CN111110785A

CN111110785A - Carbuncle block eliminating ointment for treating cancer pain and preparation method thereof

Info

Publication number: CN111110785A
Application number: CN201811298974.7A
Authority: CN
Inventors: 程志强; 宋兵虎; 张晨红; 王钰锟
Original assignee: Beijing Cancer Medical Research Institute Of China West Alliance General Partnership
Current assignee: Beijing Cancer Medical Research Institute Of China West Alliance General Partnership
Priority date: 2018-11-01
Filing date: 2018-11-01
Publication date: 2020-05-08

Abstract

The invention relates to a carbuncle block eliminating ointment for treating cancer pain and a preparation method thereof, and the carbuncle block eliminating ointment comprises 5-15 parts of frankincense, 5-15 parts of myrrh, 5-15 parts of peach kernel, 5-15 parts of aconitum szechuan lovage rhizome, 5-15 parts of angelica dahurica, 5-15 parts of clematis root, 5-15 parts of fennel, 5-15 parts of costustoot, 5-15 parts of edible tulip, 5-15 parts of scorpion, 5-15 parts of rhizoma corydalis, 5-15 parts of notopterygium root and 5-15 parts of ligusticum chuanxiong hort. The preparation method comprises pulverizing the raw materials, decocting, and performing anaerobic fermentation. The carbuncle block eliminating ointment is externally applied by adopting the theory of traditional Chinese medicine dialectical treatment, can effectively treat cancer pain, has the effective rate of 91.57 percent, has obvious effect superior to non-opioid analgesics and opioid analgesics, and does not cause patients to have dependence and addiction.

Description

Carbuncle block eliminating ointment for treating cancer pain and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to carbuncle block eliminating paste for treating cancer pain and a preparation method thereof.

Background

Cancer pain generally refers to pain directly caused by tumors, wherein the tumors invade or press nerve roots, nerve trunks, nerve plexuses or nerves, invade brain and spinal cords, invade periosteum or bones, invade parenchymal organs and hollow organs, invade or block vascular systems, cause local necrosis, ulcer, inflammation and the like due to the tumors, and can cause serious pain under the conditions.

The present invention relates to a method for treating cancer pain, which is characterized by that the cancer pain is divided into medicine treatment and surgical treatment, and said method is characterized by that the medicine treatment is mainly used for treating cancer pain, and the operation treatment is combined with general physical condition of patient and survival time, and the current treatment method mainly adopts pain-relieving and symptom-improving treatment, and adopts "three-step therapy" clinically, ① first-step non-opioid analgesic is used for patient with mild cancer pain, and its main medicines are aspirin, acetaminophen (paracetamol), etc. and its auxiliary medicines can be used according to requirements.

Disclosure of Invention

In view of the above, the purpose of the present invention is to overcome the defects of the prior art, and to provide a carbuncle block eliminating ointment for treating cancer pain and a preparation method thereof, the carbuncle block eliminating ointment is applied externally by using the theory of traditional Chinese medicine dialectical treatment, can effectively treat cancer pain, has a treatment effective rate of 91.57%, has an effect obviously superior to that of non-opioid analgesics and opioid analgesics, and does not cause patients to have dependence and addiction.

In order to achieve the purpose, the invention adopts the following technical scheme:

a carbuncle block eliminating ointment for treating cancer pain comprises the following raw materials in parts by weight:

5-15 parts of frankincense, 5-15 parts of myrrh, 5-15 parts of peach kernel, 5-15 parts of aconitum chinese wolf, 5-15 parts of angelica dahurica, 5-15 parts of clematis root, 5-15 parts of fennel, 5-15 parts of costus root, 5-15 parts of edible tulip, 5-15 parts of scorpion, 5-15 parts of rhizoma corydalis, 5-15 parts of notopterygium root and 5-15 parts of ligusticum chuanxiong hort.

Preferably: a carbuncle block eliminating ointment for treating cancer pain comprises the following raw materials in parts by weight:

10 parts of frankincense, 10 parts of myrrh, 10 parts of peach kernel, 10 parts of aconitum chuanxiong, 10 parts of angelica dahurica, 10 parts of radix clematidis, 10 parts of fennel, 10 parts of elecampane, 10 parts of Indian iphigenia bulb, 10 parts of scorpion, 10 parts of rhizoma corydalis, 10 parts of notopterygium root and 10 parts of ligusticum chuanxiong hort.

