CN109646712B - Colloidal sulfur liquid dressing and preparation method thereof - Google Patents

Colloidal sulfur liquid dressing and preparation method thereof Download PDF

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CN109646712B
CN109646712B CN201811599050.0A CN201811599050A CN109646712B CN 109646712 B CN109646712 B CN 109646712B CN 201811599050 A CN201811599050 A CN 201811599050A CN 109646712 B CN109646712 B CN 109646712B
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陈勇
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Beijing Underproved Medical Technology Co ltd
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract

The invention relates to the technical field of medicines, and provides a colloidal sulfur liquid dressing and a preparation method thereof. The invention takes colloidal sulfur, rhubarb total anthraquinone, ultra-low molecular hyaluronic acid, ceramide, lavender essential oil and silicone as main active ingredients, thus solving the problem that the sulfur is difficult to dissolve in water; the volatility and the oxidability of the sulfur are reduced, and the defects of bad smell and clothes pollution when the sulfur is directly used are avoided; eliminates adverse reaction caused by direct contact of sulfur and skin. The invention has the advantages of killing parasite, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin, and is particularly suitable for treating acne, rosacea, toxoplasmosis of skin, trichomonas vulvar pruritus, tinea manus and pedis, onychomycosis, sweat stain, psoriasis, tinea capitis, seborrheic dermatitis and neurodermatitis. The preparation method of the colloidal sulfur liquid dressing disclosed by the invention is scientific in formula, simple in preparation process and convenient to use, and can be used for industrial production.

Description

Colloidal sulfur liquid dressing and preparation method thereof
Technical Field
The invention belongs to the technical field of medicines, relates to a liquid dressing, and particularly relates to a colloidal sulfur liquid dressing and a preparation method thereof.
Background
The skin is wrapped on the surface of human body, accounts for about 16% of human body weight, and is in direct contact with external environment, and has the functions of protecting, feeling, secreting, excreting, breathing, etc. The skin is the largest organ of the human body, and diseases caused by skin damage are various and have complex causes. Of these, skin diseases caused by mechanical skin injuries (e.g., wounds) and biological skin injuries (e.g., parasitic or microbial infections) are most common.
At present, the main principle of the medicaments for treating the skin diseases caused by the parasites and the microorganisms in the market is that silver ions, sulfur, antibiotics or other medicaments for treating the skin diseases caused by the parasites and the microorganisms are added into the medicaments, so that the medicaments have better treatment effect. However, the medicaments are in contact with the skin in the form of emulsion or paste, the absorbability is poor, the medicaments can be completely absorbed after being smeared for a long time, and the smeared skin has greasy feeling, so pores can be blocked after long-time use, and the breathing of the skin is influenced; when the cream or ointment is used, the medicine concentration of local skin is too high, and other adverse reactions are caused.
The liquid dressing is a solution for debridement, irrigation, moistening acute and chronic wounds, ulcers, incisions, abrasions and burns in the medical industry, is in contact with the skin in a liquid form, is easy to absorb by a human body, has a quick effect, does not produce side effects after being used for a long time, and greatly improves the using effect and the application range of a medicament if the medicament for treating skin diseases caused by parasites and microorganisms is made into the liquid dressing. The existing liquid dressings mainly focus on the treatment of slight wounds, such as "a liquid dressing and a preparation method thereof" (CN201711214230) and "a multifunctional liquid dressing and a preparation method thereof" (CN201610553348) and the like, and the main effects of the liquid dressings are that the treatment aims are achieved by protecting the wound environment, promoting the wound healing and preventing the wound infection, and no treatment effect is available on skin diseases caused by parasites and microorganisms. The patent "a liquid dressing for external use for treating skin diseases and a preparation method and a using method thereof" (CN201810819756) discloses a liquid dressing for treating psoriasis, which has simple raw materials and method, but mechanism and side effect are not clear, and can not be used for treating skin diseases infected by parasites and microorganisms. Also, skin diseases caused by parasites and microorganisms are often accompanied by various symptoms such as rash, itching, trauma, scars, etc., which are not solved by the above-mentioned liquid dressings.
The main reasons that the existing liquid dressing can not solve the skin diseases caused by parasites and microorganisms are as follows: 1. most of the medicaments for treating the skin diseases caused by the parasites and the microorganisms are difficult to dissolve in water, and the water cannot be used as a medicament solution, so that the medicaments for treating the skin diseases caused by the parasites and the microorganisms can only be prepared into emulsion or paste; 2. even if a few medicaments for treating skin diseases caused by parasites and microorganisms are soluble in water to prepare a solution, the medicament property is optimal when contacting the skin, and the medicament can quickly take effect, but the persistence is poor, and the efficacy cannot be maintained for a long time; 3. the medicament for treating the skin diseases caused by the parasites and the microorganisms is dissolved in water, and can be directly contacted with the skin when in use, and the skin can generate adverse reactions if contacted with the medicament for a long time.
Disclosure of Invention
The invention aims to solve the problems in the prior art, avoid inconvenience and adverse reaction of medicaments in use and provide a colloidal sulfur liquid dressing specially used for treating skin diseases caused by parasites and microorganisms.
