CN104306358B - Antipruritic scar liniment of dispelling - Google Patents
Antipruritic scar liniment of dispelling Download PDFInfo
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- CN104306358B CN104306358B CN201410618822.6A CN201410618822A CN104306358B CN 104306358 B CN104306358 B CN 104306358B CN 201410618822 A CN201410618822 A CN 201410618822A CN 104306358 B CN104306358 B CN 104306358B
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Abstract
The invention provides a kind of antipruritic scar liniment of dispelling, comprise filmogen, aromatic and penetration enhancer, plasticizer, pH adjusting agent, antiseptic.Described liniment can play Quick itch stopping detumescence effect for mosquito bite, can be used for again the elimination of skin scar.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, be specifically related to a kind of antipruritic scar liniment of dispelling.
Background technology
Mosquito belongs to Insecta Diptera, is small-sized insecticide, and kind is a lot, and the known world has kind more than 3000, China has found that more than 300 plant, but energy disseminator animal diseases is not too many, mainly anopheles, culex, yellow-fever mosquito.Mosquito has elongated chanting and foot, there is special vein and typically sting sucking mouth part, it is not only sucked blood and stabs the rest that skin hinders people, and can propagate the infectious disease such as filaricide, malaria, encephalitis, dengue fever, and therefore mosquito is one of harm humans the most serious healthy insecticide.Mosquito bite is autumn in summer warm moist commonly encountered diseases in season, bite rear many Dermal exposure position or directly contact site occur circular or oval, the grain of rice is large or the red papules of Semen Glycines size, mound scar rash or edematous erythema, erythra central authorities common pinhead-sized " bite mark ", and itch with violent tumor, especially being night very.
As everyone knows, the temperature rises, and mosquito will harass the mankind, not only affects the sleep of people, but also the skin of bites humans, not only make people's sufferings, also may infect Other diseases.Mosquito bite can play bag, this mainly the saliva of skin to insect have anaphylaxis, some is all moved back to go down by a wheat harvesting period red packet serious after mosquito bite.For mosquito bite, present various folk prescription and medicine very many, folk prescription such as Aloe, zicao soft plaster etc. are not necessarily all effective to everyone.The medicine of common menthocamphorate, essential balm one class has alcoholic content, and the people being not suitable for skin sensitivity uses.As for the medicine of hormones, antipruritic effect can clearly, but child needs to be cautious use of.
At present, generally by after mosquito bite, redness is alleviated with mosquito acidic toxins in available soap or the rear local of sodium bicarbonate dilution, clean with such as green ointment, floral water, WUJI GAO, Calamine Lotion etc. the place of biting antipruritic simultaneously, but above effect is not ideal, be difficult to the effect reaching rapid repellent antipruritic.
In addition, we daily life and work in, often because the reasons such as wound, burn, operation, treatment skin ulcer leave over lower various cicatrix on human body surface, cause the pole of health skin unsightly.Human body cicatrix is roughly summarized as several as follows: epidermis no concave-convex is the pigmented cicatrix of the dark brown change of color of the leather purplish-black; Concavo-convex and the mottle trace of the dark brown change of purplish-black of epidermis; High convex hard and " pimple " cicatrix of reddish violet change of epidermis; The convex hard reddish violet change of the spontaneous height of epidermis, and constantly expand, the settled tower skin tumour etc. of unlimited development.Although the disease that cicatrix can not be serious, affects appearance attractive in appearance, bring misery to patient, cause sorry.At present, although there is various medicine, all there is weak curative effect, problem that side effect is large.The medicine of the treatment cicatrix that market is sold often there will be anaphylaxis, and therapeutic effect is not obvious, and curative effect is slow.
Summary of the invention
In view of this, the object of the invention is to provide a kind of antipruritic scar liniment of dispelling, and can play Quick itch stopping detumescence effect, can be used for again the elimination of skin scar for mosquito bite.
