CN109646712A - A kind of sulikol liquid dressing and preparation method thereof - Google Patents
A kind of sulikol liquid dressing and preparation method thereof Download PDFInfo
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- CN109646712A CN109646712A CN201811599050.0A CN201811599050A CN109646712A CN 109646712 A CN109646712 A CN 109646712A CN 201811599050 A CN201811599050 A CN 201811599050A CN 109646712 A CN109646712 A CN 109646712A
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The present invention relates to pharmaceutical technology field, a kind of sulikol liquid dressing and preparation method thereof is provided.The present invention solves the problems, such as that sulphur is insoluble in water using sulikol, rhubarb total anthraquinone, ultra-low molecular hyaluronic acid, ceramide, Lavender and silicone as principle active component；The volatility and easily oxidizable for reducing sulphur avoid the shortcomings that the smell is awful and pollution clothes when sulphur directly uses；It eliminates sulphur and skin directly largely contacts the adverse reaction of generation.There is the present invention desinsection, sterilization, antipruritic, promotion wound healing, inhibition scar to be formed; the advantages that repairing and protecting skin, especially suitable for acne, the treatment of brandy nose, skin toxoplasmosis, trichomonas pruritus vulvue, tinea of feet and hands, onychomycosis, sweat stain, psoriasis, favus of the scalp, seborrhea, neurodermatitis.The preparation method of sulikol liquid dressing disclosed in this invention is formulated science, and preparation process is simple, easy to use, can be used for industrialized production.
Description
Technical field
The invention belongs to pharmaceutical technology fields, are related to a kind of liquid dressing, in particular to a kind of sulikol liquid dressing and
Preparation method.
Background technique
Skin packet accounts for about the 16% of body weight on human body surface, with the external world direct environment contact, have protection,
The functions such as feeling, secretion, excretion, breathing.Skin is the maximum organ of human body, because the kinds of Diseases caused by skin lesion are numerous
More, the cause of disease is complicated.Wherein with mechanical skin damage (such as wound) and biological skin injury (such as helminth or microorganism sense
Dye) caused by skin disease it is most commonly seen.
Currently, in the medicament of skin disease caused by market treatment helminth and microorganism, based on emulsion or paste,
Cardinal principle is skin disease caused by addition silver ion, sulphur, antibiotic or other treatment helminth and microorganism in a medicament
The medicament of disease has preferable therapeutic effect.But these medicaments are in the form of emulsion or paste and skin contact, absorbability compared with
Difference, needing to smear the long period can just fully absorb, and have greasy feeling on skin after smearing, and use for a long time can block hair
Hole, cutaneous breathing；It is excessive that local skin drug concentration is also resulted in when in use with emulsion or paste, causes other not
Good reaction.
Liquid dressing is to be used to debridement, flushing, wet acute and chronic wounds, ulcer, notch, scratch and burn in medical industry
Solution, in liquid form with skin contact, human body be easy absorb, tell on rapidly, and for a long time use will not generate
Side effect can be big if the medicament for treating skin disease caused by helminth and microorganism can be made into the form of liquid dressing
The big using effect and the scope of application for promoting medicament.Current existing liquid dressing mainly concentrates the treatment of minor trauma, such as " one
Kind liquid dressing and preparation method thereof " (CN201711214230) and " full-service fluid dressing and preparation method thereof "
(CN201610553348) etc., main function is reached by protection wound climate, promotion wound healing, prevention wound infection
To therapeutic purposes, and there is no therapeutic effect for skin disease caused by helminth and microorganism." one kind is for treating skin for patent
External use liquid dressing of skin disease and preparation method thereof and application method " (CN201810819756), which discloses, a kind of treats ox
The liquid dressing of psoriasis, raw material is simple with method, but mechanism and side effect and unintelligible, can not be used for helminth and microorganism
The treatment of the skin diseases of infection.Also, skin disease caused by helminth and microorganism is often with a variety of symptoms, such as skin
Rash, itch, wound, scar etc., this is not that aforesaid liquid dressing can solve.
Liquid dressing can not solve skin disease caused by helminth and microorganism main the reasons are as follows at present:
1, the medicament for treating skin disease caused by helminth and microorganism is insoluble in water mostly, and water can not become the solution of medicament, because
The medicament of skin disease caused by this treatment helminth and microorganism can only be made into emulsion or paste；Even if 2, a small number of treatments are parasitic
The medicament of skin disease caused by worm and microorganism is water-soluble to be made into solution, and pharmacological property pharmacological property when touching skin is best,
It will soon work, but duration is poor, can not keep effect for a long time；3, skin disease caused by helminth and microorganism is treated
After the medicament of disease is dissolved in water, medicament can be in direct contact with the skin when in use, if a large amount of contacts will lead to skin generation for a long time
Adverse reaction.
Summary of the invention
It is an object of the invention to be directed to the above-mentioned problems in the prior art, medicament is avoided to there is inconvenience in use
And adverse reaction, it provides dedicated for a kind of sulikol liquid dressing of skin disease caused by treatment helminth and microorganism.
Object of the invention can be realized by the following technical scheme: a kind of sulikol liquid dressing, according to parts by weight,
Including following components:
0.5~15 part of sulikol；
0.5~5 part of rhubarb total anthraquinone；
39.5~84.9 parts of water；
The sulikol is the drusen that sulphur and Arabic gum are prepared into, and the Arabic gum is coated on sulphur shape
At microcapsules, the microcapsules can be uniformly distributed in water, form colloidal solution.
