CN102697835B - The topical agent for the treatment of disease of skin - Google Patents
The topical agent for the treatment of disease of skin Download PDFInfo
- Publication number
- CN102697835B CN102697835B CN201210234682.3A CN201210234682A CN102697835B CN 102697835 B CN102697835 B CN 102697835B CN 201210234682 A CN201210234682 A CN 201210234682A CN 102697835 B CN102697835 B CN 102697835B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- weight portions
- weight
- topical agent
- portions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of topical agent for the treatment of disease of skin. Particularly; the present invention relates to a kind of topical agent; it comprises medicinal material and the drug matrices of following component, or it is made up of the medicinal material and the drug matrices that comprise following component: cinnabar, calamine, borneol, frankincense, myrrh, rosin, castor oil, gypsum (forging), camphor, calculus bovis factitius, pearl. The invention still further relates to the purposes of described topical agent drug regimen and the preparation method of described topical agent. Topical agent of the present invention can be used for the treatment of disease of skin such as whelk, dark sore, acne etc. effectively.
Description
Technical field
The present invention relates to medical technical field, relate to a kind of topical agent for the treatment of disease of skin, particularly one is controlledTreat the topical agent for the treatment of whelk, dark sore, acne. Specifically, this topical agent can be applied to the heap soil or fertilizer over and around the roots of fire poison and contain, furuncle sorePoison, red and swollen heat pain, purulence is not held back person etc. after becoming not routed and stain, is especially applicable to the skin sore class illnesss such as whelk, dark sore, acne. ThisInvention also relates to the preparation method of this topical agent.
Background technology
Acne is commonly called as " whelk ", is again " pimples ", " acne ", " acne ", " dark sore " etc., is modal hair follicle sebumThe chronic inflammation dermatoses of gland. Because of the obstruction of sebaceous gland duct and pore, due to sebum outflow is not smooth. After adolescence,Almost everyone can on the face or other positions gave birth to acne, just some people's quantity is few, the time is short, generally after 25 years oldNaturally trend recovery from illness, so needn't be present to the mind; Somebody's quantity is many, shows as papule, blackhead, warts, abscess, tubercle, capsuleSwollen, even scar, often hinders attractive in appearance. Somebody seeks medical advice or own random controlling carelessly, so that sb.'s illness took a turn for the worse, produces more scar,Regret to the very end of one's life.
Acne is a kind of multifactor disease causing, under the condition that has inherent cause, 3male hormone secretion increases (especiallyThat protona in skin histology increases) and follicular orifice in the effect of the microorganism such as bacillus acnes be pathogenesis of acneTwo principal elements. The growth of human body sebaceous glands and sebum secretion are directly subject to the domination of male sex hormone, and swash puberty due to maleElement level significantly improves, and stimulates sebaceous glands, makes sebum secretion dysfunction active, and sebum is secreted in a large number, makes skin glossy shinny,Follicular orifice also expands thereupon, and because the angling of pilosebaceous duct or follicular orifice is stopped up, too much sebum can not be discharged in time,The stasis of blood is amassed and in hair follicle, is formed fat bolt, i.e. so-called acne. Dissolved lipase, protease and hyalomitome that bacillus acnes producesAcid enzyme can decompose the triglyceride in sebum, become free fatty, it can destroy follicular wall, make hair follicle inclusion enter andStimulate corium and hair follicle surrounding tissue, cause pilosebaceous follicle inflammatory reaction around, cause a series of acne symptoms. Part purulenceBlister is the scabies secondary infection due to demodex folliculorum parasitism or staphylococcus albus.
In the multiple crowd who is born in adolescence or Oily of whelk (acne, acne). There is face at the good position of sending outCheek, lower jaw and forehead, also see shirtfront or back. What have is grain of rice shape, and what have is warts sample, and outbreak is repeatedly difficult to cure. EspeciallyIt is long in facial acne, has not only had a strong impact on attractive in appearancely, and caused mentally pressure to young people, produces to feel oneself inferiorPsychology, even directly affects work, studying and living.
Modern medicine thinks that the genesis mechanism of acne and reason mainly contain the following aspects: 1, puberty hormone secretion mistakeMany, sebum secretion is hyperfunction, produces excessive grease, aliphatic acid, causes sebaceous glands not smooth, and hair follicle tube wall angling material increases and hindersPlug hair follicle hole, causes inflammation, and forms acne. 2, it is (main that hair follicle obstruction makes local bacterium amount reproduction under the condition of anaerobismBacillus acnes or staphylococcus albus), cause suppurative folliculitis, i.e. whelk (acne, acne). 3, because individual losesThe effect of biography factor, how much relevant sebaceous glands size, quantity and secretion be. Eat the food of higher fatty acid or pungent stimulation, to skinThe secretion of sebaceous glands has a certain impact, and makes hair follicle secretion not smooth, forms whelk (acne, acne). 4, medicine also can drawPlay whelk (acne, acne), as steroids or VAD. 5, puberty women menstrual cycle, hormone in vivo levelVariation has occurred, and smegma disorder can make whelk (acne, acne) increase the weight of. 6, due to extraneous factor, as made for a long timeWith containing the cosmetics that lanolin or vaseline are raw material, the normal excretion of blocking hair follicle; Airborne dust, harmful substance adhere toOn skin, do not remove and clean in time, block hair follicle and form whelk (acne, acne).
At present, be used for the treatment of the dermopathic external application chemical drug class plaster such as whelk, dark sore, acne various in style, but chemicalMedicine because of the drawbacks limit such as curative effect and toxic and side effect its apply clinically. Traditional Chinese medicine plaster has unique clinical efficacy and lowerToxic and side effect, is subject to doctor and patient's favor deeply. But the traditional Chinese medicine plaster preparation that can really be applied at present clinical treatment is very deficientWeary, and mostly be the prescription spreading, lacking scientific appraisal, curative effect is also imprecise, easily causes the state of an illness to incur loss through delay.
Therefore, this area needs effectively to treat the dermopathic medicine use taking whelk, dark sore, acne etc. as representativeIn clinical.
Summary of the invention
The object of the invention is to for the problems referred to above, provide being used for the treatment of with whelk, dark of a kind of novelty for clinicalThe dermopathic topical agent that sore, acne etc. are representative. The inventor finds that one comprises the components such as cinnabar, calamine, borneolThe topical agent of preparation has advantages of evident in efficacy, cheap, safe for above-mentioned skin disease.
