CN115192689B - Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, application and traditional Chinese medicine preparation thereof - Google Patents
Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, application and traditional Chinese medicine preparation thereof Download PDFInfo
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- CN115192689B CN115192689B CN202210995486.1A CN202210995486A CN115192689B CN 115192689 B CN115192689 B CN 115192689B CN 202210995486 A CN202210995486 A CN 202210995486A CN 115192689 B CN115192689 B CN 115192689B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, application and a traditional Chinese medicine preparation thereof, and belongs to the technical field of medicines. A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 3-12 parts of semen strychni, 3-12 parts of radix aconiti, 2-10 parts of rhizoma arisaematis, 2-10 parts of rhizoma pinelliae, 2-10 parts of angelica sinensis, 2-10 parts of cortex acanthopanacis, 3-12 parts of garden balsam stem, 2-10 parts of cinnamon, 3-12 parts of ligusticum wallichii, 1-9 parts of asarum, 2-10 parts of dried ginger, 2-10 parts of safflower, 2-10 parts of eucommia ulmoides, 1-9 parts of rhizoma cibotii and 1-9 parts of radix trichosanthis. The traditional Chinese medicine composition provided by the invention utilizes a traditional Chinese medicine syndrome differentiation method, and based on interaction relations of monarch, minister, assistant and guide among the raw material medicines, the medicine effect is fully exerted, so that pain symptoms of patients with neck, shoulder, waist and leg pain can be relieved or eliminated, and daily activity capacity of the patients is improved.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, application and a traditional Chinese medicine preparation thereof.
Background
Pain in the neck, shoulder, waist and leg is a frequently occurring and common disease and has the characteristic of repeated attack. There are various causes of pain in neck, shoulder, waist and leg, and the clinical symptoms include pain in waist, intermittent claudication, radiation pain in one or both lower limbs, numbness of lower limbs, paresthesia, etc., which are associated with soft tissue injury, soft tissue chronic strain, wind-cold-dampness factor, allergy or immunity, etc.
With the change of life style of people, the incidence rate of neck, shoulder, waist and leg pain tends to rise year by year. According to investigation statistics, 59.1% of the population aged 30-40 in 2000 samples suffer from cervical and lumbar spondylosis; of the 50-60 year old population, 81% are patients; and the incidence rate of people over 60 years old is up to 82%. The disease has high incidence rate, long treatment course and easy recurrence, and the serious pain and long-term dysfunction caused by the disease seriously affect the physical and mental health and the quality of life of patients, so that the disease is effectively prevented and treated as the main task at present.
Western medicine mostly considers that neck, shoulder, waist and leg pain is related to aseptic inflammation, and antipyretic and analgesic medicines such as aspirin, sulindac, nimesulide, acetaminophen, phenylbutazone and the like are orally taken in treatment, and a method of sealing treatment is adopted on local skin of a pain part, so that the symptoms can be temporarily relieved, the symptoms are easy to relapse after healing, and the dependence on the medicines is enhanced. Therefore, the prevention and treatment strategies of the traditional Chinese medicine for the disease are gradually paid attention to.
The traditional Chinese medicine differentiation shows that neck, shoulder, waist and leg pains belong to the category of arthralgia, injury of tendons and bone arthralgia in middle-jiao, internal causes are caused by deficiency of liver and kidney, aged and weak, channels and collaterals are damaged after trauma, qi stagnation and blood stasis and the like, and external causes are caused by invasion of pathogenic wind, cold and dampness. Middle-aged and elderly patients suffer from weakness, long-term work, hypofunction of viscera, deficiency of qi and blood, unconsolidation of defensive exterior, excessive and uneven force due to long-term labor, damage of muscles, ligaments, fascia, joints, etc., and stagnation of collaterals, qi stagnation and blood stasis due to complex pathogenic wind, cold and dampness.
The patent document with publication number CN107095916 discloses an external traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, and a preparation method and a using method thereof, wherein the composition comprises the following components in parts by weight: 70-90 parts of pseudo-ginseng, 25-35 parts of radix aconiti kusnezoffii, 25-35 parts of borneol, 30-40 parts of dipsacus root, 30-40 parts of szechuan lovage rhizome, 15-25 parts of garden balsam stem, 15-25 parts of carpet bugle, 15-25 parts of frankincense, 15-25 parts of myrrh, 55-65 parts of white mustard seed, 65-75 parts of safflower, 35-45 parts of Chinese angelica, 35-45 parts of notopterygium root, 35-45 parts of radix angelicae pubescentis, 35-45 parts of eucommia bark, 35-45 parts of ground beetle, 35-45 parts of leech, 45-55 parts of lycopodium clavatum, 45-55 parts of suberect spatholobus stem and 45-55 parts of rhizoma corydalis. The main curative effect of the external traditional Chinese medicine composition is to eliminate pain feeling, and the curative effect is relatively single. Because the pain of the neck, shoulder, waist and leg can be influenced by different degrees in daily life capacity, the treatment needs to eliminate the pain and improve the daily life capacity of the patient, so that the pain of the neck, shoulder, waist and leg of the patient can be treated at the same time.
Patent document publication No. CN 107397949A discloses an ointment for treating pain in neck, shoulder, waist and leg, which is prepared from notopterygium root, radix angelicae pubescentis, spatholobus stem, ligusticum wallichii, radix paeoniae rubrathe, clematis chinensis, chinese angelica, kudzuvine root, rhizoma atractylodis, radix sileris, achyranthes and cyathula root, radix stephaniae tetrandrae, large-leaf gentian root, drynaria rhizome, rhizoma cibotii, yam rhizome, astragalus root, radix polygoni multiflori, dipsacus root, tortoise plastron, peach kernel, papaya, buck grass, garden balsam stem, safflower, eucommia bark, acanthopanax bark, cassia twig, perilla leaf, radix aconiti, kusnezoff monkshood root, nux vomica, frankincense, myrrh, centipede, scorpion, black snake, earthworm, dragon's blood, costustoot, white mustard seed, rhizoma corydalis, asafetidae, asarum, cinnamon, pseudo-ginseng, catechu, menthol, borneol, camphor, castor bean, orange seed, fructus liquidambaris, hydrochloride tablet, far infrared ceramic powder and the like. The ointment has the advantages of complex raw material medicines, improper compatibility and low treatment efficiency.