The working principle of the invention: a kind of sulikol liquid dressing of the present invention substitutes sulphur solution using sulikol
The problem of sulphur of having determined is insoluble in water；The protection of Arabic gum forms the slow-releasing system of sulikol, enables sulikol for a long time
Keep effect；And Arabic gum has film forming, can form layer protecting film in skin surface, it is straight with skin to eliminate sulphur
It connects the adverse reactions that a large amount of contacts generate, prevents external microbe from entering to invade the injury of harmful substance.
Preferably, a kind of sulikol liquid dressing, according to parts by weight, including following components:
0.5~10 part of sulikol；
1~5 part of rhubarb total anthraquinone；
49.5~80.4 parts of water.
Preferably, the sulphur is nanoscale sulphur, sulikol is that nanoscale sulphur is received with what Arabic gum was prepared into
Rice drusen, the Arabic gum are coated on outside nanoscale sulphur and form microcapsules, and the microcapsules can uniformly divide in water
Cloth forms colloidal solution.
Preferably, the mass ratio of sulphur and Arabic gum is 1:2~5 in the sulikol.
Preferably, the sulikol is I of 75% nanoscale sulphur and 25% United States Pharmacopeia rank (USP rank)
The nano sulfur particle that primary glue is prepared into.
Preferably, the weight ratio of the sulikol and rhubarb total anthraquinone is 8~12:1.
Preferably, the preparation method of the rhubarb total anthraquinone the following steps are included:
S1, rhubarb medicinal material is crushed, is sieved；
S2, calcium hydroxide are added to the water dissolution, take supernatant spare；
S3, rhubarb medicinal material powder is extracted using calcium hydroxide supernatant；
S4, it is filtered, ultrafiltration is carried out after the completion of filtering；
S5, pH is adjusted to 2~4 using acidic materials, precipitating, filtering precipitates；The pH is the acid according to rhubarb total anthraquinone
Property is come what is determined, and when pH is less than 2, anthraquinones unstable chemcial property is not easy to extract；It, can not be by anthracene when pH is greater than 4
Quinones substance all precipitates, and recovery rate is caused to reduce；
S6, the pellet frozen in step S5 is dried, obtains rhubarb total anthraquinone.
Preferably, in the step S3, using ultrasonic wave assisted extraction, rhubarb medicinal material powder and calcium hydroxide supernatant
Mass ratio be 1:3~10, the mass ratio is determined according to the volume size of medicinal material, rheum officinale medicinal part be root, hydrogen
After the volume of calcium oxide supernatant is not to cross rheum officinale, the calcium hydroxide supernatant for adding 5~20% (volume ratios) is preferred.
Preferably, being not less than 80% using the rhubarb total anthraquinone purity of above method preparation.
Preferably, the sulikol liquid dressing further includes following components:
Preferably, the sulikol liquid dressing further includes following components:
Preferably, the molecular weight of the ultra-low molecular hyaluronic acid is 3000~10000.
Preferably, the sulikol liquid dressing, skin disease caused by specifically treating because of helminth and microorganism is special
Not Shi Yongyu acne, brandy nose, skin toxoplasmosis, trichomonas pruritus vulvue, tinea of feet and hands, onychomycosis, sweat stain, psoriasis, favus of the scalp,
The treatment of seborrhea, neurodermatitis.
Preferably, the method for administration of the sulikol liquid dressing is spray, liniment, lotion, ballpoint agent, patch
Agent.
A kind of preparation method of sulikol liquid dressing, comprising the following steps:
P1, weigh sulikol, rhubarb total anthraquinone is added to the water, ultrasonic wave dissolution, obtain solution a；
P2, weigh ultra-low molecular Sodium Hyaluronate, after ceramide is added to the water dissolution, add polyhexamethylene guanide,
Tween 80 and polyethylene glycol 40 obtain solution b after dissolution；
P3, Lavender and silicone are measured, propylene glycol is added to dilute, be uniformly mixed to obtain solution c；
P4, solution a and c are added in solution b, are uniformly mixed, obtain sulikol liquid dressing.
Compared with prior art, the invention has the following advantages that
1, a kind of sulikol liquid dressing of the present invention solves sulphur using sulikol substitution sulphur and is insoluble in water
The problem of, there is the protection of Arabic gum, reduce the volatility and easily oxidizable of sulphur, avoids smell when sulphur directly uses
The shortcomings that unpleasant and pollution clothes；Also, the protection of Arabic gum forms the slow-releasing system of sulikol, when keeping sulikol long
Between keep effect, and eliminate sulphur and skin directly largely contacts the adverse reaction of generation.In addition, such sulikol liquid
Dressing Easy dosing, preparation method and application method are simple and convenient, are suitable for industrialized production.
2, the purity for the rhubarb total anthraquinone that the present invention makes and uses reaches 80% or more, and avoiding rhubarb medicinal material directly makes
The interference of used time a large amount of impurity (such as tannic acid, steroidal) reduces the adverse reaction generated by impurity component.The present invention is also public together
The extracting method of rhubarb total anthraquinone is opened.It is reported that rhubarb total anthraquinone be often used the organic solvents such as ether, benzene, chloroform extract and
The total anthraquinones content of purification, general extract is no more than 20%, and the content of general anthraquinone is about left 50% in extractum rhei after purification
It is right.And design feature of the present invention according to rhubarb total anthraquinone, it is directly extracted using calcium hydroxide aqueous solution, and assisted with ultrasonic wave
Extraction method can extract 80% or more anthraquinone component in rheum officinale.