For this reason, the object of first aspect present invention be to provide one can be effective to treat and/or prevent with whelk,The dermopathic topical agent that dark sore, acne etc. are representative. The object of a second aspect of the present invention is to provide the above-mentioned external application of preparationThe method of medicament. The object of third aspect present invention be to provide above-mentioned a kind of Chinese traditional medicine composition for the preparation for the treatment of skin disease for examplePurposes in the topical agent of whelk, dark sore, acne.
Particularly, first aspect present invention provides a kind of topical agent, and this topical agent can be used for treating and/or preventingDisease of skin is whelk, dark sore, acne etc. such as. Particularly, first aspect present invention provides a kind of topical agent, and it comprisesTen medicinal material and drug matrices simply of following component, or it is by ten medicinal material and the drug matrices systems simply that comprise following componentBecome: cinnabar, calamine, borneol, frankincense, myrrh, rosin, castor oil, gypsum (forging), camphor, calculus bovis factitius, pearl.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and calamine amount is 20-160 weight portions, for example 30-120 weight portion, for example 40-100 weight portion, for example 50-80 weight portion, for example approximately 50 weight portions, approximately63 weight portions or approximately 78 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and borneol amount is 25-125Weight portion, for example 50-100 weight portion, for example 60-80 weight portion, for example 65-75 weight portion, for example approximately 66 weight portions, approximately 70 weightsAmount part or approximately 74 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and frankincense amount is 10-80Weight portion, for example 15-60 weight portion, for example 20-50 weight portion, for example 20-35 weight portion, for example approximately 21 weight portions, approximately 25 weightsAmount part or approximately 33 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and not having dose is 10-75Weight portion, for example 20-50 weight portion, for example 25-40 weight portion, for example 25-35 weight portion, for example approximately 28 weight portions, approximately 30 weightsAmount part or approximately 32 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and rosin amount is 50-160Weight portion, for example 70-140 weight portion, for example 80-125 weight portion, for example 85-110 weight portion, for example approximately 84 weight portions, approximately 90Weight portion or approximately 110 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and castor-oil plant oil mass is 20-90 weight portions, for example 30-75 weight portion, for example 35-60 weight portion, for example 40-45 weight portion, for example approximately 40 weight portions, approximately 42Weight portion or approximately 44 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and gypsum (forging) amount is10-80 weight portion, for example 15-50 weight portion, for example 25-40 weight portion, for example 25-35 weight portion, for example approximately 26 weight portions, approximately30 weight portions or approximately 31 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and camphor amount is 20-120Weight portion, for example 30-100 weight portion, for example 40-90 weight portion, for example 50-75 weight portion, for example approximately 50 weight portions, approximately 66 weightsAmount part or approximately 74 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and calculus bovis factitius amount is0.5-10 weight portion, for example 1-5 weight portion, for example 1.25-4 weight portion, for example 1.5-3.5 weight portion, for example approximately 1.5 weightPart, approximately 2.1 weight portions or approximately 3.3 weight portions.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and pearl amount is 0.5-10Weight portion, for example 1-5 weight portion, for example 1.5-4 weight portion, for example 2-3 weight portion, for example approximately 2 weight portions, approximately 2.5 weight portions,Or approximately 2.7 weight portion.
According to the topical agent of first aspect present invention, in its medicinal material, cinnabar is in 200 weight portions, and drug matrices amount is200-850 weight portion, for example 300-750 weight portion, for example 400-650 weight portion, for example 450-600 weight portion.
According to the topical agent of first aspect present invention, wherein said drug matrices is oleaginous base. An enforcement sideIn case, described drug matrices is selected from following one or more: lanolin, vaseline, paraffin, yellow wax, tristearin, natural rubber,Atoleine.
According to the topical agent of first aspect present invention, wherein said drug matrices comprises lanolin, Zhu in its medicinal materialSand is in 200 weight portions, and lanolin amount is 5-50 weight portion, for example 7.5-40 weight portion, for example 10-30 weight portion, for example 15-25 weight portions, for example approximately 16 weight portions, approximately 17 weight portions or approximately 22 weight portions. According to the topical agent of first aspect present invention,Wherein said drug matrices comprises vaseline, and in its medicinal material, cinnabar is in 200 weight portions, and vaseline amount is 200-800 weightPart, for example 300-700 weight portion, for example 400-600 weight portion, for example 425-550 weight portion, for example approximately 420 weight portions, approximately480 weight portions or approximately 540 weight portions.
According to the topical agent of first aspect present invention, comprising:
| Cinnabar | 200 weight portions, |
| Calamine | 20-160 weight portion, |
| Borneol | 25-125 weight portion, |
| Frankincense | 10-80 weight portion, |
| Myrrh | 10-75 weight portion, |
| Rosin | 50-160 weight portion, |
| Castor oil | 20-90 weight portion, |
| Gypsum (forging) | 10-80 weight portion, |
| Camphor | 20-120 weight portion, |
| Calculus bovis factitius | 0.5-10 weight portion, |
| Pearl | 0.5-10 weight portion, |
| Drug matrices | 200-850 weight portion. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabar | 200 weight portions, 3 --> |
| Calamine | 30-120 weight portion, |
| Borneol | 50-100 weight portion, |
| Frankincense | 15-60 weight portion, |
| Myrrh | 20-50 weight portion, |
| Rosin | 70-140 weight portion, |
| Castor oil | 30-75 weight portion, |
| Gypsum (forging) | 15-50 weight portion, |
| Camphor | 30-100 weight portion, |
| Calculus bovis factitius | 1-5 weight portion, |
| Pearl | 1-5 weight portion, |
| Drug matrices | 300-750 weight portion. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabar | 200 weight portions, |
| Calamine | 40-100 weight portion, |
| Borneol | 60-80 weight portion, |
| Frankincense | 20-50 weight portion, |
| Myrrh | 25-40 weight portion, |
| Rosin | 80-125 weight portion, |
| Castor oil | 35-60 weight portion, |
| Gypsum (forging) | 25-40 weight portion, |
| Camphor | 40-90 weight portion, |
| Calculus bovis factitius | 1.25-4 weight portion, |
| Pearl | 1.5-4 weight portion, |
| Drug matrices | 400-650 weight portion. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabar | 200 weight portions, |
| Calamine | 50-80 weight portion, |
| Borneol | 65-75 weight portion, |
| Frankincense | 20-35 weight portion, |
| Myrrh | 25-35 weight portion, |
| Rosin | 85-110 weight portion, |
| Castor oil | 40-45 weight portion, |
| Gypsum (forging) | 25-35 weight portion, |
| Camphor | 50-75 weight portion, |
| Calculus bovis factitius | 1.5-3.5 weight portion, |
| Pearl | 2-3 weight portion, 4 --> |
| Drug matrices | 450-600 weight portion. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabar | 180 weight portions, |
| Calamine | 70 weight portions, |
| Borneol | 60 weight portions, |
| Frankincense | 30 weight portions, |
| Myrrh | 25 weight portions, |
| Rosin | 100 weight portions, |
| Castor oil | 40 weight portions, |
| Gypsum (forging) | 28 weight portions, |
| Camphor | 60 weight portions, |
| Calculus bovis factitius | 3 weight portions, |
| Pearl | 2.4 weight portions, |
| Lanolin | 20 weight portions, |
| Vaseline | 490 weight portions. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabar | 190 weight portions, |
| Calamine | 60 weight portions, |
| Borneol | 70 weight portions, |
| Frankincense | 20 weight portions, |
| Myrrh | 30 weight portions, |
| Rosin | 80 weight portions, |
| Castor oil | 40 weight portions, |
| Gypsum (forging) | 25 weight portions, |
| Camphor | 70 weight portions, |
| Calculus bovis factitius | 2.0 weight portions, |
| Pearl | 2.4 weight portions, |
| Lanolin | 15 weight portions, |
| Vaseline | 460 weight portions. |
According to the topical agent of first aspect present invention, comprising:
| Cinnabar | 200 weight portions, |
| Calamine | 50 weight portions, |
| Borneol | 70 weight portions, |
| Frankincense | 25 weight portions, |
| Myrrh | 30 weight portions, 5 --> |
| Rosin | 90 weight portions, |
| Castor oil | 40 weight portions, |
| Gypsum (forging) | 30 weight portions, |
| Camphor | 50 weight portions, |
| Calculus bovis factitius | 1.5 weight portions, |
| Pearl | 2.0 weight portions, |
| Lanolin | 17 weight portions, |
| Vaseline | 420 weight portions. |
According to the topical agent of first aspect present invention, wherein said each medicinal material is to join institute through the method for physical treatmentState in topical agent.
