CN106265814B - Cover the preparation method of application and the drug of watt Ji extract in preparation treatment scald medicament - Google Patents
Cover the preparation method of application and the drug of watt Ji extract in preparation treatment scald medicament Download PDFInfo
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- CN106265814B CN106265814B CN201610919293.2A CN201610919293A CN106265814B CN 106265814 B CN106265814 B CN 106265814B CN 201610919293 A CN201610919293 A CN 201610919293A CN 106265814 B CN106265814 B CN 106265814B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a kind of application for covering watt Ji extract in preparation treatment scald medicament and the preparation methods of the drug.Present invention discover that covering effective component of watt Ji as drug, and it was proved that, covering watt Ji has significant healing effect to scald, and wound is not easy the characteristics of staying scar more afterwards, also has the function of preventing scald wound from infecting, and scald wound can also be accelerated to form a scab, make Wound Contraction and wound healing, compared with existing common medicament for treating scald, there is better therapeutic effect, especially preventing because more having a clear superiority in body fluid exosmose caused by scalding.
Description
Technical field
The present invention relates to pharmaceutical technologies, especially cover watt Ji extract preparation treatment scald medicament in application and
The preparation method of the drug.
Background technique
Burn and scald is the histologic lesion due to caused by heat, chemical substance, light, electricity and radioactive ray etc., refers mainly to skin
And (or) mucosa injury, serious person can injure subcutaneous tissue, such as muscle, bone, joint even internal organ, therefore, be it is a kind of extremely
Complicated traumatic disease.
Western medicine then thinks that the cause of disease of burn and scald is due to high temperature, such as flame, boiling water, molten steel, steam；Chemical factor, such as
Strong acid, highly basic；Electric power factor, such as electric shock, lightning；Sexual factor, such as x-ray, atomic energy are radiated, local organization damage can be directly contributed
Evil is allowed to that denaturation, necrosis, inflammation or even structural constituent structure change occurs, and directly results in tissue destruction, function is lost.
Clinically the degree habituation of burn and scald uses " three degree four points " method.It is divided by degree of injury difference:
I degree burn and scald: only injuring epidermis, and local skin is rubescent, therefore also known as erythema burn and scald.There are mild swelling and pain
Bitterly, erythema disappears after general 2~3 days, and the epidermal cell of local necrosis is by deep layer cells proliferation for repairing.Clinically there is furfur,
Scar is not stayed, pigmentation that sometimes there may be is slight.
Light degree Ⅱ burn and scald: injuring holostrome epidermis and high dermis, and epidermis is separated with corium, diffusate accumulation therebetween and
Form bubble.The visible light red color substrate of bubble excoriation, there is uniform cerise spot thereon, to fill in papillary layer of corium
The plexus vasculosus section of blood.Pi Wengao, oozes out more, and swelling is obvious, and due to nerve ending is stimulated and sharp ache, felt
It is quick.It is dry silly to form within 3~4 days a thin layer brown color.Such as without infection, then by the hyperplasia healing in 10~14 days of residual epidermis, have after healing
Pigmentation, but without scar.
Deep II degree of burn and scald: corium deep layer is injured, but has appendages of skin residual.Bubble can also be formed, but because of rotten table
Skin tissue is slightly thick, therefore bubble is smaller or more flat thin, and substrate is at pale red or red and white or visible netted vascular embolization；Feel
Blunt, Pi Wen is slightly lower, and surface sepage is less, but bottom swelling is obvious.1~2 day surface of a wound is gradual drying after wound, such as simultaneously without infection
Disease is sent out, can be healed within 3~4 weeks；There are scars after healing, and such as infected, then the remaining appendages of skin are often destroyed, and become III
Degree.
III degree of burn and scald: injuring skin holostrome, even up to subcutaneously, muscle, bone etc., cutaneous necrosis.It can shape after dehydration
Coking is silly, therefore also known as burnt silly property burn and scald.The surface of a wound can be in pale, sepia or burned black, charing or visible dendroid embolism blood
Pipe；Part is hardened, dries, without blister.But subcutaneous compartment has big quantity of fluid to gather, and coke is silly, and 2~4 weeks gradually generally after wound
Granulation wound is separated and exposed, in addition to compared with small area energy self-heal, generally all needs to heal through dermatoplasty, be stayed after healing
There are scar or deformity, cannot perspire.