The preparation method of rhubarb total anthraquinone of the present invention makes the purity of rhubarb total anthraquinone can achieve 80% or more.
Laboratory compares the recovery rate and purity of different solvents soak extraction rhubarb total anthraquinone, as a result as follows:
1. different solvents of table are to the recovery rate of rhubarb total anthraquinone and the influence of purity.
It can illustrate that calcium hydroxide is high as the Extraction solvent recovery rate of rhubarb total anthraquinone by table 1, and rhubarb total anthraquinone
Purity it is higher, then after step S1~S6 is further purified, the purity of rhubarb total anthraquinone can reach 80%~95%.
3, anthraquinone is extracted using calcium hydroxide aqueous solution have the advantage that (1) calcium ion can precipitate tannic acid, resin
Constituents；(2) extraction with aqueous solution be extracted the lower steroidal of polarity, aglycon will not；(3) alkalinity of calcium hydroxide can
To extract 90% or more anthraquinone component；(4) extraction with aqueous solution is at low cost, safe and non-toxic, avoids organic solvent extraction
When the risks such as inflammable, toxic, danger coefficient is high, environmental pollution, expensive, organic solvent residual；(5) extracting method is simple,
It is easily operated, it can be with industrialized production.
4, a kind of sulikol liquid dressing of the present invention is skin caused by being exclusively used in helminth and microorganism infection
The treatment of disease, it is curative for effect, clinical application is safe and free of toxic and side effects.It is total to caused by curing acarid acne 83 over 3 years, controls
More rate is up to 98%；It treats trichomonas pruritus vulvue and demonstrate,proves 36, cure rate is up to 100%；Treatment tinea manuum and tinea pedis 32, cure rate reaches
96%.Therefore, a kind of sulikol liquid dressing of the present invention has a good application prospect.
5, sulikol liquid dressing formula science disclosed in this invention, preparation process is simple, easy to use, has and kills
The features such as worm, sterilization, antipruritic, promotion wound healing, inhibition scar form, repair and protect skin, is specially adapted for because of parasitism
The treatment of skin disease caused by worm and Institute of Micro-biology, especially suitable for acne, brandy nose, skin toxoplasmosis, trichomonas outer
The treatment of negative itch, tinea of feet and hands, onychomycosis, sweat stain, psoriasis, favus of the scalp, seborrhea, neurodermatitis.
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention will be further described, but the present invention is simultaneously
It is not limited to these embodiments.
The present invention will provide a kind of dedicated for skin disease caused by treatment helminth and microorganism using sulikol as main ingredient
The liquid dressing of disease.
Sulphur, it is sour, it is warm-natured, it is toxic, it is recorded in Shennong's Herbal earliest, external application removing toxic substances desinsection treats sore, takes orally and mend fire
Supporing yang defaecation.Sulphur curative effect in external therapy is prominent, especially in treating skin disease, there is recipe much containing sulphur, such as uses
In desinsection it is antipruritic eliminate (" surgery authentic ") completely, the litharge of wind dispelling insecticide dissipates (Golden Mirror of Medicine), controls " the fragrant sulphur of bi Zheng outside
Cake " (" ten thousand sick proved recipes are complete works of ") etc..
Studies have shown that sulphur has very strong desinsection itching-relieving action, particularly with the vermins sense such as scabies, pediculosis pubis
Associated diseases are contaminated, it is significant in efficacy.But there is also very big problems when in use for sulphur: curative effect is not good enough when sulphur concentration is less than normal, makes
The shortcomings that irritant big, smell is dense, clothes easy to pollute with the sulphur of therapeutic dose, while it is dry, tight to will appear mild skin
Taut sense, burning heat sensation, the adverse reaction of the similar contact dermatitis such as local flush, itch.In addition, making because sulphur is insoluble in water
Many inconvenient with existing in the process, method of application often occurs in the form of emulsion, in the form of solid state and skin contact, leads
Cause local concentration excessive, adverse reaction increases.Therefore, it the problem of how reducing the adverse reaction and use of sulphur, mentions
High its skin treating effect, becomes the highest priority of sulphur application study on skin disease.
Sulikol used in the present invention is a kind of sulfur granules made of sulphur and Arabic gum.Elementary sulfur is generally with S8
Form exist.Sulikol has very strong desinsection, mite killing, sterilization, antipruritic effect.Sulphur is in dermatology using mostly with emulsion
Form exist, the reason is that sulphur water solubility it is very poor.Sulikol solves the problems, such as that sulphur is insoluble in water, and Arabic gum exists
Microcapsules are formd in aqueous solution, wherein by sulphur powder protection, sulikol are uniformly distributed in water, are formed colloid
Solution.Due to there is the protection of Arabic gum, the volatility and easily oxidizable of sulphur are reduced, solves gas when sulphur directly uses
It smells foul and the problem of pollution clothes；Also, the protection of Arabic gum forms the slow-releasing system of sulikol, and sulikol is enable to grow
Time keeps effect, and eliminates sulphur and directly largely contact the adverse reaction of generation with skin.In addition, Arabic gum has
Film forming can form layer protecting film in skin surface, prevent external microbe from entering to invade the injury of harmful substance.Therefore,
Treatment of the present invention using sulikol as principle active component, for skin disease caused by helminth and microorganism infection.
