CN101703667B - Brown red medicament for treating traumatic injuries and preparation method thereof - Google Patents
Brown red medicament for treating traumatic injuries and preparation method thereof Download PDFInfo
- Publication number
- CN101703667B CN101703667B CN200910225965XA CN200910225965A CN101703667B CN 101703667 B CN101703667 B CN 101703667B CN 200910225965X A CN200910225965X A CN 200910225965XA CN 200910225965 A CN200910225965 A CN 200910225965A CN 101703667 B CN101703667 B CN 101703667B
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- weight parts
- weight
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a brown red medicament for treating traumatic injuries and a preparation method thereof and belongs to the technical field of Chinese medicaments. The medicament is cataplasm prepared from concentrates of ethanol extracts of 39 to 49 weight parts of safflowers, 39 to 49 weight parts of cutch, 39 to 49 weight parts of tangkuei tail, 17 to 27 weight parts of alum, 39 to 49 weight parts of sappan wood, 39 to 49 weight parts of asparagus, 39 to 49 weight parts of frankincense, 39 to 49 weight parts of benzoin, 39 to 49 weight parts of commiphora molmol and 39 to 49 weight parts of dragon's blood and pharmaceutically acceptable matrix materials. The preparation method comprises: (1) the preparation of the concentrates of the ethanol extracts; (2) the preparation of the matrix materials; and (3) the preparation of the cataplasm. The medicament of the invention has the advantages of small skin simulation, quick absorption and more convenient use and can be used for treating fall wounds, muscles and bones injuries, accumulated stasis, pain with swelling and other symptoms.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, more particularly, it relate to a kind of be used to treat get injured by a fall, the Jiehong medicine for injuries from falls of diseases such as bones and muscles injury, long-pending swelling due to stasis, the invention still further relates to above-mentioned preparation of medicaments method.
Background technology
Soft tissue injury is commonly encountered diseases, a frequently-occurring disease clinically, and worldwide, its sickness rate is only second to flu.Particularly be engaged in amusement, sports, or blue-collar philtrum, seldom do not suffering soft tissue injury.Soft tissue injury is meant that various causative factors of injury act on body and cause the disease of a series of pathological changes of soft tissue, and its pathological change is a principal character with local acute inflammation and reparation.Clinical local swelling, pain, dysfunction, the livid purple ecchymosis etc. of mainly showing as.Be divided into two kinds of acute injury (acute trauma) and chronic injuries (chronic trauma), and chronic injury is come by the acute injury transformation often, so acute soft tissue injury need obtain in time, efficacious therapy.Modern medicine has the main Therapeutic Method of acute soft tissue injury: wrapping, partial closure, physical therapy etc., and these method curative effects are not good enough, and rehabilitation duration is longer.The medicine for external use of treatment acute soft tissue injury with apply ointment or plaster, ointment, plaster, medicine loose is main; These medicines are main with conventional dosage forms mainly again, exist dosage form to fall behind and use inconvenience, positions such as trunk to be difficult for deficiencies such as wrapping is firm, the medicated clothing that is prone to make dirty, waste medicine; Hindered further and promoted the use; Also seek and treat acute soft tissue injury with medicinal herb spray, but its complicated process of preparation, reasons such as cost costliness have hindered further popularization.
Chinese medicine " exhausts red traumatic injury ", and the side mainly is made up of Sanguis Draxonis, Flos Carthami, Olibanum, Myrrha, Aloe, Radix Angelicae Sinensis, catechu, Lignum Sappan etc.; Generally use, be used to get injured by a fall bones and muscles injury with tincture; Diseases such as long-pending swelling due to stasis, treatment has remarkable advantages and unique curative effect to soft tissue injury.But also there are two big subject matters at present in it: the one, and preparation process is backward relatively, and using dosage once is bigger, and local irritation is arranged, and has reduced patient's compliance, and quality standard is perfect inadequately, has limited its further developing in market; The 2nd, exhaust red traumatic injury tincture when patient uses, put the affected part on the skin after must soaking medicinal liquid with Cotton Gossypii, and attach affected part and make lasting soak after soaking into medicinal liquid with gauze; Again because the solvent volatility of tincture is strong; Be prone to drying, in order to keep moistening, patient must add medicinal liquid at any time; Equally also reduce patient's compliance, restricted its clinical practice.Having become this sick problem demanding prompt solution of treatment so study the modern preparation of external evident in efficacy, lasting, easy to use, also is an important topic of modernization of cmm.