In view of this, the present invention has been made.
Disclosure of Invention
The invention aims to solve the technical problem of providing a traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain aiming at the defects of the prior art so as to improve the treatment effect of the neck, shoulder, waist and leg pain.
In order to solve the technical problems, the invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 3-12 parts of semen strychni, 3-12 parts of radix aconiti, 2-10 parts of rhizoma arisaematis, 2-10 parts of rhizoma pinelliae, 2-10 parts of angelica sinensis, 2-10 parts of cortex acanthopanacis, 3-12 parts of garden balsam stem, 2-10 parts of cinnamon, 3-12 parts of ligusticum wallichii, 1-9 parts of asarum, 2-10 parts of dried ginger, 2-10 parts of safflower, 2-10 parts of eucommia ulmoides, 1-9 parts of rhizoma cibotii and 1-9 parts of radix trichosanthis.
Preferably, the traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 6-9 parts of semen strychni, 6-9 parts of radix aconiti, 4-7 parts of rhizoma arisaematis, 4-7 parts of rhizoma pinelliae, 4-7 parts of angelica sinensis, 4-7 parts of cortex acanthopanacis, 6-9 parts of garden balsam stem, 4-7 parts of cinnamon, 6-9 parts of ligusticum wallichii, 3-6 parts of asarum, 4-7 parts of dried ginger, 4-7 parts of safflower, 4-7 parts of eucommia ulmoides, 3-6 parts of rhizoma cibotii and 3-6 parts of radix anisopliae.
Preferably, the traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 7 parts of semen strychni, 7 parts of radix aconiti, 6 parts of rhizoma arisaematis, 6 parts of rhizoma pinelliae, 6 parts of angelica sinensis, 6 parts of cortex acanthopanacis, 8 parts of garden balsam stem, 6 parts of cinnamon, 8 parts of ligusticum wallichii, 5 parts of asarum, 6 parts of dried ginger, 6 parts of safflower, 6 parts of eucommia ulmoides, 5 parts of rhizoma cibotii, and 5 parts of radix trichosanthis.
Preferably, the traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain is prepared by the following method:
step one: weighing the raw materials, adding water, extracting active ingredients by ultrasonic wave, and filtering after extraction to obtain filtrate I;
step two: adding ethanol into the filtrate I, standing, and removing precipitate to obtain filtrate II;
step three: concentrating the filtrate II, and removing ethanol to obtain refined extract.
Preferably, 8-12ml of water is added to each gram of the raw material medicine.
Preferably, the power of the ultrasonic wave is 1000-1500W, and the ultrasonic time is 8-15min.
Preferably, the volume concentration of the ethanol is 90% or more.
Preferably, the Chinese medicinal composition is applied to the preparation of medicaments for treating neck, shoulder, waist and leg pains.
A Chinese medicinal preparation comprises the above Chinese medicinal composition and pharmaceutically acceptable adjuvants.
Preferably, the auxiliary material is one or more than two of vanillyl butyl ether, azone and menthol.
Preferably, the Chinese medicinal preparation is an external preparation.
The basic characteristics of the raw materials used in the invention are as follows:
raw nux vomica: dried mature seed of loguam Strychnos nuxvomica L. Harvesting mature fruits in winter, taking out seeds, and sun drying. Enter liver and spleen meridians. Bitter and warm in nature; it is toxic. The main functions are as follows: activating collaterals and relieving pain, resolving hard mass and detumescence.
Radix Aconiti): is dried mother root of Aconitum carmichaeli Aconitum carmichaeli Debx. Digging in the last ten days of 6 to 8 months, removing the son root, fibrous root and sediment, and sun drying. It enters heart, liver, kidney and spleen meridians. Pungent and bitter in nature and hot; it is toxic. The main functions are as follows: dispelling wind and removing dampness, warming meridians and relieving pain.
Raw rhizoma arisaematis: is a dry tuber of Schott. Collected in autumn and winter when stem and leaf withered, removed fibrous root and crust, and dried. It enters lung, liver and spleen meridians. Bitter and pungent in flavor and warm in nature; is toxic. The main functions are as follows: eliminating dampness and phlegm, dispelling wind and relieving spasm, resolving masses and detumescence.
Raw pinellia ternate: is a dry tuber of the plant Pinellia ternata Pinellia ternata (thunder.) of Araceae. Collected in summer and autumn, cleaned, removed with skin and fibrous root, and sun-dried. Enter spleen, stomach and lung meridians. Sex taste: pungent and warm; is toxic. The main functions are as follows: dry dampness and resolve phlegm, reduce adverse flow of qi and arrest vomiting, relieve distension and fullness and dissipate nodulation.
Chinese angelica root: is the dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels of Umbelliferae. Removing impurities, cleaning, moistening, slicing, sun drying or low temperature drying. It enters liver, heart and spleen meridians. Sex taste: sweet, pungent and warm. The main functions are as follows: replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation.
Cortex Acanthopancis (Acanthopanax senticosus (Rupr. Et Maxim.) harms): is dried root bark of Acanthopanax gracilistylus Acanthopanax gracilistylus W.W.Smith. Root parts of summer and autumn Ji Caiwa are cleaned, root barks are peeled off, and the roots are dried in the sun and enter liver and kidney meridians. Pungent and bitter in flavor and warm in nature. The main functions are as follows: dispelling wind-dampness, nourishing liver and kidney, and strengthening tendons and bones.
Speranskia Tuberculata (L.) Makino: is a whole plant of Euphorbiaceae genus plant Euphorbia lathyris Speranskia tuberculata (Bunge) baill. Xia Qiucai. Processing: cleaning, sun drying, and cutting. It enters liver and kidney meridians. Pungent and bitter in flavor and warm in nature. It is slightly toxic. The main functions are as follows: dispelling wind and removing dampness, and removing toxic substances and relieving pain.
