CN105233271A - Anti-scaring andrias skin collagen burn cream and preparation method thereof - Google Patents
Anti-scaring andrias skin collagen burn cream and preparation method thereof Download PDFInfo
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- CN105233271A CN105233271A CN201510798413.3A CN201510798413A CN105233271A CN 105233271 A CN105233271 A CN 105233271A CN 201510798413 A CN201510798413 A CN 201510798413A CN 105233271 A CN105233271 A CN 105233271A
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Abstract
The invention provides anti-scaring andrias skin collagen burn cream and a preparation method thereof and relates to burn cream. The preparation method comprises the steps of first taking raw materials according to the following raw material ratio: 5-15 g of andrias skin collagen, 5-15 ml of andrias oil, 35-45 ml of sesame oil, 10-20 g of beeswax, 30-40 g of sanhuang and 3-5 g of borneol, wherein the sanhuang is composed of coptis chinensis, cortex phellodendri and rhubarb according to a weight ratio of 1:1:1; smashing the sanhuang and borneol into powder to be reserved; first melting the beeswax and then adding the sesame oil and sanhuang powder, performing mixed boiling for 15-20 min at 100-105 DEG C, performing filtering, and taking liquid; when the liquid temperature is lowered to room temperature, adding the andrias oil and borneol powder, and placing the liquid in the environment at 4-10 DEG C; when the liquid temperature is reduced to 4-10 DEG C, adding the andrias skin collagen, performing stirring evenly, finally adding vaseline to obtain an ointment having a certain stickness, and obtaining the product. The burn cream can promote rapid healing of burn and scald wound surfaces, the recovery effect of the burn and scald wound surface skins is improved, and no scar remains.
Description
Technical field
The present invention relates to a kind of burn cream and preparation method thereof, be specifically related to a kind of anti-scar salamander collagen burn cream and preparation method thereof.
Background technology
According to statistics, China is every year because of in the death toll of unexpected injury, and burn is only second to vehicle accident, comes second, and also has a large amount of wounded to be burnt in vehicle accident injury.Burn processes improperly and often causes patient's scar, and burn scar not only damages appearance, also can affect the physiological function of linked groups or organ, and if burn scar is in the impact feed of mouth place, affect one's power of vision outside eye or eyelid, near nostril, impact is breathed.So dispel our healthy living of burn scar guarantee as early as possible.Now some hospital has the method for relevant elimination cicatrix, but is all realized by the scar operation of dispelling of some clinical repair, more complicated, and costly, so the best way still scalds rear timely medication, from carrying out strick precaution at first, prevents from staying scar.
Existing ointment for treating burn composition is all mainly some animal oil, Chinese medicines etc., can only play the effects such as disinfecting detoxifying, activating blood circulation to dissipate blood stasis, removing the necrotic tissue and promoting granulation, hemostasis and pain-relieving, but can not help to repair skin, prevent from staying scar.Based on this, the invention provides a kind of anti-scar salamander collagen burn cream and preparation method thereof.
Summary of the invention
The object of this invention is to provide a kind of anti-scar salamander collagen burn cream and preparation method thereof, to promote the quickly-healing of empyrosis wound surface, improve the recovery effects of empyrosis wound surface skin, prevent from staying cicatrix.
For achieving the above object, technical scheme of the present invention is: a kind of anti-scar salamander collagen burn cream, it is by the salamander collagen 5 ~ 15g of following proportioning raw materials, Andrias davidianus Blanchard salamander oil 5 ~ 15ml, Oleum sesami 35 ~ 45ml, Cera Flava 10 ~ 20g, SANHUANG 30 ~ 40g and Borneolum Syntheticum 3 ~ 5g, and additional being modulated into by above-mentioned raw materials has the vaseline composition of certain stickiness ointment; Described SANHUANG by weight ratio be the Rhizoma Coptidis of 1:1:1, Cortex Phellodendri and Radix Et Rhizoma Rhei form.Wherein, by above-mentioned raw materials proportioning, required vaseline is 10 ~ 15g.
The preparation method of described a kind of anti-scar salamander collagen burn cream, comprises the steps:
(1), by above-mentioned raw materials proportioning get each raw material, SANHUANG and Borneolum Syntheticum are all ground into Powdered, for subsequent use;
(2), by Cera Flava melt, then add Oleum sesami and SANHUANGFEN, after mixing boils 15 ~ 20min at 100-105 DEG C, filter, get liquid;
(3), be down to after room temperature until temperature of liquid, add Andrias davidianus Blanchard salamander oil and Borneolum Syntheticum powder, under being then placed in 4-10 DEG C of temperature;
(4), when temperature of liquid drops to 4-10 DEG C add salamander collagen, stirring and evenly mixing, finally add the ointment that vaseline is modulated into certain stickiness, obtain product.
The ultraviolet of normal skin to occurring in nature has that protection stops, protection deep skin cell from the effect of uv damage, and outside the deep skin cell of burnt degree is exposed to, easily infects under ultraviolet irradiation.Andrias davidianus Blanchard salamander collagen in burn cream of the present invention can absorb ultraviolet light, makes empyrosis wound surface place be exposed to the injury of outer deep skin cell from ultraviolet light, reduces traumatic infection, promote wound healing.In addition, known by analysis, salamander collagen comprises multiple human body essential amino acid, and this is more conducive to the healing promoting burn and scald wound.