Rhubarb total anthraquinone is the main active component of Chinese herb rhubarb, including rheum emodin, Rhein, aloe-emodin, rheum officinale
The effective components such as phenol, Physcion.Rhubarb total anthraquinone has anastalsis, can promote thrombocytopoiesis, hence it is evident that increases fiber
Proteinogen makes reduced clotting time, reduces capillary permeability, improves fragility of blood vessels, increases the contraction activity of blood vessel, from
And promote blood clotting.Furthermore rhubarb total anthraquinone has antibacterial action, there is different degrees of inhibiting effect to various bacteria,
In it is most sensitive with staphylococcus, streptococcus, shigella dysenteriae, corynebacterium diphtheriae, hay bacillus and typhoid bacillus etc. are also more sensitive.It is antibacterial
Mechanism is mainly to inhibit the oxidation and dehydrogenation of thallus sugar and metabolic intermediate, and can inhibit the synthesis of albumen and nucleic acid, therefore
It can avoid the toxicity and drug resistance of clinically certain antibiotic.Rhubarb total anthraquinone not only itself has broad-spectrum antibacterial action,
Also there is synergistic function to other antibacterials, and is not likely to produce drug resistance.The present invention matches rhubarb total anthraquinone and sulikol
5 use, and rheum officinale is cold in nature, clearing heat-fire removing toxic substances, but directly too strong using pharmacological property；Sulikol is warm-natured, and desinsection, which kills, itches, but sulphur poison
Property it is larger, directly contact skin-on-skin damage it is larger；The two pharmacological property is on the contrary, with the use of that can neutralize drug effect, enhancing drug is killed
Bacterium, desinsection, antipruritic effect play the role of hemostasis and promote wound healing, and can make up its side effect mutually, make medicine
Product can directly contact skin.
Hyaluronic acid is a kind of large biological molecule, most obtains early in extraction in buphthalmos, is the proper constituent of human body cell.It grinds
Study carefully display, hyaluronic acid can play the role of unique protection skin, skin moisturizing can be kept smooth, fine and smooth tender, high resilience,
Have the function of wrinkle resistant, crease-resistant, beauty and health care and restores skin physiology function.Applied hyaluronic acid is basic currently on the market
The upper polymer hyaluronic acid for molecular weight 100-120 ten thousand, primarily serves the effect of skin moisture-keeping.Present invention application ultra-low molecular
Hyaluronic acid, molecular weight is in 3000-10000, and researches show that ultra-low molecular hyaluronic acid can promote the proliferation of epidermal cell and divide
Change, accelerating wound healing, scavenging activated oxygen can prevent and repair skin injury.The present invention makees ultra-low molecular hyaluronic acid
The effects of adjuvant treatment ingredient after treating for sulikol plays the healing for accelerating skin wound, repairs skin injury.
Meanwhile the present invention is also prevented the dry skin being likely to occur in sulikol use process using ceramide, taken off
The situations such as bits, coarse；Ceramide can increase horny layer of epidermis thickness simultaneously, improve skin moisture holding capacity, reduce wrinkle, enhancing
Skin elasticity, delay skin aging.
The present invention in addition to above to the function of the treatment of skin problem and reparation other than, also have the function of remove scar.
Lavender is Labiatae lavender platymiscium.Lavender is refined by lavender, can be clearing heat and detoxicating,
Cleaning skin, controls oil, freckle removing and whitening, and the tender skin of anti-wrinkle, eye haustra -dsipelling black eye may additionally facilitate regeneration of damaged tissue recovery etc.
Skin-protecting function.Lavender also has sedation effect to heart, can reduce hypertension, pacify palpitaition, helpful for having a sleepless night.
Lavender energy rapid osmotic hair follicle disinfecting, antimicrobial promotes cytothesis, restores skin connective tissue, while balance skin table
Layer fat secretion, sensitive skin of releiving, convergence pore, supplement skin moisture, persistently protect skin not interfered by whelk acne,
Restore the moist skin of zero pore, zero small pox.
Silicone is a kind of stable chemical substance, non-toxic, nonirritant to skin, lubricates and is easy to be coated with, does not interfere
The normal function of skin, not pollution clothes, and have the effect of removing scar.The present invention carries out Lavender and silicone
Compounding, complements each other, and the effect of scar is gone in enhancing.And the present invention utilize propylene glycol and polyethylene glycol 40, Tween 80 and Ah
Draw primary glue, compounded insoluble with the Lavender of water and silicone, under the auxiliary of sulikol it is evenly dispersed in aqueous solution, make
For at liquid dressing, non-greasy is easy to use.
Invention also uses polyhexamethylene guanides to increase bactericidal effect of the invention, polyhexamethylene guanide as fungicide
It is a kind of environment-friendly type macromolecule polymer disinfection sanitizer, there is broad-spectrum；It is non-stimulated to skin, mucous membrane；Effective concentration is low；
Work fast；Property is stablized；Excellent performance soluble easily in water；It can use at normal temperature；It is long-term antibacterial, without side-effects；Without corruption
Corrosion；It is colourless, odorless；It is nontoxic；It is non-ignitable, not quick-fried, using safe；It is moderate；Convenient transportation is a kind of excellent fungicide.
