CN112316050A - Antibacterial nursing lotion and application thereof - Google Patents

Antibacterial nursing lotion and application thereof Download PDF

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Publication number
CN112316050A
CN112316050A CN202011239914.5A CN202011239914A CN112316050A CN 112316050 A CN112316050 A CN 112316050A CN 202011239914 A CN202011239914 A CN 202011239914A CN 112316050 A CN112316050 A CN 112316050A
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parts
essential oil
extract
root extract
ceramide type
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邱志国
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Hangzhou Hongguo Technology Co ltd
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Hangzhou Hongguo Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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Abstract

The invention relates to the technical field of bacteriostatic lotion. The invention provides an antibacterial nursing lotion and application thereof, wherein the antibacterial nursing lotion comprises the following components: 10-20 parts of sophora flavescens root extract, 10-20 parts of fructus cnidii extract, 5-15 parts of rheum palmatum root extract, 5-15 parts of dandelion root extract, 4-12 parts of scutellaria baicalensis root extract, 2-8 parts of licorice root extract, 1-5 parts of honeysuckle flower extract, 3-5 parts of ceramide type 1, 3-7 parts of ceramide type 3, 5-15 parts of alpha-glucan oligosaccharide, 10-20 parts of panthenol and 0.1-0.14 part of plant essential oil. The main raw materials adopted by the bacteriostatic liquid are extracts of traditional Chinese medicine raw materials, and the bacteriostatic liquid is wide in source and low in cost. Meanwhile, the formula is reasonable, the effect is obvious, staphylococcus aureus, escherichia coli and candida albicans can be effectively inhibited, and the traditional Chinese medicine is safe, free of irritation and free of side effects.

