CN101744873A - Externally used liquid preparation containing only iridoid glycoside and application thereof - Google Patents
Externally used liquid preparation containing only iridoid glycoside and application thereof Download PDFInfo
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- CN101744873A CN101744873A CN200810147750A CN200810147750A CN101744873A CN 101744873 A CN101744873 A CN 101744873A CN 200810147750 A CN200810147750 A CN 200810147750A CN 200810147750 A CN200810147750 A CN 200810147750A CN 101744873 A CN101744873 A CN 101744873A
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Abstract
The invention relates to an externally used liquid preparation containing only iridoid glycoside and application thereof, belonging to the field of medicine. The externally used preparation of the invention contains 0.10-49.99% of the iridoid glycoside as an effective component and balance of adjuvant and water for manufacturing externally used preparations. The formulation of the preparation is externally used liquid lotion, externally used liquid liniment, aerosol, ointment and spraying agent.
Description
Technical field
The present invention relates to a kind of liquid preparation for external application of only iridoid glycoside, particularly relate to a kind of lotion, liniment, aerosol, spray, unguentum of only iridoid glycoside.
Technical background
Traditional analgesic is the opium kind analgesics of representative with the morphine and is the nonsteroidal anti-inflammatory analgetic of representative with the aspirin, but the former has serious adverse reactions such as addiction, respiration inhibition, the latter also has the side effect of infringement gastrointestinal, can not become ideal analgesic.The research of the analgesic of Chinese scholars, low toxicity efficient to seeking from natural drug, no dependence is very active in recent years.
Radix Lamiophlomidis Rotatae Lamiophlomis rotata (Benth.) Kudo is a labiate, belongs to Paraphlomis originally, has now told to become independently from this genus to belong to, and claims Radix Lamiophlomidis Rotatae to belong to, only a kind, have another name called unrivalled logical, Tibetan language also claim " big bus ", " beat cloth cling to ".Its root and rhizome or all herbal medicine are one of national folks such as China Tibetan, illiteracy and Nahsi medical herbs commonly used.Tibetan, illiteracy and Nahsi are among the people flows yellow fluid after being commonly used to treat cutter, gunshot wound, traumatic injury, edema, the medical herbs of illness such as arthritis has the effect of hemostasis and pain-relieving, anti-inflammation, blood circulation promoting and blood stasis dispelling.
Present Radix Lamiophlomidis Rotatae adds starch with the decocting crude extract and makes capsule, is recorded by 2005 editions pharmacopeia, and the Radix Lamiophlomidis Rotatae medical material is also recorded by 2005 editions pharmacopeia, is its evaluation index with flavonoid all.Studies show that. Radix Lamiophlomidis Rotatae contains compositions such as flavone, phenethyl alcohol glycoside, iridoid glycoside.Modern study shows that the Radix Lamiophlomidis Rotatae total iridoid glycosides constituents has good hemostasis, the effect of coagulant blood, is styptic activity composition wherein.
Radix Lamiophlomidis Rotatae dosage form in the market mainly is based on oral medicine, as Radix Lamiophlomidis Rotatae capsule, Radix Lamiophlomidis Rotatae sheet, Radix Lamiophlomidis Rotatae granule etc.Because the shortcoming that oral formulations itself exists, exist dosage greatly, gastrointestinal irritation, easily cause and shortcomings such as alteration of intestinal flora, onset is slow, bioavailability is low, the course of treatment is long, the focus local drug concentration is low can not satisfy Radix Lamiophlomidis Rotatae application clinically.
The iridoid glycoside compounds is the active component of many Chinese medicines, but so far, in patent documentation and the non-patent literature, does not see the report about the liquid preparation for external application of only iridoid glycoside class at home and abroad.
Summary of the invention
The objective of the invention is a kind of liquid preparation for external application that contains iridoid glycoside, it directly acts on the affected part, in the mode of topical, directly acts on the disease position.Compare with oral, medicine is not subjected to the destruction of gastrointestinal PH or enzyme, the destruction of liver first-pass effect in the time of can avoiding oral administration, reduce the influence of medicine to liver, human body is disturbed few, in addition, topical can significantly reduce dosage, improves the focus local drug concentration, reduces toxicity and improves patient's compliance.