The purpose of the invention can be realized by the following technical scheme: the colloidal sulfur liquid dressing comprises the following components in parts by weight:
0.5-15 parts of colloidal sulfur;
0.5-5 parts of total rhubarb anthraquinone;
39.5-84.9 parts of water;
the colloidal sulfur is sulfur particles prepared from sulfur and Arabic gum, the Arabic gum is coated outside the sulfur to form microcapsules, and the microcapsules can be uniformly distributed in water to form a colloidal solution.
The working principle of the invention is as follows: according to the colloidal sulfur liquid dressing, colloidal sulfur is adopted to replace sulfur, so that the problem that the sulfur is difficult to dissolve in water is solved; the gum arabic is protected to form a slow release system of the colloidal sulfur, so that the colloidal sulfur can keep efficacy for a long time; and the Arabic gum has film forming property, can form a layer of protective film on the surface of the skin, eliminates adverse reaction generated by direct contact of sulfur and the skin in large quantity, and prevents invasion of external microorganisms and harm of harmful substances.
Preferably, the colloidal sulfur liquid dressing comprises the following components in parts by weight:
0.5-10 parts of colloidal sulfur;
1-5 parts of total rhubarb anthraquinone;
49.5-80.4 parts of water.
Preferably, the sulfur is nano-scale sulfur, the colloidal sulfur is nano-scale sulfur particles prepared from the nano-scale sulfur and Arabic gum, the Arabic gum is coated outside the nano-scale sulfur to form microcapsules, and the microcapsules can be uniformly distributed in water to form a colloidal solution.
Preferably, the mass ratio of the sulfur to the Arabic gum in the colloidal sulfur is 1: 2-5.
Preferably, the colloidal sulfur is nano-sulfur particles prepared from 75% nano-sulfur and 25% gum arabic of the united states pharmacopeia grade (USP grade).
Preferably, the weight ratio of the colloidal sulfur to the total anthraquinone in rheum officinale is 8-12: 1.
preferably, the preparation method of the rhubarb total anthraquinone comprises the following steps:
s1, pulverizing radix et rhizoma Rhei, and sieving;
s2, adding calcium hydroxide into water for dissolving, and taking supernatant for later use;
s3, extracting rhubarb medicinal material powder by using the calcium hydroxide supernatant;
s4, filtering, and performing ultrafiltration after filtering is completed;
s5, adjusting the pH to 2-4 by adopting an acidic substance, precipitating, and filtering the precipitate; the pH is determined according to the acidity of the total anthraquinone, and when the pH is less than 2, the anthraquinone substances are unstable in chemical property and difficult to extract; when the pH is more than 4, all anthraquinone substances cannot be precipitated, so that the extraction rate is reduced;
s6, freeze-drying the precipitate obtained in the step S5 to obtain the rhubarb total anthraquinone.
Preferably, in step S3, ultrasonic-assisted extraction is adopted, the mass ratio of the powder of the rhubarb medicinal material to the supernatant of the calcium hydroxide is 1: 3-10, the mass ratio is determined according to the volume of the medicinal material, the medicinal part of the rhubarb is root, and the volume of the supernatant of the calcium hydroxide is preferably 5-20% (volume ratio) more calcium hydroxide supernatant after the rhubarb is submerged.
Preferably, the purity of the total anthraquinone of the rhubarb prepared by the method is not less than 80 percent.
Preferably, the colloidal sulfur liquid dressing further comprises the following components:
Figure BDA0001922002700000041
preferably, the colloidal sulfur liquid dressing further comprises the following components:
Figure BDA0001922002700000042
Figure BDA0001922002700000051
preferably, the molecular weight of the ultra-low molecular weight hyaluronic acid is 3000-10000.
Preferably, the colloidal sulfur liquid dressing is specially used for treating skin diseases caused by parasites and microorganisms, and is particularly suitable for treating acne, rosacea, toxoplasmosis of skin, trichomonas vulva pruritus, tinea manus and pedis, onychomycosis, tinea versicolor, psoriasis, tinea capitis, seborrheic dermatitis and neurodermatitis.
Preferably, the colloidal sulfur liquid dressing is applied by spraying, smearing, washing, bead-moving and sticking.
A preparation method of the colloidal sulfur liquid dressing comprises the following steps:
p1, weighing colloidal sulfur and total rhubarb anthraquinone, adding the colloidal sulfur and the total rhubarb anthraquinone into water, and dissolving the mixture by ultrasonic waves to obtain a solution a;
p2, weighing ultralow molecular sodium hyaluronate and ceramide, adding the ultralow molecular sodium hyaluronate and ceramide into water for dissolving, then adding polyhexamethylene guanidine, tween 80 and polyethylene glycol 40, and dissolving to obtain a solution b;
p3, weighing lavender essential oil and silicone, adding propylene glycol for dilution, and mixing uniformly to obtain a solution c;
and P4, adding the solution a and the solution c into the solution b, and uniformly mixing to obtain the colloidal sulfur liquid dressing.
Compared with the prior art, the invention has the following advantages:
1. the colloidal sulfur liquid dressing provided by the invention adopts colloidal sulfur to replace sulfur, so that the problem that the sulfur is difficult to dissolve in water is solved, the gum arabic is protected, the volatility and the oxidability of the sulfur are reduced, and the defects that the sulfur smells bad and pollutes clothes when being directly used are avoided; in addition, the gum arabic is protected to form a slow release system of the colloidal sulfur, so that the colloidal sulfur can keep the efficacy for a long time, and adverse reactions generated by direct and large-scale contact of the sulfur and the skin are eliminated. In addition, the colloidal sulfur liquid dressing has simple ingredients, simple and convenient preparation method and use method, and is suitable for industrial production.