Cinnamon: is dried bark of Cinnamomum cassia Cinnamomum cassia Presl belonging to Lauraceae. Peeling in autumn, and drying in the shade. It enters kidney, spleen, heart and liver meridians. Pungent and sweet in flavor and high in heat. The main functions are as follows: tonifying fire and invigorating yang, inducing fire to enter the source, dispelling cold and relieving pain, and promoting blood circulation and dredging channels.
Ligusticum wallichii: is dried rhizome of Ligusticum chuanxiong Hort Ligusticum chuanxiong Hort (or Ligusticum wallichii Franch.) belonging to Umbelliferae. Processing: removing impurities, separating, soaking, cleaning, moistening, slicing, and drying. Enter liver, gallbladder and pericardium meridians. Pungent and warm in nature. The main functions are as follows: promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain.
Asarum herb: is a dried whole herb of Kitag of Aristolochiaceae plant North asarum Asarum heterotropoides Fr. Processing: removing impurities, spraying clear water, slightly wetting, cutting into segments, and drying in the shade. It enters heart, lung and kidney meridians. Pungent and warm in nature. The main functions are as follows: dispelling wind and cold, inducing resuscitation and relieving pain, warming lung and resolving fluid retention.
Dried ginger: is dried rhizome of ginger Zingiber officinale Rosc. Collected in winter, removed fibrous root and silt, dried in the sun or dried at low temperature. It enters spleen, stomach, kidney, heart and lung meridians. Pungent and hot in nature. The main functions are as follows: warming middle energizer to dispel cold, restoring yang, activating pulse, drying dampness and resolving phlegm.
Safflower: is a dried flower of Compositae plant safflower Carthamus tinctorius L. It enters heart and liver meridians. Pungent and warm in nature. The main functions are as follows: promoting blood circulation, dredging channels, removing blood stasis and relieving pain.
Eucommia ulmoides: is dried bark of eucommia ulmoides Eucommia ulmoides Oliv. It enters liver and kidney meridians. Sweet in nature and warm in nature. The main functions are as follows: liver and kidney tonifying, tendons and bones strengthening, miscarriage preventing.
Rhizoma Cibotii: is dried rhizome of a mussel family plant, cibotium barometz Cibotium barometz (l.) j.sm. It enters liver and kidney meridians. Bitter and sweet in flavor and warm in nature. The main functions are as follows: liver and kidney tonifying, waist and spine strengthening, and wind-damp expelling.
Three parts: is prepared from plant of scopolia of Solanaceae, root, stem and leaf and seed by adding into powder of plant of scopolia of Solanaceae, wherein the plant is Anisodus acutangulus C.Y.wu et C.Chen. Pungent and bitter in flavor and warm in nature. It is toxic. The main functions are as follows: anesthesia and analgesia, wind dispelling and dampness eliminating.
Compared with the prior art, the invention has the following beneficial effects:
1. based on the intensive study on the pathogenesis of neck, shoulder, waist and leg pain, the invention considers that the main external cause causing neck, shoulder, waist and leg pain is wind-cold dampness evil, the main internal cause is qi stagnation and blood stasis, vital qi is insufficient, the basic pathogenesis is invasion of wind-cold dampness evil, and the blockage of channels and qi and blood is caused, and pain is caused, so the treatment takes the main principles of dredging arthralgia and relieving pain, activating blood circulation to remove blood stasis, nourishing liver and tonifying kidney.
2. The traditional Chinese medicine composition accords with the compatibility principle of monarch, minister, assistant and guide, and in the prescription, semen strychni, radix aconiti, rhizoma arisaematis, rhizoma pinelliae, garden balsam stem, asarum and three parts are matched, so that cold dampness is removed, arthralgia is relieved, collaterals are cleared, menstruation is warmed, toxin is removed, stagnation is removed, the channels and collaterals are unblocked, pain of patients is relieved or eliminated, and the traditional Chinese medicine composition is a monarch drug; chinese angelica, cinnamon, ligusticum wallichii, dried ginger and safflower are matched, so that the Chinese angelica root, cinnamon, ligusticum wallichii, dried ginger and safflower are used for promoting blood circulation to remove blood stasis, further promoting qi and blood circulation and improving blood circulation, and are ministerial drugs; cortex acanthopanacis, eucommia ulmoides and rhizoma cibotii are added on the basis of smooth channels and collaterals and qi and blood, and are used as adjuvant drugs for tonifying liver and kidney, strengthening tendons and bones, strengthening healthy qi, enabling pathogenic factors to go out and taking the principal and subordinate symptoms into consideration; the medicines cooperate to realize general pain-free, recovery of health and relapse prevention.
3. The traditional Chinese medicine composition fully exerts the efficacy based on the interaction relationship of monarch, minister, assistant and guide among the raw material medicines by utilizing a traditional Chinese medicine differentiation method, thereby relieving or eliminating the pain symptoms of patients with neck, shoulder, waist and leg pain, reducing the daily life disorder of the patients and improving the daily activity capability of the patients.
4. The traditional Chinese medicine composition is extracted by combining ultrasonic extraction and alcohol precipitation, and a proper ultrasonic extraction process is adopted according to the comprehensive characteristics of the raw materials, preferably the ultrasonic power is 1000-1500W, and the ultrasonic time is 8-15min, so that the tissues of the raw materials are effectively destroyed, the extraction efficiency of the medicinal components is improved, and the action effect of the medicine is enhanced; on the basis of ultrasonic extraction, the invention adopts alcohol precipitation to remove impurities, the alcohol precipitation temperature is preferably below 20 ℃, the volume concentration of the alcohol is above 90 percent, the alcohol precipitation time is above 24 hours, the addition amount of the alcohol is 2-3 times of the volume of the filtrate, under the above conditions, the precipitation speed is moderate, excessive coalescence or bulk precipitation does not occur, and therefore, the components such as protein, polysaccharide and the like in the liquid medicine are more fully removed, the purity of the effective components of the liquid medicine is higher, and the liquid medicine is more favorable for preservation and skin absorption.
