CN101690760B - Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof - Google Patents
Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof Download PDFInfo
- Publication number
- CN101690760B CN101690760B CN2009101126256A CN200910112625A CN101690760B CN 101690760 B CN101690760 B CN 101690760B CN 2009101126256 A CN2009101126256 A CN 2009101126256A CN 200910112625 A CN200910112625 A CN 200910112625A CN 101690760 B CN101690760 B CN 101690760B
- Authority
- CN
- China
- Prior art keywords
- ointment
- dry flower
- oleum camelliae
- days
- rose root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims description 14
- 208000014674 injury Diseases 0.000 title abstract description 4
- 230000008733 trauma Effects 0.000 title abstract description 3
- 239000011505 plaster Substances 0.000 title abstract 3
- 239000003814 drug Substances 0.000 claims abstract description 41
- 206010053615 Thermal burn Diseases 0.000 claims abstract description 17
- 229940079593 drug Drugs 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 239000002674 ointment Substances 0.000 claims description 55
- 241000628997 Flos Species 0.000 claims description 18
- 238000011282 treatment Methods 0.000 claims description 17
- 208000027418 Wounds and injury Diseases 0.000 claims description 15
- 206010052428 Wound Diseases 0.000 claims description 14
- 238000004321 preservation Methods 0.000 claims description 14
- 231100000075 skin burn Toxicity 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 abstract description 15
- 230000006378 damage Effects 0.000 abstract description 8
- 208000024891 symptom Diseases 0.000 abstract description 6
- 230000008929 regeneration Effects 0.000 abstract description 5
- 238000011069 regeneration method Methods 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 4
- 231100000241 scar Toxicity 0.000 abstract description 4
- 241000218033 Hibiscus Species 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 210000004927 skin cell Anatomy 0.000 abstract description 2
- 235000005206 Hibiscus Nutrition 0.000 abstract 2
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 abstract 2
- 244000042430 Rhodiola rosea Species 0.000 abstract 2
- 235000003713 Rhodiola rosea Nutrition 0.000 abstract 2
- 239000010495 camellia oil Substances 0.000 abstract 2
- 208000032544 Cicatrix Diseases 0.000 abstract 1
- 230000037387 scars Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 210000000582 semen Anatomy 0.000 description 10
- 241000700159 Rattus Species 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 7
- 230000036407 pain Effects 0.000 description 7
- 210000000589 cicatrix Anatomy 0.000 description 6
- 210000002615 epidermis Anatomy 0.000 description 6
- 230000035876 healing Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 210000003414 extremity Anatomy 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 241001122767 Theaceae Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000003141 lower extremity Anatomy 0.000 description 3
- 230000007721 medicinal effect Effects 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 244000048199 Hibiscus mutabilis Species 0.000 description 2
- 235000003973 Hibiscus mutabilis Nutrition 0.000 description 2
- 235000011449 Rosa Nutrition 0.000 description 2
- 235000004789 Rosa xanthina Nutrition 0.000 description 2
- 241000220222 Rosaceae Species 0.000 description 2
- 208000028990 Skin injury Diseases 0.000 description 2
- 206010042566 Superinfection Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000002266 amputation Methods 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- 230000002951 depilatory effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 102000005606 Activins Human genes 0.000 description 1
- 108010059616 Activins Proteins 0.000 description 1
- 241001119624 Aesculus chinensis Species 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 241001596328 Camellia meiocarpa Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 244000271144 Crinum americanum Species 0.000 description 1
- 206010051814 Eschar Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010034016 Paronychia Diseases 0.000 description 1
- 241000029132 Paronychia Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 235000015402 Rosa cymosa Nutrition 0.000 description 1
- 241000237025 Rosa cymosa Species 0.000 description 1
- 241000220221 Rosales Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010061363 Skeletal injury Diseases 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000488 activin Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 231100000333 eschar Toxicity 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000003243 intestinal obstruction Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000008470 skin growth Effects 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- ALNUHUMOGUVHIO-XXJNWDAFSA-M sodium;7-[(1r,2s)-2-hexyl-5-hydroxycyclopentyl]heptanoate Chemical compound [Na+].CCCCCC[C@H]1CCC(O)[C@@H]1CCCCCCC([O-])=O ALNUHUMOGUVHIO-XXJNWDAFSA-M 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a composition with medicinal value, a prepration method and an application thereof, and the composition consists of the following pharmaceutical raw materials of fresh leaves of smallfruit rose root leaves, dried hibiscus flowers and tea oil. The invention further provides a technology for preparing a plaster, which comprises the following steps: firstly using the fresh leaves of the smallfruit rose root leaves and the dried hibiscus flowers to prepare medicinal mud, and then mixing the medicinal mud with the tea oil, thereby preparing the plaster. When a drug prepared by the pharmaceutical composition is used for treating skin trauma or damage symptom, the efficacy is evident, thereby being especially applicable to treating burns, scalds and the like, leading most of patients to be naturally healed within 2-15 days without leaving scars and being the ideal skin cell regeneration and rehabilitation drug for external application.