The concrete technical scheme of the present invention is:
Antipruritic scar liniment of dispelling, it comprises filmogen, aromatic and penetration enhancer, plasticizer, pH adjusting agent, antiseptic.
Preferably, described filmogen is selected from one or more in hydroxypropyl methylcellulose, methylcellulose, hydroxypropyl cellulose, gelatin, arabic gum, sodium carboxymethyl cellulose, polyvinyl alcohol, PVP K30, sodium alginate and zein.
Preferably, described aromatic and penetration enhancer are made up of following material: Mentholum, Borneolum Syntheticum, eucalyptus oil, Oleum Camphora, Oleum Caryophylli and Oleum Cinnamomi.
Preferably, described plasticizer is selected from one or more in glycerol, propylene glycol and PEG400.
Preferably, described pH adjusting agent is selected from the one in sodium carbonate, sodium bicarbonate and triethylamine.
Preferably, described antiseptic is methyl hydroxybenzoate and/or propylparaben.
Preferably, described aromatic and penetration enhancer are mixed with alcoholic solution.
Preferably, described aromatic and penetration enhancer are mixed with the alcoholic solution of 15%.
Preferably, described liniment, specifically comprises following component:
Filmogen 10-15g
Aromatic and penetration enhancer alcoholic solution 10ml
Plasticizer 2-5g
PH adjusting agent adjusts pH to 7.5 ~ 8
Antiseptic 0.1g
The preferred embodiments of the invention further demonstrate that, the content of filmogen, plasticizer, aromatic and promoter affects larger on technique effect, as employing filmogen 10-15g, aromatic and penetration enhancer alcoholic solution 10ml, plasticizer 2-5g, pH adjusting agent adjusts pH to 7.5 ~ 8, and during antiseptic 0.1g, effective percentage is higher than effective percentage during other proportionings.
More preferably, described liniment, comprises following component:
Hydroxypropyl methylcellulose 5g
Sodium alginate 8.5g
Mentholum 0.5g
Eucalyptus oil 0.5g
Oleum Caryophylli 0.5g
Glycerol 3.5g
Sodium bicarbonate 0.60g
Dehydrated alcohol 10mL
Methyl hydroxybenzoate 0.05g
Propylparaben 0.05g
The preparation method of described liniment, comprises the steps: that getting filmogen is placed in distilled water, is heated to 80 degree, is stirred to dissolving, after being cooled to room temperature, adds plasticizer; Stir, add pH adjusting agent, adjustment pH value of solution to 7.5 ~ 8; Add antiseptic to stir, add the alcoholic solution of aromatic and penetration enhancer, stir; Add distilled water standardize solution and get final product.
Preferably, described preparation method comprises the steps: that getting a kind or several filmogen 10 ~ 15g material is placed in about 80mL distilled water, is heated to 80 degree, is stirred to dissolving, after being cooled to room temperature, add 2-5g plasticizer; Stir, add pH adjusting agent, adjustment pH value of solution to 7.5 ~ 8; Add 0.1g antiseptic to stir, add the aromatic of 10mL15% and the alcoholic solution of penetration enhancer, stir; Add distilled water to 100mL and get final product.
Liniment of the present invention forms protecting film at mosquito bite position, decreases the scratching of patient for affected part; The existence of protecting film makes illing skin moistening, under the effect of penetration enhancer, aromatic and pH adjusting agent penetrate into affected part play in and affected part formic acid and then reduce scratchy, pain perception; For affected part transudate protecting film, there is certain absorbability, add to its protective capability, decrease the infection chance in affected part, and swollen itching can be eliminated fast.
On the other hand, liniment of the present invention can improve and prevent because of operation and the hypertrophic cicatrix that causes of other wounds and scar tumor scars.Smearing rear a few minutes can form membranoid substance and cover scar surface, make the humidity and temperature that cicatrix keeps certain, while softening cicatrix, acute activation damaged cell, upgrades skin histology, rebuild skin acid adipose membrane, promote cell regeneration, calm down cicatrix, disintegrate pigment, even skin tone, suppresses the growth of cicatrix.Leave over cicatrix after being applicable to traumatic injury, scratch, skin burn, scald, puerperal striae gravidarum, post-surgical scars, acne scars, the cicatrix etc. that skin pigmentation after mosquito stings, cigarette scar, level and smooth face's fine wrinkles and comedo stay.