To sum up, the shortcomings that this invention removes sulphur, and irritation is big during treating skin disease, pollutes clothes, reduces
The adverse reaction of sulphur, compatibility sulikol and rhubarb total anthraquinone, as sterilization, desinsection, hemostasis, antipruritic；Using ultralow
The film forming and biocompatibility of Arabic gum in molecular weight hyaluronic acid and sulikol form protective film in skin surface, every
The invasion of exhausted external substance；Promote wound healing and skin repair using the conduct of ultra-low molecular hyaluronic acid and rhubarb total anthraquinone
Agent；And the generation of application Lavender and silicone oil prevention scar；To make the present invention have sterilization, desinsection, hemostasis, it is antipruritic,
Promote wound healing, promote skin repair, prevention and the effect for removing scar, is specially adapted for drawing because of helminth and Institute of Micro-biology
The treatment of the skin disease risen, such as acne, skin toxoplasmosis, trichomonas pruritus vulvue, tinea of feet and hands, onychomycosis, sweat stain, psoriasis
Deng.
Embodiment 1
One, the preparation of rhubarb total anthraquinone
(1) rhubarb medicinal material crushes, and crosses 40 meshes, forms rhubarb medicinal material powder；
(2) calcium hydroxide takes supernatant spare after dissolution is added；
(3) rhubarb medicinal material powder is with calcium hydroxide supernatant ultrasonic wave assisted extraction 2 times, extracts 40min for the first time, and second
Secondary extraction 20min, wherein the mass ratio of rhubarb medicinal material powder and calcium hydroxide supernatant is 1:5；
(4) it filters, merging filtrate, is concentrated by ultrafiltration；
(5) to 3, precipitating, filtering precipitates salt acid for adjusting pH；
(6) pellet frozen is dry, obtains red rhubarb total anthraquinone powder；
(7) purity for detecting rhubarb total anthraquinone is 91.6%.
Two, the preparation of sulikol liquid dressing
Sulikol liquid dressing formula table
(1) 10 parts of sulikols are weighed, 1 part of rhubarb total anthraquinone dissolves in 40 parts of water, ultrasonic wave dissolution, obtain solution a1；
(2) 1 part of ultra-low molecular hyaluronic acid, 0.5 part of ceramide are weighed, is added in 22.8 parts of water and dissolves, add 0.2
Part polyhexamethylene guanide, 5 parts of Tween 80s and 1 part of polyethylene glycol 40, obtain solution b1；
(3) 0.5 part of Lavender and 8 parts of silicone are measured, is added in 10 parts of propylene glycol and dilutes, ultrasonic wave is uniformly mixed
Solution c1；
(4) by solution a1And c1Solution b is added1In, ultrasonic wave is uniformly mixed, and obtains sulikol liquid dressing.
Canned spray can be made in the liquid dressing, have desinsection, sterilization, antipruritic, promotion wound healing, inhibition scar shape
At, the advantages that repairing and protect skin, skin disease caused by specifically treating because of helminth and microorganism, especially suitable for Cuo
Sore, brandy nose, skin toxoplasmosis, trichomonas pruritus vulvue, tinea of feet and hands, onychomycosis, sweat stain, psoriasis, favus of the scalp, seborrheica skin
Scorching, neurodermatitis treatment.
Embodiment 2
One, the preparation of rhubarb total anthraquinone
(1) rhubarb medicinal material crushes, and crosses 40 meshes, forms rhubarb medicinal material powder；
(2) calcium hydroxide takes supernatant spare after dissolution is added；
(3) rhubarb medicinal material powder is with calcium hydroxide supernatant ultrasonic wave assisted extraction 2 times, extracts 40min for the first time, and second
Secondary extraction 20min, wherein the mass ratio of rhubarb medicinal material powder and calcium hydroxide supernatant is 1:5；
(4) it filters, merging filtrate, is concentrated by ultrafiltration；
(5) to 3, precipitating, filtering precipitates salt acid for adjusting pH；
(6) pellet frozen is dry, obtains red rhubarb total anthraquinone powder；
(7) purity for detecting rhubarb total anthraquinone is 91.6%.
Two, the preparation of sulikol liquid dressing
Sulikol liquid dressing formula table
(1) 8 parts of sulikols are weighed, 1 part of rhubarb total anthraquinone dissolves in 40 parts of water, ultrasonic wave dissolution, obtain solution a2；
(2) 1 part of ultra-low molecular hyaluronic acid, 0.5 part of ceramide are weighed, is added in 23.3 parts of water and dissolves, add 0.2
Part polyhexamethylene guanide, 5 parts of Tween 80s and 2 parts of polyethylene glycol 40, obtain solution b2；
(3) 1 part of Lavender and 8 parts of silicone are measured, is added in 10 parts of propylene glycol and dilutes, ultrasonic wave is uniformly mixed molten
Liquid c2；
(4) by solution a2And c2Solution b is added2In, ultrasonic wave is uniformly mixed, and obtains sulikol liquid dressing.
Patch can be made with non-woven fabrics is impregnated in the liquid dressing, have desinsection, sterilization, antipruritic, promotion wound healing, inhibition
The advantages that scar is formed, and is repaired and is protected skin, skin disease caused by specifically treating because of helminth and microorganism are particularly suitable
In acne, the treatment of skin toxoplasmosis.