Summary of the invention
The technical problem that the present invention will solve is the above-mentioned deficiency to prior art, diseases such as a kind of more effectively treatment is got injured by a fall, bones and muscles injury, long-pending swelling due to stasis is provided, the Jiehong medicine for injuries from falls little to skin irritation, that drug absorption fast, use is convenient.
Another technical problem that the present invention will solve provides a kind of method for preparing of above-mentioned novel Jiehong medicine for injuries from falls.
Last technical scheme of the present invention is such: a kind of Jiehong medicine for injuries from falls; Be the cataplasma of being processed by the ethanol extraction concentrated solution and the receptible host material of pharmaceutics of 39～49 parts on Flos Carthami, 39～49 parts in catechu, 39～49 parts of Radix Angelicae Sinensis, 17～27 parts of Alumens, 39～49 parts of Lignum Sappans, 39～49 parts of Aloes, 39～49 parts of Olibanums, 39～49 parts of Benzoinumes, 39～49 parts of Myrrhas, 39～49 parts of Sanguis Draxonis, above-mentioned deal is a weight portion.
Further; A kind of Jiehong medicine for injuries from falls of the present invention; Its preferred plan is the cataplasma of being processed by the ethanol extraction concentrated solution of 44 parts on Flos Carthami, 44 parts in catechu, 44 parts of Radix Angelicae Sinensis, 22 parts of Alumens, 44 parts of Lignum Sappans, 44 parts of Aloes, 44 parts of Olibanums, 44 parts of Benzoinumes, 44 parts of Myrrhas, 44 parts of Sanguis Draxonis and the receptible host material of pharmaceutics, and above-mentioned deal is a weight portion.
In above-mentioned a kind of Jiehong medicine for injuries from falls, described ethanol extraction concentrated solution is that extracting solution is concentrated into 25～35% of medical material weight; The weight ratio of described ethanol extraction concentrated solution and host material is 1: 2.0～5.0.
In above-mentioned a kind of Jiehong medicine for injuries from falls; Described host material is to be selected from sodium polyacrylate, carbopol, hypromellose, polyvinylpyrrolidone, gelatin, Kaolin, silica gel, dihydroxyaluminum aminoacetate, ethylenediaminetetraacetic acid, 1, the wherein two or more at least mixture of 2-propylene glycol, tartaric acid, tween, distilled water, glycerol, azone.The preferred following material of described host material mixes by weight proportion; 0.01～1 part of 1～5 part of sodium polyacrylate, 1～5 part of carbopol, 1～10 part of Kaolin, 1～10 part in silica gel, 0.01～0.1 part of dihydroxyaluminum aminoacetate, ethylenediaminetetraacetic acid, 1,0.1～1 part of 2-propylene glycol, 0.01～0.1 part in tartaric acid, 10～50 parts of distilled water, 1～10 part of glycerol, 0.1～2 part of azone.
In above-mentioned a kind of Jiehong medicine for injuries from falls; Also be added with the unguentum usual auxiliaries of concentrated solution weight 0.1～1% in the described ethanol extraction concentrated solution; Described unguentum usual auxiliaries is meant at least a in menthol, Mentholum, Borneolum Syntheticum, azone, eucalyptus oil, Oleum Ricini, the methyl salicylate, with the flexibility, the tolerance to cold that improve medicament or play the Percutaneous absorption enhancer effect.
Back of the present invention one technical scheme is such: a kind of method for preparing of Jiehong medicine for injuries from falls comprises the preparation of (1) ethanol extraction concentrated solution, the preparation of the preparation of (2) host material and (3) cataplasma; Wherein the method for preparing of (1) ethanol extraction concentrated solution is to get Flos Carthami, Lignum Sappan, Radix Angelicae Sinensis to be ground into coarse powder; Adopting percolation, make solvent with 60～80% ethanol, is slowly percolation of 1～3ml/min by percolation speed; The ethanol that adds 5 times of amounts of medical material weight is altogether collected percolate; All the other catechu, Alumen, Aloe, Olibanum, Benzoinum, Myrrha, Sanguis Draxonis seven flavors are ground into coarse powder; With 60～80% alcohol dipping of above-mentioned percolate and 3 times of amounts of medical material 30 days; Filter, filtrate decompression is concentrated into 30～40% the concentrated solution that weight is medical material weight; (2) method for preparing of host material is that dihydroxyaluminum aminoacetate, ethylenediaminetetraacetic acid, glycerol and Kaolin is evenly mixed, adds sodium polyacrylate, fully grinds well; Tartaric acid is dissolved in the part distilled water, and gradation joins in the said mixture, stirs; The carbopol adding distil water is dissolved into clear solution, adds again in the said mixture, stir; Add azone, 1 at last, the 2-propylene glycol stirs and promptly gets; (3) method for preparing of cataplasma is promptly to get extracting concentrated solution and the host material mixed by 1: 2.0～5.0, stirred 10～30 minutes, be coated with, cover upper protective film, cut into slices, packing.
