CN114832055A - Preparation method and application of medicine for controlling cancer pain - Google Patents
Preparation method and application of medicine for controlling cancer pain Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a medicine composition for controlling cancer pain, which is prepared from kusnezoff monkshood root, Tou Guxiang, caulis periplocae, Chinese alangium, sargentgloryvine stem, alocasia odorata, short-pedicel aconite root, rhizoma arisaematis, asiatic toddalia root, greater celandine and auxiliary materials. The traditional Chinese medicine composition has the effects of dispelling cold and relieving pain, promoting blood circulation and removing obstruction in channels, dispelling wind and eliminating dampness, clearing heat and removing toxicity, promoting qi circulation and relieving pain, and resolving hard mass and reducing swelling, can control cancer pain, and is suitable for people suffering from cancer and accompanied with severe cancer pain.
Description
The technical field is as follows:
the invention relates to a medicine (named as crossbow liquid medicine) for controlling cancer pain and a preparation method thereof, belonging to the technical field of medicines.
Background art:
cancer pain generally refers to pain caused directly by a tumor that invades or compresses nerve roots, nerve trunks, plexuses or nerves; invasion of the brain and spinal cord; tumors invade the periosteum or bone; invade parenchymal and hollow organs; invade or occlude the vasculature; local necrosis, ulcer, inflammation, etc. caused by tumor; all of which can cause severe pain. Pain caused during the course of tumor therapy is also considered cancer pain. Cancer pain is generally mainly treated by medicaments, and is orally taken as much as possible, so that the long-term administration is convenient, and the dependence and addiction can be reduced. Cancer pain is a sensation caused after information that a pain part needs to be repaired or regulated is transmitted to a nerve center, and is one of the main causes of pain of patients with advanced cancer. Among pain patients, 50% to 80% of pain is not effectively controlled for various reasons. The traditional Chinese medicine emphasizes the aspects of preventing and treating cancer pain by a method of treating the root cause, starting from the aspects of dispelling cold and relieving pain, promoting blood circulation and removing obstruction in channels, dispelling wind and eliminating dampness, clearing heat and detoxicating, promoting qi circulation and relieving pain, eliminating stagnation and reducing swelling, and the like, and solves the problem that western medicines only aim at treating pain by blocking nerves. And the traditional Chinese medicine has less side effect and higher safety than western medicine.
The invention content is as follows:
the technical problem to be solved by the invention is to provide a preparation method and application of a medicine (named as crossbow liquid medicine) for controlling cancer pain. The medicine has the effects of dispelling cold and relieving pain, promoting blood circulation and removing obstruction in collaterals, dispelling pathogenic wind and removing dampness, clearing heat and detoxicating, promoting qi circulation and relieving pain, resolving hard mass and subsiding swelling, can effectively control cancer pain, and is suitable for people suffering from cancer and accompanied with severe cancer pain.
In order to solve the technical problems, the invention adopts the following technical scheme:
a medicine for controlling cancer pain is prepared from (by weight parts) radix Aconiti Kusnezoffii 10-60, caulis et folium Gaultheriae Yunnanensis 20-100, caulis et folium Periplocae Forrestii 10-60, Chinese Alangium 5-50, caulis Sargentodoxae 20-100, Henry yam 10-60, radix Aconiti Brachypodi 5-40, radix Aconiti 10-60, rhizoma arisaematis 10-60, radix Toddaliae Asiaticae 10-60, herba Chelidonii 10-60 and adjuvants.
Specifically, the medicine for controlling cancer pain is prepared from 20-40 parts by weight of radix aconiti agrestis, 50-70 parts by weight of caulis periplocae, 20-40 parts by weight of periploca forrestii, 10-30 parts by weight of Chinese alangium, 50-70 parts by weight of sargentgloryvine stem, 20-40 parts by weight of alocasia cucullata, 5-15 parts by weight of short-pedicel aconite root, 20-40 parts by weight of radix aconiti, 10 parts by weight of rhizoma arisaematis, 20-40 parts by weight of asiatic toddalia root, 20-40 parts by weight of celandine and auxiliary materials.