According to the topical agent of first aspect present invention, wherein said each medicinal material is to add through the method for physical crushing processingTo in described topical agent. In one embodiment, described physical crushing can be to be selected from following mode: water flies, machineTool is pulverized, is ground and combination.
According to the topical agent of first aspect present invention, it is to be to be selected from following medicine type: plaster, ointment, hardPaste, cream, paste, lotion, paint, patch, gel, liniment, spray, emplastrum.
According to the topical agent of first aspect present invention, in its every 1000g, comprising crude drug total amount is 100-900g, for example200-800g, for example 300-700g, for example 400-700g, for example 500-700g, for example about 500g, for example 600g, for example approximately700g。
According to the composition of first aspect present invention, it is the medicament of ointment.
According to the topical agent of first aspect present invention, it is the medicament of plaster. In one embodiment, described plasterBe to be spread onto in framed back material and made by the topical agent of first aspect present invention, it is the external application system that can stick for skinAgent.
Second aspect present invention provides being combined in for the preparation for the treatment of and/or preventing skin disease case of following traditional Chinese medicines materialPurposes as in the topical agent of the illnesss such as whelk, dark sore, acne: cinnabar, calamine, borneol, frankincense, myrrh, rosin, castorSesame oil, gypsum (forging), camphor, calculus bovis factitius, pearl.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and calamine amount is 20-160 weight portions, for example 30-120 weight portion, for example 40-100 weight portion, for example 50-80 weight portion, for example approximately 50 weight portions, approximately63 weight portions or approximately 78 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and borneol amount is 25-125Weight portion, for example 50-100 weight portion, for example 60-80 weight portion, for example 65-75 weight portion, for example approximately 66 weight portions, approximately 70 weightsAmount part or approximately 74 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and frankincense amount is 10-80Weight portion, for example 15-60 weight portion, for example 20-50 weight portion, for example 20-35 weight portion, for example approximately 21 weight portions, approximately 25 weightsAmount part or approximately 33 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and not having dose is 10-75Weight portion, for example 20-50 weight portion, for example 25-40 weight portion, for example 25-35 weight portion, for example approximately 28 weight portions, approximately 30 weightsAmount part or approximately 32 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and rosin amount is 50-160Weight portion, for example 70-140 weight portion, for example 80-125 weight portion, for example 85-110 weight portion, for example approximately 84 weight portions, approximately 90Weight portion or approximately 110 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and castor-oil plant oil mass is 20-90 weight portions, for example 30-75 weight portion, for example 35-60 weight portion, for example 40-45 weight portion, for example approximately 40 weight portions, approximately 42Weight portion or approximately 44 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and gypsum (forging) amount is10-80 weight portion, for example 15-50 weight portion, for example 25-40 weight portion, for example 25-35 weight portion, for example approximately 26 weight portions, approximately30 weight portions or approximately 31 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and camphor amount is 20-120Weight portion, for example 30-100 weight portion, for example 40-90 weight portion, for example 50-75 weight portion, for example approximately 50 weight portions, approximately 66 weightsAmount part or approximately 74 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and calculus bovis factitius amount is0.5-10 weight portion, for example 1-5 weight portion, for example 1.25-4 weight portion, for example 1.5-3.5 weight portion, for example approximately 1.5 weightPart, approximately 2.1 weight portions or approximately 3.3 weight portions.
According to the purposes of second aspect present invention, in described Chinese medicine, cinnabar is in 200 weight portions, and pearl amount is 0.5-10Weight portion, for example 1-5 weight portion, for example 1.5-4 weight portion, for example 2-3 weight portion, for example approximately 2 weight portions, approximately 2.5 weight portions,Or approximately 2.7 weight portion.
According to the purposes of second aspect present invention, in described topical agent, also comprise drug matrices. Described topical agentIn medicinal material, cinnabar is in 200 weight portions, and drug matrices amount is 200-850 weight portion, for example 300-750 weight portion, for example 400-650 weight portions, for example 450-600 weight portion. According to the purposes of second aspect present invention, wherein said drug matrices is oiliness baseMatter. In one embodiment, described drug matrices is selected from following one or more: lanolin, vaseline, paraffin, yellow wax,Tristearin, natural rubber, atoleine.
According to the purposes of second aspect present invention, the described drug matrices of described topical agent comprises lanolin, medicinal materialMiddle cinnabar is in 200 weight portions, and lanolin amount is 5-50 weight portion, for example 7.5-40 weight portion, for example 10-30 weight portion, exampleAs 15-25 weight portion, for example approximately 16 weight portions, approximately 17 weight portions or approximately 22 weight portions. According to the use of second aspect present inventionOn the way, the described drug matrices of described topical agent comprises vaseline, and in medicinal material, cinnabar is in 200 weight portions, and vaseline amount is200-800 weight portion, for example 300-700 weight portion, for example 400-600 weight portion, for example 425-550 weight portion, for example approximately 420Weight portion, approximately 480 weight portions or approximately 540 weight portions.
