CN111110775A

CN111110775A - A Chinese medicinal ointment for treating cancerous abdominal distention, and its preparation method

Info

Publication number: CN111110775A
Application number: CN201811298973.2A
Authority: CN
Inventors: 程志强; 宋兵虎; 张晨红; 王钰锟; 吴军凯; 张卫; 刘芳
Original assignee: Beijing Cancer Medical Research Institute Of China West Alliance General Partnership
Current assignee: Beijing Cancer Medical Research Institute Of China West Alliance General Partnership
Priority date: 2018-11-01
Filing date: 2018-11-01
Publication date: 2020-05-08

Abstract

The invention relates to a swelling eliminating paste for treating cancerous abdominal distension and a preparation method thereof, and the swelling eliminating paste is prepared from the following components in parts by weight: 10-20 parts of scorched areca nut, 5-15 parts of magnolia officinalis, 10-20 parts of fried radish seed, 5-15 parts of halite, 5-15 parts of fennel, 5-15 parts of elecampane, 5-15 parts of rhizoma cyperi and 5-15 parts of immature bitter orange. The flatulence-eliminating paste is prepared by externally applying 8 Chinese herbal medicines as raw materials according to the theory of syndrome differentiation and treatment of traditional Chinese medicine, the traditional theory of traditional Chinese medicine is applied, and a method of treating both symptoms and root causes is adopted from the whole body of a patient, the flatulence-eliminating paste has a unique curative effect on cancerous abdominal distension, the resistance and the immunity of the patient are enhanced by externally applying, the effective rate reaches more than 92%, the flatulence-eliminating paste is obviously superior to a clinically common western medicine treatment method, and the living quality of the patient achieves an ideal effect.

Description

A Chinese medicinal ointment for treating cancerous abdominal distention, and its preparation method

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a flatulence-eliminating paste for treating cancerous abdominal distension and a preparation method thereof.

Background

Abdominal distension in patients with advanced cancer is mainly caused by four factors:

1. pneumatosis in digestive tract: the qi stagnation in the digestive tract refers to enteroparalysis caused by non-mechanical compression, which is caused by the reduction or even disappearance of the peristalsis function of the intestinal tract. Usually secondary to abdominal inflammation, electrolyte disturbance, drug side effect, etc.

2. Effusion in the abdominal cavity: the albumin reduction of patients with late tumor, serious liver diseases, tumors in abdominal cavities and the like can cause the formation of ascites, a large amount of ascites not only occupies the abdominal cavity space and causes abdominal distension, but also presses the intestinal canal by the ascites to reduce the intestinal peristalsis capability, weaken the emptying effect, lead the gas retention of the intestinal canal, further cause the pneumatosis of the digestive tract and aggravate the abdominal distension.

3. And (3) postoperation secondary tumor: the resection of digestive system tumor is also one of the common causes of abdominal distension, mainly anastomotic edema, intestinal inflammatory exudation adhesion, and intestinal dysfunction caused by unreasonable diet after operation, but mostly abdominal distension in short term, with insignificant symptoms, and few cases of intestinal obstruction can develop into intestinal obstruction, and further operation treatment is needed.

4. Tumor compression: the tumors in the intestinal tract can block the intestinal tract to cause obstruction and abdominal distension. In addition, the organs in the abdominal cavity, including the liver, the gallbladder, the pancreas, the spleen, the kidney, the intestinal tract and the like, are diseased to press the intestinal tract to cause obstruction, and then abdominal distension is formed.

Specific drugs for treating abdominal distension are not available in cancer western medicine, and clinically, laxatives for relaxing bowels and cathartics and drugs for relieving distension and removing accumulation are used, but the specific drugs are usually not the primary symptoms.

Disclosure of Invention

In view of the above, the flatulence-eliminating paste is prepared by taking 8 Chinese herbal medicines as raw materials, the traditional Chinese medicine theory is applied, the method of treating both symptoms and root causes is adopted from the whole patient, the flatulence-eliminating paste has unique curative effect on cancerous ascites and hydrothorax, the resistance and immunity of the patient are enhanced by external application, the clinical treatment on more than 90 cases of cancerous abdominal distension patients proves that the effective rate reaches more than 92%, the effect is obvious, and the patient cannot have dependence and addiction on western medicines.

