet of a kind of gynecological and production method thereof are provided.Medicine of the present invention is not only evident in efficacy to the female sex organs inflammation, and canceration is had excellent prevention and therapeutical effect, is treating both the principal and secondary aspects of a disease, control combination.

The object of the present invention is achieved like this: the special-purpose Chinese medicine effervescent tablet of a kind of gynecological; the principal agent that it is characterized in that this tablet comprises following composition: Rhizoma Coptidis, Calculus Bovis, Radix Et Rhizoma Rhei, Indigo Naturalis, Margarita, Fructus Ligustri Lucidi, Moschus, Realgar; the medicine that is aided with blood circulation promoting and blood stasis dispelling, deodorization leukorrhagia stopping; and the adding Borneolum Syntheticum, make all herbal medicines better bring into play drug effect

The medicine of blood circulation promoting and blood stasis dispelling, deodorization leukorrhagia stopping preferably includes Pulvis concha Mactrae, Radix Notoginseng, Sal Ammoniacus, Venenum Bufonis, Olibanum, Borax, Mirabilitum.

Wherein Rhizoma Coptidis can replace with Cortex Phellodendri, and Margarita can replace with Concha Margaritifera.Calculus Bovis can replace with the artificial Calculus Bovis.The pharmacological action of each medicine is: Rhizoma Coptidis, Calculus Bovis, the detoxifcation of Radix Et Rhizoma Rhei dampness, join the Indigo Naturalis clearing away heat-fire; Margarita, Borneolum Syntheticum, Pulvis concha Mactrae, Venenum Bufonis, Mirabilitum removing the necrotic tissue and promoting granulation; Rhizoma Coptidis, Realgar, Borax removing dampness and killing parasites; Moschus, Sal Ammoniacus, Olibanum, Realgar, Radix Notoginseng removing obstruction for relieving pain, blood circulation promoting and blood stasis dispelling; Fructus Ligustri Lucidi, Margarita, Radix Notoginseng strengthening vital QI to eliminate pathogenic factors.

The present invention is applicable to that the pyretic toxicity or the turbid damp pathogen stasis of blood stagnate, and influences QI-blood circulation, causes coagulation of QI-blood, dashes and appoint impaired and gynaecopathia that cause, as diseases such as vulvitis, vaginitis, cervicitis, cervical cancers.

Concrete proportioning of the present invention consists of and (is as the criterion unit to prepare 1000 gram medicines: gram): Rhizoma Coptidis 1000～1500; Radix Et Rhizoma Rhei: 500～1000; Artificial Calculus Bovis: 100～150; Moschus: 0.5～3; Realgar: 10～20; Borneolum Syntheticum: 30～50; Margarita: 100～150; Indigo Naturalis: 100～300; Fructus Ligustri Lucidi: 500～1000.

The concrete consumption of the medicine of blood circulation promoting and blood stasis dispelling, deodorization leukorrhagia stopping is (a unit: gram): Radix Notoginseng: 100～300; Pulvis concha Mactrae: 100～200; Olibanum: 50～100; Borax: 100～150; Venenum Bufonis: 0.5～1.5; Mirabilitum: 75～150; Semen Strychni (processed): 1～5; Sal Ammoniacus: 100～200

Wherein, the content height of Rhizoma Coptidis, good drug efficacy, but should meet the consumption that pharmacopeia is stipulated as far as possible; The Radix Et Rhizoma Rhei consumption is too high, may cause that the patient suffers from diarrhoea, and consumption is low excessively, affects the treatment, so preferably consumption is controlled between 500～1000 grams; Calculus Bovis, Moschus, Margarita, Radix Notoginseng consumption height increase cost, and consumption is crossed to hang down and then missed one's aim; Realgar is owing to itself have certain toxicity, so the consumption height will increase the toxicity of medicine of the present invention, but consumption crosses when low, do not reach due effect, therefore, with its consumption be controlled at 10～20 restrain between; Borneolum Syntheticum is as the concordant remedies that the medicine of respectively distinguishing the flavor of can be played a role better, and consumption guarantees that it can play effect and get final product, Semen Strychni (processed) consumption height, and the toxicity of increase product, therefore, its consumption should be controlled at below 5 grams.

