CN108186749A - Treat Chinese medicine composition of cervical spondylosis and preparation method thereof - Google Patents
Treat Chinese medicine composition of cervical spondylosis and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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Abstract
The present invention relates to Chinese medicine preparation technical fields, disclose a kind of Chinese medicine composition and preparation method for treating cervical spondylosis, which is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 10~20, Radix Angelicae Pubescentis 10~20, turpentine 30~40, lycopodium calvatum 10~20, windproof 20~30, Caulis Spatholobi 9~19, Rhizoma Chuanxiong 30~40, cortex acanthopanacis 10~20, the root of Chinese clematis 10~20, Radix Notoginseng 10~20, safflower 10~20, lopseed 10~20, myrrh 10~20, caulis trachelospermi 20~30, erythrina bark 10~20, corydalis tuber 20~30, champion bauhinia stem 30~40.Embodiment in the present invention is using Radix Angelicae Pubescentis, turpentine, lycopodium calvatum, windproof, cortex acanthopanacis, the root of Chinese clematis, erythrina bark, champion bauhinia stem as monarch, using Caulis Spatholobi, Rhizoma Chuanxiong, Radix Notoginseng, safflower, corydalis tuber as minister, assistant is with berba aristolochiae mollissimae, lopseed, myrrh, make with caulis trachelospermi, above all taste medicine component compatibilities, science combines, mutually compatible phase is needed and is used, without obvious toxic-side effects, with promoting blood circulation and removing blood stasis, swelling and pain relieving, human synovial muscles and bones of losing blood is enable to conserve, blood vessels channels and collaterals are unobstructed, so that the therapeutic effect of cervical spondylosis is more preferable.
Description
Technical field
The present invention relates to Chinese medicine preparation technical field, more particularly to a kind of Chinese medicine composition for treating cervical spondylosis and its preparation
Method.
Background technology
Cervical spondylosis is impediment syndrome, the so-called numbness of the traditional Chinese medical science, that is, occludes obstructed meaning, and " not general rule pain ".Its principal causative is former
Cause：First, damage；Second is that it is attacked outside exopathogen, predominantly wind, cold, wet；Third, Wei Yang is not solid, opening of sweat pores rushes down or vim and vigour are insufficient or phase
Internal organs is answered to lie concealed the illness reason caused by venereal disease change (each positive unsaturated vapor of internal organs).Its pathomechanism is：It is attacked in damage, exopathogen
Enter, under the insufficient pathogenic factor effect of healthy tendency, lead to stagnation of QI and blood, cause passages through which vital energy circulates qi and blood obstruction not smooth, with muscle, muscles and bones, pass
Section is ached, it is numb, weigh, joint stuffiness is main clinic symptoms.Its Etiological because of Shen controls bone, also has outer excessive in kidney
Leaching is attacked, caused by main long-term drinking eats the cold food of raw food, because kidney is afraid of to tremble with fear.Older more of morbidity crowd, with body
It is immune related.
The common drug for the treatment of cervical spondylosis can be divided into two major class of Western medicine and Chinese medicine at present, wherein, Western medicine has antalgesic, such as
Aspirin, brufen, Fenbid etc.；Adjusting nervous system trophism medicine has vitamin B1, vitamin B12, oryzanol, thorn
Slender acanthopanax piece, brain tonic mixture etc., these Western medicine can play the role for the treatment of pain, but not play effective radical cure effect.
Common Chinese patent drug has rheumatic cold pain piece, blood-nourishing honor muscle piece, GUXIAN PIAN, bony spur tablet, cervicodynia piece, Jingfukang, medicine xiaolingxian neck, neck that must answer
Deng.Common Chinese medicinal formulae has duhuo jisheng decoction, Taohong Siwu Tang, spur soup, stretches muscle blood activating decoction etc., these Chinese patent drugs or prescription
There is certain therapeutic effect to cervical spondylosis, but curative effect is slow, therapeutic effect is not highly satisfactory.
In conclusion at present it is urgent to provide a kind of to treating the Chinese medicine composition that cervical spondylosis curative effect is fast, therapeutic effect is good.