Description

Antibacterial nursing lotion and application thereof
Technical Field
The invention relates to the technical field of antibacterial washing liquid, and particularly relates to antibacterial nursing washing liquid and application thereof.
Background
The existing lotion mainly comprises western medicine components, and the western medicine lotion can achieve the purpose of sterilization and disinfection by eliminating pathogenic microorganisms in the environment. The bactericidal composition is represented by metronidazole, chlorhexidine and the like, has strong bactericidal capability, but has certain irritation, can generate irritation influence, is easy to damage the pH environment, has the feeling of skin dryness and discomfort after use, and sometimes even causes severe allergy. Meanwhile, because of long-term and large-scale use of antibiotics, the medicament is easy to form stubborn drug resistance for human, and the curative effect of the medicament for reuse is greatly reduced.
Although the commonly used western medicine lotion has quick response, the lotion obviously treats the symptoms and does not treat the root causes. The traditional Chinese medicine components can condition themselves and treat for a long time, and although the effect is slow, the treatment effect is very effective and the side effect is small.
Disclosure of Invention
The invention aims to provide an antibacterial nursing lotion and application thereof, which can condition the body, and has effective and lasting treatment effect and small side effect.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides an antibacterial nursing lotion, which comprises the following components: radix Sophorae Flavescentis extract, fructus Cnidii extract, radix et rhizoma Rhei Palmati extract, herba Taraxaci extract, Scutellariae radix extract, Glycyrrhrizae radix extract, flos Lonicerae extract, ceramide type 1, ceramide type 3, alpha-glucan oligosaccharide, panthenol and plant essential oil.
Preferably, the composition comprises the following components in parts by weight: 10-20 parts of sophora flavescens root extract, 10-20 parts of fructus cnidii extract, 5-15 parts of rheum palmatum root extract, 5-15 parts of dandelion root extract, 4-12 parts of scutellaria baicalensis root extract, 2-8 parts of licorice root extract, 1-5 parts of honeysuckle flower extract, 3-5 parts of ceramide type 1, 3-7 parts of ceramide type 3, 5-15 parts of alpha-glucan oligosaccharide, 10-20 parts of panthenol and 0.1-0.14 part of plant essential oil.
Preferably, the composition comprises the following components in parts by weight: 15 parts of sophora flavescens root extract, 15 parts of fructus cnidii extract, 10 parts of rheum palmatum root extract, 10 parts of dandelion root extract, 8 parts of scutellaria baicalensis root extract, 5 parts of licorice root extract, 3 parts of honeysuckle flower extract, 4 parts of ceramide type 1, 5 parts of ceramide type 3, 10 parts of alpha-glucan oligosaccharide, 14.88 parts of panthenol and 0.12 part of plant essential oil.
Preferably, the plant essential oil is one or more of rose essential oil, lily essential oil, lavender essential oil, chamomile essential oil and tea tree essential oil.
Preferably, the plant essential oil comprises rose essential oil, lily essential oil, lavender essential oil, chamomile essential oil and tea tree essential oil in a mass ratio of 4-6: 2-4: 1-3: 0.5-1.5: 0.5 to 1.5.
Preferably, the plant essential oil comprises rose essential oil, lily essential oil, lavender essential oil, chamomile essential oil and tea tree essential oil in a mass ratio of 5: 3: 2: 1: 1.
the invention also provides application of the antibacterial nursing lotion in inhibiting staphylococcus aureus, escherichia coli and candida albicans.
The invention provides an antibacterial nursing lotion and application thereof, wherein the antibacterial nursing lotion comprises the following components: 10-20 parts of sophora flavescens root extract, 10-20 parts of fructus cnidii extract, 5-15 parts of rheum palmatum root extract, 5-15 parts of dandelion root extract, 4-12 parts of scutellaria baicalensis root extract, 2-8 parts of licorice root extract, 1-5 parts of honeysuckle flower extract, 3-5 parts of ceramide type 1, 3-7 parts of ceramide type 3, 5-15 parts of alpha-glucan oligosaccharide, 10-20 parts of panthenol and 0.1-0.14 part of plant essential oil. The main raw materials adopted by the bacteriostatic liquid are extracts of traditional Chinese medicine raw materials, and the bacteriostatic liquid is wide in source and low in cost. Meanwhile, the formula is reasonable, the effect is obvious, staphylococcus aureus, escherichia coli and candida albicans can be effectively inhibited, and the traditional Chinese medicine is safe, free of irritation and free of side effects.
Detailed Description
The invention provides an antibacterial nursing lotion, which comprises the following components: radix Sophorae Flavescentis extract, fructus Cnidii extract, radix et rhizoma Rhei Palmati extract, herba Taraxaci extract, Scutellariae radix extract, Glycyrrhrizae radix extract, flos Lonicerae extract, ceramide type 1, ceramide type 3, alpha-glucan oligosaccharide, panthenol and plant essential oil.
In the invention, the composition comprises the following components in parts by weight: 10-20 parts of sophora flavescens root extract, 10-20 parts of fructus cnidii extract, 5-15 parts of rheum palmatum root extract, 5-15 parts of dandelion root extract, 4-12 parts of scutellaria baicalensis root extract, 2-8 parts of licorice root extract, 1-5 parts of honeysuckle flower extract, 3-5 parts of ceramide type 1, 3-7 parts of ceramide type 3, 5-15 parts of alpha-glucan oligosaccharide, 10-20 parts of panthenol and 0.1-0.14 part of plant essential oil.
In the invention, the preferred radix sophorae flavescentis extract is 12-18 parts, and the further preferred is 15 parts.
In the present invention, the cnidium monnieri fruit extract is preferably 12 to 18 parts, and more preferably 15 parts.
In the invention, the rhubarb root extract is preferably 7-13 parts, and more preferably 10 parts.
In the present invention, the Taraxacum officinale root extract is preferably 7 to 13 parts, and more preferably 10 parts.
In the present invention, the scutellaria root extract is preferably 6 to 10 parts, and more preferably 8 parts.
In the invention, the licorice root extract is preferably 4-6 parts, and more preferably 5 parts.
In the invention, the honeysuckle flower extract is preferably 2-4 parts, and more preferably 3 parts.
In the present invention, the ceramide type 1 is preferably 4 parts.