Treating the common chemicals of burn and scald now is mostly antibiotic such as penicillin, cephalo, sulphadiazine etc., mainly
Play prophylactic treatment Burn Infection, anti-inflammatory, antibacterial therapeutic effect.
Covering watt Ji Cirsium leducei (Franch.) Levl is compositae plant, perennial herb.Main distribution Guizhou,
The ground such as Guangdong, Guangxi and Yunnan.It is grown on hillside hayashishita or border, meadow, 500-1500 meters of height above sea level.Covering watt Ji root has clearly
Heat, removing toxic substances, analgesic, antibacterial anti-inflammatory and other effects.
Summary of the invention
The object of the present invention is to provide a kind of applications for covering watt Ji extract in preparation treatment scald medicament.
Another object of the present invention is: providing the method for treating scald medicament using watt Ji extract preparation is covered.
The present invention is implemented as follows: covering application of watt Ji extract in preparation treatment scald medicament.
Watt Ji extract that covers is the water extract or polar extract for covering watt Ji.
The method for treating scald medicament using watt Ji extract preparation is covered,
1) watt Ji fresh goods will be covered or dry product adds water to cook, decocted 3 times, each 2h by solid-liquid ratio 1:10, filtrate is extracted in filtering,
Merging filtrate is made water extract medicinal extract, saves at 4 DEG C by filtrate after being concentrated under reduced pressure；
2) ethyl alcohol that watt Ji fresh goods or dry product and quality percentage are 75% will be covered to flow back in the ratio of solid-liquid ratio 1:10
It extracts 3 times, filtering, after merging filtrate；It is successively extracted with petroleum ether, ethyl acetate, n-butanol, and merges each layer extract liquor, obtained
Petroleum ether layer, ethyl acetate layer and n-butanol layer extracting solution, it is spare that concentration obtains polarity medicinal extract；
3) water extract medicinal extract and polarity medicinal extract are individually packed.
Water extract medicinal extract and polarity medicinal extract are individually packaged as Chinese medical concrete.
The mixing medicinal extract for taking individual water extract medicinal extract, individual polarity medicinal extract or water extract medicinal extract and polarity medicinal extract, adds
Enter pharmaceutically acceptable adjuvant and powder, film, finish, aerosol, tincture, ointment, externally-applied liniment, suspension, molten is made
Liquor or emplastrum.
1 is described in detail by following zoopery to a watt therapeutic effect for Ji scald is covered.
1.1 cover a watt Ji water extract treatment scald animal experiment study
SPF grades small white mouse 48, mouse is randomly divided into 4 groups, respectively water by weight by half male and half female, 18~22g of weight
Decoction group, jingwanhong soft plaster group, flamazine group, blank group, every group mouse 12.It is anaesthetized, is used in combination using nhalant anesthesia
8% vulcanized sodium loses hair or feathers.After for 24 hours, surface of a wound production is carried out to undamaged epilating area.The desk-top super temperature control of YLS-5Q is scalded
The pressure for hurting instrument is adjusted to 500g, and temperature setting is 80 DEG C.Diameter perming for 2cm is selected, perming pair for requirement is up to
The quasi- scald area of quasi- mouse, timing 12s complete III degree of scald wound production.After mouse causes injury 2h, mouse is administered and is controlled
It treats.It is divided into water decoction group, positive controls are that jingwanhong soft plaster group and flamazine group, blank group are not administered.It is administered daily one
It is secondary, after administration, simple process is carried out to guarantee the validity of drug to the surface of a wound.Successive administration 12 days, observe the healing feelings of the surface of a wound
Condition.The healing rate of wounds in mice is calculated according to the surface of a wound area change of mouse.The calculation formula of Wound healing rate is as follows:
1.2 cover a watt Ji n-butanol polar fraction treatment scald animal experiment study
SPF grades small white mouse 48, mouse is randomly divided into 4 groups by weight, is positive respectively by half male and half female, 18~22g of weight
Butanol group, jingwanhong soft plaster group, flamazine group, blank group, every group mouse 12.It is anaesthetized, is used in combination using nhalant anesthesia
8% vulcanized sodium loses hair or feathers.After for 24 hours, surface of a wound production is carried out to undamaged epilating area.The desk-top super temperature control of YLS-5Q is scalded