Andrias davidianus Blanchard salamander oil component can suppress the nitric oxide production generation of wound tissue, thus reduces the release of wound inflammation cytokine, and plays bacteriostatic activity, participates in and wound healing.
Vaseline can form one protecting film in skin surface, the moisture of skin is not easily evaporated lost, blocks from the antibacterial in air and contact skin, thus reduces the probability of infection.And it is extremely water insoluble, can be attached on skin for a long time, therefore there is good moistening effect, make the skin histology of wound location keep optimum state, accelerate the repair ability of skin self.
Beneficial effect:
Burn cream of the present invention, compared with burn medicine existing on market, has the special efficacy of wound healing fast (about 7 days), preventing from scar.
Burn cream of the present invention has refrigerant paralysis effect to wound, can reduce the pain of patient.
Burn cream of the present invention can Shi Tang burn wound recover skin keep smooth, strengthen skin elasticity, prevent xerosis cutis, have skin care effect concurrently.
Burn cream of the present invention is with salamander collagen for primary raw material, and form with Giant salamander oil, Oleum sesami, Borneolum Syntheticum, vaseline, SANHUANG and Cera Flava Chinese medicine material mixing preparation, all raw materials are all pure naturals, have no side effect to skin.
Burn cream of the present invention is applicable to skin scald, fire victim, especially to once to superficial second degree burn, scald better effects if.
Detailed description of the invention
The formula of four embodiments below the present invention is all prepared according to previously described preparation method.
Embodiment 1
A kind of anti-scar salamander collagen burn cream, it is by the salamander collagen 5g of following proportioning raw materials, Andrias davidianus Blanchard salamander oil 10ml, Oleum sesami 35ml, Cera Flava 20g, SANHUANG 30g and Borneolum Syntheticum 5g, and additional being modulated into by above-mentioned raw materials has the vaseline composition of certain stickiness ointment; Described SANHUANG by weight ratio be the Rhizoma Coptidis of 1:1:1, Cortex Phellodendri and Radix Et Rhizoma Rhei form, additional vaseline is 10g.
Embodiment 2
A kind of anti-scar salamander collagen burn cream, it is by the salamander collagen 10g of following proportioning raw materials, Andrias davidianus Blanchard salamander oil 10ml, Oleum sesami 40ml, Cera Flava 15g, SANHUANG 35g and Borneolum Syntheticum 3.9g, and additional being modulated into by above-mentioned raw materials has the vaseline composition of certain stickiness ointment; Described SANHUANG by weight ratio be the Rhizoma Coptidis of 1:1:1, Cortex Phellodendri and Radix Et Rhizoma Rhei form, additional vaseline is 12g.
Embodiment 3
A kind of anti-scar salamander collagen burn cream, it is by the salamander collagen 15g of following proportioning raw materials, Andrias davidianus Blanchard salamander oil 5ml, Oleum sesami 45ml, Cera Flava 10g, SANHUANG 35g and Borneolum Syntheticum 3g, and additional being modulated into by above-mentioned raw materials has the vaseline composition of certain stickiness ointment; Described SANHUANG by weight ratio be the Rhizoma Coptidis of 1:1:1, Cortex Phellodendri and Radix Et Rhizoma Rhei form, additional vaseline is 15g.
Embodiment 4
A kind of anti-scar salamander collagen burn cream, it is by the salamander collagen 10g of following proportioning raw materials, Andrias davidianus Blanchard salamander oil 5ml, Oleum sesami 35ml, Cera Flava 10g, SANHUANG 40g and Borneolum Syntheticum 4g, and additional being modulated into by above-mentioned raw materials has the vaseline composition of certain stickiness ointment; Described SANHUANG by weight ratio be the Rhizoma Coptidis of 1:1:1, Cortex Phellodendri and Radix Et Rhizoma Rhei form, additional vaseline is 12g.
The property of medicine is tested
Take rat as laboratory animal, form superficial second degree burn on rat skin surface, wound surface area is 0.7cm
2.
Medication: rats after burn position clear water is rinsed 1--2min, then disinfects in alcohol, gets appropriate ointment uniform application afterwards at the position of rats after burn, covers whole injury and gets final product (thickness is thinner than 1mm), note wound health.Change new drug every 12h, before changing dressings at every turn, the medicine remained on wound surface and liquefied substance must be wiped away, and disinfect in alcohol, SM is until recover.
Experimental group: adopt ointment of the present invention, carries out drug treatment by above-mentioned medication to rats after burn position, and the time was limited with 7 days, every other day carries out surveying record to the wound surface size at rats after burn position.
Matched group: adopt burn cream common on the market, carry out drug treatment by above-mentioned medication to rats after burn position, the time was limited with 7 days, every other day carried out surveying record to the wound surface size at rats after burn position.