In the method for preparing of above-mentioned a kind of Jiehong medicine for injuries from falls; Described ethanol extraction concentrated solution also can prepare as follows: get Flos Carthami, Lignum Sappan, Radix Angelicae Sinensis and be ground into coarse powder; Adopting percolation, make solvent with 60～80% ethanol, is slowly percolation of 1～3ml/min by percolation speed; The ethanol that adds 5 times of amounts of medical material weight is altogether collected percolate; All the other catechu, Alumen, Aloe, Olibanum, Benzoinum, Myrrha, Sanguis Draxonis seven flavors are ground into coarse powder; Add 60～80% ethanol that 3 medical materials doubly measure with twice of ultrasonic Treatment; Two hours for the first time, one hour for the second time, filter; Filtrating and above-mentioned percolate merge and be evaporated to 30～40% the concentrated solution that weight is medical material weight, or add the unguentum usual auxiliaries and stir; Can under the situation that guarantees extraction effect, improve extraction efficiency greatly.
The present invention compared with prior art has following advantage:
(1) cataplasma of the present invention adopts water-soluble base and water solublity, fat-soluble medicine intermiscibility good, and the drug loading of host material is big, is fit to very that Chinese medicine is formed minute more, the medication characteristics of heavy dose.
(2) water content is higher in the cataplasma of the present invention, and the keratodermatitis cell hydration is expanded, and more helps drug transdermal and absorbs.
(3) cataplasma breathability of the present invention is poor, to skin vigorous property, the equal tool of moisture retention obviously be superior to traditional rubber-emplastrum, and use comfortable, little to skin irritation, can take off advantages such as paste not having pain repeatedly.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done to specify further, but do not constitute any restriction of the present invention.
Embodiment 1
One of preparation of ethanol extraction concentrated solution
Component: Flos Carthami 390g, catechu 390g, Radix Angelicae Sinensis 390g, Alumen 170g, Lignum Sappan 390g, Aloe 390g, Olibanum 390g, Benzoinum 390g, Myrrha 390g, Sanguis Draxonis 390g
Method for preparing: getting Flos Carthami, Lignum Sappan, Radix Angelicae Sinensis and be ground into coarse powder, adopt percolation, make solvent with 60% ethanol, is slowly percolation of 1ml/min by percolation speed, adds the ethanol of 5 times of amounts of medical material weight altogether, the collection percolate; All the other catechu, Alumen, Aloe, Olibanum, Benzoinum, Myrrha, Sanguis Draxonis seven flavors are ground into coarse powder, and with 60% alcohol dipping of above-mentioned percolate and 3 times of amounts of medical material 30 days, filtration, it is 30% of medical material weight that filtrate decompression is concentrated into weight, about 1100g.
Embodiment 2
Two of the preparation of ethanol extraction concentrated solution
Component: Flos Carthami 440g, catechu 440g, Radix Angelicae Sinensis 440g, Alumen 220g, Lignum Sappan 440g, Aloe 440g, Olibanum 440g, Benzoinum 440g, Myrrha 440g, Sanguis Draxonis 440g
Method for preparing: getting Flos Carthami, Lignum Sappan, Radix Angelicae Sinensis and be ground into coarse powder, adopt percolation, make solvent with 70% ethanol, is slowly percolation of 2ml/min by percolation speed, adds the ethanol of 5 times of amounts of medical material weight altogether, the collection percolate; All the other catechu, Alumen, Aloe, Olibanum, Benzoinum, Myrrha, Sanguis Draxonis seven flavors are ground into coarse powder; With 70% alcohol dipping of above-mentioned percolate and 3 times of amounts of medical material 30 days; Filter; It is 35% of medical material weight that filtrate decompression is concentrated into weight, and about 1460g adds the 12.5g eucalyptus oil then and mixes.