Preferably: the preparation method of the aconitum chuanxiong hort comprises the following steps: soaking fresh radix Aconiti in cold water, rinsing with water for 2-3 times per day until the radix Aconiti is slightly spicy, decocting together with Glycyrrhrizae radix and semen Sojae Atricolor in water until there is no white core in radix Aconiti, removing Glycyrrhrizae radix and semen Sojae Atricolor, air drying, moistening, slicing, and sun drying.

Further: the weight ratio of the radix aconiti, the liquorice and the black beans is 20:1: 2.

Further: the water content of the slices is 5-10 wt%.

The toxicity of the raw radix aconiti is extremely strong, which is not only related to variety and collection time, but also related to processing, decoction and the like, the toxicity of the radix aconiti obtained by different processing techniques is very different, the alkaloid content can be lost by 81.3 percent in the processing process, the toxicity of the aconite in different areas can be measured by more than 8 times, if the radix aconiti is not processed properly, a user can be poisoned, and the poisoning amount can cause the canine tachycardia, the ventricular fibrillation and the flutter; the toxicity of animals with fatigue, hemorrhage and hunger can be reduced, and those with hyperactive sympathetic nervous system are susceptible to poisoning.

A method for preparing the carbuncle block eliminating ointment comprises the following steps:

(1) respectively cleaning the frankincense, the myrrh, the peach kernel, the angelica dahurica, the clematis root, the fennel, the costustoot, the edible tulip, the scorpion, the rhizoma corydalis, the notopterygium root and the ligusticum chuanxiong hort, drying the cleaned substances until the water content is 5 to 10 percent, and then mixing the dried substances to obtain a mixed material;

(2) adding the aconitum chuanxiong hort into the mixed material and crushing to obtain mixed powder;

(3) adding water into the mixed powder for decocting until the water content is not more than 20 wt% to obtain paste;

(4) and carrying out anaerobic fermentation on the paste at normal temperature for 2-4 months to obtain the carbuncle block eliminating ointment.

Preferably: the particle fineness of the mixed powder in the step (2) is not less than 200 meshes.

Preferably: in the step (3), the boiling is carried out by heating to boiling with big fire and then decocting with small fire at 50-60 ℃.

Olibanum, also known as Lavender, horsetail, Nipple incense, Tu Xiang, Tian ze Xiang and Mole incense, is a resin exuded from the bark of Boswellia carterii Birdw of Boswellia carterii of Burseraceae and Boswellia bhauradaijiana Birdw of the same genus. The frankincense is warm in nature and pungent and bitter in taste, is used for regulating qi and activating blood, relieving pain, dispelling toxin, treating stagnation of qi and blood, heart and abdomen pain, carbuncle sore and pyogenic infections, traumatic injury, dysmenorrheal and postpartum blood stasis and stabbing pain, has a remarkable analgesic effect, and the uterus pill taking the frankincense as the first medicine has stronger bacteriostatic action than various antibiotics and can effectively kill trichomonas.

Myrrha is gum resin of Commiphora myrrha Engl or Commiphora fortunei of Burseraceae, also called powder medicine (compendium), Myrrha, etc. Can be used for treating blood stasis and pain in chest and abdomen, dysmenorrhea, amenorrhea, abdominal mass, traumatic injury, carbuncle, skin ulcer, intestinal carbuncle, conjunctival congestion, and swelling and pain. Has the effects of promoting blood circulation, relieving pain, eliminating swelling, promoting granulation, and removing blood stasis.

Aconitum carmichaeli (Aconitum carmichaeli Debx) also named as Aconitum carmichaeli, Saxiyu, Yizi, Jidu, Dugong, Gunn, Aconitum carmichaeli, etc., and has the following properties: pungent taste; bitter; heating; with strong toxicity, it can dispel wind, remove dampness, warm meridians, dispel cold and alleviate pain. It can be used for treating arthralgia due to wind-cold-dampness, arthralgia, numbness of limbs, hemiplegia, headache due to wind-cold evil, psychroalgia of heart and abdomen, cold hernia pain, traumatic injury, blood stasis, cellulitis, and toxic swelling, and can be used for relieving pain due to anesthesia.