In order to achieve the purpose, the invention adopts the following technical scheme:

a flatulence-eliminating ointment for treating cancerous abdominal distension comprises the following raw materials in parts by weight:

10-20 parts of scorched areca nut, 5-15 parts of magnolia officinalis, 10-20 parts of fried radish seed, 5-15 parts of halite, 5-15 parts of fennel, 5-15 parts of elecampane, 5-15 parts of rhizoma cyperi and 5-15 parts of immature bitter orange.

Preferably, the flatulence-eliminating paste is prepared from the following raw materials in parts by weight:

15 parts of scorched areca seed, 10 parts of magnolia officinalis, 15 parts of fried radish seed, 10 parts of halite, 10 parts of fennel, 10 parts of costustoot, 10 parts of nutgrass galingale rhizome and 10 parts of immature bitter orange.

The invention also provides a method for preparing the carbuncle block flatulence-relieving paste, which comprises the following steps:

(5) respectively cleaning the scorched areca nuts, the mangnolia officinalis, the fried radish seeds, the halite, the fennel, the elecampane, the rhizoma cyperi and the immature bitter oranges prepared in parts by weight, drying the cleaned products until the water content is 5-10%, and then mixing the products to obtain a mixed material;

(6) under the aseptic and dustless conditions, the mixed materials are subjected to ultrasonic grinding by adopting an ultramicro grinding technology, so that the central particle size of the crude drug is below 10 mu m, and the cell wall breaking rate is over 94 percent, thereby obtaining mixed powder;

(7) carrying out five-stage atomization by adopting a nano jet atomizer, embedding and drying the mixed powder into a plurality of nano microcapsule powder at normal temperature, wherein the particle size of each nano microcapsule powder is 20-80 nanometers;

(8) adding 9-degree white vinegar into the microcapsule powder, adding water, and concocting to obtain paste with water content of 20%.

Charred Arecae semen is the processed product of Arecae semen. The quasi-circular sheet has a diameter of 1.5-3 cm and a thickness of 1-2 cm. The surface is burnt yellow, and marble-like patterns can be seen. Is crisp and fragile. Light smell, astringent and slightly bitter. The processing method comprises the following steps: the areca-nut slices are taken and fried to be brown according to a stir-frying method (a stir-frying method without auxiliary materials is called a stir-frying method).

Magnolia officinalis, also known as Magnolia officinalis, Magnolia officinalis and Magnolia officinalis in the botanical field, is a plant of Magnoliaceae and Magnoliaceae, and the Chinese medicinal material refers to the dried bark, root bark and branch bark of the plant. Stripping off root bark and branch bark for 4-6 months, directly drying in the shade, slightly boiling the dried bark in boiling water, piling up the dried bark in a shady and humid place, steaming and softening the dried bark until the inner surface of the dried bark is purple brown or tan, taking out the dried bark, rolling the dried bark into a cylinder shape, and drying. Cut into shreds and prepare ginger. Can be used for treating dyspepsia, abdominal distention, constipation, and damp obstruction of middle warmer. Can also be added into cancer medicine. Magnolia officinalis is pungent in flavor and warm in nature, and has effects of activating qi-flowing, eliminating dampness, warming middle-jiao, relieving pain, lowering adverse qi, and relieving asthma. The Magnolia officinalis decoction has strong antibacterial effect on Staphylococcus, Streptococcus, Bacillus dysenteriae, Pasteurella and Vibrio cholerae; but also has a certain relieving effect on striated muscle stiffness. Bark, root bark, flower, seed and bud can be used as the medicine, bark is the main part of the famous traditional Chinese medicine, and the medicine has the effects of resolving dampness and removing stagnancy, promoting qi circulation and relieving asthma, resolving food and eliminating phlegm, and dispelling pathogenic wind and easing pain; the seeds have the effects of improving eyesight and benefiting qi, and can be used as gynecological medicines. The functions are as follows: promoting qi circulation and removing food retention; drying dampness and removing fullness; lowering adverse qi and relieving asthma; the main treatment is as follows: food retention and qi stagnation; abdominal distension and constipation; dampness obstructing the middle energizer, gastric fullness, vomiting and diarrhea; phlegm obstructing the adverse flow of qi; fullness in chest, dyspnea and cough. Clinical study: the function of resisting pathogenic microorganisms: in vitro experiments prove that the magnolia officinalis decoction has antibacterial effects on gram-positive bacteria such as staphylococcus, hemolytic streptococcus, pneumococcus and bordetella pertussis, and gram-negative bacteria such as bacillus anthracis, bacillus dysenteriae, typhoid bacillus, paratyphoid bacillus, vibrio cholerae, escherichia coli, proteus and bacillus subtilis. Experiments show that compared with other 61 traditional Chinese medicines, the magnolia officinalis has the strongest effect on staphylococcus albus, bacillus subtilis, escherichia coli and typhoid bacillus, the effect on the staphylococcus albus and the bacillus subtilis is a sterilization effect, the magnolia officinalis has a stronger inhibition effect on staphylococcus aureus than coptis chinensis, scutellaria baicalensis and rheum officinale in a test tube, when the decoction (1:1) is diluted to 1/640, the antibacterial effect is still stronger than that of aureomycin, and the antibacterial effect of the decoction is not damaged by heating.