Embodiment 3
Three of the preparation of ethanol extraction concentrated solution
Component: Flos Carthami 490g, catechu 490g, Radix Angelicae Sinensis 490g, Alumen 270g, Lignum Sappan 490g, Aloe 490g, Olibanum 490g, Benzoinum 490g, Myrrha 490g, Sanguis Draxonis 490g
Method for preparing: getting Flos Carthami, Lignum Sappan, Radix Angelicae Sinensis and be ground into coarse powder, adopt percolation, make solvent with 80% ethanol, is slowly percolation of 3ml/min by percolation speed, adds the ethanol of 5 times of amounts of medical material weight altogether, the collection percolate; All the other catechu, Alumen, Aloe, Olibanum, Benzoinum, Myrrha, Sanguis Draxonis seven flavors are ground into coarse powder; With 80% alcohol dipping of above-mentioned percolate and 3 times of amounts of medical material 30 days; Filter; It is 40% of medical material weight that filtrate decompression is concentrated into weight, and about 1870g adds menthol 2g then and mixes.
Embodiment 4
Four of the preparation of ethanol extraction concentrated solution
Component: Flos Carthami 440g, catechu 440g, Radix Angelicae Sinensis 440g, Alumen 220g, Lignum Sappan 440g, Aloe 440g, Olibanum 440g, Benzoinum 440g, Myrrha 440g, Sanguis Draxonis 440g
Method for preparing: getting Flos Carthami, Lignum Sappan, Radix Angelicae Sinensis and be ground into coarse powder, adopt percolation, make solvent with 70% ethanol, is slowly percolation of 2ml/min by percolation speed, adds the ethanol of 5 times of amounts of weight altogether, the collection percolate; All the other catechu, Alumen, Aloe, Olibanum, Benzoinum, Myrrha, Sanguis Draxonis seven flavors are ground into coarse powder, add 70% ethanol of medical material 3 amounts, with twice of ultrasonic Treatment; Two hours for the first time; One hour for the second time, filter, be 35% of medical material weight with being evaporated to weight after filtrating and the percolate merging; About 1360g adds menthol 2g then and mixes.
Embodiment 5
One of preparation of medicaments
The extract 3.5g that extracting solution concentrated solution: embodiment 1 is prepared.
Host material: sodium polyacrylate (NP-700) 0.9g, Kaolin 4.5g, ethylenediaminetetraacetic acid 0.15g, dihydroxyaluminum aminoacetate 0.03g, 1,2-propylene glycol 0.3g, tartaric acid 0.03g, glycerol 4.5g, azone 0.6g, distilled water 8g.
The host material preparation: dihydroxyaluminum aminoacetate, ethylenediaminetetraacetic acid, glycerol and Kaolin is evenly mixed, add sodium polyacrylate, fully grind well; Tartaric acid is dissolved in the part distilled water, joins at twice in the said mixture, stir; Add azone, 1 at last, the 2-propylene glycol stirs subsequent use.
Preparation of medicaments: the extracting solution concentrated solution is added in the preparation host material, and stirring grinds well, and this mixture stand is applied on the non-woven fabrics, and horizontal positioned covers upper protective film, and section packs room temperature and places, and gets final product.
Usage and consumption: be affixed on the affected part, paste every day one.
Embodiment 6
Two of preparation of medicaments
The extract 4.4g that extracting solution concentrated solution: embodiment 2 is prepared.
Host material: sodium polyacrylate (NP-700) 0.6g, Kaolin 3g, ethylenediaminetetraacetic acid 0.1g, dihydroxyaluminum aminoacetate 0.025g, 1,2-propylene glycol 0.2g, tartaric acid 0.025g, glycerol 3.5g, azone 0.45g, distilled water 6.5g.
The host material preparation: dihydroxyaluminum aminoacetate, ethylenediaminetetraacetic acid, glycerol and Kaolin is evenly mixed, add sodium polyacrylate, fully grind well; Tartaric acid is dissolved in the part distilled water, joins at twice in the said mixture, stir; Add azone, 1 at last, the 2-propylene glycol stirs subsequent use.
Preparation of medicaments: the extracting solution concentrated solution is added in the preparation host material, and stirring grinds well, and this mixture stand is applied on the non-woven fabrics, and horizontal positioned covers upper protective film, and section packs room temperature and places, and gets final product.
Usage and consumption: be affixed on the affected part, paste every day one.
Embodiment 7
Three of preparation of medicaments
The extract 5.7g that extracting solution concentrated solution: embodiment 3 is prepared.