More specifically, the medicinal liquid for controlling cancer pain is prepared from 30 parts by weight of radix aconiti agrestis, 60 parts by weight of caulis perllae, 30 parts by weight of caulis periplocae, 20 parts by weight of alangium chinense, 60 parts by weight of caulis sargentodoxae, 30 parts by weight of alocasia macrorrhiza, 10 parts by weight of short-pedicel aconite root, 30 parts by weight of radix aconiti, 10 parts by weight of rhizoma arisaematis, 30 parts by weight of asiatic toddalia root, 30 parts by weight of greater celandine and auxiliary materials.
The preparation method of the medicine for controlling cancer pain comprises the following steps: all the medicinal materials in the prescription are weighed according to the proportion, combined with the medicinal auxiliary materials acceptable in the medicaments, processed according to the conventional preparation method and prepared into the corresponding medicinal preparation.
The preparation method of the medicine for controlling cancer pain comprises the following steps: weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 1.5 times of 70% ethanol, soaking for 3 times, each time for 12 hours, collecting the leaching solution, standing for 24 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the traditional Chinese medicine composition.
The medicinal preparation is tincture, liniment or spray.
The tincture is prepared by the following steps: weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 1.5 times of 70% ethanol, soaking for 3 times, each time for 12 hours, collecting the leaching solution, standing for 24 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the traditional Chinese medicine composition.
The liniment is prepared by: weighing the raw materials according to the formula proportion, crushing into coarse powder, adding 2 times of 70% ethanol, soaking for 2 times, each time for 24 hours, collecting the leachate, standing for 48 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the traditional Chinese medicine composition.
The spray is prepared by the following steps: weighing the medicinal materials according to a formula proportion, crushing into coarse powder, adding 1 time of 70% ethanol, soaking for 2 times, collecting the leaching solution each time 18 hours, standing for 48 hours, filtering, adding ethanol with the original concentration to 1000ml from a filter, subpackaging in a pressure-resistant container, and installing a valve to obtain the traditional Chinese medicine composition.
When the pharmaceutical composition is prepared into a medicament, the medicament with unit dose can contain 0.1-1000mg of the pharmaceutical active substance, and the balance is pharmaceutically acceptable auxiliary materials. The pharmaceutically acceptable auxiliary materials can be 0.1-99.9% of the total weight of the preparation.
The medicine of the invention is prepared from kusnezoff monkshood root, Tou Guxiang, black bone vine, Chinese alangium, sargentgloryvine stem, alocasia macrorrhiza, short-pedicel aconite root, common monkshood mother root, arisaema tuber, asiatic toddalia root and celandine. The properties and the efficacies of the components are as follows: radix Aconiti Kusnezoffii is dried root tuber of Aconitum kusnezoffii Reichb of Ranunculaceae; digging when stem and leaf wither in autumn, removing fibrous root and silt, and drying; pungent, bitter and hot in flavor; it is toxic. Heart, liver, kidney, spleen meridians; has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain; can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, and anesthesia and pain relieving. The caulis et folium Gaultheria leucocarpae of Callicarpa of Ericaceae is whole plant or root of Gaultheria leucocarpa Bl. var. crenulata (Kurz) T.Z.Hsu; the plant Yunnan Baizhu is distributed in the Yangtze river basin and provinces in the south of China; pungent taste and warm nature; it enters lung, liver and kidney meridians; has the effects of expelling wind and removing dampness, dispelling cold and relieving pain, promoting blood circulation and removing obstruction in channels, and eliminating phlegm and relieving cough; it can be used for treating rheumatic arthralgia, stomach cold pain, traumatic injury, cough, and excessive phlegm. Caulis et folium Periplocae Forrestii is root or whole plant of Strychnos angustifolia