CN105148059A - Plant oil external liniment capable of repelling mosquitos and preparation method thereof - Google Patents
Plant oil external liniment capable of repelling mosquitos and preparation method thereof Download PDFInfo
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Abstract
The invention discloses plant oil external liniment capable of repelling mosquitos and a preparation method thereof. The plant oil external liniment comprises citronella oil, lavender essential oil, tea tree oil, folium artemisiae argyi oil, star anise oil, cinnamon oil, liquid paraffin and menthol. The plant oil external liniment has the advantages that the plant oil external liniment can prevent mosquito bites and treat skin inflammation caused by the mosquito bites; a large amount of experiments shows that the mosquito plant oil external liniment is good in mosquito repelling effect and good in curative effect on symptoms such as pain, itching, red and swollen skin and dermatitis caused by the mosquito bites; meanwhile, the other medicinal constituents of the plant oil external liniment have evident skin caring, inflammation diminishing, antibacterial and granulation promoting effects.
Description
Technical field
The present invention relates to a kind of vegetable oil biopharmaceutical composition for mosquito dispersing, specifically a kind of vegetable oil compound external-use liniment for mosquito dispersing.Various plants extract volatile oil in this preparation, nontoxic nonirritant, existing therapeutical effect, has skin-care effect again, and the antibacterial granulation promoting effect of antiinflammatory is simultaneously good especially, belongs to medical science pharmaceutical technology sectors.
Background technology
Summer and autumn, mostly be that mosquito enlivens period, this has brought many troubles, the erythema caused after mosquito bite gently then can be recovered voluntarily, heavy then make the blister in original dermatitis scratch brokenly unbearably owing to very itching then to cause wound circumference to grow a large amount of antibacterial, cause other skin disease, and permanent cicatrix can be left, bring great negative effect to patient.
All kinds of medication for driving mosquitoes now commercially sold, many employings chemical composition is made, not only there is certain side effect, and environment is also polluted, it, while reaching mosquito killing worm effect, also forms the injury to people, especially harmful effect is formed to the respiratory tract of people, and general mosquito killing worm effect is better, its side effect is also larger, therefore not easily uses in a large number.Picture is through conventional floral water, although be only made up of Chinese medicine and spice, certain effect is had to mosquito dispersing, but do not promote wound healing, effect that antiinflammatory is antibacterial, as some commercially available anti-inflammatory anti-itch ointment, although can treat the partial symptoms after mosquito bite, but do not have prevention mosquito bite, promote effect of wound healing and skin growth.
China Patent No. a kind of multi-effect mosquito-repellent liquid medicine that has been the disclosure of the invention of CN102018004A, mixed by diethyltoluamide, citronella oil, eucalyptus oil, tea tree oil, Pyrethrum vinegar, litsea cubeba oil six component spice, mosquito repellent time of the present invention is long, the effect there is sterilization simultaneously, sterilize, purifying air, but the cicatrix stayed after can not effectively curing mosquito bite.The China Patent No. one that has been the disclosure of the invention of CN102579288A can direct acting mosquito dispersing natural plant essential oil composition, be made up of Oleum lavandula angustifolia, Indian oil of verbena, basil oil, Flos Matricariae chamomillae oil, Oleum menthae, eucalyptus globolus oil, tea tree oil, lemongrass oil, thyme oil, glycerol, ethanol, this invention effectively can play mosquito-repelling function, but effective percentage is not high, and life-time service ethanol easily damages skin.China Patent No. a kind of be the disclosure of the invention of CN101233864 mosquito-repellent essential oil compositions and anophelifuge method, by Oleum Caryophylli, litsea cubeba oil, form by leaf oil, purebred Lignum cinnamomi camphorae leaf oil, thyme oil, citronella oil, Oleum Pelargonii Graveolentis, Oleum lavandula angustifolia, wintergreen oil, Oleum menthae, Oleum Cinnamomi, Cedar oil, Michelia leap oil, Rue oil., Oleum Rosae Rugosae, tea tree oil, these technical scheme raw material sources are complicated, cost is high, and anophelifuge aggregate efficiency is remarkable not as good as the present invention.