Host material: sodium polyacrylate (NP-700) 0.6g, carbopol (
Ultrez21) 0.3g, Kaolin 4g, ethylenediaminetetraacetic acid 0.12g, dihydroxyaluminum aminoacetate 0.03g, 1,2-propylene glycol 0.25g, tartaric acid 0.02g, glycerol 4g, azone 0.5g, distilled water 6g.
The host material preparation: dihydroxyaluminum aminoacetate, ethylenediaminetetraacetic acid, glycerol and Kaolin is evenly mixed, add sodium polyacrylate, fully grind well; Tartaric acid is dissolved in the part distilled water, joins at twice in the said mixture, stir; The carbopol adding distil water is dissolved into clear solution, adds in the said mixture, stir; Add azone, 1 at last, the 2-propylene glycol stirs subsequent use.
Preparation of medicaments: the extracting solution concentrated solution is added in the preparation host material, and stirring grinds well, and this mixture stand is applied on the non-woven fabrics, and horizontal positioned covers upper protective film, and section packs room temperature and places, and gets final product.
Usage and consumption: be affixed on the affected part, paste every day one.
Embodiment 8
Four of preparation of medicaments
The extract 4.4g that extracting solution concentrated solution: embodiment 4 is prepared.
Host material: sodium polyacrylate (NP-700) 0.6g, carbopol (
980NF) 0.2g, Kaolin 3.5g, ethylenediaminetetraacetic acid 0.15g, dihydroxyaluminum aminoacetate 0.03g, 1,2-propylene glycol 0.5g, tartaric acid 0.02g, glycerol 3.5g, azone 0.4g, distilled water 7g.
The host material preparation: dihydroxyaluminum aminoacetate, ethylenediaminetetraacetic acid, glycerol and Kaolin is evenly mixed, add sodium polyacrylate, fully grind well; Tartaric acid is dissolved in the part distilled water, joins at twice in the said mixture, stir; The carbopol adding distil water is dissolved into clear solution, adds in the said mixture, stir; Add azone, 1 at last, the 2-propylene glycol stirs subsequent use.
Preparation of medicaments: the extracting solution concentrated solution is added in the preparation host material, and stirring grinds well, and this mixture stand is applied on the non-woven fabrics, and horizontal positioned covers upper protective film, and section packs room temperature and places, and gets final product.
Usage and consumption: be affixed on the affected part, paste every day one.
Experimental example 1
The present invention exhausts the skin irritation experimental study of red traumatic injury cataplasma
1. exhaust of the influence of red traumatic injury cataplasma single-dose to rabbit intact skin and damaged skin.
4 of new zealand purebred rabbits, each 2 of intact skin and damaged skins, 24h loses hair or feathers with 8% sodium sulfide before the administration; About 15cm * the 10cm of area divides two districts about spinal column, and the left side is that right side, administration district is the check plot; Veneer amasss and is the cataplasma of 7.5cm * 5cm in depilation administration district, and of the same area cataplasma that contains substrate pasted on the right side, removes cataplasma behind medicine and the contact skin 24h; Observe the dermoreaction situation, record 1h, 24h, 48h, 72h have or not erythema, edema, protuberance, burnt silly formation etc.; And the dermoreaction intensity of every animal marked, observe medicine to the skin irritation situation.Then medicine-feeding part and contrast position are cut respectively, put into 10% formalin and do the pathology histological examination.Damaged skin scratches epidermis with knife blade, the degree of being with the oozing of blood, and other are with the intact skin irritant test.
1.1 skin irritation reaction standards of grading and skin irritation intensity standards of grading
Table 5 skin irritation reaction standards of grading
Table 6 skin irritation intensity evaluation standard
| The average product score value | Estimate |
| 0～0.49 | Nonirritant |
| 0.5～2.99 | Slight zest |
| 3～5.99 | The moderate zest |
| 6.0～8.0 | Strong and stimulating |
Annotate: the reaction meansigma methods: (erythema forms total points+edema and forms total points)/total number of animals
1.2 exhaust of the influence of red traumatic injury cataplasma single-dose to rabbit intact skin and damaged skin stimulation
Table 7 exhausts the influence that red traumatic injury cataplasma single-dose stimulates the rabbit intact skin
The influence that table 8 cataplasma single-dose stimulates the rabbit damaged skin
1.3 conclusion: rabbit intact skin and the test of damaged skin dose all do not have erythema, edema forms, and skin irritation intensity shows tentatively that less than 0.5 medicine is to the skin nonirritant.