Description
Technical field
The present invention relates to a kind of preparation method, application for the treatment of the pharmaceutical composition and the ointment thereof of wound.
Background technology
Body surface wound or breakage are the pains of injury common during people live, and particularly scald, burn etc. is common especially.
The grade of burning such as burn, scald is usually adopted following criteria:
Once burnt: damage is limited to the epidermis shallow-layer.Symptom is that illing skin is rubescent, and pain is inviolent.But normal healing, no cicatrix.
Two degree are burnt, and are divided into:
1. shallow two degree are burnt: damage on epidermis and the corium 1/3, symptom is that the affected part redness is got blister, and can have an intense pain and burning sensation.But normal healing, no cicatrix or slight cicatrix.
2. dark two degree are burnt: damage and be epidermis and corium deep, symptom is that the affected part is rubescent, plays the big blister of white, because teleneuron is partially damaged, more shallow two degree of pain want light.But normal healing can stay cicatrix.
Third-degree burn: whole skin injurys.The affected part is hide-like black eschar or pale, and the flow liquid phenomenon can be arranged.Because most of teleneuron damages, this type of bright the wounded does not often have the affected part pain.
Four degree are burnt: subcutaneous tissue, muscle even skeletal injury are arranged.Can cause amputation.
Five degree are burnt: most of subcutaneous tissue is burnt, and exposes muscular tissue.Sometimes to burn be fatal to five degree.
Six degree are burnt: nearly all meat fiber disappears, and skeleton is burnt.Six degree are burnt normally fatal.
For the damage of rats after severe scald burn burn class, common treatment means no doubt can obtain certain curative effect now, but its curative effect is still not satisfactory, mainly show as: to the serious burn and scald of integumentary musculature, and the patient of severe infections behind the burn and scald, healing time is long, and curative effect is undesirable, leaves cicatrix etc.
Summary of the invention
The pharmaceutical composition that the purpose of this invention is to provide the preferable treatment wound of a kind of curative effect.
Another object of the present invention provides a kind of preparation method of said composition ointment.
The present invention also provides the application of a kind of this pharmaceutical composition in the medicine of the wound of rotting at preparation treatment skin burn, skin scald or skin.
For realizing first goal of the invention, the invention provides a kind of pharmaceutical composition, this pharmaceutical composition is made by the crude drug of following weight ratio example: plucking time at 3 days with the bright leaf 80%～97% of interior Smallfruit Rose Root, Flos Hibisci Mutabilis dry flower 2%～19%, Oleum Camelliae 1%～10%.
Flos Hibisci Mutabilis is the flower of Malvaceae Hibiscus plant Hibisci Mutabilis in the compositions, and another name is named refuses frostwork.Hibisci Mutabilis formal name used at school: Hibiscus mutabilis, English name Cotton rose.Have heat-clearing and toxic substances removing, cooling blood for hemostasis, the medicinal efficacy of detumescence and apocenosis is applicable to diseases such as furuncle, carbuncle sore, acute mastitis and cough due to lung-heat, lung abscess, the metrorrhagia that available again what heat in blood causes.