2. The purity of the total anthraquinone in rhubarb prepared and used by the invention reaches more than 80 percent, thereby avoiding the interference of a large amount of impurities (such as tannic acid, steroids and the like) when the rhubarb is directly used and reducing the adverse reaction caused by the impurity components. The invention also discloses an extraction method of the rhubarb total anthraquinone. The rhubarb total anthraquinone is reported to be extracted and refined by organic solvents such as ether, benzene, chloroform and the like, the total anthraquinone content of the general extract is not more than 20 percent, and the total anthraquinone content in the refined rhubarb extract is about 50 percent. According to the structural characteristics of the total anthraquinone in rhubarb, the invention applies the aqueous solution of calcium hydroxide to directly extract, and can extract more than 80 percent of anthraquinone components in rhubarb by an ultrasonic-assisted extraction method.
The preparation method of the total anthraquinone in rhubarb provided by the invention enables the purity of the total anthraquinone in rhubarb to reach more than 80%. The extraction rate and purity of the rhubarb total anthraquinone extracted by soaking in different solvents are compared in a laboratory, and the result is as follows:
TABLE 1 influence of different solvents on the extraction yield and purity of total anthraquinone in rhubarb.
Figure BDA0001922002700000061
Table 1 shows that the extraction rate of calcium hydroxide as the extraction solvent of total anthraquinone is high, and the purity of total anthraquinone is high, and after further purification through steps S1-S6, the purity of total anthraquinone can reach 80% -95%.
3. The application of the calcium hydroxide aqueous solution to extract the anthraquinone has the following advantages: (1) the calcium ion can precipitate tannic acid and resin components; (2) extracting with water solution to prevent the extraction of steroid and aglycone with low polarity; (3) the alkalinity of the calcium hydroxide can extract more than 90 percent of anthraquinone components; (4) the aqueous solution has low extraction cost, is safe and nontoxic, and avoids the risks of flammability, toxicity, high danger coefficient, environmental pollution, high price, organic solvent residue and the like during the extraction of an organic solvent; (5) the extraction method is simple, easy to operate and suitable for industrial production.
4. The colloidal sulfur liquid dressing is specially used for treating skin diseases caused by parasites and microbial infection, and has the advantages of definite curative effect, safe clinical application and no toxic or side effect. 83 cases of acne caused by mites are cured in 3 years, and the cure rate reaches 98%; 36 cases of trichomonas vulvar pruritus can be treated, and the cure rate reaches 100 percent; 32 cases of treating tinea manus and pedis, the cure rate reaches 96 percent. Therefore, the colloidal sulfur liquid dressing has a good application prospect.
5. The colloidal sulfur liquid dressing disclosed by the invention has the characteristics of scientific formula, simple preparation process and convenience in use, has the characteristics of killing insects, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin and the like, is specially suitable for treating skin diseases caused by parasites and microorganisms, and is particularly suitable for treating acne, rosacea, skin toxoplasmosis, trichomonas vulvar pruritus, tinea manus and pedis, onychomycosis, sweat stains, psoriasis, tinea capitis, seborrheic dermatitis and neurodermatitis.
Detailed Description
The following are specific examples of the present invention and further describe the technical solutions of the present invention, but the present invention is not limited to these examples.
The invention provides a liquid dressing which is specially used for treating skin diseases caused by parasites and microorganisms by taking colloidal sulfur as a main drug.
Sulfur, sour in flavor, warm in nature and toxic, was first recorded in Shen nong Ben Cao Jing (Shen nong's herbal), and is externally used for removing toxicity, killing parasites, treating sores, and internally used for tonifying fire, supporting yang and relaxing bowels. Sulfur has outstanding curative effect in external treatment, especially in the treatment of skin diseases, there are many famous recipes containing sulfur, such as Yixiao for killing parasites and relieving itching (the "orthodox of surgery"), Lithargyrum powder for dispelling wind and killing parasites (the "medical science and gold references"), and "Xiangsuo cake" for treating arthralgia syndrome by external treatment (the "general of all proved recipes for diseases"), etc.
Research shows that the sulfur has strong insecticidal and antipruritic effects, and especially has obvious curative effect on diseases caused by ectoparasite infection such as scabies, pubic phthiriasis and the like. However, sulfur also has a great problem in use: when the sulfur concentration is slightly low, the curative effect is poor, the sulfur used in the therapeutic dose has the defects of large irritation, thick smell and easy pollution to clothes, and meanwhile, the adverse reactions of mild skin dryness, tightness, burning sensation, local flushing, pruritus and the like similar to contact dermatitis can occur. In addition, because sulfur is difficult to dissolve in water, a lot of inconvenience exists in the using process, the application mode often appears in the form of emulsion, and the sulfur is contacted with the skin in a solid state, so that the local concentration is too high, and the adverse reaction is increased. Therefore, how to reduce the adverse reaction of sulfur and the problems existing in the use of sulfur and improve the skin treatment effect of sulfur becomes a key target of the application research of sulfur on skin diseases.