In the present invention, the ceramide type 3 is preferably 5 parts.
In the present invention, the α -glucan oligosaccharide is preferably 7 to 13 parts, and more preferably 10 parts.
In the present invention, the panthenol is preferably 12 to 18 parts, and more preferably 14.88 parts.
In the present invention, the plant essential oil is preferably 0.11 to 0.13 part, and more preferably 0.12 part.
In the present invention, the plant essential oil is preferably one or more of rose essential oil, lily essential oil, lavender essential oil, chamomile essential oil, and tea tree essential oil.
In the invention, the mass ratio of the rose essential oil, the lily essential oil, the lavender essential oil, the chamomile essential oil and the tea tree essential oil in the plant essential oil is preferably 4-6: 2-4: 1-3: 0.5-1.5: 0.5 to 1.5, and more preferably 5: 3: 2: 1: 1.
the invention also provides application of the antibacterial nursing lotion in inhibiting staphylococcus aureus, escherichia coli and candida albicans.
The bacteriostatic care lotion provided by the invention is explained in detail by the following examples, but the bacteriostatic care lotion cannot be understood as limiting the protection scope of the invention.
Example 1
The bacteriostatic nursing lotion is prepared from the following raw materials in parts by weight: 10 parts of sophora flavescens root extract, 20 parts of fructus cnidii extract, 5 parts of rheum palmatum root extract, 15 parts of dandelion root extract, 4 parts of scutellaria baicalensis root extract, 2 parts of licorice root extract, 1 part of honeysuckle flower extract, 5 parts of ceramide type 1, 3 parts of ceramide type 3, 15 parts of alpha-glucan oligosaccharide, 10 parts of panthenol, 0.04 part of rose essential oil, 0.04 part of lily essential oil, 0.03 part of lavender essential oil, 0.005 part of chamomile essential oil and 0.005 part of tea tree essential oil.
Example 2
The bacteriostatic nursing lotion is prepared from the following raw materials in parts by weight: 15 parts of sophora flavescens root extract, 15 parts of fructus cnidii extract, 10 parts of rheum palmatum root extract, 10 parts of dandelion root extract, 8 parts of scutellaria baicalensis root extract, 5 parts of licorice root extract, 3 parts of honeysuckle flower extract, 4 parts of ceramide type 1, 5 parts of ceramide type 3, 10 parts of alpha-glucan oligosaccharide, 14.88 parts of panthenol, 0.05 part of rose essential oil, 0.03 part of lily essential oil, 0.02 part of lavender essential oil, 0.01 part of chamomile essential oil and 0.01 part of tea tree essential oil.
Example 3
The bacteriostatic nursing lotion is prepared from the following raw materials in parts by weight: 20 parts of sophora flavescens root extract, 10 parts of fructus cnidii extract, 15 parts of rheum palmatum root extract, 5 parts of dandelion root extract, 12 parts of scutellaria baicalensis root extract, 8 parts of licorice root extract, 5 parts of honeysuckle flower extract, 3 parts of ceramide type 1, 7 parts of ceramide type 3, 5 parts of alpha-glucan oligosaccharide, 20 parts of panthenol, 0.06 part of rose essential oil, 0.02 part of lily essential oil, 0.01 part of lavender essential oil, 0.015 part of chamomile essential oil and 0.015 part of tea tree essential oil.
Examples of the experiments
Test strains: staphylococcus aureus, Escherichia coli and Candida albicans, resuscitated before testing, and made into 1 × 109cfu/mL of bacterial liquid.
Culture medium: MH agar medium.
Manufacturing a blank MH flat plate: 10mL of sterile MH agar medium was added to the plate and cooled to prepare a blank MH agar plate.
Preparation of the drug-containing agar plate: 1mL of the bacteriostatic care lotion prepared in example 1 and 9mL of sterile MH agar medium were added to the plate, mixed well, and cooled to prepare a drug-containing agar plate. Drug-containing plates of example 2 and example 3 were prepared in the same manner.
In the same manner, staphylococcus aureus, escherichia coli and candida albicans solutions were inoculated into each of the drug-containing plates and blank plates of examples 1-3, respectively, and each plate was inoculated with 0.1mL of the bacteria solution, and the procedure was repeated three times. The blank plate is used as a reference, and the inoculated strains and the contained medicines are marked on the inoculated plate. The results of each group were observed after incubation at 37 ℃ for 24 h.
The experimental results are as follows: the colony numbers of the three bacteria in the control group are obviously higher than those of all experimental groups, and the antibacterial nursing lotion in the examples 1-3 can effectively inhibit staphylococcus aureus, escherichia coli and candida albicans. The bacteriostatic care lotion prepared in the example 2 has the most excellent effect, the inhibition rate on staphylococcus aureus reaches 98.1%, the inhibition rate on escherichia coli reaches 97.0%, and the inhibition rate on candida albicans reaches 93.9%; the bacteriostat prepared in the embodiment 1 has the advantages that the bacteriostat can reach 90.2 percent of the inhibition rate to staphylococcus aureus, 95.6 percent of the inhibition rate to escherichia coli and 94.1 percent of the inhibition rate to candida albicans; the bacteriostat prepared in the embodiment 3 has the inhibition rate of 92.6 percent on staphylococcus aureus, 93.7 percent on escherichia coli and 91.0 percent on candida albicans.
From the above embodiments, the invention provides an antibacterial care lotion and an application thereof, wherein the antibacterial care lotion comprises the following components: 10-20 parts of sophora flavescens root extract, 10-20 parts of fructus cnidii extract, 5-15 parts of rheum palmatum root extract, 5-15 parts of dandelion root extract, 4-12 parts of scutellaria baicalensis root extract, 2-8 parts of licorice root extract, 1-5 parts of honeysuckle flower extract, 3-5 parts of ceramide type 1, 3-7 parts of ceramide type 3, 5-15 parts of alpha-glucan oligosaccharide, 10-20 parts of panthenol and 0.1-0.14 part of plant essential oil. The main raw materials adopted by the bacteriostatic liquid are extracts of traditional Chinese medicine raw materials, and the bacteriostatic liquid is wide in source and low in cost. Meanwhile, the formula is reasonable, the effect is obvious, staphylococcus aureus, escherichia coli and candida albicans can be effectively inhibited, and the traditional Chinese medicine is safe, free of irritation and free of side effects.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (7)