Summary of the invention
The invention provides a kind of vegetable oil compound external-use liniment for mosquito dispersing, using natural plant extracts volatile oil as principal agent composition, mosquito proof can bite, have again antibacterial, anti-inflammatory anti-itch, promote the effect of wound healing and skin growth.
A kind of vegetable oil compound medicine for mosquito dispersing of the present invention, it is characterized in that being made up by ratio of weight and the number of copies of following medicine:
Citronella oil 10-30 part, Herba Lysimachiae foenum-graeci quintessence oil 10-20 part, tea tree oil 10-25 part, Oleum Folium Artemisiae Argyi 0.8-2 part, star anise oil 0.6-1.8 part, Oleum Cinnamomi 0.4-1.5 part, liquid paraffin 110-135 part, Mentholum 20-45 part.
A kind of vegetable oil compound medicine for mosquito dispersing of the present invention is prepared from by the raw material of following optimum weight part proportioning:
Citronella oil 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 20 parts, tea tree oil 15 parts, Oleum Folium Artemisiae Argyi 1.5 parts, star anise oil 1 part, Oleum Cinnamomi 0.4 part, liquid paraffin 110 parts, Mentholum 35 parts.
The above-mentioned a kind of vegetable oil compound medicine for mosquito dispersing of the present invention makes the preparation method of externally applied liniment, comprises the following steps:
Mentholum and liquid paraffin are dissolved in water-bath, then adds other volatile oil successively in proportion, be placed on magnetic stirring apparatus and stir, whipping temp is 20-40 DEG C, and mixing speed is 30-50 rev/min, and mixing time is 1-3h, until clear, obtain product.
Vegetable oil compound medicine for mosquito dispersing of the present invention, other adjuvant such as solubilizing agent or nonaqueous solvent can be added and can be made into gel, ointment, spray, lotion, suppository etc. are for the disinfectant of skin and mucosa, pasteurization towelette, antiseptic gauze, the various sterile products such as adhesive bandage, can also the multi-form or object such as health and daily chemical products use.
using method: get appropriate quintessence oil at the palm of the hand, wipe medicine at skin or mosquito bite position uniformly, repeated massage is rubbed, to absorbing completely.Also can drip in collar, cuff, use as perfume bottom shoe pad.
In the natural plant volatile oil related in the present invention, monarch drug is citronella oil, star anise oil.Wherein the most important characteristic of citronella oil is exactly anthelmintic action, is the primary raw material of mosquito proof, can effectively alleviate headache, migraine and neuralgia, also has sterilization, antiinflammatory, relaxing muscles and tendons and activating QI and blood in the collateral, controls effect of wind syndrome of head, only stomachache; Star anise oil has antibacterial (gram positive bacteria: staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, gram negative bacteria: escherichia coli, bacillus subtilis, vibrio cholera and Bacillus typhi, Salmonella paratyphi, dysentery bacterium), antioxidation, analgesia, insecticidal action, modern medicine study shows that star anise oil also has leukocyte increasing and antihistamine effect, can be used as fragrant remedium corrigens and stomachic; Oleum Cinnamomi is ministerial drug, has fragrant stomach invigorating, the effects such as wind dispelling, also can be used for dispelling the wind and dampness pathogens and skin pruritus, has the effect strengthening monarch drug.Herba Lysimachiae foenum-graeci quintessence oil, tea tree oil, Oleum Folium Artemisiae Argyi are as adjuvant drug.Lavandula angustifolia effectively can improve scald, sunburn, eczema, chronic eczema, the skin of abscess, improves cicatrix, bacteria growing inhibiting, helps natural on-off cycles of hair growth, modern medicine study shows that lavandula angustifolia can also promote cell regeneration, Bergamot Mint Extract, improves insomnia, reduce hypertension, calm heart, gynecological and digestive problems, parasite killing, to purify air, but also purification of the mind, mood placating, alleviate indignation, centre of equilibrium is neural, problem such as conditioning gynecological and digestive system etc.; Tea tree oil has very strong antivirus action, can promote wound healing, treatment skin trauma, burn; Oleum Folium Artemisiae Argyi is antibacterial, antiviral, antiallergic, also has certain eliminating the phlegm, antitussive effect, and the drug effect of the monarch and his subjects strengthened by three medicines; The compound liniment that the present invention makes after said components being mixed, its effective ingredient is concentrated to produce synergism, compensate for the defect of one-component mosquito-repelling effect difference.
