CN110538279B - External traditional Chinese medicine and preparation method thereof - Google Patents
External traditional Chinese medicine and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine external medicine and a preparation method thereof, wherein the traditional Chinese medicine external medicine is composed of traditional Chinese medicine components and alcohol according to the weight ratio of 1:8-12, and the traditional Chinese medicine components comprise: 80-120 parts of safflower, 80-120 parts of borneol, 400 parts of Szechuan lovage rhizome, 150 parts of Chinese angelica, 150 parts of antler and 150 parts of pseudo-ginseng. The traditional Chinese medicine external medicine has the effects of activating blood circulation to dissipate blood stasis, relieving swelling and pain, and having better treatment effects on blood stasis swelling and pain, muscle soreness and rheumatism pain caused by new injuries and old injuries of traumatic injuries.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine external-use medicine and a preparation method thereof.
Background
Traumatic injury mainly refers to soft tissue injury, traumatic swelling and pain, skin and flesh damage and bleeding caused by traumatic injury, pounding and the like, and also includes traumatic gold-cut wound and the like. From the perspective of traditional Chinese medicine, injuries of bones and muscles, swelling and pain due to blood stasis, disharmony between qi and blood, and impairment of organs due to meridian obstruction caused by external force acting on human body are collectively called traumatic injuries. The main pathologies are stasis and blood stasis, blood block and qi block, so pain and swelling are the main manifestations.
The existing external traditional Chinese medicines for treating traumatic injuries are more, but most of the traditional Chinese medicines are complex in raw material components and slow in effect taking, have prominent performance in treating new injuries and are not ideal in treating old injuries and injuries of the traumatic injuries. Traumatic injury old injury generally refers to traumatic injury of more than 3 months, which is mostly caused by new injury, improper treatment and long-term delay.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a traditional Chinese medicine external-use medicine and a preparation method thereof. The traditional Chinese medicine external medicine has the effects of activating blood circulation to dissipate blood stasis, relieving swelling and pain, and having better treatment effects on blood stasis swelling and pain, muscle soreness and rheumatism pain caused by new injuries and old injuries of traumatic injuries.
The technical scheme of the invention is as follows:
a traditional Chinese medicine external medicine is composed of traditional Chinese medicine components and alcohol according to a weight ratio of 1:8-12, wherein the traditional Chinese medicine components comprise: 80-120 parts of safflower, 80-120 parts of borneol, 400 parts of Szechuan lovage rhizome, 150 parts of Chinese angelica, 150 parts of antler and 150 parts of pseudo-ginseng.
Preferably, the traditional Chinese medicine components comprise: 100 parts of safflower, 100 parts of borneol, 500 parts of szechuan lovage rhizome, 200 parts of Chinese angelica, 200 parts of antler and 125 parts of pseudo-ginseng.
Preferably, the antler is a fresh whole antler, and the alcohol is 95-degree medical alcohol.
A method for preparing the traditional Chinese medicine composition comprises the following steps:
(1) washing and weighing antler, preparing antler slices, adding 0.5-1wt% of sodium bicarbonate solution into the antler slices, soaking, washing with water, steaming, adding alcohol into the steamed antler slices, and wet-grinding to obtain a traditional Chinese medicine preparation solution;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, and Notoginseng radix, adding 70-90wt% ethanol into rhizoma Ligustici Chuanxiong, and reflux extracting to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis, and Notoginseng radix, decocting in water, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution in sequence, soaking, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Preferably, the traditional Chinese medicine components further comprise: 15-25 parts of white mustard seed, 5-10 parts of pepper, 10-20 parts of edelweiss and 20-40 parts of bran.
Preferably, the traditional Chinese medicine components further comprise: 20 parts of white mustard seed, 7 parts of pepper, 15 parts of edelweiss and 30 parts of bran.
A method for preparing the traditional Chinese medicine composition comprises the following steps:
(1) washing and weighing antler, preparing antler slices, adding 0.5-1wt% of sodium bicarbonate solution into the antler slices, soaking, washing with water, steaming, adding alcohol into the steamed antler slices, and wet-grinding to obtain a traditional Chinese medicine preparation solution;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 70-90wt% ethanol into rhizoma Ligustici Chuanxiong, and reflux extracting to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, decocting in water, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution in sequence, soaking, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Preferably, in the step (1), the soaking time is 4-8h, the steaming time is 1-1.5h, and the wet grinding is carried out until the solid particle size is 40-80 μm.