The fruitlet Rosa is in Rosaceae (Rosaceae) Rosa (RosaL.) plant in the compositions, formal name used at school Rosa cymosa Tratt, another name: Radix Rosae Cymosae, fishing rod, Radix Rosae Cymosae, spend Aesculus chinensis Bunge, seven sisters etc. in vain.But Smallfruit Rose Root leaf removing toxic substances and promoting subsidence of swelling is used to control carbuncle furuncle infections, burn and scald.
Oleum Camelliae is the fatty oil that the mature seed of plant of theaceae oil tea (Camelliia oleifera Abel) or lobule oil tea (Camellia meiocarpa Hu.ms.) obtains with milling process in the compositions.Cure mainly: eruptive disease stomachache; Constipation; Ascarid stomachache; Ascaris intestinal obstruction; Scabies; Burn.
In order to obtain better medicinal effects, this pharmaceutical composition formula optimization is that the weight proportion of described crude drug is: plucking time 3 days with the bright leaf 95%～97% of interior Smallfruit Rose Root, water content at the Flos Hibisci Mutabilis dry flower 2%～4% below 10%, Oleum Camelliae 1%～0.3%.
In order to obtain better medicinal effects, this pharmaceutical composition formula optimization is, described Flos Hibisci Mutabilis dry flower be plucking time at 6 months with interior dry flower.
In order to obtain better medicinal effects, to use for the ease of people simultaneously, this medicine composition dosage form is a unguentum.
For realizing second goal of the invention, the invention provides a kind of preparation method of using the aforementioned proportion medicine as the ointment of raw material, may further comprise the steps:
A. prepare raw material: prepare crude drug by following proportioning: plucking time at 3 days with the bright leaf 80%～97% of interior Smallfruit Rose Root, Flos Hibisci Mutabilis dry flower 2%～19%, Oleum Camelliae 1%～10%;
B. make medicine mud: bright leaf of Smallfruit Rose Root leaf and the Flos Hibisci Mutabilis dry flower prepared among the step a are made medicine mud;
C. call in Oleum Camelliae: in the medicine mud that step b obtains, add Oleum Camelliae and mixing, make ointment.
Optimization method as above-mentioned ointment preparation method, each proportion of raw materials adopts: plucking time 3 days with the bright leaf 95%～97% of interior Smallfruit Rose Root, water content at the Flos Hibisci Mutabilis dry flower 2%～4% below 10%, Oleum Camelliae 1%～0.3%, the medicine effect that such crude drug ratio is prepared is better.
As the preferred version of technology, the present invention is further comprising the steps of:
D. cold preservation is carried out cold preservation to ointment after promptly making ointment, and to obtain better preservation effect, best refrigerated storage temperature is 3 ℃～-25 ℃, and this condition can be obtained best preservation effect.
For realizing the 3rd goal of the invention, the invention provides the application of a kind of this pharmaceutical composition in the medicine of the wound of rotting at preparation treatment skin burn, skin scald or skin.
This composite medicine preparation method is simple, and is with low cost and have a notable therapeutic effect; The ointment that makes according to crude drug prescription of the present invention and ointment production technology is through clinical verification, and internal energy pain relieving of short time has the cell regeneration effect to skin trauma.Be used for the treatment of skin injurys such as empyrosis, can cure in 1～2 day most of 1 degree fire victim, can cure in 3～5 days most of 2 degree fire victims, to most of 3 above burn and scald of degree or the septic patient of skin height is can cure in 7～15 days, and preventing from scar, be that application compress are restored in a kind of ideal skin cell regeneration.
Trial edition invention ointment in somewhere is scalded the patient to serious burn and is treated, and its result adds up as follows: burn, scald patient 7 people, and wherein 3 spend patient 6 people that burn, and 4 spend patient 1 people that burns; Male 4 people among the patient, women 3 people; Age is not waited from 7 years old by 32 years old.Use ointment of the present invention by 1 to 3 drug of topical application every day, therapeutic outcome is as follows: 10 have 4 people with interior cured person, and cured person has 3 people in 10～15 days, cure rate 100%, and the prognosis preventing from scar does not have apparent side effect.