5. The traditional Chinese medicine preparation is prepared by adding pharmaceutically acceptable auxiliary materials into a traditional Chinese medicine composition, wherein the auxiliary materials are preferably one or more than two of vanillyl butyl ether, azone and menthol, and 3.5-4.5g, preferably 4g of auxiliary materials are added into every 100ml of refined paste; the auxiliary materials are more preferably a composition of vanillyl butyl ether, azone and menthol, and the mass ratio of the three is 1: (1.5-2.5): (0.8-1.2) to accelerate the absorption of the liquid medicine, promote the local blood circulation and realize more remarkable treatment effect, wherein the vanillyl butyl ether can generate a mild and lasting heat source effect after acting on the skin, and accelerate the local microcirculation; azone is a common skin penetration enhancer for promoting the penetration of the drug effect into the skin of an affected part; menthol has fragrance, and has effects of diminishing inflammation, relieving pain and promoting blood circulation when acting on skin; the three components are cooperated, so that the absorption effect of the skin of an affected part on the liquid medicine can be accelerated, the internal circulation is enhanced, the medicine effect can play a more remarkable role in a shorter time, the medicine utilization is enhanced, and the healing effect is improved.
Detailed Description
For a better understanding of the present invention, the following examples are set forth to further illustrate the invention, but are not to be construed as limiting the invention. In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the present invention. It will be apparent, however, to one skilled in the art that the invention may be practiced without one or more of these details.
In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values.
Unless otherwise indicated, all starting materials are from commercially available products and unless otherwise indicated, they do not contain other components not explicitly indicated except for unavoidable impurities.
Example 1: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 7 parts of semen strychni, 7 parts of radix aconiti, 6 parts of rhizoma arisaematis, 6 parts of rhizoma pinelliae, 6 parts of angelica sinensis, 6 parts of cortex acanthopanacis, 8 parts of garden balsam stem, 6 parts of cinnamon, 8 parts of ligusticum wallichii, 5 parts of asarum, 6 parts of dried ginger, 6 parts of safflower, 6 parts of eucommia ulmoides, 5 parts of rhizoma cibotii, and 5 parts of radix trichosanthis.
Weighing the raw materials in parts by weight, adding water, adding 10ml of water into each gram of raw materials, extracting active ingredients by ultrasonic waves, and filtering with gauze after extracting to obtain filtrate I; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.5 times of the volume of the first filtrate, standing at 20 ℃ for 48 hours, and removing the precipitate to obtain a second filtrate; concentrating the filtrate II at 80deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 1250W and the time is 10min.
The relative density of the fine paste was 1.17.
Example 2: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 6 parts of semen strychni, 6 parts of radix aconiti, 4 parts of rhizoma arisaematis, 4 parts of rhizoma pinelliae, 4 parts of angelica sinensis, 4 parts of cortex acanthopanacis, 6 parts of garden balsam stem, 4 parts of cinnamon, 6 parts of rhizoma ligustici wallichii, 3 parts of asarum, 4 parts of dried ginger, 4 parts of safflower, 4 parts of eucommia ulmoides, 3 parts of rhizoma cibotii and 3 parts of radix trichosanthis.
Weighing the raw materials in parts by weight, adding water, adding 8ml of water into each gram of raw materials, extracting active ingredients by ultrasonic waves, and filtering by gauze after extracting to obtain filtrate I; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2 times of the volume of the first filtrate, standing at 20 ℃ for 48 hours, and removing the precipitate to obtain a second filtrate; concentrating the filtrate II at 75deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 1500W, and the ultrasonic time is 8min.
The relative density of the fine paste was 1.15.
Example 3: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 9 parts of semen strychni, 9 parts of radix aconiti, 5 parts of rhizoma arisaematis, 5 parts of rhizoma pinelliae, 5 parts of angelica sinensis, 5 parts of cortex acanthopanacis, 9 parts of garden balsam stem, 5 parts of cinnamon, 9 parts of ligusticum wallichii, 4 parts of asarum, 5 parts of dried ginger, 5 parts of safflower, 5 parts of eucommia ulmoides, 4 parts of rhizoma cibotii and 4 parts of radix anisodus acutifoliae.
Weighing the raw materials in parts by weight, adding water, adding 9ml of water into each gram of raw materials, extracting active ingredients by ultrasonic waves, and filtering with gauze after extracting to obtain filtrate I; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.3 times of the volume of the first filtrate, standing at 20 ℃ for 32 hours, and removing the precipitate to obtain a second filtrate; concentrating the filtrate II at 80deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 1300W, and the ultrasonic time is 12min.
The relative density of the fine paste was 1.18.
Example 4: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 8 parts of semen strychni, 8 parts of radix aconiti, 7 parts of rhizoma arisaematis, 7 parts of rhizoma pinelliae, 7 parts of angelica sinensis, 7 parts of cortex acanthopanacis, 7 parts of garden balsam stem, 7 parts of cinnamon, 8 parts of ligusticum wallichii, 6 parts of asarum, 7 parts of dried ginger, 7 parts of safflower, 7 parts of eucommia ulmoides, 6 parts of rhizoma cibotii and 6 parts of radix anisopliae.
Weighing the raw materials in parts by weight, adding water, adding 10ml of water into each gram of raw materials, extracting active ingredients by ultrasonic waves, and filtering with gauze after extracting to obtain filtrate I; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.5 times of the volume of the first filtrate, standing at 20 ℃ for 40 hours, and removing the precipitate to obtain a second filtrate; concentrating the filtrate II at 85deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 1000W, and the ultrasonic time is 15min.
The relative density of the fine paste was 1.20.
Example 5: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 3 parts of semen strychni, 3 parts of radix aconiti, 2 parts of rhizoma arisaematis, 2 parts of rhizoma pinelliae, 2 parts of angelica sinensis, 2 parts of cortex acanthopanacis, 2 parts of garden balsam stem, 2 parts of cinnamon, 3 parts of ligusticum wallichii, 1 part of asarum, 2 parts of dried ginger, 2 parts of safflower, 2 parts of eucommia ulmoides, 1 part of rhizoma cibotii and 1 part of radix anisodus acutifoliae.