2. exhaust of the influence of red traumatic injury cataplasma multiple dosing to rabbit intact skin and damaged skin stimulation
4 of new zealand purebred rabbits, medicine-feeding part are skin of back, before the medicine 24h with the surgical scissors cropping after; Lose hair or feathers with 8% sodium sulfide; About 15cm * the 10cm of area divides into intact skin check plot, damaged skin check plot, intact skin administration district, 4 zones, damaged skin administration district with the back part of animal depilation at random, and each region area is 7.5cm * 5cm; Epidermis scratches with knife blade, the degree of being with the oozing of blood in damaged skin check plot and damaged skin administration district.Apply and receive reagent thing, substrate in the administration district, once a day, and successive administration 7 days; Behind the last coating 24 hours with warm water cleaning medicine and substrate, in 1h, 24h; 72h observes the dermoreaction situation, observes to have or not erythema, edema, protuberance, burnt silly formation etc., and reference standard is tested with acute irritation; Dermoreaction intensity to every animal is marked, and observes medicine to the skin irritation situation.
Table 9 exhausts red traumatic injury cataplasma successive administration to rabbit skin irritation situation
| Group | 1h | 24h | 48h | 72h |
| The intact skin check plot | 0 | 0 | 0 | 0 |
| The intact skin medicament region | 0 | 0 | 0 | 0 |
| The damaged skin check plot | 0 | 0 | 0 | 0 |
| The damaged skin medicament region | 0 | 0 | 0 | 0 |
Conclusion: the rabbit one or many is coated with after exhausting red traumatic injury cataplasma, skin irritation reactions such as erythema, edema all do not occur, explains that this exhausts red traumatic injury cataplasma is safe.
Experimental example 2
The clinical observation that exhausts red traumatic injury cataplasma treatment closed soft tissue injury of the present invention
1, physical data
Select the closed injury of extremity soft tissue, local pain, swelling, handicapped out-patient 200 examples, at 18～60 years old age, the injured time was the object of observation at 4 days with interior case.The course of disease surpasses 4 days, and the injury skin injury merges except fracture, osteofascial compartment syndrome or other the pathological changes persons.
2, primary symptom criterion
Pain: slight, pain perception is arranged, do not influence routine work with movable; Moderate, pain acid is expanded and is felt, can adhere to routine work and life; Severe, sharp ache is difficult to stand, and influences routine work and life.
Swelling: slight, the colour of skin changes, and the swelling degree is higher than normal skin 1mm～3mm; Moderate, the colour of skin changes, and the swelling degree is higher than between normal skin 4mm～6mm; Severe, the colour of skin changes, and smooth bright or livid purple visible, the swelling degree is higher than normal skin 5mm～10mm.
The functional activity scope: good (+), in more than 1/2 of normal range; In (++), normal range 1/2～1/3 between; Difference (+++), in below 1/3 of normal range.
3, divide into groups
The object of observation is divided into 2 groups at random.120 examples are organized in treatment, use to exhaust red traumatic injury cataplasma treatment affected part, and matched group 80 examples are used 701 DIEDA ZHENTONG GAO treatment affected part, and once a day, be 15 days the full course of treatment.Two groups of patients' situation is following:
Table 10 liang group medication therapentic part distribution situation
| The position | Treatment group (male 83 examples, women 37 examples)/routine number | Matched group (male 55 examples, women 25 examples)/routine number |
| Elbow joint | 8 | 5 |
| Carpal joint | 15 | 9 |
| Knee joint | 32 | 17 |
| Shank | 11 | 6 |
| Ankle joint | 39 | 27 |
| Foot | 15 | 16 |
| Add up to | 120 | 80 |
4, treatment is analyzed
4.1 criterion of therapeutical effect
Recovery from illness: 1 course of treatment of the drug of topical application, pain, swelling disappear, and the movable function scope is normal;
Produce effects: 1 course of treatment of the drug of topical application, pain, swelling obviously alleviate or disappear, and the movable function scope transfers (+) to by (+++);
Effectively: 1 course of treatment of the drug of topical application, pain, swelling alleviate, and the movable function scope transfers (++) to by (+++);
Invalid: 1 course of treatment of the drug of topical application, local symptom does not have improvement.
