CN105233271B - A kind of anti-scar salamander collagen burn cream and preparation method thereof - Google Patents
A kind of anti-scar salamander collagen burn cream and preparation method thereof Download PDFInfo
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 27
- 108010035532 Collagen Proteins 0.000 title claims abstract description 27
- 229920001436 collagen Polymers 0.000 title claims abstract description 27
- 241000269333 Caudata Species 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000006071 cream Substances 0.000 title claims 3
- 239000002674 ointment Substances 0.000 claims abstract description 33
- 239000002994 raw material Substances 0.000 claims abstract description 17
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 14
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940116229 borneol Drugs 0.000 claims abstract description 14
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 14
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 14
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- 240000004980 Rheum officinale Species 0.000 claims 1
- 235000008081 Rheum officinale Nutrition 0.000 claims 1
- 241000037740 Coptis chinensis Species 0.000 abstract description 6
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Abstract
一种防疤鲵皮胶原蛋白烧伤膏及其制备方法，涉及一种烧伤膏，先按下述原料配比取各原料：鲵皮胶原蛋白5~15g、大鲵鲵油5~15ml、芝麻油35~45ml、蜂蜡10~20g、三黄30~40g和冰片3~5g，所述的三黄由重量比为1:1:1的黄连、黄柏和大黄组成；将三黄和冰片均粉碎成粉末状，备用；首先将蜂蜡融化，然后加入芝麻油和三黄粉，100‑105℃下混合熬制15～20min后，过滤，取液体；待液体温度降至室温后，加入大鲵鲵油和冰片粉，然后置于4‑10℃温度下；待液体温度下降至4‑10℃时加入鲵皮胶原蛋白，搅拌混匀，最后加凡士林调制成一定黏稠度的药膏，即得产品。本发明的烧伤膏能够促进烧烫伤创面的快速愈合，提高烧烫伤创面皮肤的恢复效果，防止留疤痕。An anti-scar salamander skin collagen burn ointment and a preparation method thereof, relating to a burn ointment. Firstly, the raw materials are obtained according to the following ratio of raw materials: 5~15g of salamander skin collagen, 5~15ml of giant salamander salamander oil, and 35~5ml of sesame oil. 45ml, 10-20g of beeswax, 30-40g of three yellows and 3-5g of borneol, the three yellows are composed of Coptis chinensis, Phellodendron cortex and rhubarb in a weight ratio of 1:1:1; the three yellows and borneol are pulverized into powder , set aside; first melt the beeswax, then add sesame oil and three yellow powder, mix and boil at 100-105°C for 15-20 minutes, filter, and take the liquid; after the temperature of the liquid drops to room temperature, add giant salamander oil and borneol powder, and then Put it at a temperature of 4-10°C; when the temperature of the liquid drops to 4-10°C, add salamander skin collagen, stir and mix well, and finally add Vaseline to make an ointment with a certain consistency to obtain the product. The burn ointment of the invention can promote the rapid healing of the burn wound, improve the skin recovery effect of the burn wound, and prevent scarring.
Description
技术领域technical field
本发明涉及一种烧伤膏及其制备方法，具体涉及一种防疤鲵皮胶原蛋白烧伤膏及其制备方法。The invention relates to a burn ointment and a preparation method thereof, in particular to an anti-scar salamander skin collagen burn ointment and a preparation method thereof.
背景技术Background technique
据统计，我国每年因意外伤害的死亡人数中，烧伤仅次于交通事故，排在第二位，而且在交通事故伤害中也有大量伤员被烧伤。烧伤不当的处理往往导致患者留下疤痕，烧伤疤痕不仅有损容颜，还会影响相关组织或器官的生理功能，如烧伤疤痕在口处影响进食，在眼或睑外影响视力，在鼻孔附近影响呼吸等。所以尽早祛除烧伤疤痕才能保证我们健康生活。现在有些医院已有相关的消除疤痕的方法，但都是通过一些临床修复祛疤手术实现，比较复杂，而且费用较高，所以最好的方法还是烫伤后及时用药，从最初做好防范，防止留疤。According to statistics, in my country's annual death toll due to accidental injuries, burns rank second only to traffic accidents, and a large number of wounded are also burned in traffic accidents. Improper treatment of burns often leads to scars left by patients. Burn scars not only damage the appearance, but also affect the physiological functions of related tissues or organs. For example, burn scars affect eating at the mouth, affect vision outside the eyes or eyelids, and affect Breathe etc. Therefore, removing burn scars as soon as possible can ensure our healthy life. Now some hospitals have relevant methods to eliminate scars, but they are all realized through some clinical repair and scar removal operations, which are more complicated and expensive, so the best way is to take medicine in time after the burn, and take precautions from the beginning leave scars.