the present invention has following beneficial effect:
Using natural plant extracts volatile oil as principal agent composition, maintain bio-pharmaceutical multicomponent, the characteristic of many effects, have good mosquito-repelling effect, active constituents of medicine onset is rapid, and effect is remarkable; Percutaneous permeability of the present invention is good, and nonirritant not easily remains, do not need with other drug with the use of; Pathogenic bacterium not easily develop immunity to drugs, in addition, because main component of the present invention is pure natural plant ingredients, harmless to human body, can not cause environmental pollution; The present invention through clinical practice confirm citronella oil and other components composite after mosquito dispersing effective percentage reach more than 98%, and have skin-care effect concurrently, the good especially one that develops of the antibacterial granulation promoting effect of antiinflammatory can mosquito proof be bitten simultaneously, have again antibacterial, anti-inflammatory anti-itch, promotes the new bio pharmaceutical composition of wound healing and skin growth.Because main component of the present invention is pure natural plant ingredients, therefore there is the feature of no side effects, not only harmless to human body, can not environmental pollution be caused, and mosquito-repelling effect is remarkable.In addition, this medication for driving mosquitoes has certain fragrant, can drip in collar, cuff, uses bottom shoe pad as perfume.
Detailed description of the invention
To be illustrated further description the present invention by following examples, and do not limit the present invention in any way, under the prerequisite not deviating from technical solution of the present invention, any change that those of ordinary skill in the art made for the present invention easily realize or change all will fall within right of the present invention.
embodiment 1
Take citronella oil 20g, Herba Lysimachiae foenum-graeci quintessence oil 20g, tea tree oil 15g, Oleum Folium Artemisiae Argyi 1.5g, star anise oil 1g, Oleum Cinnamomi 0.4g, liquid paraffin 110g, Mentholum 35g.
preparation method: by 35g Mentholum and 110g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 40r/min, on the magnetic stirring apparatus that temperature is 30 DEG C, slowly add the Oleum Cinnamomi of 0.4g, stir 2h, the citronella oil of the Herba Lysimachiae foenum-graeci quintessence oil and 20g that add 20g immediately stirs 2h, last slowly adding successively remains other volatile oil, continues to stir until clear, gets product.
embodiment 2
Take citronella oil 15g, Herba Lysimachiae foenum-graeci quintessence oil 10g, tea tree oil 20g, Oleum Folium Artemisiae Argyi 1g, star anise oil 1.5g, Oleum Cinnamomi 0.6g, liquid paraffin 115g, Mentholum 20g.
preparation method: by 20g Mentholum and 115g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 30r/min, on the magnetic stirring apparatus that temperature is 25 DEG C, slowly add the Oleum Cinnamomi of 0.6g, stir 1h, the citronella oil of the Herba Lysimachiae foenum-graeci quintessence oil and 15g that add 10g immediately stirs 1h, last slowly adding successively remains other volatile oil, continues to stir until clear, gets product.
embodiment 3
Take citronella oil 10g, Herba Lysimachiae foenum-graeci quintessence oil 15g, tea tree oil 25g, Oleum Folium Artemisiae Argyi 2g, star anise oil 1.8g, Oleum Cinnamomi 1.5g, liquid paraffin 125g, Mentholum 45g.
preparation method: by 45g Mentholum and 125g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 30r/min, on the magnetic stirring apparatus that temperature is 20 DEG C, slowly add the Oleum Cinnamomi of 1.5g, stir 2.5h, the citronella oil of the Herba Lysimachiae foenum-graeci quintessence oil and 10g that add 15g immediately stirs 2.5h, last slowly adding successively remains other volatile oil, continues to stir until clear, gets product.