Another object of the present invention is achieved in that the production method of the special-purpose Chinese medicine effervescent tablet of a kind of gynecological, comprises following technical process:

1. the medical herbs of respectively distinguishing the flavor of of aequum is cleaned, dry, be ground into coarse granule, adopt 70% ethanol to extract wherein active ingredient with percolation;

2. with behind the said extracted thing recovered alcohol, be condensed into extractum;

3. Radix Notoginseng, Realgar, Indigo Naturalis, Pulvis concha Mactrae, Olibanum, Borax, Mirabilitum, Sal Ammoniacus, Semen Strychni (processed) are pulverized, and crossed sieve No. seven;

4. Moschus, Venenum Bufonis, artificial Calculus Bovis, Borneolum Syntheticum, Margarita powder are ground altogether, and cross sieve No. seven;

5. with 2,3 technical process gains mixing granulations, drying, with being not more than 16 purposes sieve granulate;

6. with after 4, the 5 technical process gained medicament mixed, add citric acid: 25～35 grams, Su Da: 20～30 grams, magnesium stearate: 20～70 grams, use the V-Mixer mixing;

7. make olive-shaped tablet with special-shaped tablet machine, every heavy 1 gram promptly gets product of the present invention

Product of the present invention is a medicine for external use, and using method is: after tablet was placed patient's vagina deep, tablet is disintegrate voluntarily.

The medicine that product of the present invention is identical with exercise use is compared and is had the following advantages: 1. according to clinical verification, gynecological inflammation, canceration are because due to wet, the heat, worm, corruption, void, cunning substantially, the present invention is with the pathogenic fire purging of Rhizoma Coptidis dampness, with Radix Et Rhizoma Rhei, Indigo Naturalis heat-clearing and toxic substances removing, with Realgar, Borax parasite killing, with putrefaction-removing granulation-promotings such as Margarita, Borneolum Syntheticums, set upright with tonify deficiency such as Fructus Ligustri Lucidi, Radix Notoginseng, improve immunity, turbid with Moschus, Borneolum Syntheticum causing resuscitation with aromatic drugs, the lucid yang sending upization, each medicine compatibility is proper, can reach treating both the principal and secondary aspects of a disease, uncharms and consolidate bonded purpose; 2. discard the dross and select the essential, elaborate: Chinese herbal medicine is extracted through science, select the essence, through science compatibility processing and fabricating, make its raising evident in efficacy, changed Chinese medicine decocting, ball, loose, cream, pellet form, be refined into vaginal effervescent tablet, local application, tablet is voluntarily after the disintegrate, can fit tightly with vagina, cervix uteri, guarantee curative effect, concentration improves, and avoids malabsorption, digestive tract to destroy and the liver first-pass effect again, reduce toxicity, safe and reliable; 3. experiment showed, that medicine of the present invention is not only evident in efficacy to gynecological inflammation, and remarkable to preventing and treating the malignant change effect, be applicable to morbidity just, in, late period.

Below in conjunction with specific embodiment in detail the present invention is described in detail

The special-purpose Chinese medicinal tablet of a kind of gynecological, its principal agent is selected following each component for use: Rhizoma Coptidis, Radix Et Rhizoma Rhei, Fructus Ligustri Lucidi, Realgar, artificial Calculus Bovis, Margarita, Moschus, Indigo Naturalis, Borneolum Syntheticum have heat clearing and damp drying, strengthening the body resistance function; The choice of drug of blood circulation promoting and blood stasis dispelling, deodorization leukorrhagia stopping: Radix Notoginseng, Pulvis concha Mactrae, Sal Ammoniacus, Venenum Bufonis, Olibanum, Borax, Mirabilitum, Semen Strychni (processed), other adds Radix Sanguisorbae, the hemostasis leukorrhagia stopping.

The concrete consumption of above-mentioned each component is (being as the criterion unit to prepare 1000 grams medicine of the present invention: restrain):

Rhizoma Coptidis: 1200; Radix Et Rhizoma Rhei: 1000; Indigo Naturalis: 100;

Artificial Calculus Bovis: 40; Radix Notoginseng: 80; Olibanum: 60;

Margarita: 50; Moschus: 3; Borax: 100;

Pulvis concha Mactrae: 100; Fructus Ligustri Lucidi: 800; Radix Sanguisorbae: 800;

Sal Ammoniacus: 80; Realgar: 20; Mirabilitum: 120;

Venenum Bufonis: 1; Borneolum Syntheticum: 30; Semen Strychni (processed): 3.

Concrete preparation process is as follows:

1. with after the Rhizoma Coptidis of aequum, Radix Et Rhizoma Rhei, Fructus Ligustri Lucidi, the Radix Sanguisorbae cleaning, drying, be ground into the coarse granule shape, use 70% ethanol then, adopt percolation to extract wherein elite;

2. be condensed into extractum with said extracted thing recovered alcohol and with it;

3. Indigo Naturalis, Pulvis concha Mactrae, Radix Notoginseng, Olibanum, Borax, Mirabilitum, Sal Ammoniacus, Realgar, Semen Strychni (processed) are pulverized, and crossed sieve No. seven;

4. Moschus, Venenum Bufonis, artificial Calculus Bovis, Borneolum Syntheticum, Margarita powder are ground altogether, and cross sieve No. seven;

5. 2,3 technical process gained medicament mixed are granulated, drying is crossed 16 mesh sieve granulate;

6. with 4,5 technical process gained medicament mixed, add citric acid: 30 grams, Su Da: 25 grams, magnesium stearate: 25 grams, use the V-Mixer mixing;

7. make olive-shaped tablet with special-shaped tablet machine, every heavy 1 gram promptly gets product of the present invention.

