CN103070998B - Externally-applied plaster for curing pain of rheumatic joints - Google Patents
Externally-applied plaster for curing pain of rheumatic joints Download PDFInfo
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- CN103070998B CN103070998B CN201310006163.6A CN201310006163A CN103070998B CN 103070998 B CN103070998 B CN 103070998B CN 201310006163 A CN201310006163 A CN 201310006163A CN 103070998 B CN103070998 B CN 103070998B
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- 239000011505 plaster Substances 0.000 title claims abstract description 12
- 208000002193 Pain Diseases 0.000 title claims abstract description 11
- 206010072736 Rheumatic disease Diseases 0.000 title abstract description 7
- 230000000552 rheumatic Effects 0.000 title abstract 3
- 210000001503 Joints Anatomy 0.000 title abstract 2
- 241000903946 Clematidis Species 0.000 claims abstract description 9
- 241000218176 Corydalis Species 0.000 claims abstract description 9
- DSSYKIVIOFKYAU-UHFFFAOYSA-N Camphor Chemical compound C1CC2(C)C(=O)CC1C2(C)C DSSYKIVIOFKYAU-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960000846 Camphor Drugs 0.000 claims abstract description 7
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 4
- 229930007890 camphor Natural products 0.000 claims abstract description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 9
- 241001163443 Daphne giraldii Species 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 8
- 241000180649 Panax notoginseng Species 0.000 claims description 8
- 235000012907 honey Nutrition 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 6
- 229960003639 Laurocapram Drugs 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- -1 stir Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 241000725145 Homalomena Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 235000019388 lanolin Nutrition 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 20
- 208000006820 Arthralgia Diseases 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 9
- 229940079593 drugs Drugs 0.000 abstract description 6
- 241000758794 Asarum Species 0.000 abstract 1
- 210000004369 Blood Anatomy 0.000 abstract 1
- 240000005801 Carthamus tinctorius Species 0.000 abstract 1
- 241000934856 Daphne Species 0.000 abstract 1
- 241000123866 Homalomena occulta Species 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 241000208682 Liquidambar Species 0.000 abstract 1
- 235000006552 Liquidambar styraciflua Nutrition 0.000 abstract 1
- 241000195954 Lycopodium clavatum Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 240000004678 Panax pseudoginseng Species 0.000 abstract 1
- 241000331449 Vincetoxicum pycnostelma Species 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000002365 multiple layer Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001737 promoting Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 12
- 210000003205 Muscles Anatomy 0.000 description 3
- 229940025250 camphora Drugs 0.000 description 3
- 239000010238 camphora Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 201000003068 rheumatic fever Diseases 0.000 description 3
- 230000001225 therapeutic Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 210000002615 Epidermis Anatomy 0.000 description 2
- 206010022114 Injury Diseases 0.000 description 2
- 210000003491 Skin Anatomy 0.000 description 2
- 210000002784 Stomach Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000000988 Bone and Bones Anatomy 0.000 description 1
- 210000002808 Connective Tissue Anatomy 0.000 description 1
- 241000668709 Dipterocarpus costatus Species 0.000 description 1
- 210000003414 Extremities Anatomy 0.000 description 1
- 210000000987 Immune System Anatomy 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 206010023232 Joint swelling Diseases 0.000 description 1
- 210000003734 Kidney Anatomy 0.000 description 1
- 210000004185 Liver Anatomy 0.000 description 1
- 206010024770 Local swelling Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 description 1
- 208000008552 Soft Tissue Injury Diseases 0.000 description 1
- 210000004304 Subcutaneous Tissue Anatomy 0.000 description 1
- 210000001835 Viscera Anatomy 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000202 analgesic Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029578 entry into host Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 201000005569 gout Diseases 0.000 description 1
- 230000001861 immunosuppresant Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001617 migratory Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 230000001537 neural Effects 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drugs Drugs 0.000 description 1
- 230000000414 obstructive Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
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- 230000001047 pyretic Effects 0.000 description 1
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- 230000002522 swelling Effects 0.000 description 1
- 201000010874 syndrome Diseases 0.000 description 1
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Abstract
The invention provides an externally-applied plaster for curing pain of rheumatic joints. The externally-applied plaster is mainly composed of the following components: radix angelicae pubescentis, corydalis tuber, safflower carthamus, homalomena occulta, lycopodium clavatum, girald daphne bark, radix clematidis, beautiful sweetgum fruit, pseudo-ginseng, ligusticum wallichii, asarum, cynanchum paniculatum, radix angelicae, camphor, and the like. The externally-applied plaster has effects of dispelling wind and eliminating dampness, stretching channels and dredging collaterals, and promoting blood circulation to remove blood stasis. The drug is different from conventional treatment scheme only used for curing pain of rheumatic pain joints, adopts an external treatment strapping, has multiple layers and targets, achieves prevention and treatment, treats both symptoms and root causes, and has a unique treatment method and reliable curative effect.