Technical scheme of the present invention is: the effective ingredient that contains in the preparation is an iridoid glycoside, and the percentage by weight of only iridoid glycoside is 0.10-49.99%, and its surplus is for making the adjuvant and the water of external preparation.The dosage form of preparation is external use liquid lotion, external use liquid liniment, aerosol, unguentum, spray.The percentage by weight that described liquid lotion, liquid liniment contain iridoid glycoside is the 0.10-49.9% percentage by weight, and the percentage by weight of pastille solvent is 99.90-50.01%.The percentage by weight that contains effective iridoid glycoside in the described aerosol is the 0.10-49.9% percentage by weight, and its surplus is adjuvant solvent, emulsifying agent, propellant, and the percentage by weight that adjuvant contains altogether is 99.90-50.01%.The percentage by weight that contains effective iridoid glycoside in the described unguentum is the 0.10-49.9% percentage by weight, and its surplus is adjuvant solvent, emulsifying agent, and the percentage by weight that adjuvant contains altogether is 99.90-50.01%.The percentage by weight that contains effective iridoid glycoside in the described spray is the 0.10-49.9% percentage by weight, and its surplus is the adjuvant solvent, and the percentage by weight that adjuvant contains altogether is 99.90-50.01%.
The invention discloses the extracting method of four kinds of only iridoid glycosides:
The concrete steps of extracting method 1 are: get the Radix Lamiophlomidis Rotatae medical material, be ground into coarse powder, decoct with water secondary, add the water of 10～30 times of amounts for the first time, decocted 1～2 hour, add the water of 10～20 times of amounts for the second time, decocted 0.5～1.5 hour, merging medicinal liquid, filtration.Get part filtrate and be condensed into thick paste, drying under reduced pressure is ground into fine powder, crosses 200 mesh sieves, and is standby; Residual filtrate is through polyamide column, water and different concentration ethanol eluting, step such as concentrates and further separates, and through differentiating, determines Radix Lamiophlomidis Rotatae total iridoid glycosides.
The step of extracting method 2 is: gets the Radix Lamiophlomidis Rotatae medical material, is ground into coarse powder, decoct with water secondary, add the water of 10～30 times of amounts for the first time, decocted 1～2 hour, add the water of 10～20 times of amounts for the second time, decocted 0.5～1.5 hour, merge medicinal liquid, and filtration, concentrated standby; Concentrated solution is crossed the macropore resin bed analyse post, with 30～50 times of distilled water eluting, collect the part eluent and be condensed into thick paste, drying under reduced pressure is ground into fine powder, crosses 200 mesh sieves, and is standby; Residual filtrate is through polyamide column, water and different concentration ethanol eluting, step such as concentrates and further separates, and through differentiating, determines to obtain Radix Lamiophlomidis Rotatae total iridoid glycosides.
The step of extracting method 3 is: get the Radix Lamiophlomidis Rotatae medical material, be ground into coarse powder, add 70%～99% alcohol reflux 2～3 times, add 8～12 times of amounts of ethanol for the first time, refluxed 1～3 hour, add 6～10 times of amounts of ethanol, refluxed 1～2 hour for the 2nd, 3 time; Merge backflow, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, obtains the alcohol extraction concentrated solution; After the alcohol extraction concentrated solution adds the water suspendible, use petroleum ether, n-butanol extraction 2～3 times successively, reclaim solvent, drying obtains ligroin extraction A, n-butanol extract B, and extracting remainder is water extract C.Through differentiating that n-butanol extract B is a Radix Lamiophlomidis Rotatae total iridoid glycosides.
The step of extracting method 4 is: get the Radix Lamiophlomidis Rotatae medical material, be ground into coarse powder, put in the percolator, with 70%～90% soak with ethanol after 12～36 hours, with 5ml～10ml/min speed percolation, until reserving liquid till thin layer chromatography detects immaculate; Concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, obtains the Radix Lamiophlomidis Rotatae percolate; The Radix Lamiophlomidis Rotatae percolate is added water left standstill 12～36 hours, obtain precipitate A; Supernatant is crossed the macropore resin bed and is analysed post, uses 30～50 times of distilled water respectively, and 30～50 times of 15%～45% ethanol elution reclaims ethanol, and drying obtains extract B, C; Through identifying that extract C is a Radix Lamiophlomidis Rotatae total iridoid glycosides.