Experimental result:
Result shows: experimental group adopts anti-scar salamander collagen burn cream of the present invention to carry out drug treatment to rats after burn wound surface, and administration the 7th day wound surface can be fully recovered, and does not have scar.
Matched group adopts existing general burn cream on the market to treat, and the area of administration the 7th day rat burn wound is 0.2cm
2, not recovery from illness; Matched group adopts general burn cream continuation administration to fully recover after 3 days, leaves the cicatrix protuberance that a 0.5mm is long after recovery from illness.
Claims (2)
1. an anti-scar salamander collagen burn cream, it is characterized in that: it is by the salamander collagen 5 ~ 15g of following proportioning raw materials, Andrias davidianus Blanchard salamander oil 5 ~ 15ml, Oleum sesami 35 ~ 45ml, Cera Flava 10 ~ 20g, SANHUANG 30 ~ 40g and Borneolum Syntheticum 3 ~ 5g, and additional being modulated into by above-mentioned raw materials has the vaseline composition of certain stickiness ointment; Described SANHUANG by weight ratio be the Rhizoma Coptidis of 1:1:1, Cortex Phellodendri and Radix Et Rhizoma Rhei form.
2. the preparation method of a kind of anti-scar salamander collagen burn cream as claimed in claim 1, is characterized in that: comprise the steps:
(1), by above-mentioned raw materials proportioning get each raw material, SANHUANG and Borneolum Syntheticum are all ground into Powdered, for subsequent use;
(2), by Cera Flava melt, then add Oleum sesami and SANHUANGFEN, after mixing boils 15 ~ 20min at 100-105 DEG C, filter, get liquid;
(3), be down to after room temperature until temperature of liquid, add Andrias davidianus Blanchard salamander oil and Borneolum Syntheticum powder, under being then placed in 4-10 DEG C of temperature;
(4), when temperature of liquid drops to 4-10 DEG C add salamander collagen, stirring and evenly mixing, finally add the ointment that vaseline is modulated into certain stickiness, obtain product.
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| CN201510798413.3A CN105233271B (en) | 2015-11-19 | 2015-11-19 | A kind of anti-scar salamander collagen burn cream and preparation method thereof |
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| CN201510798413.3A CN105233271B (en) | 2015-11-19 | 2015-11-19 | A kind of anti-scar salamander collagen burn cream and preparation method thereof |
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| CN105233271B CN105233271B (en) | 2018-08-31 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999213A (en) * | 2016-06-15 | 2016-10-12 | 通江县光泰科技发展有限责任公司 | Preparation method of giant salamander skin ointment for repairing human skin |
| CN109646513A (en) * | 2019-02-28 | 2019-04-19 | 都江堰同兴金色池塘大鲵养殖有限责任公司 | A kind of Chinese medicine composition and preparation method thereof for treating burn and scald |
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| CN101254246A (en) * | 2008-04-03 | 2008-09-03 | 华中科技大学 | External-used burn and scald treating medicine and its preparation |
| CN101648014A (en) * | 2008-08-13 | 2010-02-17 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating skin injury and ulcer and application thereof |
| CN102335288A (en) * | 2010-07-20 | 2012-02-01 | 陕西理工学院 | Giant salamander skin mucus scalding ointment |
| CN105018555A (en) * | 2015-08-06 | 2015-11-04 | 重庆馗丰食品有限公司 | Preparation method of giant salamander skin collagen peptide |
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2015
- 2015-11-19 CN CN201510798413.3A patent/CN105233271B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101254246A (en) * | 2008-04-03 | 2008-09-03 | 华中科技大学 | External-used burn and scald treating medicine and its preparation |
| CN101648014A (en) * | 2008-08-13 | 2010-02-17 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating skin injury and ulcer and application thereof |
| CN102335288A (en) * | 2010-07-20 | 2012-02-01 | 陕西理工学院 | Giant salamander skin mucus scalding ointment |
| CN105018555A (en) * | 2015-08-06 | 2015-11-04 | 重庆馗丰食品有限公司 | Preparation method of giant salamander skin collagen peptide |
Non-Patent Citations (1)
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| 万军梅: "大鲵不同部位制备物治疗烫伤及冻伤作用研究", 《医药导报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999213A (en) * | 2016-06-15 | 2016-10-12 | 通江县光泰科技发展有限责任公司 | Preparation method of giant salamander skin ointment for repairing human skin |
| CN109646513A (en) * | 2019-02-28 | 2019-04-19 | 都江堰同兴金色池塘大鲵养殖有限责任公司 | A kind of Chinese medicine composition and preparation method thereof for treating burn and scald |
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| CN105233271B (en) | 2018-08-31 |
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Effective date of registration: 20230522 Address after: 2nd Floor, Hongchu Technology Building, No. 18 Chuncheng Road, High tech Zone, Luoyang Area, China (Henan) Free Trade Pilot Zone, Luoyang City, Henan Province, 471000 Patentee after: LUOYANG BAKU BIO-TECH Co.,Ltd. Address before: No.71, Luolong Road, Luolong District, Luoyang City, Henan Province Patentee before: LUOYANG NORMAL University |
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