According to the purposes of second aspect present invention, described topical agent comprises:
| Cinnabar | 200 weight portions, |
| Calamine | 20-160 weight portion, |
| Borneol | 25-125 weight portion, |
| Frankincense | 10-80 weight portion, |
| Myrrh | 10-75 weight portion, |
| Rosin | 50-160 weight portion, |
| Castor oil | 20-90 weight portion, |
| Gypsum (forging) | 10-80 weight portion, |
| Camphor | 20-120 weight portion, 7 --> |
| Calculus bovis factitius | 0.5-10 weight portion, |
| Pearl | 0.5-10 weight portion, |
| Drug matrices | 200-850 weight portion. |
According to the purposes of second aspect present invention, described topical agent comprises:
| Cinnabar | 200 weight portions, |
| Calamine | 30-120 weight portion, |
| Borneol | 50-100 weight portion, |
| Frankincense | 15-60 weight portion, |
| Myrrh | 20-50 weight portion, |
| Rosin | 70-140 weight portion, |
| Castor oil | 30-75 weight portion, |
| Gypsum (forging) | 15-50 weight portion, |
| Camphor | 30-100 weight portion, |
| Calculus bovis factitius | 1-5 weight portion, |
| Pearl | 1-5 weight portion, |
| Drug matrices | 300-750 weight portion. |
According to the purposes of second aspect present invention, described topical agent comprises:
| Cinnabar | 200 weight portions, |
| Calamine | 40-100 weight portion, |
| Borneol | 60-80 weight portion, |
| Frankincense | 20-50 weight portion, |
| Myrrh | 25-40 weight portion, |
| Rosin | 80-125 weight portion, |
| Castor oil | 35-60 weight portion, |
| Gypsum (forging) | 25-40 weight portion, |
| Camphor | 40-90 weight portion, |
| Calculus bovis factitius | 1.25-4 weight portion, |
| Pearl | 1.5-4 weight portion, |
| Drug matrices | 400-650 weight portion. |
According to the purposes of second aspect present invention, described topical agent comprises:
| Cinnabar | 200 weight portions, |
| Calamine | 50-80 weight portion, |
| Borneol | 65-75 weight portion, |
| Frankincense | 20-35 weight portion, |
| Myrrh | 25-35 weight portion, 8 --> |
| Rosin | 85-110 weight portion, |
| Castor oil | 40-45 weight portion, |
| Gypsum (forging) | 25-35 weight portion, |
| Camphor | 50-75 weight portion, |
| Calculus bovis factitius | 1.5-3.5 weight portion, |
| Pearl | 2-3 weight portion, |
| Drug matrices | 450-600 weight portion. |
According to the purposes of second aspect present invention, described topical agent comprises:
| Cinnabar | 180 weight portions, |
| Calamine | 70 weight portions, |
| Borneol | 60 weight portions, |
| Frankincense | 30 weight portions, |
| Myrrh | 25 weight portions, |
| Rosin | 100 weight portions, |
| Castor oil | 40 weight portions, |
| Gypsum (forging) | 28 weight portions, |
| Camphor | 60 weight portions, |
| Calculus bovis factitius | 3 weight portions, |
| Pearl | 2.4 weight portions, |
| Lanolin | 20 weight portions, |
| Vaseline | 490 weight portions. |
According to the purposes of second aspect present invention, described topical agent comprises:
| Cinnabar | 190 weight portions, |
| Calamine | 60 weight portions, |
| Borneol | 70 weight portions, |
| Frankincense | 20 weight portions, |
| Myrrh | 30 weight portions, |
| Rosin | 80 weight portions, |
| Castor oil | 40 weight portions, |
| Gypsum (forging) | 25 weight portions, |
| Camphor | 70 weight portions, |
| Calculus bovis factitius | 2.0 weight portions, |
| Pearl | 2.4 weight portions, |
| Lanolin | 15 weight portions, |
| Vaseline | 460 weight portions. |
According to the purposes of second aspect present invention, described topical agent comprises:
| Cinnabar | 200 weight portions, |
| Calamine | 50 weight portions, |
| Borneol | 70 weight portions, |
| Frankincense | 25 weight portions, |
| Myrrh | 30 weight portions, |
| Rosin | 90 weight portions, |
| Castor oil | 40 weight portions, |
| Gypsum (forging) | 30 weight portions, |
| Camphor | 50 weight portions, |
| Calculus bovis factitius | 1.5 weight portions, |
| Pearl | 2.0 weight portions, |
| Lanolin | 25 weight portions, |
| Vaseline | 412 weight portions. |
According to the purposes of second aspect present invention, in described topical agent, each medicinal material is to join through the method for physical treatmentIn described composition.
According to the purposes of second aspect present invention, in described topical agent, each medicinal material is to add through the method for physical crushing processingEnter in described composition. In one embodiment, described physical crushing can be to be selected from following mode: water flies, machineTool is pulverized, is ground and combination.
According to the purposes of second aspect present invention, described topical agent is to be to be selected from following medicine type: plaster, ointmentAgent, emplastrum, cream, paste, lotion, paint, patch, gel, liniment, spray, emplastrum.
According to the purposes of second aspect present invention, in the every 1000g of described topical agent, comprising crude drug total amount is 100-900g,For example 200-800g, for example 300-700g, for example 400-700g, for example 500-700g, for example about 500g, for example 600g, for exampleAbout 700g.
According to the purposes of second aspect present invention, wherein said product is the medicament of ointment.
According to the purposes of second aspect present invention, wherein said topical agent is the medicament of plaster. An embodimentIn, described plaster be by cinnabar, calamine, borneol, frankincense, myrrh, rosin, castor oil, gypsum (forging), camphor, calculus bovis factitius,The material that the medicinal material combination of pearl and drug matrices are made spreads onto to be made in framed back material, and it can stick for skinExternal preparation.