Preferably, in the step (2), the volume ratio of the mass of the ligusticum wallichii to the ethanol is 1g:5-10ml, and the reflux extraction time is 60-80 min; the weight ratio of the mixed traditional Chinese medicines to water is 1:6-8, the decoction is carried out by boiling with strong fire and then decocting with slow fire, and the decoction time is 25-40 min.
Preferably, in the step (3), the soaking time is 90-120 days.
In order to facilitate understanding of the present invention, the raw material drugs and the drug effects of the present invention will now be further described.
Safflower, pungent in flavor and warm in nature. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain.
Chuan Xiong is pungent in flavor and warm in nature. Promote blood circulation and move qi, dispel wind and alleviate pain. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, thoracic rib stabbing pain, traumatic injury, swelling and pain, headache, and rheumatalgia.
Dang Gui is sweet and pungent in flavor and warm in nature. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Notoginseng, sweet in taste, slightly bitter in flavor and warm in nature. Disperse blood stasis, stop bleeding, resolve swelling and alleviate pain. Can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain.
Antler, sweet in taste, salty in flavor and warm in nature. Warming kidney yang, strengthening tendons and bones, promoting blood circulation and relieving swelling. Can be used for treating sexual impotence, spermatorrhea, lumbago, cold pain of spine, carbuncle of yin nature, pyocutaneous disease, acute mastitis, and swelling and pain due to blood stasis.
Borneol, pungent and bitter in flavor and slightly cold in nature. Induce resuscitation and refresh mind, clear heat and alleviate pain. Can be used for treating coma, sore throat, and aphtha of the mouth and tongue.
White mustard seed, pungent in flavor and warm in nature. Warming lung and eliminating phlegm, promoting qi and resolving hard mass, and dredging collaterals and relieving pain. Can be used for treating cough and asthma due to cold phlegm, fullness in chest and hypochondrium, deep rooted carbuncle of yin type, multiple abscess, numbness of limbs, and pain.
Pepper, pungent in flavor and hot in nature. Warming middle energizer to dispel cold, invigorating stomach and relieving pain. Can be used for treating deficiency-cold of spleen and stomach, abdominal psychroalgia, anorexia, and gastric cavity pain.
Ma Cao is pungent in flavor and warm in nature. Orally taken to promote vomiting, prop bones and remove stealing. Externally used to stop bleeding, alleviate pain and dredge orifices. For traumatic injury, it is ground into powder and taken with wine; nasal obstruction, nervous toothache, powder for nasal insufflation; for traumatic hemorrhage, grind into powder and mix with others.
Bran, sweet in taste, cold in nature. Improving constipation and preventing colon cancer. It can be used for treating sweating, night sweat, diarrhea, diabetes, stomatitis, heat sore, fracture, rheumatalgia, and tinea pedis.
The invention has the beneficial effects that:
1. the traditional Chinese medicine external medicine disclosed by the invention is prepared by taking the safflower, the borneol, the ligusticum wallichii, the angelica sinensis, the antler and the pseudo-ginseng as raw materials and carrying out proper weight proportion, wherein the ligusticum wallichii is used for activating blood and promoting qi circulation, dispelling wind and relieving pain and is a monarch drug, the angelica sinensis is used for enhancing the effects of activating blood and relieving pain of the ligusticum wallichii and is a ministerial drug, the safflower is used for dissipating blood stasis, the borneol is used for clearing heat, the antler is used for reducing swelling, and the pseudo-ginseng is used for stopping bleeding, and the four drugs are used as adjuvant drugs to assist the monarch drug and the ministerial drug in enhancing the curative effect from multiple aspects. The finally prepared traditional Chinese medicine for external use has the effects of activating blood circulation to dissipate blood stasis, relieving swelling and pain, and having better treatment effects on blood stasis swelling and pain, muscle soreness and rheumatism pain caused by traumatic injury.
2. The traditional Chinese medicine external medicine comprises 15-25 parts by weight of white mustard seed, 5-10 parts by weight of pepper, 10-20 parts by weight of edelweiss and 20-40 parts by weight of bran. The reason is that through a large number of experimental researches, the inventor discovers that the medicines are compatible with the safflower, the borneol, the ligusticum wallichii, the angelica sinensis, the antler and the pseudo-ginseng, and compared with other medicines, the medicine has a better synergistic effect, and can further improve the treatment effect of the medicine on relieving ecchymosis caused by traumatic injury.