embodiment 4
Take citronella oil 30g, Herba Lysimachiae foenum-graeci quintessence oil 12g, tea tree oil 10g, Oleum Folium Artemisiae Argyi 0.8g, star anise oil 1g, Oleum Cinnamomi 1g, liquid paraffin 135g, Mentholum 40g.
preparation method: by 40g Mentholum and 135g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 40r/min, on the magnetic stirring apparatus that temperature is 40 DEG C, slowly add the Oleum Cinnamomi of 1g, stir 3h, the citronella oil of the Herba Lysimachiae foenum-graeci quintessence oil and 30g that add 12g immediately stirs 3h, last slowly adding successively remains other volatile oil, continues to stir until clear, gets product.
embodiment 5
Take citronella oil 25g, Herba Lysimachiae foenum-graeci quintessence oil 18g, tea tree oil 12g, Oleum Folium Artemisiae Argyi 1.2g, star anise oil 0.8g, Oleum Cinnamomi 1.2g, liquid paraffin 120g, Mentholum 30g.
preparation method: by 30g Mentholum and 120g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 40r/min, on the magnetic stirring apparatus that temperature is 20 DEG C, slowly add the Oleum Cinnamomi of 1.2g, stir 2h, the citronella oil of the Herba Lysimachiae foenum-graeci quintessence oil and 25g that add 18g immediately stirs 2h, last slowly adding successively remains other volatile oil, continues to stir until clear, gets product.
The present invention is through testing for many years; for the impact on 60 routine mosquito bite patients and scuffing wounds in mice healing state; a kind of vegetable oil compound external-use liniment for mosquito dispersing made by the present invention is when treating mosquito bite; that embrocates beginning onset in latter 2 minutes accounts for 98%, substantially cures in 40 minutes; Process observation scratches mice and scalds position Wound healing rate and wound healing time by experiment.Group is model group (not to any medicine), embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, matched group 1(multi-effect mosquito-repellent liquid medicine, the patent No. is CN102018004A), matched group 2(mono-kind can direct acting mosquito dispersing natural plant essential oil composition, the patent No. is CN102579288A), matched group 3(mosquito-repellent essential oil compositions and anophelifuge method, the patent No. is CN101233864).
Be below curative effect form:
60 routine mosquito bite patient curative effect forms
100 routine skin scald wounds healing rate and wound healing times
Experimental result shows, the present invention not only has good mosquito proof and bites effect, but also contribute to very much the healing of skin wound, Be very effective is better than matched group 1(multi-effect mosquito-repellent liquid medicine, the patent No. is CN102018004A), matched group 2(mono-kind can direct acting mosquito dispersing natural plant essential oil composition, the patent No. is CN102579288A), matched group 3(mosquito-repellent essential oil compositions and anophelifuge method, the patent No. is CN101233864).
Model case
Case 1. Zhang, man, 42 years old, in January, 2009 caused fire because of smoking in bed in bed, all will burn above the waist, and use this medicine (embodiment 1) after 20 days, wound healing, pay a return visit after 1 year, its scarless wound.
Case 2. Wang, man, 15 years old, live Yang Du village, the Tianmen City south of a city, Hubei Province, on May 20th, 2009, right shoulder was scalded accidentally, wound weight.After using this medicine (embodiment 2) treatment in 7 days, the wound of Wang has grown new skin, wound healing.Its scarless wound is checked after three months.
Case 3. Liu so-and-so, man, 12 years old, is accidentally poured in boiled water basin when within 2008, May 20 is because playing noisy and causes back large area to scald, skin of back large area removes when helping his de-cotton dress by its household subsequently, and after treating 10 days with this medicine (embodiment 3), wound is healed entirely.After three months pay a return visit, wound without dross, without cicatrix.
Case 4. Chen, man, 49 years old, in April, 2008, a careless lower limb was strayed into doline, and shank and foot's skin are all by the decortication of lime water burn, and after using this medicine (embodiment 4) to treat 8 days, skin is lived again, at present without any cicatrix.