The fried radish seed is a processing method of radish seed, mainly aims at helping digestion and eliminating flatulence, descending qi and resolving phlegm, and is used for treating food stagnation, abdominal distending pain, constipation, stagnation and diarrhea, phlegm stagnation and cough with dyspnea, chemical components comprise volatile oil and fatty oil, the volatile oil comprises α -, β -hexenal, β -, gamma-hexenol and the like, the fatty oil comprises a large amount of erucic acid (erucic acid), linoleic acid, linolenic acid, erucic glyceride and the like, and the radish seed (raphanin) and the radish glycoside have the functions of helping digestion and eliminating flatulence, descending qi and resolving phlegm.

Daqing salt, the name of traditional Chinese medicine. Is the crystal of chloride halite mineral halite. Distributed in inner Mongolia, Qinghai, Xinjiang, Tibet, Sichuan and other places. Has the effects of purging heat, cooling blood, improving eyesight and moistening dryness. It is commonly used for hematuria, hematemesis, bleeding of tooth and tongue, conjunctival congestion, swelling and pain, wind-eye and ulceration, toothache and constipation. The main treatment is as follows: can be used for treating hematuria, hematemesis, gingival hemorrhage, conjunctival congestion, swelling and pain, wind-eye rot, toothache, and constipation. The characteristics of the medicinal materials are as follows: the single crystals of the product are cubic and multi-prismatic, and are often connected together to form irregular blocks. The particle size is generally 0.2-2.0 cm. The large particles can be seen with funnel-shaped growth vestige in the shape of irregular pits. Bluish white or dark white, translucent; fat-like shine with some blue spots visible that are unevenly distributed. Hard and brittle, easy to break, clean in cross section and glass-like luster. Light smell, salty taste. The particles are preferably large, hollow, cubic, dark white and clean. Li Dang's book of drugs: rongyan is bitter in taste and smelly. Is a sea tide water poured mountain stone and a salt coagulated stone. The north sea is selected as Qing and the south sea is selected as Zi-Chi. ' ceramic carry scene: "captive there are nine salts: white salt and common salt, which are commonly eaten; black salt for abdominal distention and fullness; hu Yan, for deafness and eye pain; relieving salt, and treating equine ridge sore; there are also red salt, stink salt and dens equi salt, which are not eaten. Ma Chi is large salt, black salt is suspected of salty brine, soft salt is suspected of halite, and this halite is also called Hu salt, and is also called eye pain. "newly revised materia Medica: "Halitum" is named Hu Yan, Shazhou is named baldeng salt, Paizhou is named Ying-earth salt, the size of the blocks among Ying-earth stones in mountain saban of river bank is not constant, the blocks are like stone, and the burning sensation is mol. "

Fennel and the name of traditional Chinese medicine. Is dried mature fruit of Foeniculum vuLgare vuLgare Mill. In autumn, the plant is harvested when the fruit is just ripe, dried in the sun, and the fruit is removed. Pungent flavor and warm nature. It enters liver, kidney, spleen and stomach meridians. The fennel has the effects of dispelling cold, relieving pain, regulating qi and harmonizing stomach. The salt fructus Foeniculi has effects of warming kidney, dispelling cold, and relieving pain. The product is a double-suspension fruit, is cylindrical, has a slight bend, and has a length of 4-8 mm and a diameter of 1.5-2.5 mm. The surface is yellowish green or yellowish, the two ends are slightly sharp, the top is provided with a column base with yellowish brown protrusions, and the base is sometimes provided with small fruit stalks. The fruits are oblong, the back surface is provided with 5 longitudinal edges, and the joint surface is flat and wide. The cross section is slightly pentagonal, and the four sides of the back surface are approximately equal in length. Has special fragrance, slightly sweet and pungent taste. Fennel is used for cold hernia with abdominal pain, testicular tenesmus, dysmenorrhea, cold pain in the lower abdomen, abdominal distention and pain, poor appetite, vomiting and diarrhea. The salted fennel can be used for treating cold hernia with abdominal pain, testicle tenesmus, and cold abdominal pain. The book Ben Cao Hui Yan (treatise on materia Medica): herbs that warm middle energizer and promote qi flow also.