Description
Technical field
The present invention relates to a kind of external patch unguentum for the treatment of rheumatalgia arthralgia.
Background technology
Rheumatalgia arthralgia is rheumatism volume cardinal symptom, and rheumatism refers to take muscle, arthralgia as a main class disease.The connective tissue of major effect health may be that immune system injury causes.The traditional Chinese medical science thinks that impatency passages through which vital energy circulates causes due to the exopathogen such as wind, cold, wet, heat invasion and attack human body.Motherland's medical science early has penetrating record to this disease.Alleged " severe and migratory arthralgia ", " gout ", " numbness " etc. of ancient medicine is all as this class disease, think many and invade in an opponent's defence human body by wind-cold damp pathogen gas, or have an intrinsic heat, the heat-transformation of a specified duration of wind and cold damp-stagnancy, the meridians of being detained, inaccessible obstructed forming, if with the passing of time do not heal, deficiency of both the liver and kidney, muscles and bones is lost in moistening foster, so that joint deformity is stiff.
In general, suffering from cold, humidity, fatigue, psychic trauma, malnutrition, wound etc., is often the risk factor of primary disease.Main clinical manifestation is joint, muscle, neural acid, swollen, pain, swollen, cold, numb, meets cold rnning weight, obtains hot slow.At present, doctor trained in Western medicine there is no specific medicament, and traditional Chinese medical science Chinese medicine for oral administration trouble is inconvenient, and has the intestines and stomach to stimulate.
Rheumatism is a kind of commonly encountered diseases, frequently-occurring disease.Along with the aging of population, the number of patients showed increased of such disease.In recent years, rheumatismal Progress in Medication major embodiment is following several respects:
(1) nonsteroidal antiinflammatory drug is constantly updated.(2) slow-acting drug: this type of medicine also claims to improve state of an illness medicine.(3) immunosuppressant.(4) glucocorticoid.(5) biological preparation.(6) transplantation therapy.(7) other rheumatism treatment medicines.But western medicine exists, and side effect is large, expense is high, treat the shortcomings such as thorough, easy recurrence.
Summary of the invention
The object of the invention is for the deficiencies in the prior art, a kind of external plaster for the treatment of Fengshi Guanjie pain is provided, this curative effect of medicine is high, and expense is low, easy to use simple and direct, has no side effect, and is difficult for more afterwards recurrence.
The present invention treats the external plaster of Fengshi Guanjie pain, is made up of by weight following bulk drugs:
90～120 parts of Radix Angelicae Pubescentiss, 80～100 parts of Rhizoma Corydalis, 80～100 parts of Herba Asaris, 30～50 parts, Flos Carthami, 40～60 parts of Rhizoma Homalomenaes, 30～50 parts of Herba Lycopodiis, 40～60 parts of Daphne giraldii Nitsche, 30～50 parts of Radix Clematidis, 40～60 parts of Fructus Liquidambaris, 30～60 parts of Radix Notoginseng, 30～50 parts of Rhizoma Chuanxiongs, 30～50 parts of Radix Cynanchi Paniculatis, 40～60 parts of the Radixs Angelicae Dahuricae, 20～40 parts of Camphoras, 10～20 parts of laurocaprams, 150～250 parts of refined honeys, 100～250 parts of lanolines, 70～150 parts of propylene glycol.