4.2, efficacy result judges and efficacy assessment standard that according to primary symptom the therapeutic outcome of two groups of cases is added up respectively as follows:
The comparison of average onset time (d) after the table 11 liang group medication (x ± s)
| Symptom and sign | Treatment group (n=120) | Matched group (n=80) | The P value |
| Pain | 1.45±0.60 | ?2.87±0.78 | ＜0.01 |
| Swelling | 2.33±0.80 | ?3.55±0.70 | ＜0.01 |
| Dysfunction | 2.89±0.82 | ?4.30±1.41 | ＜0.01 |
The comparison of table 12 liang group transference cure time (d) (x ± s)
| Symptom and sign | Treatment group (n) | Matched group (n) | The P value |
| Pain | 8.90±1.60(120) | 12.98±1.88(80) | ＜0.01 |
| Swelling | 9.23±1.95(118) | 11.76±2.14(77) | ＜0.01 |
| Dysfunction | 9.38±1.66(108) | 12.05±2.12(53) | ＜0.01 |
Table 13 liang group is soft hinders the total therapeutic outcome of patient relatively
| Group | The example number | Recovery from illness (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| The treatment group | 120 | 78(65.0) | 29(24.2) | 10(8.3) | 2(1.7) | 98.3 |
| Matched group | 80 | 12(15.0) | 18(25.0) | 36(45.0) | 12(15.0) | 85.0 |
Two groups of total effective rates compare, and the treatment group is 98.3%, and matched group is 85.0%, two group to be added up through statistics, and there is significant difference in P＜0.05, two a group total effective rate, explains that treatment group total effective rate is apparently higher than matched group.
Claims (1)
1. the method for preparing of a Jiehong medicine for injuries from falls; This Jiehong medicine for injuries from falls is the cataplasma of being processed by ethanol extraction concentrated solution 44 weight portions of 4400 parts of 4400 parts of 4400 parts of 4400 parts of 4400 parts of 2200 parts of 4400 parts of 4400 parts in 4400 parts on Flos Carthami, catechu, Radix Angelicae Sinensis, Alumens, Lignum Sappans, Aloes, Olibanums, Benzoinumes, the Myrrhas of following weight parts, 4400 parts of Sanguis Draxonis and the receptible host material of pharmaceutics; It is characterized in that this method for preparing comprises: the preparation of (1) ethanol extraction concentrated solution, the preparation of the preparation of (2) host material and (3) cataplasma; Wherein the method for preparing of (1) ethanol extraction concentrated solution is to get Flos Carthami, Lignum Sappan, Radix Angelicae Sinensis to be ground into coarse powder; Adopting percolation, make solvent with 70% ethanol, is slowly percolation of 2ml/min by percolation speed; The ethanol that adds 5 times of amounts of weight is altogether collected percolate; All the other catechu, Alumen, Aloe, Olibanum, Benzoinum, Myrrha, Sanguis Draxonis seven flavors are ground into coarse powder; 70% ethanol that adds 3 times of amounts of medical material, with ultrasonic Treatment twice, two hours for the first time; One hour for the second time; Filtering, is 35% of medical material weight with being evaporated to weight after filtrating and the percolate merging, and the menthol that adds 20 weight portions then mixes; (2) method for preparing of host material is that dihydroxyaluminum aminoacetate, ethylenediaminetetraacetic acid, glycerol and Kaolin is evenly mixed, adds sodium polyacrylate, fully grinds well; Tartaric acid is dissolved in the part distilled water, and gradation joins in the said mixture, stirs; The carbopol adding distil water is dissolved into clear solution, adds again in the said mixture, stir; Add azone, 1 at last, the 2-propylene glycol stirs and promptly gets; (3) method for preparing of cataplasma is that the extracting solution concentrated solution is added in the preparation host material, and stirring grinds well, and this mixture stand is applied on the non-woven fabrics, and horizontal positioned covers upper protective film, and section packs room temperature and places, and gets final product;
Described host material is to be mixed by weight proportion by following material; 0.3 part of 6 parts of sodium polyacrylate, carbopol
980NF2 part, 35 parts of Kaolin, 1.5 parts of ethylenediaminetetraacetic acid, dihydroxyaluminum aminoacetate, 1,5 parts of 2-propylene glycol, 0.2 part in tartaric acid, 35 parts of glycerol, 4 parts of azones, 70 parts of distilled water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910225965XA CN101703667B (en) | 2009-06-03 | 2009-11-21 | Brown red medicament for treating traumatic injuries and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100399504A CN101564487A (en) | 2009-06-03 | 2009-06-03 | Jiehong medicine for injuries from falls and preparation method thereof |