Radix aucklandiae is root of Compositae plant radix aucklandiae, and is cylindrical or flat cylindrical. The surface is yellowish brown, grey brown or tan, most of the embolus is removed, and the surface has bright longitudinal furrows and lateral root marks, and sometimes has reticular texture. Strong and specific smell, sweet first and bitter later, slight tongue prickling. Mainly used for promoting qi circulation, relieving pain, invigorating spleen and promoting digestion. Nature and taste: pungent taste; bitter; and (4) temperature. Meridian tropism: invigorating spleen; the large intestine and triple energizer meridians. The efficacy is as follows: move qi, alleviate pain, invigorate spleen and promote digestion. The main treatment is as follows: promoting qi circulation and relieving pain; to regulate the middle energizer and remove food stagnation. Hypochondriac distention in the main cell is satisfied; abdominal distending pain; belching, vomiting and diarrhea; severe after dysentery. Can be used for treating chest and abdominal pain, dysentery, tenesmus, dyspepsia, and anorexia; the middle-jiao energy is not saved; sudden deafness; biting by snake and insect; toothache. The "Pharmacopeia" (Pharmacopeia): mu Xiang is used for removing qi stagnation in lung, and Bing Lang is used for middle energizer and lower energizer and accumulation of food stagnation. The herbal decoction (Ben Cao Tang Ye): mu Xiang, in Yun from Ben Jing, can tonify qi and qi deficiency; unblocking qi leads all qi and breaks it; miscarriage prevention, spleen and stomach strengthening, and tonifying; it also can be removed from the cord. What is different from the mending of the original one? The old is the qi-breaking agent, so it is not good at tonifying. Zhuzhenheng: radix aucklandiae for regulating qi. It is pungent in flavor and ascending in qi, so it is suitable for qi stagnation. For ascending of yin fire, it can counteract fire pathogen, so it is combined with Huang Bai and Zhi mu and is often combined with mu Xiang. Compendium (compendium): mu Xiang is a herb of triple energizer qi system and can ascend and descend all qi. stagnation of qi belongs to the lung, so it is also the case of qi stagnation of the upper energizer that is relieved by the stagnation of the vital energy; the spleen-qi pertains to the spleen, so the middle energizer should be qi-stagnation, and the spleen and stomach should be fragrant; for example, qi stagnation in the large intestine may cause tenesmus, qi stagnation in the bladder may cause stranguria, and qi stagnation in the liver may cause pain, so it is indicated for qi stagnation in the lower energizer, and it is indicated for obstruction of qi.

Cyperus rotundus, named as Chinese medicine. Is dried rhizome of Cyperus rotundus L of Cyperaceae. Plucked in autumn, singed to remove hair, boiled in boiling water or dried in the sun after steaming, or singed and dried in the sun directly. Pungent, slightly bitter, slightly sweet and neutral. It enters liver, spleen and triple energizer meridians. The efficacy is as follows: to soothe the liver, relieve depression, regulate qi, relieve epigastric distention, regulate menstruation and alleviate pain. The main treatment is as follows: can be used for treating stagnation of qi due to depression of the liver, distending pain in chest and hypochondrium, hernia pain, breast pain, stagnation of qi in spleen and stomach, abdominal distention, fullness and pain, menoxenia, amenorrhea, and dysmenorrhea. Compendium (compendium): cyperus rotundus has mild but not cold qi, and fragrant but fleeting flavor, and its flavor is pungent and dispersing, slightly bitter and descending, and slightly sweet.