现有的烧伤药膏成分主要都是一些动物油、中药等，只能起到杀菌解毒、活血化淤、去腐生肌、止血止痛等功效，却没办法帮助修复皮肤、防止留疤。基于此，本发明提供一种防疤鲵皮胶原蛋白烧伤膏及其制备方法。The existing burn ointments are mainly composed of some animal oils and traditional Chinese medicines, etc., which can only play a role in sterilization and detoxification, promoting blood circulation and removing stasis, removing putrefaction and promoting muscle growth, stopping bleeding and relieving pain, but cannot help repair the skin and prevent scarring. Based on this, the present invention provides an anti-scar salamander skin collagen burn ointment and a preparation method thereof.
发明内容Contents of the invention
本发明的目的是提供一种防疤鲵皮胶原蛋白烧伤膏及其制备方法，以促进烧烫伤创面的快速愈合，提高烧烫伤创面皮肤的恢复效果，防止留疤痕。The object of the present invention is to provide an anti-scar salamander skin collagen burn ointment and a preparation method thereof, so as to promote the rapid healing of burn wounds, improve the recovery effect of burn wound skin, and prevent scarring.
为实现上述目的，本发明的技术方案是：一种防疤鲵皮胶原蛋白烧伤膏，其是由下述原料配比的鲵皮胶原蛋白5~15g、大鲵鲵油5~15ml、芝麻油35~45ml、蜂蜡10~20g、三黄30~40g和冰片3~5g，以及外加的将上述原料调制成具有一定黏稠度药膏的凡士林组成；所述的三黄由重量比为1:1:1的黄连、黄柏和大黄组成。其中，按上述原料配比，所需凡士林为10~15g。In order to achieve the above object, the technical solution of the present invention is: a kind of anti-scar salamander skin collagen burn ointment, it is by the salamander skin collagen 5～15g of following raw material ratio, giant salamander oil 5～15ml, sesame oil 35～ 45ml, 10-20g of beeswax, 30-40g of Sanhuang and 3-5g of borneol, and additional vaseline which is prepared from the above raw materials into ointment with a certain viscosity; Composition of Coptis chinensis, Cortex Phellodendron and Rhubarb. Wherein, according to the above raw material ratio, the required vaseline is 10-15g.
所述的一种防疤鲵皮胶原蛋白烧伤膏的制备方法，包括如下步骤：The preparation method of described a kind of anti-scar salamander skin collagen burn ointment, comprises the steps:
（1）、按上述原料配比取各原料，将三黄和冰片均粉碎成粉末状，备用；(1) Take each raw material according to the ratio of the above raw materials, grind the Sanhuang and borneol into powder, and set aside;
（2）、将蜂蜡融化，然后加入芝麻油和三黄粉，100-105℃下混合熬制15～20min后，过滤，取液体；(2) Melt the beeswax, then add sesame oil and three yellow powder, mix and boil at 100-105°C for 15-20 minutes, filter, and take the liquid;
（3）、待液体温度降至室温后，加入大鲵鲵油和冰片粉，然后置于4-10℃温度下；(3) After the temperature of the liquid drops to room temperature, add giant salamander oil and borneol powder, and then place it at a temperature of 4-10°C;
（4）、待液体温度下降至4-10℃时加入鲵皮胶原蛋白，搅拌混匀，最后加凡士林调制成一定黏稠度的药膏，即得产品。(4) When the temperature of the liquid drops to 4-10°C, add salamander skin collagen, stir and mix well, and finally add vaseline to make a certain viscous ointment to obtain the product.
正常的皮肤对自然界中的紫外线具有防护阻挡、保护皮肤深层细胞免受紫外线伤害的作用，而烧伤后的皮肤深层细胞暴露在外，在紫外线的照射下易发生感染。本发明烧伤膏中的大鲵鲵皮胶原蛋白能够吸收紫外光，使烧烫伤创面处暴露在外的皮肤深层细胞免受紫外光的伤害，减少创面感染，促进伤口愈合。另外，经分析可知，鲵皮胶原蛋白包括多种人体必需的氨基酸，这更有利于促进烧烫伤口的愈合。Normal skin has the function of protecting against ultraviolet rays in nature and protecting deep skin cells from ultraviolet rays, while deep skin cells after burns are exposed and prone to infection under ultraviolet irradiation. The giant salamander skin collagen in the burn ointment of the present invention can absorb ultraviolet light, so that the exposed skin deep layer cells at the burn wound can be protected from ultraviolet light damage, reduce wound infection, and promote wound healing. In addition, analysis shows that salamander skin collagen contains a variety of essential amino acids, which is more conducive to promoting the healing of burns and scalds.