Gardneria angustifolia wall of Loganiaceae; bitter taste, cool nature and little toxicity; has effects in expelling pathogenic wind, removing dampness, promoting blood circulation, expelling collateral obstruction, relieving arthralgia, and relieving pain; can be used for treating rheumatic arthritis, traumatic injury, gastralgia, dyspepsia, amenorrhea, and dysentery. The Alangium platanifolium is lateral root, fibrous root (fibrous root) or leaf, flower of Alangium chinense (Lour.) Harms and Guachua A.platanifolium (Sieb. et Zucc) Harms of Alangium platanifolium of Alangicaceae; warm in nature, pungent and bitter in flavor; it enters liver, kidney and heart meridians; has the effects of dispelling pathogenic wind, removing dampness, relieving rigidity of muscles, activating collaterals, dispelling blood stasis and relieving pain; it is commonly used for arthralgia due to wind-dampness, numbness of limbs, and traumatic injury. Caulis Sargentodoxae is dry rattan of Sargentodoxa cuneata (Oliv.) Rehd. et Wils.) belonging to Lardizabalaceae; harvesting in autumn and winter, removing lateral branches, cutting, and drying; bitter taste and mild nature; entering large intestine and liver meridian; has the functions of clearing away heat and toxic materialsPromoting blood circulation, dispelling pathogenic wind and relieving pain; can be used for treating abdominal pain due to intestinal abscess, pyocutaneous disease due to heat toxin, amenorrhea, dysmenorrhea, traumatic injury, swelling and pain, and rheumatalgia. The Hemisalantas arum is rhizome or stem of Alocasiacrrhizorrhiza (L.) Schott of Araceae; pungent taste and cold nature; the channels of heart, liver, gallbladder and large intestine; has the effects of clearing away heat and toxic materials, promoting qi circulation, relieving pain, eliminating stagnation, and relieving swelling; it is commonly used for treating influenza, common cold, abdominal pain, pulmonary tuberculosis, rheumatic osteodynia, furuncle, carbuncle, cellulitis, scrofula, carbuncle, alopecia areata, scabies, insect and snake bite. Radix Aconiti Brachypodi isRanunculaceae familyRoot tuber of Aconitum brachypodum Diels of Aconitum; digging roots at the end of autumn, removing soil, and drying in the sun; bitter and pungent taste; warm nature with strong toxicity; has effects in dispelling pathogenic wind and removing dampness, promoting blood circulation, and relieving pain; can be used for treating traumatic injury, rheumatalgia, toothache, fracture, sprain, pyocutaneous disease, and toxic swelling. Radix Aconiti is prepared from radix AconitiButtercup (Ranunculus japonicus)Dried mother root of Aconitum carmichaelii Debx; digging in the late 6 th to the early 8 th of the month, removing the rootlets, fibrous roots and silt, and drying in the sun; pungent and bitter in flavor; fever with great toxicity; heart, liver, kidney, spleen meridians; has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain; can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, and anesthesia and pain relieving. The rhizoma arisaematis is dry blocky lotus of rhizoma arisaematis AWsaema erubecens (Wall.) Schott, Arfsaema arumene Maxim, or Arfsaema amurense Maxim; digging in autumn and winter when stem and leaf withered, removing fibrous root and outer skin, and drying; bitter and pungent taste; warm in nature, toxic; it enters lung, liver and spleen meridians; has the effects of resolving hard mass and relieving swelling; it is used externally to treat carbuncle, swelling, snake and insect bite. Toddalia asiatica is root of Toddalia asiatica Lam of Rutaceae; bitter and numb taste; warm in nature and with little toxicity; has effects in dispelling blood stasis, stopping bleeding, dispelling pathogenic wind, removing dampness, relieving swelling, and removing toxic materials; it can be used for treating common cold, wind cold, gastralgia, intercostal neuralgia, rheumatic osteodynia, traumatic injury, and hemoptysis. The herba Chelidonii is dried whole plant of Chelidonium majus L of Papaveraceae; collected in summer and autumn, silt is removed, and the mixture is dried in the shade or in the sun; bitter taste, cold nature, toxicity; spleen and lung meridian entered; has spasmolytic, analgesic, antitussive, and antiasthmatic effects; can be used for treating gastralgia, cough, asthma, and pertussis.