Clematis chinensis, also named Bailian Geng, Lepidium Sativum, Tiepi Manshurica, Tiepi Clematidis, Tiepi Clematis chinensis, etc., is the dried root and rhizome of Clematis chinensis Osbeck, Clematis gossypii caulis clematidis Clematishexetala pall or Clematis manshurica Rupr. Has effects of dispelling pathogenic wind, removing dampness, dredging collaterals and relieving pain. Can be used for treating rheumatic arthralgia, numbness of limbs, spasm of muscles and tendons, difficulty in flexion and extension, choking throat, etc.

Fennel, also known as Huaixiang, Huaixiang seed, herba Coriandri, Fennel seed, and rice fragrance, has the effects of stimulating appetite, regulating qi-flowing, dispelling cold, and tonifying yang. Mainly, the middle jiao has cold, anorexia, nausea and emesis, abdominal psychroalgia, hernia pain, and testis swelling and pain; qi stagnation of the spleen and stomach, abdominal distention and pain. Recorded in Ben Cao Hui Yan (materia Medica) that Feng Hui is a middle-jiao-warming and qi-quickening medicine; in Tang materia Medica, it is also recorded that "Fennel is an important product for warming middle-jiao to dispel cold and building up tea". Fennel preparations carried in Chinese dictionary are commonly used as stomachic, cold-dispelling, qi-moving and pain-relieving herbs. The anethole can promote the maturation of bone marrow cells and release the bone marrow cells into peripheral blood, has obvious effect of increasing leucocytes, mainly increases neutrophils, and can be used for leukopenia.

Radix Aucklandiae (Radix Aucklandiae) is a generic name of saussurea lappa Clarke and Radix Aucklandiae of Compositae. Also called costus root, honey incense, birthwort root, five-costus root and south costus root, which belong to saussurea of Compositae and are mainly used for treating pathogenic factors, pestilence and pestilence, strengthening will, treating stranguria mainly, and improving the sleep after long-term taking (Ben Jing). Disinfecting, killing ghost essence, warm malaria, poison, qi deficiency, cold in the muscle, and inducing essence of the drug (entry). It is used to treat heart and abdomen qi stagnation, bladder psychroalgia, vomiting, regurgitation, cholera, diarrhea, dysentery, spleen invigorating, digestion promoting, and miscarriage preventing. Nine kinds of heartache, cold wind in long-term, lump and swelling pain due to addiction, upward choking, vexation, weakness, blood and qi prickling, intolerable pain and drunk after drinking (right to screen). Disperse stagnation of qi, regulate qi, harmonize stomach qi, and purge lung qi (elements). Moving liver meridian qi, stewing and strengthening large intestine (Zhanheng). For thoroughfare vessel disease, adverse qi and urgency, and constipation due to retention of urine.

Pseudobulbus Cremastrae Seu pleiones, name of Chinese medicine. Is dried pseudobulb of Rhododendron simsii planch, Pleiones bulbifera or Pleiones yunnanensis of Orchidaceae. The former is commonly called "pleione", the latter two are commonly called "iceball", and the other names are calyx Seu fructus Physalis, Cornus Arundinis, herba Pyrolae, and nonsense herba etc. Collected in summer and autumn. Pseudobulbus Cremastrae Seu pleiones is sweet and slightly pungent in flavor, and is cool in nature. Has the effects of clearing away heat and toxic materials, eliminating carbuncle, and resolving hard mass, and can be used for treating carbuncle, furuncle, scrofula, subcutaneous nodule, snake and insect bite, and limping.

Scorpio, named as Chinese medicine, also named as Buthus martensii Karsch, Scorpio, and Poria. Is dried body of Buthus martensii Karsch, an animal belonging to family Buthidae. Catching in spring to autumn, removing silt, decocting in boiling water or boiling saline water until the whole body is stiff, taking out, placing in ventilated place, and drying in shade. It is used to extinguish wind, relieve spasm, counteract toxic pathogen, dissipate nodulation, dredge collaterals and alleviate pain. Can be used for treating infantile convulsion, spasm, facial distortion due to apoplexy, hemiplegia, tetanus, rheumatism, headache, pyocutaneous disease, and lymphoid tuberculosis.