Case 5. Lee so-and-so, man, 46 years old, in August, 2008, having a shower, boiled water work as cold water by mistiming, so scald head, face and chest, through use this medicine (embodiment 1) treatment 7 days after wound healing, check its wound after half a year, wound is without dross, without cicatrix.
Case 6. urges certain, 5 years old boy, and in the first month of the lunar year, 2009, both feet are scalded accidentally, through using this medicine (embodiment 2), complete through treatment in 8 days, at present without any cicatrix.
Case 7. king so-and-so, man, 33 years old, on October 8th, 2008 when blocked shot, because of add ethanol time accidentally by face, chest, abdominal part and hand large-area burns, entirely heal after using this medicine (embodiment 1) to give meticulous treatment 10 days, pay a return visit after 1 year, its injury is without dross, without cicatrix.
Case 8. Chen, female, 19 years old, in August, 2008, because household is careless, cause its foot to scald with boiled water, after institute of traditional Chinese medicine treats several days, sticking appears in toe part, introduce by friend and use this medicine (embodiment 2) treatment, wound healing after 8 days, paid a return visit after 1 year, and injury is without dross, without cicatrix.
Case 9. Cao, female, 17 years old, morning on March 25th, 2009, when holding boiled oil cauldron, was scalded face, cervical region and left arm by large area accidentally, and through continuous with this medicine (embodiment 1) after 7 hours, elimination of swelling and ache, wound, not at bleeding, heals after 9 days completely.At present without any cicatrix.
Case 10. Ma, female, 30 years old, in February, 2012 caused facial rats after severe scald burn because pressure cooker explodes, and fully recover after using this medicine (embodiment 3) to treat 10 days, face does not stay cicatrix.
Case 11. Lu, man, 30 years old, in October, 2010 kicked down thermos flask accidentally, left sufficient face is burned, the blister that scald face differs in size as seen, severe pain, punctures the blister at empyrosis place with aseptic syringe needle, the whole damage surface of normal saline flushing, wipe dry injury with Aseptic sterilisation Cotton Gossypii, fully recover, without cicatrix after using this medicine (embodiment 1) to smear 3 times.
in order to check medicine life-time service of the present invention whether can cause the phenomenon such as skin allergy, redness, carried out skin irritation test to it, method is as follows:
Adopt repeatedly intact skin irritant test method, select that 5 skin is intact, heavily about 4kg New Zealand white rabbit, 24h before test, slough the hair of each about 3cm × 3cm in its spinal column both sides, back, next day, by the compound external-use liniment of the embodiment 1 of preparation, embodiment 2, embodiment 3, embodiment 4, embodiment 5, is applied in skin of unhairing surface, side, covers 2 layers of sterile gauze, and use non-stimulated immobilization with adhesive tape, opposite side is using the substrate 1ml of preparation as blank.Thing of applying ointment or plaster is removed, with water cleaning removing residue after 4h.Smear every day once, smear 14d continuously.Observe local skin reaction respectively at 24h after removal tested material, carry out irritant reaction scoring.
skin Irritation Test result:
Adopt repeatedly intact skin irritant test method, white rabbit is planted to 5 New Zealand and tests, to detect the vegetable oil compound external-use liniment of embodiment 1 ~ 5 mosquito dispersing prepared by the present invention to the stimulation of laboratory animal skin and intensity.Respectively at observing the local skin reaction of test rabbits spinal column both sides after 24h, observed result is for test rabbit both sides skin is all without red and swollen and erythema, and scoring is 0, and skin irritation strength grading is nonirritant rank.
Above-mentioned explanation is not limitation of the present invention, and the present invention is not limited to above-mentioned example, those skilled in the art, and in essential scope of the present invention, the change made, change, interpolation or replacement, all should belong to protection scope of the present invention.
Claims (4)
1., for a vegetable oil compound medicine for mosquito dispersing, it is characterized in that being made up by ratio of weight and the number of copies of following medicine:
Citronella oil 10-30 part, Herba Lysimachiae foenum-graeci quintessence oil 10-20 part, tea tree oil 10-25 part, Oleum Folium Artemisiae Argyi 0.8-2 part, star anise oil 0.6-1.8 part, Oleum Cinnamomi 0.4-1.5 part, liquid paraffin 110-135 part, Mentholum 20-45 part.