The preparation method of this plaster is: Radix Angelicae Pubescentis, Rhizoma Corydalis, Rhizoma Homalomenae, Daphne giraldii Nitsche, Radix Notoginseng, Rhizoma Chuanxiong, Herba Asari, the Radix Angelicae Dahuricae, camphor powder is broken into fine powder (crossing 100 mesh sieves), mixes, and for subsequent use; Flos Carthami, Herba Lycopodii, Radix Clematidis, Fructus Liquidambaris, Radix Cynanchi Paniculati add the decocting of 8 times of amounts to boil 2 hours, filter, and medicinal residues add 6 times of water gagings to decoct 1.5 hours, filter, and merging filtrate, is concentrated into relative density 1.20～1.25(60 ℃) clear paste; After refined honey, lanoline, propylene glycol heating and melting, constantly stir, add laurocapram to continue stirring and evenly mixing, in the time that temperature is down to 45～55 ℃, add above-mentioned clear paste to stir, mix; Add above-mentioned fine powder, stir, mix, cream core processed, and be placed in sticker, to obtain final product.
Feature of the present invention
1, technical breakthrough, the present invention adopts unique transdermal drag delivery, multi-faceted dispenser at many levels,, effectively improve the ability of medicament through epidermis, solve that medicine is in the past difficult to see through epidermis collenchyme and a difficult problem of eradicating rapidly rheumatalgia arthralgia, guarantee the therapeutic effect of rheumatalgia arthralgia, prevent recurrence.
2, directly impose on affected part, Transdermal absorption, medicine directly infiltrates focus deep skin tissue.Avoid the loss of medication amount and the poisoning to human viscera organ.
3, fully demonstrate tcm characteristic and advantage, product is through a large amount of clinical verifications, and it is to epiderm skin tissue, subcutaneous tissue not damaged, and nonirritant, has no side effect.Be the therapy of summing up clinical experience for many years and gains in depth of comprehension and create out simple and direct practicability and effectiveness external treatment, solved a difficult problem how to eliminate the cause of disease, solved a difficult problem for deep medicament infiltration.
Adopt external treatment treatment rheumatic arthritis 46 examples, obtain satisfied effect, be reported as follows.
1. physical data
Male's 20 examples in this law treatment, women's 26 examples; 10～80 years old age, average 43.5 years old; The course of disease 3 months～8 years, average 4.7 years.
2. Therapeutic Method
External, clean affected part.When use, open the separate paper of patch, be affixed on painful area or effect point-application, each one pastes, and every subsides are used 1～3 day, or follow the doctor's advice.It within 7 days, is 1 course for the treatment of.Be used in conjunction the 2-3 course for the treatment of.
3. therapeutic effect
Criterion of therapeutical effect: recovery from illness: limbs joint pain, swelling, the symptoms such as joint stuffiness all disappear in 3 courses for the treatment of, overcast and rainy and tired after without sense of discomfort; Effective: symptom disappears substantially, overcast and rainy and tired after sense of discomfort slightly; Effective: transference cure more than 80%, still has mild pain and sour reinfection, overcast and rainy increasing the weight of, limitation of movement; Invalid: after 3 courses for the treatment of, symptom is not improved.
Through this law treatment recovery from illness 26 examples, effective 18 examples, effective 1 example, invalid 1 example, total effective rate 97.6%.After half a year, following up a case by regular visits to relapse rate is 4.3%, and recurrent cases adopts this law treatment still effective.
Model case
Lee, female, 60 years old, first visit on November 10 in 2009.The right gonalgia of patient, meets cold increasing the weight of, joint stuffiness 6 years, and within nearly 1 month, symptom increases the weight of, and right knee joint swelling is obvious, and multi-treatment is invalid.Be diagnosed as rheumatic arthritis.Impose this law external treatment, after 2 days, local swelling disappears substantially.The walking of can leaving the bed after 6 days, after 3 weeks, activity freely.Follow up a case by regular visits to and within 1 year, have no recurrence.