Description of drawings
Accompanying drawing 1 is the schematic flow sheet of ointment preparation method of the present invention.
The specific embodiment
Embodiment 1
Get the Smallfruit Rose Root leaf 470g that won the same day, pluck 3 months Hibisci Mutabilis dry flower 25g, water content 8% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 5g Oleum Camelliae (Oleum Camelliae is that the Semen Camelliae squeezing get), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed 0 ℃ environment preservation.
Embodiment 2
Pick 2 days Smallfruit Rose Root leaf 485g, pluck 4 months Hibisci Mutabilis dry flower 10g, water content 6% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 5g Oleum Camelliae (Oleum Camelliae get for the squeezing of lobule Semen Camelliae), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed-25 ℃ to 3 ℃ environment preservation.
Embodiment 3
Pick 3 days Smallfruit Rose Root leaf 450g, pluck 6 months Hibisci Mutabilis dry flower 40g, water content 15% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 10g Oleum Camelliae (Oleum Camelliae is that the Semen Camelliae squeezing get), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed-25 ℃ to 3 ℃ environment preservation.
Embodiment 4
Pick 3 days Smallfruit Rose Root leaf 400g, pluck 6 months Hibisci Mutabilis dry flower 95g, water content 20% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 5g Oleum Camelliae (Oleum Camelliae is that the Semen Camelliae squeezing get), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed-25 ℃ to 3 ℃ environment preservation.
Embodiment 5
Pick 3 days Smallfruit Rose Root leaf 485g, pluck 6 months Hibisci Mutabilis dry flower 10g, water content 5% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 5g Oleum Camelliae (Oleum Camelliae get for the squeezing of lobule Semen Camelliae), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed-25 ℃ to 3 ℃ environment preservation.
Embodiment 6
Pick 3 days Smallfruit Rose Root leaf 400g, pluck 6 months Hibisci Mutabilis dry flower 50g, water content 10% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 50g Oleum Camelliae (Oleum Camelliae get for the squeezing of lobule Semen Camelliae), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed-25 ℃ to 3 ℃ environment preservation.
Embodiment 7
Pick 3 days Smallfruit Rose Root leaf 475g, pluck 6 months Hibisci Mutabilis dry flower 20g, water content 5% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 5g Oleum Camelliae (Oleum Camelliae is that the Semen Camelliae squeezing get), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed-25 ℃ to 3 ℃ environment preservation.
Embodiment 8
Pick 3 days Smallfruit Rose Root leaf 485g, pluck 6 months Hibisci Mutabilis dry flower 13.5g, water content 5% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 1.5g Oleum Camelliae (Oleum Camelliae is that the Semen Camelliae squeezing get), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed-25 ℃ to 3 ℃ environment preservation.
Embodiment 9
Pick 3 days Smallfruit Rose Root leaf 480g, pluck 6 months Hibisci Mutabilis dry flower 17g, water content 5% in the dry flower, mixes and smashes into the mud shape, and the medicine mud that makes is added 3g Oleum Camelliae (Oleum Camelliae is that the Semen Camelliae squeezing get), is in harmonious proportion evenly, makes ointment.The ointment of the present invention that makes placed-25 ℃ to 3 ℃ environment preservation.
, form the antimicrobial protection film if but this drug main Smallfruit Rose Root leaf endogenetic fungus human activin cell regeneration vigor kills the body inner virus.Thereby play therapeutic effect.Flos Hibisci Mutabilis, Oleum Camelliae have heat-clearing and toxic substances removing, invigorating blood circulation what, fresh-keeping the preserving moisture of medicine are had good result human body, Oleum Camelliae can guarantee the survival of Smallfruit Rose Root leaf endogenetic fungus, can guarantee that fungus can play a role, Oleum Camelliae can promote the growth and breeding of Smallfruit Rose Root leaf endogenetic fungus simultaneously, makes it bring into play therapeutical effect better.