Detailed description of the invention
The following examples only in order to more detailed description the present invention, but do not limit the present invention in any form.
embodiment 1
Prescription:
Hydroxypropyl methylcellulose 5g
Sodium alginate 8.5g
Mentholum 0.5g
Eucalyptus oil 0.5g
Oleum Caryophylli 0.5g
Glycerol 4.0g
Sodium bicarbonate 0.60g
Dehydrated alcohol 10mL
Methyl hydroxybenzoate 0.05g
Propylparaben 0.05g
Distilled water adds to 100mL
Preparation method:
Add in 75mL distilled water under getting the hydroxypropyl methylcellulose of recipe quantity and sodium alginate 250rpm stirring condition, be heated to 80 DEG C, be stirred to dissolving; After being cooled to room temperature, adding glycerol, sodium bicarbonate successively, stir; Add methyl hydroxybenzoate and propylparaben, stirring and dissolving; Add the alcoholic solution of Mentholum, eucalyptus oil, Oleum Caryophylli, be stirred well to even, viscous liquid, supplement distilled water and stir to 100mL and get final product.
embodiment 2
Prescription:
Methylcellulose 10.0g
Polyvinyl alcohol 3.5g
Oleum Caryophylli 0.7g
Borneolum Syntheticum 0.8g
Propylene glycol 4.5g
Sodium carbonate 0.35g
Dehydrated alcohol 10mL
Methyl hydroxybenzoate 0.05g
Propylparaben 0.05g
Distilled water adds to 100mL
Preparation method:
Add in 75mL distilled water under getting the methylcellulose of recipe quantity and polyvinyl alcohol 250rpm stirring condition, be stirred to dissolving at 85 DEG C, be cooled to room temperature; Add propylene glycol, sodium carbonate successively, stir; Add methyl hydroxybenzoate and propylparaben, stirring and dissolving; Add the alcoholic solution of Oleum Caryophylli, Borneolum Syntheticum, be stirred well to even, viscous liquid, supplement distilled water and stir to 100mL and get final product.
embodiment 3
Prescription:
PVP K30 6.5g
Sodium carboxymethyl cellulose 8.0g
Mentholum 0.5g
Borneolum Syntheticum 1.0g
Propylene glycol 2.0g
Glycerol 1.5g
Triethylamine 0.10g
Dehydrated alcohol 10mL
Methyl hydroxybenzoate 0.05g
Propylparaben 0.05g
Distilled water adds to 100mL
Preparation method:
Add in 75mL distilled water under getting the PVP K30 of recipe quantity and sodium carboxymethyl cellulose 250rpm stirring condition, stirred at ambient temperature is to dissolving; Add glycerol, triethylamine successively, stir; Add methyl hydroxybenzoate and propylparaben, stirring and dissolving; Add the alcoholic solution of Mentholum, Borneolum Syntheticum, be stirred well to even, viscous liquid, supplement distilled water and stir to 100mL and get final product.
embodiment 4
Prescription:
Arabic gum 5.0g
Hydroxypropyl cellulose 3.5g
Sodium carboxymethyl cellulose 3.0g
Mentholum 1.0g
Oleum Cinnamomi 0.4g
Propylene glycol 2g
Glycerol 2g
Sodium carbonate 0.28g
Dehydrated alcohol 10mL
Methyl hydroxybenzoate 0.05g
Propylparaben 0.05g
Distilled water adds to 100mL
Preparation method:
Add in 75mL distilled water under getting the arabic gum of recipe quantity, hydroxypropyl cellulose and sodium carboxymethyl cellulose 250rpm stirring condition, stirred at ambient temperature is to dissolving; Add glycerol, propylene glycol and sodium carbonate successively, stir; Add methyl hydroxybenzoate and propylparaben, stirring and dissolving; Add the alcoholic solution of Mentholum, Oleum Cinnamomi, be stirred well to even, viscous liquid, supplement distilled water and stir to 100mL and get final product.
clinical trial one,
Treatment mosquito bite observation of curative effect
1, test material
(1) medicine: liniment of the present invention.(2) control drug: fluocinonide Borneolum Syntheticum ointment.