Immature bitter orange, named as traditional Chinese medicine; dried young fruit of Citrus aurantium L.of Rutaceae and cultivar or Citrus sinensis. Citrus aurantium, Rutaceae, Citrus small arbor, dense branches and leaves, many thorns, and thorns of the bare-grown branches are 8 cm long. Picking or collecting self-falling fruits within 5-6 months, transversely cutting the fruits into two halves from the middle part, and drying in the sun or at low temperature, wherein the smaller fruits are directly dried in the sun or at low temperature. It is applied by cleaning, soaking, slicing, and drying. Unprocessed or stir-baked with bran. The book of medical science: zhi Shi is used for treating excess stomach and resolving hard mass, so it is mainly indicated for blood system in Zhongwan, treating fullness and distention between umbilicus and abdomen, eliminating phlegm nodule, removing stagnant water, dispelling indigestion, breaking and coagulating chest, relaxing bowels and block, but not for all. For itching skin, it is unable to nourish the skin surface due to blood stagnation in the middle, and for poor appetite, it is also pungent, dispersing and purging to remove the pathogenic wind and dampness due to spleen stagnation. It is the most important herb for qi in blood. Zhi Shi and Hou Po can treat constipation due to food stagnation, remove tangible and full, and also treat damp-stagnation damaging the middle energizer, and loose and full. However, Zhi Shi is good at descending and descending with bitter flavor, and is good at relieving food stagnation and relaxing bowels and close, so it is good for full, while Zhi Shi is unprocessed with sharp flavor and slow frying strength. Hou Po is bitter in flavor and warm in property and strong in action of drying dampness and dissipating fullness, so it is good at drying dampness and resolving phlegm. Hou Po and Zhi Shi are often combined for moving qi and removing food stagnation, but Hou Po is bitter and pungent in flavor and warm in nature and slow in moving qi, so it is good at drying dampness and dispersing fullness, and can descend qi and relieve dyspnea; zhi Shi is bitter in taste and cold in nature and strong in action of breaking qi, so it is good at resolving phlegm and relieving stuffiness and has the actions of resolving food stagnation and removing food stagnation. Immature bitter orange for treating chest pain: pounded immature bitter orange (powder), it should be taken twice daily, an ancient type of spoon cun and twice night. ("supplement posterior cubitus"). Zhi Shi is indicated for fullness, promoting digestion and strengthening stomach: two bighead atractylodes rhizome, two and two immature bitter orange (stir-fried with bran to yellow, removed pulp). The above materials are mixed into fine powder, wrapped with lotus leaf and fried, and cooked into pills, which are as big as phoenix tree seed. Fifty pills are taken every time, which is usually done in white soup. Zhishu Wan from Bishang Shang Bian (differentiation of internal and external injury). For chest stuffiness, stuffiness and fullness in the heart, qi accumulation in the chest, fullness in the chest, hypochondrium, adverse attack on the heart: four immature bitter oranges, four or two magnolia officinalis, half liter of allium macrostemon, two or one cassia twig and one trifoliate orange fruit. Decocting fructus Aurantii Immaturus and cortex Magnolia officinalis with water for five liters, taking two liters, removing residues, adding the above materials, decocting for several times, and taking three times with warm water. ("jin Kui Yao L ü e" (in immature bitter orange, Allium macrostemon and Cinnamomum cassia twig decoction).

The invention has the beneficial effects that:

(1) the invention discloses a flatulence-relieving paste which is prepared from 8 Chinese herbal medicines, and is prepared by applying the theory of treatment based on syndrome differentiation of traditional Chinese medicine, starting from regulating qi and activating blood circulation, and assisting with the drug effects of promoting digestion, relieving distension, descending qi, relieving fullness, regulating menstruation and relieving pain, so as to finally achieve the purpose of treating cancerous abdominal distension, wherein the areca nut is scorched: promoting digestion, removing food stagnation, descending qi, and promoting water circulation; magnolia officinalis: eliminating dampness and phlegm, descending qi and eliminating fullness; frying radish seeds: promoting digestion, relieving flatulence, descending qi and resolving phlegm; halite: purging heat, cooling blood, improving eyesight, moistening dryness; fennel: dispelling cold, relieving pain, regulating qi-flowing and regulating stomach; costustoot: promoting qi circulation, relieving pain, invigorating spleen, and promoting digestion; rhizoma cyperi: promoting qi circulation, resolving stagnation, regulating menstruation, and relieving pain; immature bitter orange: break qi and remove food retention, resolve phlegm and disperse distention and fullness. The medicines are mutually compatible to achieve the effect of relieving distension.

(2) The invention adopts 8 Chinese herbal medicines to prepare external paste according to the formula, and the external paste is externally applied, can strengthen the spleen to promote digestion, promote diuresis and eliminate water, promote qi and blood circulation, remove blood stasis and dissipate stagnation, and achieves the purpose of treating cancerous abdominal distension and pain. The traditional Chinese medicine composition is suitable for various cancerous abdominal distension, such as tumors in abdominal cavities, and the like, and is used for treating more than 90 cases of cancerous abdominal distension patients and enhancing the resistance and immunity of the patients in the clinical application process, wherein the effective rate of the treatment is more than 92 percent, and the survival quality of the patients reaches the result which is difficult to reach by western medicine.