大鲵鲵油成分能够抑制创面组织一氧化氮的产生，从而减少创面炎症细胞因子的释放，并发挥抑菌活性，参与和促进创面愈合。The components of giant salamander oil can inhibit the production of nitric oxide in wound tissue, thereby reducing the release of wound inflammatory cytokines, exerting antibacterial activity, and participating in and promoting wound healing.
凡士林能在肌肤表面形成一道保护膜，使皮肤的水分不易蒸发散失，阻挡了来自空气中的细菌和皮肤接触，从而降低了感染的可能性。而且它极不溶于水，可长久附着在皮肤上，因此具有很好的保湿效果，使伤口部位的皮肤组织保持最佳状态，加速皮肤自身的修复能力。Vaseline can form a protective film on the surface of the skin, so that the moisture of the skin is not easy to evaporate and lose, and it blocks the bacteria from the air from contacting the skin, thereby reducing the possibility of infection. Moreover, it is extremely insoluble in water and can be attached to the skin for a long time, so it has a good moisturizing effect, keeps the skin tissue at the wound site in an optimal state, and accelerates the skin's own repair ability.
有益效果：Beneficial effect:
本发明的烧伤膏与市场上现有的烧伤药相比，具有伤口愈合快（7天左右）、不留疤痕的特殊功效。Compared with the existing burn medicines on the market, the burn ointment of the present invention has the special effects of fast wound healing (about 7 days) and no scars.
本发明的烧伤膏对伤口有清凉麻痹作用，能够减少患者的疼痛。The burn ointment of the invention has cooling and paralyzing effects on wounds, and can reduce pain of patients.
本发明的烧伤膏能够使烫烧伤创面恢复的皮肤保持光滑，增强皮肤弹性，防止皮肤干燥，兼有护肤作用。The burn ointment of the invention can keep the recovered skin of scald burn wound smooth, enhance skin elasticity, prevent skin dryness, and have the function of skin care.
本发明的烧伤膏以鲵皮胶原蛋白为主要原料，与大鲵油、芝麻油、冰片、凡士林、三黄和蜂蜡中药物质混合调配而成，所有原料都是纯天然的，对皮肤无副作用。The burn ointment of the present invention uses salamander skin collagen as the main raw material, and is prepared by mixing giant salamander oil, sesame oil, borneol, vaseline, sanhuang and beeswax traditional Chinese medicine substances. All raw materials are pure natural and have no side effects on the skin.
本发明的烧伤膏适用于皮肤烫伤、烧伤患者，尤其对一度至浅二度烧伤、烫伤效果更好。The burn ointment of the present invention is suitable for skin scalds and burn patients, especially for first-degree to superficial second-degree burns and scalds.
具体实施方式Detailed ways
本发明以下四个实施例的配方均是按照前文所述的制备方法制备的。The formulations of the following four examples of the present invention are all prepared according to the preparation method described above.
实施例1Example 1
一种防疤鲵皮胶原蛋白烧伤膏，其是由下述原料配比的鲵皮胶原蛋白5g、大鲵鲵油10ml、芝麻油35ml、蜂蜡20g、三黄30g和冰片5g，以及外加的将上述原料调制成具有一定黏稠度药膏的凡士林组成；所述的三黄由重量比为1:1:1的黄连、黄柏和大黄组成，外加的凡士林为10g。An anti-scar salamander skin collagen burn ointment, which is composed of 5g of salamander skin collagen, 10ml of giant salamander salamander oil, 35ml of sesame oil, 20g of beeswax, 30g of Sanhuang 30g and 5g of borneol, and the above-mentioned raw materials added It is composed of vaseline prepared into an ointment with a certain viscosity; the three yellows are composed of Coptis chinensis, cortex cortex and rhubarb in a weight ratio of 1:1:1, and 10g of vaseline is added.
实施例2Example 2
一种防疤鲵皮胶原蛋白烧伤膏，其是由下述原料配比的鲵皮胶原蛋白10g、大鲵鲵油10ml、芝麻油40ml、蜂蜡15g、三黄35g和冰片3.9g，以及外加的将上述原料调制成具有一定黏稠度药膏的凡士林组成；所述的三黄由重量比为1:1:1的黄连、黄柏和大黄组成，外加的凡士林为12g。An anti-scar salamander collagen burn ointment, which is composed of salamander skin collagen 10g, giant salamander salamander oil 10ml, sesame oil 40ml, beeswax 15g, Sanhuang 35g and borneol 3.9g by the following raw material ratio, and the above-mentioned The raw materials are made of petroleum jelly with a certain consistency ointment; the three yellows are composed of Coptis chinensis, cortex cortex and rhubarb in a weight ratio of 1:1:1, and 12g of petroleum jelly is added.