Invention content
The embodiment of the present invention is designed to provide a kind of Chinese medicine composition for treating cervical spondylosis and preparation method thereof so that
The therapeutic effect of cervical spondylosis is more preferable, and curative effect is faster.
In order to solve the above technical problems, the embodiment provides a kind of Chinese medicine composition for treating cervical spondylosis, by
The raw material of following portions by weight is made：Berba aristolochiae mollissimae 10~20, Radix Angelicae Pubescentis 10~20, turpentine 30~40, lycopodium calvatum 10~20, windproof 20
~30, Caulis Spatholobi 9~19, Rhizoma Chuanxiong 30~40, cortex acanthopanacis 10~20, the root of Chinese clematis 10~20, Radix Notoginseng 10~20, safflower 10~20,
Lopseed 10~20, myrrh 10~20, caulis trachelospermi 20~30, erythrina bark 10~20, corydalis tuber 20~30, champion bauhinia stem 30~40.
In addition, the embodiment of the present invention additionally provides a kind of preparation method for treating cervical spondylosis, include the following steps：
S1, each bulk pharmaceutical chemicals are weighed by above-mentioned parts by weight and are mixed；Add the water logging of 8~9 times of weight of material medicine
Bubble, the bulk pharmaceutical chemicals after being impregnated；
S2, the bulk pharmaceutical chemicals after the immersion are decocted to boiling, uses instead and be cooked by slow fire, filtered, obtain first time filtrate
And the dregs of a decoction；
S3, the water that the dregs of a decoction described in S2 are added to 6~8 times of bulk pharmaceutical chemicals again decoct to after boiling, use instead and be cooked by slow fire, mistake
Filter, obtains second of filtrate；
S4, the first time filtrate described in S2 and second of filtrate described in S3 are merged, mixing,.
The embodiment of the present invention is dispelled with Radix Angelicae Pubescentis, turpentine, lycopodium calvatum, windproof, cortex acanthopanacis, the root of Chinese clematis, erythrina bark, champion bauhinia stem except wind
Wet, warming channel and expelling cold, pain-relieving arthralgia dredging is monarch, using Caulis Spatholobi, Rhizoma Chuanxiong, Radix Notoginseng, safflower, corydalis tuber mass dissipating and swelling eliminating, wind-expelling pain-stopping as minister,
Assistant is made with caulis trachelospermi with berba aristolochiae mollissimae, lopseed, myrrh, more than all taste medicine component compatibilities, science combination, mutually compatible phase need and
With, no obvious toxic-side effects, there is promoting blood circulation and removing blood stasis, promoting circulation of blood qi-regulating, sensible active, swelling and pain relieving makes human synovial lose blood muscles and bones
It is conserved, blood vessels channels and collaterals are unobstructed, so that the therapeutic effect of cervical spondylosis is more preferable.
In addition, the Chinese medicine composition for the treatment of cervical spondylosis is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 15~20, solely
Living 15~20, turpentine 25~40, lycopodium calvatum 5~20, windproof 15~30, Caulis Spatholobi 15~19, Rhizoma Chuanxiong 25~40, cortex acanthopanacis 5~
20, the root of Chinese clematis 5~20, Radix Notoginseng 5~20, safflower 5~20, lopseed 5~20, myrrh 5~20, caulis trachelospermi 25~30, erythrina bark 5
~20, corydalis tuber 25~30, champion bauhinia stem 35~40.
In addition, the Chinese medicine composition for the treatment of cervical spondylosis is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 10, Radix Angelicae Pubescentis 10,
Turpentine 30, lycopodium calvatum 10, windproof 20, Caulis Spatholobi 9, Rhizoma Chuanxiong 30, cortex acanthopanacis 10, the root of Chinese clematis 10, Radix Notoginseng 10, safflower 10, lopseed
10, myrrh 10, caulis trachelospermi 20, erythrina bark 10, corydalis tuber 20, champion bauhinia stem 30.
In addition, the Chinese medicine composition is decoction, one kind in tablet, capsule, granule, pill, paste.