1. An antibacterial nursing lotion is characterized by comprising the following components: radix Sophorae Flavescentis extract, fructus Cnidii extract, radix et rhizoma Rhei Palmati extract, herba Taraxaci extract, Scutellariae radix extract, Glycyrrhrizae radix extract, flos Lonicerae extract, ceramide type 1, ceramide type 3, alpha-glucan oligosaccharide, panthenol and plant essential oil.
2. The bacteriostatic care lotion according to claim 1, which is characterized by comprising the following components in parts by weight: 10-20 parts of sophora flavescens root extract, 10-20 parts of fructus cnidii extract, 5-15 parts of rheum palmatum root extract, 5-15 parts of dandelion root extract, 4-12 parts of scutellaria baicalensis root extract, 2-8 parts of licorice root extract, 1-5 parts of honeysuckle flower extract, 3-5 parts of ceramide type 1, 3-7 parts of ceramide type 3, 5-15 parts of alpha-glucan oligosaccharide, 10-20 parts of panthenol and 0.1-0.14 part of plant essential oil.
3. An antibacterial care lotion according to claim 2, characterized by comprising the following components in parts by weight: 15 parts of sophora flavescens root extract, 15 parts of fructus cnidii extract, 10 parts of rheum palmatum root extract, 10 parts of dandelion root extract, 8 parts of scutellaria baicalensis root extract, 5 parts of licorice root extract, 3 parts of honeysuckle flower extract, 4 parts of ceramide type 1, 5 parts of ceramide type 3, 10 parts of alpha-glucan oligosaccharide, 14.88 parts of panthenol and 0.12 part of plant essential oil.
4. An antibacterial care lotion according to any one of claims 1 to 3, wherein the plant essential oil is one or more of rose essential oil, lily essential oil, lavender essential oil, chamomile essential oil and tea tree essential oil.
5. An antibacterial nursing lotion according to claim 4, wherein the plant essential oil comprises 4-6 mass parts of rose essential oil, lily essential oil, lavender essential oil, chamomile essential oil and tea tree essential oil: 2-4: 1-3: 0.5-1.5: 0.5 to 1.5.
6. An antibacterial nursing lotion according to claim 5, wherein the plant essential oil comprises rose essential oil, lily essential oil, lavender essential oil, chamomile essential oil and tea tree essential oil in a mass ratio of 5: 3: 2: 1: 1.
7. use of the bacteriostatic care lotion according to any one of claims 1 to 6 for inhibiting staphylococcus aureus, escherichia coli and candida albicans.
CN202011239914.5A 2020-11-09 2020-11-09 Antibacterial nursing lotion and application thereof Pending CN112316050A (en)

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Application publication date: 20210205