Weighing the raw materials in parts by weight, adding water, adding 12ml of water into each gram of raw materials, extracting active ingredients by ultrasonic waves, and filtering with gauze after extracting to obtain filtrate I; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 3 times of the volume of the first filtrate, standing at 20 ℃ for 42 hours, and removing the precipitate to obtain a second filtrate; concentrating the filtrate II at 80deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 1400W, and the ultrasonic time is 10min.
The relative density of the fine paste was 1.16.
Example 6: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 4 parts of semen strychni, 4 parts of radix aconiti, 3 parts of rhizoma arisaematis, 3 parts of rhizoma pinelliae, 3 parts of angelica sinensis, 3 parts of cortex acanthopanacis, 3 parts of garden balsam stem, 3 parts of cinnamon, 4 parts of ligusticum wallichii, 2 parts of asarum, 3 parts of dried ginger, 3 parts of safflower, 3 parts of eucommia ulmoides, 2 parts of rhizoma cibotii and 2 parts of radix anisodus acutifoliae.
Weighing the raw materials in parts by weight, adding water, adding 9ml of water into each gram of raw materials, extracting active ingredients by ultrasonic waves, and filtering with gauze after extracting to obtain filtrate I; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2 times of the volume of the first filtrate, standing at 20 ℃ for 24 hours, and removing the precipitate to obtain a second filtrate; concentrating the filtrate II at 80deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 1500W, and the ultrasonic time is 15min.
The relative density of the fine paste was 1.17.
Example 7: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 10 parts of semen strychni, 10 parts of radix aconiti, 8 parts of rhizoma arisaematis, 8 parts of rhizoma pinelliae, 8 parts of angelica sinensis, 8 parts of cortex acanthopanacis, 10 parts of garden balsam stem, 8 parts of cinnamon, 10 parts of ligusticum wallichii, 7 parts of asarum, 8 parts of dried ginger, 8 parts of safflower, 8 parts of eucommia ulmoides, 7 parts of rhizoma cibotii and 7 parts of radix anisodus acutifoliae.
Weighing the raw materials in parts by weight, adding water, adding 10ml of water into each gram of raw materials, extracting active ingredients by ultrasonic waves, and filtering with gauze after extracting to obtain filtrate I; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.6 times of the volume of the first filtrate, standing at 20 ℃ for 30 hours, and removing the precipitate to obtain a second filtrate; concentrating the filtrate II at 80deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 1300W, and the ultrasonic time is 12min.
The relative density of the fine paste was 1.15.
Example 8: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 12 parts of semen strychni, 12 parts of radix aconiti, 10 parts of rhizoma arisaematis, 10 parts of rhizoma pinelliae, 10 parts of angelica sinensis, 10 parts of cortex acanthopanacis, 12 parts of garden balsam stem, 10 parts of cinnamon, 12 parts of ligusticum wallichii, 9 parts of asarum, 10 parts of dried ginger, 10 parts of safflower, 10 parts of eucommia ulmoides, 9 parts of rhizoma cibotii and 9 parts of radix mori.
Weighing the raw materials in parts by weight, adding water, adding 10ml of water into each gram of raw materials, extracting active ingredients by ultrasonic waves, and filtering with gauze after extracting to obtain filtrate I; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.5 times of the volume of the first filtrate, standing at 20 ℃ for 48 hours, and removing the precipitate to obtain a second filtrate; concentrating the filtrate II at 80deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 1200W, and the ultrasonic time is 12min.
The relative density of the fine paste was 1.18.
Example 9: preparation of Chinese medicinal preparation
Providing the refined extract prepared in the example 1, vanillyl butyl ether, azone and menthol, weighing 100ml of the refined extract, adding 1g of vanillyl butyl ether, 2g of azone and 1g of menthol, and uniformly mixing to obtain the preparation.
Example 10: preparation of Chinese medicinal preparation
Providing the refined extract prepared in example 2, vanillyl butyl ether, azone and menthol, weighing 100ml of the refined extract, adding 1g of vanillyl butyl ether, 1.5g of azone and 1.2g of menthol, and mixing uniformly to obtain the preparation.
Example 11: preparation of Chinese medicinal preparation
Providing the refined extract prepared in example 3, vanillyl butyl ether, azone and menthol, weighing 100ml of the refined extract, adding 1g of vanillyl butyl ether, 2.5g of azone and 0.8g of menthol, and uniformly mixing to obtain the preparation.
Example 12: preparation of Chinese medicinal preparation
Providing the refined extract prepared in example 4, vanillyl butyl ether and azone, weighing 100ml of the refined extract, adding 1g of vanillyl butyl ether and 3g of azone, and mixing uniformly to obtain the preparation.
Example 13: preparation of Chinese medicinal preparation
Providing the refined extract prepared in example 5 and azone, weighing 100ml of the refined extract, adding 3.5g of azone, and mixing uniformly to obtain the preparation.
Example 14: preparation of Chinese medicinal preparation
Providing the refined extract prepared in example 6, azone and menthol, weighing 100ml of the refined extract, adding 2.5g azone and 1g menthol, and mixing uniformly to obtain the preparation.
Comparative example 1
Weighing the same raw materials as in example 1, adding water, adding 12ml of water per gram of raw materials, decocting with strong fire (180deg.C) for 30min, filtering with gauze to remove residue, decocting the filtrate with slow fire (100deg.C) for 2 hr, standing, and cooling to obtain refined extract.
The relative density of the fine paste was 1.15.
Comparative example 2
Weighing the same raw materials as in example 1, adding water, adding 15ml of water into each gram of raw materials, extracting active ingredients by ultrasonic wave, and filtering with gauze after extraction to obtain filtrate I; adding 75% ethanol into the filtrate I, wherein the addition amount of the ethanol is 4 times of the volume of the filtrate I, standing at 20 ℃ for 48 hours, and removing the precipitate to obtain filtrate II; concentrating the filtrate II at 80deg.C, and removing ethanol to obtain refined extract.
Wherein the power of the ultrasonic wave is 900W and the time is 20min.
The relative density of the fine paste was 1.16.
Effect case 1: acute toxicity and irritation test of skin
1.1 acute toxicity test of skin: 24 healthy white rabbits are taken, the weight of the healthy white rabbits is 1.8-2.0kg, the male and female rabbits are divided into a complete skin group and a damaged skin group according to the weight at random, and each group is provided with two parallel animals, and each group is provided with 3 animals.