(3) The invention grinds the raw materials into powder, carries out ultrasonic micro-powder and five-stage atomization embedding, utilizes the methods of micro-ecology and bionics, by means of biological grafting, the intestinal environment of human body and the digestion and decomposition process of Chinese medicine components in human body are simulated in vitro, biologically converting the extracted effective components of the traditional Chinese medicine, converting macromolecular substances of the traditional Chinese medicine into small molecular components which can be directly absorbed by intestinal tracts of human bodies through microorganisms, completely eliminating the harmful toxicity of each medicine through the 8 kinds of Chinese herbal medicines which are predigested and converted, and enabling the formed ointment to have quantitative curative effect and be quickly absorbed by human bodies, compared with the traditional Chinese medicine, the medicine effect is improved by 8-24 times, the effective components in the medicinal materials can be completely extracted, thereby solving the problems of slow treatment effect and inaccurate treatment effect of the medicine prepared by adopting the same raw materials.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Example 1

10 parts of scorched areca nut, 5 parts of magnolia officinalis, 10 parts of fried radish seed, 5 parts of halite, 5 parts of common fennel, 5 parts of costustoot, 5 parts of nutgrass galingale rhizome and 5 parts of immature bitter orange.

The preparation method of the flatulence-eliminating paste comprises the following steps:

1. mixing materials: the scorched areca, the mangnolia officinalis, the fried radish seed, the halite, the fennel, the elecampane, the rhizoma cyperi and the immature bitter orange which are prepared in parts by weight are respectively cleaned, dried until the water content is 5-10%, and then mixed to obtain a mixed material.

2. Crushing materials: and (3) carrying out ultrasonic grinding on the mixed material by adopting an ultramicro grinding technology under the aseptic and dustless conditions to ensure that the central particle size of the crude drug is less than 10 microns, preferably 5-6 microns, and the cell wall breaking rate is more than 94%, thus obtaining the mixed powder. Through ultrasonic pulverization, the active ingredients in the medicinal composition are directly exposed, so that the medicinal composition is more quickly and completely dissolved and takes effect; wherein the particle fineness of the mixed powder is not less than 200 meshes.

3. Embedding: carrying out five-stage atomization by adopting a nano jet atomizer, embedding and drying the mixed powder into a plurality of nano microcapsule powder at normal temperature, wherein the particle size of each nano microcapsule powder is 20-80 nanometers, preferably 20-40 micrometers; therefore, the active ingredients of the medicine are prevented from volatilizing, and the medicine is easily and directly absorbed by the skin of a human body, so that the active substances play a role, the bioavailability of the medicine is improved, and the medicine effect is improved. The process of five-stage atomization by adopting the nano jet atomizer comprises the following steps: the concentrated solution is atomized by five stages at normal temperature, namely the concentrated solution is brought into the jet flow spray cavity by high-pressure airflow through the liquid inlet pipe, the spraying speed of each stage is more than 800 m/s, and finally the concentrated solution is sprayed out from the jet hole of the jet flow spray nozzle.

4. Paste preparation: adding 9 degree white vinegar into the microcapsule powder, adding water, and concocting to obtain paste with water content of 20% for external use. Wherein the modulating comprises: heating to boil with strong fire, decocting with small fire at 50-60 deg.C, and concentrating.

In addition, after the paste is prepared, the paste can be subjected to anaerobic fermentation for 2 months at normal temperature, so that the blocky distension-relieving paste is obtained, and is convenient to transport and store.

Example 2

3. Embedding: carrying out five-stage atomization by adopting a nano jet atomizer, embedding and drying the mixed powder into a plurality of nano microcapsule powder at normal temperature, wherein the particle size of each nano microcapsule powder is 40 nanometers; therefore, the active ingredients of the medicine are prevented from volatilizing, and the medicine is easily and directly absorbed by the skin of a human body, so that the active substances play a role, the bioavailability of the medicine is improved, and the medicine effect is improved. The process of five-stage atomization by adopting the nano jet atomizer comprises the following steps: the concentrated solution is atomized by five stages at normal temperature, namely the concentrated solution is brought into the jet flow spray cavity by high-pressure airflow through the liquid inlet pipe, the spraying speed of each stage is more than 800 m/s, and finally the concentrated solution is sprayed out from the jet hole of the jet flow spray nozzle.

4. Paste preparation: adding 9 degree white vinegar into the microcapsule powder, adding water, and concocting to obtain paste with water content of 20% for external use. The modulation comprises: heating to boil with strong fire, decocting with small fire at 50-60 deg.C, and concentrating.