In addition, the decocting time in S2 and S3 is 30~50 minutes.
In addition, the decocting time in S2 and S3 is 40 minutes.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, various embodiments of the present invention will be carried out below
Detailed elaboration.However, it will be understood by those skilled in the art that in various embodiments of the present invention, in order to make reader more
The application is understood well and proposes many technical details.But even if without these technical details and based on following implementation
The various changes and modifications of example, can also realize the application technical solution claimed.
Embodiment 1
Chinese medicine composition in the present embodiment is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 10, Radix Angelicae Pubescentis 10, turpentine
30, lycopodium calvatum 10, windproof 20, Caulis Spatholobi 9, Rhizoma Chuanxiong 30, cortex acanthopanacis 10, the root of Chinese clematis 10, Radix Notoginseng 10, safflower 10, lopseed 10 do not have
Medicine 10, caulis trachelospermi 20, erythrina bark 10, corydalis tuber 20, champion bauhinia stem 30.
Each bulk pharmaceutical chemicals in the present embodiment belong to common Chinese medicine, and can be obtained by buying.
Preferably, the Chinese medicine composition in the present embodiment can be decoction, wherein, prepare the method packet of the Chinese medicine composition
Include following steps：
S1, each bulk pharmaceutical chemicals are weighed by above-mentioned parts by weight and are mixed；Add the water logging of 8~9 times of weight of material medicine
Bubble, the bulk pharmaceutical chemicals after being impregnated；
S2, the bulk pharmaceutical chemicals after the immersion are decocted to boiling, uses instead and be cooked by slow fire, filtered, obtain first time filtrate
And the dregs of a decoction；
S3, the water that the dregs of a decoction described in S2 are added to 6~8 times of bulk pharmaceutical chemicals again decoct to after boiling, use instead and be cooked by slow fire, mistake
Filter, obtains second of filtrate；
S4, the first time filtrate described in S2 and second of filtrate described in S3 are merged, mixing,.
Preferably, the decocting time in S2 and S3 can be 40 minutes.
Compared with prior art, the embodiment of the present invention is with Radix Angelicae Pubescentis, turpentine, lycopodium calvatum, windproof, cortex acanthopanacis, the root of Chinese clematis, pittosporum tobira
Skin, champion bauhinia stem eliminate wind and clear damp, warming channel and expelling cold, pain-relieving arthralgia dredging are monarch, are disappeared with Caulis Spatholobi, Rhizoma Chuanxiong, Radix Notoginseng, safflower, corydalis tuber dissipating bind
Swollen, wind-expelling pain-stopping is minister, helps with berba aristolochiae mollissimae, lopseed, myrrh, makes with caulis trachelospermi, more than all taste medicine component compatibilities, science group
It closes, mutually compatible phase is needed and used, no obvious toxic-side effects, has promoting blood circulation and removing blood stasis, promoting circulation of blood qi-regulating, and sensible active, swelling and pain relieving makes
Human synovial muscles and bones of losing blood is conserved, and blood vessels channels and collaterals are unobstructed, so that the therapeutic effect of cervical spondylosis is more preferable.
Embodiment 2
Chinese medicine composition in the present embodiment is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 10, Radix Angelicae Pubescentis 10, turpentine
30, lycopodium calvatum 10, windproof 20, Caulis Spatholobi 9, Rhizoma Chuanxiong 30, cortex acanthopanacis 10, the root of Chinese clematis 10, Radix Notoginseng 10, safflower 10, lopseed 10 do not have
Medicine 10, caulis trachelospermi 20, erythrina bark 10, corydalis tuber 20, champion bauhinia stem 30.
Each bulk pharmaceutical chemicals in the present embodiment belong to common Chinese medicine, and can be obtained by buying.