Complete skin group: the hairs on the left side and the right side of the back of the tested rabbit are shaved by scissors and a shaver for about 4cm multiplied by 5cm before the experiment for 24 hours, so that the skin is complete and has no damage.
Broken skin group: the hairs on the left and right sides of the back of the test rabbits were shaved with scissors and a shaver over an area of about 4cm×5cm each 24 hours before the experiment, and after the test area was sterilized, the skin was gently lacerated with a five-bladed knife in the presence of mild bleeding.
2g of the fine paste prepared in example 1 was applied to the skin of a rabbit for 24 hours, and after the completion of the experiment, the remaining test substance was washed with warm water. And observing the systemic toxic manifestations and death conditions of skin, hair, eyes and mucous membrane of the rabbits 1h, 24h, 48h and 72h to 7d after removing the test substances, such as respiration, central nervous system, limb activities and the like.
2g of the Chinese medicinal preparation prepared in example 9 is applied to the skin of a rabbit for 24 hours, and after the experiment is finished, the residual test substance is washed off with warm water. And observing the systemic toxic manifestations and death conditions of skin, hair, eyes and mucous membrane of the rabbits 1h, 24h, 48h and 72h to 7d after removing the test substances, such as respiration, central nervous system, limb activities and the like.
Experimental results: during the observation period 7d, the rabbits move freely, have no abnormality in mental state, appetite and defecation, and have no death. The refined paste prepared in example 1 and the traditional Chinese medicine preparation prepared in example 9 can not cause acute toxic reaction when being externally applied to intact and damaged skin of rabbits.
1.2 acute skin irritation test: 24 healthy white rabbits are taken, the weight of the healthy white rabbits is 1.8-2.0kg, the male and female rabbits are divided into a complete skin group and a damaged skin group according to the weight at random, and each group is provided with two parallel animals, and each group is provided with 3 animals.
Complete skin group: the hairs on the two sides of the spine of the back of the tested rabbit are shaved by scissors and a shaver for about 5cm multiplied by 10cm before the experiment for 24 hours, so that the skin is complete and has no damage.
Broken skin group: the hairs on both sides of the back spine of the test rabbit were shaved with scissors and a shaver over an area of about 5cm×10cm each 24 hours before the experiment, and after the test area was disinfected, the skin was gently lacerated with a five-bladed knife in the presence of mild bleeding.
2g of the fine paste prepared in example 1 was applied to the skin of a rabbit for 5 hours, and after the completion of the experiment, the residual test substance was removed with warm water. And the skin reaction at the application site was observed at 1h, 24h, 48h and 72h after the removal of the test substance.
2g of the Chinese medicinal preparation prepared in example 9 was applied to the skin of a rabbit for 5 hours, and after the completion of the experiment, the residual test substance was removed with warm water. And the skin reaction at the application site was observed at 1h, 24h, 48h and 72h after the removal of the test substance.
Experimental results: the skin of the tested area of the whole skin group has no irritation reaction such as erythema, edema and the like, and has no irritation to the whole skin of the rabbit. The damaged skin group began barely visible erythema and resolved within 12 hours without other irritation reactions such as edema.
Effect case 2: clinical test of the Chinese medicinal composition for treating neck, shoulder, waist and leg pain
1 data and method
1.1 general data 160 patients suffering from neck, shoulder, waist and leg pain, which are treated in 2021, 12, 15, and 2022, 6, 30 days of Nanfu Huakang hospital, were selected and classified into 32 patients in a control group, an observation group 1, an observation group 2, a comparison group 1 and a comparison group 2 by a random digital table method. 17 men and 15 women in the control group, and the ages of 31-62 years. The 1 group was observed for 19 men and 13 women, ages 35-63 years. 18 men and 14 women in group 2 were observed, aged 30-60 years. In contrast to 18 men and 14 women in group 1, ages 32-60 years. The age of 34-61 years was compared with 16 men and 16 women in group 2. The general data of five groups of patients were compared, and the differences were statistically significant (P > 0.05) and comparable.
1.2 inclusion and exclusion criteria
1.2.1 patients with the inclusion of standard (1) have symptoms of stiff waist and back, soreness and discomfort, acupuncture, local tension, hair tightness, hair hardness and the like; (2) the patients all understand this study and sign informed consent.
1.2.2 exclusion criteria (1) incorporation of vital organ dysfunction; (2) there are mental diseases; (3) the study was exited midway.
1.3 method
1.3.1 the patients in the control group receive the Chinese medicine acupuncture treatment, and for the patients with neck pain and shoulder pain, medical staff cross point selection from left to right, including Yangxi, hegu, quchi and Fengchi, the patients are confirmed to have needle feeling and then immediately go out without leaving needle, and the treatment is carried out for 1 time/day; aiming at lumbago patients, medical staff takes lumbago and hip pain acupoints including ring jump, principal middle, yanglingquan, shenshu, chengfujie and Jiexi, and takes out needle immediately after confirming that the patients feel needle without leaving needle, and treats for 1 time/day; aiming at knee pain patients, medical staff takes knee pain points, and immediately takes out the needle without leaving the needle after confirming that the patients feel needle, and treats for 1 time/day.
1.3.2 observing that 1 group of patients receive the treatment of the comprehensive scheme of traditional Chinese medicine, medical staff performs external treatment on the patients on the basis of acupuncture treatment. After the acupuncture is finished, no adverse reaction is observed, and then external treatment is carried out. The prescription of the external treatment is the refined paste prepared in the example 1, and each time, the dosage is 1.5g/100cm 2 The area of the affected part is measured by using the refined paste, the paste is smeared on the affected part, the paste is gently massaged to be absorbed, 3 times a day, 1 treatment course is 10 days, and 2 treatment courses are used.