The purposes that the present invention contains the liquid preparation for external application of iridoid glycoside is a promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Be used for osteopatia sprain, soft tissue injury.
The used solvent of the present invention is water, ethanol, Polyethylene Glycol, 1,2 one propylene glycol, ethylene glycol one or more with arbitrarily than blended mixture.
The used emulsifying agent of the present invention is a tween 80, polyoxyethylene alkyl ether, sodium stearyl sulfate one or more with arbitrarily than blended mixture.
The used substrate of the present invention be glycerin gelatine, sodium carboxymethyl cellulose, carbopol, Polyethylene Glycol one or more with arbitrarily than blended mixture.
The used propellant of the present invention is that in isceon, dichlorodifluoromethane, Dichlorotetrafluoromethane, the tetrafluoroethane one or more are with arbitrarily than blended mixture.
The present invention makes external use liquid lotion, external use liquid liniment, aerosol, unguentum, spray with the total iridoid glycoside in the Radix Lamiophlomidis Rotatae.Have that dosage is little, rapid-action, focus local drug concentration height, toxicity is little, production cost is low, easy to use, advantage such as patient's compliance is good.
The specific embodiment
By specific embodiment given below and experimental data material, can further be well understood to liquid preparation for external application of the present invention and uses thereof.But they are not limitation of the invention.
Embodiment 1 Radix Lamiophlomidis Rotatae total iridoid glycosides is washed the embodiment of (wiping) agent
1) prescription (every 100ml consumption)
Radix Lamiophlomidis Rotatae total iridoid glycosides 0.1g (0.1%)
Sterilized water 99.9g (99.9%)
2) method for making: the Radix Lamiophlomidis Rotatae total iridoid glycosides of the consumption of will filling a prescription is soluble in water, mixing.
Embodiment 2 Radix Lamiophlomidis Rotatae total iridoid glycosides are washed the embodiment of (wiping) agent
1) prescription (every 100ml consumption)
Radix Lamiophlomidis Rotatae total iridoid glycosides 2g (2.0%)
Sterilized water 98g (98.0%)
2) method for making: the Radix Lamiophlomidis Rotatae total iridoid glycosides of the consumption of will filling a prescription is soluble in water, mixing.
Embodiment 3 Radix Lamiophlomidis Rotatae total iridoid glycosides are washed the embodiment of (wiping) agent
1) prescription (every 100ml consumption)
Radix Lamiophlomidis Rotatae total iridoid glycosides 49.99g (49.99.0%)
Sterilized water 50.01g (50.01%)
2) method for making: the Radix Lamiophlomidis Rotatae total iridoid glycosides of the consumption of will filling a prescription is soluble in water, mixing.
Embodiment 4 Radix Lamiophlomidis Rotatae total iridoid glycosides ointment embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 0.1g (0.1%)
Gelatin 3.0g (3.0%)
Glycerol 30.0g (30.0%)
Water 66.9g (66.9%)
2) method for making: each supplementary material weighing of the consumption of will filling a prescription, dissolve, packing behind the mixing, packing.
Embodiment 5 Radix Lamiophlomidis Rotatae total iridoid glycosides ointment embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 49.9g (49.9%)
Macrogol 4000 10.0g (10.0%)
PEG400 30.0g (30.0%)
Water 10.1g (10.1%)
2) method for making: each supplementary material weighing of the consumption of will filling a prescription, dissolve, packing behind the mixing, packing.
Embodiment 6 Radix Lamiophlomidis Rotatae total iridoid glycosides ointment embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 2.0g (2.0%)
Carbopol 940 10.0g (10.0%)
Ethanol 5.0g (5.0%)
Glycerol 5.0g (5.0%)
Water 88.0g (88.0%)
2) method for making: each supplementary material weighing of the consumption of will filling a prescription, dissolve, packing behind the mixing, packing.
Embodiment 7 Radix Lamiophlomidis Rotatae total iridoid glycosides collutory embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 0.1g (0.1%)
Water 99.9g (99.85%)
Oleum menthae 0.05g (0.05%)
2) method for making: will fill a prescription each supplementary material weighing, dissolving, mixing.