2, diagnostic criteria (1) all cases all have mosquito or other sting;
(2) the violent pruritus in rear local is bitten;
3, criterion of therapeutical effect is worked out according to (Chinese medical disease Standardization of diagnosis and curative effect);
Cure: whole body and local symptom disappear, red swelling of the skin, heat, bitterly, itch and disappear.
Take a turn for the better: whole body and local symptom alleviate, and swelling is disappeared.
Invalid: whole body and local symptom do not control, and even increase the weight of.
4, choose mosquito bite patient 100 example, be divided into treatment group and matched group at random.Treatment group 50 example, man 26 example, female 24 example; Age 2-40 year.Matched group 50 example, man 24 example, female 26 example; Age 4-38 year.Two groups of no significant difference (P>0.05) in age, sex, the course of disease etc., have comparability.
5, therapeutic outcome: after mosquito bite skin, uniform application is in red swelling of the skin place, and dose adjusts according to Tumor size, 2 times/d.Therapeutic outcome sees the following form.
Table 1. liang group clinical drug comparitive study,
Result: by controlled clinical trial, adds up two groups of clinical efficacies, according to healing, take a turn for the better, invalid, always have 100 patients and finally reach evaluation criteria, its total effective rate 98% for the treatment of group, cure rate 76%, the lump produced at treatment mosquito bite causes Be very effective in sufferings symptom.
clinical trial two,scar of dispelling effect expedition
eXPERIMENTAL DESIGN
This research is that two centers are random, double blinding, placebo clinical research.This research design effective sample number is 60 examples, and test group and matched group are respectively 30 examples.Consider 20% expulsion rate, planning into group case load is 72 examples, test group and each 36 examples of placebo group.
statistical method
Statistical analysis adopts SAS9.0 statistical analysis software to calculate.All statistical test all adopt two-sided test, and P value < 0.05 will be considered to checked difference statistical significance.Test group and matched group first carry out statistical analysis with regard to physical data, describe patient's ordinary circumstance, after confirming comparability, carry out clinical efficacy carry out statistical analysis to two groups of cases.Different with problem according to data character, main work is analyzed as follows:
(1) harmonious inspection, whether age of check test group and case in matched group, sex and cicatrix time of origin length equal distribution be balanced, the employing t method of inspection or pearsonx
2the method of inspection.
(2) efficacy analysis, clinical indices according to the rules judges curative effect, to effective percentage and the course for the treatment of degree analyze, analytical method adopts pearsonx
2the method of inspection or the difference between wilcoxon method check test group and matched group have not statistically significant.
(3) if two groups have the factor affected the treatment unbalanced, adopt Multivariate to carry out adjustment to curative effect index and analyze, to confirm curative effect situation.Method adopts orderly logistic analytical method.
Table 2. clinical trial statistical analysis:
Note: adopt the t method of inspection.Selected object 72 example, come off 11 examples.
In addition, test group and matched group experimenter sex, age, height, the more equal not statistically significant of body weights.
main research:
Effective: color and luster (red, flushing or purple) shoals, cicatrix hardness (hard, moderate, soft) deliquescing, demarcate clear (clear, fuzzy) with normal skin, subjective symptoms is obviously alleviated.
Effective: color and luster (red, flushing or purple) shoals, cicatrix hardness (hard, moderate, soft) deliquescing, or demarcate clear (clear, fuzzy) with normal skin, or subjective symptoms is obviously alleviated.