Rhizoma corydalis and corydalis are also named as corydalis tuber and corydalis tuber, which are perennial herb plants of corydalis of Papaveraceae, and rhizoma corydalis is recorded in Kai Bao Ben Cao, has warm property and pungent and bitter taste, enters heart, spleen, liver and lung, is a wonderful product for activating blood circulation to dissipate blood stasis, promoting qi circulation and relieving pain, and is known to have the effect of relieving pain. Li Shizhen induces that rhizoma corydalis has four main effects of promoting blood circulation, regulating qi, relieving pain and removing urine in Ben Cao gang mu, and Chong rhizoma corydalis is specially used for treating pain in upper and lower parts of the whole body because it can promote qi stagnation in blood and qi stagnation in blood.

Notopterygium incisum Ting ex H.T. Chang is a perennial herb of Notopterygium of Umbelliferae, Notopterygium, Qiangqing, Qianghuqin, Huwang Qushizi, Qiangshu, Evodia and Hei Yao, the rhizome and root of the drug are warm in nature and can dispel cold-dampness, and the drug is used for treating exogenous wind-cold, headache without sweat, arthralgia due to cold-dampness and pain of upper limbs due to wind-dampness.

The rhizoma Ligustici Chuanxiong is named as Dachuanxiong rhizome, Cuo Xiong, and wine rhizoma Ligustici Chuanxiong. Chuan Xiong is indicated for pain due to blood stasis and qi stagnation. Pungent and warm in property, with the actions of activating blood and resolving stasis, and moving qi and relieving pain, it is a qi-flowing herb in blood, and has the action of activating qi and blood, so it is indicated for various pains in chest, hypochondrium and abdomen due to qi stagnation and blood stasis. Has effects in promoting blood circulation and regulating menstruation, and can be used for treating various gynecological diseases. For instance, it is indicated for amenorrhea due to blood stasis and dysmenorrhea.

The invention has the beneficial effects that:

(1) the carbuncle block eliminating ointment is prepared from 13 Chinese herbal medicines, and by applying the theory of dialectical treatment of the traditional Chinese medicine, the aim of treating cancer pain is finally achieved by starting from regulating qi and activating blood circulation and assisting with the drug effects of clearing away heat and toxic materials, dispelling wind and cold, tonifying deficiency and warming yang, wherein the frankincense has the effects of regulating qi and activating blood, relieving pain, reducing swelling and promoting tissue regeneration; myrrh has the functions of dissipating blood stasis and relieving pain, and eliminating swelling and promoting granulation, and the myrrh is used as an essential medicine for dredging viscera and meridians, has the functions of promoting qi circulation and blood circulation, and is also good at treating wind-cold-dampness arthralgia, numbness of the whole body, limb paralysis, swelling and pain of all sores and ulcers or sore hardness and no pain of all sores; in addition, radix Angelicae Dahuricae is used for dispelling pathogenic wind, removing dampness, inducing resuscitation, relieving pain, relieving swelling, and expelling pus; the clematis root has the effects of dispelling wind and removing dampness, and dredging collaterals and relieving pain; scorpio has effects of calming endogenous wind, relieving spasm, removing toxic substance, resolving hard mass, dredging collaterals, and relieving pain; rhizoma corydalis has effects of promoting blood circulation, removing blood stasis, regulating qi-flowing and relieving pain; notopterygii rhizoma has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, removing dampness, and relieving pain; the ligusticum wallichii is capable of activating blood and qi, dispelling wind and relieving pain; peach kernel is further added to activate blood and eliminate phlegm, resist inflammation and relieve pain; radix Aconiti Kusnezoffii has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain; fennel for dispelling cold, relieving pain, regulating qi and harmonizing stomach; the costustoot has the effects of promoting qi circulation, relieving pain, strengthening spleen and promoting digestion; the edible tulip can clear away heat and toxic materials, reduce phlegm and dissipate stagnation;