3. According to the preparation method of the traditional Chinese medicine external medicine, the antler and the traditional Chinese medicine components are subjected to special treatment, so that the finally prepared medicine has a better treatment effect in the aspect of treating new injuries and old injuries of traumatic injuries compared with the prior art.
Detailed Description
The present invention is further illustrated by the following specific examples.
In the following examples, 1 part by weight represents 1 g.
Example 1
The embodiment provides a traditional Chinese medicine external medicine which is composed of traditional Chinese medicine components and 95-degree medical alcohol according to the weight ratio of 1:8, wherein the traditional Chinese medicine components comprise: 80 parts of safflower, 80 parts of borneol, 400 parts of szechuan lovage rhizome, 150 parts of Chinese angelica, 150 parts of antler and 100 parts of pseudo-ginseng.
Further, a method for preparing the traditional Chinese medicine external medicine is provided, which comprises the following steps:
(1) washing cornu Cervi, processing into slices, adding 0.5 wt% sodium bicarbonate solution, soaking for 4 hr, washing with water for 3 times, steaming for 1 hr, cooling to room temperature, adding 95 ° medical ethanol, and wet-grinding to obtain solid substance with particle size of 40 μm to obtain Chinese medicinal liquid;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, and Notoginseng radix, adding 70 wt% ethanol (1 g:5ml) into rhizoma Ligustici Chuanxiong, reflux extracting for 60min to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis and Notoginseng radix, adding 6 times of water, boiling with strong fire, decocting with slow fire for 25min, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution, soaking for 90 days, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Example 2
The embodiment provides a traditional Chinese medicine external medicine which is composed of traditional Chinese medicine components and 95-degree medical alcohol according to the weight ratio of 1:12, wherein the traditional Chinese medicine components comprise: 120 parts of safflower, 120 parts of borneol, 600 parts of szechuan lovage rhizome, 250 parts of Chinese angelica, 250 parts of antler and 150 parts of pseudo-ginseng.
Further, a method for preparing the traditional Chinese medicine external medicine is provided, which comprises the following steps:
(1) washing cornu Cervi, processing into slices, adding 1wt% sodium bicarbonate solution, soaking for 8 hr, washing with water for 4 times, steaming for 1.5 hr, cooling to room temperature, adding 95 ° medical ethanol, and wet-grinding to obtain solid substance with particle size of 80 μm to obtain Chinese medicinal preparation solution;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, and Notoginseng radix, adding 90wt% ethanol (1 g:10ml) into rhizoma Ligustici Chuanxiong, reflux extracting for 80min to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis and Notoginseng radix, adding 8 times of water, boiling with strong fire, decocting with slow fire for 40min, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution, soaking for 120 days, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Example 3
The embodiment provides a traditional Chinese medicine external medicine which is composed of traditional Chinese medicine components and 95-degree medical alcohol according to the weight ratio of 1:10, wherein the traditional Chinese medicine components comprise: 100 parts of safflower, 100 parts of borneol, 500 parts of szechuan lovage rhizome, 200 parts of Chinese angelica, 200 parts of antler and 125 parts of pseudo-ginseng.
Further, a method for preparing the traditional Chinese medicine external medicine is provided, which comprises the following steps:
(1) washing cornu Cervi, processing into slices, adding 1.5 wt% sodium bicarbonate solution, soaking for 5 hr, washing with water for 3 times, steaming for 1.2 hr, cooling to room temperature, adding 95 ° medical ethanol, and wet-grinding to obtain solid substance with particle diameter of 60 μm to obtain Chinese medicinal liquid;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, and Notoginseng radix, adding 80 wt% ethanol (1 g:10ml) into rhizoma Ligustici Chuanxiong, reflux extracting for 70min to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis, and Notoginseng radix, adding 7 times of water, boiling with strong fire, decocting with slow fire for 30min, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution, soaking for 100 days, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Example 4
The embodiment provides a traditional Chinese medicine external medicine which is composed of traditional Chinese medicine components and 95-degree medical alcohol according to the weight ratio of 1:10, wherein the traditional Chinese medicine components comprise: 115 parts of safflower, 90 parts of borneol, 560 parts of szechuan lovage rhizome, 220 parts of Chinese angelica, 210 parts of antler, 130 parts of pseudo-ginseng, 15 parts of white mustard seed, 5 parts of pepper, 10 parts of edelweiss and 20 parts of bran.