Invalid: without changing.
Increase the weight of: color and luster (red, flushing or purple) is deepened, cicatrix hardness (hard, moderate, soft) is hardening, and demarcate unintelligible (clear, fuzzy) with normal skin, subjective symptoms increases the weight of.
Effective percentage after table 3. uses two weeks compares
Note: be percentage rate in bracket.Adopt pearsonx
2check to obtain P < 0.001.
After table 4. uses two weeks, therapeutic effect compares
Note: be percentage rate in bracket.Wilcoxon method is adopted to obtain P < 0.001.
Clinical testing data further demonstrate that superiority of the present invention.
Claims (4)
1. an antipruritic scar liniment of dispelling, it is characterized in that, it comprises following component:
Wherein, described filmogen is selected from one or more in hydroxypropyl methylcellulose, methylcellulose, hydroxypropyl cellulose, gelatin, arabic gum, sodium carboxymethyl cellulose, polyvinyl alcohol, PVP K30, sodium alginate and zein;
Described aromatic and penetration enhancer be selected from Mentholum, Borneolum Syntheticum, eucalyptus oil, Oleum Camphora, Oleum Caryophylli and Oleum Cinnamomi one or more;
Described plasticizer be selected from glycerol, propylene glycol and PEG400 one or more;
Described pH adjusting agent is selected from the one in sodium carbonate, sodium bicarbonate and triethylamine;
Described antiseptic is methyl hydroxybenzoate and/or propylparaben.
2. liniment according to claim 1, is characterized in that, it comprises following component:
3. liniment according to claim 1 treats the application in the medicine of skin sufferings or the redness caused by mosquito bite in preparation.
4. liniment according to claim 1 eliminates the application in the medicine of skin scar in preparation.
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| CN201410618822.6A CN104306358B (en) | 2014-11-06 | 2014-11-06 | Antipruritic scar liniment of dispelling |
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| CN201410618822.6A CN104306358B (en) | 2014-11-06 | 2014-11-06 | Antipruritic scar liniment of dispelling |
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| CN104306358B true CN104306358B (en) | 2015-11-18 |
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| CN104983721A (en) * | 2015-06-25 | 2015-10-21 | 河南行知专利服务有限公司 | Scar repairing paste |
| CN105292672A (en) * | 2015-10-23 | 2016-02-03 | 周宇恒 | Dual-purpose bottle and loading method thereof |
| CN105168632A (en) * | 2015-10-25 | 2015-12-23 | 戴礼礼 | Traditional Chinese medicinal plastics for promoting healing of wound of cesarean section and preparation method thereof |
| CN105878427A (en) * | 2016-05-13 | 2016-08-24 | 陈伟 | Peony seed oil compound spray for curing burn and scald and preparation method |
| CN106389290A (en) * | 2016-11-14 | 2017-02-15 | 天津贝罗尼生物科技有限公司 | Scar removal cream containing PDGF (Platelet Derived Growth Factor) and preparation method of scar removal cream |
| CN107412392A (en) * | 2017-05-25 | 2017-12-01 | 江西山友龙脑科技有限公司 | A kind of externally applied liniment for treating mosquito bite and insect bite and preparation method thereof |
| CN106963838A (en) * | 2017-05-25 | 2017-07-21 | 江西山友龙脑科技有限公司 | A kind of externally applied liniment for treating boiling hot burn and preparation method thereof |
| CN108785379A (en) * | 2018-06-26 | 2018-11-13 | 苏州尚宜佳生物科技有限公司 | One kind gram vertical refrigerant release membranes of boron sieve and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934012A (en) * | 2010-08-16 | 2011-01-05 | 山西康意制药有限公司 | Gel ointment for treating rheumatic arthritis and traumatic injury |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934012A (en) * | 2010-08-16 | 2011-01-05 | 山西康意制药有限公司 | Gel ointment for treating rheumatic arthritis and traumatic injury |
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