1.3.3 observing that 2 groups of patients receive the treatment of the comprehensive scheme of traditional Chinese medicine, medical staff performs external treatment on the patients on the basis of acupuncture treatment. After the acupuncture is finished, no adverse reaction is observed, and then external treatment is carried out. The prescription of the external treatment is the traditional Chinese medicine preparation prepared in example 9, and each time is 1.5g/100cm 2 The area of the affected part is measured by using the traditional Chinese medicine preparation, the traditional Chinese medicine preparation is smeared on the affected part, the traditional Chinese medicine preparation is gently massaged to be completely absorbed, 3 times a day, 1 treatment course is 10 days, and 2 treatment courses are used.
1.3.4 contrast 1 group of patients receive the treatment of the comprehensive scheme of traditional Chinese medicine, and medical staff carries out external treatment on the patients on the basis of acupuncture treatment. After the acupuncture is finished, no adverse reaction is observed, and then external treatment is carried out. The prescription of the external treatment is the refined paste prepared in comparative example 1, and each time is 1.5g/100cm 2 The area of the affected part is measured by using the refined paste, the paste is smeared on the affected part, the paste is gently massaged to be completely absorbed, 3 times a day, 1 treatment course is 10 days, and 2 treatment courses are used.
1.3.5 contrast 2 groups of patients receive the treatment of the comprehensive scheme of traditional Chinese medicine, and medical staff performs external treatment on the patients on the basis of acupuncture treatment. After the acupuncture is finished, no adverse reaction is observed, and then external treatment is carried out. The prescription of the external treatment is the refined paste prepared in comparative example 2, and each time, the dosage is 1.5g/100cm 2 The area of the affected part is measured by using the refined paste, the paste is smeared on the affected part, the paste is gently massaged to be completely absorbed, 3 times a day, 1 treatment course is 10 days, and 2 treatment courses are used.
1.4 Observation index and judgment Standard
1.4.1 comparing the therapeutic Effect of two groups of patients
The treatment effect is divided into cure, obvious effect and effective. And (3) healing: pain symptoms disappear, the waist, legs and cervical vertebrae move normally, and no recurrence is seen; the effect is shown: pain symptoms are improved, the movement range of the waist, legs and cervical vertebrae is enlarged, and the movement is slightly limited; the method is effective: pain symptoms are not improved, and the movement of waist, legs and cervical vertebrae is obviously limited. Treatment efficacy= (recovery + efficacy)/total case number x 100%.
1.4.2 comparing VAS scores for two groups of patients
The pain performance of the neck, shoulder, waist and leg before and after treatment is evaluated by a VAS scale, wherein a score of 0 indicates no pain performance, a score of <3 indicates slight pain, a score of 4-6 indicates that the pain has a certain influence on normal learning life, and a score of 7-10 indicates that the pain is intolerable.
1.4.3 comparison of ADL score for two groups of patients
Evaluation by ADL scale, score >60 indicates that the patient's life is basically self-care; a score of 40-60 indicates that the patient needs help in life and has moderate dysfunction; scores <40 indicate that the patient has strong dependence on life and severe dysfunction.
1.5 statistical methods
Statistical analysis was performed using SPSS17.0 statistical software. The measurement data is expressed as mean ± standard deviationRepresenting, using t-test; count data is expressed as a rate (%), χ is used 2 And (5) checking. P (P)<0.05 indicates that the difference is statistically significant.
2 results
2.1 comparison of the therapeutic Effect of two groups of patients
Note that: in comparison with the control group, * p is less than 0.05; in comparison with the group of the comparative example 1, △ p is less than 0.05; in comparison with the comparison of the group 2, ☆ P＜0.05。
from the above results, the treatment efficacy of patients in both group 1 and group 2 was higher than that of the control group, and the differences were statistically significant (P < 0.05); the treatment efficacy of patients in the group 1 and the group 2 is higher than that of patients in the group 1, and the differences have statistical significance (P < 0.05); the treatment efficacy was higher for both the patients in group 1 and group 2 than for the control group 2, and the differences were statistically significant (P < 0.05). The treatment efficiency of the patients in the group 2 is higher than that of the patients in the group 1, which shows that the auxiliary materials used by the invention are favorable for improving the treatment effect of the traditional Chinese medicine composition on neck, shoulder, waist and leg pain.
2.2 VAS score comparison of two groups of patients
Note that: in comparison with the control group, * p is less than 0.05; in comparison with the group of the comparative example 1, △ p is less than 0.05; in comparison with the comparison of the group 2, ☆ P＜0.05。
the difference was statistically significant (P > 0.05) in the VAS score comparison for the five groups of patients prior to treatment.
After treatment, the VAS scores were lower for both the patients in group 1 and group 2 than for the control group, and the differences were statistically significant (P < 0.05); the VAS scores were lower for both the patients in group 1 and group 2 than for the control group 1, the differences were statistically significant (P < 0.05); the VAS scores were lower for both the patients in group 1 and group 2 than for the control group 2, and the differences were statistically significant (P < 0.05). The VAS score of the patients in the group 2 is lower than that of the patients in the group 1, which shows that the auxiliary materials used by the invention are favorable for relieving pain sensation of neck, shoulder, waist and leg pain. The ADL score was lower for the patients in group 1 than for the control group, with no statistical significance (P > 0.05). The ADL score was lower for the control group 2 patients than for the control group, with no statistical significance of the difference (P > 0.05).
2.3 ADL score comparison of two groups of patients
Note that: in comparison with the control group, * p is less than 0.05; in comparison with the group of the comparative example 1, △ p is less than 0.05; in comparison with the comparison of the group 2, ☆ P＜0.05。
prior to treatment, the differences were statistically significant (P > 0.05) in ADL score comparisons for five groups of patients.
After treatment, ADL scores were higher for both the group 1 and group 2 patients than for the control group, and differences were statistically significant (P < 0.05); ADL scores were higher for both group 1 and group 2 patients than for the control group 1, differences were statistically significant (P < 0.05); ADL scores were higher for both group 1 and group 2 patients than for the control group 2, with differences of statistical significance (P < 0.05). ADL scores of the patients in the group 2 are higher than those of the patients in the group 1, which shows that the auxiliary materials used by the invention are beneficial to enhancing the treatment effect of the patients and reducing the normal life disorder of the patients. The ADL score was higher for the patients in group 1 than for the control group, with no statistical significance (P > 0.05). The ADL score was higher for the control group 2 patients than for the control group, with no statistical significance of the difference (P > 0.05).
Discussion 3
Pain in neck, shoulder, waist and leg is a pain symptom, and is manifested in the neck, shoulder, waist and leg parts, the life, work and study of a patient are not greatly influenced in early stage, later-stage diseases are continuously developed, the health and life quality are seriously influenced, the normal social activities of the patient are reduced, the emotion of the patient is lowered due to poor limb movement ability, and the self-confidence is lowered. Paralysis may occur in the patient with serious illness, and the patient loses work capacity, which causes serious burden to society and families. Therefore, the patients with pain in neck, shoulder, waist and leg should pay attention to the early symptoms, and timely treat the pain to ensure early recovery.
Based on the intensive study of the pathogenesis of neck, shoulder, waist and leg pain, the inventor considers that the basic pathogenesis of the disease is invasion of pathogenic wind-cold-dampness, so that the meridian and qi and blood are blocked and pain is not cleared, and the main principle of treatment is to unblock arthralgia, relieve pain, activate blood, remove blood stasis, and tonify liver and kidney. The Chinese medicinal composition is prepared from semen strychni, radix aconiti, rhizoma arisaematis, rhizoma pinelliae, garden balsam stem, asarum and three parts by weight, so as to relieve arthralgia, lead a patient to be in a painless state, dredge channels and collaterals by virtue of medicinal effects, and realize conditioning of the channels and qi and blood states of the patient by dredging qi and blood with the assistance of Chinese angelica, cinnamon, rhizoma ligustici wallichii, dried ginger and safflower. The traditional Chinese medicine comprehensive treatment is implemented on the patients with neck, shoulder, waist and leg pain, pain symptoms can be obviously improved, better treatment effect is achieved, daily activity capacity of the patients is improved, and certain application value is achieved.
Finally, it is noted that the above-mentioned embodiments are merely for illustrating the technical solution of the present invention, and that other modifications and equivalents thereof by those skilled in the art should be included in the scope of the claims of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (6)
1. A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain is characterized in that: the raw material medicaments comprise the following components in part by weight: 3-12 parts of semen strychni, 3-12 parts of radix aconiti, 2-10 parts of rhizoma arisaematis, 2-10 parts of rhizoma pinelliae, 2-10 parts of angelica sinensis, 2-10 parts of cortex acanthopanacis, 3-12 parts of garden balsam stem, 2-10 parts of cinnamon, 3-12 parts of ligusticum wallichii, 1-9 parts of asarum, 2-10 parts of dried ginger, 2-10 parts of safflower, 2-10 parts of eucommia ulmoides, 1-9 parts of rhizoma cibotii and 1-9 parts of radix trichosanthis;
the traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain is prepared by the following method:
step one: weighing the raw materials, adding water, extracting active ingredients by ultrasonic wave, and filtering after extraction to obtain filtrate I;
step two: adding ethanol into the filtrate I, standing, and removing precipitate to obtain filtrate II;
step three: concentrating the filtrate II, and removing ethanol to obtain refined paste;
adding 8-12ml of water into each gram of the raw material medicine; the power of the ultrasonic wave is 1000-1500W, and the ultrasonic time is 8-15min; the volume concentration of the ethanol is more than 90 percent.
2. The traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain according to claim 1, which is characterized in that: the raw material medicaments comprise the following components in part by weight: 6-9 parts of semen strychni, 6-9 parts of radix aconiti, 4-7 parts of rhizoma arisaematis, 4-7 parts of rhizoma pinelliae, 4-7 parts of angelica sinensis, 4-7 parts of cortex acanthopanacis, 6-9 parts of garden balsam stem, 4-7 parts of cinnamon, 6-9 parts of ligusticum wallichii, 3-6 parts of asarum, 4-7 parts of dried ginger, 4-7 parts of safflower, 4-7 parts of eucommia ulmoides, 3-6 parts of rhizoma cibotii and 3-6 parts of radix anisopliae.
3. The traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain according to claim 2, which is characterized in that: the raw material medicaments comprise the following components in part by weight: 7 parts of semen strychni, 7 parts of radix aconiti, 6 parts of rhizoma arisaematis, 6 parts of rhizoma pinelliae, 6 parts of angelica sinensis, 6 parts of cortex acanthopanacis, 8 parts of garden balsam stem, 6 parts of cinnamon, 8 parts of ligusticum wallichii, 5 parts of asarum, 6 parts of dried ginger, 6 parts of safflower, 6 parts of eucommia ulmoides, 5 parts of rhizoma cibotii, and 5 parts of radix trichosanthis.
4. Use of a Chinese medicinal composition for treating neck-shoulder-waist-leg pain according to any one of claims 1-3 in the preparation of a medicament for treating neck-shoulder-waist-leg pain.
5. A Chinese medicinal preparation comprising the Chinese medicinal composition according to any one of claims 1-3 and pharmaceutically acceptable excipients.
6. The traditional Chinese medicine preparation according to claim 5, wherein: the auxiliary materials are one or more than two of vanillyl butyl ether, azone and menthol.
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| CN107095916A (en) * | 2017-07-02 | 2017-08-29 | 陈首名 | Treat external medicine composition of neck-shoulder pain, lumbago and leg pain and preparation method thereof and application method |
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| CN109908245A (en) * | 2019-04-28 | 2019-06-21 | 宋少军 | It is a kind of for treating the Chinese medicine composition of neck-shoulder pain, lumbago and leg pain disease |
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| CN107095916A (en) * | 2017-07-02 | 2017-08-29 | 陈首名 | Treat external medicine composition of neck-shoulder pain, lumbago and leg pain and preparation method thereof and application method |
| CN107397949A (en) * | 2017-07-15 | 2017-11-28 | 长沙天卓生物科技有限公司 | A kind of ointment for treating neck-shoulder pain, lumbago and leg pain and preparation method thereof |
| CN108670811A (en) * | 2018-05-22 | 2018-10-19 | 河南华冠新能源科技有限公司 | Quantum spontaneous heating mild moxibustion physiotherapy slice prescription and preparation method thereof |
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