Example 3

20 parts of sweet and burnt areca, 15 parts of mangnolia officinalis, 10 parts of fried radish seed, 15 parts of halite, 15 parts of fennel, 15 parts of elecampane, 15 parts of rhizoma cyperi and 15 parts of immature bitter orange.

2. Crushing materials: ultrasonically pulverizing the above mixture under sterile and dustless conditions to obtain crude drug with center particle diameter of 10 μm or less, such as 4 μm, preferably 5-6 μm, and cell wall breaking rate of 94% or more, to obtain mixed powder. Through ultrasonic pulverization, the active ingredients in the medicinal composition are directly exposed, so that the medicinal composition is more quickly and completely dissolved and takes effect; wherein the particle fineness of the mixed powder is not less than 200 meshes.

3. Embedding: carrying out five-stage atomization by adopting a nano jet atomizer, embedding and drying the mixed powder into a plurality of nano microcapsule powder at normal temperature, wherein the particle size of each nano microcapsule powder is 30 nanometers; therefore, the active ingredients of the medicine are prevented from volatilizing, and the medicine is easily and directly absorbed by the skin of a human body, so that the active substances play a role, the bioavailability of the medicine is improved, and the medicine effect is improved. The process of five-stage atomization by adopting the nano jet atomizer comprises the following steps: the concentrated solution is atomized by five stages at normal temperature, namely the concentrated solution is brought into the jet flow spray cavity by high-pressure airflow through the liquid inlet pipe, the spraying speed of each stage is more than 800 m/s, and finally the concentrated solution is sprayed out from the jet hole of the jet flow spray nozzle.

4. Paste preparation: adding 9-degree white vinegar into the microcapsule powder, adding water, and concocting to obtain paste with water content of 20%. The modulation comprises: heating to boil with strong fire, decocting with small fire at 50-60 deg.C, and concentrating.

The following description will further illustrate the beneficial effects of the topical medicament of the present invention through clinical case statistics using the distension-relieving ointment obtained in example 2.

The clinical cases of the current time are 92 cases, each half of men and women, the age is 50-75 years, the average age is 60 years, and the cases comprise liver cancer, gastric cancer, intestinal cancer and ovarian cancer.

1. Cancer pain observation

(1) Assessment of pain

No pain 0, severe pain 100;

(2) intensity of pain

0-no pain; 1-mild discomfort; 2-discomfort; 3-difficulty in handling; 4-feared pain; 5-extreme pain;

2. criteria for therapeutic effect

The effect is shown: the pain integral value after treatment is reduced by more than or equal to 70 percent compared with the integral value before treatment.

The method has the following advantages: the pain integral value after treatment is reduced by more than or equal to 30 percent and less than 70 percent compared with the integral value before treatment.

And (4) invalidation: the post-treatment pain integrated value was < 30% lower than the pre-treatment integrated value.

Note: calculation formula (nimodipine method): [ (integration before treatment-integration after treatment) ÷ integration before treatment ] × 100%.

3. Therapeutic results

The anti-swelling ointment is used for treating 92 cancer pains, wherein 45 cases of the anti-swelling ointment have obvious effects, 40 cases of the anti-swelling ointment have effects, 7 cases of the anti-swelling ointment have no effects, the total effective rate reaches 92.39%, the anti-swelling ointment is generally called to relieve abdominal distension within 30-40 minutes after external application of the anti-swelling ointment for treated effective patients, dependence and addiction of other commonly taken analgesics such as non-opioid analgesics or opioid analgesics are avoided, the anti-swelling ointment is continuously used for 10-20 days, and the pain effect is obviously reduced.

Example of the medical record 1

Liu, male, age 66, retired worker. Initial diagnosis at 18 months 4 in 2012, and the chief complaints are: the liver was found to be blocked for more than 1 month. The patient feels the feeling of abdominal fullness before 1 month, the liver area is dull and painful, and the body weight is gradually reduced with asthenia. The history of hepatitis is 13 years. Prompting abdominal ultrasound and CT examination: nodules of 5cm multiplied by 5cm and 3cm multiplied by 3cm are seen in the right liver lobe, moderate cirrhosis, and positive detection of alpha-fetoprotein. Then, the tissue biopsy is carried out under the ultrasonic guidance of a hospital in the transportation city center, and the primary liver cancer is confirmed by pathological section examination. Patients refused surgery and were treated conservatively. The symptoms are sallow complexion, paroxysmal dull pain in the liver area, stuffiness and hardness in the epigastrium, abdominal distension and no appetite, listlessness and dry stool. A deep-red tongue with no coating and a thready, wiry and rapid pulse. The traditional Chinese medicine diagnosis is as follows: the pattern of liver fullness is due to qi stagnation and blood stasis. The medicine is externally applied to the pain part for 2-3 hours every day, the pain is relieved after continuous treatment for 15 days, and the patient is subjected to a repeated diagnosis after 1 month, so that the pain can be tolerated during the use period, and the appetite is improved.