Third aspect present invention provides the method for preparing topical agent described in first aspect present invention any one, and it comprisesFollowing steps:
A, cinnabar water is flown into impalpable powder;
B, pearl, frankincense, myrrh are ground into fine powder;
C, gypsum (forging) is ground into fine powder, crosses 150 mesh sieves;
D, by camphor, calculus bovis factitius, borneol and calamine facing-up, cross 160 mesh sieves;
E, separately get castor oil and endure to dripping into pearl, slightly cold, add pearl, frankincense, myrrh and particulate rosin, stir and make completelyMolten; Add again drug matrices (such as but not limited to lanolin and vaseline), make to melt completely, filter through 120 mesh sieves;
F, add gypsum fine powder, stir evenly, be chilled to below 40 DEG C;
G, camphorate, calculus bovis factitius, borneol, grind well;
H, add cinnabar fine powder, mix, to obtain final product.
According to the method for third aspect present invention, it also further comprises makes described topical agent to be selected from following medicineThe step of agent form: plaster, ointment, emplastrum, cream, paste, lotion, paint, patch, gel, liniment, sprayingAgent, emplastrum.
According to the method for third aspect present invention, it also further comprises the step of described topical agent being made to plasterSuddenly.
According to the method for third aspect present invention, it also further comprises described topical agent is spread onto in framed back materialMake the step of plaster.
Arbitrary technical characterictic that arbitrary embodiment of either side of the present invention or this either side has is applicable equallyArbitrary embodiment of other arbitrary embodiment or other either side, as long as they can be not conflicting, certainly mutuallyBetween where applicable, necessary words can be done suitably to modify to individual features. Do into one with feature to various aspects of the present invention belowThe description of step.
All documents that the present invention quotes from, their full content is incorporated to herein by reference, and if these literary compositionsOffer expressed implication and the present invention when inconsistent, be as the criterion with statement of the present invention. In addition, the present invention use various terms andPhrase has the general sense of well known to a person skilled in the art, nonetheless, the present invention still wish at this these terms andPhrase is described in more detail and explains, the term of mentioning and phrase, if any inconsistent with known implication, are shown with the present inventionThe implication of stating is as the criterion.
In the present invention, can use the topical agent of the present invention (also can be described as composition) of effective dose to be applied to and have needsTested individuality. As described herein, term " effective dose " refers in experimenter, to realize and prevents and/or treats institute of the present inventionState the object dosage of situation, obstacle, illness or disease. Those skilled in the art, can be easily true according to the context of the inventionDetermine the using dosage of topical agent of the present invention. Especially, according to the present invention, term " effective dose " can be understood as external application of the present inventionMedicament be applicable to reasonable effect/risk ratio of any therapeutic treatment and/or prevention treat and/or prevent described situation, obstacle,The q.s of illness or disease. But the total consumption per day that it should be understood that topical agent of the present invention can be existed by those skilled in the artWithin the scope of medical judgment, make decision reliably. For any concrete experimenter, the concrete horizontal fibrous root of prevention effective doseDetermine according to many factors, described factor comprises experimenter's age, body weight, general health situation, sex and diet; AdoptConcrete topical agent; Other therapeutic active substance that is used in combination with topical agent of the present invention or uses simultaneously; And medical fieldKnown similar factor. For the present invention, general daily dose scope is torn open and is counted as medicinal material meter, can be 0.1 ~ 100g/kg bodyHeavy, for example 0.2 ~ 50g/kg body weight, for example 0.2 ~ 25g/kg body weight, for example 0.5 ~ 50g/kg body weight, for example 0.5 ~ 25g/kg bodyHeavy, for example 1 ~ 20g/kg body weight, for example 2 ~ 10g/kg body weight.
The mode that generally speaking product provided by the invention can be smeared by external application is used, with regard to use amount, conventionallyBe to be accustomed to consumption with people to use, for example, for the related illness of the present invention, what use in the treatment of disease sites partial smearing is appropriateAlso can, for example every square centimeter of skin can use 0.1g ~ 1g, for example 0.1g ~ 0.5g, for example 0.1g ~ 0.4g, for example 0.1g ~0.3g, for example 0.2g ~ 0.5g, for example 0.3g ~ 0.5g.
In the present invention, while mentioning " raw medicinal herbs " or " crude drug ", it comprises cinnabar, calamine, frankincense, myrrh, rosin, castorSesame oil, gypsum (forging), pearl, and (if present, can be understood as raw medicinal herbs or crude drug) borneol, camphor, artificialCow-bezoar.
Topical agent provided by the invention can be used for the treatment of and/or prevent disease of skin, described disease of skin for example butBe not limited to the illnesss such as whelk, dark sore, acne, pimples, acne, acne.
The inventor has found to have the Chinese prescription of clearing heat and detoxicating myogenic, activating blood circulation and reducing swelling by creative work, in thisMedicine prescription is evident in efficacy to the treatment of disease of skin of the present invention, have no side effect.
The present invention compared with the prior art, has the following advantages and clinical effectiveness: the present invention selects pure Chinese medicine material, is easy toIndustrialization is produced. In addition, topical agent of the present invention has erosion prevention and muscle growing, the effect such as clearing heat and detoxicating, makes through clinical practice for many yearsBy proof, be used for the treatment of the skin sore class illnesss such as whelk, dark sore, acne, total effective rate reaches more than 95%, and finds noOther toxic and side effect.
Detailed description of the invention
Further illustrate the present invention below by specific embodiment/experimental example, still, should be understood to, these enforcementsExample and experimental example are only used for the use specifically describing more in detail, and should not be construed as for limiting in any form thisBright.
The present invention carries out generality and/or concrete description to the material and the test method that use in test. ThoughBe so well known in the art for realizing many materials and the method for operating that the object of the invention uses, but the present invention is still at thisDo to describe in detail as far as possible. It will be apparent to those skilled in the art that hereinafter, if not specified, material therefor of the present invention andMethod of operating is well known in the art.
A, Preparation Example part
Embodiment 1,2,3: prepare topical agent of the present invention
The formula ratio following (weight portion, with 5000 grams of preparations in batches) of the embodiment of the present invention 1,2,3 topical agents:
| Composition | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Cinnabar | 180 | 190 | 200 |
| Calamine | 70 | 60 | 50 |
| Borneol | 60 | 70 | 70 |
| Frankincense | 30 | 20 | 25 |
| Myrrh | 25 | 30 | 30 |
| Rosin | 100 | 80 | 90 |
| Castor oil | 40 | 40 | 40 |
| Gypsum (forging) | 28 | 25 | 30 |
| Camphor | 60 | 70 | 50 |
| Calculus bovis factitius | 3 | 2.0 | 1.5 |
| Pearl | 2.4 | 2.4 | 2.0 |
| Lanolin | 15 | 20 | 25 |
| Vaseline | 490 | 460 | 412 |
The formula of above-described embodiment is prepared into ointment as follows:
A, cinnabar water is flown into impalpable powder;
B, pearl, frankincense, myrrh are ground into fine powder;
C, gypsum (forging) is ground into fine powder, crosses 150 mesh sieves;
D, by camphor, calculus bovis factitius, borneol and calamine facing-up, cross 160 mesh sieves;
E, separately get castor oil and endure to dripping into pearl, slightly cold, add pearl, frankincense, myrrh and particulate rosin, stir and make completelyMolten; Add again lanolin and appropriate vaseline, make to melt completely, filter through 120 mesh sieves;
F, add gypsum fine powder, stir evenly, be chilled to below 40 DEG C;
G, camphorate, calculus bovis factitius, borneol, grind well;
H, add cinnabar fine powder, mix and make. Semi-finished product are through the red ointment of filling one-tenth after the assay was approved. Lucifuge is airtightPutting shady and cool dry place preserves.