Embodiment 8 Radix Lamiophlomidis Rotatae total iridoid glycosides collutory embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 49.9g (49.9%)
Water 50.1g (50.05%)
Oleum Rosae Rugosae 0.05g (0.05%)
2) method for making: will fill a prescription each supplementary material weighing, dissolving, mixing.
Embodiment 9 Radix Lamiophlomidis Rotatae total iridoid glycosides collutory embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 2.0g (2.0%)
Water 98.1g (97.95%)
Oleum Caryophylli 0.05g (0.05%)
2) method for making: will fill a prescription each supplementary material weighing, dissolving, mixing.
Embodiment 10 Radix Lamiophlomidis Rotatae total iridoid glycosides foam aerosol embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 0.1g (2.0%)
1,2-propylene glycol 10.4g (10.4%)
Ethylene glycol 16.7g (16.7%)
Dichlorodifluoromethane (F
12) 7.0g (7.0%)
Purified water 65.8g (65.8%)
2) method for making: except that dichlorodifluoromethane, will fill a prescription each supplementary material weighing, dissolving, mixing, packing pour into dichlorodifluoromethane, promptly at last.
Embodiment 11 Radix Lamiophlomidis Rotatae total iridoid glycosides foam aerosol embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 49.9g (49.9%)
1,2-propylene glycol 10.4g (10.4%)
Ethylene glycol 16.7g (16.7%)
Dichlorodifluoromethane (F
12) 7.0g (7.0%)
Purified water 15.5g (15.5%)
2) method for making: except that dichlorodifluoromethane, will fill a prescription each supplementary material weighing, dissolving, mixing, packing pour into dichlorodifluoromethane, promptly at last.
Embodiment 12 Radix Lamiophlomidis Rotatae total iridoid glycosides foam aerosol embodiments
1) prescription
Radix Lamiophlomidis Rotatae total iridoid glycosides 49.9g (49.9%)
1,2-propylene glycol 10.4g (10.4%)
Ethylene glycol 16.7g (16.7%)
Dichlorodifluoromethane (F
12) 7.0g (7.0%)
Purified water 15.5g (15.5%)
2) method for making: except that dichlorodifluoromethane, will fill a prescription each supplementary material weighing, dissolving, mixing, packing pour into dichlorodifluoromethane, promptly at last.
Embodiment 13 Radix Lamiophlomidis Rotatae total iridoid glycosides spray embodiments
Radix Lamiophlomidis Rotatae total iridoid glycosides 0.1g (0.1%)
Sterilized water 99.9g (99.9%)
2) method for making: will fill a prescription each supplementary material weighing, dissolving, mixing.
Embodiment 14 Radix Lamiophlomidis Rotatae total iridoid glycosides spray embodiments
Radix Lamiophlomidis Rotatae total iridoid glycosides 49.9g (49.9%)
Sterilized water 50.1g (50.1%)
2) method for making: will fill a prescription each supplementary material weighing, dissolving, mixing.
Embodiment 15 Radix Lamiophlomidis Rotatae total iridoid glycosides spray embodiments
Radix Lamiophlomidis Rotatae total iridoid glycosides 2g (2.0%)
Sterilized water 98g (98.0%)
2) method for making: will fill a prescription each supplementary material weighing, dissolving, mixing.
The pharmacodynamics test of Radix Lamiophlomidis Rotatae total iridoid series of products of the present invention is as follows:
The Radix Lamiophlomidis Rotatae total iridoid glycosides spray, lot number: 20080601; Be dissolved into the test liquid that contains principal agent 10mg/ml with sterilized water.
This product is an external preparation, be subjected to the reagent thing by observer's rabbit skin contact after, the irritant reaction that is produced is investigated the zest of this preparation to body; Cause the effect of mice pain and, investigate the drug effect of spray of the present invention by acetic acid the mice experiments such as influence in docking bleeding time.