Preferably, the Chinese medicine composition in the present embodiment can be decoction, wherein, prepare the method packet of the Chinese medicine composition
Include following steps：
S1, each bulk pharmaceutical chemicals are weighed by above-mentioned parts by weight and are mixed；Add the water logging of 8~9 times of weight of material medicine
Bubble, the bulk pharmaceutical chemicals after being impregnated；
S2, the bulk pharmaceutical chemicals after the immersion are decocted to boiling, uses instead and be cooked by slow fire, filtered, obtain first time filtrate
And the dregs of a decoction；
S3, the water that the dregs of a decoction described in S2 are added to 6~8 times of bulk pharmaceutical chemicals again decoct to after boiling, use instead and be cooked by slow fire, mistake
Filter, obtains second of filtrate；
S4, the first time filtrate described in S2 and second of filtrate described in S3 are merged, mixing,.
Preferably, the decocting time in S2 and S3 can be 30 minutes.
Embodiment 3
Chinese medicine composition in the present embodiment is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 10, Radix Angelicae Pubescentis 10, turpentine
30, lycopodium calvatum 10, windproof 20, Caulis Spatholobi 9, Rhizoma Chuanxiong 30, cortex acanthopanacis 10, the root of Chinese clematis 10, Radix Notoginseng 10, safflower 10, lopseed 10 do not have
Medicine 10, caulis trachelospermi 20, erythrina bark 10, corydalis tuber 20, champion bauhinia stem 30.
Each bulk pharmaceutical chemicals in the present embodiment belong to common Chinese medicine, and can be obtained by buying.
Preferably, the Chinese medicine composition in the present embodiment can be decoction, wherein, prepare the method packet of the Chinese medicine composition
Include following steps：
S1, each bulk pharmaceutical chemicals are weighed by above-mentioned parts by weight and are mixed；Add the water logging of 8~9 times of weight of material medicine
Bubble, the bulk pharmaceutical chemicals after being impregnated；
S2, the bulk pharmaceutical chemicals after the immersion are decocted to boiling, uses instead and be cooked by slow fire, filtered, obtain first time filtrate
And the dregs of a decoction；
S3, the water that the dregs of a decoction described in S2 are added to 6~8 times of bulk pharmaceutical chemicals again decoct to after boiling, use instead and be cooked by slow fire, mistake
Filter, obtains second of filtrate；
S4, the first time filtrate described in S2 and second of filtrate described in S3 are merged, mixing,.
Preferably, the decocting time in S2 and S3 can be 50 minutes.
Embodiment 4
Chinese medicine composition in the present embodiment is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 20, Radix Angelicae Pubescentis 20, turpentine
40, lycopodium calvatum 20, windproof 30, Caulis Spatholobi 19, Rhizoma Chuanxiong 40, cortex acanthopanacis 20, the root of Chinese clematis 20, Radix Notoginseng 20, safflower 20, lopseed 20,
Myrrh 20, caulis trachelospermi 30, erythrina bark 20, corydalis tuber 30, champion bauhinia stem 40.
Each bulk pharmaceutical chemicals in the present embodiment belong to common Chinese medicine, and can be obtained by buying.
Preferably, the Chinese medicine composition in the present embodiment can be paste, wherein, prepare the method packet of the Chinese medicine composition
Include following steps：
S1, it each bulk pharmaceutical chemicals is weighed by above-mentioned parts by weight and are mixed is decocted, decocted rear liquid and concentrated,
It is 1 to be concentrated into proportion：1.3 concentration, cooling；
S2, the ethyl alcohol that 2 times are added in into mixture after cooling, are uniformly mixed, stand, make its precipitation；
S3, next day take supernatant；Sediment is merged with filtrate, is recovered under reduced pressure with 60% a small amount of ethyl alcohol wash clean, washing lotion
It after ethyl alcohol, when being concentrated into certain concentration, stands, filtering, filtrate low-temperature evaporation to paste, adds in other auxiliary materials, modulation is equal
It is even, you can be applied on medical adhesive tape to get to the ointment plaster of above-mentioned Chinese medicine composition.