Embodiment 3
One, the preparation of rhubarb total anthraquinone
(1) rhubarb medicinal material crushes, and crosses 40 meshes, forms rhubarb medicinal material powder；
(2) calcium hydroxide takes supernatant spare after dissolution is added；
(3) rhubarb medicinal material powder is with calcium hydroxide supernatant ultrasonic wave assisted extraction 2 times, extracts 40min for the first time, and second
Secondary extraction 20min, wherein the mass ratio of rhubarb medicinal material powder and calcium hydroxide supernatant is 1:5；
(4) it filters, merging filtrate, is concentrated by ultrafiltration；
(5) to 3, precipitating, filtering precipitates salt acid for adjusting pH；
(6) pellet frozen is dry, obtains red rhubarb total anthraquinone powder；
(7) purity for detecting rhubarb total anthraquinone is 91.6%.
Two, the preparation of sulikol liquid dressing
Sulikol liquid dressing formula table
(1) 10 parts of sulikols are weighed, 1 part of rhubarb total anthraquinone dissolves in 40 parts of water, ultrasonic wave dissolution, obtain solution a3；
(2) 1 part of ultra-low molecular hyaluronic acid, 0.5 part of ceramide are weighed, is added in 21.3 parts of water and dissolves, add 0.2
Part polyhexamethylene guanide, 5 parts of Tween 80s and 2 parts of polyethylene glycol 40, obtain solution b3；
(3) 1 part of Lavender and 8 parts of silicone are measured, is added in 10 parts of propylene glycol and dilutes, ultrasonic wave is uniformly mixed molten
Liquid c3；
(4) by solution a3And c3Solution b is added3In, ultrasonic wave is uniformly mixed, and obtains sulikol liquid dressing.
The liquid dressing canned ballpoint agent can be made into ballpoint device, have desinsection, sterilization, it is antipruritic, promote wound healing,
The advantages that inhibiting scar to be formed, repair and protect skin, skin disease caused by specifically treating because of helminth and microorganism, especially
Suitable for acne, tinea of feet and hands, sweat stain, psoriasis treatment.
Embodiment 4
One, the preparation of rhubarb total anthraquinone
(1) rhubarb medicinal material crushes, and crosses 40 meshes, forms rhubarb medicinal material powder；
(2) calcium hydroxide takes supernatant spare after dissolution is added；
(3) rhubarb medicinal material powder is with calcium hydroxide supernatant ultrasonic wave assisted extraction 2 times, extracts 40min for the first time, and second
Secondary extraction 20min, wherein the mass ratio of rhubarb medicinal material powder and calcium hydroxide supernatant is 1:5；
(4) it filters, merging filtrate, is concentrated by ultrafiltration；
(5) to 3, precipitating, filtering precipitates salt acid for adjusting pH；
(6) pellet frozen is dry, obtains red rhubarb total anthraquinone powder；
(7) purity for detecting rhubarb total anthraquinone is 91.6%.
Two, the preparation of sulikol liquid dressing
Sulikol liquid dressing formula table
(1) 12 parts of sulikols are weighed, 1 part of rhubarb total anthraquinone dissolves in 40 parts of water, ultrasonic wave dissolution, obtain solution a4；
(2) 1 part of ultra-low molecular hyaluronic acid, 0.5 part of ceramide are weighed, is added in 19.3 parts of water and dissolves, add 0.2
Part polyhexamethylene guanide, 5 parts of Tween 80s and 2 parts of polyethylene glycol 40, obtain solution b4；
(3) 1 part of Lavender and 8 parts of silicone are measured, is added in 10 parts of propylene glycol and dilutes, ultrasonic wave is uniformly mixed molten
Liquid c4；
(4) by solution a4And c4Solution b is added4In, ultrasonic wave is uniformly mixed, and obtains sulikol liquid dressing.
The liquid dressing canned can have desinsection, sterilization, antipruritic, promotion wound healing, inhibition scar to be formed at lotion,
The advantages that repairing and protecting skin, skin disease caused by specifically treating because of helminth and microorganism, especially suitable for trichomonas
The treatment of pudendal pruritus.
Embodiment 5
One, the preparation of rhubarb total anthraquinone
(1) rhubarb medicinal material crushes, and crosses 60 meshes, forms rhubarb medicinal material powder；
(2) calcium hydroxide takes supernatant spare after dissolution is added；
(3) rhubarb medicinal material powder is with calcium hydroxide supernatant ultrasonic wave assisted extraction 2 times, extracts 60min for the first time, and second
Secondary extraction 30min, wherein the mass ratio of rhubarb medicinal material powder and calcium hydroxide supernatant is 1:4；
(4) it filters, merging filtrate, is concentrated by ultrafiltration；
(5) to 3.5, precipitating, filtering precipitates salt acid for adjusting pH；
(6) pellet frozen is dry, obtains red rhubarb total anthraquinone powder；
(7) purity for detecting rhubarb total anthraquinone is 90.2%.
Two, the preparation of sulikol liquid dressing
Sulikol liquid dressing formula table
(1) 8 parts of sulikols are weighed, 0.8 part of rhubarb total anthraquinone dissolves in 50 parts of water, ultrasonic wave dissolution, obtain solution a5；
(2) 1.2 parts of ultra-low molecular hyaluronic acids, 0.6 part of ceramide are weighed, is added in 28 parts of water and dissolves, add 0.3
Part polyhexamethylene guanide, 3 parts of Tween 80s and 2 parts of polyethylene glycol 40, obtain solution b5；
(3) 1 part of Lavender and 13 parts of silicone are measured, is added in 8 parts of propylene glycol and dilutes, ultrasonic wave is uniformly mixed molten
Liquid c5；
(4) by solution a5And c5Solution b is added5In, ultrasonic wave is uniformly mixed, and obtains sulikol liquid dressing.