One, skin irritation test
1.1 the processing of animal subject
(2.1 ± 0.2kg) 8, male and female half and half are divided into intact skin group and damaged skin group to get healthy rabbits.In administration preceding 48 hours, with 10% sodium sulfide solution animal spinal column diamond wool to be taken off, every area is about 50cm
2, checked after the unhairing that skin of unhairing is whether injured because of unhairing in 24 hours.The making of damaged skin is scratched the unhairing skin of sterilizing with scalpel, the degree of being with the oozing of blood, and the damaged degree of control left and right sides skin is consistent substantially.
1.2 test method
Consubstantiality left and right sides Self-control method is adopted in test.Left and right side unhairing district sprays respectively and gives lot number is 20080601 Radix Lamiophlomidis Rotatae total iridoid glycosides spray and blank microemulsion 2ml.Every day secondary, one week of successive administration, in the 8th day with residual reagent thing and the blank microemulsion of being subjected to of warm water flush away.Have or not situations such as erythema and edema respectively at 1,24,48,72 hour observation medicine-feeding part after removing medicine, notice simultaneously whether observe the spreader portion position has situations such as pigmentation, petechia, pachylosis or epidermatic atrophy, record generation and recovery situation, time, mark.Result of the test sees Table 1.
Table 1 spray rabbit irritation test result (n=4)
The result shows, after the Radix Lamiophlomidis Rotatae total iridoid glycosides spray medication for three days on end among the present invention, observes in 7 hours, and rabbit intact skin group is not found anaphylactic reactions such as erythema, edema.And the damaged skin group has a small amount of erythema to form, and damage location edema phenomenon, the more serious edema of indivedual appearance, erythema can disappear after 72 hours or alleviate gradually, the edema degree also can alleviate, total stimulation degree score value between 2.00-4.00, light to moderate stimulation.Illustrate that the Radix Lamiophlomidis Rotatae total iridoid glycosides spray has no stimulation to the rabbit intact skin, damaged skin is had slight stimulation, anaphylactic reactions such as a small amount of erythema, Mild edema can occur.
Two, Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction
Choose 60 of healthy mices, male and female half and half, be divided into 6 groups at random by body weight, be respectively normal saline group, positive controls (acetaminophen 0.23g/kg body weight), Radix Lamiophlomidis Rotatae capsule, vegetable oil matched group, osteopatia sprain spirit spray (Guangxi Guixi Pharmaceutical Co., Ltd), Radix Lamiophlomidis Rotatae total iridoid glycosides spray, 10 every group.The every Mus oral administration gavage of normal saline group normal saline 10ml/kg body weight, the every Mus oral administration gavage of positive controls positive control drug, the every Mus oral administration gavage of Radix Lamiophlomidis Rotatae capsule group Radix Lamiophlomidis Rotatae capsule (specification: the 0.3g/ grain), lot number 071117 faces with preceding and is mixed with debita spissitudo (according to the preparation of 2005 editions official methods) with normal saline; Vegetable oil matched group, osteopatia sprain spirit spray and Radix Lamiophlomidis Rotatae total iridoid glycosides spray shave off the mouse web portion hair before experiment, be coated with corresponding medicinal liquid of 0.1ml or vegetable oil with mouse web portion.Repeat coating respectively once after 1 hour.Then immediately at above 6 treated animal lumbar injections, 0.7% acetum 0.1ml/10g, observe the pain writhing response of mice, stretch with typical hind leg, the abdominal part distortion, abdominal muscle is punctured into standard, and that writes down each treated animal in 15 minutes turns round the body number of times.Result of the test is as follows, with T check carrying out statistical analysis.
Table 2 spray Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction
Compare with negative control group: p
*＜0.05, p
*＜0.01
Conclusion: show that Radix Lamiophlomidis Rotatae total iridoid glycosides spray of the present invention has significant analgesic activity.
Claims (10)
1. a liquid preparation for external application that contains Radix Lamiophlomidis Rotatae is characterized in that the effective ingredient that contains in the preparation is an iridoid glycoside, and the percentage by weight of only iridoid glycoside is 0.10-49.99%, and its surplus is for making the adjuvant and the water of external preparation.
2. a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae according to claim 1, the dosage form that it is characterized in that said preparation are external use liquid lotion, external use liquid liniment, aerosol, unguentum, spray.
3. a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae according to claim 2, wherein liquid lotion, liquid liniment are characterised in that by the percentage by weight that contains iridoid glycoside be the 0.10-49.9% percentage by weight, and the percentage by weight of pastille solvent is 99.90-50.01%.