The colloidal sulfur used in the present invention is a sulfur particle made of sulfur and gum arabic. Elemental sulfur is generally present in the form of S8. The colloidal sulfur has strong insecticidal, acaricidal, bactericidal and antipruritic effects. Sulfur is often used in dermatology in the form of an emulsion due to its poor water solubility. The colloidal sulfur solves the problem that the sulfur is difficult to dissolve in water, the Arabic gum forms microcapsules in the water solution, and the sulfur powder is protected in the microcapsules, so that the colloidal sulfur can be uniformly distributed in the water to form a colloidal solution. Due to the protection of the Arabic gum, the volatility and the oxidability of the sulfur are reduced, and the problems of bad smell and clothes pollution when the sulfur is directly used are solved; in addition, the gum arabic is protected to form a slow release system of the colloidal sulfur, so that the colloidal sulfur can keep the efficacy for a long time, and adverse reactions generated by direct and large-scale contact of the sulfur and the skin are eliminated. In addition, the Arabic gum has film forming property, and can form a protective film on the surface of skin to prevent the invasion of external microorganisms and the damage of harmful substances. Therefore, the invention uses the colloidal sulfur as the main effective component and is used for treating the skin diseases caused by parasites and microbial infection.
The total anthraquinone is the main effective component of Chinese medicine rhubarb, including emodin, rheinic acid, aloe-emodin, chrysophanol, physcion, etc. The total anthraquinone has hemostatic effect, and can promote thrombopoiesis, increase fibrinogen, shorten blood coagulation time, reduce capillary permeability, improve blood vessel fragility, increase vasoconstriction activity, and promote blood coagulation. In addition, the total anthraquinone in rhubarb has antibacterial effect and has different degrees of inhibition effect on various bacteria, wherein staphylococcus and streptococcus are most sensitive, and dysentery bacillus, diphtheria bacillus, bacillus subtilis, typhoid bacillus and the like are also more sensitive. The bacteriostasis mechanism mainly inhibits the oxidation and dehydrogenation of thalli sugar and metabolic intermediate products and can inhibit the synthesis of protein and nucleic acid, thereby avoiding the toxic and side reaction and drug resistance of some clinical antibiotics. The total anthraquinone not only has broad-spectrum antibacterial action, but also has synergistic action on other antibacterial drugs, and is not easy to generate drug resistance. The rhubarb total anthraquinone is compatible with the colloidal sulfur for use, and the rhubarb is cold in nature, can clear heat, purge fire and detoxify, but has too strong medicinal property when being directly used; the colloidal sulfur is warm in nature, kills insects and itch, but the sulfur has higher toxicity and causes more damage to the skin when directly contacting the skin; the two have opposite medicinal properties, and can neutralize the medicinal effect when used together, enhance the effects of sterilization, disinsection and itching relief of the medicine, play the roles of stopping bleeding and promoting wound healing, and can mutually compensate the side effects of the medicine, so that the medicine can directly contact the skin.
Hyaluronic acid is a biological macromolecule, is extracted from bovine eyes at the earliest time, and is an inherent component of human cells. Research shows that hyaluronic acid can play a unique role in protecting skin, can keep skin moist, smooth, fine, tender and elastic, and has the functions of preventing wrinkles, resisting wrinkles, beautifying, protecting health and recovering physiological functions of skin. The hyaluronic acid applied in the market at present is basically high molecular hyaluronic acid with the molecular weight of 100-120 ten thousand, and mainly plays a role in moisturizing skin. The invention applies the ultra-low molecular hyaluronic acid with the molecular weight of 3000-10000, and researches show that the ultra-low molecular hyaluronic acid can promote the proliferation and differentiation of epidermal cells, accelerate wound healing, clear oxygen free radicals and prevent and repair skin injury. The invention takes the ultra-low molecular hyaluronic acid as an auxiliary treatment component after colloidal sulfur treatment, and has the effects of accelerating the healing of skin wounds, repairing skin injuries and the like.
Meanwhile, the invention also uses ceramide to prevent the conditions of dry skin, desquamation, roughness and the like which can occur in the using process of the colloidal sulfur; meanwhile, ceramide can increase the thickness of the horny layer of epidermis, improve the water holding capacity of the skin, reduce wrinkles, enhance the elasticity of the skin and delay the skin aging.
The invention has the function of removing scars in addition to the function of treating and repairing the skin problems.
Lavender is plant of Lavandula of Labiatae. The lavender essential oil is extracted from lavender, and has the skin care functions of clearing away heat and toxic materials, cleaning skin, controlling oil content, removing freckles, whitening skin, removing wrinkles, tendering skin, removing under-eye dark circles, promoting regeneration and recovery of damaged tissues and the like. The lavender essential oil also has a calming effect on heart, can reduce hypertension and soothe palpitation, and is helpful for insomnia. The lavender essential oil can quickly permeate hair follicles to sterilize and resist bacteria, promote cell regeneration, recover skin connective tissues, balance the secretion of oil on the surface layer of the skin, relieve sensitive skin, astringe pores, supplement skin moisture, permanently protect the skin from the interference of whelks and acnes, and recover fine and smooth skin with zero pores and no pockmarks.
Silicone is a stable chemical substance, is non-toxic, non-irritating to the skin, lubricious and easy to apply, does not interfere with the normal function of the skin, does not contaminate the clothing, and has scar-clearing effects. According to the invention, the lavender essential oil and the silicone are compounded to supplement each other, so that the scar removing effect is enhanced. In addition, according to the invention, the insoluble lavender essential oil and the water-soluble lavender essential oil are compounded by using the propylene glycol, the polyethylene glycol 40, the tween 80 and the Arabic gum, and are uniformly dispersed in the aqueous solution with the assistance of the colloidal sulfur to prepare the liquid dressing, so that the liquid dressing is not greasy and is convenient to use.