4. conclusion
This law dehumidifies with dispersing wind and cold, removing obstruction in the collateral to relieve pain and making laws, and act on part, and through sick institute, the fraud of damaging stomach without impairment of YANG, easy to use again, can yet be regarded as and treat the desirable effective ways of rheumatic arthritis.The joint that this patch causes proliferative arthritis, soft tissue injury and around pain also have good analgesic effect.Differentiation of symptoms and signs for classification of syndrome belongs to wind, cold, wet numbness type person effect and is better than wind, wet, pyretic arthralgia type.
Accompanying drawing explanation
Fig. 1 is the production technological process of plaster.
The specific embodiment
Embodiment 1 presses column weight amount weighting raw materials (unit: g)
Radix Angelicae Pubescentis 100g, Rhizoma Corydalis 80g, Herba Asari 85g, Flos Carthami 35g, Rhizoma Homalomenae 50g, Herba Lycopodii 45g, Daphne giraldii Nitsche 55g, Radix Clematidis 45g, Fructus Liquidambaris 50g, Radix Notoginseng 45g, Rhizoma Chuanxiong 40g, Radix Cynanchi Paniculati 45g, Radix Angelicae Dahuricae 45g, Camphora 25g, laurocapram 15g, refined honey 220g, lanoline 120g, propylene glycol 80g.
Embodiment 2 presses column weight amount weighting raw materials (unit: g)
Radix Angelicae Pubescentis 105g, Rhizoma Corydalis 85g, Herba Asari 80g, Flos Carthami 40g, Rhizoma Homalomenae 45g, Herba Lycopodii 40g, Daphne giraldii Nitsche 50g, Radix Clematidis 40g, 55 parts of Fructus Liquidambaris, 50 parts of Radix Notoginseng, Rhizoma Chuanxiong 45g, Radix Cynanchi Paniculati 40g, Radix Angelicae Dahuricae 50g, Camphora 30g, laurocapram 15g, refined honey 220g, lanoline 120g, propylene glycol 80g.
Embodiment 3 presses column weight amount weighting raw materials (unit: g) (modification consumption)
Radix Angelicae Pubescentis 110g, Rhizoma Corydalis 90g, Herba Asari 90g, Flos Carthami 30g, Rhizoma Homalomenae 40g, Herba Lycopodii 50g, Daphne giraldii Nitsche 40g, Radix Clematidis 30g, Fructus Liquidambaris 40g, Radix Notoginseng 55g, Rhizoma Chuanxiong 30g, Radix Cynanchi Paniculati 50g, Radix Angelicae Dahuricae 55g, Camphora 35g, laurocapram 15g, refined honey 220g, lanoline 120g, propylene glycol 80g.
The preparation method of above embodiment is as follows:
In writing out a prescription, each taste Chinese crude drug is according to the clean system of regulation under Chinese Pharmacopoeia and this kind item of drug standard, the preparation method of plaster is: Radix Angelicae Pubescentis, Rhizoma Corydalis, Rhizoma Homalomenae, Daphne giraldii Nitsche, Radix Notoginseng, Rhizoma Chuanxiong, Herba Asari, the Radix Angelicae Dahuricae, camphor powder are broken into fine powder (crossing 100 mesh sieves), mix, for subsequent use; Flos Carthami, Herba Lycopodii, Radix Clematidis, Fructus Liquidambaris, Radix Cynanchi Paniculati add the decocting of 8 times of amounts to boil 2 hours, filter, and medicinal residues add 6 times of water gagings to decoct 1.5 hours, filter, and merging filtrate, is concentrated into relative density 1.20～1.25(60 ℃) clear paste; After refined honey, lanoline, propylene glycol heating and melting, constantly stir, add laurocapram to continue stirring and evenly mixing, in the time that temperature is down to 45～55 ℃, add above-mentioned clear paste to stir, mix; Add above-mentioned fine powder, stir, mix, cream core processed, and be placed in sticker, to obtain final product.
Using method: external, clean affected part.When use, open the separate paper of patch, be affixed on painful area or effect point-application, each one pastes, and every subsides are used 1～3 day, or follow the doctor's advice.