This drug main will show and can efficiently kill virus, toxin expelling, effectively removes the muscular death part, does not stay residue, and removing the protecting film that downright bad muscle surface generates covering automatically, prevents superinfection.This medicine can activate the skin growth factor on the other hand, quickens skin and duplicates, and quickens to promote muscle cell regeneration to duplicate with human body skin.So this formulation product can play good therapeutic effect, treatment time is short, and can form effective protecting film, prevents superinfection.
Embodiment 10
Use embodiment 1,2,3 described ointment respectively with the bright leaf of Smallfruit Rose Root, Oleum Camelliae, Flos Hibisci Mutabilis dry flower are used for the treatment of rat scalds, and divides six groups to carry out, every group is used 20 of rat, specific as follows:
Experiment bark fetching skin not damaged healthy white rat, with rat spinal column both sides metastomium skin with the depilation of depilatory sodium sulfide, the about 3cm * 4cm of area, (account for body surface 10%).Use the warm water cleaning depilatory, return cage to observe about 24 hours, see abnormal phenomenas such as skin zero damage, redness, erythra.To window in the middle of 6cm * 6cm medical proof fabric, area 3cm * 4cm, make the big cotton pad of 3cm * 4cm again, to eat about rusting heat to 140 ℃, the big cotton pad of adhesional wetting takes out and is affixed on immediately on the depilation skin, take off after 30 seconds, making and scalding the position is that dark two degree are scalded, and observes and sees after 24 hours that wound surface has tangible inflammatory reaction to change, as purplish red hyperemia, edema etc.The area and the degree of depth that the rat of each group is scalded are similar, the wound surface area of record rat.After animal model made, each component cage was raised, and gave following medicine: embodiment 1 described ointment, embodiment 2 described ointment, embodiment 3 described ointment, the bright leaf of Smallfruit Rose Root leaf, Flos Hibisci Mutabilis dry flower, Oleum Camelliae respectively.The administration process is directly coating, once a day.Carry out 2 experiments altogether, once for scalding administration in back 10 minutes, once for scalding administration in back 24 hours, 6 groups of different pharmaceutical are all carried out in each experiment, and every group is used 20 rat.
The medicine mud that the bright leaf of the Smallfruit Rose Root leaf that uses in the present embodiment is smash for the Smallfruit Rose Root leaf of plucking 1 day;
The Flos Hibisci Mutabilis dry flower that uses in the present embodiment is that moisture about 8% Flos Hibisci Mutabilis dry flower is smash patent medicine mud with deionized water;
The Oleum Camelliae that uses in the present embodiment gets as the Semen Camelliae squeezing, directly spreads upon the affected part during use.
(1) burn medication in back 10 minutes:
| Embodiment 1 described ointment group | Embodiment 2 described ointment groups | Embodiment 3 described ointment groups | The bright leaf group of Smallfruit Rose Root leaf | Flos Hibisci Mutabilis dry flower group | The Oleum Camelliae group | |
| Cure in 3 days | 18 | 19 | 17 | 0 | 0 | 0 |
| Cured in 3～5 days | 2 | 1 | 3 | 10 | 0 | 0 |
| Cured in 5～10 days | 0 | 0 | 0 | 10 | 9 | 8 |
| Do not cure | 0 | 0 | 0 | 0 | 11 | 12 |
| Total effective rate | 100％ | 100％ | 100％ | 100％ | 45％ | 40％ |
(2) burn medication in back 24 hours:
| Embodiment 1 described ointment group | Embodiment 2 described ointment groups | Embodiment 3 described ointment groups | The bright leaf group of Smallfruit Rose Root leaf | Flos Hibisci Mutabilis dry flower group | The Oleum Camelliae group |
| Cure in 3 days | 0 | 0 | 0 | 0 | 0 | 0 |
| Cured in 3～5 days | 1 | 2 | 0 | 0 | 0 | 0 |
| Cured in 5～10 days | 16 | 17 | 17 | 1 | 0 | 0 |
| Cured in 10～15 days | 3 | 1 | 3 | 19 | 2 | 2 |
| Do not cure | 0 | 0 | 0 | 0 | 18 | 18 |
| Total effective rate | 100％ | 100％ | 100％ | 100％ | 10％ | 10％ |
Embodiment 11
Patient Liu, the woman, 7 years old, both feet were by the boiled water rats after severe scald burn, a few hours are sent treatment to hospital after hindering, the attending doctor was once advising amputation, adopted external application of ointment treatment of the present invention in back 11 days in wound, used the back wound to feel comfortable, apply 3 times every day later on, the wound symptom is clearly better after a few days, uses after 15 days, scalds wound and returns to one's perfect health.