Embodiment 5
Chinese medicine composition in the present embodiment is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 15, Radix Angelicae Pubescentis 15, turpentine
25, lycopodium calvatum 5, windproof 15, Caulis Spatholobi 15, Rhizoma Chuanxiong 25, cortex acanthopanacis 5, the root of Chinese clematis 5, Radix Notoginseng 5, safflower 5, lopseed 5, myrrh 5,
Caulis trachelospermi 25, erythrina bark 5, corydalis tuber 25, champion bauhinia stem 35.
Each bulk pharmaceutical chemicals in the present embodiment belong to common Chinese medicine, and can be obtained by buying.
Preferably, the Chinese medicine composition in the present embodiment can be tablet, wherein, prepare the method packet of the Chinese medicine composition
Include following steps：
S1, each bulk pharmaceutical chemicals are weighed by above-mentioned parts by weight and are mixed, water is added to be decocted；
S2, the liquid after decocting is concentrated, is concentrated into a certain concentration (proportion 1：1 or so), cold rear 2 times of addition is put
Ethyl alcohol, abundant mixing stands overnight, and makes its precipitation；
S3, next day take the supernatant (filtering when necessary) of S2, and sediment is cleaned with a small amount of 60% ethyl alcohol, and washing lotion is closed with filtrate
And after ethyl alcohol is recovered under reduced pressure, it is to be concentrated to a certain concentration when a certain amount of water mixings is added to stand certain time, precipitation is made to filter completely
It crosses；
S4, by the filtrate low-temperature evaporation in S3 to paste, add in suitable auxiliary material in powdered extract powder, after mixing,
It pressurizes into gradually whole to satisfactory granularity, carries out tabletting to get tablet.
Embodiment 6：Clinical trial
1. general information
200 patient with cervical Spondylopathy are chosen, are met《New Chinese medicine treats the guideline of clinical investigations of cervical spondylosis》About
The diagnostic criteria of " cervical spondylosis ".It is randomly divided into two groups, treatment group 100, control group 100, two groups of patient ages, gender, diseases
There are the data such as number of cases, incidence, sign in feelings weight and symptom, are statistically analyzed, there was no significant difference (P>0.05), have
Comparativity.
2. therapeutic rules and medication
The Chinese medicine composition of the decoction dosage form of the embodiment of the present invention 1 is taken by treatment group, three times a day, each taking 200-
300ml, one week is 1 course for the treatment of, counts curative effect after two courses for the treatment of in 2 week of continuous use.Control group takes cervicodynia piece, and (Shandong is bright
Benevolence Fu Ruida pharmaceutical Co. Ltds produce) one time 4,3 times on the one, two weeks 1 courses for the treatment of, 4 week of continuous use, after two courses for the treatment of
Count curative effect.
3. criterion of therapeutical effect
Reference《New Chinese medicine treats the guideline of clinical investigations of cervical spondylosis》Standard, dizziness, cervicodynia and its related disease
Shape all disappears, and does not influence activity and work, and follow-up 3 months is clinical recovery without recurrence；Dizziness, cervicodynia and related symptoms base
This disappearance only has mild in tired or Changes in weather, and functional rehabilitation does not influence daily life or work, is effective；It is dizzy
Dizzy, cervicodynia and its related symptoms and sign make moderate progress, but unstable condition, have recurrence after drug withdrawal, have an impact to heavy work, are
Effectively；Clinical symptoms and sign is unchanged or anti-exacerbation, are invalid.
4. the therapeutic effect of two groups of patient with cervical Spondylopathy compares
Table 1：The therapeutic effect for the treatment of group cervical vertebra patient
Table 2：The therapeutic effect of control group cervical vertebra patient
In addition, by observation, there is adverse reaction without an example in above-mentioned 100 treatment group subjects, therefore the embodiment of the present invention 1
Chinese medicine composition without incompatibility, there is no any side effects.
5. experiment conclusion
Chinese medicine composition component science in the embodiment of the present invention, abundant raw material is cheap, reasonable compatibility, props up mutually
Hold, have effects that promoting blood circulation, tonify the liver and kidney, dispelling wind and eliminating dampness, removing blood stasis and analgesics, can effective for treat cervical spondylosis, curative effect
It is good, and drug safety, high efficiency have practical clinical meaning and very strong practical value up to more than 98%.