4. a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae according to claim 2, wherein aerosol is characterised in that the percentage by weight that contains effective iridoid glycoside is the 0.10-49.9% percentage by weight, its surplus is adjuvant solvent, emulsifying agent, propellant, and the percentage by weight that adjuvant contains altogether is 99.90-50.01%.
5. a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae according to claim 4, propellant wherein are meant that in isceon, dichlorodifluoromethane, Dichlorotetrafluoromethane, the tetrafluoroethane one or more are with arbitrarily than blended mixture.
6. a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae according to claim 2, wherein unguentum is characterised in that the percentage by weight that contains effective iridoid glycoside is the 0.10-49.9% percentage by weight, its surplus is adjuvant solvent, emulsifying agent, substrate, and the percentage by weight that adjuvant contains altogether is 99.90-50.01%.
7. a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae according to claim 6, its mesostroma be meant glycerin gelatine, sodium carboxymethyl cellulose, carbopol, Polyethylene Glycol one or more with arbitrarily than blended mixture.
8. a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae according to claim 2, wherein spray is characterised in that the percentage by weight that contains effective iridoid glycoside is the 0.10-49.9% percentage by weight, its surplus is the adjuvant solvent, and the percentage by weight that adjuvant contains altogether is 99.90-50.01%.
9. according to the described a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae of arbitrary claim among the claim 3-8, adjuvant solvent wherein is water, ethanol, Polyethylene Glycol, 1, the 2-propylene glycol, ethylene glycol one or more with arbitrarily than blended mixture.
10. according to the described a kind of liquid preparation for external application that contains Radix Lamiophlomidis Rotatae of claim in claim 4 or 6, emulsifying agent wherein is meant tween 80, polyoxyethylene alkyl ether, sodium stearyl sulfate one or more with arbitrarily than blended mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN200810147750A CN101744873A (en) | 2008-12-02 | 2008-12-02 | Externally used liquid preparation containing only iridoid glycoside and application thereof |
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|---|---|---|---|
| CN200810147750A CN101744873A (en) | 2008-12-02 | 2008-12-02 | Externally used liquid preparation containing only iridoid glycoside and application thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432195A (en) * | 2013-07-03 | 2013-12-11 | 张泉龙 | Method for one step separation and purification of the total iridoid glycoside component in lamiophlomis rotata by using active carbon chromatograph column |
| CN104586948A (en) * | 2014-10-20 | 2015-05-06 | 恒康医疗集团股份有限公司 | Oral care composition, oral care solution containing same and preparation method of oral care solution |
| CN106589009A (en) * | 2016-12-08 | 2017-04-26 | 中国科学院西北高原生物研究所 | Preparation method of Phlorigidoside C natural product standard substance in lamiophlomis rotata and application thereof |
| CN107823470A (en) * | 2017-11-10 | 2018-03-23 | 中国药科大学 | One kind is containing genuine Tibetan herbal medicine lamiophlomis rotata ointment formulations, preparation method and its usage |
-
2008
- 2008-12-02 CN CN200810147750A patent/CN101744873A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432195A (en) * | 2013-07-03 | 2013-12-11 | 张泉龙 | Method for one step separation and purification of the total iridoid glycoside component in lamiophlomis rotata by using active carbon chromatograph column |
| CN104586948A (en) * | 2014-10-20 | 2015-05-06 | 恒康医疗集团股份有限公司 | Oral care composition, oral care solution containing same and preparation method of oral care solution |
| CN106589009A (en) * | 2016-12-08 | 2017-04-26 | 中国科学院西北高原生物研究所 | Preparation method of Phlorigidoside C natural product standard substance in lamiophlomis rotata and application thereof |
| CN106589009B (en) * | 2016-12-08 | 2019-05-21 | 中国科学院西北高原生物研究所 | Phlorigidoside C natural products standard items preparation method and applications in lamiophlomis rotata |
| CN107823470A (en) * | 2017-11-10 | 2018-03-23 | 中国药科大学 | One kind is containing genuine Tibetan herbal medicine lamiophlomis rotata ointment formulations, preparation method and its usage |
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Open date: 20100623 |