Can further red step H gained ointment compositions be spread onto in framed back material, make and can stick for skinExternally applied ointment.
Embodiment 4,5,6,7: prepare topical agent of the present invention
The formula ratio following (weight portion, with 5000 grams of preparations in batches) of the embodiment of the present invention 4,5,6,7 topical agents:
| Composition | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 |
| Cinnabar | 200 | 200 | 200 | 200 |
| Calamine | 20 | 160 | 120 | 30 |
| Borneol | 125 | 25 | 50 | 100 |
| Frankincense | 10 | 80 | 60 | 15 |
| Myrrh | 75 | 10 | 20 | 50 |
| Rosin | 50 | 160 | 140 | 70 |
| Castor oil | 90 | 20 | 30 | 75 |
| Gypsum (forging) | 10 | 80 | 50 | 15 |
| Camphor | 120 | 20 | 30 | 100 |
| Calculus bovis factitius | 0.5 | 10 | 5 | 1 |
| Pearl | 10 | 0.5 | 1 | 5 |
| Yellow wax | 30 | 2 | 40 | 7.5 |
| Vaseline | 500 | 200 | 300 | 700 |
The method of reference example 1 is prepared above embodiment 4,5,6,7, obtains ointment compositions.
Embodiment 8-11: preparation the present inventionTopical agent
The formula ratio following (weight portion, with 5000 grams of preparations in batches) of embodiment of the present invention 8-11 topical agent:
| Composition | Embodiment 8 | Embodiment 9 | Embodiment 10 | Embodiment 11 |
| Cinnabar | 200 | 200 | 200 | 200 |
| Calamine | 40 | 100 | 55 | 70 |
| Borneol | 80 | 60 | 60 | 75 |
| Frankincense | 20 | 50 | 25 | 35 |
| Myrrh | 40 | 25 | 25 | 40 |
| Rosin | 80 | 125 | 80 | 100 |
| Castor oil | 60 | 35 | 40 | 45 |
| Gypsum (forging) | 25 | 40 | 25 | 30 13 --> |
| Camphor | 90 | 40 | 50 | 75 |
| Calculus bovis factitius | 1.25 | 4 | 1.5 | 3.5 |
| Pearl | 4 | 1.5 | 2 | 2.5 |
| Stearic | 5 | 40 | 5 | 40 |
| Lanolin | 30 | 10 | ||
| Vaseline | 400 | 600 | 600 | 400 |
The method of reference example 1 is prepared above embodiment 8-11, obtains ointment compositions.
B: test example part
For proving the result for the treatment of of present composition medicine to skin sore class illnesss such as whelk, dark sore, acnes, the present inventionThrough the checking of following in vitro test, animal model and three levels such as clinical.
Test example 1: extracorporeal bacteria inhibitor test (using embodiment 1 reagent to test):
Adopt plating method that various bacterial classifications are inoculated on agar plate, be placed in 37 DEG C of incubators and cultivated through 24 hoursAfter, measure its inhibition zone diameter. Get the mean of three antibacterial rings and do t inspection processing (in table, * indicates significant difference), and willPlaster concentration with Pseudomonas aeruginosa inhibition zone diameter is made to Linear correlative analysis.
The bacteriostasis of table 1: embodiment 1 reagent variable concentrations plaster in vitro culture bacterium
Bacteriostatic test shows: no matter the present invention's combination has stronger pressing down to Gram-negative bacteria or gram-positive bacteriaMake use, have broad-spectrum antiseptic effect, its inhibitory effect strengthens with Drug level, has obvious dose-effect relationship.
Inventor, in other parallel test, uses respectively each composition of embodiment 2-11 to carry out above-mentioned test, knotThe inhibition zone diameter that fruit is presented at 7 kinds of bacterial classifications in his-and-hers watches 1 under 5%-80% drug concentration shows with embodiment 1 sample basic identicalResult, for example 10%, under 40% two kind of concentration, inhibition zone diameter and the enforcement of each composition of embodiment 2-11 to 7 kinds of bacterial classificationsExample 1 result differs and is less than 10%.
Test example 2, cavy Ulcer Models (using embodiment 2 reagents to test)
Tested district is cavy dorsal skin. Before test, 2d loses hair or feathers with 8% sodium sulfide solution. When test by prostrate cavy solidFix on frame, intramuscular injection ketalar 50mg/kg, after 3min, animal enters generalized anesthetic state. First at every guinea pig back hand3 diameter 1.30cm of art excision, at a distance of 3cm, reach the damaged fresh surface of a wound of circle of full thick skin on manadesma surface deeply. Afterwards by drawing lotsBe coated with respectively plaster, pitch (each 1.5g) and lid dry gauze, and wrapping is fixing. Within the 10th day and 35 days after surgery, get tissue and send disease inspection.
Table 2: the histological examination result of postoperative different number of days
Test shows: the present composition can provide a good microenvironment for the surface of a wound, accelerates surface of a wound growth and healing,And the elasticity of the surface of a wound after healing, wear resistance and toughness all have in control group, are mainly manifested in epithelialization complete, without microulcerationWith pathological changes such as pectination epithelium pin. Its subcutaneous granulation tissue is abundant, and blood fortune is sufficient, without inflammatory cell infiltration.
Test example 3, clinical verification (using below embodiment 3 reagents to test):
Reagent of the present invention is through 600 routine system observation on Clinical Application, and selects medical history, the state of an illness, age, sex and originally treatmentPatient's 600 examples that method is suitable are observed as a control group. The cases such as the whelk of diagnosis establishment, dark sore, acne are selected by dept. of dermatology.The wherein male sex's 420 examples, women's 180 examples, age distribution is in 15-50 year, and course of disease 10-30 days are not etc.