Square solution: miao nationality thinks that cancer pain is closely related to pain caused by the disease of the male tortoise, and is caused by excessive accumulation of four toxins, namely cold, heat, wind and dampness, which causes the body to benefit qi deficiency, and the body cannot effectively operate, regulate and control the toxin and discharge the toxin, so that the toxin is accumulated in the body, forms a mass for a long time to cause qualitative change, presses viscera channels and collaterals tissues, or excessively consumes body gas, blood and water to generate pain. The syndrome of the recipe is the pain caused by the accumulation of toxic materials in the body and the compression of viscera, meridians and tissues by the male tortoise. For the treatment, the main action is to expel "poison", and the actions of counteracting toxic pathogen and dissipating food stagnation, and relieving pain and qi are used. In the recipe, the ingredients of Chuan Wu, Kusnezoff monkshood root and radix aconiti brachypodi which are the main drugs of big poison are used to counteract poison with poison and warm meridians to relieve pain. Tou Gu Xiang, Hei Gu Teng, Chinese alangium, sargentgloryvine stem, Feilongzhao, Tian nan xing dispersing accumulation and relieving pain, and Hai Gu for removing qi and relieving pain, and the above herbs are mostly toxic, can remove the toxicity of cold, heat, wind and dampness, and can also assist the effect of strengthening the toxicity attacking effect of the collar herb, so as to be used as bottom-laying herbs (all thin and thick). Chelidonium majus has the actions of removing toxicity and alleviating pain, and cold in nature can produce pungent and hot herbs as a protective herb. The recipe combines three-in-one methods to achieve the effects of counteracting toxic pathogen, dissipating stagnation, expelling qi and alleviating pain.
The formula is an external preparation, is mostly insoluble in water, and can obtain an extracting solution by adopting an ethanol cold soaking method from the viewpoint of easy storage. The concentration of ethanol, the amount of ethanol, the extraction time and the extraction frequency all influence the extraction rate of the effective components, if the concentration of ethanol and the amount of ethanol are insufficient, the solvent can not soak the medicinal materials in the prescription, the effective components can not be completely extracted, and if the extraction time and the extraction frequency are insufficient, the medicinal materials can not be fully extracted, and the extraction rate of the medicinal materials is influenced. Too long extraction time and too many times will result in decomposition of the effective components. But also reduces the extraction rate of the medicinal materials. The inventor proves that the effective components of the medicinal materials can be basically dissolved out after 2-3 times of soaking.
Compared with the prior art, the traditional Chinese medicine composition selects the formula of kusnezoff monkshood root, Tou Guxiang, caulis periplocae, Chinese alangium, sargentgloryvine stem, alocasia odorata, short-pedicel aconite root, arisaema consanguineum schott, asiatic toddalia root and celandine, has the effects of dispelling cold and relieving pain, promoting blood circulation and removing obstruction in channels, dispelling wind and eliminating dampness, clearing heat and detoxicating, promoting qi circulation and relieving pain, and eliminating stagnation and reducing swelling, can control cancer pain, and is suitable for people suffering from cancer and accompanied with serious cancer pain.
The invention is further illustrated by the following examples, which are not to be construed as limiting the invention thereto.
The specific implementation mode is as follows:
example 1:
prescription: 30g of kusnezoff monkshood root, 60g of lysimachia christinae hance, 30g of periploca forrestii, 20g of Chinese alangium, 60g of sargentgloryvine stem, 30g of alocasia macrorrhiza, 10g of short-pedicel aconite root, 10g of rhizoma arisaematis, 30g of toddalia asiatica and 30g of celandine.
The process comprises the following steps: weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 1.5 times of 70% ethanol, soaking for 3 times, each time for 12 hours, collecting the leaching solution, standing for 24 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the tincture.
The usage and dosage are as follows: the preparation is applied to skin surface once in the morning and evening, 20ml each time, and is used together with crossbow needle to stimulate acupoints.
Example 2:
prescription: 10g of kusnezoff monkshood root, 20g of lysimachia christinae hance, 10g of periploca forrestii schltr, 5g of Chinese alangium, 20g of sargentgloryvine stem, 10g of alocasia macrorrhiza, 5g of short-pedicel aconite root, 10g of rhizoma arisaematis, 10g of toddalia asiatica and 10g of celandine.
Weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 2 times of 70% ethanol, soaking for 2 times, 24 hours each time, collecting the leaching solution, standing for 48 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the liniment.
The usage and dosage are as follows: the preparation is applied externally, 20ml each time in the morning and evening, is applied on flannelette or other soft materials, is lightly coated on affected parts, and is matched with crossbow medicine needles to stimulate acupuncture points.
Example 3:
prescription: 60g of kusnezoff monkshood root, 100g of Tou Guxiang, 60g of black bone vine, 50g of Chinese alangium, 100g of sargentgloryvine stem, 60g of alocasia macrorrhiza, 40g of short-pedicel aconite root, 60g of common arisaema root, 60g of asiatic toddalia root and 60g of celandine.
The process comprises the following steps: weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 1 time of 70% ethanol, soaking for 2 times, collecting the leaching solution each time 18 times, standing for 48 hours, filtering, adding ethanol with the original concentration to 1000ml from a filter, subpackaging in a pressure-resistant container, and installing a valve to obtain the spray.
The usage and dosage are as follows: the composition is applied topically, 20ml each time, in the morning and evening, sprayed on skin surface, and administered with crossbow needle to stimulate acupoints.
Example 4:
prescription: 60g of kusnezoff monkshood root, 100g of Tou Guxiang, 60g of black bone vine, 50g of Chinese alangium, 100g of sargentgloryvine stem, 60g of alocasia macrorrhiza, 40g of short-pedicel aconite root, 60g of common arisaema root, 60g of asiatic toddalia root and 60g of celandine.
The process comprises the following steps: weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 2 times of 70% ethanol, soaking for 2 times, 24 hours each time, collecting the leaching solution, standing for 48 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the tincture.
The usage and dosage are as follows: the preparation is applied to skin surface once in the morning and evening, 20ml each time, and is used together with crossbow needle to stimulate acupoints.
Example 5:
prescription: 50g of kusnezoff monkshood root, 40g of lysimachia christinae hance, 30g of periploca forrestii, 5g of Chinese alangium, 100g of sargentgloryvine stem, 20g of alocasia macrorrhiza, 40g of short-pedicel aconite root, 10g of common arisaema root, 50g of asiatic toddalia root and 60g of celandine.
Weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 1 time of 70% ethanol, soaking for 3 times, each time for 18 hours, collecting the leaching solution, standing for 24 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the liniment.
The usage and dosage are as follows: the preparation is applied externally, 20ml each time, in the morning and evening, and is applied to flannelette or other soft materials to be lightly coated on affected parts.
Example 6:
prescription: 10g of kusnezoff monkshood root, 80g of Tou Guxiang, 50g of caulis periplocae, 30g of Chinese alangium, 90g of sargentgloryvine stem, 30g of alocasia macrorrhiza, 2g of short-pedicel aconite root, 60g of common monkshood mother root, 10g of rhizoma arisaematis, 20g of toddalia asiatica and 30g of celandine.
The process comprises the following steps: weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 1 time of 70% ethanol, soaking for 2 times, collecting the leaching solution each time 18 times, standing for 48 hours, filtering, adding ethanol with the original concentration to 1000ml from a filter, subpackaging in a pressure-resistant container, and installing a valve to obtain the spray.
The usage and dosage are as follows: the composition is applied topically, 20ml each time, in the morning and evening, sprayed on skin surface, and administered with crossbow needle to stimulate acupoints.
The invention has carried out a large number of experimental studies, the following is the experimental study result of the invention:
experimental example 1 toxicity test
1 experimental animal: healthy, intact-skin New Zealand white rabbits, weighing 2.0-3.0kg, were provided by the Experimental animals center of Guizhou medical university, and the use licenses for the experimental animals were: SYXK (Qian) 2014-001. Ambient temperature: 18-23 ℃, humidity: 40% -60%, and feeding conditions are as follows: and (5) feeding in a single cage.
2, sample treatment: the tincture of the invention is mixed according to the low, medium and high dosages of the embodiment 1, and then is mixed with a proper amount of warm water for standby.