the invention adopts 13 Chinese herbal medicines to prepare the external ointment according to the formula, can detoxify, detumescence, promote granulation and relieve pain by applying sores and ulcers, achieves the aim of treating cancer pain, is a product which is open, does not consume qi and blood, is the external ointment, is convenient for long-term use, and can reduce dependence and addiction. The invention is suitable for various cancer pains, such as lung cancer, liver cancer, pancreatic cancer, esophagus cancer, stomach cancer, pancreatic cancer and the like, and in the clinical application process, 178 cases of cancer pains are treated, wherein the effective rate of treatment is 91.57%, and the effect is obviously superior to that of non-opioid analgesics and opioid analgesics;

(2) the invention grinds each raw material into powder, and adds water to carry out anaerobic fermentation for 2-4 months, utilizes a microecology and bionics method, simulates the intestinal environment of a human body and the digestion and decomposition process of traditional Chinese medicine components in the human body in vitro by a biological grafting mode, carries out biological transformation on the extracted traditional Chinese medicine effective components, converts macromolecular substances of the traditional Chinese medicine into small molecular components which can be directly absorbed by the intestinal tract of the human body by microorganisms, 13 kinds of Chinese herbal medicines which are predigested and transformed not only completely eliminate the harmful toxicity of each medicine, but also the formed paste has quantitative curative effect and can be quickly absorbed by the human body, the drug effect is improved by 4-28 times compared with the traditional Chinese medicine, wherein the effective components in the medicinal materials can be completely extracted by small fire decoction and anaerobic fermentation in sequence under the conditions of temperature, time and the like, thereby solving the problems of slow treatment effect and inaccurate treatment effect of the medicine prepared by adopting the same raw materials.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Example 1

5 parts of frankincense, 15 parts of myrrh, 5 parts of peach kernel, 15 parts of aconitum chuanxiong, 5 parts of angelica dahurica, 15 parts of radix clematidis, 5 parts of fennel, 15 parts of elecampane, 5 parts of Indian iphigenia bulb, 15 parts of scorpion, 5 parts of rhizoma corydalis, 15 parts of notopterygium root and 5 parts of ligusticum chuanxiong hort.

The preparation method of the carbuncle block eliminating ointment comprises the following steps:

(1) preparing monkshood root: soaking and bleaching fresh radix Aconiti with cold water, changing water for 2 times every day, taking out when the radix Aconiti is nearly tasted slightly spicy, decocting together with Glycyrrhrizae radix and semen Sojae Atricolor at a weight ratio of 20:1:2 with water until there is no white core in the radix Aconiti, removing Glycyrrhrizae radix and semen Sojae Atricolor, air drying, moistening until the water content is 5 wt%, and slicing to obtain the final product;

(2) crushing the traditional Chinese medicines: respectively cleaning the frankincense, the myrrh, the peach kernel, the angelica dahurica, the radix clematidis, the fennel, the elecampane, the edible tulip, the scorpion, the rhizoma corydalis, the notopterygium root and the ligusticum chuanxiong hort, drying the cleaned substances until the water content is 5 percent under the sterile and dustless conditions, mixing the substances to obtain a mixed material, adding the aconitum chuanxiong hort into the mixed material, and crushing the mixed material to obtain mixed powder with the particle fineness of 200 meshes; the mixed materials are crushed by adopting an ultramicro crushing technology and are subjected to ultrasonic crushing, so that the central particle size of the crude drug is below 10 microns and is optimally lower than 6 microns, the cell wall breaking rate is over 95 percent, the active ingredients in the crude drug are directly exposed, and the dissolution and the effect taking of the components of the crude drug are more rapid and complete;

(3) boiling: adding water into the mixed powder, heating to boil (100 ℃) by big fire, and then decocting by small fire at 50 ℃ until the water content is 20 wt% to obtain paste;

(4) preparing paste: and (3) carrying out anaerobic fermentation on the paste at normal temperature for 2 months to obtain the carbuncle block eliminating paste which can be in a block shape.