The pressure for hurting instrument is adjusted to 500g, and temperature setting is 80 DEG C.Diameter perming for 2cm is selected, perming pair for requirement is up to
The quasi- scald area of quasi- mouse, timing 12s complete III degree of scald wound production.After mouse causes injury 2h, mouse is administered and is controlled
It treats.It is divided into water decoction group, positive controls are that jingwanhong soft plaster group and flamazine group, blank group do not give medicine.It is administered daily
Once, after administration, simple process is carried out to guarantee the validity of drug to the surface of a wound.Successive administration 12 days, observe the healing of the surface of a wound
Situation.The healing rate of wounds in mice is calculated according to the surface of a wound area change of mouse.The calculation formula of Wound healing rate is as follows:
1.3 cover a watt Ji ethyl acetate polar fraction treatment scald animal experiment study
SPF grades small white mouse 48, mouse is randomly divided into 4 groups by weight, is positive respectively by half male and half female, 18~22g of weight
Butanol group, jingwanhong soft plaster group, flamazine group, blank group, every group mouse 12.It is anaesthetized, is used in combination using nhalant anesthesia
8% vulcanized sodium loses hair or feathers.After for 24 hours, surface of a wound production is carried out to undamaged epilating area.The desk-top super temperature control of YLS-5Q is scalded
The pressure for hurting instrument is adjusted to 500g, and temperature setting is 80 DEG C.Diameter perming for 2cm is selected, perming pair for requirement is up to
The quasi- scald area of quasi- mouse, timing 12s complete III degree of scald wound production.After mouse causes injury 2h, mouse is administered and is controlled
It treats.It is divided into water decoction group, positive controls are that jingwanhong soft plaster group and flamazine group, blank group do not give medicine.It is administered daily
Once, after administration, simple process is carried out to guarantee the validity of drug to the surface of a wound.Successive administration 12 days, observe the healing of the surface of a wound
Situation.The healing rate of wounds in mice is calculated according to the surface of a wound area change of mouse.The calculation formula of Wound healing rate is as follows:
1.4 cover a watt Ji petroleum ether polar fraction treatment scald animal experiment study
SPF grades small white mouse 48, mouse is randomly divided into 4 groups, respectively stone by weight by half male and half female, 18~22g of weight
Oily ether group, jingwanhong soft plaster group, flamazine group, blank group, every group mouse 12.It is anaesthetized, is used in combination using nhalant anesthesia
8% vulcanized sodium loses hair or feathers.After for 24 hours, surface of a wound production is carried out to undamaged epilating area.The desk-top super temperature control of YLS-5Q is scalded
The pressure for hurting instrument is adjusted to 500g, and temperature setting is 80 DEG C.Diameter perming for 2cm is selected, perming pair for requirement is up to
The quasi- scald area of quasi- mouse, timing 12s complete III degree of scald wound production.After mouse causes injury 2h, mouse is administered and is controlled
It treats.It is divided into water decoction group, positive controls are that jingwanhong soft plaster group and flamazine group, blank group do not give medicine.It is administered daily
Once, after administration, simple process is carried out to guarantee the validity of drug to the surface of a wound.Successive administration 12 days, observe the healing of the surface of a wound
Situation.The healing rate of wounds in mice is calculated according to the surface of a wound area change of mouse.The calculation formula of Wound healing rate is as follows:
2 experimental results
2.1 cover a watt Ji water extract treatment scald Results of Animal
Experimental studies results show: comparing with positive controls, water decoction group has better therapeutic effect.Especially anti-
Only because more having a clear superiority in body fluid exosmose caused by scalding.Therapeutic effect of the water decoction group to III degree of scald wound
It is significantly stronger than jingwanhong soft plaster group and flamazine group, and is restored first 6 days in the surface of a wound, water decoction group can speed up the recovery of the surface of a wound,
Significantly improve the healing rate of the surface of a wound.As a result as shown in table 1, table 2, attached drawing 1, attached drawing 2.