The invention also uses polyhexamethylene guanidine as a bactericide to increase the bactericidal effect of the invention, and the polyhexamethylene guanidine is an environment-friendly high-molecular polymer bactericidal disinfectant and has broad bactericidal spectrum; has no irritation to skin and mucosa; the effective concentration is low; the action speed is high; the property is stable; excellent performance of being easily dissolved in water; can be used at normal temperature; long-term bacteriostasis without side effect; no corrosion; colorless and odorless; is nontoxic; the material is non-combustible, non-explosive and safe to use; the price is moderate; the transportation is convenient, and the bactericide is a superior bactericide.
In conclusion, the invention eliminates the defects of high irritation and clothes pollution of the sulfur in the process of treating skin diseases, reduces the adverse reaction of the sulfur, and is combined with the colloidal sulfur and the rhubarb total anthraquinone to be used as a sterilizing, insecticidal, hemostatic and antipruritic agent; the film forming property and biocompatibility of the acacia gum in the ultra-low molecular hyaluronic acid and the colloidal sulfur are applied to form a protective film on the surface of the skin to isolate the invasion of external substances; the application of ultra-low molecular hyaluronic acid and total anthraquinone of rhubarb as the wound healing promoting and skin repairing agent; lavender essential oil and silicone oil are used for preventing the generation of scars; therefore, the invention has the effects of sterilizing, killing parasites, stopping bleeding, relieving itching, promoting wound healing, promoting skin repair, preventing and removing scars, and is specially suitable for treating skin diseases caused by parasites and microorganisms, such as acne, skin toxoplasmosis, trichomonas vulvae pruritus, tinea manus and pedis, onychomycosis, tinea versicolor, psoriasis and the like.
Example 1
Preparation of rhubarb total anthraquinone
(1) Pulverizing radix et rhizoma Rhei, and sieving with 40 mesh sieve to obtain radix et rhizoma Rhei powder;
(2) adding calcium hydroxide, dissolving, and collecting supernatant;
(3) carrying out ultrasonic-assisted extraction on the rhubarb medicinal material powder for 2 times by using calcium hydroxide supernatant, wherein the first extraction is 40min, and the second extraction is 20min, and the mass ratio of the rhubarb medicinal material powder to the calcium hydroxide supernatant is 1: 5;
(4) filtering, mixing filtrates, ultrafiltering, and concentrating;
(5) adjusting the pH value to 3 with hydrochloric acid, precipitating, and filtering the precipitate;
(6) freeze drying the precipitate to obtain red rhubarb total anthraquinone powder;
(7) the purity of the total anthraquinone in rhubarb is detected to be 91.6 percent.
Preparation of colloidal sulfur liquid dressing
Colloidal sulfur liquid dressing formula table
Figure BDA0001922002700000111
(1) Weighing 10 parts of colloidal sulfur and 1 part of rhubarb total anthraquinone, dissolving in 40 parts of water, and dissolving by ultrasonic wave to obtain a solution a1；
(2) Weighing 1 part of ultra-low molecular hyaluronic acid and 0.5 part of ceramide, adding into 22.8 parts of water for dissolving, and then adding 0.2 part of polyhexamethylene guanidine, 5 parts of tween 80 and 1 part of polyethylene glycol 40 to obtain solution b1；
(3) Weighing 0.5 part of lavender essential oil and 8 parts of silicone, adding into 10 parts of propylene glycol for dilution, and uniformly mixing by ultrasonic waves to obtain a solution c1；
(4) Mixing the solution a1And c1Adding solution b1And (5) uniformly mixing the components by ultrasonic waves to obtain the colloidal sulfur liquid dressing.
The liquid dressing can be canned to prepare spray, has the advantages of killing parasite, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin, and is especially suitable for treating dermatogic diseases caused by parasite and microorganism, especially acne, rosacea, toxoplasmosis, trichomonas vulvae pruritus, tinea manus and pedis, tinea unguium, tinea versicolor, psoriasis, tinea capitis, seborrheic dermatitis, and neurodermatitis.
Example 2
Preparation of rhubarb total anthraquinone
(1) Pulverizing radix et rhizoma Rhei, and sieving with 40 mesh sieve to obtain radix et rhizoma Rhei powder;
(2) adding calcium hydroxide, dissolving, and collecting supernatant;
(3) carrying out ultrasonic-assisted extraction on the rhubarb medicinal material powder for 2 times by using calcium hydroxide supernatant, wherein the first extraction is 40min, and the second extraction is 20min, and the mass ratio of the rhubarb medicinal material powder to the calcium hydroxide supernatant is 1: 5;
(4) filtering, mixing filtrates, ultrafiltering, and concentrating;
(5) adjusting the pH value to 3 with hydrochloric acid, precipitating, and filtering the precipitate;
(6) freeze drying the precipitate to obtain red rhubarb total anthraquinone powder;
(7) the purity of the total anthraquinone in rhubarb is detected to be 91.6 percent.