Claims (1)
1. treat an external plaster for Fengshi Guanjie pain, it is characterized in that being made by weight by following raw materials according:
90～120 parts of Radix Angelicae Pubescentiss, 80～100 parts of Rhizoma Corydalis, 80～100 parts of Herba Asaris, 30～50 parts, Flos Carthami, 40～60 parts of Rhizoma Homalomenaes, 30～50 parts of Herba Lycopodiis, 40～60 parts of Daphne giraldii Nitsche, 30～50 parts of Radix Clematidis, 40～60 parts of Fructus Liquidambaris, 30～60 parts of Radix Notoginseng, 30～50 parts of Rhizoma Chuanxiongs, 30～50 parts of Radix Cynanchi Paniculatis, 40～60 parts of the Radixs Angelicae Dahuricae, 20～40 parts of Camphoras, 10～20 parts of laurocaprams, 150～250 parts of refined honeys, 100～250 parts of lanolines, 70～150 parts of propylene glycol;
The preparation method of above-mentioned plaster is: Radix Angelicae Pubescentis, Rhizoma Corydalis, Rhizoma Homalomenae, Daphne giraldii Nitsche, Radix Notoginseng, Rhizoma Chuanxiong, Herba Asari, the Radix Angelicae Dahuricae, camphor powder is broken into fine powder, crosses 100 mesh sieves, mix, and for subsequent use; Flos Carthami, Herba Lycopodii, Radix Clematidis, Fructus Liquidambaris, Radix Cynanchi Paniculati add the decocting of 8 times of amounts to boil 2 hours, filter, and medicinal residues add 6 times of water gagings to decoct 1.5 hours, filter merging filtrate, the clear paste that while being concentrated into 60 ℃, relative density is 1.20～1.25; After refined honey, lanoline, propylene glycol heating and melting, constantly stir, add laurocapram to continue stirring and evenly mixing, in the time that temperature is down to 45～55 ℃, add above-mentioned clear paste to stir, mix; Add above-mentioned fine powder, stir, mix, cream core processed, and be placed in sticker, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310006163.6A CN103070998B (en) | 2012-02-27 | 2013-01-08 | Externally-applied plaster for curing pain of rheumatic joints |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210045992.0 | 2012-02-27 | ||
| CN2012100459920A CN102579719A (en) | 2012-02-27 | 2012-02-27 | Externally applied plaster for treating rheumatoid arthralgia |
| CN201310006163.6A CN103070998B (en) | 2012-02-27 | 2013-01-08 | Externally-applied plaster for curing pain of rheumatic joints |
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| Publication Number | Publication Date |
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| CN103070998A CN103070998A (en) | 2013-05-01 |
| CN103070998B true CN103070998B (en) | 2014-05-14 |
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| CN2012100459920A Pending CN102579719A (en) | 2012-02-27 | 2012-02-27 | Externally applied plaster for treating rheumatoid arthralgia |
| CN201310006163.6A Active CN103070998B (en) | 2012-02-27 | 2013-01-08 | Externally-applied plaster for curing pain of rheumatic joints |
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| CN2012100459920A Pending CN102579719A (en) | 2012-02-27 | 2012-02-27 | Externally applied plaster for treating rheumatoid arthralgia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361923A (en) * | 2008-09-11 | 2009-02-11 | 周功庚 | Traditional Chinese medicine for treating rheumatism |
| CN101721498A (en) * | 2008-10-24 | 2010-06-09 | 常涛 | Medicine for treating rheumatism |
| AU2009101063A4 (en) * | 2009-10-21 | 2010-02-25 | G & W Aust Pty Ltd | Herbal compositions and uses for male support, male well-being, sexual performance and normal sexual libido |
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| CN103070998A (en) | 2013-05-01 |
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Effective date of registration: 20210425 Address after: 237000 Anhui city of Lu'an Province Economic and Technological Development Zone Heng Yuan Patentee after: ANHUI SHILONG BIOMEDICAL TECHNOLOGY Co.,Ltd. Address before: 710075 hi tech three road wealth center, hi tech Zone, Shaanxi, Xi'an Patentee before: Wang Shilong |