Likewise, the Traditional Chinese medicine composition paste and tablet to 4 and 5 gained treatment cervical spondylosis of embodiment have also been made accordingly
The effect of efficacy assessments are tested, result of the test and embodiment 1 evaluation test result is not made to apply herein to state without significant difference.
It will be understood by those skilled in the art that the various embodiments described above are to realize specific embodiments of the present invention, and
In practical applications, can to it, various changes can be made in the form and details, without departing from the spirit and scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating cervical spondylosis, which is characterized in that be made of the raw material of following portions by weight：Berba aristolochiae mollissimae 10
~20, Radix Angelicae Pubescentis 10~20, turpentine 30~40, lycopodium calvatum 10~20, windproof 20~30, Caulis Spatholobi 9~19, Rhizoma Chuanxiong 30~40, five
Add skin 10~20, the root of Chinese clematis 10~20, Radix Notoginseng 10~20, safflower 10~20, lopseed 10~20, myrrh 10~20, caulis trachelospermi
20~30, erythrina bark 10~20, corydalis tuber 20~30, champion bauhinia stem 30~40.
2. the Chinese medicine composition for the treatment of cervical spondylosis according to claim 1, which is characterized in that in the treatment cervical spondylosis
Drug composition is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 15~20, Radix Angelicae Pubescentis 15~20, turpentine 25~40, lycopodium calvatum 5~
20, windproof 15~30, Caulis Spatholobi 15~19, Rhizoma Chuanxiong 25~40, cortex acanthopanacis 5~20, the root of Chinese clematis 5~20, Radix Notoginseng 5~20, safflower 5
~20, lopseed 5~20, myrrh 5~20, caulis trachelospermi 25~30, erythrina bark 5~20, corydalis tuber 25~30, champion bauhinia stem 35~
40。
3. the Chinese medicine composition for the treatment of cervical spondylosis according to claim 1, which is characterized in that in the treatment cervical spondylosis
Drug composition is made of the raw material of following portions by weight：Berba aristolochiae mollissimae 10, Radix Angelicae Pubescentis 10, turpentine 30, lycopodium calvatum 10, windproof 20, chicken blood
Rattan 9, Rhizoma Chuanxiong 30, cortex acanthopanacis 10, the root of Chinese clematis 10, Radix Notoginseng 10, safflower 10, lopseed 10, myrrh 10, caulis trachelospermi 20, erythrina bark 10,
Corydalis tuber 20, champion bauhinia stem 30.
4. the Chinese medicine composition for the treatment of cervical spondylosis according to any one of claims 1 to 3, which is characterized in that the Chinese medicine
Composition is decoction, one kind in tablet, capsule, pill, paste.
5. a kind of preparation method for the Chinese medicine composition for treating cervical spondylosis, which is characterized in that include the following steps：
S1：Each bulk pharmaceutical chemicals are weighed by above-mentioned parts by weight and are mixed；The water of 8~9 times of weight of material medicine is added to impregnate, is obtained
Bulk pharmaceutical chemicals after to immersion；
S2：Bulk pharmaceutical chemicals after the immersion are decocted to boiling, uses instead and is cooked by slow fire, filters, obtains first time filtrate and medicine
Slag；
S3：The dregs of a decoction described in S2 are added to the water of 6~8 times of bulk pharmaceutical chemicals again, decocts to after boiling, uses instead and be cooked by slow fire, filter, obtain
To second of filtrate；
S4：First time filtrate described in S2 and second of filtrate described in S3 are merged, mixing,.
6. preparation method according to claim 5, which is characterized in that the decocting time in the S2 and S3 is 30~50 points
Clock.
7. preparation method according to claim 6, which is characterized in that the decocting time in the S2 and S3 is 40 minutes.
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| CN111569037A (en) * | 2020-06-12 | 2020-08-25 | 甘肃岷州康养医药科技有限公司 | Moxibustion liquid traditional Chinese medicine composition, preparation method and self-heating moxibustion patch |
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Application publication date: 20180622 |