Patch can be made with non-woven fabrics is impregnated in the liquid dressing, have desinsection, sterilization, antipruritic, promotion wound healing, inhibition
The advantages that scar is formed, and is repaired and is protected skin, skin disease caused by specifically treating because of helminth and microorganism are particularly suitable
In acne, the treatment of skin toxoplasmosis.
Embodiment 6
One, the preparation of rhubarb total anthraquinone
(1) rhubarb medicinal material crushes, and crosses 30 meshes, forms rhubarb medicinal material powder；
(2) calcium hydroxide takes supernatant spare after dissolution is added；
(3) rhubarb medicinal material powder extracts 120min, wherein rheum officinale with calcium hydroxide supernatant ultrasonic wave assisted extraction 1 time
The mass ratio of medicinal powder and calcium hydroxide supernatant is 1:6；
(4) it filters, merging filtrate, is concentrated by ultrafiltration；
(5) to 2.8, precipitating, filtering precipitates salt acid for adjusting pH；
(6) pellet frozen is dry, obtains red rhubarb total anthraquinone powder；
(7) purity for detecting rhubarb total anthraquinone is 83.3%.
Two, the preparation of sulikol liquid dressing
Sulikol liquid dressing formula table
(1) 12 parts of sulikols are weighed, 1.2 parts of rhubarb total anthraquinones dissolve in 38 parts of water, ultrasonic wave dissolution, obtain solution a6；
(2) 0.8 part of ultra-low molecular hyaluronic acid, 1.5 parts of ceramides are weighed, is added in 12 parts of water and dissolves, add 0.4
Part polyhexamethylene guanide, 2 parts of Tween 80s and 2.5 parts of polyethylene glycol 40, obtain solution b6；
(3) 0.2 part of Lavender and 5 parts of silicone are measured, is added in 6 parts of propylene glycol and dilutes, ultrasonic wave is uniformly mixed
Solution c6；
(4) by solution a6And c6Solution b is added6In, ultrasonic wave is uniformly mixed, and obtains sulikol liquid dressing.
The liquid dressing canned ballpoint agent can be made into ballpoint device, have desinsection, sterilization, it is antipruritic, promote wound healing,
The advantages that inhibiting scar to be formed, repair and protect skin, skin disease caused by specifically treating because of helminth and microorganism, especially
Suitable for acne, tinea of feet and hands, sweat stain, psoriasis treatment.
Embodiment 7
One, the preparation of rhubarb total anthraquinone
(1) rhubarb medicinal material crushes, and crosses 50 meshes, forms rhubarb medicinal material powder；
(2) calcium hydroxide takes supernatant spare after dissolution is added；
(3) rhubarb medicinal material powder is with calcium hydroxide supernatant ultrasonic wave assisted extraction 2 times, extracts 50min for the first time, and second
Secondary extraction 25min, wherein the mass ratio of rhubarb medicinal material powder and calcium hydroxide supernatant is 1:7；
(4) it filters, merging filtrate, is concentrated by ultrafiltration；
(5) to 3.2, precipitating, filtering precipitates salt acid for adjusting pH；
(6) pellet frozen is dry, obtains red rhubarb total anthraquinone powder；
(7) purity for detecting rhubarb total anthraquinone is 87.9%.
Two, the preparation of sulikol liquid dressing
Sulikol liquid dressing formula table
(1) 15 parts of sulikols are weighed, 3 parts of rhubarb total anthraquinones dissolve in 52 parts of water, ultrasonic wave dissolution, obtain solution a7；
(2) 2.5 parts of ultra-low molecular hyaluronic acids, 2 parts of ceramides are weighed, is added in 28 parts of water and dissolves, add 0.5 part
Polyhexamethylene guanide, 4 parts of Tween 80s and 3 parts of polyethylene glycol 40, obtain solution b7；
(3) 0.3 part of Lavender and 15 parts of silicone are measured, is added in 9 parts of propylene glycol and dilutes, ultrasonic wave is uniformly mixed
Solution c7；
(4) by solution a7And c7Solution b is added7In, ultrasonic wave is uniformly mixed, and obtains sulikol liquid dressing.
The liquid dressing canned can have desinsection, sterilization, antipruritic, promotion wound healing, inhibition scar to be formed at lotion,
The advantages that repairing and protecting skin, skin disease caused by specifically treating because of helminth and microorganism, especially suitable for trichomonas
The treatment of pudendal pruritus.
Claims (10)
1. a kind of sulikol liquid dressing, which is characterized in that according to parts by weight, including following components:
0.5~15 part of sulikol；
0.5~5 part of rhubarb total anthraquinone；
39.5~84.9 parts of water；
The sulikol is the drusen that sulphur and Arabic gum are prepared into, the Arabic gum be coated on outside sulphur formed it is micro-
Capsule, the microcapsules can be uniformly distributed in water, form colloidal solution.
2. a kind of sulikol liquid dressing according to claim 1, which is characterized in that according to parts by weight, including it is following
Component:
0.5~10 part of sulikol；
1~5 part of rhubarb total anthraquinone；
49.5~80.4 parts of water.
3. a kind of sulikol liquid dressing according to claim 1, which is characterized in that in the sulikol sulphur and I
The mass ratio of primary glue is 1:2~5.
4. a kind of sulikol liquid dressing according to claim 1, which is characterized in that the sulikol and rhubarb total anthraquinone
Weight ratio be 8~12:1.