Product of the present invention is pale brown color chips agent, fragrant odour, and bitter in the mouth, cool in nature shows through stability experiment: product of the present invention is after aluminum platinum packing, and room temperature was placed 24 months down, detects in conjunction with meeting quality standard.

The using method of product of the present invention is: tablet is sent into the vagina deep, and once-a-day, seven days is a course of treatment.

Product of the present invention is through state specialized detection unit: Hebei Medical University's pharmacology department, clinical research institute of China-Japan Friendship Hospital examining report are as follows: product cooling bath 1.65 of the present invention and 3.3mg/ sheet all have antibacterial action to staphylococcus aureus, Staphylococcus albus and Ke Leishi bacillus; Fungus (Candida albicans) is particularly responsive to product of the present invention.Product hot dipping liquid of the present invention can improve antibacterial action, and the 3.3mg/ sheet can suppress escherichia coli, the 0.1mg/ sheet can suppress Klebsiella pneumoniae, can improve the inhibitory action to fungus.

Product 60% ointment of the present invention can have tangible itching-relieving action obviously to anti-inflammatory swelling, significantly shortens the bleeding time, has anastalsis, does not have irritated phenomenon.

Mice is 5g/kg to the maximum tolerated dose of product of the present invention, is equivalent to 250 times of human dosage, belongs to nontoxic.

Claims (4)

1, the special-purpose Chinese medicine effervescent tablet of a kind of gynecological is characterized in that the concrete proportioning of this medicine is, is as the criterion unit to prepare 1000 gram tablets: gram:

Rhizoma Coptidis: 1000-1500 Calculus Bovis: 100-150

Radix Et Rhizoma Rhei: 500-1000 Indigo Naturalis: 100-300

Margarita: 100-150 Moschus: 0.5-3

Realgar: 10-20 Pulvis concha Mactrae: 100-200

Radix Notoginseng: 100-300 Fructus Ligustri Lucidi: 500-1000

Sal Ammoniacus: 100-200 Venenum Bufonis: 0.5-1.5

Olibanum: 50-100 Borax: 100-150

Mirabilitum: 75-150 Semen Strychni (processed): 1-5.

2, by the special-purpose Chinese medicine effervescent tablet of the described gynecological of claim 1, it is characterized in that Rhizoma Coptidis can replace with Cortex Phellodendri, Margarita can replace with Concha Margaritifera, and Calculus Bovis can replace with the artificial Calculus Bovis.

3, the special-purpose Chinese medicine effervescent tablet of a kind of gynecological is characterized in that the composition proportioning of this medicine is, is as the criterion unit to prepare 1000 gram tablets: gram:

Rhizoma Coptidis: 1200 Radix Et Rhizoma Rhei: 1000 Indigo Naturaliss: 100

Artificial Calculus Bovis: 40 Radix Notoginseng: 80 Olibanums: 60

Margarita: 50 Moschus: 3 Boraxs: 100

Pulvis concha Mactrae: 100 Fructus Ligustri Lucidi: 800 Radix Sanguisorbaes: 800

Sal Ammoniacus: 80 Realgars: 20 Mirabilitums: 120

Venenum Bufonis: 1 Borneolum Syntheticum: 30 Semen Strychni (processed)s: 3.

4, the production method of the special-purpose Chinese medicine effervescent tablet of gynecological as claimed in claim 1 is characterized in that this production method comprises following technical process:

1. the medical herbs of respectively distinguishing the flavor of with aequum adopts percolation to extract wherein active ingredient with 70% ethanol;

2. the said extracted thing is reclaimed and spill smart back and be condensed into extractum;

3. Radix Notoginseng, Realgar, Indigo Naturalis, Pulvis concha Mactrae, Olibanum, Borax, Mirabilitum, Semen Strychni (processed), the Sal Ammoniacus of aequum are pulverized and cross sieve No. seven;

4. Moschus, Venenum Bufonis, artificial Calculus Bovis, Borneolum Syntheticum, the Margarita of aequum are ground altogether, and cross sieve No. seven;

5. will be 2., 3. technical process gains mixing granulation, drying, with being not more than 16 mesh sieve granulate;

6. will be 4., 5. technical process gained medicament mixed, add citric acid 25-35 gram, Su Da 20-30 gram, magnesium stearate 10-30 gram, and use the V-Mixer mixing;

1. make olive-shaped tablet with special-shaped tablet machine, every heavy 1 gram promptly gets product of the present invention.