Embodiment 12
Patient Zeng, the woman, 39 years old, boiled water was scalded, and left lower extremity 2 degree are burnt, and area reaches 20%, and epidermis festers, frowziness.Use external application of ointment treatment of the present invention; cooperate the penicillin intravenous drip to protect from infection; treat and do not have obvious phenomenon in first day; found suppurating sore place desiccation in second day; and white antimicrobial protection film appears; begin to occur the thigh heel after the 3rd day and grow 1 cun fresh epidermis in the left and right sides, ulcer surface disappears, and begins healing.Change to restore external application of ointment every day,, scald and suffer from limb and restore, do not find ill symptoms after stopping using ointment through a wheat harvesting period through treatment in seven days.After the patient suffers from the limb recovery from illness, preventing from scar, epidermis is the same with normal skin, and the non-pigment calmness does not influence and suffers from the limb function, observes having no side effect at present.
Embodiment 13
The patient relies certain, the man, and 22 years old, boiled water was scalded, and left lower extremity 1 degree is burnt, area reaches 6.5%, and the surface is red and swollen, and scorching hot pain is used external application of ointment treatment of the present invention to scald skin of lower extremity after 3 days and begun to close up, cure after 5～6 days, no cicatrix is residual, does not influence to suffer from the limb function, observes having no side effect at present.
Embodiment 14
Patient Liao, the woman, 34 years old, suffered from paronychia 3 years, conventional treatments is invalid, repeatedly recurrence.Use ointment of the present invention to smear once every day, smeared continuously 3 days, week back recovery from illness.
Claims (7)
1. a pharmaceutical composition for the treatment of wound is characterized in that, is made by the crude drug of following weight ratio example: plucking time at 3 days with the bright leaf 80%～97% of interior Smallfruit Rose Root, Flos Hibisci Mutabilis dry flower 2%～19%, Oleum Camelliae 1%～10%.
2. compositions as claimed in claim 1 is characterized in that: described Flos Hibisci Mutabilis dry flower be plucking time half a year with interior dry flower.
3. compositions as claimed in claim 1 is characterized in that: the dosage form of this pharmaceutical composition is a unguentum.
4. the application of compositions as claimed in claim 1 in the medicine of preparation treatment skin burn, skin scald or the rotten wound of skin.
5. an ointment preparation method is characterized in that, may further comprise the steps:
A. prepare raw material: prepare crude drug by following proportioning: plucking time at 3 days with the bright leaf 80%～97% of interior Smallfruit Rose Root, Flos Hibisci Mutabilis dry flower 2%～19%, Oleum Camelliae 1%～10%;
B. make medicine mud: bright leaf of Smallfruit Rose Root leaf and the Flos Hibisci Mutabilis dry flower prepared among the step a are made medicine mud;
C. call in Oleum Camelliae: in the medicine mud that step b obtains, add Oleum Camelliae and mixing, make ointment.
6. ointment preparation method as claimed in claim 5 is characterized in that, it is afterwards further comprising the steps of to make ointment: d. cold preservation: the ointment that step c is obtained carries out stored refrigerated.
7. ointment preparation method as claimed in claim 6 is characterized in that: described stored refrigerated temperature is: 3 ℃～-25 ℃.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101126256A CN101690760B (en) | 2009-10-12 | 2009-10-12 | Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof |
| PCT/CN2009/074713 WO2011044736A1 (en) | 2009-10-12 | 2009-10-30 | Pharmaceutical composition for treating skin injury, preparation method of its ointment and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101126256A CN101690760B (en) | 2009-10-12 | 2009-10-12 | Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101690760A CN101690760A (en) | 2010-04-07 |
| CN101690760B true CN101690760B (en) | 2011-09-07 |
Family
ID=42079509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101126256A Active CN101690760B (en) | 2009-10-12 | 2009-10-12 | Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN101690760B (en) |
| WO (1) | WO2011044736A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550404A (en) * | 2013-10-23 | 2014-02-05 | 福建省中医药研究院 | Burn and scald ointment and preparation method thereof |
| CN105147832A (en) * | 2015-09-17 | 2015-12-16 | 王展飞 | External traditional Chinese medicine for treating burns and scalds and preparation method thereof |
| CN113577175A (en) * | 2021-08-13 | 2021-11-02 | 三明善草庵生物科技有限公司 | Traditional Chinese medicine external cream for treating upper respiratory tract infection and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1133441C (en) * | 2000-06-30 | 2004-01-07 | 谭高良 | Medicine prescription of treating burn |
| CN1176675C (en) * | 2001-03-08 | 2004-11-24 | 祝雨清 | Burn treating medicine and its prepn |
-
2009
- 2009-10-12 CN CN2009101126256A patent/CN101690760B/en active Active
- 2009-10-30 WO PCT/CN2009/074713 patent/WO2011044736A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CN101690760A (en) | 2010-04-07 |
| WO2011044736A1 (en) | 2011-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| WO2017206758A1 (en) | Topical pharmaceutical composition for treating multiple forms of skin wounds and manufacturing method thereof | |
| CN103751633B (en) | A kind of Chinese medicine composition and its preparation method treating Varicose veins of lower extremity | |
| CN108186711A (en) | Promote the pharmaceutical composition of wound healing | |
| CN101703603A (en) | External-use ointment for treating empyrosis and preparation method thereof | |
| CN110292602A (en) | Yellow burn oil formula of a kind of compound five and preparation method thereof | |
| CN101049466B (en) | Ointment of Chinese herbal medicine for treating burn and scald without pain, and scar, and preparation method | |
| CN101837082B (en) | Chinese preparation for treating burn without leaving scar | |
| CN106310061A (en) | Skin-healing antipruritic traditional Chinese medicine composition and preparation method thereof | |
| CN101690760B (en) | Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof | |
| CN105362410B (en) | Traditional Chinese medicine preparation for treating burns and scalds and preparation method | |
| CN105477129A (en) | External-use plaster for psoriasis and preparation method thereof | |
| CN103721138B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating rosacea | |
| CN102872335A (en) | Externally used Chinese medicine preparation for curing diabetic foot and preparation method thereof | |
| CN103920124B (en) | A kind of sterilizing skin-protective kibe ointment | |
| CN105147881A (en) | Compound menthol balm for treating burns | |
| CN107714834A (en) | A kind of composition of camellia oil preparation for external use, preparation method and applications | |
| CN104055720A (en) | Itch-relieving and skin-caring lotion | |
| CN104435730A (en) | Externally applied traditional Chinese medicine ointment for treating skin ulcer | |
| CN101590125B (en) | Medicament for treating empyrosis and using method thereof | |
| CN112826865B (en) | Skin disinfection spray preparation | |
| CN102813828B (en) | Stropanthus divericatus for treating external wounds | |
| CN102178795B (en) | External medicine for treating burns and scalds and preparation method of medicine | |
| CN106474236A (en) | A kind of treat pharmaceutical composition of pruitus and preparation method thereof | |
| CN106474388A (en) | A kind of clearing heat and expelling damp, antipruritic pharmaceutical composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170630 Address after: 362212 room 4, building 1701, West residence, Chi Zhen Town, Quanzhou, Fujian Patentee after: Chen Chengquan Address before: High rock village 365000 Fujian province Sanming City Meilie District 70 room 707 Patentee before: Zeng Qintai |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20211104 Address after: Floor 1-2, No.4 workshop, No.9 ground, Liantang food processing park, Ninghua County, Sanming City, Fujian Province, 365400 Patentee after: Ninghua Huiyuan Biotechnology Co.,Ltd. Address before: 362212 room 1701, building 4, Xizhai community, Chidian Town, Quanzhou City, Fujian Province Patentee before: Chen Chengquan |
|
| TR01 | Transfer of patent right |