5. a kind of sulikol liquid dressing according to claim 1, which is characterized in that the preparation side of the rhubarb total anthraquinone
Method the following steps are included:
S1, rhubarb medicinal material is crushed, is sieved；
S2, calcium hydroxide are added to the water dissolution, take supernatant spare；
S3, rhubarb medicinal material powder is extracted using calcium hydroxide supernatant；
S4, it is filtered, ultrafiltration is carried out after the completion of filtering；
S5, pH is adjusted to 2~4 using acidic materials, precipitating, filtering precipitates；
S6, the pellet frozen in step S5 is dried, obtains rhubarb total anthraquinone.
6. a kind of sulikol liquid dressing according to claim 5, which is characterized in that in the step S3, using ultrasound
The mass ratio of wave assisted extraction, rhubarb medicinal material powder and calcium hydroxide supernatant is 1:3~10.
7. a kind of sulikol liquid dressing according to claim 1, which is characterized in that the sulikol liquid dressing also wraps
Include following components:
8. a kind of sulikol liquid dressing according to claim 7, which is characterized in that the sulikol liquid dressing also wraps
Include following components:
9. a kind of sulikol liquid dressing according to claim 7, which is characterized in that the ultra-low molecular hyaluronic acid
Molecular weight is 3000~10000.
10. a kind of preparation method of sulikol liquid dressing described in any one according to claim 1~9, which is characterized in that
The following steps are included:
P1, weigh sulikol, rhubarb total anthraquinone is added to the water, ultrasonic wave dissolution, obtain solution a；
P2, it weighs ultra-low molecular hyaluronic acid, after ceramide is added to the water dissolution, adds polyhexamethylene guanide, Tween 80
With polyethylene glycol 40, solution b is obtained after dissolution；
P3, Lavender and silicone are measured, propylene glycol is added to dilute, be uniformly mixed to obtain solution c；
P4, solution a and c are added in solution b, are uniformly mixed, obtain sulikol liquid dressing.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112316050A (en) * | 2020-11-09 | 2021-02-05 | 杭州宏果科技有限公司 | Antibacterial nursing lotion and application thereof |
| CN113425666A (en) * | 2021-07-06 | 2021-09-24 | 科丝美诗(中国)化妆品有限公司 | Composition for removing acne and repairing skin barrier as well as preparation method and application thereof |
| CN114272155A (en) * | 2021-10-27 | 2022-04-05 | 纳爱斯丽水日化有限公司 | Cleaning composition containing colloidal sulfur |
| CN114712254A (en) * | 2021-10-08 | 2022-07-08 | 东莞市羽馨化妆品有限公司 | Coated colloidal sulfur and preparation method and application thereof |
| CN117982345A (en) * | 2024-01-12 | 2024-05-07 | 佛山诗华莎新材料有限公司 | Colloidal sulfur anti-inflammatory antibacterial agent and preparation method and application thereof |
| CN118021628A (en) * | 2024-01-23 | 2024-05-14 | 深圳市羽素生物科技有限公司 | Easily-dispersible sulfur microcapsule and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101198308A (en) * | 2005-06-13 | 2008-06-11 | 3M创新有限公司 | Foamable alcohol compositions, systems and methods of use |
| CN101534802A (en) * | 2006-11-01 | 2009-09-16 | 希尔瑞特有限公司 | Sanitizing surfaces |
| CN103110864A (en) * | 2011-11-16 | 2013-05-22 | 吴克 | Nose care cream |
-
2018
- 2018-12-26 CN CN201811599050.0A patent/CN109646712B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101198308A (en) * | 2005-06-13 | 2008-06-11 | 3M创新有限公司 | Foamable alcohol compositions, systems and methods of use |
| CN101534802A (en) * | 2006-11-01 | 2009-09-16 | 希尔瑞特有限公司 | Sanitizing surfaces |
| CN103110864A (en) * | 2011-11-16 | 2013-05-22 | 吴克 | Nose care cream |
Non-Patent Citations (1)
| Title |
|---|
| 袁端锋等: "冰黄肤乐凝胶剂的制备及其止痒作用的研究", 《山西医药杂志》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112316050A (en) * | 2020-11-09 | 2021-02-05 | 杭州宏果科技有限公司 | Antibacterial nursing lotion and application thereof |
| CN113425666A (en) * | 2021-07-06 | 2021-09-24 | 科丝美诗(中国)化妆品有限公司 | Composition for removing acne and repairing skin barrier as well as preparation method and application thereof |
| CN114712254A (en) * | 2021-10-08 | 2022-07-08 | 东莞市羽馨化妆品有限公司 | Coated colloidal sulfur and preparation method and application thereof |
| CN114272155A (en) * | 2021-10-27 | 2022-04-05 | 纳爱斯丽水日化有限公司 | Cleaning composition containing colloidal sulfur |
| CN117982345A (en) * | 2024-01-12 | 2024-05-07 | 佛山诗华莎新材料有限公司 | Colloidal sulfur anti-inflammatory antibacterial agent and preparation method and application thereof |
| CN117982345B (en) * | 2024-01-12 | 2024-07-05 | 佛山诗华莎新材料有限公司 | Colloidal sulfur anti-inflammatory antibacterial agent and preparation method and application thereof |
| CN118021628A (en) * | 2024-01-23 | 2024-05-14 | 深圳市羽素生物科技有限公司 | Easily-dispersible sulfur microcapsule and preparation method and application thereof |
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