Further, a method for preparing the traditional Chinese medicine external medicine is provided, which comprises the following steps:
(1) washing cornu Cervi, processing into slices, adding 1.5 wt% sodium bicarbonate solution, soaking for 6 hr, washing with water for 3 times, steaming for 1 hr, cooling to room temperature, adding 95 ° medical ethanol, and wet-grinding to obtain solid substance with particle diameter of 60 μm to obtain Chinese medicinal liquid;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 80 wt% ethanol (1 g:10ml) into rhizoma Ligustici Chuanxiong, reflux extracting for 70min to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 7 times of water, boiling with strong fire, decocting with slow fire for 30min, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution, soaking for 100 days, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Example 5
The embodiment provides a traditional Chinese medicine external medicine which is composed of traditional Chinese medicine components and alcohol according to the weight ratio of 1:10, wherein the traditional Chinese medicine components comprise: 90 parts of safflower, 90 parts of borneol, 450 parts of szechuan lovage rhizome, 180 parts of Chinese angelica, 200 parts of antler, 120 parts of pseudo-ginseng, 25 parts of white mustard seed, 10 parts of pepper, 20 parts of edelweiss and 40 parts of bran.
Further, a method for preparing the traditional Chinese medicine external medicine is provided, which comprises the following steps:
(1) washing cornu Cervi, processing into slices, adding 1.5 wt% sodium bicarbonate solution, soaking for 6 hr, washing with water for 3 times, steaming for 1 hr, cooling to room temperature, adding 95 ° medical ethanol, and wet-grinding to obtain solid substance with particle diameter of 60 μm to obtain Chinese medicinal liquid;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 80 wt% ethanol (1 g:10ml) into rhizoma Ligustici Chuanxiong, reflux extracting for 70min to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 7 times of water, boiling with strong fire, decocting with slow fire for 30min, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution, soaking for 116 days, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Example 6
The embodiment provides a traditional Chinese medicine external medicine which is composed of traditional Chinese medicine components and alcohol according to the weight ratio of 1:10, wherein the traditional Chinese medicine components comprise: 100 parts of safflower, 100 parts of borneol, 500 parts of szechuan lovage rhizome, 200 parts of Chinese angelica, 200 parts of antler, 125 parts of pseudo-ginseng, 20 parts of white mustard seed, 7 parts of pepper, 15 parts of edelweiss and 30 parts of bran.
Further, a method for preparing the traditional Chinese medicine external medicine is provided, which comprises the following steps:
(1) washing cornu Cervi, processing into slices, adding 1.5 wt% sodium bicarbonate solution, soaking for 6 hr, washing with water for 3 times, steaming for 1 hr, cooling to room temperature, adding 95 ° medical ethanol, and wet-grinding to obtain solid substance with particle diameter of 60 μm to obtain Chinese medicinal liquid;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 80 wt% ethanol (1 g:10ml) into rhizoma Ligustici Chuanxiong, reflux extracting for 70min to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 7 times of water, boiling with strong fire, decocting with slow fire for 30min, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution, soaking for 110 days, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Comparative example 1
The same raw material composition as in example 6, except for the difference in the step (1) in the preparation method, the specific preparation method is as follows:
(1) cleaning and drying cornu Cervi, filing into coarse powder, then finely pulverizing to particle size of 60 μm, then adding 95 ° medical alcohol, and stirring well to obtain Chinese medicinal preparation solution;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 80 wt% ethanol (1 g:10ml) into rhizoma Ligustici Chuanxiong, reflux extracting for 70min to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 7 times of water, boiling with strong fire, decocting with slow fire for 30min, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding borneol powder and mixed traditional Chinese medicine extraction powder into the traditional Chinese medicine preparation solution, soaking for 100 days, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Comparative example 2
The same raw material composition as that of example 6, except for the difference in the step (2) in the preparation method, the specific preparation method is as follows:
(1) washing cornu Cervi, processing into slices, adding 1.5 wt% sodium bicarbonate solution, soaking for 6 hr, washing with water for 3 times, steaming for 1 hr, cooling to room temperature, adding 95 ° medical ethanol, and wet-grinding to obtain solid substance with particle diameter of 60 μm to obtain Chinese medicinal liquid;
(2) weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici respectively, mixing, adding 7 times of water, boiling with strong fire, decocting with slow fire for 30min, filtering to remove residue to obtain extractive solution, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding borneol powder and mixed traditional Chinese medicine powder into the traditional Chinese medicine preparation solution, soaking for 100 days, and filtering to obtain filtrate, namely the traditional Chinese medicine external-use medicine.
Examples of the experiments
1. Experimental study on treatment effect of drug on acute soft tissue contusion of rat
1.1 Experimental animals: half of SD rats are female and male, the weight of each SD rat is 200 +/-20 g, the SD rats are averagely divided into 5 groups, and each group is 8, and the SD rats are respectively a negative control group, a test group 1, a test group 2, a test group 3 and a positive control group.
1.2 experiment modeling: the hair of the right rear calf part of each group of rats is removed before the experiment, and the weight smashing method is adopted to cause the acute soft tissue contusion of the right rear calf part of each group of rats.
1.3 administration mode: after 24h, the administration is started, the negative control group, the test group 1, the test group 2, the test group 3 and the positive control group are respectively administered with physiological saline, the medicament of the invention in the embodiment 6, the medicament of the comparative example 1, the medicament of the comparative example 2 and the Yunnan white powder spray to be smeared on the affected part, the administration is continuously carried out for 7 days and 3 times per day, the swelling, the ecchymosis and the walking condition of the contusion part are observed every day, meanwhile, 2 rats are randomly taken out in each group 1, 3 and 7 days after the administration, the rats are killed, the muscle tissues of the affected part are taken, the rats are rinsed with the physiological saline, fixed by formaldehyde solution, stained, and then the degranulation rate of mast cells is evaluated.
1.4 Experimental results: the scoring standards and results of the swelling, ecchymosis and walking conditions of the contused wound are shown in tables 1-2, and the results of the degranulation rate (%) of mast cells are shown in table 3.
TABLE 1 Scoring standards
| Scoring criteria | Score value |
| Slight red swelling, no ecchymosis and walking disorder | 1 minute (1) |
| Slight red swelling and ecchymosis, no walking disorder | 2 is divided into |
| Obvious red swelling and ecchymosis with walking disorder | 3 points of |
| Severe red swelling and ecchymosis, inability to walk | 4 is divided into |
TABLE 2 results of the evaluation of swelling, ecchymosis and walking conditions at the bruises
| Group of | 1 day | 3 days | 7 days |
| Negative control group | 3.59±0.57 | 3.87±0.82 | 3.13±0.76 |
| Test group 1 | 3.26±0.41 | 2.35±0.74*# | 1.16±0.32*# |
| Test group 2 | 3.45±0.37 | 2.65±0.71 | 1.74±0.45 |
| Test group 3 | 3.37±0.29 | 2.46±0.65 | 1.37±0.51 |
| Positive control group | 3.47±0.46 | 2.73±0.69 | 1.82±0.57 |
TABLE 3 mast cell degranulation (%) comparison of results
| Group of | 1 day | 3 days | 7 days |
| Negative control group | 84.56±12.04 | 51.59±10.96 | 31.82±8.17 |
| Test group 1 | 47.75±9.66 | 35.11±6.74**# | 15.59±5.06**# |
| Test group 2 | 51.22±9.45 | 39.27±7.81 | 21.64±7.39 |
| Test group 3 | 50.39±7.83 | 38.74±6.96 | 19.36±6.52 |
| Positive control group | 53.26±9.39 | 40.32±10.03 | 23.87±8.33 |
P <0.05 compared to the negative control group, p <0.01 compared to the positive control group, p < 0.05.
The results show that after the model building is successful, the swelling, ecchymosis and walking condition of the contused wound of the rats in the negative control group are firstly aggravated and then gradually relieved along with the time course, each test group and the positive control group show a descending trend, and the histological observation results show that the degranulation rate of mast cells in local contused tissues is obviously increased after the contused wound and shows a descending trend along with the time course. On days 3 and 7 after contusion, compared with each control group, the results of scoring the swelling, ecchymosis and walking condition of the contusion part of the test group 1 are significantly different; on the 3 rd day and the 7 th day after contusion, the mast cell degranulation rate of the test group 1 is very different from that of the negative control group, and is also different from that of the positive control group, and by combining the results, the treatment effect of the invention is better than that of the comparative example 1, the comparative example 2, the comparative example 3 and the positive control group, thereby further proving that the invention has exact treatment effect on the aspect of treating traumatic injury.
2. Population test study
2.1 test population selection and grouping: 73 patients with soft tissue injury were randomly selected, among 14 males, 18 females, 16 females at the minimum age, 52 females at the maximum age, 36.2 average ages, 42 patients with new injuries (wounds caused within 1 month) and 31 patients with old injuries (wounds caused 3 months ago), all the patients were randomly divided into a test group and a control group, and the test group and the control group were applied to the affected part with the external traditional Chinese medicine of the present invention (sample of example 6) and safflower oil, 3 times a day and continuously used for 3 days.
2.2 the test subjects selected criteria: the clinical manifestations of soft tissue injury caused by external force such as falling, beating, knocking, bumping and the like are pain, swelling, bleeding and ecchymosis at the injury site.
2.3 evaluation criteria
And (3) healing: discomfort symptoms of the affected part completely disappear, and the affected part has open wounds and the wounds are completely healed;
the effect is shown: discomfort symptoms of the affected part are obviously relieved, and the wound is obviously convergent due to the open wound;
the method has the following advantages: the discomfort symptoms of the affected part are relieved;
and (4) invalidation: has no obvious change from before treatment.
2.4 statistics of test results: see table 4.
TABLE 4 comparison of the overall use of each group
The results show that the total effective rates of the medicines in the test group for treating new injuries and old injuries are respectively 90.9 percent and 75 percent, and the total effective rates of the medicines in the control group for treating new injuries and old injuries are respectively 85 percent and 46.7 percent, so that the effect of the medicines in the test group for treating new injuries is better than that of the control group, and the effect of the medicines in the control group for treating old injuries is obviously better than that of the control group, which shows that the medicines in the test group for treating new injuries and old injuries have obvious effects and obvious effects for treating old injuries.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (5)
1. A traditional Chinese medicine external medicine for treating soft tissue injury is characterized by comprising traditional Chinese medicine components and alcohol according to a weight ratio of 1:8-12, wherein the traditional Chinese medicine components comprise the following raw materials: 80-120 parts of safflower, 80-120 parts of borneol, 400 parts of szechuan lovage rhizome, 150 parts of angelica, 150 parts of antler, 100 parts of pseudo-ginseng, 15-25 parts of white mustard seed, 5-10 parts of pepper, 10-20 parts of edelweiss and 20-40 parts of bran;
the preparation method of the traditional Chinese medicine components comprises the following steps:
(1) washing and weighing antler, preparing antler slices, adding 0.5-1wt% of sodium bicarbonate solution into the antler slices, soaking, washing with water, steaming, adding alcohol into the steamed antler slices, and wet-grinding to obtain a traditional Chinese medicine preparation solution;
(2) respectively weighing Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, adding 70-90wt% ethanol into rhizoma Ligustici Chuanxiong, and reflux extracting to obtain extractive solution A; mixing Carthami flos, radix Angelicae sinensis, Notoginseng radix, semen Sinapis Albae, fructus Piperis, herba Thalictri Elati and testa Tritici, decocting in water, filtering to remove residue to obtain extractive solution B; mixing the extractive solution A and B, concentrating, and drying to obtain mixed Chinese medicinal extract powder;
(3) pulverizing Borneolum Syntheticum at low temperature to obtain Borneolum Syntheticum powder; sequentially adding Borneolum Syntheticum powder and mixed Chinese medicinal extract powder into the Chinese medicinal preparation solution, soaking, and filtering.
2. The external traditional Chinese medicine for treating soft tissue injury according to claim 1, wherein the antler is a fresh whole antler, and the alcohol is 95 ° medical alcohol.
3. The traditional Chinese medicine external medicine for treating soft tissue injury according to claim 1, wherein in the step (1), the soaking time is 4-8h, the steaming time is 1-1.5h, and the wet grinding is carried out until the solid particle size is 40-80 μm.
4. The external traditional Chinese medicine for treating soft tissue injury according to claim 1, wherein in the step (2), the volume ratio of the mass of the ligusticum wallichii to the ethanol is 1g:5-10ml, and the time for reflux extraction is 60-80 min; the weight ratio of the mixed traditional Chinese medicines to water is 1:6-8, the decoction is carried out by boiling with strong fire and then decocting with slow fire, and the decoction time is 25-40 min.
5. The external traditional Chinese medicine for treating soft tissue injury according to claim 1, wherein in the step (3), the soaking time is 90-120 days.
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