Preparation of colloidal sulfur liquid dressing
Colloidal sulfur liquid dressing formula table
Figure BDA0001922002700000121
Figure BDA0001922002700000131
(1) Weighing 8 parts of colloidal sulfur and 1 part of total anthraquinone in rhubarb, dissolving the colloidal sulfur and the total anthraquinone in 40 parts of water, and dissolving the colloidal sulfur and the total anthraquinone in ultrasonic waves to obtain a solution a2；
(2) Weighing 1 part of ultra-low molecular hyaluronic acid and 0.5 part of ceramide, adding 23.3 parts of water for dissolving, and then adding 0.2 part of polyhexamethylene guanidine, 5 parts of tween 80 and 2 parts of polyethylene glycol 40 to obtain solution b2；
(3) Weighing 1 part of lavender essential oil and 8 parts of silicone, adding into 10 parts of propylene glycol for dilution, and uniformly mixing by ultrasonic waves to obtain a solution c2；
(4) Mixing the solution a2And c2Adding solution b2And (5) uniformly mixing the components by ultrasonic waves to obtain the colloidal sulfur liquid dressing.
The liquid dressing can be made into patch with soaked non-woven fabric, has the advantages of killing parasite, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin, and is specially used for treating dermatosis caused by parasite and microorganism, especially for treating acne and toxoplasmosis of skin.
Example 3
Preparation of rhubarb total anthraquinone
(1) Pulverizing radix et rhizoma Rhei, and sieving with 40 mesh sieve to obtain radix et rhizoma Rhei powder;
(2) adding calcium hydroxide, dissolving, and collecting supernatant;
(3) carrying out ultrasonic-assisted extraction on the rhubarb medicinal material powder for 2 times by using calcium hydroxide supernatant, wherein the first extraction is 40min, and the second extraction is 20min, and the mass ratio of the rhubarb medicinal material powder to the calcium hydroxide supernatant is 1: 5;
(4) filtering, mixing filtrates, ultrafiltering, and concentrating;
(5) adjusting the pH value to 3 with hydrochloric acid, precipitating, and filtering the precipitate;
(6) freeze drying the precipitate to obtain red rhubarb total anthraquinone powder;
(7) the purity of the total anthraquinone in rhubarb is detected to be 91.6 percent.
Preparation of colloidal sulfur liquid dressing
Colloidal sulfur liquid dressing formula table
Figure BDA0001922002700000141
(1) Weighing 10 parts of colloidal sulfur and 1 part of rhubarb total anthraquinone, dissolving in 40 parts of water, and dissolving by ultrasonic wave to obtain a solution a3；
(2) Weighing 1 part of ultra-low molecular hyaluronic acid and 0.5 part of ceramide, adding 21.3 parts of water for dissolving, and then adding 0.2 part of polyhexamethylene guanidine, 5 parts of tween 80 and 2 parts of polyethylene glycol 40 to obtain solution b3；
(3) Weighing 1 part of lavender essential oil and 8 parts of silicone, adding into 10 parts of propylene glycol for dilution, and uniformly mixing by ultrasonic waves to obtain a solution c3；
(4) Mixing the solution a3And c3Adding solution b3And (5) uniformly mixing the components by ultrasonic waves to obtain the colloidal sulfur liquid dressing.
The liquid dressing can be canned into a ball rolling device to prepare a ball rolling agent, has the advantages of killing insects, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin and the like, is specially used for treating skin diseases caused by parasites and microorganisms, and is particularly suitable for treating acne, tinea of feet and hands, sweat stains and psoriasis.
Example 4
Preparation of rhubarb total anthraquinone
(1) Pulverizing radix et rhizoma Rhei, and sieving with 40 mesh sieve to obtain radix et rhizoma Rhei powder;
(2) adding calcium hydroxide, dissolving, and collecting supernatant;
(3) carrying out ultrasonic-assisted extraction on the rhubarb medicinal material powder for 2 times by using calcium hydroxide supernatant, wherein the first extraction is 40min, and the second extraction is 20min, and the mass ratio of the rhubarb medicinal material powder to the calcium hydroxide supernatant is 1: 5;
(4) filtering, mixing filtrates, ultrafiltering, and concentrating;
(5) adjusting the pH value to 3 with hydrochloric acid, precipitating, and filtering the precipitate;
(6) freeze drying the precipitate to obtain red rhubarb total anthraquinone powder;
(7) the purity of the total anthraquinone in rhubarb is detected to be 91.6 percent.
Preparation of colloidal sulfur liquid dressing
Colloidal sulfur liquid dressing formula table
Figure BDA0001922002700000151
Figure BDA0001922002700000161
(1) Weighing 12 parts of colloidal sulfur and 1 part of rhubarb total anthraquinone, dissolving in 40 parts of water, and dissolving by ultrasonic wave to obtain a solution a4；
(2) Weighing 1 part of ultra-low molecular hyaluronic acid and 0.5 part of ceramide, adding 19.3 parts of water for dissolving, and then adding 0.2 part of polyhexamethylene guanidine, 5 parts of tween 80 and 2 parts of polyethylene glycol 40 to obtain solution b4；
(3) Weighing 1 part of lavender essential oil and 8 parts of silicone, adding into 10 parts of propylene glycol for dilution, and uniformly mixing by ultrasonic waves to obtain a solution c4；
(4) Mixing the solution a4And c4Adding solution b4And (5) uniformly mixing the components by ultrasonic waves to obtain the colloidal sulfur liquid dressing.