Alternatively, the boiling and paste preparation processes can be replaced by the following modes:

embedding: the nanometer jet atomizer is adopted for five-stage atomization, the mixed powder is embedded and dried into a plurality of nanometer microcapsule powder at normal temperature, the particle size of each nanometer microcapsule powder is 20-80 nanometers, and the better particle size is 20-40 nanometers, so that the active ingredients of the medicine can be prevented from volatilizing, the active ingredients are easily and directly absorbed by the skin of a human body, the active substances can play a role, the bioavailability of the medicine is improved, and the medicine effect is improved.

When in use, 9-degree white vinegar is added into the microcapsule powder, water is properly added according to the requirement for decoction, and the mixture is prepared into paste with the water content of 20 percent.

Example 2

(1) preparing monkshood root: soaking and bleaching fresh radix Aconiti with cold water, changing water 3 times daily, taking out when the radix Aconiti is slightly spicy, decocting together with Glycyrrhrizae radix and semen Sojae Atricolor at a weight ratio of 20:1:2 with water until there is no white core in radix Aconiti, removing Glycyrrhrizae radix and semen Sojae Atricolor, air drying, moistening until the water content is 8 wt%, and slicing to obtain the final product;

(2) crushing the traditional Chinese medicines: respectively cleaning the frankincense, the myrrh, the peach kernel, the angelica dahurica, the clematis root, the fennel, the costustoot, the edible tulip, the scorpion, the rhizoma corydalis, the notopterygium root and the ligusticum chuanxiong hort, drying until the water content is 8%, then mixing to obtain a mixed material, adding the aconitum chuanxiong hort into the mixed material, and crushing to obtain mixed powder with the particle fineness of 300 meshes;

(3) boiling: adding water into the mixed powder, heating to boil with big fire, and decocting with small fire at 55 ℃ until the water content is 18 wt% to obtain paste;

(4) and (3) carrying out anaerobic fermentation on the paste at the normal temperature for 3 months to obtain the carbuncle block eliminating paste.

embedding: the nanometer jet atomizer is adopted for five-stage atomization, the mixed powder is embedded and dried into a plurality of nanometer microcapsule powder at normal temperature, and the particle size of each nanometer microcapsule powder is 20-60 nanometers, so that the active ingredients of the medicine can be prevented from volatilizing and can be directly absorbed by the skin of a human body easily, the active substances can play a role, the bioavailability of the medicine is improved, and the medicine effect is improved.

Example 3

15 parts of frankincense, 5 parts of myrrh, 15 parts of peach kernel, 5 parts of aconitum chuanxiong, 15 parts of angelica dahurica, 5 parts of radix clematidis, 15 parts of fennel, 5 parts of elecampane, 15 parts of edible tulip, 5 parts of scorpion, 15 parts of rhizoma corydalis, 5 parts of notopterygium root and 15 parts of ligusticum chuanxiong.

(1) preparing monkshood root: soaking and bleaching fresh radix Aconiti with cold water, changing water 3 times daily, taking out when the radix Aconiti is slightly spicy, decocting together with Glycyrrhrizae radix and semen Sojae Atricolor at a weight ratio of 20:1:2 with water until there is no white core in radix Aconiti, removing Glycyrrhrizae radix and semen Sojae Atricolor, air drying, moistening to water content of 10 wt%, and slicing to obtain the final product;

(2) crushing the traditional Chinese medicines: respectively cleaning the frankincense, the myrrh, the peach kernel, the angelica dahurica, the clematis root, the fennel, the costustoot, the edible tulip, the scorpion, the rhizoma corydalis, the notopterygium root and the ligusticum chuanxiong hort, drying until the water content is 10%, mixing to obtain a mixed material, adding the aconitum chuanxiong hort into the mixed material, and crushing to obtain mixed powder with the particle fineness of 200 meshes;

(3) boiling: adding water into the mixed powder, heating to boil with big fire, and decocting with small fire at 60 deg.C until the water content is 20 wt% to obtain paste;

(4) and (3) carrying out anaerobic fermentation on the paste at the normal temperature for 4 months to obtain the carbuncle block eliminating paste.

embedding: the nanometer jet atomizer is adopted for five-stage atomization, the mixed powder is embedded and dried into a plurality of nanometer microcapsule powder at normal temperature, and the particle size of each nanometer microcapsule powder is 20-30 nanometers, so that the active ingredients of the medicine can be prevented from volatilizing and can be directly absorbed by the skin of a human body easily, the active substances can play a role, the bioavailability of the medicine is improved, and the medicine effect is improved.