实施例3Example 3
一种防疤鲵皮胶原蛋白烧伤膏，其是由下述原料配比的鲵皮胶原蛋白15g、大鲵鲵油5ml、芝麻油45ml、蜂蜡10g、三黄35g和冰片3g，以及外加的将上述原料调制成具有一定黏稠度药膏的凡士林组成；所述的三黄由重量比为1:1:1的黄连、黄柏和大黄组成，外加的凡士林为15g。An anti-scar salamander skin collagen burn ointment, which is composed of 15g of salamander skin collagen, 5ml of giant salamander salamander oil, 45ml of sesame oil, 10g of beeswax, 35g of Sanhuang 35g and 3g of borneol, and the above-mentioned raw materials added It is composed of petrolatum prepared into an ointment with a certain consistency; the three yellows are composed of Coptis chinensis, Phellodendron cortex and rhubarb in a weight ratio of 1:1:1, and 15g of petrolatum is added.
实施例4Example 4
一种防疤鲵皮胶原蛋白烧伤膏，其是由下述原料配比的鲵皮胶原蛋白10g、大鲵鲵油5ml、芝麻油35ml、蜂蜡10g、三黄40g和冰片4g，以及外加的将上述原料调制成具有一定黏稠度药膏的凡士林组成；所述的三黄由重量比为1:1:1的黄连、黄柏和大黄组成，外加的凡士林为12g。An anti-scar salamander skin collagen burn ointment, which is composed of 10g of salamander skin collagen, 5ml of giant salamander salamander oil, 35ml of sesame oil, 10g of beeswax, 40g of Sanhuang and 4g of borneol, and the above-mentioned raw materials added The vaseline prepared into an ointment with a certain consistency; the three yellows are composed of Coptis chinensis, cortex cortex and rhubarb in a weight ratio of 1:1:1, and the added vaseline is 12g.
药性实验Drug experiment
以大鼠为实验动物，在大鼠皮肤表面形成浅二度烧伤，创面面积为0.7cm2。Rats are used as experimental animals, and superficial second-degree burns are formed on the skin surface of the rats, with a wound area of 0.7cm 2 .
给药方法：将大鼠烧伤部位用清水冲洗1--2min，再用酒精消毒，之后取适量药膏均匀涂抹在大鼠烧伤的部位，覆盖整个受伤部位即可（厚度薄于1mm），注意伤口卫生。每隔12h更换新药，每次换药前，须将残留在创面上的药物及液化物拭去，并用酒精消毒，持续用药直至恢复。Administration method: Rinse the burnt part of the rat with water for 1-2 minutes, then disinfect with alcohol, then take an appropriate amount of ointment and apply it evenly on the burned part of the rat, covering the entire injured part (thinner than 1mm), pay attention to the wound health. Change the new medicine every 12 hours. Before changing the medicine, the medicine and liquefied substance left on the wound must be wiped off, disinfected with alcohol, and continue to use the medicine until recovery.
实验组：采用本发明的药膏，按上述给药方法对大鼠烧伤部位进行给药治疗，时间以7天为限，每隔一天对大鼠烧伤部位的创面大小进行测量记录。Experimental group: using the ointment of the present invention, according to the above-mentioned administration method, the burn site of rats was administered and treated, and the time was limited to 7 days, and the wound size of the burn site of rats was measured and recorded every other day.
对照组：采用市面上普通的烧伤膏，按上述给药方法对大鼠烧伤部位进行给药治疗，时间以7天为限，每隔一天对大鼠烧伤部位的创面大小进行测量记录。Control group: use the common burn ointment on the market to treat the burns of rats according to the above-mentioned administration method, and the time is limited to 7 days, and the wound size of the burns of rats is measured and recorded every other day.
实验结果：Experimental results:
结果显示：实验组采用本发明的防疤鲵皮胶原蛋白烧伤膏对大鼠烧伤创面进行给药治疗，给药第7天创面即可痊愈，且没有留下疤痕。The results showed that: the experimental group used the anti-scar salamander skin collagen burn ointment of the present invention to treat the burn wounds of rats, and the wounds were healed on the 7th day after administration without leaving scars.
对照组采用市面上现有的普通烧伤膏进行治疗，给药第7天大鼠烧伤创面的面积为0.2 cm2，并没有痊愈；对照组采用普通烧伤膏继续给药3天后痊愈，痊愈后留下一0.5mm长的疤痕隆起。The control group was treated with the existing common burn ointment on the market. On the 7th day of administration, the burn wound area of the rats was 0.2 cm 2 , and the rats were not healed; The next 0.5mm long scar is elevated.
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| CN101648014A (en) * | 2008-08-13 | 2010-02-17 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating skin injury and ulcer and application thereof |
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