The liquid dressing can be canned into lotion, has the advantages of killing parasite, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin, and is specially used for treating dermatosis caused by parasite and microorganism, especially trichomonas vulvae pruritus.
Example 5
Preparation of rhubarb total anthraquinone
(1) Pulverizing radix et rhizoma Rhei, and sieving with 60 mesh sieve to obtain radix et rhizoma Rhei powder;
(2) adding calcium hydroxide, dissolving, and collecting supernatant;
(3) carrying out ultrasonic-assisted extraction on the rhubarb medicinal material powder for 2 times by using calcium hydroxide supernatant, wherein the first extraction is carried out for 60min, and the second extraction is carried out for 30min, wherein the mass ratio of the rhubarb medicinal material powder to the calcium hydroxide supernatant is 1: 4;
(4) filtering, mixing filtrates, ultrafiltering, and concentrating;
(5) adjusting pH to 3.5 with hydrochloric acid, precipitating, and filtering the precipitate;
(6) freeze drying the precipitate to obtain red rhubarb total anthraquinone powder;
(7) the purity of the total anthraquinone in rhubarb is detected to be 90.2 percent.
Preparation of colloidal sulfur liquid dressing
Colloidal sulfur liquid dressing formula table
Figure BDA0001922002700000171
(1) Weighing 8 parts of colloidal sulfur and 0.8 part of rhubarb total anthraquinone, dissolving in 50 parts of water, and dissolving by ultrasonic waves to obtain a solution a5；
(2) Weighing 1.2 parts of ultra-low molecular weight hyaluronic acid and 0.6 part of ceramide, adding into 28 parts of water for dissolving, and then adding 0.3 part of polyhexamethylene guanidine, 3 parts of tween 80 and 2 parts of polyethylene glycol 40 to obtain a solution b5；
(3) Weighing 1 part of lavender essential oil and 13 parts of silicone, adding the lavender essential oil and the silicone into 8 parts of propylene glycol for dilution, and uniformly mixing the mixture by ultrasonic waves to obtain a solution c5；
(4) Mixing the solution a5And c5Adding solution b5And (5) uniformly mixing the components by ultrasonic waves to obtain the colloidal sulfur liquid dressing.
The liquid dressing can be made into patch with soaked non-woven fabric, has the advantages of killing parasite, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin, and is specially used for treating dermatosis caused by parasite and microorganism, especially for treating acne and toxoplasmosis of skin.
Example 6
Preparation of rhubarb total anthraquinone
(1) Pulverizing radix et rhizoma Rhei, and sieving with 30 mesh sieve to obtain radix et rhizoma Rhei powder;
(2) adding calcium hydroxide, dissolving, and collecting supernatant;
(3) extracting radix et rhizoma Rhei medicinal material powder with calcium hydroxide supernatant for 120min for 1 time under the assistance of ultrasonic wave, wherein the mass ratio of radix et rhizoma Rhei medicinal material powder to calcium hydroxide supernatant is 1: 6;
(4) filtering, mixing filtrates, ultrafiltering, and concentrating;
(5) adjusting pH to 2.8 with hydrochloric acid, precipitating, and filtering the precipitate;
(6) freeze drying the precipitate to obtain red rhubarb total anthraquinone powder;
(7) the purity of the total anthraquinone in rhubarb is detected to be 83.3 percent.
Preparation of colloidal sulfur liquid dressing
Colloidal sulfur liquid dressing formula table
Figure BDA0001922002700000181
Figure BDA0001922002700000191
(1) Weighing 12 parts of colloidal sulfur and 1.2 parts of total anthraquinone in rhubarb, dissolving in 38 parts of water, and dissolving by ultrasonic wave to obtain a solution a6；
(2) Weighing 0.8 part of ultra-low molecular weight hyaluronic acid and 1.5 parts of ceramide, adding into 12 parts of water for dissolving, and then adding 0.4 part of polyhexamethylene guanidine, 2 parts of tween 80 and 2.5 parts of polyethylene glycol 40 to obtain a solution b6；
(3) Weighing 0.2 part of lavender essential oil and 5 parts of silicone, adding into 6 parts of propylene glycol for dilution, and uniformly mixing by ultrasonic waves to obtain a solution c6；
(4) Mixing the solution a6And c6Adding solution b6In the middle, ultrasonic wave is mixed evenly to obtain the colloidal sulfur liquid dressing。
The liquid dressing can be canned into a ball rolling device to prepare a ball rolling agent, has the advantages of killing insects, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin and the like, is specially used for treating skin diseases caused by parasites and microorganisms, and is particularly suitable for treating acne, tinea of feet and hands, sweat stains and psoriasis.
Example 7
Preparation of rhubarb total anthraquinone
(1) Pulverizing radix et rhizoma Rhei, and sieving with 50 mesh sieve to obtain radix et rhizoma Rhei powder;
(2) adding calcium hydroxide, dissolving, and collecting supernatant;
(3) carrying out ultrasonic-assisted extraction on the rhubarb medicinal material powder for 2 times by using calcium hydroxide supernatant, wherein the first extraction is carried out for 50min, and the second extraction is carried out for 25min, wherein the mass ratio of the rhubarb medicinal material powder to the calcium hydroxide supernatant is 1: 7;
(4) filtering, mixing filtrates, ultrafiltering, and concentrating;
(5) adjusting pH to 3.2 with hydrochloric acid, precipitating, and filtering the precipitate;
(6) freeze drying the precipitate to obtain red rhubarb total anthraquinone powder;
(7) the purity of the total anthraquinone in rhubarb is detected to be 87.9 percent.