Example of the medical record 2

Chen and Fu ren, 63 years old, first diagnosis in 11 months and 4 days in 2013. The main complaints are: the abdominal pain is more than 3 months. The patient had abdominal pain and weight loss 3 months ago. The local hospital has performed gastrointestinal barium transudation, which prompts the patient to ascend colon cancer, refuses surgery and chemotherapy, and seeks traditional Chinese medicine conservative treatment. The symptoms include persistent abdominal pain, painful face, listlessness, anorexia, poor sleep, chest distress, short breath, loose stool, purulent blood, aversion to cold, cold limbs, pale red tongue, white greasy coating, deep, thready and intermittent pulse. Physical examination: the whole abdomen is flat and soft, the right abdomen is tenderness, the rebound pain is negative, and the percussion pain of the kidney and liver regions is negative. Traditional Chinese medicine diagnosis: abdominal pain (spleen and kidney deficiency, blood stasis obstructing collaterals). The medicine is continuously used for 10 days, the medicine is externally used for 1-2 hours at a pain position every day, the time can be properly increased according to the situation, the pain is relieved, the self-describing abdominal pain disappears after 3 weeks of repeated diagnosis, and the weight is increased.

Cancerous abdominal pain is a particular type of pain that is a common symptom in patients with mid-and late-stage cancer, the cause of which is directly related to the malignancy. From the clinical point of view, the pathogenesis of cancer pain is characterized by deficiency and excess mixed, the deficiency is caused by healthy qi damage, the excess is qi stagnation, blood stasis and the like, and the treatment generally aims at strengthening healthy qi and eliminating evil to dredge and relieve pain. The traditional Chinese medicine has definite clinical curative effect on cancerous abdominal distension, and plays a great role in relieving pain in a plurality of middle and late cancer patients. The traditional Chinese medicine has slow and lasting analgesic effect, has the advantages of no addiction, drug resistance, little toxic and side effect and the like, and greatly enriches the content of first and second gradient (non-morphine drugs) cancer pain treatment. Through a large number of clinical verifications, the invention can improve the life quality and the immunologic function of patients, has high safety and definite curative effect, and is worthy of popularization. The traditional advantages are obvious in clinical practice of treating cancerous abdominal distension, and the development and application in the future also have wide prospects.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The flatulence-eliminating ointment for treating cancerous abdominal distension is characterized by comprising the following raw materials in parts by weight:

2. The carbuncle block flatulence-eliminating paste as claimed in claim 1, which is prepared from the following raw materials in parts by weight:

3. A method of preparing an anti-distension paste according to any one of claims 1-2, comprising the steps of:

(1) respectively cleaning the scorched areca nuts, the mangnolia officinalis, the fried radish seeds, the halite, the fennel, the elecampane, the rhizoma cyperi and the immature bitter oranges prepared in parts by weight, drying the cleaned products until the water content is 5-10%, and then mixing the products to obtain a mixed material;

(2) under the aseptic and dustless conditions, the mixed materials are subjected to ultrasonic grinding by adopting an ultramicro grinding technology, so that the central particle size of the crude drug is below 10 mu m, and the cell wall breaking rate is over 94 percent, thereby obtaining mixed powder;

(3) carrying out five-stage atomization by adopting a nano jet atomizer, embedding and drying the mixed powder into a plurality of nano microcapsule powder at normal temperature, wherein the particle size of each nano microcapsule powder is 20-80 nanometers;

(4) adding 9-degree white vinegar into the microcapsule powder, adding water, and concocting to obtain paste with water content of 20%.

4. The production method according to claim 3, wherein the particle fineness of the mixed powder in the step (2) is not less than 200 mesh.

5. The method according to claim 3, wherein the preparing in step (4) comprises: heating to boil with strong fire, and decocting with slow fire at 50-60 deg.C.

6. The method according to claim 3, wherein in the step (2), the particle diameter of the crude drug at the center is 5 to 6 μm.