2. a kind of vegetable oil compound medicine for mosquito dispersing according to claim 1 is prepared from by the raw material of following optimum weight part proportioning:
Citronella oil 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 20 parts, tea tree oil 15 parts, Oleum Folium Artemisiae Argyi 1.5 parts, star anise oil 1 part, Oleum Cinnamomi 0.4 part, liquid paraffin 110 parts, Mentholum 35 parts.
3. be made up the preparation method of externally applied liniment of a kind of vegetable oil compound medicine for mosquito dispersing described in claim 1 or 2, comprise the following steps:
Mentholum and liquid paraffin are dissolved in water-bath, then other volatile oil in claim 1 or 2 is added in proportion successively, be placed on magnetic stirring apparatus and stir, whipping temp is 20-40 DEG C, mixing speed is 30-50 rev/min, mixing time is 1-3h, until clear, obtains product.
4. the vegetable oil compound medicine for mosquito dispersing according to claim 1, other adjuvant such as solubilizing agent or nonaqueous solvent can be added and can be made into gel, ointment, spray, lotion, suppository etc. are for the disinfectant of skin and mucosa, pasteurization towelette, antiseptic gauze, the various sterile products such as adhesive bandage, can also the multi-form or object such as health and daily chemical products use.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106135310A (en) * | 2016-06-25 | 2016-11-23 | 广西柳州昊邦日化有限公司 | Mosquito expelling plaster |
| CN106214928A (en) * | 2016-08-23 | 2016-12-14 | 刘道鹏 | Mosquito-proof liquid medicine |
| CN107510597A (en) * | 2017-08-16 | 2017-12-26 | 上海中医药大学附属曙光医院 | A kind of simulating Zusanli point and the annulus with mosquito repellent function and its application |
| CN108542857A (en) * | 2018-04-26 | 2018-09-18 | 佛山市芊茹化妆品有限公司 | A kind of wet tissue for mosquito itch of releiving |
| CN111920911A (en) * | 2020-07-08 | 2020-11-13 | 江苏正大清江制药有限公司 | Mosquito-proof disinfectant and preparation method thereof |
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| CN101837082A (en) * | 2010-03-23 | 2010-09-22 | 胡立发 | Chinese preparation for treating burn without leaving scar |
| CN103181699A (en) * | 2011-12-28 | 2013-07-03 | 南通玺运贸易有限公司 | Mosquito-preventing cool pillow |
| CN103623009A (en) * | 2013-12-11 | 2014-03-12 | 周玉红 | Traditional Chinese medicine for treating superficial second-degree burns and scalds and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101837082A (en) * | 2010-03-23 | 2010-09-22 | 胡立发 | Chinese preparation for treating burn without leaving scar |
| CN103181699A (en) * | 2011-12-28 | 2013-07-03 | 南通玺运贸易有限公司 | Mosquito-preventing cool pillow |
| CN103623009A (en) * | 2013-12-11 | 2014-03-12 | 周玉红 | Traditional Chinese medicine for treating superficial second-degree burns and scalds and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106135310A (en) * | 2016-06-25 | 2016-11-23 | 广西柳州昊邦日化有限公司 | Mosquito expelling plaster |
| CN106214928A (en) * | 2016-08-23 | 2016-12-14 | 刘道鹏 | Mosquito-proof liquid medicine |
| CN107510597A (en) * | 2017-08-16 | 2017-12-26 | 上海中医药大学附属曙光医院 | A kind of simulating Zusanli point and the annulus with mosquito repellent function and its application |
| CN108542857A (en) * | 2018-04-26 | 2018-09-18 | 佛山市芊茹化妆品有限公司 | A kind of wet tissue for mosquito itch of releiving |
| CN111920911A (en) * | 2020-07-08 | 2020-11-13 | 江苏正大清江制药有限公司 | Mosquito-proof disinfectant and preparation method thereof |
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Application publication date: 20151216 |