Area change (the cm of table 1 mouse, III degree of scald wound2)
(note: comparing with blank group, P < 0.05 * * P < 0.01, *；Compare with jingwanhong soft plaster, ++ p < 0.01 ,+p < 0.05；Same sulphur
Amic metadiazine silver compares, ▲ ▲ p < 0.01, ▲ p < 0.05)
2 mouse of table, III degree of wound tissue healing rate (%)
(note: comparing with blank group, P < 0.05 * * P < 0.01, *；Compare with jingwanhong soft plaster, ++ p < 0.01 ,+p < 0.05；Same sulphur
Amic metadiazine silver compares, ▲ ▲ p < 0.01, ▲ p < 0.05)
2.2 cover a watt Ji n-butanol polar fraction treatment scald Results of Animal
Experimental studies results show: n-butanol group and positive controls show the therapeutic effect to scald, and in reality
It tests early period, n-butanol group is with the obvious advantage, as a result as shown in table 3, table 4, attached drawing 3, attached drawing 4.
Area change (the cm of table 3 mouse, III degree of scald wound2)
(note: comparing with blank group, P < 0.05 * * P < 0.01, *；Compare with jingwanhong soft plaster, ++ p < 0.01 ,+p < 0.05；Same sulphur
Amic metadiazine silver compares, ▲ ▲ p < 0.01, ▲ p < 0.05)
4 mouse of table, III degree of wound tissue healing rate (%)
(note: comparing with blank group, P < 0.05 * * P < 0.01, *；Compare with jingwanhong soft plaster, ++ p < 0.01 ,+p < 0.05；Same sulphur
Amic metadiazine silver compares, ▲ ▲ p < 0.01, ▲ p < 0.05)
2.3 cover a watt Ji ethyl acetate polar fraction treatment scald Results of Animal
Experimental studies results show: ethyl acetate group and positive controls show the therapeutic effect to scald, and control
Therapeutic effect is suitable, as a result such as table 5, table 6, attached drawing 5, shown in attached drawing 6.
Area change (the cm of table 5 mouse, III degree of scald wound2)
(note: comparing with blank group, P < 0.05 * * P < 0.01, *；Compare with jingwanhong soft plaster, ++ p < 0.01 ,+p < 0.05；Same sulphur
Amic metadiazine silver compares,
▲ ▲ p < 0.01, ▲ p < 0.05)
6 mouse of table, III degree of wound tissue healing rate (%)
(note: comparing with blank group, P < 0.05 * * P < 0.01, *；Compare with jingwanhong soft plaster, ++ p < 0.01 ,+p < 0.05；Same sulphur
Amic metadiazine silver compares, ▲ ▲ p < 0.01, ▲ p < 0.05)
2.4 cover a watt Ji petroleum ether polar fraction treatment scald Results of Animal
Experimental studies results show: comparing with blank group, petroleum ether group has certain healing to act on burn and scald, but effect
Lower than positive controls, as a result such as table 7, table 8, attached drawing 7, shown in attached drawing 8.
Area change (the cm of table 7 mouse, III degree of scald wound2)
(note: comparing with blank group, P < 0.05 * * P < 0.01, *；Compare with jingwanhong soft plaster, ++ p < 0.01 ,+p < 0.05；Same sulphur
Amic metadiazine silver compares, ▲ ▲ p < 0.01, ▲ p < 0.05)
8 mouse of table, III degree of wound tissue healing rate (%)
(note: comparing with blank group, P < 0.05 * * P < 0.01, *；Compare with jingwanhong soft plaster, ++ p < 0.01 ,+p < 0.05；Same sulphur
Amic metadiazine silver compares, ▲ ▲ p < 0.01, ▲ p < 0.05)
It covers a watt Ji treatment scald Results of Animal to show: covering watt Ji water decoction and its alcohol extract opposed polarity position
Therapeutic effect is all had to scald, wherein water decoction effect is most obvious.To sum up, watt Ji is covered to the strong and weak sequence of the therapeutic effect of scald
Are as follows: water decoction group > jingwanhong soft plaster group > flamazine group >=ethyl acetate group > n-butanol group > petroleum ether group.
Present invention discover that effective component of watt Ji as drug is covered, and it was proved that, covering a watt Ji has scald
Significant healing effect, wound are not easy the characteristics of staying scar more afterwards, and also having prevents scald wound infection from working, and can also add
Fast scald wound incrustation, makes Wound Contraction and wound healing, compared with existing common medicament for treating scald, has preferably treatment effect
Fruit is especially preventing because more having a clear superiority in body fluid exosmose caused by scalding.