3, test method: after 3 days of quarantine, 12 healthy, adult, skin-intact New Zealand white rabbits were selected, and 4 animals were used for each group. The test animals were depilated 24h before the test, on both sides of the spinal column, without damaging the epidermis, with a depilating range of 3cm by 3cm each. The low, medium and high doses of the drug of the invention in example 1 were applied to the depilated skin on one side of the spine at an area of 2.5 x 2.5cm, respectively, and the other side was used as a control, applied once a day for 14 days. Shearing hair before each application from the second application, removing residual medicine with warm water, and observing the result after 1h, and simultaneously observing other toxic effects except irritation. Mean skin irritation response score (total score of erythema + total score of edema)/total number of animals. The average value of skin irritation reaction in the evaluation standard of skin irritation strength is 0-0.49 min, 0.50-2.99 min, 3.00-5.99 min and 6.00-8.00 min, which respectively represent no irritation, slight irritation, moderate irritation and strong irritation.
4 results are shown in table 1, table 2, table 3.
Table 1 results of skin irritation test of low dose group of inventive drug example 1
Table 2 skin irritation test results for the dose groups of example 2 of the inventive drug
Table 3 results of skin irritation test of high dose group of inventive drug example 3
And 5, conclusion: the average value of the integral of the skin reaction of the medicament in the multiple skin irritation tests is 0 minute, and the medicament in the multiple skin irritation tests is nonirritating.
Experimental example 2 drug efficacy experiment
Experimental animals and materials equipment: 50 male SD rats with the body mass of 250-300 g; rat Walker256 breast cancer cell line. Treating the medicine: the medicine is prepared according to the low, medium and high doses in the example 1 respectively; positive control drug: morphine sulfate. The instrument is a radiation thermosensitive stimulator (developed by national center for optical engineering and engineering research at Zhejiang university), VonFrey cilium mechanical stimulator (Northcoast medical, USA).
2, establishing an animal model of bone cancer pain: injecting a certain amount of Walker256 breast cancer cell suspension into the abdominal cavity of an SD rat for cell culture, collecting a large amount of ascites after feeding for a period of time, centrifuging the ascites and collecting cells. The model is established with reference to the method of Medhurst et al. After the rats were anesthetized with the intraperitoneal injection of the drug, they were fixed on the operating table in the supine position. Shaving off hair at the tibia part of the left calf of a rat, cutting the skin after disinfection, separating the muscle, exposing the lower tibia, puncturing and punching by using a 20mL syringe needle, then slowly injecting Walker256 breast cancer cells collected after ascites centrifugation into a marrow cavity by using a micro syringe, quickly sealing the drilled hole by using bone wax after injection, disinfecting the wound by using 75% alcohol, and suturing the wound layer by layer. The rats were observed for general conditions, feeding, weight, mobility and local changes in the tibia after surgery and were used for 5 days.
3 animal model grouping and dosing: a total of 50 rats were successfully prepared as bone cancer pain models. All rat dorsal hairs were removed and after the rats had rested for 5 days they were randomly divided into 5 groups of 10 animals per group, the invention group (example 1 low, medium and high doses); morphine sulfate group; model control group. Model control group: after hair is removed from the back, a blank medical adhesive plaster with the same size as the cancer pain facial area is externally applied, and then 10ml/kg of 0.7 percent glacial acetic acid is injected into the abdominal cavity immediately; morphine sulfate group: injecting 20mg/kg morphine sulfate into the abdominal cavity, and then injecting 10ml/kg glacial acetic acid with the concentration of 0.7 percent into the abdominal cavity; the medicine group of the invention is: after hair is removed from the back, the medicine is externally applied, and is matched with a crossbow medicine needle to stimulate acupuncture points, and after administration is carried out for 30min, 10ml/kg of 0.7% glacial acetic acid is injected into the cavity. Detecting the mechanical paw withdrawal reflex threshold (MWT) of the rat 1h after the administration by a VonFrey method respectively 3, 7 and 10 days after modeling, and reflecting the mechanical hyperalgesia degree; thermal paw withdrawal latency (TWL) was measured by the Harg-reaves method, reflecting the extent of thermal hyperalgesia.
4 statistical methods: data of results are mean. + -. standard deviation
Statistical analysis was performed using the SPSS22.0 software, with dunnett's t test for pairwise comparisons and one-way anova for group comparisons.
5 results are shown in tables 4 and 5.
TABLE 4 Effect of various treatments on bone cancer pain model rat MWT
TABLE 5 Effect of various treatments on TWL in bone cancer pain model rats
The results show that: in the embodiment of the invention, the MWT of each group of rats is obviously increased, the TWL is obviously prolonged, and the medicine can effectively treat chronic pain caused by cancer.
Claims (9)
1. A medicament for controlling cancer pain, characterized by: the medicine is prepared from (by weight parts) radix Aconiti Kusnezoffii 10-60, caulis et folium Gaultheriae Yunnanensis 20-100, caulis et folium Periplocae Forrestii 10-60, Chinese Alangium 5-50, caulis Sargentodoxae 20-100, Henry steudnera 10-60, radix Aconiti Brachypodi 5-40, radix Aconiti 10-60, rhizoma arisaematis 10-60, radix Toddaliae Asiaticae 10-60, herba Chelidonii 10-60 and adjuvants.
2. A drug for controlling cancer pain as claimed in claim 1, wherein: the medicine is prepared from 20-40 parts by weight of radix aconiti kusnezoffii, 50-70 parts by weight of lysimachia christinae hance, 20-40 parts by weight of periploca forrestii, 10-30 parts by weight of alangium platanifolium, 50-70 parts by weight of sargentgloryvine stem, 20-40 parts by weight of alocasia cucullata, 5-15 parts by weight of short-pedicel aconite root, 20-40 parts by weight of radix aconiti, 10 parts by weight of rhizoma arisaematis, 20-40 parts by weight of toddalia asiatica, 20-40 parts by weight of greater celandine and auxiliary materials.
3. A cancer pain management pharmaceutical solution as claimed in claim 1, wherein: the medicine is prepared from 30 parts by weight of radix aconiti agrestis, 60 parts by weight of caulis perllae, 30 parts by weight of caulis periplocae, 20 parts by weight of alangium chinense, 60 parts by weight of sargentgloryvine stem, 30 parts by weight of alocasia odorata, 10 parts by weight of short-pedicel aconite root, 30 parts by weight of radix aconiti, 10 parts by weight of rhizoma arisaematis, 30 parts by weight of asiatic toddalia root, 30 parts by weight of celandine and auxiliary materials.
4. A method for producing a cancer pain control drug as described in claims 1 to 3, characterized in that: all the medicinal materials in the prescription are weighed according to the proportion, combined with the medicinal auxiliary materials acceptable in the medicaments, processed according to the conventional preparation method and prepared into the corresponding medicinal preparation.
5. The method for producing a cancer pain control agent according to claim 4, wherein: weighing the medicinal materials according to a formula proportion, crushing into coarse powder, adding ethanol with a proper concentration, soaking for 2 times, collecting the leaching solution, standing, filtering, combining the filtrate with medicinal auxiliary materials acceptable in the medicaments, processing according to a conventional preparation method, and preparing into corresponding medicinal preparations.
6. The process for producing a cancer pain control agent according to claim 5, wherein: the medicinal preparation comprises tincture, liniment and spray.
7. The process for producing a cancer pain control agent according to claim 6, wherein: the tincture is prepared by the following steps: weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 1.5 times of 70% ethanol, soaking for 3 times, each time for 12 hours, collecting the leaching solution, standing for 24 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the traditional Chinese medicine composition.
8. The process for producing a cancer pain control agent according to claim 6, wherein: the liniment is prepared by: weighing the medicinal materials according to the formula proportion, crushing into coarse powder, adding 2 times of 70% ethanol, soaking for 2 times, collecting the leaching solution 24 hours each time, standing for 48 hours, filtering, and adding ethanol with the original concentration to 1000ml from a filter to obtain the traditional Chinese medicine composition.
9. The process for producing a cancer pain control agent according to claim 6, wherein: the spray is prepared by the following steps: weighing the medicinal materials according to a formula proportion, crushing into coarse powder, adding 1 time of 70% ethanol, soaking for 2 times, collecting the leaching solution each time 18 hours, standing for 48 hours, filtering, adding ethanol with the original concentration to 1000ml from a filter, subpackaging in a pressure-resistant container, and installing a valve to obtain the traditional Chinese medicine composition.
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