Whelk, dark sore, three kinds of common diseases of acne are carried out to clinical control treatment and observe, when case grouping, try one's best allEven, wherein whelk, dark sore, each 200 examples of three kinds of illnesss of acne in test group, whelk, dark sore, three kinds of diseases of acne in control groupEach 200 examples of disease.
The cream drug that test group reagent is used embodiment 3 to make; Control group reagent is used commercially available pearl acne cream((2006) defend the accurate word 26-XK-0223 of adornment), a kind of ointment that is applicable to dark sore, acne, whelk etc., have dispel dark sore,Soft cutin, except the acne functions such as mite of dispelling. Test group reagent and control group reagent during for whelk, dark sore, three kinds of illnesss of acneUse amount smear in right amount in affected part according to people's usual experience, one day 3 times. Use 35 days continuously.
The clinical treatment comparison of A, two groups of whelks
Table 3: treatment group and control group are to the whelk treatment accumulative total cure rate of 1,7,14,30 day
| Number of days | 1 day | 7 days | 14 days | 30 days |
| Test group 200 examples | 0 | 20% | 80% | 92% |
| Control group 200 examples | 0 | 5% | 45% | 85% |
From table 3, treatment group at the accumulative total cure rate of 7,14,30 days apparently higher than control group.
The clinical treatment comparison of B, two groups of dark sores
Table 4: treatment group and control group are to the dark sore treatment accumulative total cure rate of 1,7,14,30 day
| Number of days | 1 day | 7 days | 14 days | 30 days |
| Test group 200 examples | 0 | 30% | 85% | 94% |
| Control group 200 examples | 0 | 10% | 41% | 74% |
From table 4, treatment group at the accumulative total cure rate of 7,14,30 days apparently higher than control group.
The clinical treatment comparison of C, two groups of acnes
Table 5: treatment group and control group are to the acne treatment accumulative total cure rate of 1,7,14,30 days
| Number of days | 1 day | 7 days | 14 days | 30 days |
| Test group 200 examples | 0 | 24.5% | 68% | 95% |
| Control group 200 examples | 0 | 12% | 40.5% | 78% |
From table 5, treatment group at the accumulative total cure rate of 7,14,30 days apparently higher than control group.
Test example 4, model case (using embodiment 2 compositions to test):
Case 1
Patient Wang, female, 19 years old. Face seat sore does not heal for 4 years, and while examining, meeting portion, especially forehead and dilator naris skin are generalRed, hair gives two coarse, a purulence papule that have chestnut grain sample and grain of rice sample to differ in size, or accompanies the hair follicle of most blackheads, expansionIn mouthful, can extrude white greasy sample powder juice, have phlegm gargalesthesia, after solar radiation, color of the leather is general very red, sufferings aggravation, neck and thoracic dorsalPortion also distributes, and disease belongs to the papule pustular type sore of fullying recover from an illness. With the embodiment of the present invention 2 compositions smear outward, skin damages obviously and reduces after two weeks,Look red turns light, after February skin damage substantially disappear, skin recovers normal.
Case 2
Patient Zhang, man, 42 years old, people from Qiaosi, Hangzhou. Outside patient's tuberosity of tibia furuncle burst after more do not reach three months itFor a long time, be the sore ulcer of lower limb through certain hospital diagnosis, treatment is remaining invalid February.
Check: patient grows medium, eutrophy, cardiopulmonary are normal, lassitude in loin and legs, local pain is itched. Shin bone outer rim ZusanliPlace has one approximately 5 × 5 centimetre of ulcer surface, the small size ulcer that differs in size three places, pigmentation, the calibration of internal orifice neat in edge aroundNormal skin is slightly high, and sore face is slight spill, and surface has sepia slough topped, oozes out with a small amount of purulent secretion. ExamineBreak as the sore ulcer of lower limb.
Control suitable temperature compensation qi and blood, righting holder poison, goes corruption loose tired, and myogenic is put on flesh. Side is for oral administration with general tonic pill, sooner or later respectively takes oneBall, externally applied ointment sticks. Change dressings after five times with embodiment 2 plaster, ulcer surface slough gradually moves back, the appearance that newly granulates, purulenceLook flavescence white hair is thick, and rear continuation is closed up for 12 times with plaster external application and healed, and follows up a case by regular visits to for several times, without recurrence.
Claims (12)
1. being combined in for the preparation of the purposes treating and/or preventing in the topical agent of disease of skin of following 11 kinds of Chinese medicines:Cinnabar, calamine, borneol, frankincense, myrrh, rosin, castor oil, calcined gypsum, camphor, calculus bovis factitius and pearl;
In described topical agent medicinal material, cinnabar is taking 200 weight portions: calamine amount is as 20-160 weight portion, borneol amount are as 25-125Weight portion, frankincense amount be 10-80 weight portion, do not have dose is that 10-75 weight portion, rosin amount are 50-160 weight portion, castor-oil plant oil massFor 20-90 weight portion, calcined gypsum amount are that 10-80 weight portion, camphor amount are that 20-120 weight portion, calculus bovis factitius amount are that 0.5-10 is heavyAmount part, pearl amount are 0.5-10 weight portion, also comprise drug matrices in this topical agent, and its amount is 200-850 weight portion;
Described drug matrices is to be selected from following one or more: lanolin, vaseline, yellow wax, tristearin, natural rubber, liquidParaffin.
2. according to the purposes of claim 1, wherein said disease of skin is selected from: whelk, dark sore, acne.
3. according to the purposes of claim 1, the described drug matrices of described topical agent comprises lanolin, in medicinal material cinnabar with200 weight portion meters, lanolin amount is 5-50 weight portion.
4. according to the purposes of claim 1, the described drug matrices of described topical agent comprises vaseline, in medicinal material cinnabar with200 weight portion meters, vaseline amount is 200-800 weight portion.
5. according to the purposes of claim 1, in described topical agent, each medicinal material is to join described group through the method for physical treatmentIn compound.
6. according to the purposes of claim 1, in the every 1000g of described topical agent, comprising crude drug total amount is 100-900g.
7. according to the purposes of claim 1, in described topical agent, consist of: cinnabar 200 weight portions, calamine 30-120 weightPart, borneol 50-100 weight portion, frankincense 15-60 weight portion, myrrh 20-50 weight portion, rosin 70-140 weight portion, castor oil30-75 weight portion, calcined gypsum 15-50 weight portion, camphor 30-100 weight portion, calculus bovis factitius 1-5 weight portion, pearl 1-5 weightPart, drug matrices 300-750 weight portion.