Detailed description of the invention
Attached drawing 1 is the area change curve graph of III degree of scald wound of mouse；
Attached drawing 2 is III degree of wound tissue healing rate curve graph of mouse；
Attached drawing 3 is the area change curve graph of III degree of scald wound of mouse；
Attached drawing 4 is III degree of wound tissue healing rate curve graph of mouse；
Attached drawing 5 is the area change curve graph of III degree of scald wound of mouse；
Attached drawing 6 is III degree of wound tissue healing rate curve graph of mouse；
Attached drawing 7 is the area change curve graph of III degree of scald wound of mouse；
Attached drawing 8 is III degree of wound tissue healing rate curve graph of mouse.
Specific embodiment
The embodiment of the present invention 1: preparing the method for treating scald medicament using watt Ji extract is covered,
1) watt Ji fresh goods will be covered or dry product adds water to cook, decocted 3 times, each 2h by solid-liquid ratio 1:10, filtrate is extracted in filtering,
Merging filtrate is made water extract medicinal extract, saves at 4 DEG C by filtrate after being concentrated under reduced pressure；
2) ethyl alcohol that watt Ji fresh goods or dry product and quality percentage are 75% will be covered to flow back in the ratio of solid-liquid ratio 1:10
It extracts 3 times, filtering, after merging filtrate；It is successively extracted with petroleum ether, ethyl acetate, n-butanol, and merges each layer extract liquor, obtained
Petroleum ether layer, ethyl acetate layer and n-butanol layer extracting solution, it is spare that concentration obtains polarity medicinal extract；
3) water extract medicinal extract and polarity medicinal extract are individually packed.
The embodiment of the present invention 2: the water extract medicinal extract and polarity medicinal extract that embodiment 1 is prepared are further processed；It takes
The mixing medicinal extract of individual water extract medicinal extract, individual polarity medicinal extract or water extract medicinal extract and polarity medicinal extract, addition pharmaceutically may be used
Powder, film, finish, aerosol, tincture, ointment, externally-applied liniment, suspension, solution or plaster is made in the adjuvant of receiving
Agent.
When in use, the drug Direct Uniform of preparation is directly applied to affected part, one time a day, wound is without cleaning.
Claims (3)
1. a watt Ji extract preparation treatment scald medicament method is covered in a kind of utilization, it is characterised in that:
1) watt Ji fresh goods will be covered or dry product adds water to cook, decocted 3 times, each 2h by solid-liquid ratio 1:10, filtrate is extracted in filtering, is merged
Filtrate is made water extract medicinal extract, saves at 4 DEG C by filtrate after being concentrated under reduced pressure；
2) ethyl alcohol that watt Ji fresh goods or dry product and quality percentage are 75% will be covered and carries out refluxing extraction 3 in the ratio of solid-liquid ratio 1:10
It is secondary, it filters, after merging filtrate；It is successively extracted with petroleum ether, ethyl acetate, n-butanol, and merges each layer extract liquor, obtain petroleum ether
Layer, ethyl acetate layer and n-butanol layer extracting solution, it is spare that concentration obtains polarity medicinal extract；
3) water extract medicinal extract and polarity medicinal extract are individually packed.
2. a watt Ji extract preparation treatment scald medicament method is covered in utilization according to claim 1, it is characterised in that: by water
Extract medicinal extract and polarity medicinal extract are individually packaged as Chinese medical concrete.
3. a watt Ji extract preparation treatment scald medicament method is covered in utilization according to claim 1, it is characterised in that: take list
The mixing medicinal extract of only water extract medicinal extract, individual polarity medicinal extract or water extract medicinal extract and polarity medicinal extract, addition can pharmaceutically connect
Powder, film, finish, aerosol, tincture, ointment, externally-applied liniment, suspension, solution or emplastrum is made in the adjuvant received.
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Non-Patent Citations (2)
| Title |
|---|
| 大蓟、魁蓟、覆瓦蓟的蒙花苷和大蓟苷含量比较;李治昊等;《中国中药杂志》;20130331;第38卷(第5期);第674-677页 |
| 覆瓦蓟根部挥发油成份及抗氧化活性的初步研究;杨周洁等;《山地农业生物学报》;20141231;第33卷(第5期);第32-34页 |
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