The application method of the invention is that the carbuncle block eliminating ointment is directly put on the affected part, the standing time is not limited, and the comfort of the patient is taken as the degree until the cancer pain is relieved and the disease condition is improved.

The following description will further illustrate the beneficial effects of the external application medicine of the present invention through clinical case statistics using the carbuncle block eliminating ointment obtained in example 2.

The clinical cases of the disease comprise 178 cases, each half of men and women, the age is 50-75 years, the average age is 58 years, and the cases comprise lung cancer, liver cancer, pancreatic cancer, esophageal cancer, gastric cancer and pancreatic cancer.

1. Cancer pain observation

(1) Assessment of pain

No pain 0, severe pain 100;

(2) intensity of pain

0-no pain; 1-mild discomfort; 2-discomfort; 3-difficulty in handling; 4-feared pain; 5-extreme pain;

2. criteria for therapeutic effect

The effect is shown: the pain integral value after treatment is reduced by more than or equal to 70 percent compared with the integral value before treatment.

The method has the following advantages: the pain integral value after treatment is reduced by more than or equal to 30 percent and less than 70 percent compared with the integral value before treatment.

And (4) invalidation: the post-treatment pain integrated value was < 30% lower than the pre-treatment integrated value.

Note: calculation formula (nimodipine method): [ (integration before treatment-integration after treatment) ÷ integration before treatment ] × 100%.

3. Therapeutic results

The carbuncle block eliminating ointment is used for treating 178 cancer pains, wherein 92 cases of obvious effects, 71 cases of effects and 15 cases of no effects have the total effective rate of 91.57%, and the treated effective patients are all called that the carbuncle block eliminating ointment can relieve pain within 30 minutes of medication, dependence and addiction of other commonly taken analgesics such as non-opioid analgesics or opioid analgesics are avoided, and the pain effect is obviously reduced after continuous use for 10-20 days.

Example of the medical record 1

Zhangqi, male, age 71, retirement worker. The initial diagnosis in 5 months and 20 days in 2013 mainly comprises the following complaints: the liver was found to be blocked for more than 1 month. The patient feels the feeling of abdominal fullness before 1 month, the liver area is dull and painful, and the body weight is gradually reduced with asthenia. The history of hepatitis is 13 years. Prompting abdominal ultrasound and CT examination: nodules of 5cm multiplied by 5cm and 3cm multiplied by 3cm are seen in the right liver lobe, moderate cirrhosis, and positive detection of alpha-fetoprotein. Then, the tissue biopsy is carried out under the ultrasonic guidance of a central hospital in Jinan City, and the primary liver cancer is confirmed by the examination of pathological sections. Patients refused surgery and were treated conservatively. The symptoms are sallow complexion, paroxysmal dull pain in the liver area, stuffiness and hardness in the epigastrium, abdominal distension and no appetite, listlessness and dry stool. A deep-red tongue with no coating and a thready, wiry and rapid pulse. The traditional Chinese medicine diagnosis is as follows: the pattern of liver fullness is due to qi stagnation and blood stasis. The medicine is placed on a pain part for 2-4 hours every day, the pain is relieved after continuous treatment for 15 days, and the patient is subjected to a repeated diagnosis after 1 month, so that the pain can be tolerated during the use period, and the appetite is improved.

Example of the medical record 2

Liu Zhi, female, 57 years old, 8 months and 4 days of initial diagnosis in 2012. The main complaints are: the abdominal pain is more than 3 months. The patient had abdominal pain and weight loss 3 months ago. The local hospital has performed gastrointestinal barium transudation, which prompts the patient to ascend colon cancer, refuses surgery and chemotherapy, and seeks traditional Chinese medicine conservative treatment. The symptoms include persistent abdominal pain, painful face, listlessness, anorexia, poor sleep, chest distress, short breath, loose stool, purulent blood, aversion to cold, cold limbs, pale red tongue, white greasy coating, deep, thready and intermittent pulse. Physical examination: the whole abdomen is flat and soft, the right abdomen is tenderness, the rebound pain is negative, and the percussion pain of the kidney and liver regions is negative. Traditional Chinese medicine diagnosis: abdominal pain (spleen and kidney deficiency, blood stasis obstructing collaterals). After the medicine is continuously used for 15 days and 3-5 hours every day, the pain is relieved, and the abdominal pain disappears after 3 weeks of return diagnosis.