8. according to the purposes of claim 1, in described topical agent, consist of: cinnabar 200 weight portions, calamine 40-100 weightPart, borneol 60-80 weight portion, frankincense 20-50 weight portion, myrrh 25-40 weight portion, rosin 80-125 weight portion, castor oil 35-60 weight portions, calcined gypsum 25-40 weight portion, camphor 40-90 weight portion, calculus bovis factitius 1.25-4 weight portion, pearl 1.5-4 weightPart, drug matrices 400-650 weight portion.
9. according to the purposes of claim 1, in described topical agent, consist of: cinnabar 200 weight portions, calamine 50-80 weightPart, borneol 65-75 weight portion, frankincense 20-35 weight portion, myrrh 25-35 weight portion, rosin 85-110 weight portion, castor oil 40-45 weight portions, calcined gypsum 25-35 weight portion, camphor 50-75 weight portion, calculus bovis factitius 1.5-3.5 weight portion, pearl 2-3 weightPart, drug matrices 450-600 weight portion.
10. according to the purposes of claim 1, in described topical agent, consist of: cinnabar 180 weight portions, calamine 70 weight portions,Borneol 60 weight portions, frankincense 30 weight portions, myrrh 25 weight portions, rosin 100 weight portions, castor oil 40 weight portions, calcined gypsum 28Weight portion, camphor 60 weight portions, calculus bovis factitius 3 weight portions, pearl 2.4 weight portions, lanolin 20 weight portions, vaseline 490 weightsAmount part.
11. according to the purposes of claim 1, in described topical agent, consists of: cinnabar 190 weight portions, calamine 60 weight portions,Borneol 70 weight portions, frankincense 20 weight portions, myrrh 30 weight portions, rosin 80 weight portions, castor oil 40 weight portions, calcined gypsum 25 weightsAmount part, camphor 70 weight portions, calculus bovis factitius 2.0 weight portions, pearl 2.4 weight portions, lanolin 15 weight portions, vaseline 460 weightsAmount part.
12. according to the purposes of claim 1, in described topical agent, consists of: cinnabar 200 weight portions, calamine 50 weight portions,Borneol 70 weight portions, frankincense 25 weight portions, myrrh 30 weight portions, rosin 90 weight portions, castor oil 40 weight portions, calcined gypsum 30 weightsAmount part, camphor 50 weight portions, calculus bovis factitius 1.5 weight portions, pearl 2.0 weight portions, lanolin 25 weight portions, vaseline 412 weightsAmount part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210234682.3A CN102697835B (en) | 2012-07-09 | 2012-07-09 | The topical agent for the treatment of disease of skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210234682.3A CN102697835B (en) | 2012-07-09 | 2012-07-09 | The topical agent for the treatment of disease of skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102697835A CN102697835A (en) | 2012-10-03 |
| CN102697835B true CN102697835B (en) | 2016-05-11 |
Family
ID=46891082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210234682.3A Active CN102697835B (en) | 2012-07-09 | 2012-07-09 | The topical agent for the treatment of disease of skin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102697835B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739728A (en) * | 2015-04-15 | 2015-07-01 | 杨德育 | Quick pox-removing liquor and preparation method thereof |
| CN105616681A (en) * | 2016-01-04 | 2016-06-01 | 马林 | Traditional Chinese medicinal composition for treating acne |
| CN106806593A (en) * | 2017-02-14 | 2017-06-09 | 镇平县尤普实业有限公司 | A kind of Chinese medicine composition for skin nursing |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169286A (en) * | 1996-06-21 | 1998-01-07 | 李笑雷 | Ointment of quickly removing acne without blackspot |
| CN1543930A (en) * | 2003-11-25 | 2004-11-10 | 李忠文 | Method for making plaster adhesive bandage |
-
2012
- 2012-07-09 CN CN201210234682.3A patent/CN102697835B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169286A (en) * | 1996-06-21 | 1998-01-07 | 李笑雷 | Ointment of quickly removing acne without blackspot |
| CN1543930A (en) * | 2003-11-25 | 2004-11-10 | 李忠文 | Method for making plaster adhesive bandage |
Non-Patent Citations (2)
| Title |
|---|
| 梅花点舌丸联合姜黄消痤搽剂治疗痤疮93例;杨敏等;《医药导报》;20111231;第30卷(第12期);第1568-1569页 * |
| 痤疮方系列配合外治法治疗寻常痤疮238例临床观察;陈潍等;《河北中医》;20070131;第29卷(第1期);第14-16页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102697835A (en) | 2012-10-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11571452B2 (en) | Method of treating a skin wound with a liquid-state topical pharmaceutical composition | |
| CN104306358B (en) | Antipruritic scar liniment of dispelling | |
| CN100404054C (en) | Decoction Chinese medicine sterilizing antiphlogistic, preparation and use thereof | |
| CN110292602A (en) | Yellow burn oil formula of a kind of compound five and preparation method thereof | |
| CN101837082B (en) | Chinese preparation for treating burn without leaving scar | |
| CN102697835B (en) | The topical agent for the treatment of disease of skin | |
| CN105662996A (en) | Traditional Chinese medicine mask for treating menstruation-associated acne | |
| CN105943666B (en) | Composition for nursing sensitive skin of infant and preparation method thereof | |
| CN102274380B (en) | External applied medicine for treating burn and scalding | |
| CN101439114A (en) | Chinese medicine for treating burn and scald, and preparation method thereof | |
| CN102697855B (en) | Medicinal composition for treating skin diseases | |
| CN103432049B (en) | Composition with deodorization function | |
| CN101062085B (en) | Condyloma acuminata treating medicine | |
| CN108785384A (en) | A kind of Chinese medicine composition containing zinc and its preparation for treating acne | |
| CN105031254B (en) | A kind of paste and preparation method thereof for treating dermatitis | |
| CN101690760B (en) | Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof | |
| CN102379963A (en) | Skin wound treating ointment and preparation method thereof | |
| CN103191163A (en) | Skin wound repairing pharmaceutical composition | |
| CN102178795B (en) | External medicine for treating burns and scalds and preparation method of medicine | |
| CN104000919A (en) | Traditional Chinese medicine composition | |
| CN107714834A (en) | A kind of composition of camellia oil preparation for external use, preparation method and applications | |
| CN101904915B (en) | Chinese medicinal composition for promoting fast recovery of burn | |
| CN106728069A (en) | It is a kind of to treat the putrefaction-removing granulation-promoting paste for scalding burn | |
| CN105726789A (en) | Nursing drug preparation for treating bedsore and application thereof | |
| CN105055622B (en) | A kind of Chinese medicine film-forming gel agent treating either shallow bed sore at ulcerative stage |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |