CN103550404A - Burn and scald ointment and preparation method thereof - Google Patents
Burn and scald ointment and preparation method thereof Download PDFInfo
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- CN103550404A CN103550404A CN201310503037.1A CN201310503037A CN103550404A CN 103550404 A CN103550404 A CN 103550404A CN 201310503037 A CN201310503037 A CN 201310503037A CN 103550404 A CN103550404 A CN 103550404A
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Abstract
The invention provides a burn and scald ointment. The ointment is prepared from the following components in parts by weight: 8 parts of rosa cymosa, 2 parts of fresh mulberry leaf, 3 parts of water extract paste of polygonum cuspidatum, and 4 parts of tea oil. A method for preparing the burn and scald ointment comprises the following steps: respectively washing the 8 parts of fresh rosa cymosa and 2 parts of mulberry leaf, freeze-drying, and performing superfine grinding into over 300-mesh particles by using a superfine grinder; decocting and extracting the 3 parts of polygonum cuspidatus at normal pressure for three times and 30 minutes each time; combining and filtering the extracts in three times, and concentrating the filtrate at normal pressure to thick paste to obtain the water extract paste; mixing the rosa cymosa and mulberry leaf treated in the step 1 and the water extract paste, uniformly stirring, and adding 4 parts of tea oil to prepare ointment; preserving at a low temperature. The burn and scald ointment is simple in process and low in cost, can remarkably promote new skin generation to promote the wound to be quickly healed, is quick in response and short in course of treatment, and does not have toxic or side effect.
Description
Technical field
The present invention is specifically related to a kind of ointment for burns and scalds, and the preparation method of this ointment for burns and scalds.
Background technology
Burn and scald is because boiling water, steam, flame, chemical substance etc. directly act on a kind of acute injury that human body causes, it is common surgical disease, feature is that foeign element acts on after human body, there is local response in injury, according to the length of heating power size and action time is different, occurs different clinical symptoms immediately.Once burnt: damage is limited to epidermis shallow-layer, and symptom is that illing skin is rubescent, pain is inviolent, can normal healing, without cicatrix; Shallow two degree are burnt: damage stomach epidermis and corium upper three minute one, symptom is that affected part redness is got blister, and can have an intense pain and burning sensation, can normal healing, without cicatrix or slight cicatrix; Dark two degree are burnt: damage as epidermis and corium deep, symptom is that affected part is rubescent, play the large blister of white, because teleneuron is partially damaged, more shallow two degree of pain want light, can normal healing, and can scar; Third-degree burn: whole skin injurys, affected part is hide-like black eschar or pale, can have flow liquid phenomenon, and because most of teleneuron damages, this type of bright the wounded is often without affected part pain; Four degree are burnt: have even skeletal injury of subcutaneous tissue, muscle, can cause amputation; Five degree are burnt: most of subcutaneous tissue is burnt, and exposes muscular tissue, and sometimes to burn be fatal to five degree; Six degree are burnt: nearly all meat fiber disappears, and skeleton is burnt, normally fatal.
The method of western medical treatment burn and scald normally adopts debridement, sterilization, wrapping and operation, and its course for the treatment of is long, and healing is slow, and expense is high, and scar more.Treatment by Chinese herbs burn and scald has safety, and can play the resultant effect of heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation, anti-inflammatory analgetic; Be characterized in: 1, folk remedy; 2, formula is simple; 3, or limbs three degree following burn and scald disease little for area light, moderate; 4, can effectively promote epithelial tissue growth, make wound healing, preventing from scar; The effect 5, with clearing away heat to alleviate pain, erosion prevention and muscle growing, instant effect, short treating period, has no side effect.
Summary of the invention
One of technical problem to be solved by this invention is to provide a kind of ointment for burns and scalds, can significantly promote the generation of newborn skin, and wound surface is healed very soon.
The present invention is what one of to solve the problems of the technologies described above by the following technical programs: a kind of ointment for burns and scalds, comprises following each composition: the dry cream of water extraction of the fresh mulberry leaf of the Smallfruit Rose Root of 8 weight portions, 2 weight portions, the Rhizoma Polygoni Cuspidati of 3 weight portions, the Oleum Camelliae of 4 weight portions.
Further, the dry ointment preparation of the water extraction of described Rhizoma Polygoni Cuspidati is as follows: the Rhizoma Polygoni Cuspidati water normal pressure of 3 weight portions is decocted and extracted three times, and each 30min, then three extracting solution are merged and filtered, filtrate normal pressure is condensed into thick paste shape, obtains the dry cream of water extraction.
Two of technical problem to be solved by this invention is to provide a kind of preparation method of described ointment for burns and scalds, and technique is simple, and adult is cheap.
The present invention be solve the problems of the technologies described above by the following technical programs two: a kind of preparation method of described ointment for burns and scalds, comprises the following steps:
Step 1: fresh Smallfruit Rose Root 8 weight portions, Folium Mori 2 weight portions are cleaned up respectively, lyophilization, more than super micron mill micronizing to 300 order, standby;
Step 2: the Rhizoma Polygoni Cuspidati water normal pressure of 3 weight portions is decocted and extracted three times, each 30min, then three extracting solution are merged and filtered, filtrate normal pressure is condensed into thick paste shape, obtains the dry cream of water extraction, standby;
Step 3: Smallfruit Rose Root, Folium Mori and the dry cream of described water extraction of processing gained through step 1 are mixed into mud uniform stirring, then add the Oleum Camelliae of 4 weight portions, furnishing paste, cryopreservation.
Further, the cryopreservation temperature in described step 3 is below 5 °.
Beneficial effect of the present invention is: formula is simple, technique is simple, and adult is cheap; The ointment for burns and scalds making can significantly promote the generation of newborn skin, and wound surface is healed very soon, instant effect, short treating period, has no side effect.
Accompanying drawing explanation
The invention will be further described in conjunction with the embodiments with reference to the accompanying drawings.
Fig. 1 is the wound surface skin schematic diagram that in the present invention, model group III degree is scalded different number of days after Pseudomonas Aeruginosa Infection.
Fig. 2 is the wound surface skin schematic diagram of different number of days before the administration of positive drug in the present invention (JINGWANHONG) group and after administration.
Fig. 3 is the wound surface skin schematic diagram of different number of days before the administration of ointment for burns and scalds group and after administration in the present invention.
Fig. 4 is rats in normal control group dermal pathology section schematic diagram in the present invention.
Fig. 5 is model group rat wound site dermal pathology section schematic diagram in the present invention.
Fig. 6 is positive drug in the present invention (JINGWANHONG) group rat wound site dermal pathology section schematic diagram.
Fig. 7 is ointment for burns and scalds group rat wound site dermal pathology section schematic diagram in the present invention.
The specific embodiment
, comprise following each composition: the dry cream of water extraction of the fresh mulberry leaf of the Smallfruit Rose Root of 8 weight portions, 2 weight portions, the Rhizoma Polygoni Cuspidati of 3 weight portions, the Oleum Camelliae of 4 weight portions.
The dry ointment preparation of water extraction of described Rhizoma Polygoni Cuspidati is as follows: the Rhizoma Polygoni Cuspidati water normal pressure of 3 weight portions decocted and extracted three times, and each 30min, then three extracting solution are merged and filtered, filtrate normal pressure is condensed into thick paste shape, obtains the dry cream of water extraction.
The preparation method of described ointment for burns and scalds, comprises the following steps:
Step 1: fresh Smallfruit Rose Root 8 weight portions, Folium Mori 2 weight portions are cleaned up respectively, lyophilization, more than super micron mill micronizing to 300 order, standby;
Step 2: the Rhizoma Polygoni Cuspidati water normal pressure of 3 weight portions is decocted and extracted three times, each 30min, then three extracting solution are merged and filtered, filtrate normal pressure is condensed into thick paste shape, obtains the dry cream of water extraction, standby;
Step 3: Smallfruit Rose Root, Folium Mori and the dry cream of described water extraction of through step 1, processing gained are mixed into mud uniform stirring, then add the Oleum Camelliae of 4 weight portions, furnishing paste, cryopreservation, and cryopreservation temperature is below 5 °.
Investigate described ointment for burns and scalds rat III degree is scalded to Pseudomonas Aeruginosa Infection therapeutical effect
One, experiment material:
(1) be subject to reagent:
Ointment for burns and scalds; JINGWANHONG RUANGAO (business men is Tianjin Darentang Wanhong Pharmaceutical Co., Ltd).
(2) animal subject:
28 of clean level SD rats, body weight 220-280g, male, Zhejiang Province's Experimental Animal Center provides, credit number: SCXK (Zhejiang) 2008-0033.
(3) reagent:
Anesthetics: chloral hydrate, Chemical Reagent Co., Ltd., Sinopharm Group produces, lot number: 20090724.
Iodine tincture, lot number: 08041111.
0.9% sodium chloride injection: Otsuka Pharmaceutical (China) Co., Ltd., lot number: 9F97G4.
Benzylpenicillin sodium for injection (powder): Huabei Pharmaceutic Co., Ltd, specification is 800,000 U.
Two, experimental technique:
16 of clean level male SD rats, body weight 220-280g, is divided into 4 groups, 4 every group, is respectively: Normal group, model control group, positive drug (JINGWANHONG) group and ointment for burns and scalds group.Except Normal group, animal is with 3%(m/V) chloral hydrate intraperitoneal anesthesia, by depilatory sodium sulfide depilation for the metastomium skin of rat spinal column both sides, area is about 10% left and right that 3cm * 3cm(accounts for body surface area), use warm water cleaning depilatory, see the abnormal phenomenas such as skin zero damage, redness, erythra.After being padded on and boiling in 100 ℃ of boiling water with 3cm * 3cm cotton yarn, be placed in immediately in depilation district, pressurization 30s makes deep third degree scalding model.Perusal: visible wound surface skin is transparent, and some granular punctation, is then vesicular protuberance.Then intraperitoneal injection of saline (40ml/kg) shock immediately, wound surface is coated with iodine tincture infection.24h after scalding, giving the bacillus pyocyaneus bacterium liquid 4ml/kg(colony forming unit number of rats by intraperitoneal injection exponential phase is 8 * 10
9/ ml) cause severe sepsis.Observe after 24h, see that wound surface has obvious scorching pathological changes: purplish red hyperemia, edema etc.Respectively organize subsequently rat and regularly give relative medicine in part every day: dose is 1g/, penicillin 40,000 U/0.5ml/ only.Left and right hindlimb muscle is respectively injected penicillin 100,000 U/1.2ml/ only (80,000 U/ml) simultaneously.Be administered once every day, successive administration 14 days, and after each coating, wound surface covers with gauze, not administration of model group.Each group is taken pictures after the 1st day, the 2nd day, the 3rd day, the 7th day, the 14th day after (the 0th day) and administration respectively before administration, and (model group is all dead at the 6th day, therefore list the photo of the 0th, 1,2,3,4,5 day), record the healing state of rat wound site.Day by day observe activity, feed, drinking-water, wound healing, natural death and other abnormal conditions of every rat, observe and record mortality rate, within 14 days, finish rear Wound healing rate (%) ((original wound surface area-wound surface area does not heal)/original wound surface area) and decrustation time (time coming off completely for scald place crust).After medication 14d, sacrificed by decapitation animal, takes respectively each experimental rat wound site skin, and pathological section carries out histopathologic examination.Under microscope, observation and comparison is respectively organized the healing state of rat wound surface.
Three, experimental result:
Table 1 is respectively organized healing time, decrustation time and Wound healing rate
| ? | Mortality rate | Wound healing rate (%) | The decrustation time (my god) |
| Model group | 100% | - | - |
| JINGWANHONG |
0% | 61.4±0.08 | 12.0±0.82 |
| Ointment for burns and |
0% | 71.8±0.04 | 12.3±0.5 |
The experimental result of table 1 shows, model group rat is all dead, positive drug (JINGWANHONG) group and none death of ointment for burns and scalds group, Wound healing rate after 14 days is that ointment for burns and scalds group is greater than positive drug (JINGWANHONG) group, be the healing rate that the healing rate of ointment for burns and scalds group of the present invention is better than JINGWANHONG group, the Wound healing rate of ointment for burns and scalds group and JINGWANHONG group be significant difference.The decrustation time, ointment for burns and scalds group and JINGWANHONG group approached.
Refer to Fig. 1-3, Fig. 1 is the wound surface skin schematic diagram of different number of days (d) after model group III degree scald Pseudomonas Aeruginosa Infection; The wound surface skin schematic diagram of different number of days after (0 day) and administration before the administration of the positive medicine of Fig. 2 (JINGWANHONG) group; Fig. 3 is the wound surface skin schematic diagram of different number of days after (0 day) and administration before the administration of ointment for burns and scalds group.Experimental result shows, before administration, (0 day) is respectively organized Rat Scald Model and is successfully prepared, red and swollen and inflammatory conditions is similar; Not administration of model group, the red and swollen phenomenon of rat back wound surface is aggravated day by day, presents atropurpureus lump by the 5th day, and within the 6th day, model group rat is all dead; Each administration group administration after 1,2,3 days red and swollen situation be slightly improved, wound surface incrustation, positive drug after 7 days (JINGWANHONG) group is formed face with ointment for burns and scalds and is all obviously dwindled, and scald position crusts and come off completely for two groups, and positive drug group and ointment for burns and scalds is formed face and is substantially healed after 14 days.
To scalding the histological examination of Pseudomonas Aeruginosa Infection rat model wound surface dermal pathology
One, experimental technique:
Above-mentioned experiment finishes, and gets each experimental rat wound site skin, and pathological section carries out histopathologic examination.
Rat wound surface skin is fixed through 10% formalin solution, routine is drawn materials, dehydration, paraffin embedding, film-making (4 μ m are thick), HE dyeing, by pathology professional, under optical microscope, read sheet, different according to pathological changes light and heavy degree, be labeled as successively "-", "+", " ++ ", " +++ ", " ++++" represents, wherein "-" is without obviously changing, " ++++" be serious pathological change.
Two, experimental result
Table 2 is respectively organized rat model wound surface dermal pathology situation
From the result of table 2, can draw:
(1) blank group:
Rat skin structural integrity, coating squamous epithelial cancer is complete, and cuticular layer is without thickening, and intradermal is congested without vasodilation, cell infiltration, hair follicle, sebaceous gland structural integrity.
(2) model group:
Part rat skin structural integrity, coating squamous epithelial cancer is complete, cuticular layer is without thickening, part rat skin destroys, and ulcer reaches flesh layer deeply, and some epidermises are shown in the incrustation being dispersed in, subcutaneous dropsy (++), see new capillary vessel (+), more cell infiltration (+++), hair follicle, sebaceous gland structure disappear, and visible collagen fiber form (+).
(3) positive drug (JINGWANHONG) group:
Part rat skin structural integrity, coating squamous epithelial cancer is complete, cuticular layer is without thickening, part rat skin destroys, and some epidermises cover, and see the incrustation being dispersed in, the subcutaneous edema that has no, see a small amount of new capillary vessel (+), a small amount of cell infiltration (+), hair follicle, sebaceous gland structure disappear, visible more collagen fiber (++).
(4) ointment for burns and scalds group
Part rat skin structural integrity, coating squamous epithelial cancer is complete, cuticular layer is without thickening, part rat skin destroys, ulcer, and some epidermises are shown in the incrustation being dispersed in, the subcutaneous edema that has no, see new capillary vessel (+), cell infiltration (+), hair follicle, sebaceous gland structure disappear, and visible collagen fiber form (+++).
Visible ointment for burns and scalds group and JINGWANHONG group, compare the improvement all having in various degree with model group, wherein the form of ointment for burns and scalds group is slightly better than JINGWANHONG group.
Referring again to Fig. 4-7, Fig. 4, Fig. 5, Fig. 6 and Fig. 7 are respectively rats in normal control group dermal pathology section schematic diagram, model group rat wound site dermal pathology section schematic diagram, positive drug (JINGWANHONG) group rat wound site dermal pathology section schematic diagram, ointment for burns and scalds group rat wound site dermal pathology section schematic diagram.From Fig. 4-7, rats in normal control group skin texture is complete, and coating squamous epithelial cancer is complete, and cuticular layer is without thickening, and intradermal is congested without vasodilation, cell infiltration, hair follicle, sebaceous gland structural integrity.Model group rat skin destroys, and ulcer reaches flesh layer deeply, and some epidermises are shown in the incrustation being dispersed in, and subcutaneous dropsy is shown in that new capillary vessel, the more thin breast of inflammation infiltrate, and hair follicle, sebaceous gland structure disappear, and visible collagen fiber form.Positive drug (JINGWANHONG) group and ointment for burns and scalds group subcutaneous dropsy disappear, see new capillary vessel, and visible collagen fiber form, and ointment for burns and scalds group collagen fiber formation degree is better than positive drug (JINGWANHONG) group, show that ointment for burns and scalds group can significantly promote the generation of newborn skin, the form of ointment for burns and scalds group is slightly better than positive drug (JINGWANHONG) group.
Claims (4)
1. an ointment for burns and scalds, is characterized in that: comprise following each composition: the dry cream of water extraction of the fresh mulberry leaf of the Smallfruit Rose Root of 8 weight portions, 2 weight portions, the Rhizoma Polygoni Cuspidati of 3 weight portions, the Oleum Camelliae of 4 weight portions.
2. a kind of ointment for burns and scalds as claimed in claim 1, it is characterized in that: the dry ointment preparation of water extraction of described Rhizoma Polygoni Cuspidati is as follows: the Rhizoma Polygoni Cuspidati water normal pressure of 3 weight portions is decocted and extracted three times, each 30min, again three extracting solution are merged and filtered, filtrate normal pressure is condensed into thick paste shape, obtains the dry cream of water extraction.
3. a preparation method for ointment for burns and scalds as claimed in claim 1, is characterized in that: comprise the following steps:
Step 1: fresh Smallfruit Rose Root 8 weight portions, Folium Mori 2 weight portions are cleaned up respectively, lyophilization, more than super micron mill micronizing to 300 order, standby;
Step 2: the Rhizoma Polygoni Cuspidati water normal pressure of 3 weight portions is decocted and extracted three times, each 30min, then three extracting solution are merged and filtered, filtrate normal pressure is condensed into thick paste shape, obtains the dry cream of water extraction, standby;
Step 3: Smallfruit Rose Root, Folium Mori and the dry cream of described water extraction of processing gained through step 1 are mixed into mud uniform stirring, then add the Oleum Camelliae of 4 weight portions, furnishing paste, cryopreservation.
4. the preparation method of ointment for burns and scalds as claimed in claim 3, is characterized in that: the cryopreservation temperature in described step 3 is below 5 °.
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| CN201310503037.1A CN103550404A (en) | 2013-10-23 | 2013-10-23 | Burn and scald ointment and preparation method thereof |
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| CN201310503037.1A CN103550404A (en) | 2013-10-23 | 2013-10-23 | Burn and scald ointment and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690760A (en) * | 2009-10-12 | 2010-04-07 | 曾钦台 | Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof |
| CN101797303A (en) * | 2010-02-02 | 2010-08-11 | 李喜珍 | Chinese medicinal plaster for treating burns and scalds |
-
2013
- 2013-10-23 CN CN201310503037.1A patent/CN103550404A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690760A (en) * | 2009-10-12 | 2010-04-07 | 曾钦台 | Pharmaceutical composition for treating trauma and preparation method and application of plaster thereof |
| CN101797303A (en) * | 2010-02-02 | 2010-08-11 | 李喜珍 | Chinese medicinal plaster for treating burns and scalds |
Non-Patent Citations (4)
| Title |
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| 唐桂德: "烧、烫伤", 《广西中医药》 * |
| 张兴燊: "虎杖水煎液对烫伤大鼠治疗作用的实验研究", 《时珍国医国药》 * |
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Application publication date: 20140205 |