Preparation of colloidal sulfur liquid dressing
Colloidal sulfur liquid dressing formula table
Figure BDA0001922002700000201
(1) Weighing 15 parts of colloidal sulfur and 3 parts of total anthraquinone in rhubarb, dissolving in 52 parts of water, and dissolving by ultrasonic wave to obtain a solution a7；
(2) Weighing 2.5 parts of ultra-low molecular weight hyaluronic acid and 2 parts of ceramide, adding into 28 parts of water for dissolving, and then adding 0.5 part of polyhexamethylene guanidine, 4 parts of tween 80 and 3 parts of polyethylene glycol 40 to obtain a solution b7；
(3) Weighing 0.3 part of lavender essential oil and 15 parts of silicone, adding into 9 parts of propylene glycol for dilution, and uniformly mixing by ultrasonic waves to obtain a solution c7；
(4) Mixing the solution a7And c7Adding solution b7And (5) uniformly mixing the components by ultrasonic waves to obtain the colloidal sulfur liquid dressing.
The liquid dressing can be canned into lotion, has the advantages of killing parasite, sterilizing, relieving itching, promoting wound healing, inhibiting scar formation, repairing and protecting skin, and is specially used for treating dermatosis caused by parasite and microorganism, especially trichomonas vulvae pruritus.

Claims (8)

1. The colloidal sulfur liquid dressing is characterized by comprising the following components in parts by weight:
0.5-15 parts of colloidal sulfur;
0.5-5 parts of total rhubarb anthraquinone;
39.5-84.9 parts of water;
the colloidal sulfur is sulfur particles prepared from sulfur and Arabic gum, the Arabic gum is coated outside the sulfur to form microcapsules, and the microcapsules can be uniformly distributed in water to form a colloidal solution; the mass ratio of the sulfur to the Arabic gum in the colloidal sulfur is 1: 2-5;
the colloidal sulfur liquid dressing further comprises: lavender essential oil, silicone, ultra-low molecular weight hyaluronic acid, ceramide, propylene glycol, tween 80, polyethylene glycol 40 and polyhexamethylene guanidine;
the preparation method of the rhubarb total anthraquinone comprises the following steps:
s1, pulverizing radix et rhizoma Rhei, and sieving;
s2, adding calcium hydroxide into water for dissolving, and taking supernatant for later use;
s3, extracting rhubarb medicinal material powder by using the calcium hydroxide supernatant;
s4, filtering, and performing ultrafiltration after filtering is completed;
s5, adjusting the pH to 2-4 by adopting an acidic substance, precipitating, and filtering the precipitate;
s6, freeze-drying the precipitate obtained in the step S5 to obtain the rhubarb total anthraquinone.
2. The colloidal sulfur liquid dressing as claimed in claim 1, which is characterized by comprising the following components in parts by weight:
0.5-10 parts of colloidal sulfur;
1-5 parts of total rhubarb anthraquinone;
49.5-80.4 parts of water.
3. The colloidal sulfur liquid dressing as claimed in claim 1, wherein the weight ratio of the colloidal sulfur to the total anthraquinone in rheum officinale is 8-12: 1.
4. the dressing of claim 1, wherein in step S3, ultrasonic-assisted extraction is adopted, and the mass ratio of the rhubarb medicinal material powder to the calcium hydroxide supernatant is 1: 3-10.
5. The colloidal sulfur liquid dressing of claim 1, further comprising the following components:
0.1-1 part of lavender essential oil
5-15 parts of silicone
1-3 parts of ultra-low molecular hyaluronic acid
0.5-3 parts of ceramide
5-10 parts of propylene glycol
Tween 802-5 parts
401-3 parts of polyethylene glycol
0.1-0.5 parts of polyhexamethylene guanidine.
6. A colloidal sulfur liquid dressing according to claim 5, further comprising the following components:
0.5-1 part of lavender essential oil
8-10 parts of silicone
1-3 parts of ultra-low molecular hyaluronic acid
0.5-3 parts of ceramide
5-10 parts of propylene glycol
Tween 802-5 parts
401-3 parts of polyethylene glycol
0.1-0.5 parts of polyhexamethylene guanidine.
7. The colloidal sulfur liquid dressing of claim 5, wherein the molecular weight of the ultra-low molecular hyaluronic acid is 3000-10000.
8. The preparation method of the colloidal sulfur liquid dressing according to any one of claims 1 to 7, which is characterized by comprising the following steps:
p1, weighing colloidal sulfur and total rhubarb anthraquinone, adding the colloidal sulfur and the total rhubarb anthraquinone into water, and dissolving the mixture by ultrasonic waves to obtain a solution a;
p2, weighing ultra-low molecular hyaluronic acid and ceramide, adding into water for dissolving, then adding polyhexamethylene guanidine, Tween 80 and polyethylene glycol 40, and dissolving to obtain a solution b;
p3, weighing lavender essential oil and silicone, adding propylene glycol for dilution, and mixing uniformly to obtain a solution c;
and P4, adding the solution a and the solution c into the solution b, and uniformly mixing to obtain the colloidal sulfur liquid dressing.
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