| CN200910039950.4 | 2009-06-03 | ||
| CN200910225965XA CN101703667B (en) | 2009-06-03 | 2009-11-21 | Brown red medicament for treating traumatic injuries and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101703667A CN101703667A (en) | 2010-05-12 |
| CN101703667B true CN101703667B (en) | 2012-10-03 |
Family
ID=42373965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910225965XA Active CN101703667B (en) | 2009-06-03 | 2009-11-21 | Brown red medicament for treating traumatic injuries and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101703667B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071134B (en) * | 2013-01-28 | 2014-07-09 | 广西玉林大金大药业有限公司 | External preparation for treating rheumatic arthrodynia and traumatic pain and swelling and preparation method thereof |
| CN104623167B (en) * | 2015-01-19 | 2018-12-04 | 杨怀强 | It is a kind of for treating the traditional Chinese medicine plaster of neck-shoulder pain, lumbago and leg pain |
| CN105251037A (en) * | 2015-11-19 | 2016-01-20 | 赵岱 | Bandage for treating scalds and preparation method thereof |
-
2009
- 2009-11-21 CN CN200910225965XA patent/CN101703667B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101703667A (en) | 2010-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2362777B1 (en) | Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer | |
| CN101773551B (en) | External-use medicine composition of traditional Mongolian medicine for curing soft tissue injury | |
| CN108186711A (en) | Promote the pharmaceutical composition of wound healing | |
| CN101703667B (en) | Brown red medicament for treating traumatic injuries and preparation method thereof | |
| CN101564487A (en) | Jiehong medicine for injuries from falls and preparation method thereof | |
| CN110974861B (en) | Blumea balsamifera oil liposome | |
| CN103099844B (en) | Traditional Chinese medicinal composition for treating infant eczema | |
| CN115381912A (en) | External traditional Chinese medicine compound preparation for reducing cancer pain and preparation method thereof | |
| CN101744873A (en) | Externally used liquid preparation containing only iridoid glycoside and application thereof | |
| CN110721274B (en) | External antipruritic and preparation method thereof | |
| US11154583B2 (en) | Composition and method of skin relief cream useful for eczema, psoriasis, lipoma, burn wounds, scars, keloids, shingles, dry skin disorders, and skin allergies | |
| CN114177160A (en) | Foot patch for treating dental ulcer and preparation method thereof | |
| ES2932359T3 (en) | Formulation based on N-acetylcysteine and urea for the treatment of dermatological disorders | |
| CN111759905A (en) | Cataplasm for treating osteoarthritis and preparation method thereof | |
| CN1251753C (en) | Externally-applied medicine composition for treating mastoproliferation and its prepn | |
| CN1171628C (en) | Ointment for eliminating macula and its preparation method | |
| CN111658716A (en) | Hydrogel magnetic therapy traditional Chinese medicine plaster and preparation method thereof | |
| CN114246926B (en) | External traditional Chinese medicine composition for treating skin warts and preparation method and application thereof | |
| CN114886981B (en) | Traditional Chinese medicine composition and application thereof in preparation of neck-shoulder lumbocrural pain medicines | |
| CN108853293B (en) | Compound essential oil for treating hemorrhoids and preparation method and use method thereof | |
| CN115463186B (en) | Mongolian medicine emplastrum, preparation method and application thereof | |
| CN116173168B (en) | Sustained-release gel ointment for dispelling wind and cold, relaxing tendons and activating blood circulation, and relieving swelling and pain and preparation method thereof | |
| CN116036225B (en) | A natural external pharmaceutical composition for treating arthritis | |
| CN101940652A (en) | Chinese medicinal liniment for treating psoriasis, multiple kinds of stubborn dermatitis and pruritus | |
| CN104666502A (en) | Traditional Chinese medicine composition for treating eczemas and preparation method for traditional Chinese medicine composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: FENG LIAOXING (FOSHAN) PHARMACEUTICAL CO., LTD. OF Free format text: FORMER NAME: FOSHAN FENGLIAOXING PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: Chancheng District of Guangdong city in Foshan Province, the 528000 Florida Highway No. 35 of Patentee after: Sinopharm group (Foshan) Pharmaceutical Co., Ltd. Address before: Chancheng District of Guangdong city in Foshan Province, the 528000 Florida Highway No. 35 of Patentee before: Foshan Fengliaoxing Pharmaceutical Co., Ltd. |