Cancer pain is a particular type of pain, a common symptom in patients with mid-to-late stage cancer, and the cause is directly related to malignancy. From the clinical point of view, the pathogenesis of cancer pain is characterized by deficiency and excess mixed, the deficiency is caused by healthy qi damage, the excess is qi stagnation, blood stasis and the like, and the treatment generally aims at strengthening healthy qi and eliminating evil to dredge and relieve pain. The traditional Chinese medicine has definite clinical curative effect on cancer pain, and plays a great role in relieving pain in a plurality of middle and late cancer patients. The traditional Chinese medicine has slow and lasting analgesic effect, has the advantages of no addiction, drug resistance, little toxic and side effect and the like, and greatly enriches the content of first and second gradient (non-morphine drugs) cancer pain treatment. Through a large number of clinical verifications, the invention can improve the life quality and the immunologic function of patients, has high safety and definite curative effect, and is worthy of popularization. The traditional advantages are obvious in clinical practice of treating cancer pain, and the development and application in the future also have wide prospects.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The carbuncle block eliminating ointment for treating cancer pain is characterized by comprising the following raw materials in parts by weight:

2. The carbuncle block eliminating ointment of claim 1, which is prepared from the following raw materials in parts by weight:

3. The carbuncle block eliminating ointment as claimed in claim 1 or 2, which is prepared from monkshood root by the following steps: soaking fresh radix Aconiti in cold water, rinsing with water for 2-3 times per day until the radix Aconiti is slightly spicy, decocting together with Glycyrrhrizae radix and semen Sojae Atricolor in water until there is no white core in radix Aconiti, removing Glycyrrhrizae radix and semen Sojae Atricolor, air drying, moistening, slicing, and sun drying.

4. The carbuncle block eliminating ointment of claim 3, wherein the weight ratio of the radix aconiti, the liquorice and the black beans is 20:1: 2.

5. The carbuncle block eliminating ointment of claim 3, wherein the water content of the slices is 5-10 wt%.

6. A method for preparing the carbuncle block eliminating ointment as claimed in any one of claims 1 to 5, which comprises the following steps:

(1) respectively cleaning the prepared frankincense, myrrh, peach kernel, aconitum chuanxiong, angelica dahurica, radix clematidis, fennel, elecampane, edible tulip, scorpion, rhizoma corydalis, notopterygium root and ligusticum chuanxiong hort according to the parts by weight, drying the cleaned products until the water content is 5 to 10 percent, and then mixing the products to obtain a mixed material;

(2) under the conditions of asepsis and dustless, the mixed material is subjected to ultrasonic crushing by adopting an ultramicro crushing technology, so that the central particle size of the crude drug is below 10 mu m, and the cell wall breaking rate reaches 95 percent, thereby obtaining mixed powder;

(3) carrying out five-stage atomization by adopting a nano jet atomizer, and embedding and drying at normal temperature to obtain nano microcapsule powder with the particle size of 20-80 nanometers;

(4) adding 9 degree white vinegar into the microcapsule powder, adding water, decocting, and concocting into paste with water content of 20%.

7. The method according to claim 6, wherein the step (4) is further followed by anaerobic fermentation of the paste at room temperature for 2-4 months to obtain a lump-shaped carbuncle mass eliminating ointment.

8. The production method according to claim 6, wherein the particle fineness of the mixed powder in the step (2) is not less than 200 mesh.

9. The preparation method according to claim 6, wherein the decocting in the step (4) is carried out by heating to boiling with strong fire and then decocting with slow fire at 50-60 ℃.

10. The method according to claim 6, wherein in the step (2), the particle diameter of the crude drug at the center is 5 to 6 μm.